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Conserved domains on  [gi|1958685273|ref|XP_038950592|]
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LETM1 domain-containing protein LETM2, mitochondrial isoform X3 [Rattus norvegicus]

Protein Classification

LETM1 domain-containing protein( domain architecture ID 18340129)

LETM1 domain-containing protein similar to mitochondrial proton/calcium exchanger protein (LETM1) which is a mitochondrial proton/calcium antiporter that mediates proton-dependent calcium efflux from mitochondrion

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LETM1_RBD pfam07766
LETM1-like, RBD; Members of this entry are inner mitochondrial membrane proteins which play a ...
 172-392 2.01e-94

LETM1-like, RBD; Members of this entry are inner mitochondrial membrane proteins which play a role in potassium and hydrogen ion exchange. Deletion of LETM1 is thought to be involved in the development of Wolf-Hirschhorn syndrome in humans. This entry represents the ribosome-binding domain (RBD) of LETM1/MDM38 proteins.


:

Pssm-ID: 462258 [Multi-domain]  Cd Length: 229  Bit Score: 285.15  E-value: 2.01e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958685273 172 ADVFRLVPFVVFIIVPFMEFLIPVFLKLFPDMLPSTFESESKKEEKQKKMMGAKLEIAKFLQETMTEMAKrnraklDDDS 251
Cdd:pfam07766  14 RDLFRLVPFSVFIIVPFAELLLPVLLKLFPNLLPSTFWSKKQKEEKLKKRLKARLEVAKFLQETVEESLS------DETT 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958685273 252 SDSSQLSSYVKQVQTG-HKPSTKEIVRFSKLFEDQLALEHLRRPQLVALCKLLELQAFGTNNLLRFQLLMTLRSIKADDE 330
Cdd:pfam07766  88 ELKEEFKEFFKKVRSGgEPPSNEEILKVAKLFKDDLTLDNLSRPQLVALCKYMNLTPFGTDNLLRYRLRHKLLEIKRDDR 167

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958685273 331 VIAKEGVKALSVSELQAACRARGMRSLGLTEEQLRQQLTEWLDLHLKENVPPSLLLLSRTFY 392
Cdd:pfam07766 168 AIAREGVDSLSLEELQSACYSRGIRPLGLSEERLREWLQQWLDLSLNLKVPSSLLLLSRAVL 229
LETM2_N pfam19324
LETM1 domain-containing protein LETM2 N-terminus; This family represents the N-terminal region ...
 1-109 1.30e-62

LETM1 domain-containing protein LETM2 N-terminus; This family represents the N-terminal region of the LETM1-domain- containing protein LETM2, a mitochondrial protein that is expressed preferentially in spermatocytes and spermatozoa during developmental stages from spermatocyte to spermatozoon. LETM2 might contribute to the reorganization of the inner and cristae membranes during spermatogenesis. Despite its name, it does not contain an EF-hand domain as LETM1, but it contains a putative leucine zipper coiled coil domain.


:

Pssm-ID: 466042  Cd Length: 111  Bit Score: 199.25  E-value: 1.30e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958685273   1 MAFYSYNSFLAIFWTRLPGHSVHPPC-SHFPPLAFFHLPDSHLRTAYMKNCGSRKYSYPGLTGNNKVHpLRTRLPQKLHT 79
Cdd:pfam19324   1 MAFYSYNSVLAIARTRFPSHFVHPTCsSYSPSLAFLHLPDSHLNKTYMKNYGSKKYSYPSQSGNKVLH-LRTRLIQKLHT 79

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1958685273  80 -TCWLQNHPGKPQPEQIPEEPKATDPQPTKD 109
Cdd:pfam19324  80 sTCWLQEVPGKPQLEQTTEKPQVTSPQPTKE 110
 
Name Accession Description Interval E-value
LETM1_RBD pfam07766
LETM1-like, RBD; Members of this entry are inner mitochondrial membrane proteins which play a ...
 172-392 2.01e-94

LETM1-like, RBD; Members of this entry are inner mitochondrial membrane proteins which play a role in potassium and hydrogen ion exchange. Deletion of LETM1 is thought to be involved in the development of Wolf-Hirschhorn syndrome in humans. This entry represents the ribosome-binding domain (RBD) of LETM1/MDM38 proteins.


Pssm-ID: 462258 [Multi-domain]  Cd Length: 229  Bit Score: 285.15  E-value: 2.01e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958685273 172 ADVFRLVPFVVFIIVPFMEFLIPVFLKLFPDMLPSTFESESKKEEKQKKMMGAKLEIAKFLQETMTEMAKrnraklDDDS 251
Cdd:pfam07766  14 RDLFRLVPFSVFIIVPFAELLLPVLLKLFPNLLPSTFWSKKQKEEKLKKRLKARLEVAKFLQETVEESLS------DETT 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958685273 252 SDSSQLSSYVKQVQTG-HKPSTKEIVRFSKLFEDQLALEHLRRPQLVALCKLLELQAFGTNNLLRFQLLMTLRSIKADDE 330
Cdd:pfam07766  88 ELKEEFKEFFKKVRSGgEPPSNEEILKVAKLFKDDLTLDNLSRPQLVALCKYMNLTPFGTDNLLRYRLRHKLLEIKRDDR 167

