Skor1 SKI family transcriptional corepressor 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Skor1provided by MGI
Official Full Name: SKI family transcriptional corepressor 1provided by MGI
Primary source: MGI:MGI:2443473
See related: Ensembl:ENSMUSG00000022245 AllianceGenome:MGI:2443473
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Corl1; Lbxcor1; C230094B15Rik
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and SMAD binding activity. Acts upstream of or within negative regulation of DNA-templated transcription. Located in nucleus. Part of transcription regulator complex. Is expressed in bladder; central nervous system; dorsal root ganglion; and lung. Orthologous to human SKOR1 (SKI family transcriptional corepressor 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in CNS E14 (RPKM 2.7), whole brain E14.5 (RPKM 2.5) and 4 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 B; 9 33.96 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (63045446..63056243, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (63138164..63148961, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NK-derived exosome miR-1249-3p inhibits Mycobacterium tuberculosis survival in macrophages by targeting SKOR1.
Title: NK-derived exosome miR-1249-3p inhibits Mycobacterium tuberculosis survival in macrophages by targeting SKOR1.
SKOR1 mediates FER kinase-dependent invasive growth of breast cancer cells.
Title: SKOR1 mediates FER kinase-dependent invasive growth of breast cancer cells.
Our data show that mCORL2 and drosophila CORL share functions while mCORL1 has diverged which reinforces the current working hypothesis that neofunctionalization of a new gene can be achieved with a handful of advantageous amino acid changes in a highly conserved functional domain.
Title: Transgenic Analyses in Drosophila Reveal That mCORL1 Is Functionally Distinct from mCORL2 and dCORL.
Corl1 interacted with Lbx1 and cooperatively repressed transcription, suggesting that it acts as a transcriptional corepressor for Lbx1 in regulating cell fate determination in the dorsal spinal cord.
Title: Corl1, a novel neuronal lineage-specific transcriptional corepressor for the homeodomain transcription factor Lbx1.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AV273001 (e-PCR)
- UniSTS:179921

Lbxcor1 (e-PCR), detects polymorphism
- UniSTS:502771

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables SMAD binding	IBA Inferred from Biological aspect of Ancestor more info
enables SMAD binding	IEA Inferred from Electronic Annotation more info
enables SMAD binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific double-stranded DNA binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in negative regulation of BMP signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of BMP signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of BMP signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info
part_of transcription regulator complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: SKI family transcriptional corepressor 1

Names: Lbx1 corepressor 1; fussel-15 homolog; ladybird homeobox 1 homolog corepressor 1; ladybird homeobox corepressor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001163755.1 → NP_001157227.1 SKI family transcriptional corepressor 1 isoform 2

See identical proteins and their annotated locations for NP_001157227.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate splice site in the 5' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.

Source sequence(s)

AC159821, AC160392, BC138063

Consensus CDS

CCDS52829.1

UniProtKB/Swiss-Prot

Q8BX46

Related

ENSMUSP00000113924.2, ENSMUST00000119146.8

Conserved Domains (3) summary

smart01046
Location:152 → 244

c-SKI_SMAD_bind; c-SKI Smad4 binding domain

pfam02437
Location:47 → 140

Ski_Sno; SKI/SNO/DAC family

cl23720
Location:815 → 913

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
NM_001163757.1 → NP_001157229.1 SKI family transcriptional corepressor 1 isoform 3

See identical proteins and their annotated locations for NP_001157229.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate splice site in the 5' and 3' coding regions, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.

Source sequence(s)

AC159821, AC160392, AK134840

UniProtKB/Swiss-Prot

Q8BX46

Conserved Domains (3) summary

smart01046
Location:152 → 244

c-SKI_SMAD_bind; c-SKI Smad4 binding domain

pfam02437
Location:47 → 140

Ski_Sno; SKI/SNO/DAC family

cl23720
Location:815 → 880

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
NM_001163758.1 → NP_001157230.1 SKI family transcriptional corepressor 1 isoform 4

See identical proteins and their annotated locations for NP_001157230.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (4) has a shorter N-terminus compared to isoform 1.

Source sequence(s)

AC159821, AC160392, AK029916

Consensus CDS

CCDS52828.1

UniProtKB/TrEMBL

D3YX64

Related

ENSMUSP00000112312.3, ENSMUST00000116613.9

Conserved Domains (3) summary

smart01046
Location:141 → 233

c-SKI_SMAD_bind; c-SKI Smad4 binding domain

pfam02437
Location:36 → 129

Ski_Sno; SKI/SNO/DAC family

pfam15236
Location:811 → 895

CCDC66; Coiled-coil domain-containing protein 66
NM_172446.3 → NP_766034.2 SKI family transcriptional corepressor 1 isoform 1

See identical proteins and their annotated locations for NP_766034.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AC159821, AK049035

Consensus CDS

CCDS23268.1

UniProtKB/Swiss-Prot

B2RQS8, Q3UYA4, Q5W8I2, Q8BX46, Q8C0T2

Related

ENSMUSP00000055037.8, ENSMUST00000055281.8

Conserved Domains (3) summary

smart01046
Location:180 → 272

c-SKI_SMAD_bind; c-SKI Smad4 binding domain

pfam02437
Location:75 → 168

Ski_Sno; SKI/SNO/DAC family

cl23720
Location:843 → 941

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

63045446..63056243 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006510910.5 → XP_006510973.1 SKI family transcriptional corepressor 1 isoform X1

See identical proteins and their annotated locations for XP_006510973.1

UniProtKB/TrEMBL

D3YX64

Conserved Domains (3) summary

smart01046
Location:141 → 233

c-SKI_SMAD_bind; c-SKI Smad4 binding domain

pfam02437
Location:36 → 129

Ski_Sno; SKI/SNO/DAC family

pfam15236
Location:811 → 895

CCDC66; Coiled-coil domain-containing protein 66
XM_006510909.5 → XP_006510972.1 SKI family transcriptional corepressor 1 isoform X1

See identical proteins and their annotated locations for XP_006510972.1

UniProtKB/TrEMBL

D3YX64

Conserved Domains (3) summary

smart01046
Location:141 → 233

c-SKI_SMAD_bind; c-SKI Smad4 binding domain

pfam02437
Location:36 → 129

Ski_Sno; SKI/SNO/DAC family

pfam15236
Location:811 → 895

CCDC66; Coiled-coil domain-containing protein 66