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Conserved domains on  [gi|255683429|ref|NP_001157227|]
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SKI family transcriptional corepressor 1 isoform 2 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DHD_Skor cd21080
Dachshund-homology domain found in SKI family transcriptional corepressors, Skor1, Skor2 and ...
 49-139 1.64e-61

Dachshund-homology domain found in SKI family transcriptional corepressors, Skor1, Skor2 and similar proteins; Skor1, also known as functional Smad-suppressing element on chromosome 15 (Fussel-15), LBX1 corepressor 1, or ladybird homeobox corepressor 1, acts as a transcriptional corepressor of LBX1 and inhibits BMP signaling. Skor2, also known as functional Smad-suppressing element on chromosome 18 (Fussel-18), LBX1 corepressor 1-like protein, or ladybird homeobox corepressor 1-like protein, exhibits transcriptional repressor activity. It acts as a transforming growth factor-beta (TGF-beta) antagonist in the nervous system. The Dachshund-homology domain (DHD), also known as the N-terminal Ski/Sno/Dac domain, adopts a mixed alpha/beta structure containing a helix-turn-helix motif, similar to features found in the forkhead/winged-helix family of DNA binding proteins. It contains a conserved CLPQ motif and can bind co-factors. Its structure suggests that it may also bind DNA.


:

Pssm-ID: 410783  Cd Length: 91  Bit Score: 203.06  E-value: 1.64e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255683429  49 VGETSLYGVPIVSLVIDGQERLCLAQISNTLLKNYSYNEIHNRRVALGITCVQCTPVQLEILRRAGAMPISSRRCGMITK 128
Cdd:cd21080    1 VGTVILYGVPIVSLVIDGQERLCLAQISNTLLKDYSYNEIHNRRVALGITCVQCTPVQLEILRRAGAMPISSRRCGMITK 80

                         90
                 ....*....|.
gi 255683429 129 REAERLCKSFL 139
Cdd:cd21080   81 REAERLCKSFL 91
c-SKI_SMAD_bind smart01046
c-SKI Smad4 binding domain; c-SKI is an oncoprotein that inhibits TGF-beta signaling through ...
 152-244 1.78e-47

c-SKI Smad4 binding domain; c-SKI is an oncoprotein that inhibits TGF-beta signaling through interaction with Smad proteins. This domain binds to Smad4.


:

Pssm-ID: 198114  Cd Length: 95  Bit Score: 163.69  E-value: 1.78e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255683429   152 AFDVVHECAWGSRGSFIPARYNSSRAKCIKCGYCSMYFSPNKFIFHSHRTPDAKYTQ--PDAANFNSWRRHLKLSDKSAT 229
Cdd:smart01046   1 SFRVYHECFGKCQGLFVPELYSSPDAPCIQCLECRGMFSPQKFVMHSHRSPEKRTCHwgFDSANWRSYLHVAKDYGTEER 80

                           90
                   ....*....|....*
gi 255683429   230 DELSHAWEDVKAMFN 244
Cdd:smart01046  81 EKLEQLLEEMKEKFN 95
OmpH pfam03938
Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH ...
 832-907 1.08e-04

Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH among others. Skp (OmpH) has been characterized as a molecular chaperone that interacts with unfolded proteins as they emerge in the periplasm from the Sec translocation machinery.


:

Pssm-ID: 461098 [Multi-domain]  Cd Length: 140  Bit Score: 43.33  E-value: 1.08e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255683429  832 AREELQKLLLE-QMELrKKLEREFQSLKDNFQDQMKRELAYREE-------MVQQLQIVRDTLCNELDQER-KARYAIQQ 902
Cdd:pfam03938  20 AQAQLEKKFKKrQAEL-EAKQKELQKLYEELQKDGALLEEEREEkeqelqkKEQELQQLQQKAQQELQKKQqELLQPIQD 98


                  ....*
gi 255683429  903 KLKEA 907
Cdd:pfam03938  99 KINKA 103
 
Name Accession Description Interval E-value
DHD_Skor cd21080
Dachshund-homology domain found in SKI family transcriptional corepressors, Skor1, Skor2 and ...
 49-139 1.64e-61

Dachshund-homology domain found in SKI family transcriptional corepressors, Skor1, Skor2 and similar proteins; Skor1, also known as functional Smad-suppressing element on chromosome 15 (Fussel-15), LBX1 corepressor 1, or ladybird homeobox corepressor 1, acts as a transcriptional corepressor of LBX1 and inhibits BMP signaling. Skor2, also known as functional Smad-suppressing element on chromosome 18 (Fussel-18), LBX1 corepressor 1-like protein, or ladybird homeobox corepressor 1-like protein, exhibits transcriptional repressor activity. It acts as a transforming growth factor-beta (TGF-beta) antagonist in the nervous system. The Dachshund-homology domain (DHD), also known as the N-terminal Ski/Sno/Dac domain, adopts a mixed alpha/beta structure containing a helix-turn-helix motif, similar to features found in the forkhead/winged-helix family of DNA binding proteins. It contains a conserved CLPQ motif and can bind co-factors. Its structure suggests that it may also bind DNA.


