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Conserved domains on  [gi|442619939|ref|NP_001262734|]
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uncharacterized protein Dmel_CG6231, isoform E [Drosophila melanogaster]

Protein Classification

MFS transporter( domain architecture ID 1000272)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates; similar to Drosophila melanogaster organic cation transporter protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
2A0119 super family cl36765
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
11-509 4.37e-69

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


The actual alignment was detected with superfamily member TIGR00898:

Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 231.83  E-value: 4.37e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939   11 GDFNRYQFMILALFGFINIIVSMHYFTQTVISFVPDHWCYHDKLVNMTYKEIGEiYAQFENP-----SCTR--LDDIN-- 81
Cdd:TIGR00898   1 GEFGPFQRRTFLLLALPIALLAFHFVLIVFLGATPEHHCRLPDAANLSSRCELN-LTLPRLPdgrpeSCLRfmVDQWAnp 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939   82 -----------GHNVTVSSKACEKWIYNYDFGYRSMNTELNWVCDSAYKARIGQSLFFIGSVVGTLFYGLLSDKIGRVPA 150
Cdd:TIGR00898  80 sllgceplklsDLGLAATEPCLDGWEYSYDTFSSTIVTEWDLVCEDAWKVDLTQSCFFVGVLLGSFVFGYLSDRFGRKKV 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939  151 LILSNFCGFAGDFSTIFTKSVATFTLCRFISGLAADTNFYLMYIIVLEYIRPSMRTLGLNMaVGLFYCLGLVFTPWLAVL 230
Cdd:TIGR00898 160 LLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVVLNTEFLPKKQRAIVGTL-IQVFFSLGLVLLPLVAYF 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939  231 VGHWQIYLACTSLPILLVVLYYFVVQESAQWLVTRNDIDGAIVRLKRVAKFNGCRVSQADFDefrrhcqMTHEMLGGDDK 310
Cdd:TIGR00898 239 IPDWRWLQLAVSLPTFLFFLLSWFVPESPRWLISQGRIEEALKILQRIAKINGKKLPAEVLS-------LSLEKDLSSSK 311
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939  311 KQATLLDMFRTPRMRKNTLILFFKSMVITLCYDAVSRNVEGMGISPFIMFSLSALAVLPSSVLLVLLQDRIGRKGMASGS 390
Cdd:TIGR00898 312 KQYSFLDLFRTPNLRKTTLCLMMLWFTTAFSYYGLVLDLGNLGGNIYLDLFISGLVELPAKLITLLLIDRLGRRYTMAAS 391
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939  391 LLVGGLFTAAAGIAIAYQQhnhnaILLACLTIAARFGVAISYESGSQYATELIPTCVRGQGVAAVHVAGFAASFLAPYIL 470
Cdd:TIGR00898 392 LLLAGVALLLLLFVPVDLY-----FLRTALAVLGKFGITSAFQMVYLYTAELYPTVVRNLGVGVCSTMARVGSIISPFLV 466
                         490       500       510
                  ....*....|....*....|....*....|....*....
gi 442619939  471 WLGTFFKAAPSIILGVLFFAGSFVCLLLPETLNRSLPTT 509
Cdd:TIGR00898 467 YLGEKWLFLPLVLFGGLALLAGILTLFLPETKGVPLPET 505
 
Name Accession Description Interval E-value
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
11-509 4.37e-69

