|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_SLC37A1_2 |
cd17344 |
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; ... |
47-514 |
0e+00 |
|
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 members 1 (SLC37A1) and 2 (SLC37A2) are also called sugar phosphate exchangers 1 (SPX1) and 2 (SPX2). SLC37A1 and SLC37A2 are ER-associated, Pi-linked antiporters that can transport glucose-6-phosphate (G6P) but are insensitive to chlorogenic acid, a competitive inhibitor of physiological ER G6P transport, unlike SLC37A4, the best characterized SLC37 family member and is the physiological G6P transporter (G6PT). SLC37A1 and SLC37A2 belong to the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340902 [Multi-domain] Cd Length: 400 Bit Score: 664.79 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 47 KMSVFVLTFLAYACYHMCRKPISVVKSVLQGNCSTALAA------SGQDCGYAPFDVPDATTLFGMLDSAFLFSYAIAMF 120
Cdd:cd17344 1 RGFILVLTFLAYACYHLSRKPISIVKSVLHPNCSALIPPpnivlnNTTWCGWAPFDGKNGTELLGALDSAFLFAYAIGMF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 121 ASGFVAERVSLRYFLSMGMILTGVFTYMFGIARTSNIHSLWYFIIVQIFAGIFQTTGWPGVVALVGRWFGKSKRGLIFGI 200
Cdd:cd17344 81 FSGHIGERLPLRYFLSFGMLLSGLFTALFGLGYYWNIHSLWYFVVVQILAGLFQSTGWPSVVACVGNWFGKGKRGLIMGI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 201 WNSHTSIGNILGTLIAAHYVESDWALSFVVPGIIIAAVGFLLFLFLVDQPeivgcypqagqherrvanesdveqddeeqv 280
Cdd:cd17344 161 WNSHTSVGNILGSLIAGIFVSSAWGLSFIVPGIIIAAMGVLVFLFLVEHP------------------------------ 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 281 rhndaeinyrsaptertpilprsqpeavprgrgrpislidalfiPGVVEFSLCLFFTKLVSYTFMYWLPLYIQKSSTLGP 360
Cdd:cd17344 211 --------------------------------------------PGVIEFSLCLFFAKLVSYTFLYWLPLYISNTAILSA 246
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 361 ELSADLSTLFDVGGILGAIAAGYLSDVSGMSATVCTGMLFVASPILLMYQQYGALSMTISIVLLIVVGIFVNGPYALITT 440
Cdd:cd17344 247 KKAGDLSTLFDVGGIVGGILAGYISDYTGGRATTCAAMLILAAPMLFIYNYFGQVSMTTNIVLLIVCGLLVNGPYALITT 326
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 665402485 441 SVSAELGQHSSLEGNANALATVTAIIDGTGSIGAAVGPLLAGLISTAGWQYVFHMLIAADIIAMVLLGRLVFKE 514
Cdd:cd17344 327 AVSADLGTHKSLKGNARALATVTAIIDGTGSIGAALGPLLAGLISSRGWNNVFYMLIAADVCAGLLLTRLVYKE 400
|
|
| MFS_SLC37A3 |
cd17342 |
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute ... |
50-511 |
3.82e-90 |
|
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 3 (SLC37A3) is also called sugar phosphate exchanger 3 (SPX3), and is one of four SLC37 family proteins in vertebrates. It's function and activity is unknown. The best characterized SLC37 family member is SLC37A4, also called the glucose-6-phosphate transporter (G6PT), a phosphate (Pi)-linked G6P antiporter. SLC37A3 is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340900 [Multi-domain] Cd Length: 399 Bit Score: 281.90 E-value: 3.82e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 50 VFVLTFLAYACYHMCRKPISVVKS----VLQGNCSTALAASGQDCGYAP--FDVPDATTLF-GMLDSAFLFSYAIAMFAS 122
Cdd:cd17342 4 VFILTFFSYALLHATRKTFSNVKPsisaEWTPSNSNTSIELHEETWNANplFPSQDDAALFlGVLDTIFLFSYAIGLFIS 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 123 GFVAERVSLRYFLSMGMILTGVFTYMFG-IARTSNIHSLWYFIIVQIFAGIFQTTGWPGVVALVGRWFGKSKRGLIFGIW 201
Cdd:cd17342 84 GWLGDRLNLRLVLAFGMCSSAITVFLFGvLTEWLHFYNKYLYCILWVLNGLLQSTGWPCVVAIMGNWFGKSSRGFVLGLW 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 202 NSHTSIGNILGTLIAAHYVESDWALSFVVPGIIIAAVGFLLFLFLVDQPeivgcypqagqherrvanesdveqddeeqvr 281
Cdd:cd17342 164 SACASVGNIIGALLASSVLDYGYEYAFLVTSSLLFAGAIVVFFGLLSSP------------------------------- 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 282 hndaeinyrsaptertpilprsqpeavprgrgrpislidalfiPGVVEFSLCLFFTKLVSYTFMYWLPLYIQKSSTLGPE 361
Cdd:cd17342 213 -------------------------------------------PGVIPYSLAYACLKLVNYSFFFWLPFYLSNNFHWKES 249
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 362 LSADLSTLFDVGGILGAIAAGYLSDVSGMSATVCTGMLFVASPILLMYQQYGAlSMTISIVLLIVVGIFVNGPYALITTS 441
Cdd:cd17342 250 EADQLSIWYDVGGIIGGIVAGYISDRMGSRSPVVVVMLLLAIPSLFVYSHSPS-DKVLNAFVMTITGFFIGGPANLISSA 328
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 665402485 442 VSAELGQHSSLEGNANALATVTAIIDGTGSIGAAVGPLLAGLI-STAGWQYVFHMLIAADIIAMVLLGRLV 511
Cdd:cd17342 329 ISADLGRQPQLRGSSEALATVTGIIDGTGSIGAAIGQVLVPLIqNRLGWMWVFYFFIIMTILTIVCILPLL 399
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
50-511 |
2.83e-77 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 247.19 E-value: 2.83e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 50 VFVLTFLAYACYHMCRKPISVVKSVLQGncstalaasgqdcgyapfDVPDATTLFGMLDSAFLFSYAIAMFASGFVAERV 129
Cdd:cd17312 4 IFLGVFLGYAAYYVCRKNFSVAKPPIVE------------------EIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRS 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 130 SLRYFLSMGMILTGVFTYMFGIArtsniHSLWYFIIVQIFAGIFQTTGWPGVVALVGRWFGKSKRGLIFGIWNSHTSIGN 209
Cdd:cd17312 66 NIRRFMSAGLLLSALANIFMGFS-----TSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGG 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 210 ILGTLIAAHYVES-DWALSFVVPGIIIAAVGFLLFLFLVDQPeivgcypqagqherrvanesdveqddeeqvrhndaein 288
Cdd:cd17312 141 ILAPILAASLASYyGWRAAFLVPGIVGLVVAIILFFFLRDSP-------------------------------------- 182
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 289 yrsaptertpilprsqpeavprgrgrpislidalfiPGVVEFSLCLFFTKLVSYTFMYWLPLYIQKSSTLGPELSADLST 368
Cdd:cd17312 183 ------------------------------------PYVWVLSLAYAFVYIVRYACLDWGPLYLYEVKGYSLIDAGWFSS 226
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 369 LFDVGGILGAIAAGYLSDVSGMSATVCTGMLFVASPILLM--YQQYGAlSMTISIVLLIVVGIFVNGPYALITTSVSAEL 446
Cdd:cd17312 227 LYEVGGIAGTILAGLLSDKLFGGRRAPIAVIYMLLMTLSLalFWFFPH-NKLLSIVLLFLIGFFVGGPINLIGGAAAQDI 305
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 665402485 447 GQHsslegnaNALATVTAIIDGTGSIGAAVGPLLAGLISTA-GWQYVFHMLIAADIIAMVLLGRLV 511
Cdd:cd17312 306 GRK-------EAAGTATGFVGLFGYLGASLAGLPLGYIIDHyGWSTVFYFLISAALLSVLLLLSLW 364
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
105-489 |
6.38e-39 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 145.98 E-value: 6.38e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 105 GMLDSAFLFSYAIAMFASGFVAERVSLRYFLSMGMILTGVFTYMFGIArtsniHSLWYFIIVQIFAGIFQTTGWPGVVAL 184
Cdd:TIGR00881 33 GLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFS-----TSLWVMAALWALNGIFQGMGWPPCGRT 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 185 VGRWFGKSKRGLIFGIWNSHTSIGNILGTLIAAHYVES--DWALSFVVPGIIIAAVGFLLFLFLVDQPEIVGcypqagqh 262
Cdd:TIGR00881 108 VTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAElySWHWVFIVPGIIAIIVSLICFLLLRDSPQSCG-------- 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 263 errvanesdveQDDEEQVRHNDAEINYRSAPTERTPilprsqpeavprgrgRPISLIDALFIPGVVEFSLCLFFTKLVSY 342
Cdd:TIGR00881 180 -----------LPPAEEMPNEEPDGDAEKKEEELTK---------------KQIFLQYVLLNKVLWYISLGYVFVYVVRT 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 343 TFMYWLPLYIQKSSTLGPELSADLSTLFDVGGILGAIAAGYLSDVSGMSATVCTGMLFVASPI--LLMYQQYGALSMTIS 420
Cdd:TIGR00881 234 GILDWSPLYLTQEKGFSKEKASWAFTLYELGGLVGTLLAGWLSDKLFNGRRGPLAVFFMALIIvsLLVYWLNPAANPLMD 313
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 421 IVLLIVVGIFVNGPYALIttsvsaelGQHSSLEGNANALATVTAIIDGTGSIGAAVGPL-LAGLISTAGW 489
Cdd:TIGR00881 314 LICLFALGFLVYGPQMLI--------GVIASELAPKKAAGTAAGFVGFFAYLGGILAGLpLGYLADGFGW 375
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
47-507 |
2.86e-37 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 142.00 E-value: 2.86e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 47 KMSVFVLTFLAYACYHMCRKPISVVKSVLQgncstalaasgQDCGYApfdvpdaTTLFGMLDSAFLFSYAIAMFASGFVA 126
Cdd:cd17345 1 RWQVFLGIFIGYAGYYLVRNNFSLAQPYLI-----------EQYGLS-------KTEIGLIGSALSIAYGLSKFVMGNLS 62
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 127 ERVSLRYFLSMGMILTGVFTYMFGIArTSNIHSLWYFIIVQIFAGIFQTTGWPGVVALVGRWFGKSKRGLIFGIWN-SHT 205
Cdd:cd17345 63 DRSNPKRFLAIGLILSAIINILIGFV-PSATSSVGLMFILLFLNGWFQGMGWPPSGRTMVHWFSKKERGTWTSIWNiSHN 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 206 SIGNILGTLI---AAHYVESDWALSFVVPGIIIAAVGFLLFLFLVDQPEIVGCYPqagqherrvanesdVEQDDEEQVRH 282
Cdd:cd17345 142 VGGGLVGPLAglgLAIFGDGWWRGAFIFPAIIAIIVAVIVLFLGKDTPESEGLPP--------------IEEYKGDYPEE 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 283 NDAEINYRSAPTertpilprsqpeavprgrgRPISLIDALFIPGVVEFSLCLFFTKLVSYTFMYWLPLYIQKSSTLGPEL 362
Cdd:cd17345 208 ADGEEEEQELSA-------------------WEIFVKYVLKNKLLWYIAIANVFVYLVRYGILDWAPTYLSEVKGFSKAQ 268
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 363 SADLSTLFDVGGILGAIAAGYLSD--VSGMSATVCTGMLFVASPILLMYQQygALSMTISIVLLIVVGIFVNGPYALItt 440
Cdd:cd17345 269 AMWAFSLFEWAAIPGTLLAGWLSDklFKGRRAPTGIIFMILVIVALIVYWL--APNVLVDLIALIALGFLIYGPVMLI-- 344
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 441 SVSAelgqhssLEGNANALATVTAIIDGTGS--IGAAVGPLLAGLISTA-GWQYVFHMLIAADIIAMVLL 507
Cdd:cd17345 345 GLQA-------LELVPKKAAGTAAGLTGLFGylGGSVLATALIGIIVDHfGWNGGFIVLLASCILAIIFL 407
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
46-513 |
2.04e-36 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 138.85 E-value: 2.04e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 46 YKMSVFVLTFLAYACYHMCRKPISVVKSVLQgncstalaasgqdcgyAPFDVPDATtlFGMLDSAFLFSYAIAMFASGFV 125
Cdd:COG2271 7 YRWRILALLFLAYFLNYLDRSNLSVAAPPLQ----------------ADLGLSAAQ--LGLLASAFFLGYALGQIPAGLL 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 126 AERVSLRYFLSMGMILTGVFTYMFGIArtsniHSLWYFIIVQIFAGIFQTTGWPGVVALVGRWFGKSKRGLIFGIWNSHT 205
Cdd:COG2271 69 ADRFGRRRVLAIGLLLWGLATLLFGFA-----TSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGG 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 206 SIGNILGTLIAAHYVES-DWALSFVVPGIIIAAVGFLLFLFLvdqpeivgcypqagqherrvanesdveqddeeqvrhnd 284
Cdd:COG2271 144 PLGGALAPPLLGWLLAAfGWRAAFLILGLPGLLLALLRFWLL-------------------------------------- 185