Pssm-ID: 410783  Cd Length: 91  Bit Score: 203.06  E-value: 1.64e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255683429  49 VGETSLYGVPIVSLVIDGQERLCLAQISNTLLKNYSYNEIHNRRVALGITCVQCTPVQLEILRRAGAMPISSRRCGMITK 128
Cdd:cd21080    1 VGTVILYGVPIVSLVIDGQERLCLAQISNTLLKDYSYNEIHNRRVALGITCVQCTPVQLEILRRAGAMPISSRRCGMITK 80

                         90
                 ....*....|.
gi 255683429 129 REAERLCKSFL 139
Cdd:cd21080   81 REAERLCKSFL 91
c-SKI_SMAD_bind smart01046
c-SKI Smad4 binding domain; c-SKI is an oncoprotein that inhibits TGF-beta signaling through ...
 152-244 1.78e-47

c-SKI Smad4 binding domain; c-SKI is an oncoprotein that inhibits TGF-beta signaling through interaction with Smad proteins. This domain binds to Smad4.


Pssm-ID: 198114  Cd Length: 95  Bit Score: 163.69  E-value: 1.78e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255683429   152 AFDVVHECAWGSRGSFIPARYNSSRAKCIKCGYCSMYFSPNKFIFHSHRTPDAKYTQ--PDAANFNSWRRHLKLSDKSAT 229
Cdd:smart01046   1 SFRVYHECFGKCQGLFVPELYSSPDAPCIQCLECRGMFSPQKFVMHSHRSPEKRTCHwgFDSANWRSYLHVAKDYGTEER 80

                           90
                   ....*....|....*
gi 255683429   230 DELSHAWEDVKAMFN 244
Cdd:smart01046  81 EKLEQLLEEMKEKFN 95
Ski_Sno pfam02437
SKI/SNO/DAC family; This family contains a presumed domain that is about 100 amino acids long. ...
 47-140 4.28e-43

SKI/SNO/DAC family; This family contains a presumed domain that is about 100 amino acids long. All members of this family contain a conserved CLPQ motif. The c-ski proto-oncogene has been shown to influence proliferation, morphological transformation and myogenic differentiation. Sno, a Ski proto-oncogene homolog, is expressed in two isoforms and plays a role in the response to proliferation stimuli. Dachshund also contains this domain. It is involved in various aspects of development.


Pssm-ID: 460558  Cd Length: 100  Bit Score: 151.66  E-value: 4.28e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255683429   47 NQVGETSLYGVPIVSLVIDGQERLCLAQISNTLLKNYSYNEIHNRRVALGITCVQCTPVQLEILRRAGAMPISSRRCGMI 126
Cdd:pfam02437   7 NERMETMLEGEVISCFMVGGEERLCLPQILNTLLKDFSLTQINTVCDELIITCVRCTPEQLEILKLLGILPPSVRRCGLI 86

                          90
                  ....*....|....
gi 255683429  127 TKREAERLCKSFLG 140
Cdd:pfam02437  87 TKTDAERLCDALLH 100
c-SKI_SMAD_bind pfam08782
c-SKI Smad4 binding domain; c-SKI is an oncoprotein that inhibits TGF-beta signaling through ...
 152-243 3.26e-40

c-SKI Smad4 binding domain; c-SKI is an oncoprotein that inhibits TGF-beta signaling through interaction with Smad proteins. This domain binds to Smad4


Pssm-ID: 462602  Cd Length: 94  Bit Score: 143.18  E-value: 3.26e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255683429  152 AFDVVHECAWGSRGSFIPARYNSSRAKCIKCGYCSMYFSPNKFIFHSHRTPDAKYTQ--PDAANfnsWRRHLKLSDKSAT 229
Cdd:pfam08782   1 SFEVYHECFGKCRGLFVPELYTSPRAACIQCLECRLMFSPQKFVFHSHRSPENRTCHwgFDSAN---WRAYLHLARYLDT 77

                          90
                  ....*....|....*..
gi 255683429  230 ---DELSHAWEDVKAMF 243
Cdd:pfam08782  78 pdrEKLEQLLEDLKAKF 94
OmpH pfam03938
Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH ...
 832-907 1.08e-04

Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH among others. Skp (OmpH) has been characterized as a molecular chaperone that interacts with unfolded proteins as they emerge in the periplasm from the Sec translocation machinery.


