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Conserved domains on  [gi|340745359|ref|NP_001230032|]
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hemolytic complement-like isoform 3 precursor [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MG1 pfam17790
Macroglobulin domain MG1; This entry represents the N-terminal macroglobulin domain found in ...
 28-127 3.13e-20

Macroglobulin domain MG1; This entry represents the N-terminal macroglobulin domain found in complement proteins C3, C4 and C5.


:

Pssm-ID: 465508  Cd Length: 101  Bit Score: 84.32  E-value: 3.13e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340745359   28 EQTYIISTPIVFRVGAPENVTVQAHGHTEAFDTTVSVKSYPDENVRYSFSTVNLSPENKFQNTAILTIQAKQLSEGQNSF 107
Cdd:pfam17790   1 EPLYLLTAPNVLRVESEENIVVEAHGYTAPVEVTITVMDFPDKKALLASTSVTLNSDNNYQALVTIKIPAKLFRKDRKGK 80

                          90       100
                  ....*....|....*....|
gi 340745359  108 SNSYLEVVSKHFAKLEIVPI 127
Cdd:pfam17790  81 QYVYLQAKFPHFELEKVVLV 100
MG2 pfam01835
MG2 domain; This is the MG2 (macroglobulin) domain of alpha-2-macroglobulin in eukaryotes. ...
 133-227 7.73e-19

MG2 domain; This is the MG2 (macroglobulin) domain of alpha-2-macroglobulin in eukaryotes. Alpha-2-macroglobulins (A2Ms) are plasma proteins that trap and inhibit a broad range of proteases and are major components of the eukaryotic innate immune system. However, A2M-like proteins were identified in pathogenically invasive bacteria and species that colonize higher eukaryotes. This domain is found in eukaryotic and bacterial proteins. In human A2Ms, this domain is termed macroglobulin-like (MG) domain 2 and in Salmonella enterica ser A2Ms, this is domain 4.


:

Pssm-ID: 426464 [Multi-domain]  Cd Length: 95  Bit Score: 80.05  E-value: 7.73e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340745359  133 SLFVQTDKSVYTPQQPVKVRVYSVNDDLEPATR-ETVLTFIDPEGSQVDTIEG-NNLTGIASFpDFEIPSNPKHGRWTVK 210
Cdd:pfam01835   1 RAFVYTDRGIYRPGETVHFKGLLRDQDLRPLAGlPVTLTVTDPDGNEVRRLPLtTDEFGGFSG-SFPLPETAPTGTYTVV 79

                          90
                  ....*....|....*..
gi 340745359  211 AkYREDASKTGTTYFEV 227
Cdd:pfam01835  80 L-RDGAGGSLGSGSFRV 95
ANATO cd00017
Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments ...
 268-336 4.07e-18

Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to repeats in fibulins.


:

Pssm-ID: 237984  Cd Length: 70  Bit Score: 77.50  E-value: 4.07e-18
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340745359 268 KINEQASTYKHPMIKKCCYDGARYNI-HETCVQRAARVKIGPICVKAFTLCCNMAHQILENSTFKHIHLS 336
Cdd:cd00017    1 KNSEKAAQYKDKELRKCCLDGMRENPmGQTCEERAAYITDGKECRKAFLECCVYAEELRDEEREDGLGLA 70
 
Name Accession Description Interval E-value
MG1 pfam17790
Macroglobulin domain MG1; This entry represents the N-terminal macroglobulin domain found in ...
 28-127 3.13e-20

Macroglobulin domain MG1; This entry represents the N-terminal macroglobulin domain found in complement proteins C3, C4 and C5.


Pssm-ID: 465508  Cd Length: 101  Bit Score: 84.32  E-value: 3.13e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340745359   28 EQTYIISTPIVFRVGAPENVTVQAHGHTEAFDTTVSVKSYPDENVRYSFSTVNLSPENKFQNTAILTIQAKQLSEGQNSF 107
Cdd:pfam17790   1 EPLYLLTAPNVLRVESEENIVVEAHGYTAPVEVTITVMDFPDKKALLASTSVTLNSDNNYQALVTIKIPAKLFRKDRKGK 80

                          90       100
                  ....*....|....*....|
gi 340745359  108 SNSYLEVVSKHFAKLEIVPI 127
Cdd:pfam17790  81 QYVYLQAKFPHFELEKVVLV 100
MG2 pfam01835
MG2 domain; This is the MG2 (macroglobulin) domain of alpha-2-macroglobulin in eukaryotes. ...
 133-227 7.73e-19

MG2 domain; This is the MG2 (macroglobulin) domain of alpha-2-macroglobulin in eukaryotes. Alpha-2-macroglobulins (A2Ms) are plasma proteins that trap and inhibit a broad range of proteases and are major components of the eukaryotic innate immune system. However, A2M-like proteins were identified in pathogenically invasive bacteria and species that colonize higher eukaryotes. This domain is found in eukaryotic and bacterial proteins. In human A2Ms, this domain is termed macroglobulin-like (MG) domain 2 and in Salmonella enterica ser A2Ms, this is domain 4.


Pssm-ID: 426464 [Multi-domain]  Cd Length: 95  Bit Score: 80.05  E-value: 7.73e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340745359  133 SLFVQTDKSVYTPQQPVKVRVYSVNDDLEPATR-ETVLTFIDPEGSQVDTIEG-NNLTGIASFpDFEIPSNPKHGRWTVK 210
Cdd:pfam01835   1 RAFVYTDRGIYRPGETVHFKGLLRDQDLRPLAGlPVTLTVTDPDGNEVRRLPLtTDEFGGFSG-SFPLPETAPTGTYTVV 79

                          90
                  ....*....|....*..
gi 340745359  211 AkYREDASKTGTTYFEV 227
Cdd:pfam01835  80 L-RDGAGGSLGSGSFRV 95
ANATO cd00017
Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments ...
 268-336 4.07e-18

Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to repeats in fibulins.