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 285 aeinyrsaptertpilprsqpeavprgrgrpislidalfipgvvefSLCLFFTKLVSYTFMYWLPLYIQKSSTLGPELSA 364
Cdd:COG2271 186 ----------------------------------------------ALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAG 219
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 365 DLSTLFDVGGILGAIAAGYLSD--VSGMSATVCTGMLFVASPILLMYQqygALSMTISIVLLIVVGIFVNGPYALITTSV 442
Cdd:COG2271 220 LLLSLPFLAGIVGSLLGGWLSDrlGRRRKLVLAIGLLLAALALLLLAL---LPSPALAIALLFLAGFGLGGAFGLLWALA 296
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 665402485 443 SAELGQHsslegnanALATVTAIIDGTGSIGAAVGPLLAG-LISTAGWQYVFHMLIAADIIAMVLLGRLVFK 513
Cdd:COG2271 297 AELFPKK--------ARGTASGLVNTFGFLGGALGPLLVGyLLDATGYQAAFLLLAALALLAALLALLLLRE 360
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
101-510 |
7.29e-26 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 108.81 E-value: 7.29e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 101 TTLFGMLDSAFLFSYAIAMFASGFVAERVSLRYFLSMGMILTGVFTYMFGIArtsniHSLWYFIIVQIFAGIFQTTGWPG 180
Cdd:cd17319 37 PTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFA-----TSLTSLYVLRFLLGVAEAGFFPG 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 181 VVALVGRWFGKSKRGLIFGIWNSHTSIGNILGTLIAAHYVES-DWALSFVVPGIIIAAVGFLLFLFLvdqpeivgcypqa 259
Cdd:cd17319 112 AIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLfGWRWAFIIEGLLGLLLAVLWWFYL------------- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 260 gqherrvanesdveqddeeqvrhndaeinyrsaptertpilprsqpeavprgrgrpislidalfiPGVVEFSLCLFFTKL 339
Cdd:cd17319 179 -----------------------------------------------------------------RQVWGLALGYFGINY 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 340 VSYTFMYWLPLYIQKSSTLGPELSADLSTLFDVGGILGAIAAGYLSD--VSGMSATVCTGMLFVASPILLMyqQYGALSM 417
Cdd:cd17319 194 ALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDrlLRGARRLVIIIGLLLAAVGLLL--AYLTTSP 271
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 418 TISIVLLIVVGIFVNGPYALITTSVSAELGqhsslegnANALATVTAIIDGTGSIGAAVGPLLAGLI--STAGWQYVFHM 495
Cdd:cd17319 272 VVAVILLSLAGFGIGAASPVFWSLPADLLP--------GEAAATAGGLINSGGNLGGFVAPLLIGYLvdATGSYTAAFLF 343
|
410
....*....|....*
gi 665402485 496 LIAADIIAMVLLGRL 510
Cdd:cd17319 344 LAAVALLAALLVLLL 358
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
104-507 |
1.38e-25 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 108.43 E-value: 1.38e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 104 FGMLDSAFLFSYAIAMFASGFVAERVSLRYFLSMGMILTGVFTYMFGIArtsniHSLWYFIIVQIFAGIFQTTGWPGVVA 183
Cdd:COG2223 42 LGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALA-----VSYWLLLLLGLLLGIGGGGSFAVGIA 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 184 LVGRWFGKSKRGLIFGIWNSHTSIGNILGTLIAAHYVES-DWALSFVVPGIIIAAVGFLLFLFLVDQPEivgcypqagqh 262
Cdd:COG2223 117 LVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAfGWRNAFLILGILLLVVAVLAWLFLRDPPA----------- 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 263 errvanesdveqddeeqvrhndaeinyrsaptertpilprsqpEAVPRGRGRPISLIDALFIPGVVEFSLCLFFTKLVSY 342
Cdd:COG2223 186 -------------------------------------------GAAAAAKASLRDQLEALRDPRFWLLSLLYFGTFGSFI 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 343 TFMYWLPLYIQKSSTLGPELSADLSTLFDVGGILGAIAAGYLSD-VSGMSATVCTGMLFVASPILLMYQQygaLSMTISI 421
Cdd:COG2223 223 GFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDrIGGRRVLLIVFALMALGLLLLALAL---GSLWLFL 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 422 VLLIVVGIFVNGPYALITTSVSAELGQHsslegnanALATVTAIIDGTGSIGAAVGPLLAGLI--STAGWQYVFHMLIAA 499
Cdd:COG2223 300 VLFLLLGLALGGGNGAVFALVPDIFPTK--------NAGAVYGLVGAAGGLGGFLGPLLFGALldATGSYTAAFLVFAVL 371
|
....*...
gi 665402485 500 DIIAMVLL 507
Cdd:COG2223 372 ALVALVLT 379
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
47-507 |
5.13e-25 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 107.04 E-value: 5.13e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 47 KMSVFVLTFLAYACYHMCRKPIS-VVKSVLQGncstalaasgqdcgyAPFDVPDAttlfGMLDSAFLFSYAIAMFASGFV 125
Cdd:cd17343 1 QLTIFASMFVGYTLYYFNRKSFSfVLPSLMNE---------------LGLDKSDL----GLITSSQSLAYAISKFIGGVL 61
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 126 AERVSLRYFLSMGMILTGVFTYMFGiarTSNihSLWYFIIVQIFAGIFQTTGWPGVVALVGRWFGKSKrgliFGIW---- 201
Cdd:cd17343 62 SDQISARWLFSSGLVLSGLTTVAFS---GSS--SVWVFSILWFLNGLAQGLGWPPCAKILRKWFSPSQ----FGTWwsvl 132
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 202 ----NSHTSIGNILGTLIAAHYvesDWALSFVVPGIIIAAVGFLLFLFLVDQPEIVGcypqagqherrvanesdVEQDDE 277
Cdd:cd17343 133 stsmNLAGSLGPILATLLALSY---GWRSTLSISGTVAVVMSVVCLLFIKNEPSDVG-----------------LNNIEE 192
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 278 EQvrhndaeinyrsaptertpilprSQPEAVPRGRGRpISLIDALFIPGVVEFSLCLFFTKLVSYTFMYWLPLYIQKSST 357
Cdd:cd17343 193 EE-----------------------SKGKKKKSPRGE-STLKELLLSPFLWLLSLGYLVVFGVKTAVTDWGQLFLIQDKG 248
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 358 LGPELSADLSTLFDVGGILGAIAAGYLSD------------------VSGMSATVCTGMLFvaspiLLMYQQYGALSMTI 419
Cdd:cd17343 249 QSALTGSSFMSSLEVGGFVGSIAAGYLSDwavakhgsssrgnprmplALVFMAGLTVSLHL-----FRVHITSDSSELFI 323
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 420 SIVLLIvVGIFVNGPYALIttSVSAELGQHSSLEGNANALAtvtaiidgtgSIGAAVGPLLAGL-----ISTAGWQYVFH 494
Cdd:cd17343 324 LLLGFL-IGFSLYGPIAIF--GVIANESAPSHLCGTSHAIV----------ALAANVGGVLAGLpfsyiAKHYDWRTAFL 390
|
490
....*....|...
gi 665402485 495 MLIAADIIAMVLL 507
Cdd:cd17343 391 LLEILCAITVVIL 403
|
|
| PRK11663 |
PRK11663 |
glucose-6-phosphate receptor/MFS transporter UhpC; |
105-507 |
7.64e-24 |
|
glucose-6-phosphate receptor/MFS transporter UhpC;
Pssm-ID: 183266 [Multi-domain] Cd Length: 434 Bit Score: 104.02 E-value: 7.64e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 105 GMLDSAFLFSYAIAMFASGFVAERVSLRYFLSMGMILTGVFTYMFGIARtsnihSLWYFIIVQIFAGIFQTTGWPGVVAL 184
Cdd:PRK11663 61 GLLATLFYITYGVSKFVSGIVSDRSNARYFMGIGLIATGIINILFGFSS-----SLWAFALLWVLNAFFQGWGWPVCAKL 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 185 VGRWFGKSKRGLIFGIWNSHTSIGNILGTL----IAAHYvesDWALSFVVPGIIIAAVGFLLFLFLVDQPEIVGcYPQAG 260
Cdd:PRK11663 136 LTAWYSRTERGGWWAIWNTAHNVGGALIPLvvgaIALHY---GWRYGMMIAGIIAIVVGLFLCWRLRDKPQAMG-LPSVG 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 261 QHERrvaNESDVEQDDEeqvrhnDAEINYRSaptertpILPRSqpeavprgrgrpislidALFIPGVVEFSLCLFFTKLV 340
Cdd:PRK11663 212 EWRH---DALELAQQQE------GAGLSRKE-------ILTKY-----------------VLLNPYIWLLSFSYVLVYVV 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 341 SYTFMYWLPLYIqkSSTLGPEL-SADLS-TLFDVGGILGAIAAGYLSD--VSG----MSATVCTGMLFVASPILLMyqqy 412
Cdd:PRK11663 259 RAAINDWGNLYM--SETLGVDLvTANSAvSMFELGGFIGALVAGWGSDklFNGnrgpMNLIFAAGILLSVGSLWLM---- 332
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 413 GALSMTISIVLLIVVGIFVNGPYALIttSVSAELGQHSSLEGNAnalatvTAIIDGTGSIGAAV-GPLLAGLISTAGWQY 491
Cdd:PRK11663 333 PFASYVMQAACFFTIGFFVFGPQMLI--GMAAAECSHKEAAGAA------TGFVGLFAYLGAALsGYPLAKVLEIWHWTG 404
|
410
....*....|....*..
gi 665402485 492 VFHML-IAADIIAMVLL 507
Cdd:PRK11663 405 FFVVIsIAAGISALLLL 421
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
102-478 |
2.73e-22 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 98.26 E-value: 2.73e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 102 TLFGMLDSAFLFSYAIAMFASGFVAERVSLRYFLSMGMILTGVFTYMFGIArtsniHSLWYFIIVQIFAGIFQTTGWPGV 181
Cdd:pfam07690 32 TEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFA-----SSLWLLLVLRVLQGLGAGALFPAA 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 182 VALVGRWFGKSKRGLIFGIWNSHTSIGNILGTLIAAHYVES-DWALSFVVPGiIIAAVGFLLFLFLVDQPEivgcypqag 260
Cdd:pfam07690 107 LALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLfGWRAAFLILA-ILSLLAAVLLLLPRPPPE--------- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 261 qherrvanesdveqddeeqvrhndaeinyrsaptertpilpRSQPEAVPRGRGRPISLIDALFIPGVVEFSLCLFFTKLV 340
Cdd:pfam07690 177 -----------------------------------------SKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFA 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 341 SYTFMYWLPLYIQKSStLGPELSADLSTLFDVGGILGAIAAGYLSDVSGMSATVCTGMLFVASPILLMYQQYGALSMTIS 420
Cdd:pfam07690 216 FFGLLTYLPLYQEVLG-LSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWL 294
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 665402485 421 IVLLIVVGIFVNGPYALITTSVSAELGQHsslegnanALATVTAIIDGTGSIGAAVGP 478
Cdd:pfam07690 295 LLALLLLGFGFGLVFPALNALVSDLAPKE--------ERGTASGLYNTAGSLGGALGP 344
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
96-507 |
9.97e-21 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 94.03 E-value: 9.97e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 96 DVPDATTLFGMLDSAFLFSYAIAMFASGFVAERVSLRYFLSMGMILTGVFTYMFGIArtsniHSLWYFIIVQIFAGIFQT 175
Cdd:cd06174 25 SFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFA-----PSFWLLLLGRFLLGLGSG 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 176 TGWPGVVALVGRWFGKSKRGLIFGIWNSHTSIGNILGTLIA---AHYVESDWALSFVVPGIIIAAVGFLLFLFLVDQPEi 252
Cdd:cd06174 100 LIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGgilASSLGFGWRAVFLIAAALALLAAILLLLVVPDPPE- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 253 vgcypqagqherrvanesdveqddeeqvrhndaeinyrsaptertpilPRSQPEAVPRGRGRPISLIDALFIPGVVEFSL 332
Cdd:cd06174 179 ------------------------------------------------SARAKNEEASSKSVLKLLKRVLKNPGLWLLLL 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 333 CLFFTKLVSYTFMYWLPLYIQKSSTLGPELSADLSTLFDVGGILGAIAAGYLSDVSGMSATVCTGMLFVASPILLMYqqY 412
Cdd:cd06174 211 AIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALL--L 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 413 GALSMTISIVLLIVVGIFVNGPYALITTSVsaelgqhsSLEGNANALATVTAIIDGTGSIGAAVGPLLAGLIS--TAGWQ 490
Cdd:cd06174 289 LAPSLLLLLLLLLLLGFGLGGLLPLSFALI--------AELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLaaTFGLT 360
|
410
....*....|....*..