Pssm-ID: 461098 [Multi-domain]  Cd Length: 140  Bit Score: 43.33  E-value: 1.08e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255683429  832 AREELQKLLLE-QMELrKKLEREFQSLKDNFQDQMKRELAYREE-------MVQQLQIVRDTLCNELDQER-KARYAIQQ 902
Cdd:pfam03938  20 AQAQLEKKFKKrQAEL-EAKQKELQKLYEELQKDGALLEEEREEkeqelqkKEQELQQLQQKAQQELQKKQqELLQPIQD 98


                  ....*
gi 255683429  903 KLKEA 907
Cdd:pfam03938  99 KINKA 103
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 825-906 5.66e-04

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 42.60  E-value: 5.66e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255683429 825 EKDIENLARE--ELQKLLLEQMELRKKLEREFQSLKDnfqdqmkrELAYREEMVQQLQIVRDTLCNELDQERKARYAIQQ 902
Cdd:COG1579   95 QKEIESLKRRisDLEDEILELMERIEELEEELAELEA--------ELAELEAELEEKKAELDEELAELEAELEELEAERE 166


                 ....
gi 255683429 903 KLKE 906
Cdd:COG1579  167 ELAA 170
Spc7 smart00787
Spc7 kinetochore protein; This domain is found in cell division proteins which are required ...
 830-927 8.07e-04

Spc7 kinetochore protein; This domain is found in cell division proteins which are required for kinetochore-spindle association.


Pssm-ID: 197874 [Multi-domain]  Cd Length: 312  Bit Score: 42.70  E-value: 8.07e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255683429   830 NLAREELQKLLLEQMELRKK---LEREFQSLKDNFQDQMKRELAYREEmVQQLQIVRDTlCNELDqERKARyaiqqKLKE 906
Cdd:smart00787 207 DRAKEKLKKLLQEIMIKVKKleeLEEELQELESKIEDLTNKKSELNTE-IAEAEKKLEQ-CRGFT-FKEIE-----KLKE 278

                           90       100
                   ....*....|....*....|.
gi 255683429   907 AHDALHHFSckMLTPRHCTGN 927
Cdd:smart00787 279 QLKLLQSLT--GWKITKLSGN 297
PRK00409 PRK00409
recombination and DNA strand exchange inhibitor protein; Reviewed
 810-912 3.68e-03

recombination and DNA strand exchange inhibitor protein; Reviewed


Pssm-ID: 234750 [Multi-domain]  Cd Length: 782  Bit Score: 40.97  E-value: 3.68e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255683429 810 GEDGLTLDvtgtQLVEKdIENLARE------ELQKLLLEQMELRKKLEREFQSLKDNFQDQMKR-ELAYREEmVQQLQIV 882
Cdd:PRK00409 512 GEDKEKLN----ELIAS-LEELEREleqkaeEAEALLKEAEKLKEELEEKKEKLQEEEDKLLEEaEKEAQQA-IKEAKKE 585

                         90       100       110
                 ....*....|....*....|....*....|..
gi 255683429 883 RDTLCNELDQERKARYAIQ--QKLKEAHDALH 912
Cdd:PRK00409 586 ADEIIKELRQLQKGGYASVkaHELIEARKRLN 617
 
Name Accession Description Interval E-value
DHD_Skor cd21080
Dachshund-homology domain found in SKI family transcriptional corepressors, Skor1, Skor2 and ...
 49-139 1.64e-61

Dachshund-homology domain found in SKI family transcriptional corepressors, Skor1, Skor2 and similar proteins; Skor1, also known as functional Smad-suppressing element on chromosome 15 (Fussel-15), LBX1 corepressor 1, or ladybird homeobox corepressor 1, acts as a transcriptional corepressor of LBX1 and inhibits BMP signaling. Skor2, also known as functional Smad-suppressing element on chromosome 18 (Fussel-18), LBX1 corepressor 1-like protein, or ladybird homeobox corepressor 1-like protein, exhibits transcriptional repressor activity. It acts as a transforming growth factor-beta (TGF-beta) antagonist in the nervous system. The Dachshund-homology domain (DHD), also known as the N-terminal Ski/Sno/Dac domain, adopts a mixed alpha/beta structure containing a helix-turn-helix motif, similar to features found in the forkhead/winged-helix family of DNA binding proteins. It contains a conserved CLPQ motif and can bind co-factors. Its structure suggests that it may also bind DNA.


