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    CG6231 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42339, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG6231provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0038720
    Locus tag
    Dmel_CG6231
    See related
    AllianceGenome:FB:FBgn0038720
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG6231
    Summary
    Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in Lynch syndrome and mismatch repair cancer syndrome. Orthologous to several human genes including SLC22A10 (solute carrier family 22 member 10); SLC22A11 (solute carrier family 22 member 11); and SLC22A12 (solute carrier family 22 member 12). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG6231 in Genome Data Viewer
    Location:
    92A10-92A11; 3-66 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (19616024..19632718, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (15441746..15458440, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene mir-9373 stem loop Neighboring gene subdued Neighboring gene uncharacterized protein Neighboring gene Vacuolar H[+] ATPase 13kD subunit

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. PAF1, a Molecular Regulator of Promoter-Proximal Pausing by RNA Polymerase II. Chen FX, et al. Cell, 2015 Aug 27. PMID 26279188, Free PMC Article
    2. Genetic and metabolomic architecture of variation in diet restriction-mediated lifespan extension in Drosophila. Jin K, et al. PLoS Genet, 2020 Jul. PMID 32644988, Free PMC Article
    3. Highly rearranged chromosomes reveal uncoupling between genome topology and gene expression. Ghavi-Helm Y, et al. Nat Genet, 2019 Aug. PMID 31308546, Free PMC Article
    4. Identification of the Telomere elongation Mutation in Drosophila. Reddy HM, et al. Cells, 2022 Nov 3. PMID 36359878, Free PMC Article
    5. Revisiting the protein-coding gene catalog of Drosophila melanogaster using 12 fly genomes. Lin MF, et al. Genome Res, 2007 Dec. PMID 17989253, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG6231-PA
    CG6231-PB
    CG6231-PC
    CG6231-PD
    CG6231-PE
    CG6231-PF
    organic cation transporter

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      19616024..19632718 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_169865.2 → NP_732436.1  uncharacterized protein Dmel_CG6231, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732436.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SX51, Q9VDV5
      Related
      FBpp0083217
      Conserved Domains (2) summary
      cd06174
      Location:125 → 499
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00898
      Location:11 → 509
      2A0119; cation transport protein

    2. NM_169866.3 → NP_732437.1  uncharacterized protein Dmel_CG6231, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732437.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SX51, Q9VDV5
      Related
      FBpp0083218
      Conserved Domains (2) summary
      cd06174
      Location:125 → 499
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00898
      Location:11 → 509
      2A0119; cation transport protein

    3. NM_001275805.1 → NP_001262734.1  uncharacterized protein Dmel_CG6231, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262734.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SX51, Q9VDV5
      Conserved Domains (2) summary
      cd06174
      Location:125 → 499
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00898
      Location:11 → 509
      2A0119; cation transport protein

    4. NM_169864.2 → NP_732435.1  uncharacterized protein Dmel_CG6231, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732435.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SX51, Q9VDV5
      Related
      FBpp0083219
      Conserved Domains (2) summary
      cd06174
      Location:125 → 499
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00898
      Location:11 → 509
      2A0119; cation transport protein

    5. NM_001275806.1 → NP_001262735.1  uncharacterized protein Dmel_CG6231, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262735.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SX51, Q9VDV5
      Conserved Domains (2) summary
      cd06174
      Location:125 → 499
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00898
      Location:11 → 509
      2A0119; cation transport protein

    6. NM_142562.3 → NP_650819.1  uncharacterized protein Dmel_CG6231, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650819.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SX51, Q9VDV5
      Related
      FBpp0083220
      Conserved Domains (2) summary
      cd06174
      Location:125 → 499
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00898
      Location:11 → 509
      2A0119; cation transport protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SX51 Q8SX51
    Q9VDV5 Q9VDV5

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