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 231.83  E-value: 4.37e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939   11 GDFNRYQFMILALFGFINIIVSMHYFTQTVISFVPDHWCYHDKLVNMTYKEIGEiYAQFENP-----SCTR--LDDIN-- 81
Cdd:TIGR00898   1 GEFGPFQRRTFLLLALPIALLAFHFVLIVFLGATPEHHCRLPDAANLSSRCELN-LTLPRLPdgrpeSCLRfmVDQWAnp 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939   82 -----------GHNVTVSSKACEKWIYNYDFGYRSMNTELNWVCDSAYKARIGQSLFFIGSVVGTLFYGLLSDKIGRVPA 150
Cdd:TIGR00898  80 sllgceplklsDLGLAATEPCLDGWEYSYDTFSSTIVTEWDLVCEDAWKVDLTQSCFFVGVLLGSFVFGYLSDRFGRKKV 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939  151 LILSNFCGFAGDFSTIFTKSVATFTLCRFISGLAADTNFYLMYIIVLEYIRPSMRTLGLNMaVGLFYCLGLVFTPWLAVL 230
Cdd:TIGR00898 160 LLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVVLNTEFLPKKQRAIVGTL-IQVFFSLGLVLLPLVAYF 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939  231 VGHWQIYLACTSLPILLVVLYYFVVQESAQWLVTRNDIDGAIVRLKRVAKFNGCRVSQADFDefrrhcqMTHEMLGGDDK 310
Cdd:TIGR00898 239 IPDWRWLQLAVSLPTFLFFLLSWFVPESPRWLISQGRIEEALKILQRIAKINGKKLPAEVLS-------LSLEKDLSSSK 311
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939  311 KQATLLDMFRTPRMRKNTLILFFKSMVITLCYDAVSRNVEGMGISPFIMFSLSALAVLPSSVLLVLLQDRIGRKGMASGS 390
Cdd:TIGR00898 312 KQYSFLDLFRTPNLRKTTLCLMMLWFTTAFSYYGLVLDLGNLGGNIYLDLFISGLVELPAKLITLLLIDRLGRRYTMAAS 391
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939  391 LLVGGLFTAAAGIAIAYQQhnhnaILLACLTIAARFGVAISYESGSQYATELIPTCVRGQGVAAVHVAGFAASFLAPYIL 470
Cdd:TIGR00898 392 LLLAGVALLLLLFVPVDLY-----FLRTALAVLGKFGITSAFQMVYLYTAELYPTVVRNLGVGVCSTMARVGSIISPFLV 466
                         490       500       510
                  ....*....|....*....|....*....|....*....
gi 442619939  471 WLGTFFKAAPSIILGVLFFAGSFVCLLLPETLNRSLPTT 509
Cdd:TIGR00898 467 YLGEKWLFLPLVLFGGLALLAGILTLFLPETKGVPLPET 505
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
94-499 1.05e-51

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 180.47  E-value: 1.05e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939  94 KWIYNYDFGYRSMNTELNWVCDSAYKARIGQSLFFIGSVVGTLFYGLLSDKIGRVPALILSNFCGFAGDFSTIFTKSVAT 173
Cdd:cd17317    1 GWEFDYSVSESTIVTEWDLVCDRDWLVALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYEL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 174 FTLCRFISGLAADTNFYLMYIIVLEYIRPSMRTLGlNMAVGLFYCLGLVFTPWLAVLVGHWQIYLACTSLPILLVVLYYF 253
Cdd:cd17317   81 FLVLRFLVGVTSAGIFTVGFVLGMEIVGPKYRSFV-GILFGLFWALGYMLLALLAYLIRDWRWLQLAISLPGLLFLLLLW 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 254 VvqesaqwlvtrndidgaivrlkrvakfngcrvsqadfdefrrhcqmthemlggddkkqatlldmfrTPRMrknTLILFF 333
Cdd:cd17317  160 W------------------------------------------------------------------LPRR---TIIVGL 170
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 334 KSMVITLCYDAVSRNVEGMGISPFIMFSLSALAVLPSSVLLVLLQDRIGRKGMASGSLLVGGLFTAAagIAIAYQQHNHN 413
Cdd:cd17317  171 IWFVTSLVYYGLSLNSSNLGGNLYLNFFLSGLVEIPAYFLALLLLDRLGRRWTLSGSLLLAGLACLV--TALLPDDENTL 248
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 414 AILLACLtiaARFGVAISYESGSQYATELIPTCVRGQGVAAVHVAGFAASFLAPYILWLGTFFKAAPSIILGVLFFAGSF 493
Cdd:cd17317  249 ALTLALV---GKFAISAAFSVIYLYTAELYPTVVRNTGVGLCSTVARVGAILAPFIVLLGKIGPLLPLIIFGVLALLGGL 325

                 ....*.
gi 442619939 494 VCLLLP 499
Cdd:cd17317  326 LTLLLP 331
MFS_1 pfam07690
Major Facilitator Superfamily;
125-467 6.27e-17