Pssm-ID: 410783  Cd Length: 91  Bit Score: 203.06  E-value: 1.64e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255683429  49 VGETSLYGVPIVSLVIDGQERLCLAQISNTLLKNYSYNEIHNRRVALGITCVQCTPVQLEILRRAGAMPISSRRCGMITK 128
Cdd:cd21080    1 VGTVILYGVPIVSLVIDGQERLCLAQISNTLLKDYSYNEIHNRRVALGITCVQCTPVQLEILRRAGAMPISSRRCGMITK 80

                         90
                 ....*....|.
gi 255683429 129 REAERLCKSFL 139
Cdd:cd21080   81 REAERLCKSFL 91
c-SKI_SMAD_bind smart01046
c-SKI Smad4 binding domain; c-SKI is an oncoprotein that inhibits TGF-beta signaling through ...
 152-244 1.78e-47

c-SKI Smad4 binding domain; c-SKI is an oncoprotein that inhibits TGF-beta signaling through interaction with Smad proteins. This domain binds to Smad4.


Pssm-ID: 198114  Cd Length: 95  Bit Score: 163.69  E-value: 1.78e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255683429   152 AFDVVHECAWGSRGSFIPARYNSSRAKCIKCGYCSMYFSPNKFIFHSHRTPDAKYTQ--PDAANFNSWRRHLKLSDKSAT 229
Cdd:smart01046   1 SFRVYHECFGKCQGLFVPELYSSPDAPCIQCLECRGMFSPQKFVMHSHRSPEKRTCHwgFDSANWRSYLHVAKDYGTEER 80

                           90
                   ....*....|....*
gi 255683429   230 DELSHAWEDVKAMFN 244
Cdd:smart01046  81 EKLEQLLEEMKEKFN 95
Ski_Sno pfam02437
SKI/SNO/DAC family; This family contains a presumed domain that is about 100 amino acids long. ...
 47-140 4.28e-43

SKI/SNO/DAC family; This family contains a presumed domain that is about 100 amino acids long. All members of this family contain a conserved CLPQ motif. The c-ski proto-oncogene has been shown to influence proliferation, morphological transformation and myogenic differentiation. Sno, a Ski proto-oncogene homolog, is expressed in two isoforms and plays a role in the response to proliferation stimuli. Dachshund also contains this domain. It is involved in various aspects of development.


Pssm-ID: 460558  Cd Length: 100  Bit Score: 151.66  E-value: 4.28e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255683429   47 NQVGETSLYGVPIVSLVIDGQERLCLAQISNTLLKNYSYNEIHNRRVALGITCVQCTPVQLEILRRAGAMPISSRRCGMI 126
Cdd:pfam02437   7 NERMETMLEGEVISCFMVGGEERLCLPQILNTLLKDFSLTQINTVCDELIITCVRCTPEQLEILKLLGILPPSVRRCGLI 86

                          90
                  ....*....|....
gi 255683429  127 TKREAERLCKSFLG 140
Cdd:pfam02437  87 TKTDAERLCDALLH 100
c-SKI_SMAD_bind pfam08782
c-SKI Smad4 binding domain; c-SKI is an oncoprotein that inhibits TGF-beta signaling through ...
 152-243 3.26e-40

c-SKI Smad4 binding domain; c-SKI is an oncoprotein that inhibits TGF-beta signaling through interaction with Smad proteins. This domain binds to Smad4


Pssm-ID: 462602  Cd Length: 94  Bit Score: 143.18  E-value: 3.26e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255683429  152 AFDVVHECAWGSRGSFIPARYNSSRAKCIKCGYCSMYFSPNKFIFHSHRTPDAKYTQ--PDAANfnsWRRHLKLSDKSAT 229
Cdd:pfam08782   1 SFEVYHECFGKCRGLFVPELYTSPRAACIQCLECRLMFSPQKFVFHSHRSPENRTCHwgFDSAN---WRAYLHLARYLDT 77