gi 665402485 491 YVFHMLIAADIIAMVLL 507
Cdd:cd06174 361 GAFLVLAVLLLLAAILL 377
|
|
| MFS_UhpC |
cd17488 |
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ... |
41-507 |
1.50e-20 |
|
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341041 [Multi-domain] Cd Length: 364 Bit Score: 93.24 E-value: 1.50e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 41 RRDLLYKMsvfvltFLAYACYHMCRKPISVVKSVLQGNCStalaasgqdcgyapFDVPDattlFGMLDSAFLFSYAIAMF 120
Cdd:cd17488 1 RIHILASM------FIGYAVFYLTRKSFNAAMPAMLADLG--------------LDKSD----IGILGSLFYITYGVSKF 56
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 121 ASGFVAERVSLRYFLSMGMILTGVFTYMFGIARtsnihSLWYFIIVQIFAGIFQTTGWPGVVALVGRWFGKSKRGLIFGI 200
Cdd:cd17488 57 VSGLMSDRSNPRYFMGIGLIATGIINILFGFSS-----SLWAFAVLWTLNAFFQGWGWPPCARLLTHWYSRNERGFWWSI 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 201 WNSHTSIGNILGTLI---AAHYveSDWALSFVVPGIIIAAVGFLLFLFLVDQPeivgcypqagqherrvanesdveqdde 277
Cdd:cd17488 132 WNTSHNIGGALIPILtgfAALT--YGWRAGMYVPGIIAILMGIVLCWRLRDRP--------------------------- 182
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 278 eqvrhndaeinyrsaptertpilprsqpeavprgrgrpislidalfiPGVVEFSLCLFFTKLVSYTFMYWLPLYIqkSST 357
Cdd:cd17488 183 -----------------------------------------------PYIWLLAFCYVLVYVVRTAINDWGNLYL--SET 213
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 358 LGPEL-SADLS-TLFDVGGILGAIAAGYLSDVSGMSATVCTGMLF-------VASPILLMYQQYgalsmTISIVLLIVVG 428
Cdd:cd17488 214 HGYSLvKANSAvSLFEVGGLIGALVAGWGSDKLFKGNRGPMNLIFalgllvsVGALWLVPVHSY-----WLLATCFFTIG 288
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 429 IFVNGPYALITTSvSAELGqHSSLEGNAnalatvtaiidgTGSIG--AAVGPLLAG-----LISTAGWQYVFHMLIAADI 501
Cdd:cd17488 289 FFVFGPQMLIGMA-AAECS-HKDAAGSA------------TGFVGlfAYLGAALAGyplakVIESWGWSGFFIVISIAAA 354
|
....*.
gi 665402485 502 IAMVLL 507
Cdd:cd17488 355 ISGLLL 360
|
|
| uhpT |
PRK09556 |
hexose-6-phosphate:phosphate antiporter; |
101-523 |
2.47e-20 |
|
hexose-6-phosphate:phosphate antiporter;
Pssm-ID: 236564 [Multi-domain] Cd Length: 467 Bit Score: 93.57 E-value: 2.47e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 101 TTLFGMLDSAFLFSYAIAMFASGFVAERVSLRYFLSMGMILTGVFTYMFGIARTSNIHSLWYFIIVQIFAGIFQTTGWPG 180
Cdd:PRK09556 63 TTELGMIGLGFSITYGVGKTLVGYYADGKNTKQFLPFLLILSAICMLGFGASLGSGSVSLGLMIALWALSGFFQSTGGPC 142
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 181 VVALVGRWFGKSKRGLIFGIWNSHTSIGNILGTLIA---AHYV-ESDWALSFVVPGIIIAAVGFLLFLFLVDQPEIVGCy 256
Cdd:PRK09556 143 SYSTITRWTPRRKRGRFLGFWNISHNLGGAGAGGVAlwgANYFfDGHVIGMFIFPSIIALIIGFIGLRYGSDSPEELGW- 221
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 257 pqaGQHERRVANESDVEQDDEEQVRHNDAEINYRsaptertpilprsqpeavprgrgrpislidaLFIPGVVEFSLCL-- 334
Cdd:PRK09556 222 ---GKAEEIFGEPISEEDKETESTDMTKWQIFVE-------------------------------YVLKNPVIWLLCFan 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 335 FFTKLVSYTFMYWLPLYIQKSSTLGPELSADLSTLFDVGGILGAIAAGYLSDVS----GMSATVCTGMLFVAspiLLMYQ 410
Cdd:PRK09556 268 IFLYIVRIGIDNWSPVYAFQELGFSKEDAINTFTLFEIGALVGSLLWGWLSDLAngrrALVACIALALIIFT---LGVYQ 344
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 411 QygALSMTISIVLLIVVGIFVNGPYALITTSV------------SAELGQHSSLEGNANALATVTAIIDGTGSIGAAVGP 478
Cdd:PRK09556 345 H--ATSEYMYLASLFALGFLVFGPQLLIGVAAvgfvpkkaigvaNGIKGTFAYLFGDSFAKVGLGMIADPTKNGTPIFGY 422
|
410 420 430 440
....*....|....*....|....*....|....*....|....*
gi 665402485 479 LLaglistAGWQYVFHMLIAADIIAMVLLGRLVFKEFAALRRASH 523
Cdd:PRK09556 423 TL------TGWAGTFAALDIAAIGCICLMAIVAVMEERKIRREKK 461
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
105-511 |
1.37e-19 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 90.33 E-value: 1.37e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 105 GMLDSAFLFSYAIAMFASGFVAERVSLRYFLSMGMILTGVFTYMFGIArtsniHSLWYFIIVQIFAGIFQTTGWPGVVAL 184
Cdd:cd17325 34 GLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFA-----TSYWQLLLARFLQGLASAAVWPAAMAL 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 185 VGRWFGKSKRGLIFGIWNSHTSIGNI----LGTLIAAHYvesDWALSFVVPGIIIAAVGFLLFLFLvdqpeivgcypqag 260
Cdd:cd17325 109 IADIAPPEERGRAMGIFSSAIGLGFLigplLGGLLADAL---GYRAPFLVCAALALLALVLALLLL-------------- 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 261 qherrvanesdveqddeeqvrhndaeinyrsaptertPILPRSQPEAVPRGRGRPISLIDALFIPGVVEFSLCLFFTKLV 340
Cdd:cd17325 172 -------------------------------------PEPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFA 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 341 SYTFMYWLPLYIQKSSTLGPELSADLSTLFDVGGILGAIAAGYLSDVSGMSATVCTGMLFVASPILLMYQqygALSMTIS 420
Cdd:cd17325 215 FGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPL---ATSFWLL 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 421 IVLLIVVGIFvngpYALITTSVSAELgqhsSLEGNANALATVTAIIDGTGSIGAAVGPLLAGLIS-TAGWQYVFHMLIAA 499
Cdd:cd17325 292 LLLLALLGLG----LGLVFPATLALL----ADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYdAFGFATPFLAAAAL 363
|
410
....*....|..
gi 665402485 500 DIIAMVLLGRLV 511
Cdd:cd17325 364 LLLAAVLFLLLR 375
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
101-476 |
5.24e-19 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 88.49 E-value: 5.24e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 101 TTLFGMLDSAFLFSYAIAMFASGFVAERVSLRYFLSMGMILTGVFTYMFGIArtsniHSLWYFIIVQIFAGIFQTTGWPG 180
Cdd:COG2814 44 PAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALA-----PSLWLLLAARFLQGLGAGALFPA 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 181 VVALVGRWFGKSKRGLIFGIWNSHTSIGNILGTLIAAHYVES-DWALSFVVPGIIIAAVGFLLFLFlvdqpeivgcypqa 259
Cdd:COG2814 119 ALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLfGWRWVFLVNAVLALLALLLLLRL-------------- 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 260 gqherrvanesdveqddeeqvrhndaeinyrsaptertpiLPRSQPEAVPRGRGrpiSLIDALFIPGVVEFSLCLFFTKL 339
Cdd:COG2814 185 ----------------------------------------LPESRPAARARLRG---SLRELLRRPRLLLLLLLAFLLGF 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 340 VSYTFMYWLPLYIQKSSTLGPELSADLSTLFDVGGILGAIAAGYLSDVSGMSATVCTGMLFVASPILLMYQqygALSMTI 419
Cdd:COG2814 222 GFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLAL---AGSLWL 298
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 665402485 420 SIVLLIVVGIFVNGPYALITTSVSAELGQHsslegnanALATVTAIIDGTGSIGAAV 476
Cdd:COG2814 299 LLLALFLLGFGFGLLFPLLQALVAELAPPE--------ARGRASGLYNSAFFLGGPL 347
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
104-482 |
5.10e-18 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 86.26 E-value: 5.10e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 104 FGMLDSAFLFSYAIAMFASGFVAERVSLRYFLSMGMILTGVFTYMFGIARtsnihSLWYFIIVQIFAGIFQTTGWPGVVA 183
Cdd:TIGR00895 54 LGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALAT-----NVTQLLILRFLAGLGLGGLMPNLNA 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 184 LVGRWFGKSKRGLIFGIWNSHTSIGNILGTLIAAHYVES-DWALSFVVPGIIIAAVGFLLFLFLvdqPEivgcyPQAGQH 262
Cdd:TIGR00895 129 LVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVfGWRSLFYVGGIAPLLLLLLLMRFL---PE-----SIDFLV 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 263 ERRvanesdveqDDEEQVRHNDAEINYRSAPTERTPILPRSQPEAVprgrgrpiSLIDALFIP----GVVEFSLCLFFTK 338
Cdd:TIGR00895 201 SKR---------PETVRRIVNAIAPQMQAEAQSALPEQKSTQGTKR--------SVFKALFQGktarITVLLWLLYFMLL 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 339 LVSYTFMYWLPlYIQKSSTLGPELSADLSTLFDVGGILGAIAAGYLSDVSGmSATVCTGMLFVASPILLMYQQYGalSMT 418
Cdd:TIGR00895 264 VGVYFLTNWLP-KLMVELGFSLSLAATGGALFNFGGVIGSIIFGWLADRLG-PRVTALLLLLGAVFAVLVGSTLF--SPT 339
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 665402485 419 ISIVLLIVVGIFVNGPYalitTSVSAELGQHSSLEGNANALATVTAIidgtGSIGAAVGPLLAG 482
Cdd:TIGR00895 340 LLLLLGAIAGFFVNGGQ----SGLYALMALFYPTAIRATGVGWAIGI----GRLGAIIGPILAG 395
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
102-510 |
8.74e-16 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 79.15 E-value: 8.74e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 102 TLFGMLDSAFLFSYAIAMFASGFVAERVSLRYFLSMGMILTGVFTYMFGIArtsniHSLWYFIIVQIFAGIFQTTGWPGV 181
Cdd:COG2807 53 TQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLA-----PSVALLLAGTALIGAGIAVGNVLL 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 182 VALVGRWFGKsKRGLIFGIWNSHTSIGNILGTLIAAHYVES-DWALSFVVPGIIIAAVGFLLFLFLVDQPeivgcypqag 260
Cdd:COG2807 128 PGLIKRWFPD-RVGLMTGLYTAAMGLGAALAAGLTVPLAAAlGWRGALAVWALLALLALLLWLPLLRRRP---------- 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 261 qherrvanesdveqddeeqvrhndaeinyrsaptertpilpRSQPEAVPRGRGRPIslidaLFIPGVVEFSLCLFFTKLV 340
Cdd:COG2807 197 -----------------------------------------AAAAAAPAAASLRSL-----WRSPLAWLLTLFFGLQSLL 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 341 SYTFMYWLPLYIQkSSTLGPELSADLSTLFDVGGILGAIAAGYLSDVSGMSATVCTGM--LFVASPILLMYqqygaLSMT 418
Cdd:COG2807 231 YYAVVAWLPPILR-DAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLglLGLAGLLGLLL-----APGS 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 419 ISIVLLIVVGIFVNGPYALITTSVSAELGqhsslegNANALATVTAIIDGTGSIGAAVGPLLAGLI--STAGWQYVFHML 496
Cdd:COG2807 305 LPWLWAVLLGLGQGGLFPLALTLIGLRAR-------TPAEAAALSGMAQSVGYLLAALGPLLVGALhdATGSWTAALLLL 377
|
410
....*....|....
