Gzf1 GDNF-inducible zinc finger protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gzf1provided by MGI
Official Full Name: GDNF-inducible zinc finger protein 1provided by MGI
Primary source: MGI:MGI:1921783
See related: Ensembl:ENSMUSG00000027439 AllianceGenome:MGI:1921783
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mGZF1; Zfp336; 8430437G08Rik
Summary: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within branching involved in ureteric bud morphogenesis and negative regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including central nervous system; genitourinary system; liver; spleen; and visual system. Orthologous to human GZF1 (GDNF inducible zinc finger protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 7.1), placenta adult (RPKM 6.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 G3; 2 73.53 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (148521305..148534869)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (148679384..148692949)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Progesterone receptors and glucocorticoid receptors, but not estrogen receptors, up-regulate transcription from the GDNF-inducible zinc finger protein promoter
Title: Activation of the GDNF-inducible transcription factor (GIF) gene promoter by glucocorticoid and progesterone.
induction of GZF1 expression via the is required for renal branching morphogenesis
Title: Identification of a novel glial cell line-derived neurotrophic factor-inducible gene required for renal branching morphogenesis.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Gene trapped (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D2Mit405 (e-PCR), detects polymorphism
- UniSTS:129311

NoName (e-PCR)
- UniSTS:234549

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific DNA binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within branching involved in ureteric bud morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: GDNF-inducible zinc finger protein 1

Names: zinc finger protein 336

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001355689.2 → NP_001342618.1 GDNF-inducible zinc finger protein 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.

Source sequence(s)

AL928638

Consensus CDS

CCDS16841.1

UniProtKB/Swiss-Prot

Q4VBD9, Q8BGY0

UniProtKB/TrEMBL

Q9CX96

Conserved Domains (5) summary

COG5048
Location:410 → 538

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:519 → 539

ZF_C2H2; C2H2 Zn finger [structural motif]

sd00019
Location:317 → 337

ZF_C2H2; C2H2 Zn finger [structural motif]

cd18211
Location:6 → 133

BTB_POZ_ZBTB23_GZF1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in glial cell line-derived neurotrophic factor-inducible zinc finger protein 1 (GZF1)

pfam13465
Location:531 → 556

zf-H2C2_2; Zinc-finger double domain
NM_028986.4 → NP_083262.1 GDNF-inducible zinc finger protein 1

See identical proteins and their annotated locations for NP_083262.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.

Source sequence(s)

AL928638

Consensus CDS

CCDS16841.1

UniProtKB/Swiss-Prot

Q4VBD9, Q8BGY0

UniProtKB/TrEMBL

Q9CX96

Related

ENSMUSP00000028928.8, ENSMUST00000028928.8

Conserved Domains (5) summary

COG5048
Location:410 → 538

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:519 → 539

ZF_C2H2; C2H2 Zn finger [structural motif]

sd00019
Location:317 → 337

ZF_C2H2; C2H2 Zn finger [structural motif]

cd18211
Location:6 → 133

BTB_POZ_ZBTB23_GZF1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in glial cell line-derived neurotrophic factor-inducible zinc finger protein 1 (GZF1)

pfam13465
Location:531 → 556

zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

148521305..148534869

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036162645.1 → XP_036018538.1 GDNF-inducible zinc finger protein 1 isoform X1

UniProtKB/Swiss-Prot

Q4VBD9, Q8BGY0

UniProtKB/TrEMBL

Q9CX96

Conserved Domains (5) summary

COG5048
Location:410 → 538

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:519 → 539

ZF_C2H2; C2H2 Zn finger [structural motif]

sd00019
Location:317 → 337

ZF_C2H2; C2H2 Zn finger [structural motif]

cd18211
Location:6 → 133

BTB_POZ_ZBTB23_GZF1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in glial cell line-derived neurotrophic factor-inducible zinc finger protein 1 (GZF1)

pfam13465
Location:531 → 556

zf-H2C2_2; Zinc-finger double domain
XM_006500305.5 → XP_006500368.1 GDNF-inducible zinc finger protein 1 isoform X1

See identical proteins and their annotated locations for XP_006500368.1

UniProtKB/Swiss-Prot

Q4VBD9, Q8BGY0

UniProtKB/TrEMBL

Q9CX96

Conserved Domains (5) summary

COG5048
Location:410 → 538

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:519 → 539

ZF_C2H2; C2H2 Zn finger [structural motif]

sd00019
Location:317 → 337

ZF_C2H2; C2H2 Zn finger [structural motif]

cd18211
Location:6 → 133

BTB_POZ_ZBTB23_GZF1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in glial cell line-derived neurotrophic factor-inducible zinc finger protein 1 (GZF1)

pfam13465
Location:531 → 556

zf-H2C2_2; Zinc-finger double domain