                          90
                  ....*....|....*..
gi 255683429  230 ---DELSHAWEDVKAMF 243
Cdd:pfam08782  78 pdrEKLEQLLEDLKAKF 94
DHD_Ski_Sno_Dac cd21074
Dachshund-homology domain found in the Ski/Sno/Dac family of transcriptional regulators; The ...
 49-136 1.02e-33

Dachshund-homology domain found in the Ski/Sno/Dac family of transcriptional regulators; The Dachshund-homology domain (DHD), also known as the N-terminal Ski/Sno/Dac domain, adopts a mixed alpha/beta structure containing a helix-turn-helix motif, similar to features found in the forkhead/winged-helix family of DNA binding proteins. It contains a conserved CLPQ motif and can bind co-factors. Its structure suggests that it may also bind DNA. Members of this family include the Ski protein, Ski-like protein (Sno), and Dachshund proteins. Ski may play a role in terminal differentiation of skeletal muscle cells but not in the determination of cells to the myogenic lineage. It functions as a repressor of transforming growth factor-beta (TGF-beta) signaling. Ski-like protein, also known as SKIL or Sno, is the ski proto-oncogene homolog. It may have regulatory roles in cell division or differentiation in response to extracellular signals. Dachshund proteins are essential components of a regulatory network controlling cell fate determination. They have been implicated in eye, limb, brain, and muscle development.


Pssm-ID: 410781  Cd Length: 88  Bit Score: 124.33  E-value: 1.02e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255683429  49 VGETSLYGVPIVSLVIDGQERLCLAQISNTLLKNYSYNEIHNRRVALGITCVQCTPVQLEILRRAGAMPISSRRCGMITK 128
Cdd:cd21074    1 LVTSTLEGKRIAGFEIDGEERLCLPQILNLVLKDFVQTQIHNRCTKLKIICTRCDQEQLKILKRLGILPPKAKSCGLISK 80


                 ....*...
gi 255683429 129 REAERLCK 136
Cdd:cd21074   81 SDAERLLN 88
DHD_Ski_Sno cd21079
Dachshund-homology domain found in Ski, Ski-like protein (Sno), and similar proteins; Ski may ...
 51-139 8.84e-26

Dachshund-homology domain found in Ski, Ski-like protein (Sno), and similar proteins; Ski may play a role in terminal differentiation of skeletal muscle cells but not in the determination of cells to the myogenic lineage. It functions as a repressor of transforming growth factor-beta (TGF-beta) signaling. Ski-like protein, also known as SKIL or Sno, is the ski proto-oncogene homolog. It may have regulatory roles in cell division or differentiation in response to extracellular signals. The Dachshund-homology domain (DHD), also known as the N-terminal Ski/Sno/Dac domain, adopts a mixed alpha/beta structure containing a helix-turn-helix motif, similar to features found in the forkhead/winged-helix family of DNA binding proteins. It contains a conserved CLPQ motif and can bind co-factors. Its structure suggests that it may also bind DNA.


Pssm-ID: 410782  Cd Length: 91  Bit Score: 101.87  E-value: 8.84e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255683429  51 ETSLYGVPIVSLVIDGQERLCLAQISNTLLKNYSYNEIHNRRVALGITCVQCTPVQLEILRRAGAMPISSRRCGMITKRE 130
Cdd:cd21079    3 ETLLEGETIACFVVGGEKRLCLPQILNTVLRDFSLQQINRVCDDLHIYCSRCTPEQLETLKLAGILPPSAPSCGLITKTD 82


                 ....*....
gi 255683429 131 AERLCKSFL 139
Cdd:cd21079   83 AERLCSALL 91
DHD_Ski cd21083
Dachshund-homology domain found in Ski and similar proteins; Ski may play a role in terminal ...
 51-139 8.16e-18

Dachshund-homology domain found in Ski and similar proteins; Ski may play a role in terminal differentiation of skeletal muscle cells but not in the determination of cells to the myogenic lineage. It functions as a repressor of transforming growth factor-beta (TGF-beta) signaling. The Dachshund-homology domain (DHD), also known as the N-terminal Ski/Sno/Dac domain, adopts a mixed alpha/beta structure containing a helix-turn-helix motif, similar to features found in the forkhead/winged-helix family of DNA binding proteins. It contains a conserved CLPQ motif and can bind co-factors. Its structure suggests that it may also bind DNA.