gi 665402485 497 IAADIIAMVLLGRL 510
Cdd:COG2807 378 AALAVLMLVAGLLA 391
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
105-513 |
2.02e-14 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 74.89 E-value: 2.02e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 105 GMLDSAFLFSYAIAMFASGFVAERVSLRYFLSMGMILTGVFTYMFGIArtsniHSLWYFIIVQIFAGIFQTTGWPGVVAL 184
Cdd:COG0738 46 GLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALA-----PSYPLLLLALFLLGLGLGLLDVAANPY 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 185 VGRWFGKSKRGLI--FGIWNShtsIGNILGTLIAAHYVESDWALSFVVPGIIIAAVGFLLFLFLVdqpeivgcypqagqh 262
Cdd:COG0738 121 VAALGPETAASRLnlLHAFFS---LGALLGPLLGGLLILLGLSLSWHLPYLILAVLLLLLALLFL--------------- 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 263 errvanesdveqddeeqvrhndaeinyrsapteRTPiLPRSQPEAVPRGrGRPISLIDALFIPGVVEFSLCLFFTKLVSY 342
Cdd:COG0738 183 ---------------------------------RSK-LPEIEEEEEEAA-GSAASLKSLLKNPRLLLGGLAIFLYVGAEG 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 343 TFMYWLPLYIQKSSTLGPELSADLSTLFDVGGILGAIAAGYLSDVSGMSATVCTGMLFVASPILLMYQqygALSMTISIV 422
Cdd:COG0738 228 AIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALL---APGPWLALI 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 423 LLIVVGIFVNGPYALITTSVSAELGQHSslegnanalATVTAIIDGTGSIGAAVGPLLAGLIS-TAGWQYVFHMLIAAdI 501
Cdd:COG0738 305 GLALVGLGLSLMFPTIFSLALDGLGKRT---------AAAVSAVLIMGIVGGAIGPPLIGFLAdAFGLRAAFLVPLVC-Y 374
|
410
....*....|..
gi 665402485 502 IAMVLLGRLVFK 513
Cdd:COG0738 375 LLILLLALALKR 386
|
|
| glpT |
PRK11273 |
glycerol-3-phosphate transporter; |
50-507 |
2.10e-14 |
|
glycerol-3-phosphate transporter;
Pssm-ID: 236889 [Multi-domain] Cd Length: 452 Bit Score: 75.52 E-value: 2.10e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 50 VFVLTFLAYACYHMCRKPISVVKSVL--QGncstalaASGQDCGYAPfdvpdattlfgmldSAFLFSYAIAMFASGFVAE 127
Cdd:PRK11273 30 IFLGIFFGYAAYYLVRKNFALAMPYLveQG-------FSRGDLGFAL--------------SGISIAYGFSKFIMGSVSD 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 128 RVSLRYFLSMGMILTGVFTYMFGIA--RTSNIHSLwyFIIVQIfAGIFQTTGWPGVVALVGRWFGKSKRGLIFGIWN-SH 204
Cdd:PRK11273 89 RSNPRVFLPAGLILAAAVMLFMGFVpwATSSIAVM--FVLLFL-CGWFQGMGWPPCGRTMVHWWSQKERGGIVSVWNcAH 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 205 TSIGNILGTL-IAAHYVESDWALSFVVPGIIIAAVGFLLFLFLVDQPEIVGCYPqagQHERRVANESDVEQDDEEQVRHN 283
Cdd:PRK11273 166 NVGGGLPPLLfLLGMAWFNDWHAALYMPAFAAILVALFAFAMMRDTPQSCGLPP---IEEYKNDYPDDYNEKHEQELTAK 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 284 DAEINYrsaptertpILPRsqpeavprgrgrpiSLIDALFIPGVvefslclfFTKLVSYTFMYWLPLYIQKSSTLGPELS 363
Cdd:PRK11273 243 QIFMQY---------VLPN--------------KLLWYIAIANV--------FVYLLRYGILDWSPTYLKEVKHFALDKS 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 364 ADLSTLFDVGGILGAIAAGYLSDVSGMSATVCTGMLFVASPIL--LMYQQYGALSMTISIVLLIVVGIFVNGPYALItts 441
Cdd:PRK11273 292 SWAYFLYEYAGIPGTLLCGWMSDKVFRGNRGATGVFFMTLVTIatIVYWLNPAGNPTVDMACMIVIGFLIYGPVMLI--- 368
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 665402485 442 vsaelGQHSSLEGNANALATVTAIIDGTGSIGAAVGP--LLAGLISTAGWQYVFHMLIAADIIAMVLL 507
Cdd:PRK11273 369 -----GLHALELAPKKAAGTAAGFTGLFGYLGGSVAAsaIVGYTVDFFGWDGGFMVMIGGSILAVILL 431
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
105-507 |
9.79e-14 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 72.66 E-value: 9.79e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 105 GMLDSAFLFSYAIAMFASGFVAERVSLRYFLSMGMILTGVFtyMFGIARTsniHSLWYFIIVQIFAGIFQTTGWPGVVAL 184
Cdd:cd17475 34 GLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAA--ALLMALV---GSYPVLLVLLFLVGAGYGSVQPGGGRA 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 185 VGRWFGKSKRGLIFGIWNSHTSIGNILGTL----IAAHYvesDWALSFVVPGIIIAAVGFLLFLFLVDQPEIvgcypqag 260
Cdd:cd17475 109 IMRWFPPRERGLAMGIRQTGVPLGGALAAAllppLALHY---GWRAAFVVAGLVSILAAVLFWLFYREPPAA-------- 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 261 qherrvanesdveqddeeqvrhndaeinyrSAPTERTPILPRSQPEAVprgRGRPISLIdalfipGVVEFSLCLFFTKLV 340
Cdd:cd17475 178 ------------------------------SAATESASTLLRSLKEVL---RNRDVWLI------AIAGALLVAPQFALL 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 341 SYtfmywLPLYIQKSSTLGPELSADLSTLFDVGGILGAIAAGYLSD-------VSGMSATVCTGMLFVASPILLMYQQYG 413
Cdd:cd17475 219 TF-----LLLFLHDHLGLSVVAAGALLAVAQLGGALGRIGLGRVSDrvfggrrRPVLVITAAIAAAALLVLSLLSPGTPL 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 414 ALSMTISIVLlivvGIFVNGPYALITTSVSAELGQHSSleGNANALATVTAiidgtgSIGAAVGPLLAGLI--STAGWQY 491
Cdd:cd17475 294 WLLVLLLILL----GLFAIGWNGLYLTLVAESAGPEQA--GTALGLANTIN------FIGIAIGPPLFGLLvdATHSYAP 361
|
410
....*....|....*.
gi 665402485 492 VFHMLIAADIIAMVLL 507
Cdd:cd17475 362 AWLALALLLVLAALLL 377
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
101-485 |
2.40e-12 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 68.80 E-value: 2.40e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 101 TTLFGMLDSAFLFSYAIAMFASGFVAERVSLRYFLSMGMILTGVFTymfgiARTSNIHSLWYFIIVQIFAGIFQTTGWPG 180
Cdd:cd17328 33 DSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAAT-----LLSSFAPNFWQLLLFRALVGIGEASYSPI 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 181 VVALVGRWFGKSKRGLIFGIWNSHTSIGNILG----TLIAAHYVesDWALSFVVPGIIIAAVGFLLFLFLVDQpeivgcy 256
Cdd:cd17328 108 APTIIADLFPKEKRTRALGVFYFAIPLGSGLGyvvgGLVAQATG--GWRWAFRVTGVLGVLLAILLLLFVREP------- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 257 pqagqherrvanesdveqddeeqvrhndaeinyrsaptertpilPRSQPEAVPRGRGRPISLIDALFI----PGVVEFSL 332
Cdd:cd17328 179 --------------------------------------------PRGAAEGGVMAKSTATSFLADLKAlaknPSFILSTL 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 333 CLFFTKLVSYTFMYWLPLYIQKSSTLGPELSADLSTLFD----VGGILGAIAAGYLSDVSGMS-----ATVCTGMLFVAS 403
Cdd:cd17328 215 GFTAVSFVTGALAFWAPTFFLRAFGVGDLSSADVGLIFGaitcIAGVLGVLLGGILADRLRRKtpradPLVCAVGLLAAA 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 404 PILLMYQQYGALSMTISIVLLIVVGIFVNGPYALITTSVSAELgqHSSLEGNANALATVTaiidgTGSIGAAVGPLLAGL 483
Cdd:cd17328 295 PFLFLALVLALSNLLLAWVLLFLGEFLLSLNWAPVFAILLYVV--IPTRRSTASAIQILL-----SHLLGDAGSPYLIGL 367
|
..
gi 665402485 484 IS 485
Cdd:cd17328 368 IS 369
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
95-506 |
7.26e-12 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 66.80 E-value: 7.26e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 95 FDVPDATTlfGMLDSAFLFSYAIAMFASGFVAERVSLRYFLSMGMILTGVFTYMFGIArtsniHSLWYFIIVQIFAGIFQ 174
Cdd:cd17324 29 FGVSVAQA--GLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALA-----PSFALLLLARALAGLAH 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 175 TTGWPGVVALVGRWFGKSKRGLIFGIWNSHTSIGNILG----TLIAAHYvesDWALSFVVPGIIIAAVGFLLFLFLVDQP 250
Cdd:cd17324 102 GGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGrplgGLLGQLL---GWRAAFLAIAVLALLAALLLWRLLPSLP 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 251 eivgcypqagqherrvanesdveqddeeqvrhndaeinyrsAPTERTPILPRSQPEAVPRGRGRPISLIdalfipgvvef 330
Cdd:cd17324 179 -----------------------------------------PKKPGSLGLLSSLLLLLRNPRLRLAYLI----------- 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 331 SLCLFFTKLVSYTFMywlPLYIQKSSTLGPELSADLSTLFDVGGILGAIAAGYLSDVSGMSATVCTGMLFVASPILLMyq 410
Cdd:cd17324 207 TFLLFGGFFALYTYL---APFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLT-- 281
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 411 qYGALSMTISIVLLIVVGIFVNGPYALITTSVSAELGQHSSLegnANALATVTAiidgtgSIGAAVGPLLAGL-ISTAGW 489
Cdd:cd17324 282 -LLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEARGL---ASSLYLAAY------NLGGALGAALGGLvLDHGGW 351
|
410
....*....|....*..
gi 665402485 490 QYVFHMLIAADIIAMVL 506
Cdd:cd17324 352 AGVGWVGAALLLLALLL 368
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
105-510 |
1.04e-10 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 63.36 E-value: 1.04e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 105 GMLDSAFLFSYAIAMFASGFVAERVSLRYFLSMGMILTGVFTYMFGIArtsniHSLWYFIIVQIFAGIFQTTGWPGVVAL 184
Cdd:cd17474 37 GLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLS-----DSFALLLAGRALQGIGAAGLGPLALTL 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 185 VGRWFGKSKRGLIFGIWNSHTSIGNILGTLIAAHYVESDWALSFVVPGIIIaAVGFLLFLFLVDQPeivgcypqagqher 264
Cdd:cd17474 112 IGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAAISWRYPFFLLAALI-PVAFLAILFLLPEP-------------- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 265 rvanesdveqddeeqvrhndaeinyrSAPTERTPILPRSQPEAVPRGRGRPISLIDALFipgvveFSLCLFftklvsyTF 344
Cdd:cd17474 177 --------------------------KEKAKSSSATKLRDLKKALRGRGLLTFLVSAFL------YFFLYF-------AF 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 345 MYWLPLYIQKSSTLGPELSADLSTLFDVGGILGAIAAGYLSDV-SGMSATVCTGM-LFVASPILLMYqqygALSMTISIV 422
Cdd:cd17474 218 LTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKrFGARRILVIGLlLYALSLLLLGF----VPSLALLLI 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 423 LLIVVGIFVNGPYALITTSVSAELGQHSslegnanaLATVTAIIDGTGSIGAAVGPLLAGLI-STAGWQYVFHMLIAADI 501
Cdd:cd17474 294 AIVLFGLGLGLNLPLLTTLVTELAPEEE--------RGTASSLYNFVRFLGQAVGPLLFGLLlEIFGLSAPFLVGAAIAL 365
|
....*....
gi 665402485 502 IAMVLLGRL 510
Cdd:cd17474 366 AAAVLLALL 374
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
109-251 |
1.68e-10 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 63.04 E-value: 1.68e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 109 SAFLFSYAIAMFASGFVAERVSLRYFLSMGMILTGVFTYMfgiarTSNIHSLWYFIIVQIFAGIFQTTGWPGVVALVGRW 188
Cdd:cd17327 48 TVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLLTLL-----TAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMW 122
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 189 FGKSKRGLIFGIWNSHTSIGNILGTLIAAHYVESD-------WALSFVVPGIIIAAVGFLLFLFLVDQPE 251
Cdd:cd17327 123 YKREEQAKRIAFFYAAAGLGSIFGGLLAYGVFKILgvgglagWRWLFIIEGLITIIIGLVIFFWLPDNPS 192
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
52-516 |
5.17e-10 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 61.48 E-value: 5.17e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 52 VLTFLAYACYHMCRKPISV-VKSVLQGNCSTALAASGQDCGYAPFDVPD---ATTLFGMLDSAFLFSYAIAMFASGFVAE 127
Cdd:cd17318 2 ILLFLGFAVVYAMRVNLSVaIVAMVNSTATHDNNNTSTDKDTLPVEAPEfdwSEKTQGIILSSFFYGYILTQIPGGYLAE 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 128 RVSLRYFLSMGMILTGVFTYMFGIArtSNIHSLWYfIIVQIFAGIFQTTGWPGVVALVGRWFGKSKRGLIFGIWNSHTSI 207
Cdd:cd17318 82 KYGAKRVLGYSILITALLTLLTPLA--ARGGYGAL-IVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTSIAYSGSQF 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 208 GNILGTLIAAHYVES-DWALSFVVPGiIIAAVGFLLFLFLVdqpeivgcypqagqherrvanesdveqddeeqvrhndae 286
Cdd:cd17318 159 GTVIAMPLSGFLCESlGWPSIFYIFG-GLGLLWCLLWFFLV--------------------------------------- 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 287 inyrsaptertpilprsqpeavprgrgRPI-SLIDALFipgvvefslCLFFTklvSYTFMYWLPLYIqkSSTLGPELSAD 365
Cdd:cd17318 199 ---------------------------LPVwAIVVAHF---------GHNWG---FYTLLTELPTYM--SDVLHFNIKSN 237
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 366 --LSTLFDVGGILGAIAAGYLSDV----SGMSAT----VCTGMLFVASPILLMYQQYGALSMTISIVLLIVVGIFVNGPY 435
Cdd:cd17318 238 gfLSSLPYLAMWICSIVGGYLADWlrsrGILSTTtvrkLFTSIGFLGPGVFLIALGYLGSNATLAVVFLTLSVGLSGACY 317
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 436 ALITTSVsaelgqhssLEGNANALATVTAIIDGTGSIGAAVGPLLAGLI-----STAGWQYVFhmLIAAdiiAMVLLGRL 510
Cdd:cd17318 318 SGFLVNH---------LDLAPNYAGTLMGITNTAATIAGIISPLIVGAIvkndqTIGQWRIVF--FISA---AIYILGAI 383
|
....*.
