BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in glial cell line-derived neurotrophic factor-inducible zinc finger protein 1 (GZF1); GZF1 is also called GDNF-inducible zinc finger protein 1, zinc finger and BTB domain-containing protein 23 (ZBTB23), or zinc finger protein 336 (ZNF336). It is a sequence-specific transcriptional repressor that binds the GZF1 responsive element (GRE), with the consensus sequence of 5'-TGCGCN[TG][CA]TATA-3'. It may play a role in renal branching morphogenesis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37674207   6 VLLESKSSPLNLLHEMHELRLLGHLCDVTVSIENQGVHEDFMAHKAVLAATSKFFKEVFLNEKSADGTRTNVYLNEVQAV 85
Cdd:cd18211   1 VLLESKSAPSNLLNEMHKLRLLGHLCDVTVQVEHQGSKEEFSAHKAVLAASSKYFKEVFLNEKISDGKNTNVMLNEIYTA 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 37674207  86 DFASFLEFVYTAKVRVEEDRVQQMLEVAEKLKCLDLSETCLQLKKQML 133
Cdd:cd18211  81 DFASFLEFVYTAKVEVEEDRVQRMLEIAEKLKCLDLSETCFQLKKQML 128

Zinc-finger double domain;

                          10        20
                  ....*....|....*....|....*.
gi 37674207   531 SLYQHIKVHTGERPYCCDQCGKQFTQ 556
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26

FOG: Zn-finger [General function prediction only];

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37674207 514 SKPFKCEVCLRTFAqRNSLYQHIK---VHTGE--RPYCCD--QCGKQFTQVNALQRHHRIHTGEKPYMCNA--CGRTFTD 584
Cdd:COG5048 287 SLPIKSKQCNISFS-RSSPLTRHLrsvNHSGEslKPFSCPysLCGKLFSRNDALKRHILLHTSISPAKEKLlnSSSKFSP 365

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 37674207 585 KSTLRRHTSIHDKNTpwksflvIVDGSPKNDEGHKTEQPDDEYASPKLSDRLLSFGENSHFNNLLEVQGNVP 656
Cdd:COG5048 366 LLNNEPPQSLQQYKD-------LKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNR 430

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in glial cell line-derived neurotrophic factor-inducible zinc finger protein 1 (GZF1); GZF1 is also called GDNF-inducible zinc finger protein 1, zinc finger and BTB domain-containing protein 23 (ZBTB23), or zinc finger protein 336 (ZNF336). It is a sequence-specific transcriptional repressor that binds the GZF1 responsive element (GRE), with the consensus sequence of 5'-TGCGCN[TG][CA]TATA-3'. It may play a role in renal branching morphogenesis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37674207   6 VLLESKSSPLNLLHEMHELRLLGHLCDVTVSIENQGVHEDFMAHKAVLAATSKFFKEVFLNEKSADGTRTNVYLNEVQAV 85
Cdd:cd18211   1 VLLESKSAPSNLLNEMHKLRLLGHLCDVTVQVEHQGSKEEFSAHKAVLAASSKYFKEVFLNEKISDGKNTNVMLNEIYTA 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 37674207  86 DFASFLEFVYTAKVRVEEDRVQQMLEVAEKLKCLDLSETCLQLKKQML 133
Cdd:cd18211  81 DFASFLEFVYTAKVEVEEDRVQRMLEIAEKLKCLDLSETCFQLKKQML 128

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37674207     32 DVTVSIENQgvheDFMAHKAVLAATSKFFKEVFLNEKSADGTrTNVYLNEVQAVDFASFLEFVYTAKVRVEEDRVQQMLE 111
Cdd:smart00225   1 DVTLVVGGK----KFHAHKAVLAAHSPYFKALFSSDFKESDK-SEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLE 75

                           90
                   ....*....|....
gi 37674207    112 VAEKLKCLDLSETC 125
Cdd:smart00225  76 LADYLQIPGLVELC 89

Zinc-finger double domain;

