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    AI182371 expressed sequence AI182371 [ Mus musculus (house mouse) ]

    Gene ID: 98870, updated on 27-Nov-2024

    Summary

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    Official Symbol
    AI182371provided by MGI
    Official Full Name
    expressed sequence AI182371provided by MGI
    Primary source
    MGI:MGI:2138853
    See related
    Ensembl:ENSMUSG00000035875 AllianceGenome:MGI:2138853
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Expression
    Biased expression in liver E18 (RPKM 25.4), liver adult (RPKM 24.5) and 2 other tissues See more
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    Genomic context

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    See AI182371 in Genome Data Viewer
    Location:
    2 B; 2 23.34 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (34971870..34991556, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (35081893..35101544, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene hemolytic complement Neighboring gene predicted gene 13449 Neighboring gene STARR-seq mESC enhancer starr_04276 Neighboring gene predicted gene, 39794 Neighboring gene STARR-positive B cell enhancer ABC_E4440 Neighboring gene centriolin Neighboring gene STARR-positive B cell enhancer ABC_E2616 Neighboring gene STARR-positive B cell enhancer ABC_E5906 Neighboring gene RAB14, member RAS oncogene family

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Alpha-macroglobulins: structure, shape, and mechanism of proteinase complex formation. Sottrup-Jensen L. J Biol Chem, 1989 Jul 15. PMID 2473064
    2. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
    5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    hemolytic complement-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001243102.2 → NP_001230031.1  hemolytic complement-like isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, and it contains an alternate 3' exon and thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      AL845534
      UniProtKB/TrEMBL
      Q505K6
      Related
      ENSMUSP00000154570.2, ENSMUST00000226631.2
      Conserved Domains (2) summary
      cd00017
      Location:269 → 337
      ANATO; Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to ...
      pfam01835
      Location:134 → 228
      A2M_N; MG2 domain

    2. NM_001243103.2 → NP_001230032.1  hemolytic complement-like isoform 3 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate 3' exon, and thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (3) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      AL845534
      UniProtKB/TrEMBL
      Q505K6
      Related
      ENSMUSP00000154033.2, ENSMUST00000226972.2
      Conserved Domains (2) summary
      cd00017
      Location:268 → 336
      ANATO; Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to ...
      pfam01835
      Location:133 → 227
      A2M_N; MG2 domain

    3. NM_001379434.1 → NP_001366363.1  hemolytic complement-like isoform 4 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) encodes the longest isoform (4).
      Source sequence(s)
      AL845534
      UniProtKB/TrEMBL
      Q8BWN9
      Conserved Domains (3) summary
      cd00017
      Location:269 → 337
      ANATO; Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to ...
      pfam01835
      Location:134 → 228
      A2M_N; MG2 domain
      pfam17790
      Location:32 → 128
      MG1; Macroglobulin domain MG1

    4. NM_001379435.1 → NP_001366364.1  hemolytic complement-like isoform 5 precursor

      Status: VALIDATED

      Source sequence(s)
      AL845534
      Conserved Domains (1) summary
      pfam17790
      Location:32 → 128
      MG1; Macroglobulin domain MG1

    5. NM_001379436.1 → NP_001366365.1  hemolytic complement-like isoform 6 precursor

      Status: VALIDATED

      Source sequence(s)
      AL845534
      Conserved Domains (1) summary
      pfam17790
      Location:28 → 127
      MG1; Macroglobulin domain MG1

    6. NM_001424716.1 → NP_001411645.1  hemolytic complement-like isoform 7 precursor

      Status: VALIDATED

      Source sequence(s)
      AL845534

    7. NM_001424717.1 → NP_001411646.1  hemolytic complement-like isoform 8 precursor

      Status: VALIDATED

      Source sequence(s)
      AL845534

    8. NM_001424718.1 → NP_001411647.1  hemolytic complement-like isoform 9 precursor

      Status: VALIDATED

      Source sequence(s)
      AL845534

    9. NM_178885.5 → NP_849216.2  hemolytic complement-like isoform 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AL845534
      Consensus CDS
      CCDS15958.2
      UniProtKB/TrEMBL
      A2AS37, Q8BWN9
      Related
      ENSMUSP00000037754.6, ENSMUST00000045776.5
      Conserved Domains (2) summary
      cd00017
      Location:268 → 336
      ANATO; Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to ...
      pfam01835
      Location:133 → 227
      A2M_N; MG2 domain

    RNA

    1. NR_166659.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL845534

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      34971870..34991556 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017319351.3 → XP_017174840.1  hemolytic complement-like isoform X1

      UniProtKB/TrEMBL
      A0A2I3BRQ1
      Conserved Domains (3) summary
      cd00017
      Location:279 → 347
      ANATO; Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to ...
      pfam17790
      Location:42 → 138
      MG1; Macroglobulin domain MG1
      pfam01835
      Location:145 → 238
      A2M_N; MG2 domain
    Nucleotide Protein Strain
    Heading Accession and Version

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