gi 665402485 511 VFKEFA 516
Cdd:cd17318 384 FYLIFG 389
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
105-484 |
7.88e-10 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 60.80 E-value: 7.88e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 105 GMLDSAFLFSYAIAMFASGFVAERVSLRYFL--SMGMILTGVFTYMFGiartsnihSLWYFIIVQIF-----AGIFQTTG 177
Cdd:cd17333 34 SVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLilGLLLISLALALIFAT--------PSIYLFVVLMFlaglgAGILDTGA 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 178 WPGVVALvgrwfGKSKRGLIFGIWNSHTSIGNILGTLIAAHYVesDWALSFVVPGIIIAAVGFLLFLFLVDqpeivgcyp 257
Cdd:cd17333 106 NTFVGAL-----FEESSATRLNVLHGFFGLGALIGPLIATSLL--TSELSWSWAYLIIGLIYLLLAILILL--------- 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 258 qagqherrvanesdVEQDDEEQVRHNDAEINYRSAPTertpilprsqpeavprgrgrpislIDALFIPGVVEFSLCLFFT 337
Cdd:cd17333 170 --------------TLFPELPSARNPQQSVGAFSASA------------------------SRLLRNPSIILGALALFLY 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 338 KLVSYTFMYWLPLYIQKSSTLGPELSADLSTLFDVGGILGAIAAGYLSDVSGMSATVctgMLFVASPILLMYQQYGALSM 417
Cdd:cd17333 212 VGAETAFSSWVPSYLVEKKHVSDGLAGYLLSGFWVGITIGRLLGGPISRRIKPHTLL---VLSGSGALLGLLILLLAPTL 288
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 665402485 418 TISIVLLIVVGIFVNGPYALITTSVSAELGQHSSlegnanalaTVTAIIDGTGSIGAAVGPLLAGLI 484
Cdd:cd17333 289 VVGLVATALLGLFMAALFPTILSLGISNLPYAKG---------KGTSVLLAAGSIGGAIIPFIMGFI 346
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
105-507 |
6.69e-09 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 57.70 E-value: 6.69e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 105 GMLDSAFLFSYAIAMFASGFVAERVSLRYFLSMGMILTGVFTYMFGIARtsnihSLWYFIIVQIFAGIFQTTGWPGVVAL 184
Cdd:cd17371 37 GLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQ-----NYWQLLILRALAGLGFGGEWAAGAAL 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 185 VGRWFGKSKRGLIFGIWNSHTSIGNILGTLIAA-----HYVESDWALSFVVpGIIIAAVGFLLFLFLVDQPEIvgcypQA 259
Cdd:cd17371 112 MAEYVPARHRGKALGYVQSGWAVGWLLATLLAAllfplLPPEIAWRVLFLL-GALPALLVLFIRRFVKEPPQW-----QA 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 260 GQHERRVAnesdveqddeeqvrhndaeinyrsaptertpiLPRSQPEAVPRGRGRPISLIDALFipgvvefSLCLFFTkl 339
Cdd:cd17371 186 ARAARRHF--------------------------------ADRPSLRELFSPPLLRTTLLASLL-------ATGALGG-- 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 340 vSYTFMYWLPLYIQKSSTLGPELSADLSTLFDVGGILGAIAAGYLSDVSGMSATVCTGMLFVASPILLMYQqyGALSMTI 419
Cdd:cd17371 225 -YYGITTWLPSYLTGERGLSFEGSAGYLVVTILGGFLGYLAGGFLADRIGRRNNFALFALGSAISILLYFF--LPLSPTL 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 420 SIVLLIVVGIFVNGPYALITTSVSaELGQhsslegnANALATVTAIIDGTGSIGAAVGPLLAGLISTAG-WQYVFHMLIA 498
Cdd:cd17371 302 ILILGFPLGFFASGPFSGMGAYLT-ELFP-------TAVRATAQGFCYNVGRIIGALFPFLVGFLATSGsLGTAIAVFAA 373
|
....*....
gi 665402485 499 ADIIAMVLL 507
Cdd:cd17371 374 VYYIAGLVL 382
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
105-247 |
8.03e-09 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 57.56 E-value: 8.03e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 105 GMLDSAFLFSYAIAMFASGFVAERVSLRYFLSMGMILTGVFTYMFGIARTSNIHSLwyfIIVQIFAGIFQTTGWPGVVAL 184
Cdd:cd17380 37 GLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLTPLLAYSSLPLL---ILSRILLGLGEGVHFPSMTSL 113
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 665402485 185 VGRWFGKSKRGLIFGIWNSHTSIGNILGTLIAAHYVE-SDWALSFVVPGIIiaavGFLLFLFLV 247
Cdd:cd17380 114 FSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEyYGWPSVFYFFGLL----GLLWALVWL 173
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
318-510 |
9.74e-09 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 57.21 E-value: 9.74e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 318 LIDALFIPGVVEFSLCLFFTKLVSYTFMYWLPlYIQKSSTLGPELSADLSTLFDVGGILGAIAAGYLSDVSGMSATVCTG 397
Cdd:cd17365 164 LILLPLLRGTLLLWVTFFMGLLLVYLLNSWLP-KLMVEAGYSLSQALTITLLLNIGGVIGSLLLGWLADRFGPKRVLALF 242
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 398 MLFVAspILLMYQQYGALSMTISIVLLIVVGIFVNGPYALITTsVSAELGQhsslegnANALATVTAIIDGTGSIGAAVG 477
Cdd:cd17365 243 FALGA--VSLALLGVSPASLVLLYVLVFLAGACVNGAQVGLYA-LAARFYP-------TEVRATGVGWALGVGRLGAILG 312
|
170 180 190
....*....|....*....|....*....|....*...
gi 665402485 478 PLLAGLISTAGWQY--VFHML---IAADIIAMVLLGRL 510
Cdd:cd17365 313 PLLGGLLLAAGLGPesVFLALaipAALGALAVLLLRLR 350
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
105-507 |
2.78e-08 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 55.64 E-value: 2.78e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 105 GMLDSAFLFSYAIAMFASGFVAERVSLRYFLSMGMILTGVFTYMFGIArtsniHSLWYFIIVQIFAGIFQTTGWPGVVAL 184
Cdd:cd17478 34 GLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFA-----PNYWLLLLLVALAGIGSAAFHPEGARL 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 185 VGRwFGKSKRGLIFGIWNSHTSIGNILGTLIAAHYVESDWALSFVVPGIIIAAVGFLLFLFLvdqpeivgcypqagqher 264
Cdd:cd17478 109 ASQ-AAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRL------------------ 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 265 rvanesdveqddeeqvrhndaeinYRSAPTERTPILPRSQPEAVPRGRGRPISLIDALFipgvveFSLCLFFTKLVSYtf 344
Cdd:cd17478 170 ------------------------RPLKKPEAKKAAAKSSARSTLKGVWRALLLLLIIV------FLRSWVLSSLTTF-- 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 345 mywLPLYIqKSSTLGPELSADLSTLFDVGGILGAIAAGYLSDVSGMSATVCTGMLFVASPILLMYQQYGalsmTISIVLL 424
Cdd:cd17478 218 ---LPFYL-VQRGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPG----IWSYILL 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 425 IVVGIFVNGPYALITTSVSAELGQHSSLegnANALatVTAIIDGTGSIGAAVgplLAGLISTAGWQYVFHMLIAADIIAM 504
Cdd:cd17478 290 VLAGFLLFASFPVTVVLAQELLPGNVGL---ASGL--MMGLSFGLGGIGAPV---LGALADAFGLESVLLILALLPLLGA 361
|
...
gi 665402485 505 VLL 507
Cdd:cd17478 362 LLA 364
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
315-488 |
6.62e-08 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 54.49 E-value: 6.62e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 315 PISLIDALFIPGVVEFSLCLFFTKLVSYTFMYWLPLYIQKSSTLGPELSADLSTLFDVGGILGAIAAGYLSDVSGMSATV 394
Cdd:cd17321 158 PIGLVALLLARTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVL 237
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 395 CTGMLFVASPILLMYQQYGALSMTISIVLLIVVGIFVNGPYALITTSVSAELGQHSSlegnanalATVTAIIDGTGSIGA 474
Cdd:cd17321 238 VAGLLLTAVGLLLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKA--------GAASGILNTARQLGG 309
|
170
....*....|....
gi 665402485 475 AVGPLLAGLISTAG 488
Cdd:cd17321 310 ALGVALLGALLTAG 323
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
116-484 |
6.98e-08 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 54.91 E-value: 6.98e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 116 AIAMFASGFVAERVSLRY-----FLSMGMILTGVFTYMFGIART-SNIHSLWYFIIVQIFAGIFQTTGWPGVVALVGRWF 189
Cdd:COG2211 60 AITDPLIGALSDRTRTRWgrrrpWILIGAIPLALSFVLLFTAPDlSPTGKLIYALVTYLLLGLAYTLVNIPYSALGAELT 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 190 GKSK-RGLIFGIWNSHTSIGNILGTLIAA---HYVESDWALSFVVPGIIIAAVGFLLFLFLVdqpeivgcypqAGQHERR 265
Cdd:COG2211 140 PDYEeRTRLSSWRFAFAGLGGLLASVLPPplvAAFGGDAALGYRLTALIFAVLGLLAFLLTF-----------FGTKERP 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 266 VANEsdveqddeeqvrhndaeinyrsaptERTPILPrsqpeavprgrgrpiSLIDALFIPGVVEFSLCLFFTKLVSYTFM 345
Cdd:COG2211 209 VPEE-------------------------EKVSLKE---------------SLKALLKNRPFLLLLLAYLLFFLALALVA 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 346 YWLPLYIQKSSTLGPELSADLSTLFDVGGILGAIAAGYLSDVSGMSATVCTGMLFVASPILLMYqQYGALSMTISIVLLI 425
Cdd:COG2211 249 ALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLF-FLGPGNLWLLLVLAA 327
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 665402485 426 VVGIFVnGPYALITTSVSAELGQHSSLEGNANALATVTAIIDGTGSIGAAVGPLLAGLI 484
Cdd:COG2211 328 LAGIGL-GAILVLPWAMLADVVDYDEWKTGRRREGLYFGIFTFAIKLGQALAGALAGLL 385
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
330-507 |
8.85e-08 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 53.96 E-value: 8.85e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 330 FSLCLFFTKLVSYTFMYWLPLYIQKSSTLGPELSADLSTLFDVGGILGAIAAGYLSDVSGMSATVCTGMLFVASPILLMY 409
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 410 QqygALSMTISIVLLIVVGIFVNGPYALITTSVSAELGqhsslegnANALATVTAIIDGTGSIGAAVGPLLAGLISTA-G 488
Cdd:pfam07690 81 F---ASSLWLLLVLRVLQGLGAGALFPAALALIADWFP--------PEERGRALGLVSAGFGLGAALGPLLGGLLASLfG 149
|
170
....*....|....*....
gi 665402485 489 WQYVFHMLIAADIIAMVLL 507
Cdd:pfam07690 150 WRAAFLILAILSLLAAVLL 168
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
99-248 |
1.08e-07 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 54.14 E-value: 1.08e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 99 DATTLFGMLDSAFLFSYAIAMFASGFVAERVSLRYFLSMGMILTGVFTYMFGIARTSNihsLWYFIIVQIFAGIFQTTGW 178
Cdd:COG2211 261 LSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGN---LWLLLVLAALAGIGLGAIL 337
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 179 PGVVALV------GRW-FGKSKRGLIFGIWNSHTSIGNILGTLIA----------------AHYVESDWALSFVVPGIII 235
Cdd:COG2211 338 VLPWAMLadvvdyDEWkTGRRREGLYFGIFTFAIKLGQALAGALAglllalfgyvagaaqsPSALTGIRLLFFLLPAVLL 417
|
170
....*....|...
