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    Letm2 leucine zipper and EF-hand containing transmembrane protein 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361169, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Letm2provided by RGD
    Official Full Name
    leucine zipper and EF-hand containing transmembrane protein 2provided by RGD
    Primary source
    RGD:1311220
    See related
    EnsemblRapid:ENSRNOG00000026180 AllianceGenome:RGD:1311220
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    LETM2S
    Summary
    Predicted to enable transmembrane transporter activity. Predicted to be involved in mitochondrial calcium ion transmembrane transport and mitochondrion organization. Predicted to be located in mitochondrial inner membrane. Predicted to be active in mitochondrion. Orthologous to human LETM2 (leucine zipper and EF-hand containing transmembrane protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 123.1), Thymus (RPKM 39.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Letm2 in Genome Data Viewer
    Location:
    16q12.4
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (73171768..73192336)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (66464958..66489640)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (71241335..71261841)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482516 Neighboring gene nuclear receptor binding SET domain protein 3 Neighboring gene small nucleolar RNA SNORA70 Neighboring gene small nucleolar RNA SNORA15 Neighboring gene Fibroblast growth factor receptor 1 Neighboring gene uncharacterized LOC120097430

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Characterization of the mitochondrial protein LETM1, which maintains the mitochondrial tubular shapes and interacts with the AAA-ATPase BCS1L. Tamai S, et al. J Cell Sci, 2008 Aug 1. PMID 18628306
    2. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ribosome binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial calcium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrion organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    LETM1 domain-containing protein LETM2, mitochondrial
    Names
    LETM1 and EF-hand domain-containing protein 2
    leucine zipper-, EF-hand motif- containing transmembrane protein 2
    leucine zipper-, EF-hand motif- containing transmembrane protein 2S
    leucine zipper-EF-hand containing transmembrane protein 2

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012158.1 → NP_001012158.1  LETM1 domain-containing protein LETM2, mitochondrial isoform 1 precursor

      See identical proteins and their annotated locations for NP_001012158.1

      Status: VALIDATED

      Source sequence(s)
      BC087079
      UniProtKB/Swiss-Prot
      A7VL16, Q5PQQ5
      UniProtKB/TrEMBL
      A0A8I5ZTW7
      Related
      ENSRNOP00000081903.1, ENSRNOT00000118537.2
      Conserved Domains (1) summary
      pfam07766
      Location:121 → 387
      LETM1; LETM1-like protein

    2. NM_001434417.1 → NP_001421346.1  LETM1 domain-containing protein LETM2, mitochondrial isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/TrEMBL
      A0A8I5ZYR9, A6IW13

    3. NM_001434418.1 → NP_001421347.1  LETM1 domain-containing protein LETM2, mitochondrial isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/TrEMBL
      A6IW13

    4. NM_001434419.1 → NP_001421348.1  LETM1 domain-containing protein LETM2, mitochondrial isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/Swiss-Prot
      A7VL16, Q5PQQ5
      UniProtKB/TrEMBL
      A0A8I5ZTW7

    5. NM_001434420.1 → NP_001421349.1  LETM1 domain-containing protein LETM2, mitochondrial isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/Swiss-Prot
      A7VL16, Q5PQQ5
      UniProtKB/TrEMBL
      A0A8I5ZTW7

    6. NM_001434421.1 → NP_001421350.1  LETM1 domain-containing protein LETM2, mitochondrial isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/TrEMBL
      A6IW13, F1LP77

    7. NM_001434422.1 → NP_001421351.1  LETM1 domain-containing protein LETM2, mitochondrial isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/TrEMBL
      A6IW13, F1LP77

    8. NM_001434423.1 → NP_001421352.1  LETM1 domain-containing protein LETM2, mitochondrial isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/TrEMBL
      A6IW13, F1LP77

    9. NM_001434424.1 → NP_001421353.1  LETM1 domain-containing protein LETM2, mitochondrial isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/TrEMBL
      A6IW13, F1LP77

    10. NM_001434425.1 → NP_001421354.1  LETM1 domain-containing protein LETM2, mitochondrial isoform 5

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/TrEMBL
      A6IW13

    11. NM_001434426.1 → NP_001421355.1  LETM1 domain-containing protein LETM2, mitochondrial isoform 6

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/TrEMBL
      D3ZXQ6

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      73171768..73192336
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063275559.1 → XP_063131629.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X6

      UniProtKB/TrEMBL
      D3ZXQ6

    2. XM_063275560.1 → XP_063131630.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X7

      UniProtKB/TrEMBL
      D3ZXQ6

    3. XM_063275570.1 → XP_063131640.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X10

    4. XM_063275525.1 → XP_063131595.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X1

    5. XM_063275563.1 → XP_063131633.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X8

    6. XM_063275531.1 → XP_063131601.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X2

    7. XM_063275542.1 → XP_063131612.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X3

      Related
      ENSRNOP00000062009.5, ENSRNOT00000066144.6

    8. XM_063275567.1 → XP_063131637.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X9

    9. XM_063275536.1 → XP_063131606.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X3

      UniProtKB/TrEMBL
      A6IW13, F1LP77

    10. XM_063275548.1 → XP_063131618.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X4

      UniProtKB/Swiss-Prot
      A7VL16, Q5PQQ5
      UniProtKB/TrEMBL
      A0A8I5ZTW7

    11. XM_063275544.1 → XP_063131614.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X3

      UniProtKB/TrEMBL
      A6IW13, F1LP77
      Related
      ENSRNOP00000032494.8, ENSRNOT00000030489.8