Pssm-ID: 410786  Cd Length: 102  Bit Score: 79.73  E-value: 8.16e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255683429  51 ETSLYGVPIVSLVIDGQERLCLAQISNTLLKNYSYNEIHNRRVALGITCVQCTPVQLEILRRAGAMPISSRRCGMITKRE 130
Cdd:cd21083   12 ETILEGETISCFVVGGEKRLCLPQILNSVLRDFSLQQINSVCDELHIYCSRCTADQLEILKVMGILPFSAPSCGLITKTD 91


                 ....*....
gi 255683429 131 AERLCKSFL 139
Cdd:cd21083   92 AERLCNALL 100
DHD_Sno cd21084
Dachshund-homology domain found in Ski-like protein (Sno) and similar proteins; Ski-like ...
 51-139 7.42e-17

Dachshund-homology domain found in Ski-like protein (Sno) and similar proteins; Ski-like protein, also known as SKIL, Ski-related oncogene (Sno), or Ski-related protein, is the ski proto-oncogene homolog. It may have regulatory roles in cell division or differentiation in response to extracellular signals. The Dachshund-homology domain (DHD), also known as the N-terminal Ski/Sno/Dac domain, adopts a mixed alpha/beta structure containing a helix-turn-helix motif, similar to features found in the forkhead/winged-helix family of DNA binding proteins. It contains a conserved CLPQ motif and can bind co-factors. Its structure suggests that it may also bind DNA.


Pssm-ID: 410787  Cd Length: 100  Bit Score: 76.92  E-value: 7.42e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255683429  51 ETSLYGVPIVSLVIDGQERLCLAQISNTLLKNYSYNEIHNRRVALGITCVQCTPVQLEILRRAGAMPISSRRCGMITKRE 130
Cdd:cd21084   10 QTVLEGESISCFMVGGEKRLCLPQVLNSVLRDFSLQQINTVCDELYIYCSRCTSDQLHILKVLGILPFNAPSCGLITLTD 89


                 ....*....
gi 255683429 131 AERLCKSFL 139
Cdd:cd21084   90 AQRLCNALL 98
DHD_SKIDA1 cd21082
Dachshund-homology domain found in SKI/DACH domain-containing protein 1 (SKIDA1) and similar ...
 50-138 2.53e-09

Dachshund-homology domain found in SKI/DACH domain-containing protein 1 (SKIDA1) and similar proteins; SKIDA1 is also known as protein DLN-1. Its biological function remains unclear. The Dachshund-homology domain (DHD), also known as the N-terminal Ski/Sno/Dac domain, adopts a mixed alpha/beta structure containing a helix-turn-helix motif, similar to features found in the forkhead/winged-helix family of DNA binding proteins. It contains a conserved CLPQ motif and can bind co-factors. Its structure suggests that it may also bind DNA.


Pssm-ID: 410785  Cd Length: 91  Bit Score: 55.04  E-value: 2.53e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255683429  50 GETSLYGVPIVSLVIDGQERLCLAQISNTLLKNYSYNEIHNRRVALGITCVQCTPVQLEILRRAGAMPISSRRCGMITKR 129
Cdd:cd21082    2 GREEVHGVELGYLYINGKQMFALSQVFTDLLPNTPRTTVHKRMDRLKVKKHHCDLEELRKLKALNGIAFHAAKCTLISRE 81


                 ....*....
gi 255683429 130 EAERLCKSF 138
Cdd:cd21082   82 DVERLYSSY 90
DHD_Dac cd21081
Dachshund-homology domain found in the retinal determination protein Dachshund and similar ...
 56-134 1.24e-06

Dachshund-homology domain found in the retinal determination protein Dachshund and similar proteins; Dachshund proteins act as transcription factors involved in the regulation of organogenesis. They may be a regulator of SIX1, SIX6 and probably SIX5. The Dachshund-homology domain (DHD), also known as the N-terminal Ski/Sno/Dac domain, adopts a mixed alpha/beta structure containing a helix-turn-helix motif, similar to features found in the forkhead/winged-helix family of DNA binding proteins. It contains a conserved CLPQ motif and can bind co-factors. Its structure suggests that it may also bind DNA. It has been postulated that Dachshund proteins may bind to chromatin DNA via their DHD domains.


Pssm-ID: 410784  Cd Length: 95  Bit Score: 47.36  E-value: 1.24e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255683429  56 GVPIVSLVIDGQERLCLAQISNTLLKNY--SYNEIHNRRVALGITCVQCTPVQLEILRRAGAMPISSRRCGMITKREAER 133
Cdd:cd21081   10 GAKVAAFTVDGEELICLPQAFELFLKHLvgGLHTVYTKLKRLDITPVVCNVEQVRILRGLGAIQPGVNRCKLISRKDFDT 89


                 .
gi 255683429 134 L 134
Cdd:cd21081   90 L 90
OmpH pfam03938
Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH ...
 832-907 1.08e-04

Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH among others. Skp (OmpH) has been characterized as a molecular chaperone that interacts with unfolded proteins as they emerge in the periplasm from the Sec translocation machinery.