gi 665402485 236 AAVGFLLFLFLVD 248
Cdd:COG2211 418 LLAALLLLFYPLT 430
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
316-507 |
1.47e-07 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 53.37 E-value: 1.47e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 316 ISLIDALFIPGVVEFSLCLFFTKLVSYTFMYWLPLYIQKSSTLGPELSADLSTLFDVGGILGAIAAGYLSDVSGMSATVC 395
Cdd:cd17316 168 PALLALLLRRRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLV 247
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 396 TGML--FVASPILLMYQQYGALSMTISIVLLIVVGIFVNGPYALITTSVSAelgqhsslegnANALATVTAIIDGTGSIG 473
Cdd:cd17316 248 IGLIlsGILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFP-----------TEVRATGVGLSYNLGRLG 316
|
170 180 190
....*....|....*....|....*....|....*.
gi 665402485 474 AAVGPLLAG--LISTAGWQYVFHMLIAADIIAMVLL 507
Cdd:cd17316 317 GGGAPPLIAllLASTGGTGVPALILALLAIVALIVA 352
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
101-246 |
2.14e-07 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 52.51 E-value: 2.14e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 101 TTLFGMLDSAFLFSYAIAMFASGFVAERVSLRYFLSMGMILTGVFTYMFGIArtsniHSLWYFIIVQIFAGIFQTTGWPG 180
Cdd:COG0477 48 SAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLA-----PSPELLIAARALQGIGAGGLMPG 122
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 665402485 181 VVALVGRWFGKSKRGLIFGIWNSHTSIGNILGTLIAAHYVES-DWALSFVVpGIIIAAVGFLLFLFL 246
Cdd:COG0477 123 ALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAAlGWRWIFLI-NAPLGLLALVLRLRL 188
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
116-507 |
3.83e-07 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 52.25 E-value: 3.83e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 116 AIAMFASGFVAERVSLRYFLSMGMILTGVFTYMFGIArtsnIHSLWYFIIVQIFAGIFQTTGWPGVVaLVGRWFGKSKRG 195
Cdd:cd17341 48 ALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLALALA----VSSYWGLLVLGFLLGFAGANFASGQP-WASFWFPKEKIG 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 196 ----LIFGIWNSHTSIGNILGTLIAAHYVESD----WALSFVVPGIIIAAVGFLLFLFLVDQPEIvgcypqagqherrva 267
Cdd:cd17341 123 gaagGIAGAGNMGVAVSQLLAPLIAGAIVFDGgfvgWRNAFFVPGILLAIAAVLVLLFGDDLPTG--------------- 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 268 nesdveqddeeqvrhndaeinyrsaptertpilPRSQPEAVPRgrgrpisLIDALFIPGVVEFSLCLFFTKLVSYTFMYW 347
Cdd:cd17341 188 ---------------------------------KASALEFLKV-------QLAVLKNYRTWILSLLYGVTFGSFVGFSNV 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 348 LPLYIQKSSTLGPELSADLSTLFDVGGILGAIAAGYLSDVSGMSATvcTGMLFV----ASPILLMYQQYGALSMTISIVL 423
Cdd:cd17341 228 LPTYFKTRFGLPLVTAGILAALFPLAGALARPAGGWLSDRFGGRRR--LWWLFIvmtiGAALLSLSLPTSGTNLVLFLAL 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 424 LIVVGIFVNGPYALITTSVSAELGqhsslegnaNALATVTAIIDGTGSIGAAVGPLLAGLISTAGWQYVFH-MLIAADII 502
Cdd:cd17341 306 FVALGLGAGAGNGSVFRMVPFIFR---------RELGAVTGLVGAIGGLGGFFLPLLFGSSALMTGSGVGAfSLFGVLAV 376
|
....*
gi 665402485 503 AMVLL 507
Cdd:cd17341 377 ACTLL 381
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
109-510 |
1.19e-06 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 50.73 E-value: 1.19e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 109 SAFLFSYAIAMFASGFVA-------ERVSLRYFLSMGMILTGVftymfGIARTSNIHSLWYFIIVQIFAGIFQ--TTGWP 179
Cdd:cd17355 38 AVISLAFTVGLLAFGLAQpfvgrllDRFGPRRVMLLGLLLLAA-----GLVLLALATSLWQLYLLWGLLGGGGagTLAAV 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 180 GVVALVGRWFGKsKRGLIFGIWNSHTSIGNILGTLIAAHYVES-DWALSFVVPGIIIAAVGFLLFLFLVDQPeivgcypq 258
Cdd:cd17355 113 AFATVAAWWFER-RRGLALGILTAGGGLGSLVFLPLGAALIEAfGWRTALLVLALLALLVLVPVLLLLRRRP-------- 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 259 agqherrvanesdveqddeeqvrhndAEINYRSAPTERTPILPRSQPEAVPRGRGRPISLIdalfipgvveFSLCLFFTk 338
Cdd:cd17355 184 --------------------------ADLALRAYDDASPASPGSTLKEALRSASFWLLALA----------FFLCGFAV- 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 339 lvsYTFMYWLPLYIQkSSTLGPELSADLSTLFDVGGILGAIAAGYLSDVSGMSATVCTGM-LFVASPILLMYQQYGALSM 417
Cdd:cd17355 227 ---VGLIVHLVPYLA-DRGISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYaLRALGLALLLLLPFPPLAL 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 418 tisIVLLIVVGIFVNGPYALITTSVSAELGQHSslegnanaLATVTAIIDGTGSIGAAVGPLLAGLISTAGWQY--VFHM 495
Cdd:cd17355 303 ---LLFAALFGLGWGATVPLTAALAARYFGARS--------YGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYtaAWAL 371
|
410
....*....|....*
gi 665402485 496 LIAADIIAMVLLGRL 510
Cdd:cd17355 372 AVALGLIAALLVLPI 386
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
300-488 |
1.32e-06 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 50.73 E-value: 1.32e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 300 LPRS-QPEAVPRGRGRPISLIDALFIPGVVEFSLCL----FFTKLVSYTFMYWLPLYIqKSSTLGPELSADLSTLFDVGG 374
Cdd:PRK11551 190 LPESrAFAQAAGAGKQRAPVLRALFGEGRATATLLLwisyFFTLIVLYFLLNWLPSLL-VGQGLSRSQAGLVQIAFNIGG 268
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 375 ILGAIAAGYLSDVSGMSATVctgmLFVASPILLmyqQYGALSMTISIVLLIVV----GIFVNGP----YALITTSVSAEL 446
Cdd:PRK11551 269 ALGSLLIGALMDRLRPRRVV----LLIYAGILA---SLAALAAAPSFAGMLLAgfaaGLFVVGGqsvlYALAPLFYPTQV 341
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 665402485 447 gqhsslegNANALATVTAIidgtGSIGAAVGPLLAGLISTAG 488
Cdd:PRK11551 342 --------RGTGVGAAVAV----GRLGSMAGPLLAGQLLALG 371
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
109-251 |
3.47e-06 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 49.15 E-value: 3.47e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 109 SAFLFSYAIAMFASGFVAERVSLRYFLSMGMILTGvftymFGIARTSNIHSLWYFIIVQ-IFAGIFQTTGWPGVVALVGR 187
Cdd:cd17353 45 TLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFG-----LGFILSAFAISLPLLFLGYgVLGGIGAGIGYITPVSTAVK 119
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 665402485 188 WFgKSKRGLIFGIWNSHTSIGNILGTLIAAHYVE-SDWALSFVVPGIIIAAVGFLLFLFLVDQPE 251
Cdd:cd17353 120 WF-PDKRGLATGIVIAGFGLGSLIFSPLIAYLINtVGVPTTFLILGIIFLIIIVIGAFLIRDPPK 183
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
103-502 |
1.08e-05 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 47.82 E-value: 1.08e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 103 LFGMLDSAFLFSYAIAMFASGFVAERVSLRYFLSMGMILTGVFTYMFGIARTSNIhslwyfiIVQIFAGIFQTTGWPGVV 182
Cdd:TIGR00894 77 LQGLILSSHFYGQIIIQIPVGYLAGKYVFKWSIGIGMFLSSVISIVIPWAAGGGI-------ALVVFCRVIQGLAQGSVS 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 183 ----ALVGRWFGKSKRGLIFGIWNSHTSIGNILGTLIAAHYVESD--WALSFVVPGIIIAAVGFLLFLFLVDQPEIvgcY 256
Cdd:TIGR00894 150 pathKIIVKWAPPKERSRLLGMSTSGFQLGTFIFLPISGWLCESWggWPMIFYVFGIVGCAWSLLWFVFPADDPSI---H 226
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 257 PQAGQHERRVANESDVEQDdeeqvrhndaEINYRSAPTertpilprsqpeavprgRGRPISLidalfipGVVEFSLCLFF 336
Cdd:TIGR00894 227 PCISKFEKKYINSSLQGQK----------GSTRQSLPI-----------------KAIPKSL-------PVWAIWFAIFG 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 337 TKLVSYTFMYWLPLYIQKSSTLGPELSADLSTLFDVGGILGAIAAGYLSDVSGMSAT--------VCTGMLFVASPILLM 408
Cdd:TIGR00894 273 HFWLYTILPTYLPTFISWVLRVSGKENGLLSSLPYLFAWLCSIFAGYLADFLKSSKTlsltaarkIFNGIGGLGPGIFAY 352
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 409 YQQYGALSMTISIVLLIVVGIFVNGPYALITTsvsaelgqhSSLEGNANALATVTAIIDGTGSIGAAVGPLLAGLISTAG 488
Cdd:TIGR00894 353 ALPYLSAAFYLTIIILTLANAVSSGPLAGVLI---------NSLDLAPRFLGFIKGITGLPGFIGGLIASTLAGNILSQD 423
|
410
....*....|....*...
gi 665402485 489 ----WQYVFHMLIAADII 502
Cdd:TIGR00894 424 sknvWLIVFLIMAFVNIL 441
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
101-246 |
1.71e-05 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 47.19 E-value: 1.71e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 101 TTLFGMLDSAFLFSYAIAMFASGFVAERVSLRYFLSMGMILTGV-FTYMfgiartSNIHSLWYFIIVQIFAGIFQTTGWP 179
Cdd:cd17335 232 KTLIGLLWTVGVVSEIPFFFFSSRLIQRFGHVGLLYLGLLAYVVrWLLY------SFLENPWLVLPIELLHGLTFALVWA 305
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 665402485 180 GVVALVGRWFGKSKRGLIFGIWNS-HTSIGNILGTLIAAHYVES-DWALSFVVPGiIIAAVGFLLFLFL 246
Cdd:cd17335 306 AAVSYASAAAPPGLRATAQGLLQGlYFGLGGGLGSLIGGYLYEAfGARTTFRFFA-IAALAGLLAFFLI 373
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
315-506 |
2.70e-05 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 46.40 E-value: 2.70e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 315 PISLIDALFIPGVVEFSLCLFFTKLVSYTFMYWLPLYIQKSSTLGPELSADLSTLFDVGGILGAIAAGYL-SDVSGMSAT 393
Cdd:cd17502 157 PIGGLALALLRTILLSSIFGFLFGGALFGLIYYLPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALiSKTGRYKPL 236
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 394 VCTGMLFVASPILLMYQQYGALSMTISIVLLIVVGIFVNGPYALITTSVSAELGQHSslegnanaLATVTAIIDGTGSIG 473
Cdd:cd17502 237 IVIGTILMSVGAGLLTTLTLDTSKWLLIGYLILLGLGLGIGFQQPLVAVQNAVPPAD--------VGVATATNTFFRSLG 308
|
170 180 190
....*....|....*....|....*....|...
gi 665402485 474 AAVGpllaglistAGWQYVFHMLIAADIIAMVL 506
Cdd:cd17502 309 GTLG---------VAITDVFLVALALAALAFLL 332
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
102-245 |
2.91e-05 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 46.45 E-value: 2.91e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 102 TLFGMLDSAFLFSYAIAMFASGFVAERVSLRYFLSMGMILTGVFTYMFGIArtsniHSLWYFIIVQIFAGIFQTTGWPGV 181
Cdd:cd06173 244 AGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLS-----PSLWLLLAALFLLGLAGGLFNVPL 318
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 665402485 182 VALVGRWFGKSKRGLIFGIWNSHTSIGNILGTLIAAHYVES-DWALSFVVPGIIIAAVGFLLFLF 245
Cdd:cd06173 319 NTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADAlGLSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
330-511 |
4.39e-05 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 45.64 E-value: 4.39e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 330 FSLCLFFTKLVSYTFMYWLPLYIQKSStLGPELSADLSTLFDVGGILGAIAAGYLSDVSGMSATVCTGMLFVASPILLMy 409
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLG-ASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLF- 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 410 qqygalSMTISIVLLIVVGIFVNGPYALITTSVSAELGQHSSLEGNANALATVTAIIdgtgSIGAAVGPLLAGLISTA-G 488
Cdd:cd17325 79 ------AFATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAI----GLGFLIGPLLGGLLADAlG 148
|
170 180
....*....|....*....|...