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958685273 331 VIAKEGVKALSVSELQAACRARGMRSLGLTEEQLRQQLTEWLDLHLKENVPPSLLLLSRTFY 392
Cdd:pfam07766 168 AIAREGVDSLSLEELQSACYSRGIRPLGLSEERLREWLQQWLDLSLNLKVPSSLLLLSRAVL 229
LETM2_N pfam19324
LETM1 domain-containing protein LETM2 N-terminus; This family represents the N-terminal region ...
 1-109 1.30e-62

LETM1 domain-containing protein LETM2 N-terminus; This family represents the N-terminal region of the LETM1-domain- containing protein LETM2, a mitochondrial protein that is expressed preferentially in spermatocytes and spermatozoa during developmental stages from spermatocyte to spermatozoon. LETM2 might contribute to the reorganization of the inner and cristae membranes during spermatogenesis. Despite its name, it does not contain an EF-hand domain as LETM1, but it contains a putative leucine zipper coiled coil domain.


Pssm-ID: 466042  Cd Length: 111  Bit Score: 199.25  E-value: 1.30e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958685273   1 MAFYSYNSFLAIFWTRLPGHSVHPPC-SHFPPLAFFHLPDSHLRTAYMKNCGSRKYSYPGLTGNNKVHpLRTRLPQKLHT 79
Cdd:pfam19324   1 MAFYSYNSVLAIARTRFPSHFVHPTCsSYSPSLAFLHLPDSHLNKTYMKNYGSKKYSYPSQSGNKVLH-LRTRLIQKLHT 79

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1958685273  80 -TCWLQNHPGKPQPEQIPEEPKATDPQPTKD 109
Cdd:pfam19324  80 sTCWLQEVPGKPQLEQTTEKPQVTSPQPTKE 110
 
Name Accession Description Interval E-value
LETM1_RBD pfam07766
LETM1-like, RBD; Members of this entry are inner mitochondrial membrane proteins which play a ...
 172-392 2.01e-94

LETM1-like, RBD; Members of this entry are inner mitochondrial membrane proteins which play a role in potassium and hydrogen ion exchange. Deletion of LETM1 is thought to be involved in the development of Wolf-Hirschhorn syndrome in humans. This entry represents the ribosome-binding domain (RBD) of LETM1/MDM38 proteins.


Pssm-ID: 462258 [Multi-domain]  Cd Length: 229  Bit Score: 285.15  E-value: 2.01e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958685273 172 ADVFRLVPFVVFIIVPFMEFLIPVFLKLFPDMLPSTFESESKKEEKQKKMMGAKLEIAKFLQETMTEMAKrnraklDDDS 251
Cdd:pfam07766  14 RDLFRLVPFSVFIIVPFAELLLPVLLKLFPNLLPSTFWSKKQKEEKLKKRLKARLEVAKFLQETVEESLS------DETT 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958685273 252 SDSSQLSSYVKQVQTG-HKPSTKEIVRFSKLFEDQLALEHLRRPQLVALCKLLELQAFGTNNLLRFQLLMTLRSIKADDE 330
Cdd:pfam07766  88 ELKEEFKEFFKKVRSGgEPPSNEEILKVAKLFKDDLTLDNLSRPQLVALCKYMNLTPFGTDNLLRYRLRHKLLEIKRDDR 167

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958685273 331 VIAKEGVKALSVSELQAACRARGMRSLGLTEEQLRQQLTEWLDLHLKENVPPSLLLLSRTFY 392
Cdd:pfam07766 168 AIAREGVDSLSLEELQSACYSRGIRPLGLSEERLREWLQQWLDLSLNLKVPSSLLLLSRAVL 229
LETM2_N pfam19324
LETM1 domain-containing protein LETM2 N-terminus; This family represents the N-terminal region ...
 1-109 1.30e-62

LETM1 domain-containing protein LETM2 N-terminus; This family represents the N-terminal region of the LETM1-domain- containing protein LETM2, a mitochondrial protein that is expressed preferentially in spermatocytes and spermatozoa during developmental stages from spermatocyte to spermatozoon. LETM2 might contribute to the reorganization of the inner and cristae membranes during spermatogenesis. Despite its name, it does not contain an EF-hand domain as LETM1, but it contains a putative leucine zipper coiled coil domain.


Pssm-ID: 466042  Cd Length: 111  Bit Score: 199.25  E-value: 1.30e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958685273   1 MAFYSYNSFLAIFWTRLPGHSVHPPC-SHFPPLAFFHLPDSHLRTAYMKNCGSRKYSYPGLTGNNKVHpLRTRLPQKLHT 79
Cdd:pfam19324   1 MAFYSYNSVLAIARTRFPSHFVHPTCsSYSPSLAFLHLPDSHLNKTYMKNYGSKKYSYPSQSGNKVLH-LRTRLIQKLHT 79

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1958685273  80 -TCWLQNHPGKPQPEQIPEEPKATDPQPTKD 109
Cdd:pfam19324  80 sTCWLQEVPGKPQLEQTTEKPQVTSPQPTKE 110
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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