                          10        20
                  ....*....|....*....|....*.
gi 37674207   447 ALKTHLRVHTGERPFVCDECGARFTQ 472
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26

Zinc-finger double domain;

                          10        20
                  ....*....|....*....|....*
gi 37674207   559 ALQRHHRIHTGEKPYMCNACGRTFT 583
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25

hypothetical protein; Provisional

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37674207   30 LCDVTVSIenqGVHEDFMAHKAVLAATSKFFKEVFLNEKSADG--TRTNVYLNEVQAVDfaSFLEFVYtakvrveeDRVQ 107
Cdd:PHA02713  25 LCDVIITI---GDGEEIKAHKTILAAGSKYFRTLFTTPMIIRDlvTRVNLQMFDKDAVK--NIVQYLY--------NRHI 91

                         90
                 ....*....|...
gi 37674207  108 QMLEVAEKLKCLD 120
Cdd:PHA02713  92 SSMNVIDVLKCAD 104

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.

                          10        20
                  ....*....|....*....|...
gi 37674207   573 YMCNACGRTFTDKSTLRRHTSIH 595
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in glial cell line-derived neurotrophic factor-inducible zinc finger protein 1 (GZF1); GZF1 is also called GDNF-inducible zinc finger protein 1, zinc finger and BTB domain-containing protein 23 (ZBTB23), or zinc finger protein 336 (ZNF336). It is a sequence-specific transcriptional repressor that binds the GZF1 responsive element (GRE), with the consensus sequence of 5'-TGCGCN[TG][CA]TATA-3'. It may play a role in renal branching morphogenesis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37674207   6 VLLESKSSPLNLLHEMHELRLLGHLCDVTVSIENQGVHEDFMAHKAVLAATSKFFKEVFLNEKSADGTRTNVYLNEVQAV 85
Cdd:cd18211   1 VLLESKSAPSNLLNEMHKLRLLGHLCDVTVQVEHQGSKEEFSAHKAVLAASSKYFKEVFLNEKISDGKNTNVMLNEIYTA 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 37674207  86 DFASFLEFVYTAKVRVEEDRVQQMLEVAEKLKCLDLSETCLQLKKQML 133
Cdd:cd18211  81 DFASFLEFVYTAKVEVEEDRVQRMLEIAEKLKCLDLSETCFQLKKQML 128

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37674207  30 LCDVTVSIENqgvhEDFMAHKAVLAATSKFFKEVFLNEKSADGTRTnVYLNEVQAVDFASFLEFVYTAKVRVEEDRVQQM 109
Cdd:cd18186   1 LCDVTLVVGG----REFPAHRAVLAARSPYFRAMFSSGMKESSSSE-IELDDVSPEAFEALLDYIYTGELELSEENVEEL 75

                ....*..
gi 37674207 110 LEVAEKL 116
Cdd:cd18186  76 LAAADKL 82

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 24 (ZBTB24); ZBTB24, also called zinc finger protein 450, functions as a transcription factor essentially involved in B-cell functions in humans. The loss-of-function mutations in ZBTB24 can cause ICF2 (immunodeficiency, centromeric instability and facial anomalies syndrome 2) with immunological characteristics of greatly reduced serum antibodies and circulating memory B cells. ZBTB24 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37674207   8 LESKSSPLNLLHEMHELRLLGHLCDVTVSIENqgVHedFMAHKAVLAATSKFFKEVFLNEKSADGTrtnVYLNEVQAVD- 86
Cdd:cd18212   1 IHSKTHKDTVLTNFEEQRKKDFLCDITLIVEN--VQ--FRAHKALLAASSEYFSMMFADEGEVGQS---IYMLEGMVAEt 73