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 82.47  E-value: 6.27e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939  125 SLFFIGSVVGTLFYGLLSDKIGRVPALILSNFCGFAGDFSTIFTKSVATFTLCRFISGLAADTNFYLMYIIVLEYIRPSM 204
Cdd:pfam07690  39 TLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEE 118
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939  205 RTLGL---NMAVGLFYCLGLVFTPWLAVLVGhWQ-IYLACTSLPILLVVLYYFVVQESAQWLVTRndidgaivrlkrvak 280
Cdd:pfam07690 119 RGRALglvSAGFGLGAALGPLLGGLLASLFG-WRaAFLILAILSLLAAVLLLLPRPPPESKRPKP--------------- 182
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939  281 fngcrvsqadfdefrrhcqmthemLGGDDKKQATLLDMFRTPRMRKNTLILFFKSMVITLCYDAVSRNVEGMGISPF--- 357
Cdd:pfam07690 183 ------------------------AEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALlag 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939  358 IMFSLSALAVLPSSVLLVLLQDRIGRKGMasgsLLVGGLFTAAAGIAIAYQQHNHNAILLACLTIAARFGVAISYESGSQ 437
Cdd:pfam07690 239 LLLGLGGLLGAIGRLLLGRLSDRLGRRRR----LLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNA 314
                         330       340       350
                  ....*....|....*....|....*....|
gi 442619939  438 YATELIPTCVRGQGVAAVHVAGFAASFLAP 467
Cdd:pfam07690 315 LVSDLAPKEERGTASGLYNTAGSLGGALGP 344
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
125-466 3.46e-15

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 77.32  E-value: 3.46e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 125 SLFFIGSVVGTLFYGLLSDKIGRVPALILSNFCGFAGDFSTIFTKSVATFTLCRFISGLAADTNFYLMYIIVLEYIRPSM 204
Cdd:COG2814   52 TAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPER 131
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 205 RT--LGLNMAVGLF-YCLGLVFTPWLAVLVGHWQIYLACTSLPILLVVLYYFVVQESAQWLVTRndidgaivrlkrvakf 281
Cdd:COG2814  132 RGraLGLLGAGLGLgPALGPLLGGLLADLFGWRWVFLVNAVLALLALLLLLRLLPESRPAARAR---------------- 195
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 282 ngcrvsqadfdefrrhcqmthemlggddkKQATLLDMFRTPRMRKNTLILFFKSMVITLCYDAVS-RNVEGMGISPF--- 357
Cdd:COG2814  196 -----------------------------LRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPlYLQEVLGLSASaag 246
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 358 IMFSLSALAVLPSSVLLVLLQDRIGRKgmasgSLLVGGLFTAAAGIAIAYQQHNHNAILLACLTIAarFGVAISYESGSQ 437
Cdd:COG2814  247 LLLALFGLGGVLGALLAGRLADRFGRR-----RLLLIGLLLLALGLLLLALAGSLWLLLLALFLLG--FGFGLLFPLLQA 319
                        330       340
                 ....*....|....*....|....*....
gi 442619939 438 YATELIPTCVRGQGVAAVHVAGFAASFLA 466
Cdd:COG2814  320 LVAELAPPEARGRASGLYNSAFFLGGPLA 348
PRK11043 PRK11043
Bcr/CflA family multidrug efflux MFS transporter;
125-185 1.27e-04

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182924 [Multi-domain]  Cd Length: 401  Bit Score: 44.50  E-value: 1.27e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 442619939 125 SLFFIGSVVGTLFYGLLSDKIGRVPALI--LSNFCgfAGDFSTIFTKSVATFTLCRFISGLAA 185
Cdd:PRK11043  48 SLFLAGFALGQLLWGPLSDRYGRKPVLLagLSLFA--LGSLGMLWVESAAQLLVLRFVQAVGV 108
 
Name Accession Description Interval E-value
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
11-509 4.37e-69