Pssm-ID: 237984  Cd Length: 70  Bit Score: 77.50  E-value: 4.07e-18
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340745359 268 KINEQASTYKHPMIKKCCYDGARYNI-HETCVQRAARVKIGPICVKAFTLCCNMAHQILENSTFKHIHLS 336
Cdd:cd00017    1 KNSEKAAQYKDKELRKCCLDGMRENPmGQTCEERAAYITDGKECRKAFLECCVYAEELRDEEREDGLGLA 70
ANATO pfam01821
Anaphylotoxin-like domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated ...
 284-318 1.73e-12

Anaphylotoxin-like domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to a three-fold repeat in fibulins.


Pssm-ID: 460347  Cd Length: 36  Bit Score: 60.75  E-value: 1.73e-12
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 340745359  284 CCYDGARYN-IHETCVQRAARVKIGPICVKAFTLCC 318
Cdd:pfam01821   1 CCLDGMKRNpMGRSCEQRAARIKEGPRCRKAFLQCC 36
ANATO smart00104
Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments ...
 284-318 1.56e-07

Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to a three-fold repeat in fibulins.


Pssm-ID: 197517  Cd Length: 35  Bit Score: 46.94  E-value: 1.56e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 340745359   284 CCYDGARYNI-HETCVQRAARVKIGPiCVKAFTLCC 318
Cdd:smart00104   1 CCADGMRLAPmGETCEERAARINSGD-CRKAFLQCC 35
 
Name Accession Description Interval E-value
MG1 pfam17790
Macroglobulin domain MG1; This entry represents the N-terminal macroglobulin domain found in ...
 28-127 3.13e-20

Macroglobulin domain MG1; This entry represents the N-terminal macroglobulin domain found in complement proteins C3, C4 and C5.


Pssm-ID: 465508  Cd Length: 101  Bit Score: 84.32  E-value: 3.13e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340745359   28 EQTYIISTPIVFRVGAPENVTVQAHGHTEAFDTTVSVKSYPDENVRYSFSTVNLSPENKFQNTAILTIQAKQLSEGQNSF 107
Cdd:pfam17790   1 EPLYLLTAPNVLRVESEENIVVEAHGYTAPVEVTITVMDFPDKKALLASTSVTLNSDNNYQALVTIKIPAKLFRKDRKGK 80

                          90       100
                  ....*....|....*....|
gi 340745359  108 SNSYLEVVSKHFAKLEIVPI 127
Cdd:pfam17790  81 QYVYLQAKFPHFELEKVVLV 100
MG2 pfam01835
MG2 domain; This is the MG2 (macroglobulin) domain of alpha-2-macroglobulin in eukaryotes. ...
 133-227 7.73e-19

MG2 domain; This is the MG2 (macroglobulin) domain of alpha-2-macroglobulin in eukaryotes. Alpha-2-macroglobulins (A2Ms) are plasma proteins that trap and inhibit a broad range of proteases and are major components of the eukaryotic innate immune system. However, A2M-like proteins were identified in pathogenically invasive bacteria and species that colonize higher eukaryotes. This domain is found in eukaryotic and bacterial proteins. In human A2Ms, this domain is termed macroglobulin-like (MG) domain 2 and in Salmonella enterica ser A2Ms, this is domain 4.


Pssm-ID: 426464 [Multi-domain]  Cd Length: 95  Bit Score: 80.05  E-value: 7.73e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340745359  133 SLFVQTDKSVYTPQQPVKVRVYSVNDDLEPATR-ETVLTFIDPEGSQVDTIEG-NNLTGIASFpDFEIPSNPKHGRWTVK 210
Cdd:pfam01835   1 RAFVYTDRGIYRPGETVHFKGLLRDQDLRPLAGlPVTLTVTDPDGNEVRRLPLtTDEFGGFSG-SFPLPETAPTGTYTVV 79

                          90
                  ....*....|....*..
gi 340745359  211 AkYREDASKTGTTYFEV 227
Cdd:pfam01835  80 L-RDGAGGSLGSGSFRV 95
ANATO cd00017
Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments ...
 268-336 4.07e-18

Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to repeats in fibulins.


Pssm-ID: 237984  Cd Length: 70  Bit Score: 77.50  E-value: 4.07e-18
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340745359 268 KINEQASTYKHPMIKKCCYDGARYNI-HETCVQRAARVKIGPICVKAFTLCCNMAHQILENSTFKHIHLS 336
Cdd:cd00017    1 KNSEKAAQYKDKELRKCCLDGMRENPmGQTCEERAAYITDGKECRKAFLECCVYAEELRDEEREDGLGLA 70
ANATO pfam01821
Anaphylotoxin-like domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated ...
 284-318 1.73e-12

Anaphylotoxin-like domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to a three-fold repeat in fibulins.


Pssm-ID: 460347  Cd Length: 36  Bit Score: 60.75  E-value: 1.73e-12
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 340745359  284 CCYDGARYN-IHETCVQRAARVKIGPICVKAFTLCC 318
Cdd:pfam01821   1 CCLDGMKRNpMGRSCEQRAARIKEGPRCRKAFLQCC 36
ANATO smart00104
Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments ...
 284-318 1.56e-07

Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to a three-fold repeat in fibulins.


Pssm-ID: 197517  Cd Length: 35  Bit Score: 46.94  E-value: 1.56e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 340745359   284 CCYDGARYNI-HETCVQRAARVKIGPiCVKAFTLCC 318
Cdd:smart00104   1 CCADGMRLAPmGETCEERAARINSGD-CRKAFLQCC 35
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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