    12. XM_063275535.1 → XP_063131605.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X3

    13. XM_063275547.1 → XP_063131617.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X4

      UniProtKB/Swiss-Prot
      A7VL16, Q5PQQ5
      UniProtKB/TrEMBL
      A0A8I5ZTW7

    14. XM_063275554.1 → XP_063131624.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X4

      UniProtKB/Swiss-Prot
      A7VL16, Q5PQQ5
      UniProtKB/TrEMBL
      A0A8I5ZTW7

    15. XM_063275538.1 → XP_063131608.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X3

      UniProtKB/TrEMBL
      A6IW13, F1LP77

    16. XM_063275546.1 → XP_063131616.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X4

      UniProtKB/Swiss-Prot
      A7VL16, Q5PQQ5
      UniProtKB/TrEMBL
      A0A8I5ZTW7

    17. XM_063275533.1 → XP_063131603.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X3

      UniProtKB/TrEMBL
      A6IW13, F1LP77

    18. XM_063275520.1 → XP_063131590.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZYR9, A6IW13

    19. XM_063275529.1 → XP_063131599.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZYR9, A6IW13
      Related
      ENSRNOP00000083182.1, ENSRNOT00000109594.2

    20. XM_063275552.1 → XP_063131622.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X4

      UniProtKB/Swiss-Prot
      A7VL16, Q5PQQ5
      UniProtKB/TrEMBL
      A0A8I5ZTW7

    21. XM_063275549.1 → XP_063131619.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X4

      UniProtKB/Swiss-Prot
      A7VL16, Q5PQQ5
      UniProtKB/TrEMBL
      A0A8I5ZTW7

    22. XM_063275543.1 → XP_063131613.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X3

    23. XM_063275537.1 → XP_063131607.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X3

    24. XM_063275526.1 → XP_063131596.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZYR9, A6IW13

    25. XM_063275564.1 → XP_063131634.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X8

      UniProtKB/TrEMBL
      A6IW13

    26. XM_063275558.1 → XP_063131628.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X6

      UniProtKB/TrEMBL
      D3ZXQ6

    27. XM_063275568.1 → XP_063131638.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X9

      UniProtKB/TrEMBL
      D3ZXQ6

    28. XM_063275532.1 → XP_063131602.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X2

      UniProtKB/TrEMBL
      A6IW13
      Related
      ENSRNOP00000095230.2, ENSRNOT00000105535.2

    29. XM_063275556.1 → XP_063131626.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X5

      UniProtKB/TrEMBL
      A0A8I5ZTW7

    30. XM_063275523.1 → XP_063131593.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZYR9, A6IW13

    31. XM_063275566.1 → XP_063131636.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X9

      UniProtKB/TrEMBL
      D3ZXQ6
      Related
      ENSRNOP00000102908.1, ENSRNOT00000167314.1

    32. XM_063275528.1 → XP_063131598.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZYR9, A6IW13

    33. XM_039094661.2 → XP_038950589.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZYR9, A6IW13
      Conserved Domains (1) summary
      pfam07766
      Location:121 → 387
      LETM1; LETM1-like protein

    34. XM_063275555.1 → XP_063131625.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X5

      UniProtKB/TrEMBL
      A0A8I5ZTW7

    35. XM_039094664.2 → XP_038950592.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X3

      UniProtKB/TrEMBL
      A6IW13, F1LP77
      Conserved Domains (1) summary
      pfam07766
      Location:121 → 387
      LETM1; LETM1-like protein

    36. XM_039094665.2 → XP_038950593.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X4

      UniProtKB/Swiss-Prot
      A7VL16, Q5PQQ5
      UniProtKB/TrEMBL
      A0A8I5ZTW7
      Conserved Domains (1) summary
      pfam07766
      Location:121 → 387
      LETM1; LETM1-like protein

    37. XM_063275561.1 → XP_063131631.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X8

      UniProtKB/TrEMBL
      A6IW13

    38. XM_063275557.1 → XP_063131627.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X6

      UniProtKB/TrEMBL
      D3ZXQ6

    39. XM_063275534.1 → XP_063131604.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X3

      UniProtKB/TrEMBL
      A6IW13, F1LP77

    40. XM_063275522.1 → XP_063131592.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZYR9, A6IW13

    41. XM_063275545.1 → XP_063131615.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X4

      UniProtKB/Swiss-Prot
      A7VL16, Q5PQQ5
      UniProtKB/TrEMBL
      A0A8I5ZTW7
      Related
      ENSRNOP00000110306.1, ENSRNOT00000157829.1

    42. XM_063275539.1 → XP_063131609.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X3

      UniProtKB/TrEMBL
      A6IW13, F1LP77

    43. XM_063275524.1 → XP_063131594.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZYR9, A6IW13

    44. XM_063275550.1 → XP_063131620.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X4

    45. XM_063275565.1 → XP_063131635.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X9

      UniProtKB/TrEMBL
      D3ZXQ6

    46. XM_063275527.1 → XP_063131597.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZYR9, A6IW13

    47. XM_063275553.1 → XP_063131623.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X4

    48. XM_039094662.2 → XP_038950590.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X2

      UniProtKB/TrEMBL
      A6IW13
      Conserved Domains (1) summary
      pfam07766
      Location:121 → 387
      LETM1; LETM1-like protein

    49. XM_063275569.1 → XP_063131639.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X10

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5PQQ5.1 GenPept UniProtKB/Swiss-Prot:Q5PQQ5

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