                        90       100       110
                ....*....|....*....|....*....|....*
gi 37674207  87 FASFLEFVYTAKVRVEEDRVQQMLEVAEKLKCLDL 121
Cdd:cd18212  74 FGALLEFIYTGCLQVGEKSLEQILATAQFLKVNDL 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37674207  17 LLHEMHELRLLGHLCDVTVSIENqgvhEDFMAHKAVLAATSKFFKEVF-LNEKSADGTRTNVYLNEVQAVDFASFLEFVY 95
Cdd:cd18245   1 LLRALNSFREEPHLCDATLVVGG----EEIPVQKNVLAAASPYFRAKLnYNPPKDDGSTYKIELEGISVEVMEEILDYIY 76

                        90       100       110
                ....*....|....*....|....*....|..
gi 37674207  96 TAKVRVEEDRVQQMLEVAEKLKCLDLSETCLQ 127
Cdd:cd18245  77 TGQIKLSEDNIQDIVQAADLLLMTDLKDLCCE 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44); ZBTB44, also called BTB/POZ domain-containing protein 15 (BTBD15) or zinc finger protein 851 (ZNF851), may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB44 showed a suggestive association with disease progression of Crohn's disease. ZBTB44 has also preferentially been recognized by sera of patients with peripheral T-cell lymphoma (PTCL). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37674207  17 LLHEMHELRLLGHLCDVTVSIENQgvheDFMAHKAVLAATSKFFKEVFLNEKS------ADGTRTNVYLNEVQAVDFASF 90
Cdd:cd18228   6 LLGKLNSLRNEGHFCDVTIRVQDK----IFRAHKVVLAACSDFFRSKLVGQASprlvlvSPAGKCVLDLHHVTVTGFAPL 81

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 37674207  91 LEFVYTAKVRVEEDRVQQMLEVAEKLKCLDLSETCLQLKKQMLE 134
Cdd:cd18228  82 LEYAYTSTLSINTENIIDVLAAASYMQMFNVANTCSEFMKSSIL 125

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37674207  14 PLNLLHEMHELRLLGHLCDVTVSIENqgvHEdFMAHKAVLAATSKFFKEVFlnekSADGTRTNVYLNEVQAVDFASF--- 90
Cdd:cd18306   2 PESVLAKLNALRKNRQFCDVILQVGG---HE-IPAHRAVLACASPYLFELF----SSDSDGESILTVKLDGLDPDAVevl 73

                        90       100       110
                ....*....|....*....|....*....|....*
gi 37674207  91 LEFVYTAKVRVEEDRVQQMLEVAEKLKCLDLSETC 125
Cdd:cd18306  74 VNYAYTSRLEVPADLVKSVYSAAKKLKMDRVKKAC 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 39 (ZBTB39); ZBTB39 may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37674207   8 LESKSSPLNLLHEMHELRLLGHLCDVTVSIENQgvheDFMAHKAVLAATSKFFKEVFLNeKSADGTRTNVyLNEVQAVDF 87
Cdd:cd18224   4 LHSSDHPNNLLKELNKCRLSETMCDVTIVVGNR----SFAAHKAVLACAAGYFQKLFLS-TELDVARTYV-VDFITPANF 77

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 37674207  88 ASFLEFVYTAKVRVEEDRVQQMLEVAEKLKCLDLSETC 125
Cdd:cd18224  78 EKVLSFIYTSELFTDLINVGVIYEVAEKLGMEDLLKAC 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7 (ZBTB7); There are three ZBTB7 isoforms: ZBTB7A, ZBTB7B, and ZBTB7C. ZBTB7A is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. ZBTB7B is a transcriptional regulator of extracellular matrix gene expression. ZBTB7C is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. ZBTB7 isoforms contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37674207  17 LLHEMHELRLLGHLCDVTVSIENQgvheDFMAHKAVLAATSKFFKEVFLNEKSADGtrTNVY-LNEVQAVDFASFLEFVY 95
Cdd:cd18198  12 ILSGLNEQRTQGLLCDVVILVQGR----EYRTHRSVLAACSQYFKKLFTSGAVVDQ--QNVYeIDFVSPEALTALLEFAY 85

                        90       100       110
                ....*....|....*....|....*....|...
gi 37674207  96 TAKVRVEEDRVQQMLEVAEKLKCLDLSETCLQL 128
Cdd:cd18198  86 TATLTVSTANVGDILSAARLLEIPCVSHVCAEI 118