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 231.83  E-value: 4.37e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939   11 GDFNRYQFMILALFGFINIIVSMHYFTQTVISFVPDHWCYHDKLVNMTYKEIGEiYAQFENP-----SCTR--LDDIN-- 81
Cdd:TIGR00898   1 GEFGPFQRRTFLLLALPIALLAFHFVLIVFLGATPEHHCRLPDAANLSSRCELN-LTLPRLPdgrpeSCLRfmVDQWAnp 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939   82 -----------GHNVTVSSKACEKWIYNYDFGYRSMNTELNWVCDSAYKARIGQSLFFIGSVVGTLFYGLLSDKIGRVPA 150
Cdd:TIGR00898  80 sllgceplklsDLGLAATEPCLDGWEYSYDTFSSTIVTEWDLVCEDAWKVDLTQSCFFVGVLLGSFVFGYLSDRFGRKKV 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939  151 LILSNFCGFAGDFSTIFTKSVATFTLCRFISGLAADTNFYLMYIIVLEYIRPSMRTLGLNMaVGLFYCLGLVFTPWLAVL 230
Cdd:TIGR00898 160 LLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVVLNTEFLPKKQRAIVGTL-IQVFFSLGLVLLPLVAYF 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939  231 VGHWQIYLACTSLPILLVVLYYFVVQESAQWLVTRNDIDGAIVRLKRVAKFNGCRVSQADFDefrrhcqMTHEMLGGDDK 310
Cdd:TIGR00898 239 IPDWRWLQLAVSLPTFLFFLLSWFVPESPRWLISQGRIEEALKILQRIAKINGKKLPAEVLS-------LSLEKDLSSSK 311
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939  311 KQATLLDMFRTPRMRKNTLILFFKSMVITLCYDAVSRNVEGMGISPFIMFSLSALAVLPSSVLLVLLQDRIGRKGMASGS 390
Cdd:TIGR00898 312 KQYSFLDLFRTPNLRKTTLCLMMLWFTTAFSYYGLVLDLGNLGGNIYLDLFISGLVELPAKLITLLLIDRLGRRYTMAAS 391
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939  391 LLVGGLFTAAAGIAIAYQQhnhnaILLACLTIAARFGVAISYESGSQYATELIPTCVRGQGVAAVHVAGFAASFLAPYIL 470
Cdd:TIGR00898 392 LLLAGVALLLLLFVPVDLY-----FLRTALAVLGKFGITSAFQMVYLYTAELYPTVVRNLGVGVCSTMARVGSIISPFLV 466
                         490       500       510
                  ....*....|....*....|....*....|....*....
gi 442619939  471 WLGTFFKAAPSIILGVLFFAGSFVCLLLPETLNRSLPTT 509
Cdd:TIGR00898 467 YLGEKWLFLPLVLFGGLALLAGILTLFLPETKGVPLPET 505
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
94-499 1.05e-51

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 180.47  E-value: 1.05e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939  94 KWIYNYDFGYRSMNTELNWVCDSAYKARIGQSLFFIGSVVGTLFYGLLSDKIGRVPALILSNFCGFAGDFSTIFTKSVAT 173
Cdd:cd17317    1 GWEFDYSVSESTIVTEWDLVCDRDWLVALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYEL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 174 FTLCRFISGLAADTNFYLMYIIVLEYIRPSMRTLGlNMAVGLFYCLGLVFTPWLAVLVGHWQIYLACTSLPILLVVLYYF 253
Cdd:cd17317   81 FLVLRFLVGVTSAGIFTVGFVLGMEIVGPKYRSFV-GILFGLFWALGYMLLALLAYLIRDWRWLQLAISLPGLLFLLLLW 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 254 VvqesaqwlvtrndidgaivrlkrvakfngcrvsqadfdefrrhcqmthemlggddkkqatlldmfrTPRMrknTLILFF 333
Cdd:cd17317  160 W------------------------------------------------------------------LPRR---TIIVGL 170
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 334 KSMVITLCYDAVSRNVEGMGISPFIMFSLSALAVLPSSVLLVLLQDRIGRKGMASGSLLVGGLFTAAagIAIAYQQHNHN 413
Cdd:cd17317  171 IWFVTSLVYYGLSLNSSNLGGNLYLNFFLSGLVEIPAYFLALLLLDRLGRRWTLSGSLLLAGLACLV--TALLPDDENTL 248
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 414 AILLACLtiaARFGVAISYESGSQYATELIPTCVRGQGVAAVHVAGFAASFLAPYILWLGTFFKAAPSIILGVLFFAGSF 493
Cdd:cd17317  249 ALTLALV---GKFAISAAFSVIYLYTAELYPTVVRNTGVGLCSTVARVGAILAPFIVLLGKIGPLLPLIIFGVLALLGGL 325

                 ....*.
gi 442619939 494 VCLLLP 499
Cdd:cd17317  326 LTLLLP 331
MFS_OAT cd17374
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ...
95-499 1.77e-31

Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340932 [Multi-domain]  Cd Length: 341  Bit Score: 125.10  E-value: 1.77e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939  95 WIYNYDFGYRSMNTELNWVCDSAYKARIGQSLFFIGSVVGTLFYGLLSDKIGRVPALILSNFCGFAGDFSTIFTKSVATF 174
Cdd:cd17374   12 WVYDRSKFTSTIVTEWDLVCESQSLKSVAQSIFMAGLLVGALIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAPTFPVY 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 175 TLCRFISGLAADTNFYLMYIIVLEYIRPSMRTLGLnMAVGLFYCLGLVFTPWLAVLVGHWQIYLACTSLPILLVVLYYFv 254
Cdd:cd17374   92 CVLRFLAGFAVSGISINTLILGTEWTTPRHRALAI-TLTSCFFSIGQMLLAGLAYAIRDWRLLQLVVSVPFFLFFLYSW- 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 255 vqesaqWLVTRndidgaivrlkrvakfngcrvsqadfdefrrhcqmthemlggddkkqatlldmfrtprmrknTLILFFK 334
Cdd:cd17374  170 ------WLPKR--------------------------------------------------------------TLILSFV 181
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 335 SMVITLCYDAVSRNVEGMGISPFIMFSLSALAVLPSSVLLVLLQDRIGRKGMASGSLLVGGLFTAAagIAIAYQQHNHNA 414
Cdd:cd17374  182 WFANSFSYYGLSLDLQHLGLNVFLLQFLFGAVEVPARCLALFLLNHMGRRISQAVLLLLAGLCILA--NIFVPQEMQTLR 259
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 415 ILLACLtiaARFGVAISYESGSQYATELIPTCVRGQGVAAVHVAGFAASFLAPYILWLGTFFKAAPSIILGVLFFAGSFV 494
Cdd:cd17374  260 TVLAVL---GKGSSAAAFTISYVYTAELFPTVLRQTGMGLNSMFARIGGILAPLIMLLGVYSPLLPMIIYGVLPILAGLL 336

                 ....*
gi 442619939 495 CLLLP 499
Cdd:cd17374  337 ALLLP 341
MFS_SLC22A4_5_OCTN1_2 cd17376
Solute carrier family 22 members 4 and 5 (also called Organic cation/carnitine transporters 1 ...
95-499 9.28e-30

Solute carrier family 22 members 4 and 5 (also called Organic cation/carnitine transporters 1 and 2) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 22 members 4 (SLC22A4) and 5 (SLC22A5), and similar proteins. SLC22A4 is also called ergothioneine transporter (ETT) or organic cation/carnitine transporter 1 (OCTN1). It is a sodium-ion dependent, low affinity carnitine transporter, and a highly specific transporter for the uptake of ergothioneine (ET), a thiolated derivative of histidine with antioxidant properties. ET is a natural compound produced only by certain fungi and bacteria and must be absorbed from the diet by humans and other vetebrates. SLC22A5, also called organic cation/carnitine transporter 2 (OCTN2), is a sodium-ion dependent, high affinity carnitine transporter involved in the active cellular uptake of carnitine. SLC22A4/5 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340934 [Multi-domain]  Cd Length: 342  Bit Score: 120.26  E-value: 9.28e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939  95 WIYNYDFGYRSMNTELNWVCDSAYKARIGQSLFFIGSVVGTLFYGLLSDKIGRVPALILSNFCGFAGDFSTIFTKSVATF 174
Cdd:cd17376   12 WEYSQDVYLSTIVTEWNLVCEDDWKVPLTTSLFFVGVLLGSFISGQLSDRFGRKKVLFATMAVQTGFSFLQIFSPSWEMF 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 175 TLCRFISGLAADTNFYLMYIIVLEYIRPSMRTLGLNMAVGLFYCLGLVFTPWLAVLVGHWQIYLACTSLPILLVV-LYYF 253
Cdd:cd17376   92 TVLFVIVGMGQISNYVVAFVLGTEILGKSVRILFSTLGVCIFYAIGYMLLPLFAYFIRDWRMLLLALTLPGVLCVpLWWF 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 254 VvqesaqwlvtrndidgaivrlkrvakfngcrvsqadfdefrrhcqmthemlggddkkqatlldmfrtPRMRKNTLILFf 333
Cdd:cd17376  172 I-------------------------------------------------------------------PITTIMSLLLW- 183
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 334 ksMVITLCYDAVSRNVEGMGISPFIMFSLSALAVLPSSVLLVLLQDRIGRKGMASGSLLVGGLFTAAagIAIAYQQHNHN 413
Cdd:cd17376  184 --MAISVGYFGLSLNTPNLHGDPYLNCFLSAVIEVPAYIIAWLLLRSLPRRYSIAATLVLGGGVLLF--IQLVPTDLQVL 259
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 414 AIllaCLTIAARFGVAISYESGSQYATELIPTCVRGQGVAAVHVAGFAASFLAPYILWLGTFFKAAPSIILGVLFFAGSF 493
Cdd:cd17376  260 AT---ALVMLGKFGITAAFSMVYVYTAELYPTVVRNMGVGVCSTASRIGSIISPYFVYLGAYDRYLPYILMGSLTVLIGI 336

                 ....*.
gi 442619939 494 VCLLLP 499
Cdd:cd17376  337 LTLFLP 342
MFS_SLC22A1_2_3 cd17379
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ...
91-499 7.64e-21

Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340937 [Multi-domain]  Cd Length: 340  Bit Score: 93.95  E-value: 7.64e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939  91 ACEKWIYnYDFGYRSMNTELNWVCDSAYKARIGQSLFFIGSVVGTLFYGLLSDKIGRVPALILSNFCGFAGDFSTIFTKS 170
Cdd:cd17379    7 PCQDGWV-YNTPRSSIVTEFNLVCEDAWKLDLFQSSLNLGFLIGSIVIGYLADRFGRKVCFLISILGNGVSGVLMAFSPN 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 171 VATFTLCRFISGLAADTNFYLMYIIVLEYIRPSMR-TLGLnmAVGLFYCLGLVFTPWLAVLVGHWQIYLACTSLPILLVV 249
Cdd:cd17379   86 YPWFLIFRFLQGLFGKGGWMTGYVLVTEFVGSKYRrTVGI--VYQMFFTLGLLILPGIAYFIPHWRWLQLAVTLPNFLFL 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 250 LYYFVVQesaqwlvtrndidgaivrlkrvakfngcrvsqadfdefrrhcqmthemlggddkkqatlldmfrtprmrKNTL 329
Cdd:cd17379  164 LYYWFIP---------------------------------------------------------------------KHTF 174
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 330 ILFFKSMVITLCYDAVSRNVEGMGISPFIMFSLSALAVLPSSVLLVLLQDRIGRKGMASGSLLVGGlftaAAGIAIAYQQ 409
Cdd:cd17379  175 ILMYAWFTSAVVYQGLIMRLGITGGNLYLDFFISALVELPAAFIILLTIDRIGRRLPFAASNIVAG----AACLITAFIP 250
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 410 HNHN--AILLACLtiaARFGVAISYESGSQYATELIPTCVRGQGVAAVHVAGFAASFLAPYILW-LGTFFKAAPSIILGV 486
Cdd:cd17379  251 PDLHwlKTTIACV---GRLGITMAFEIVCLVNTELYPTFLRNLGVSVCSSLCDIGGIIAPFLLYrLAEIWLELPLIVFGV 327
                        410
                 ....*....|...
gi 442619939 487 LFFAGSFVCLLLP 499
Cdd:cd17379  328 LALVAGGLVLLLP 340
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
125-506 9.33e-20

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 91.87  E-value: 9.33e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 125 SLFFIGSVVGTLFYGLLSDKIGRVPALILSNFCGFAGDFSTIFTKSVATFTLCRFISGLAADTNFYL--MYI--IVLEYI 200
Cdd:cd17358   48 SLLTLGALIGALLSGKLADRIGRKRTLLISAIPCILGWLLIAFAKDVWMLYLGRFLAGFGGGAASVVvpVYIaeIAPKNV 127
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 201 R---PSMRTLGLNMAVGLFYCLGLvFTPWLAVLvghwqiyLACTSLPILLVVLYYFvVQESAQWLVTRNDIDGAIVRLKR 277
Cdd:cd17358  128 RgalGSLNQLLVNIGILLGYVLGS-FLPWRTLA-------LIGAIPPVVFLILLFF-IPESPRWLAKKGREEEAEKSLQF 198
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 278 vakFNGCRVS-QADFDEFRRHCQMTHEMLggddkKQATLLDMFRtPRMRKNTLIlffkSMVITLCYDAVSRNVE------ 350
Cdd:cd17358  199 ---LRGKDADiSKEAAEIQEELAELEKEA-----KESSFSDLFQ-RKYLKPLVI----GLGLMLFQQLSGINAVifyass 265
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 351 -----GMGISPFIMFSLSALAVLPSSVLLVLLQDRIGRK--GMASGSLLvgGLFTAAAGIAIAYQQHNHNAILLACLTIA 423
Cdd:cd17358  266 ifdeaGSGLDPNTATIIIGVVQVVGTLVATLLVDRLGRRplLLVSAIGM--GIGLLALGLYFYLQEHGALLSSVSWLPLV 343
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 424 ARFGVAISYESG---------SqyatELIPTCVRGqgvAAVHVAGFAASFLAPYILWLGTFFKAAPSIILGVLFFAGS-- 492
Cdd:cd17358  344 GLVIYIISFSIGlgplpwvimS----EIFPAKIKG---LAGSLVTLVNWLFAFIVTKTFPFLTLAWGASGTFWIFAGIcg 416
                        410
                 ....*....|....*...
gi 442619939 493 ----FVCLLLPETLNRSL 506
Cdd:cd17358  417 lalvFVLLFVPETKGKSL 434
MFS_OCT_plant cd17378
Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of ...
114-499 4.79e-19

Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of transporters; Plant organic cation/carnitine transporters (OCTs) are sequence-similar to their animal counterparts, which are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. Little is know about plant OCTs. In Arabidopsis, there are six genes belonging to this family that show distinct, organ-specific expression pattern of the individual genes. AtOCT1 has been found to affect root development and carnitine-related responses in Arabidopsis. AtOCT4, 5 and 6 are up-regulated during drought stress, AtOCT3 and 5 during cold stress and AtOCT5 and 6 during salt stress treatments. Plant OCTs belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340936 [Multi-domain]  Cd Length: 342  Bit Score: 88.57  E-value: 4.79e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 114 CDSAYKARIGQSLFFIGSVVGTLFYGLLSD-KIGRVPALILSNFCGFAGDFSTIFTKSVATFTLCRFISGLAADTNFYLM 192
Cdd:cd17378   29 CAGSFLVGLPQSSFFVGCLIGSGVLGHLADsSLGRKNLLFLSCLLMALSGIATAFSPNYWVYAFLRFLTGFGRSGIGTCA 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 193 YIIVLEYIRPSMRTLgLNMAVGLFYCLGLVFTPWLAVLVGH-WQIYLACTSLP--ILLVVLYYFVvqesaqwlvtrndid 269
Cdd:cd17378  109 LVLATEPVGPKWRGQ-VGMSTFFFFVLGFMSLPGIAYLNGSsWRVLYFWTSIPalIYCILVYLFA--------------- 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 270 gaivrlkrvakfngcrvsqadfdefrrhcqmthemlggddkkqatlldmfrtPRMRKNTLILFFKSMVitlcYDAVSRNV 349
Cdd:cd17378  173 ----------------------------------------------------RRLLAVMVIGFGIGMV----YYGIPLAV 196
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 350 EGMGISPFIMFSLSALAVLPSSVLLVLLQDRIGRKGMASGSLLVGGLFTAAAGIAIAYQQhnhNAILLACLTIaARFGVA 429
Cdd:cd17378  197 GNLKFNIYLSVALNALSELPAFVITAFLLDRFGRRPSLLGFTLLSGASCLLCFVLSIGGT---TSLQIALELV-GFFGAA 272
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 430 ISYESGSQYATELIPTCVRGQGVAAVHVAGFAASFLAPYILWLGTFFKAAPSIILGVLFFAGSFVCLLLP 499
Cdd:cd17378  273 GAFNLLYIYTVELFPTCVRNAALGMLRQALVVGGIFAPFIVSLGRKNAALSFGVFGVAILLLGLFALGLP 342
MFS_1 pfam07690
Major Facilitator Superfamily;
125-467 6.27e-17

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 82.47  E-value: 6.27e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939  125 SLFFIGSVVGTLFYGLLSDKIGRVPALILSNFCGFAGDFSTIFTKSVATFTLCRFISGLAADTNFYLMYIIVLEYIRPSM 204
Cdd:pfam07690  39 TLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEE 118
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939  205 RTLGL---NMAVGLFYCLGLVFTPWLAVLVGhWQ-IYLACTSLPILLVVLYYFVVQESAQWLVTRndidgaivrlkrvak 280
Cdd:pfam07690 119 RGRALglvSAGFGLGAALGPLLGGLLASLFG-WRaAFLILAILSLLAAVLLLLPRPPPESKRPKP--------------- 182
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939  281 fngcrvsqadfdefrrhcqmthemLGGDDKKQATLLDMFRTPRMRKNTLILFFKSMVITLCYDAVSRNVEGMGISPF--- 357
Cdd:pfam07690 183 ------------------------AEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALlag 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939  358 IMFSLSALAVLPSSVLLVLLQDRIGRKGMasgsLLVGGLFTAAAGIAIAYQQHNHNAILLACLTIAARFGVAISYESGSQ 437
Cdd:pfam07690 239 LLLGLGGLLGAIGRLLLGRLSDRLGRRRR----LLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNA 314
                         330       340       350
                  ....*....|....*....|....*....|
gi 442619939  438 YATELIPTCVRGQGVAAVHVAGFAASFLAP 467
Cdd:pfam07690 315 LVSDLAPKEERGTASGLYNTAGSLGGALGP 344
Sugar_tr pfam00083
Sugar (and other) transporter;
125-506 1.46e-16

