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    Slc25a22 solute carrier family 25 member 22 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 309111, updated on 9-Dec-2024

    Summary

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    Symbol
    Slc25a22provided by RGD
    Full Name
    solute carrier family 25 member 22provided by RGD
    Primary source
    RGD:1307826
    See related
    EnsemblRapid:ENSRNOG00000049944 AllianceGenome:RGD:1307826
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    GC1; GC-1; RGD1307826
    Summary
    Enables L-glutamate transmembrane transporter activity. Involved in L-glutamate transmembrane transport and regulation of insulin secretion. Located in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 3. Orthologous to human SLC25A22 (solute carrier family 25 member 22). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 127.0), Brain (RPKM 113.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Slc25a22 in Genome Data Viewer
    Location:
    1q41
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (205954713..205966188, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (196528471..196536398, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (214410388..214418236, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene transaldolase 1 Neighboring gene glutamine amidotransferase class 1 domain containing 1 Neighboring gene cell cycle exit and neuronal differentiation 1 Neighboring gene p53-induced death domain protein 1 Neighboring gene small nucleolar RNA, H/ACA box 52 Neighboring gene ribosomal protein lateral stalk subunit P2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mitochondrial glutamate carrier GC1 as a newly identified player in the control of glucose-stimulated insulin secretion. Casimir M, et al. J Biol Chem, 2009 Sep 11. PMID 19584051, Free PMC Article
    2. Identification of the mitochondrial glutamate transporter. Bacterial expression, reconstitution, functional characterization, and tissue distribution of two human isoforms. Fiermonte G, et al. J Biol Chem, 2002 May 31. PMID 11897791
    3. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853
    4. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article
    5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. insulin-secreting cells depend on GC1 for maximal glucose response.
      Title: Mitochondrial glutamate carrier GC1 as a newly identified player in the control of glucose-stimulated insulin secretion.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC109527

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables L-aspartate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables L-glutamate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables L-glutamate transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables L-glutamate transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables amino acid:proton symporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-glutamate transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in L-glutamate transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in L-glutamate transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in aspartate transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in malate-aspartate shuttle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of insulin secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mitochondrial glutamate carrier 1
    Names
    glutamate/H(+) symporter 1
    mitochondrial glutamate carrier 1-like
    solute carrier family 25 (mitochondrial carrier, glutamate), member 22

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014027.1 → NP_001014049.1  mitochondrial glutamate carrier 1

      See identical proteins and their annotated locations for NP_001014049.1

      Status: PROVISIONAL

      Source sequence(s)
      BC090010
      UniProtKB/TrEMBL
      Q5FVG4
      Related
      ENSRNOP00000051753.2, ENSRNOT00000054869.6
      Conserved Domains (1) summary
      pfam00153
      Location:4 → 98
      Mito_carr; Mitochondrial carrier protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      205954713..205966188 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063263993.1 → XP_063120063.1  mitochondrial glutamate carrier 1 isoform X1

    2. XM_063264006.1 → XP_063120076.1  mitochondrial glutamate carrier 1 isoform X1

    3. XM_063264072.1 → XP_063120142.1  mitochondrial glutamate carrier 1 isoform X3

    4. XM_063263977.1 → XP_063120047.1  mitochondrial glutamate carrier 1 isoform X1

    5. XM_063264011.1 → XP_063120081.1  mitochondrial glutamate carrier 1 isoform X1

    6. XM_063264023.1 → XP_063120093.1  mitochondrial glutamate carrier 1 isoform X1

    7. XM_063264021.1 → XP_063120091.1  mitochondrial glutamate carrier 1 isoform X1

    8. XM_063263984.1 → XP_063120054.1  mitochondrial glutamate carrier 1 isoform X1

    9. XM_063264002.1 → XP_063120072.1  mitochondrial glutamate carrier 1 isoform X1

    10. XM_063264015.1 → XP_063120085.1  mitochondrial glutamate carrier 1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JTG5

    11. XM_063263968.1 → XP_063120038.1  mitochondrial glutamate carrier 1 isoform X1

    12. XM_063264057.1 → XP_063120127.1  mitochondrial glutamate carrier 1 isoform X2

      UniProtKB/Swiss-Prot
      A0A0G2K5L2, D3ZRF5, Q5FVG4
      UniProtKB/TrEMBL
      A0A0G2JTG5

    13. XM_039079016.2 → XP_038934944.1  mitochondrial glutamate carrier 1 isoform X2

      UniProtKB/Swiss-Prot
      A0A0G2K5L2, D3ZRF5, Q5FVG4
      UniProtKB/TrEMBL
      A0A0G2JTG5
      Conserved Domains (2) summary
      PTZ00169
      Location:3 → 289
      PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
      pfam00153
      Location:4 → 98
      Mito_carr; Mitochondrial carrier protein