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37674207  21 MHELRLLGHLCDVTVSIENQgvheDFMAHKAVLAATSKFFKEVFLNEKSaDGTRTNVYLNEVQAVDFASFLEFVYTAKVR 100
Cdd:cd18338  12 MNELRSQNLLCDVTIVAEDV----EIAAHRVVLAACSPYFHAMFTGEMS-ESRAKRVRIKEVDGWTLKMLIDYVYTAEIQ 86

                        90       100       110
                ....*....|....*....|....*....|...
gi 37674207 101 VEEDRVQQMLEVAEKLKCLDLSETCLQLKKQML 133
Cdd:cd18338  87 VTEENVQVLLPAAGLLQLQDVKKTCCEFLESQL 119

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also called BTB and kelch domain-containing protein 5 (BKLHD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Deletion of KLHL32 may be ssociated with Tourette syndrome and obsessive-compulsive disorder. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37674207   3 SGTVLLESKSSPLNLLHEMHELRLLGHLCDVTVSIENQGVHedfmAHKAVLAATSKFFKEVF---LNEKSADgtrtNVYL 79
Cdd:cd18261   1 TGQRLCQSKSHKDAVLAALNQQRNDGILCDITLVAEEQKFH----AHKAVLAACSDYFRAMFslcMVESEAD----EVNL 72

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 37674207  80 NEVQAVDFASFLEFVYTAKVRVEEDRVQQMLEVAEKLKCLDLSETCLQLKKQMLES 135
Cdd:cd18261  73 HGVTSLGLKQALDFAYTGQILLEPGVIQDVLAAGSHLQLLELLSLCSHYLIQELNS 128

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37674207  21 MHELRLLGHLCDVTVSIENqgvhEDFMAHKAVLAATSKFFKEVFLNEKSAdgTRTN-VYLNEVQAVDFASFLEFVYTAKV 99
Cdd:cd18235  12 MNELRKQNLLCDVILVADG----VEIPAHRVVLASCSPYFHAMFTGDLSE--SRANrVTLQDVDGKALLLLIDYVYTAEI 85

                        90       100       110
                ....*....|....*....|....*....|....
gi 37674207 100 RVEEDRVQQMLEVAEKLKCLDLSETCLQ-LKKQM 132
Cdd:cd18235  86 QVTEENVQVLLPAANLLQLTDVRDACCDfLQSQL 119

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 46 (ZBTB46); ZBTB46 is also called BTB-ZF protein expressed in effector lymphocytes (BZEL), BTB/POZ domain-containing protein 4 (BTBD4), or zinc finger protein 340 (ZNF340). It is a conventional dendritic cell (cDC) lineage specific transcription factor that acts as a negative regulator required to prevent activation of classical dendritic cells in the steady state. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37674207  16 NLLHEMHELRLLGHLCDVTVSIENQgvheDFMAHKAVLAATSKFFKEVFLNEKSADGTRTNVYLNEVQAVDFASFLEFVY 95
Cdd:cd18230   7 HLLRELNEQRQHGILCDVCIIVEGK----IFKAHKNVLLGSSRYFKTLYCQVQKTSDQATVTHLDIVTAQGFKAIIDFMY 82

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 37674207  96 TAKVRVEEDRVQQMLEVAEKLKCLDLSETCLQLKKQMLE 134
Cdd:cd18230  83 SAHLALTSKNVIEVMSAASYLQMTDIVQACHNFIKAALD 121

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also called BTB/POZ domain-containing protein 5 (BTBD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37674207  17 LLHEMHELRLLGHLCDVTVSIENQGVHedfmAHKAVLAATSKFFKEVF---LNEKSADGTrtnvylnEVQAVDFAS---F 90
Cdd:cd18257   5 LLQGLNLLRQHHELCDVVLRVGDVKIH----AHKVVLASCSPYFKAMFtgnLSEKENSEV-------EFQCIDETAlqaI 73

