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    MFS16 Major Facilitator Superfamily Transporter 16 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37427, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MFS16provided by FlyBase
    Official Full Name
    Major Facilitator Superfamily Transporter 16provided by FlyBase
    Primary source
    FLYBASE:FBgn0034611
    Locus tag
    Dmel_CG10069
    See related
    AllianceGenome:FB:FBgn0034611
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10069; Dmel\CG10069
    Summary
    Predicted to enable glucose 6-phosphate:phosphate antiporter activity. Predicted to be involved in gluconeogenesis and glucose-6-phosphate transport. Predicted to be located in endoplasmic reticulum membrane. Is expressed in organism. Orthologous to human SLC37A1 (solute carrier family 37 member 1) and SLC37A2 (solute carrier family 37 member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See MFS16 in Genome Data Viewer
    Location:
    57D7-57D7; 2-94 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (21282298..21285679)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (17169803..17173184)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Rad, Gem/Kir family member 3 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene SAGA-associated factor 29kDa

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Selective maintenance of Drosophila tandemly arranged duplicated genes during evolution. Quijano C, et al. Genome Biol, 2008. PMID 19087263, Free PMC Article
    2. Roles of major facilitator superfamily transporters in phosphate response in Drosophila. Bergwitz C, et al. PLoS One, 2012. PMID 22359624, Free PMC Article
    3. The Proton-Coupled Monocarboxylate Transporter Hermes Is Necessary for Autophagy during Cell Death. Velentzas PD, et al. Dev Cell, 2018 Nov 5. PMID 30318245, Free PMC Article
    4. Glial solute carrier transporters in Drosophila and mice. Featherstone DE. Glia, 2011 Sep. PMID 21732427
    5. A phylogenetic analysis between humans and D. melanogaster: A repertoire of solute carriers in humans and flies. Ceder MM, et al. Gene, 2022 Jan 30. PMID 34673204

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables glucose 6-phosphate:phosphate antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glucose 6-phosphate:phosphate antiporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in gluconeogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in glucose-6-phosphate transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    major facilitator superfamily transporter 16
    Names
    CG10069-PA
    CG10069-PB
    CG10069-PC
    CG10069-PD
    MFS16-PA
    MFS16-PB
    MFS16-PC
    MFS16-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      21282298..21285679
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_166434.2 → NP_726048.1  major facilitator superfamily transporter 16, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726048.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MLW5
      Related
      FBpp0071516
      Conserved Domains (2) summary
      cd06174
      Location:139 → 549
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      COG2271
      Location:84 → 545
      UhpC; Sugar phosphate permease [Carbohydrate transport and metabolism]

    2. NM_137726.3 → NP_611570.3  major facilitator superfamily transporter 16, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611570.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q960B6, Q9W2I6
      Related
      FBpp0071515
      Conserved Domains (2) summary
      cd06174
      Location:101 → 511
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      COG2271
      Location:46 → 507
      UhpC; Sugar phosphate permease [Carbohydrate transport and metabolism]

    3. NM_166435.2 → NP_726049.1  major facilitator superfamily transporter 16, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726049.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q960B6, Q9W2I6
      Related
      FBpp0071517
      Conserved Domains (2) summary
      cd06174
      Location:101 → 511
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      COG2271
      Location:46 → 507
      UhpC; Sugar phosphate permease [Carbohydrate transport and metabolism]

    4. NM_001299742.1 → NP_001286671.1  major facilitator superfamily transporter 16, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286671.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q960B6, Q9W2I6
      Conserved Domains (2) summary
      cd06174
      Location:101 → 511
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      COG2271
      Location:46 → 507
      UhpC; Sugar phosphate permease [Carbohydrate transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MLW5 Q8MLW5
    Q9W2I6 Q9W2I6

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