    14. XM_039078995.2 → XP_038934923.1  mitochondrial glutamate carrier 1 isoform X2

      UniProtKB/Swiss-Prot
      A0A0G2K5L2, D3ZRF5, Q5FVG4
      UniProtKB/TrEMBL
      A0A0G2JTG5
      Related
      ENSRNOP00000073467.1, ENSRNOT00000086238.3
      Conserved Domains (2) summary
      PTZ00169
      Location:3 → 289
      PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
      pfam00153
      Location:4 → 98
      Mito_carr; Mitochondrial carrier protein

    15. XM_039079022.2 → XP_038934950.1  mitochondrial glutamate carrier 1 isoform X4

      UniProtKB/TrEMBL
      A0A0G2JTG5
      Conserved Domains (1) summary
      pfam00153
      Location:57 → 166
      Mito_carr; Mitochondrial carrier protein

    16. XM_063264049.1 → XP_063120119.1  mitochondrial glutamate carrier 1 isoform X2

      UniProtKB/Swiss-Prot
      A0A0G2K5L2, D3ZRF5, Q5FVG4
      UniProtKB/TrEMBL
      A0A0G2JTG5

    17. XM_063264046.1 → XP_063120116.1  mitochondrial glutamate carrier 1 isoform X2

      UniProtKB/Swiss-Prot
      A0A0G2K5L2, D3ZRF5, Q5FVG4
      UniProtKB/TrEMBL
      A0A0G2JTG5

    18. XM_063264024.1 → XP_063120094.1  mitochondrial glutamate carrier 1 isoform X2

      UniProtKB/Swiss-Prot
      A0A0G2K5L2, D3ZRF5, Q5FVG4
      UniProtKB/TrEMBL
      A0A0G2JTG5

    19. XM_063264029.1 → XP_063120099.1  mitochondrial glutamate carrier 1 isoform X2

      UniProtKB/Swiss-Prot
      A0A0G2K5L2, D3ZRF5, Q5FVG4
      UniProtKB/TrEMBL
      A0A0G2JTG5

    20. XM_039079019.2 → XP_038934947.1  mitochondrial glutamate carrier 1 isoform X2

      UniProtKB/Swiss-Prot
      A0A0G2K5L2, D3ZRF5, Q5FVG4
      UniProtKB/TrEMBL
      A0A0G2JTG5
      Conserved Domains (2) summary
      PTZ00169
      Location:3 → 289
      PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
      pfam00153
      Location:4 → 98
      Mito_carr; Mitochondrial carrier protein

    21. XM_017589233.3 → XP_017444722.1  mitochondrial glutamate carrier 1 isoform X2

      UniProtKB/Swiss-Prot
      A0A0G2K5L2, D3ZRF5, Q5FVG4
      UniProtKB/TrEMBL
      A0A0G2JTG5
      Conserved Domains (2) summary
      PTZ00169
      Location:3 → 289
      PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
      pfam00153
      Location:4 → 98
      Mito_carr; Mitochondrial carrier protein

    22. XM_063264077.1 → XP_063120147.1  mitochondrial glutamate carrier 1 isoform X4

      UniProtKB/TrEMBL
      A0A0G2JTG5

    23. XM_063264078.1 → XP_063120148.1  mitochondrial glutamate carrier 1 isoform X4

      UniProtKB/TrEMBL
      A0A0G2JTG5

    24. XM_039079009.2 → XP_038934937.1  mitochondrial glutamate carrier 1 isoform X2

      UniProtKB/Swiss-Prot
      A0A0G2K5L2, D3ZRF5, Q5FVG4
      UniProtKB/TrEMBL
      A0A0G2JTG5
      Conserved Domains (2) summary
      PTZ00169
      Location:3 → 289
      PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
      pfam00153
      Location:4 → 98
      Mito_carr; Mitochondrial carrier protein

    25. XM_063264056.1 → XP_063120126.1  mitochondrial glutamate carrier 1 isoform X2

      UniProtKB/Swiss-Prot
      A0A0G2K5L2, D3ZRF5, Q5FVG4
      UniProtKB/TrEMBL
      A0A0G2JTG5

    26. XM_039079004.2 → XP_038934932.1  mitochondrial glutamate carrier 1 isoform X2

      UniProtKB/Swiss-Prot
      A0A0G2K5L2, D3ZRF5, Q5FVG4
      UniProtKB/TrEMBL
      A0A0G2JTG5
      Conserved Domains (2) summary
      PTZ00169
      Location:3 → 289
      PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
      pfam00153
      Location:4 → 98
      Mito_carr; Mitochondrial carrier protein

    27. XM_063264081.1 → XP_063120151.1  mitochondrial glutamate carrier 1 isoform X6

      UniProtKB/TrEMBL
      A6HXX1

    28. XM_063264080.1 → XP_063120150.1  mitochondrial glutamate carrier 1 isoform X6

      UniProtKB/TrEMBL
      A6HXX1

    29. XM_063264079.1 → XP_063120149.1  mitochondrial glutamate carrier 1 isoform X5

    30. XM_063264082.1 → XP_063120152.1  mitochondrial glutamate carrier 1 isoform X7

      UniProtKB/TrEMBL
      A6HXX5
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0G2K5L2.1 GenPept UniProtKB/Swiss-Prot:A0A0G2K5L2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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