Pssm-ID: 461098 [Multi-domain]  Cd Length: 140  Bit Score: 43.33  E-value: 1.08e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255683429  832 AREELQKLLLE-QMELrKKLEREFQSLKDNFQDQMKRELAYREE-------MVQQLQIVRDTLCNELDQER-KARYAIQQ 902
Cdd:pfam03938  20 AQAQLEKKFKKrQAEL-EAKQKELQKLYEELQKDGALLEEEREEkeqelqkKEQELQQLQQKAQQELQKKQqELLQPIQD 98


                  ....*
gi 255683429  903 KLKEA 907
Cdd:pfam03938  99 KINKA 103
GAS pfam13851
Growth-arrest specific micro-tubule binding; This family is the highly conserved central ...
 824-903 3.25e-04

Growth-arrest specific micro-tubule binding; This family is the highly conserved central region of a number of metazoan proteins referred to as growth-arrest proteins. In mouse, Gas8 is predominantly a testicular protein, whose expression is developmentally regulated during puberty and spermatogenesis. In humans, it is absent in infertile males who lack the ability to generate gametes. The localization of Gas8 in the motility apparatus of post-meiotic gametocytes and mature spermatozoa, together with the detection of Gas8 also in cilia at the apical surfaces of epithelial cells lining the pulmonary bronchi and Fallopian tubes suggests that the Gas8 protein may have a role in the functioning of motile cellular appendages. Gas8 is a microtubule-binding protein localized to regions of dynein regulation in mammalian cells.


Pssm-ID: 464001 [Multi-domain]  Cd Length: 200  Bit Score: 42.97  E-value: 3.25e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255683429  824 VEKDIENLaREELQKLLLEQMELRKKL---EREFQSLK-----DNFQDQMKRELAY-REEMVQQLQIV---RDTLcneLD 891
Cdd:pfam13851  52 IQQENKRL-TEPLQKAQEEVEELRKQLenyEKDKQSLKnlkarLKVLEKELKDLKWeHEVLEQRFEKVereRDEL---YD 127

                          90
                  ....*....|..
gi 255683429  892 QERKARYAIQQK 903
Cdd:pfam13851 128 KFEAAIQDVQQK 139
PKK pfam12474
Polo kinase kinase; This domain family is found in eukaryotes, and is approximately 140 amino ...
 821-912 3.93e-04

Polo kinase kinase; This domain family is found in eukaryotes, and is approximately 140 amino acids in length. The family is found in association with pfam00069. Polo-like kinase 1 (Plx1) is essential during mitosis for the activation of Cdc25C, for spindle assembly, and for cyclin B degradation. This family is Polo kinase kinase (PKK) which phosphorylates Polo kinase and Polo-like kinase to activate them. PKK is a serine/threonine kinase.


Pssm-ID: 463600 [Multi-domain]  Cd Length: 139  Bit Score: 41.39  E-value: 3.93e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255683429  821 TQLV---EKDIENLAReeLQKLLLEQMELRKKLEREfQSLKDNFQDQMKRELAYREEMVQQLQIVR---DTLCNELDQER 894
Cdd:pfam12474  17 QQLKkryEKELEQLER--QQKQQIEKLEQRQTQELR-RLPKRIRAEQKKRLKMFRESLKQEKKELKqevEKLPKFQRKEA 93

                          90
                  ....*....|....*...
gi 255683429  895 KARYAIQQKLKEAHDALH 912
Cdd:pfam12474  94 KRQRKEELELEQKHEELE 111
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 825-906 5.66e-04

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 42.60  E-value: 5.66e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255683429 825 EKDIENLARE--ELQKLLLEQMELRKKLEREFQSLKDnfqdqmkrELAYREEMVQQLQIVRDTLCNELDQERKARYAIQQ 902
Cdd:COG1579   95 QKEIESLKRRisDLEDEILELMERIEELEEELAELEA--------ELAELEAELEEKKAELDEELAELEAELEELEAERE 166


                 ....
gi 255683429 903 KLKE 906
Cdd:COG1579  167 ELAA 170
Spc7 smart00787
Spc7 kinetochore protein; This domain is found in cell division proteins which are required ...
 830-927 8.07e-04

Spc7 kinetochore protein; This domain is found in cell division proteins which are required for kinetochore-spindle association.