gi 665402485 489 WQYVFHMLIAADIIAMVLLGRLV 511
Cdd:cd17325 149 YRAPFLVCAALALLALVLALLLL 171
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
330-511 |
5.16e-05 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 45.35 E-value: 5.16e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 330 FSLCLFFTKLVSYTFMYWLPLyIQKSSTLGPELSADLSTLFDVGGILGAIAAGYLSDVSGMSATVCTGMLFVASPILLMY 409
Cdd:COG2814 15 LALGAFLSGLGIGIVLPALPL-IAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCA 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 410 QqygALSMTISIVLLIVVGIFVNGPYALITTSVSAELGqhsslegnANALATVTAIIDGTGSIGAAVGPLLAGLISTA-G 488
Cdd:COG2814 94 L---APSLWLLLAARFLQGLGAGALFPAALALIADLVP--------PERRGRALGLLGAGLGLGPALGPLLGGLLADLfG 162
|
170 180
....*....|....*....|...
gi 665402485 489 WQYVFHMLIAADIIAMVLLGRLV 511
Cdd:COG2814 163 WRWVFLVNAVLALLALLLLLRLL 185
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
366-511 |
6.20e-05 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 45.26 E-value: 6.20e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 366 LSTLFDVGGILGAIAAGYLSDVSGMSATVCTGMLFVASPILLMYQqygALSMTISIVLLIVVGIFVNGPYALITTSVSAE 445
Cdd:COG2223 45 LFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLAL---AVSYWLLLLLGLLLGIGGGGSFAVGIALVSKW 121
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 665402485 446 LGQHSslegnanaLATVTAIIDGTGSIGAAVGPLLAG-LISTAGWQYVFHMLIAADIIAMVLLGRLV 511
Cdd:COG2223 122 FPPDR--------RGLALGLAAGGGNLGAAVAAFLAPlLIAAFGWRNAFLILGILLLVVAVLAWLFL 180
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
97-506 |
1.44e-04 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 44.10 E-value: 1.44e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 97 VPDATTLFGMLDSafLFSYAIAMFA--SGFVAERVSLRYFLSMGMILTGVFTYMFGIARtsnihSLWYFIIVQIFAGIFQ 174
Cdd:cd17473 30 VPNSELLVPLLLT--LPALFIALFAplAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLD-----SLYALLASRALLGIGV 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 175 TTGWPGVVALVGRWFGKSKRGLIFGIWNSHTSIGNILGTLIAAHYVESDWALSFVVPGI-IIAAVGFLLFLFlvdqpeiv 253
Cdd:cd17473 103 AGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAEIGWRAPFLVYLLaLPVLILVLLFLP-------- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 254 gcypqagqherrvanesdveqddeeqvrhndaeinyrsAPTERTPILPRSQPEAVPRGRGRPISLIDALfipgvvefslc 333
Cdd:cd17473 175 --------------------------------------EPARKSKSAASPGAATAAALPWKRVLPIYFL----------- 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 334 LFFTKLVSYTFMYWLPLYIQKSSTLGPELSADLSTLFDVGGILGAIAAGYLSDVSGMSATVCTGMLFVASPILLMyqqyg 413
Cdd:cd17473 206 AFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLL----- 280
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 414 alSMTISIVLLIVVGIFVNGPYALITTSVSAELGQHSSLEGNANALATVTAIIdgtgSIGAAVGPLLAGLISTAGWQYVF 493
Cdd:cd17473 281 --ALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAF----FLGQFLSPLVLGPLVNLTGGLSG 354
|
410
....*....|...
gi 665402485 494 HMLIAAdIIAMVL 506
Cdd:cd17473 355 AFLILG-VLALVL 366
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
105-506 |
1.85e-04 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 43.74 E-value: 1.85e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 105 GMLDSAFLFSYAIAMFASGFVAERVSLRYFLSMGMILTGVFTYMFGIArtsniHSLWYFIIVQIFAGIFQTTGWPGVVAL 184
Cdd:cd17489 34 GLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLA-----TSVALLLVLRLIHGIGWGAFTTAAATL 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 185 VGRWFGKSKRGLIFGIWNSHTSIGNILGTLIAAHYVEsdwALSFVVPGIIIAAVGFLLFLFLvdqpeivgcypqagqher 264
Cdd:cd17489 109 VADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQ---HLGFAVLFIVAAVLALLALLLV------------------ 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 265 rvanesdveqddeeqvrhndaeinyrsAPTERTPILPRSQPEAVPRGRGRpislidaLFIPGVVEFSLCLFFTKLVSYTF 344
Cdd:cd17489 168 ---------------------------FLVKDPPPVAAEEAEAGTRAFRR-------LVEKKVLPPALILFLASIAYGAI 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 345 MYWLPLYIQkssTLGPELSADLSTLFDVGGILGAIAAGYLSDVSGMSATVCTGMLFVASPILLmyqqygaLSMTISIVLL 424
Cdd:cd17489 214 STFLPLYAA---ERGISNAGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLL-------LSFAGSPWML 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 425 IVVGIFVNGPYALITTSVSAELGQHSSLEGNANALATVTAIIDgtgsIGAAVGPLLAGLISTA-GWQYVFHMLIAADIIA 503
Cdd:cd17489 284 LLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFD----LGIGLGGLLLGLVAELfGYRAMFLLAAVVVLLA 359
|
...
gi 665402485 504 MVL 506
Cdd:cd17489 360 LVL 362
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
95-510 |
2.71e-04 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 43.37 E-value: 2.71e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 95 FDVPDATTLFGMLDSAFLFSYAIAMFASGFVAERVSLRYFLSMGMILTGVFTYMFGIARTSNIHSLWYFIIVQIFAGIFQ 174
Cdd:cd06173 27 LQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLGSLSLWLLLVLAFLLGIAS 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 175 TTGWPGVVALVGRWFGKSKRGLIFGIWNSHTSIGNILGTLIAAHYVesdwALSFVVPGIIIAAVGFLLFLFLVdqpeivg 254
Cdd:cd06173 107 AFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLV----ALLGPGGAFAINALSFLLSALLL------- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 255 CYPQAGQHERRVANESDVEQDDEEQVRHndaeinYRSAPTERTPILprsqpeavprgrgrpislidalfipgvvefSLCL 334
Cdd:cd06173 176 LFIRRPPPAAPGESSSLLLRDLREGLRY------LRRSPLLRLLLL------------------------------ALAL 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 335 FFTKLVSYTFMywLPLYIQKSSTLGPELSADLSTLFDVGGILGAIAAGYLSDVSGMSATVCTGMLFVASPILLMYQQYGA 414
Cdd:cd06173 220 FALLGGALTVL--LPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSL 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 415 LSMTISIVLLIVVGIFVNGP-YALITTSVSAELgqhsslegnanaLATVTAIIDGTGSIGAAVGPLLAGLISTA-GWQYV 492
Cdd:cd06173 298 WLLLAALFLLGLAGGLFNVPlNTLLQLRVPDEL------------RGRVFSVYNALNSGAMPLGALLAGLLADAlGLSAV 365
|
410
....*....|....*...
gi 665402485 493 FhMLIAADIIAMVLLGRL 510
Cdd:cd06173 366 F-LLAGALLLLAALLLLL 382
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
120-247 |
3.06e-04 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 42.98 E-value: 3.06e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 120 FASGFVAERVSLRYFLSMGMILTGVFTYMFGIArtsniHSLWYFIIVQIFAGIFQTTGWPGVVALVGRWFGKSKRGLIFG 199
Cdd:cd17329 53 LIGGRLADRFGRKPVMLAGLLLRALGFALLGFA-----HSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFS 127
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 665402485 200 IWNSHTSIGNILGTLIAAHYVESDWALSFvvpgiIIAAVGFLLFLFLV 247
Cdd:cd17329 128 LLYWAINLGVAIGPLLGGLLLLYSFRLLF-----LAAAVLFLLAALVL 170
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
335-527 |
3.17e-04 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 42.98 E-value: 3.17e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 335 FFTKLVSYTFMYWLPLYIQKSSTLGPELSADLSTLFDVGGILGAIAAGYLSDVSGMSATVCTGMLFVASPILLMyqqyGA 414
Cdd:cd17329 9 FLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALL----GF 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 415 LSMTISIVLLIVVGIFVNGpyaLITTSVSAELGQHSSLEGNANALATVTAIIdgtgSIGAAVGPLLAGLISTAGWQYVFH 494
Cdd:cd17329 85 AHSPWLFAIALVLTGFGGG---LFEPASEAMIADVTTPENRTRAFSLLYWAI----NLGVAIGPLLGGLLLLYSFRLLFL 157
|
170 180 190
....*....|....*....|....*....|...
gi 665402485 495 MLIAADIIAMVLLGRLvFKEFAALRRASHRIRI 527
Cdd:cd17329 158 AAAVLFLLAALVLLFL-LPETRPKRRAAEKTEI 189
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
101-507 |
3.18e-04 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 42.93 E-value: 3.18e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 101 TTLFGMLDSAFLFSYAIAMFASGFVAERVSLRYFLSMGMILTGVFTYMFGIArtsniHSLWYFIIVQIFAGIFQTTGWPG 180
Cdd:cd17477 30 TALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALT-----DSPWVWFLLRFVMGIGLAGLFVV 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 181 VVALVGRWFGKSKRGLIFGIWNSHTSIGNILGTLIAAHYVESDWALsFVVPGIIIAAVGFLLFLFLVDQPEIvgcypqag 260
Cdd:cd17477 105 SESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGTAGALP-FLIAAVLLLLALVPLLLTRRAAPEI-------- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 261 qherrvanesdveqddeEQVRHNDAEINYRSAPTertpilprsqpeavprgrgrpisLIDALFIPGVVEFSLclfftklv 340
Cdd:cd17477 176 -----------------EEAESISLRRLLRIAPL-----------------------ALLGAFVAGFLEGAF-------- 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 341 sYTFMywlPLYIQkSSTLGPELSADLSTLFDVGGILGAIAAGYLSDVSG--MSATVCTGMLFVASPILLMYQQYGALSMt 418
Cdd:cd17477 208 -YSLL---PLYGL-RLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDrrRVLLGCALLGALAALLLPLVPGLPLALL- 281
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 419 isiVLLIVVGIFVNGPYALITTSVSAELGQHSSLEGNANALATVtaiidgtgSIGAAVGPLLAGLISTAGWQYVFHMLIA 498
Cdd:cd17477 282 ---VLLFLWGGAAGPLYTLALALAGDRLPGDELVAANAALLLLY--------GLGSVIGPLLAGALMDAFGPHGLFLFLA 350
|
....*....