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 37674207  91 LEFVYTAKVRVEEDRVQQMLEVAEKLKC-LDLSETCLQLKKQM 132
Cdd:cd18257  74 VEYAYTGTVFISQATVESLLPAANLLQIkLVLKECCDFLESQL 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 49 (ZBTB49); ZBTB49, also called zinc finger protein 509 (ZNF509), is a transcription factor that inhibits cell proliferation by activating either CDKN1A/p21 transcription or RB1 transcription. There are four ZNF509 isoforms generated by alternative splicing. Short ZNF509 (ZNF509S1, -S2 and -S3) isoforms contain one or two out of the seven zinc-fingers contained in long ZNF509 (ZNF509L). ZBTB49 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37674207  17 LLHEMHELRLLGHLCDVTVSIenQGVHedFMAHKAVLAATSKFFKEVFLNeksADGTRTNVYLNEVQAVD-FASFLEFVY 95
Cdd:cd18233   5 LLQQLHEQRIQGLLCDCMLVV--KGVC--FKAHKNVLAAFSQYFRSLFQN---SSSQKNDVFHLDIKNVGgIGQILDFMY 77

                        90       100       110
                ....*....|....*....|....*....|
gi 37674207  96 TAKVRVEEDRVQQMLEVAEKLKCLDLSETC 125
Cdd:cd18233  78 TSHLDLNQDNVQVMLDIAQCLQVQNVLNMC 107

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 3 (KLHL3); KLHL3 is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37674207  21 MHELRLLGHLCDVTVSIENQGVHedfmAHKAVLAATSKFFKEVFLNEKSADGTRtNVYLNEVQAVDFASFLEFVYTAKVR 100
Cdd:cd18339  12 MNELRSKQLLCDVTIVAEDVEIE----AHRVVLAACSPYFCAMFTGDMSESKAK-KIEIKDVDGQTLSKLIDYIYTAEIE 86

                        90       100       110
                ....*....|....*....|....*....|...
gi 37674207 101 VEEDRVQQMLEVAEKLKCLDLSETCLQLKKQML 133
Cdd:cd18339  87 VTEENVQVLLPAASLLQLMDVRQNCCDFLQSQL 119

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 16 (ZBTB16); ZBTB16 is also called promyelocytic leukemia zinc finger protein, zinc finger protein 145, or zinc finger protein PLZF. It is a DNA-binding transcription factor essential for undifferentiated cell maintenance. ZBTB16 also acts as a downstream transcriptional regulator of Osterix and can be useful as a late marker of osteoblastic differentiation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37674207  14 PLNLLHEMHELRLLGHLCDVTVSIENQgvheDFMAHKAVLAATSKFFkEVFLNEKSADGTrtnvyLNEVQAVDFASFLEF 93
Cdd:cd18205   2 PTGLLHKANQMRLAGTLCDVVIMVDSQ----EFHAHRTVLACTSKMF-EILFHRNSQHYT-----LDFLSPKTFQQILEY 71

                        90       100       110
                ....*....|....*....|....*....|....*
gi 37674207  94 VYTAKVRVEEDRVQQMLEVAEKLKCLDLSETCLQL 128
Cdd:cd18205  72 AYTATLQAKVEDLDDLLYAAEILEIEYLEEQCLKI 106

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 10 (ZBTB10); ZBTB10, also called zinc finger protein RIN ZF, is an mRNA target of miR-27a and a transcriptional repressor of Specificity protein (Sp) expression. The microRNA-27a:ZBTB10-specificity protein pathway is involved in follicle stimulating hormone-induced VEGF, Cox2, and survivin expression in ovarian epithelial cancer cells. ZBTB10 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37674207  17 LLHEMHELRLLGHLCDVTVSIENQgvheDFMAHKAVLAATSKFFKEV--FLNEKSADGTrTNVYLNEVQAVDFASFLEFV 94
Cdd:cd18201   8 LLQELNEQRKKGILCDVNIVVSGK----VFRAHKNILVAGSRFFKTLycFTNKESCDQT-TVTHLDVVAVQGFSVILDFM 82