Pssm-ID: 197874 [Multi-domain]  Cd Length: 312  Bit Score: 42.70  E-value: 8.07e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255683429   830 NLAREELQKLLLEQMELRKK---LEREFQSLKDNFQDQMKRELAYREEmVQQLQIVRDTlCNELDqERKARyaiqqKLKE 906
Cdd:smart00787 207 DRAKEKLKKLLQEIMIKVKKleeLEEELQELESKIEDLTNKKSELNTE-IAEAEKKLEQ-CRGFT-FKEIE-----KLKE 278

                           90       100
                   ....*....|....*....|.
gi 255683429   907 AHDALHHFSckMLTPRHCTGN 927
Cdd:smart00787 279 QLKLLQSLT--GWKITKLSGN 297
PspA COG1842
Phage shock protein A [Transcription, Signal transduction mechanisms];
822-915 1.25e-03

Phage shock protein A [Transcription, Signal transduction mechanisms];


Pssm-ID: 441447 [Multi-domain]  Cd Length: 217  Bit Score: 41.35  E-value: 1.25e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255683429 822 QLVEKDIENLAREELQKlLLEQMELRKKLEREFQSLKDNfQDQMKRELAYREEMVQQLQIVRDTLcneldqerKARYAIQ 901
Cdd:COG1842   76 LALEKGREDLAREALER-KAELEAQAEALEAQLAQLEEQ-VEKLKEALRQLESKLEELKAKKDTL--------KARAKAA 145

                         90
                 ....*....|....
gi 255683429 902 QKLKEAHDALHHFS 915
Cdd:COG1842  146 KAQEKVNEALSGID 159
HlpA COG2825
Periplasmic chaperone for outer membrane proteins, Skp family [Cell wall/membrane/envelope ...
 824-907 3.48e-03

Periplasmic chaperone for outer membrane proteins, Skp family [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442073 [Multi-domain]  Cd Length: 171  Bit Score: 39.43  E-value: 3.48e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255683429 824 VEKDIENLA---REELQKLLLEQMELRKKLEREFQSLKDNFQDQMKRELayrEEMVQQLQIVRDTLCNELDQER-KARYA 899
Cdd:COG2825   44 AQKKLEKEFkkrQAELQKLEKELQALQEKLQKEAATLSEEERQKKEREL---QKKQQELQRKQQEAQQDLQKRQqELLQP 120


                 ....*...
gi 255683429 900 IQQKLKEA 907
Cdd:COG2825  121 ILEKIQKA 128
PRK00409 PRK00409
recombination and DNA strand exchange inhibitor protein; Reviewed
 810-912 3.68e-03

recombination and DNA strand exchange inhibitor protein; Reviewed


Pssm-ID: 234750 [Multi-domain]  Cd Length: 782  Bit Score: 40.97  E-value: 3.68e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255683429 810 GEDGLTLDvtgtQLVEKdIENLARE------ELQKLLLEQMELRKKLEREFQSLKDNFQDQMKR-ELAYREEmVQQLQIV 882
Cdd:PRK00409 512 GEDKEKLN----ELIAS-LEELEREleqkaeEAEALLKEAEKLKEELEEKKEKLQEEEDKLLEEaEKEAQQA-IKEAKKE 585

                         90       100       110
                 ....*....|....*....|....*....|..
gi 255683429 883 RDTLCNELDQERKARYAIQ--QKLKEAHDALH 912
Cdd:PRK00409 586 ADEIIKELRQLQKGGYASVkaHELIEARKRLN 617
TPH pfam13868
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ...
 822-906 4.37e-03

Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of eukaryotic proteins. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs). The family is in the trichohyalin-plectin-homology domain.


Pssm-ID: 464007 [Multi-domain]  Cd Length: 341  Bit Score: 40.29  E-value: 4.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255683429  822 QLVEKD-IENLAREElQKLLLEQMElrKKLEREFQSLKDNFQDQMKRELAYREEMVQQL---QIVRDTLCNELDQERKAR 897
Cdd:pfam13868  27 QIAEKKrIKAEEKEE-ERRLDEMME--EERERALEEEEEKEEERKEERKRYRQELEEQIeerEQKRQEEYEEKLQEREQM 103


                  ....*....
gi 255683429  898 YAIQQKLKE 906
Cdd:pfam13868 104 DEIVERIQE 112
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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