gi 665402485 499 ADIIAMVLL 507
Cdd:cd17477 351 AVALLFLLF 359
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
100-245 |
3.70e-04 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 42.80 E-value: 3.70e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 100 ATTLFGMLDSAFLFSYAIAMFASGFVAERV-SLRYFLSMGMILTGVFTYMFGIARtsnihSLWYFIIVQIFAGIFQTTGW 178
Cdd:cd06174 237 SVAVAGLLLSLFGLAGALGSLLLGLLSDRLiGRKPLLLIGLLLMALGLALLLLAP-----SLLLLLLLLLLLGFGLGGLL 311
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 665402485 179 PGVVALVGRWFGKSKRGLIFGIWNSHTSIGNILGTLIAAHYVESDWALSFVVPGIIIAAVGFLLFLF 245
Cdd:cd06174 312 PLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
109-245 |
5.11e-04 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 42.20 E-value: 5.11e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 109 SAFLFSYAIAMFASGFVAERVSLRYFLSMGMILTGVFTYMFGIARTSNIhslWYFIIVQIFAGIFQTTGWPGVVALVGRW 188
Cdd:cd17316 220 LLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSGSP---TLLLLLLFILSFFVGGVWGALYAYLAEL 296
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 665402485 189 FGKSKRGLIFGIWNSHTSIGNILGTLIAAHYVESDWALSFVVPGIIIAAVGFLLFLF 245
Cdd:cd17316 297 FPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVALIVAL 353
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
109-491 |
6.89e-04 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 42.18 E-value: 6.89e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 109 SAFLFSYAIAMFASGFVAERVSLRYFLSMGMILTGVFTYMFGIArtsniHSLWYFIIVQIFAGIFQTTGWPGVVALVGRW 188
Cdd:cd17503 38 TSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLA-----PNLASLIIFRILQGFGGGVLIPLAQTILLRI 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 189 FGKSKRGLIFGIWNSHTSIGNILGTLIAAHYVES-DWALSFVVPgIIIAAVGFLLflflvdqpeivgcypqagqherrva 267
Cdd:cd17503 113 YPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNlSWRWIFYIN-LPIGILALLL------------------------- 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 268 nesdveqddeeqvrhndaeinyrsapterTPILPrsqpeavprgrgrpislIDALFIPGVVEFSLCLFFTKLVSYTFMYW 347
Cdd:cd17503 167 -----------------------------APLLD-----------------LRLFKDRNFTLGLLLSFLLGLGLFGAMFL 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 348 LPLYIQKSSTLGPELSADLSTLFDVGGILGAIAAGYLSDVSGMSATVCTGMLFVASPILLMYQQYGALSMTISIVLLIVV 427
Cdd:cd17503 201 LPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLALGTLLLAFLTPDTSLWLIILPLFIR 280
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 665402485 428 GIFVNGPYALITTSVSAELGQHSSleGNANALATVTAIIdgTGSIGAAVgplLAGLISTAGWQY 491
Cdd:cd17503 281 GLGMGLVFMPLNTLALNSLPPEQI--GDATALFNTIRQL--GGSIGTAL---LATLLTNRTQFH 337
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
111-245 |
9.26e-04 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 41.41 E-value: 9.26e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 111 FLFSYAIAMFASGFVAeRVSLRYFLSMGMILTGVFTYMFGIARTSNIHSLWYFIIVQIFAGIFQTTGWPGVVALVGRWFG 190
Cdd:cd17330 216 LALVGIAGILAQLLLI-PRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVP 294
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 665402485 191 KSKRGLIFGIWNSHTSIGNILGTLIAAHYVESDWALSFVVPGIIIAAVGFLLFLF 245
Cdd:cd17330 295 SKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAGLLLIALFLLSL 349
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
111-247 |
1.02e-03 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 41.43 E-value: 1.02e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 111 FLFSYAIAMFASGFVAERVSLRY----FLSMGMILTGVFTYMFGIArtsniHSLWYFIIVQIFAGIFQTTGWPGVVALVG 186
Cdd:cd17489 232 FFTVYAIALLLSRPFSGKLSDRKgpktVIIPGLLLLALGLLLLSFA-----GSPWMLLLAAVLYGLGFGLLFPALQALAV 306
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 665402485 187 RWFGKSKRGLIFGIWNSHTSIGNILGTLIAAHYVESdwaLSFVVP---GIIIAAVGFLLFLFLV 247
Cdd:cd17489 307 DLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAEL---FGYRAMfllAAVVVLLALVLYIFLL 367
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
105-251 |
1.20e-03 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 41.40 E-value: 1.20e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 105 GMLDSAFLFSYAIAMFASGFVAERVSLRYFLSMGMILTGVFTYMFGIArtsnIHSLWYFIIVQIFAGIFQTTGWPGVVAL 184
Cdd:COG2223 244 GLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALA----LGSLWLFLVLFLLLGLALGGGNGAVFAL 319
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 665402485 185 VGRWFGKSKRGLIFGIWNSHTSIGNILGTLIAAHYVES--DWALSFVVpGIIIAAVGFLLFLFLVDQPE 251
Cdd:COG2223 320 VPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDAtgSYTAAFLV-FAVLALVALVLTLLLYRRPR 387
|
|
| MFS_SLC17A5 |
cd17381 |
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of ... |
105-245 |
2.42e-03 |
|
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of transporters; Solute carrier family 17 member 5 (SLC17A5) is also called sialin, H(+)/nitrate cotransporter, H(+)/sialic acid cotransporter (AST), membrane glycoprotein HP59, or vesicular H(+)/aspartate-glutamate cotransporter. It transports glucuronic acid and free sialic acid out of the lysosome after its cleavage from sialoglycoconjugates, which is required for normal CNS myelination. It also mediates the membrane potential-dependent uptake of aspartate and glutamate into synaptic vesicles and synaptic-like microvesicles. In the plasma membrane, it functions as a nitrate transporter. Recessive mutations in the SLC17A5 gene cause the allelic disorders, Infantile sialic acid storage disease (ISSD) and Salla disease (a predominantly neurological disorder). SLC17A5 belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340939 [Multi-domain] Cd Length: 397 Bit Score: 40.53 E-value: 2.42e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 105 GMLDSAFLFSYAIAMFASGFVAERVSLRYFLSMGMILTGVFTYMFGIARTSNIHslwYFIIVQIFAGIFQTTGWPGVVAL 184
Cdd:cd17381 68 GWILGSFFYGYIITQIPGGYLASKIGGKLLLGFGILGTAVFTLLTPLAADLGAG---YLIAVRALEGLGEGVTFPAMHAM 144
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 665402485 185 VGRWFGKSKRGLIFGIwnshTSIGNILGTLIA-------AHYVesDWALSFVVPGiiiaAVGFLLFLF 245
Cdd:cd17381 145 WASWAPPLERSRLLTI----SYAGAQLGTVVSlplsgliCYYL--DWTYVFYIFG----AVGLLWFFL 202
|
|
| MFS_DtpA_like |
cd17346 |
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily ... |
137-245 |
2.61e-03 |
|
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily of transporters; The DtpA-like subfamily includes four Escherichia coli proteins: dipeptide and tripeptide permeases A (DtpA, TppB or YdgR), B (DtpB or YhiP), C (DtpC or YjdL), and D (DtpD or YbgH). They are proton-dependent permeases that transport di- and tripeptides. DtpA and DtpB display a preference for di- and tripeptides composed of L-amino acids. DtpC shows higher specificity for dipeptides compared to tripeptides, and prefers dipeptides containing a C-terminal lysine residue. The DtpA-like subfamily belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340904 [Multi-domain] Cd Length: 399 Bit Score: 40.25 E-value: 2.61e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 137 MGMILTG----VFTYMFGIARTSNIHSLWYFIivqiFAGIFQTTG----WPGVVALVGRWFGKSKRGLIFGIWNSHTSIG 208
Cdd:cd17346 276 LGLLLLGlsflLMVLAASFAGGSGKVSALWLV----LSYFLQTLGelclSPVGLSMITKLAPAKFAGFMMGLWFLASALG 351
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 665402485 209 NILGTLIAAHYVESDWALS--------FVVPGIIIAAVGFLLFLF 245
Cdd:cd17346 352 NILAGYLAGFYAQPKDPLAsalvytdyFGLIGVIALVAGIILLLL 396
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
109-243 |
2.70e-03 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 40.44 E-value: 2.70e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 109 SAFLFSYAIAMFASGFVAERVSLRYFLSMGMILTGVFTYMFGIArtSNIHSLWYFIIVQ-IFAGIFQttgwPGVVALVGR 187
Cdd:TIGR00711 44 TSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVA--PNLELMIIFRVIQgFGGGPLI----PLSFSTLLN 117
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 665402485 188 WFGKSKRGLIFGIWNSHTSI----GNILGTLIAAHYvesDWALSF---VVPGIIIAAVGFLLF 243
Cdd:TIGR00711 118 IYPPEKRGRAMAIWGLTVLVapalGPTLGGWIIENY---HWRWIFlinVPIGIIVVVVAFFIL 177
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
117-245 |
3.93e-03 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 39.52 E-value: 3.93e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 117 IAMFASGFVAERVSLRYFLSMGMILTGVFTYMFGIARTsnihsLWYFIIVQIFAGIFQTTGWPGVVALVGRWFGKSKRGL 196
Cdd:cd17329 251 LLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFANT-----LAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGS 325
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 665402485 197 IFGIWNSHTSIGNILGTLIAAHYVES--DWALSFVVPGIIIAAVGFLLFLF 245
Cdd:cd17329 326 YMGFYALAWGLGRAIGPLVGGLLLDLlgPGLPWLILAALGLIAAALLLGLQ 376
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
315-487 |
4.10e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 39.48 E-value: 4.10e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 315 PISLIDALFIPGVVEFSLCLFFTKLVSYTFMYWLPLYIQKSSTLGPELSADLSTL----FDVGGILGAIAAGYLSDVSGM 390
Cdd:cd17504 167 PLIDLRLLRRRNVLLANITALLAGFGMFMVFQLLPQLLQLPTPTGFGLGITEAGLlllpGALVMLIAGPLAGRLIARVGP 246
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 391 SATVCTGMLFVASPILLMYqqYGALSMTISIVLLIVVGIFVNGPYALITTSVSAELGqhsslegnANALATVTAIIDGTG 470
Cdd:cd17504 247 RRVLLIGLVISAVGLLLLA--LLHSSLWALVVALLLIGIGLGLAFASLPNIVVESVP--------PDRTGIATGMNTVLR 316
|
170
....*....|....*..
gi 665402485 471 SIGAAVGPLLAGLISTA 487
Cdd:cd17504 317 TIGSAIGPAIAGAILTT 333
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
110-507 |
4.39e-03 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 39.45 E-value: 4.39e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 110 AFLFSYAIAMFaSGFVAERVSLRY-FLSMGMILTGVFTYMFGIARTSnIHSLWYFIIVQIFAGIFQttgwPGVVALVGRW 188
Cdd:cd17370 43 AEALGSLLRLF-SGYLSDRTGKRKpLVILGYGLSALAKPLLALAGSW-QLVLLLRILERLGKGIRT----PPRDALLADA 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 189 FGKSKRGLIFGIWNSHTSIGNILGTLIAA---HYVESDWALSFVVpGIIIAAVGFLLFLFLVDQPEivgcypqagqherr 265
Cdd:cd17370 117 TPPSGRGKAFGLHRALDTLGAVLGPLLAAlllYLLGGNYRTIFLL-AAIPALLALLILLFVVKEYP-------------- 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 266 vanesdveqddeeqvrhndaeinyrsapteRTPILPRSQPEavPRGRGRPISLIDALFIPGVVEFSLclfftklVSYTFM 345
Cdd:cd17370 182 ------------------------------RPPKLRKKSKK--TSLKKLPKAFWLYLLAVALFALGN-------FSFAFL 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 346 ywlpLYIQKSSTLGPELSADLSTLFDVGGILGAIAAGYLSDVSGMSATVCTGML-FVASPILLMyqqyGALSMTISIVLL 424
Cdd:cd17370 223 ----ILRAQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLsLALAYLGFA----LGSSLWLLLLGF 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 425 IVVGIFvngpYALITTSVSAELGQHSSLEGNANALATVTAIIdgtgSIGAAVGPLLAG-LISTAGWQYVFHMLIAADIIA 503
Cdd:cd17370 295 ILWGLY----MGAQESIERAAVADLVPAELRGTAYGLFNTVV----GIGWLLASLIAGyLWDLISPSAAFLFSAVLALIA 366
|
....
gi 665402485 504 MVLL 507
Cdd:cd17370 367 LLLL 370
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
322-510 |
4.40e-03 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 39.46 E-value: 4.40e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 322 LFIPGVVEFSLCLFFTKLVSYTFMYWLPLYIqKSSTLGPELSADLSTLFDVGGILGAIAAGYLSDVSGMSAT----VCTG 397
Cdd:cd17352 180 LKDPTFVLLALGVSFAMLGFFVPFVYLPSYA-KSLGIDESDAAFLLSIIGISDIVGRILLGLLADKPRIGRLylyiFTLL 258
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 398 MLFVASPILLMYQQYGALsmtisIVLLIVVGIFVNGPYALIttsvSAELGQHSSLEGNANALATVTAIidgtGSIGAAVG 477
Cdd:cd17352 259 ILGLSLLAFPLATTYVGL-----IVFSVLFGFCSGSYSSLT----PVILADLVGLEKLSNAYGLVLLF----QGLAALVG 325
|
170 180 190
....*....|....*....|....*....|....*
gi 665402485 478 PLLAGLI--STAGWQYVFHMLIAADIIAMVLLGRL 510
Cdd:cd17352 326 PPIAGLLrdYTGDYDAAFYFCGACLLLSGVLLFLL 360
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
366-526 |
4.92e-03 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 39.47 E-value: 4.92e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 366 LSTLFDVGGILGAIAAGYLSDVSGMSATVCTGMLFVASPILLMYQQYGALSMTISIVLlIVVGIFVNgpYALITTSVSAE 445
Cdd:COG2807 58 LTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTAL-IGAGIAVG--NVLLPGLIKRW 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 446 LGQHSSLegnanalatVTAIIDGTGSIGAAVGPLLAG-LISTAGWQYVFHMLIAADIIAMVLLGRLVFKEFAALRRASHR 524
Cdd:COG2807 135 FPDRVGL---------MTGLYTAAMGLGAALAAGLTVpLAAALGWRGALAVWALLALLALLLWLPLLRRRPAAAAAAPAA 205
|
..
gi 665402485 525 IR 526
Cdd:COG2807 206 AS 207
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
352-526 |
6.27e-03 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 38.64 E-value: 6.27e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 352 IQKSSTLGPELSADLSTLFDVGGILGAIAAGYLSDVSGMSATVCTGM-LFVASPILLMYqqygALSMTISIVLLIVVGIF 430
Cdd:COG0477 40 IAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLlLFGLASLLCGL----APSPELLIAARALQGIG 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402485 431 VngpyALITTSVSAELGQHSslegNANALATVTAIIDGTGSIGAAVGPLLAG-LISTAGWQYVFhmLIAADIIAMVLLGR 509
Cdd:COG0477 116 A----GGLMPGALALIAELF----PARERGRALGLWGAAIGLGLALGPLLGGlLVAALGWRWIF--LINAPLGLLALVLR 185
|
170
....*....|....*..
gi 665402485 510 LVFKEFAALRRASHRIR 526
Cdd:COG0477 186 LRLPESRGLLLALLALA 202
|
|
| |