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 37674207  95 YTAKVRVEEDRVQQMLEVAEKLKCLDLSETCLQLKKQML 133
Cdd:cd18201  83 YSGNLVLTSQNAIEVMSVASYLQMTEVVQSCRNFIKDAL 121

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 4 (ZBTB4); ZBTB4, also called KAISO-like zinc finger protein 1 (KAISO-L1), is a transcriptional repressor with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It can also bind specifically to a single methyl-CpG pair and can bind hemimethylated DNA but with a lower affinity compared to methylated DNA. ZBTB4 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37674207  17 LLHEMHELRLLGHLCDVTVSIENQgvheDFMAHKAVLAATSKFFKEVFLNE------------KSADGTRTNVYLNEVQA 84
Cdd:cd18195   5 LLLQLNEQRLRGLFCDVTLIAGDT----KFRAHRSVLAASSPYFRELLSSPlplgaaavaaapGATQSPERVLELPGVKA 80

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 37674207  85 VDFASFLEFVYTAKVRVEEDR-VQQMLEVAEKL--KCL 119
Cdd:cd18195  81 GVFSDVLNFIYSSRVALPGSAaAKELGAAGKRLgiPFL 118

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37674207  23 ELRLLGHLCDVTVSIENQgvheDFMAHKAVLAATSKFFKEVFLNEKSaDGTRTNVYLNEVQAVDFASFLEFVYTAKVRVE 102
Cdd:cd18240  10 ELRLEGKLCDVVIRVNGV----EFPAHRNILCACSPYFRALFTNGWN-ETEKKVYKIPGVSPEMMELIIEYAYTRTVPIT 84

                        90       100       110
                ....*....|....*....|....*....|.
gi 37674207 103 EDRVQQMLEVAEKLKCLDLSETCLQ-LKKQM 132
Cdd:cd18240  85 AENVEELLPAADQFNIMGIVKACCDfLEDQL 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37674207  21 MHELRLLGHLCDVTVSIENQGVHedfmAHKAVLAATSKFFKEVFLNEKsADGTRTNVYLNEVQAVDFASFLEFVYTAKVR 100
Cdd:cd18238   6 LHQFYENGELCDVTLKVGEKSIH----CHRLVLACVSPYFRAMFTSEM-AESKQDSITIKDIDEEAVELLVDFAYTGKLT 80

                        90       100       110
                ....*....|....*....|....*....|...
gi 37674207 101 VEEDRVQQMLEVAEKLKCLDLSETCLQLKKQML 133
Cdd:cd18238  81 LTVDNVQSLLYAASLLQVEEVAKACCEFMKDHL 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C); ZBTB7C is also called affected by papillomavirus DNA integration in ME180 cells protein 1 (APM-1), zinc finger and BTB domain-containing protein 36 (ZBTB36), zinc finger protein 857C (ZNF857C), or kidney cancer-related POZ domain and Kruppel-like protein (Kr-POK). It is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. It may act as an important regulator of fatty acid synthesis and may induce rapid cancer cell proliferation by increasing palmitate synthesis. The ZBTB7C gene has been identified as a susceptibility gene to ischemic injury. ZBTB7C contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37674207  17 LLHEMHELRLLGHLCDVTVSIENQgvheDFMAHKAVLAATSKFFKEVFLNEKSADgtRTNVY-LNEVQAVDFASFLEFVY 95
Cdd:cd18328  12 VLCSLNEQRHDGLLCDVVLIVQDQ----EYRTHRSVLAACSKYFKKLFTAGTLAD--QPYVYeIDFVTPEALSAILEFAY 85

                        90       100       110
                ....*....|....*....|....*....|...
gi 37674207  96 TAKVRVEEDRVQQMLEVAEKLKCLDLSETCLQL 128
Cdd:cd18328  86 TSTLTITTSNVKHILNAAQMLEIQCIINVCLEI 118