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 82.32  E-value: 1.46e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939  125 SLFFIGSVVGTLFYGLLSDKIGRVPALILSNFCGFAGDFSTIFTKSVATF---TLCRFISGLAADTNFYL--MYIIvlEY 199
Cdd:pfam00083  53 SIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKGKWSVyqlIVGRVLVGIGVGGASVLapMYIS--EI 130
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939  200 IRPSMR-TLG----LNMAVGLF--YCLGLVFTpwLAVLVGHWQIYLACTSLPILLVVLYYFVVQESAQWLVTRNDIDGAi 272
Cdd:pfam00083 131 APKKLRgALGslyqLAITFGILlaYIFGLGLN--KTSNSDGWRIPLGLQLVPALLLIIGLLFLPESPRWLVEKGRLEEA- 207
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939  273 vrlKRV-AKFNGCRVSQADFDEfrrhcqMTHEMLGGDDKKQATLLDMFRTPRMRKNTLILFFKSMVITLCYDAVSrnveg 351
Cdd:pfam00083 208 ---REVlAKLRGVPDVDRELDE------IKDSLEAGQEAEKASWKELFSTKTRRQRLLIGVMLQIFQQLTGINAI----- 273
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939  352 MGISPFIM----FSLSALAVLPSSVLLVLLQ-------DRIGRKGMasgsLLVGGLFTAAAGIAIAYQQH--NHNAILLA 418
Cdd:pfam00083 274 FYYSTTIFenlgLSDSFLVTIIVGVVNFVFTfiaiflvDRFGRRPL----LLLGAAGMAICFVILGIVALlgVSKSDWAG 349
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939  419 CLTIAARFGVAISYESG-----SQYATELIPTCVR--GQGVAAV--HVAGFAASFLAPYIL----WLGTFFkaapsIILG 485
Cdd:pfam00083 350 IVAIVFIALFIAFFAMGwgpvpWVIVSELFPLSVRskAMALATAanWLANFLIGFLFPIITdaigLGYTFF-----IFAG 424
                         410       420
                  ....*....|....*....|.
gi 442619939  486 VLFFAGSFVCLLLPETLNRSL 506
Cdd:pfam00083 425 LLVLFIIFVFFFVPETKGRTL 445
MFS_SLC22A31 cd17443
Solute carrier family 22, member 31 of the Major Facilitator Superfamily; Solute carrier ...
108-469 2.49e-16

Solute carrier family 22, member 31 of the Major Facilitator Superfamily; Solute carrier family 22, member 31 (SLC22A31) is an uncharacterized member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A31 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341001 [Multi-domain]  Cd Length: 343  Bit Score: 80.59  E-value: 2.49e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 108 TELNWVCDSAYKARIGQSLFFIGSVVGTLFYGLLSDKIGRVPALILSNFCGFAGDFSTIFTKSVATFTLCRFISGLAADT 187
Cdd:cd17443   26 TEWNLVCDDGWKVPLEKISYLLGWLLGYIILGAGCDRLGRRAAFVLSLVLATLLGVSVALSASPPTFLVLRLLQGGTLAG 105
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 188 NFYLMYIIVLEYIRPSMRtLGLNMAVGLFYCLGLVFTPWLAVLVGHWQIYLACTSLPILLVVLYYfvvqesaqwlvtrnd 267
Cdd:cd17443  106 VFLSLYIARLELCDPSHR-LMVSMGAGFFSVAGELLLPGLAVLCRDWRVLQGVGTLPLLLLLLYW--------------- 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 268 idgaivrlkrvakfngCRVSqadfdefrrhcqmthemlggddkkqatlldmfrtprmrKNTLILFFKSMV---ITLCYda 344
Cdd:cd17443  170 ----------------CFPS--------------------------------------RNGLILGFTAFIgggIRYCF-- 193
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 345 vSRNVEGMGISPFIMFSLSALAVLPSSVLLVLLQDRIGRKGMasgsLLVGGLFTAAAG---IAIAYQQHNHNAILLACLT 421
Cdd:cd17443  194 -ARNLAPFVPTFYLPYFLQAGLEALACIFLCLTVDRCGRRGV----LLLGTIVTGLSSlllLALTQYLHGGLVLVLSVVG 268
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*...
gi 442619939 422 IAARFGVAIsyeSGSQYATELIPTCVRGQGVAAVHVAGFAASFLAPYI 469
Cdd:cd17443  269 LLASHAVSM---LSMFFAAEVLPTVIRGAGLGLIMGAGFLGRAAGPLM 313
MFS_SLC22A16_CT2 cd17375
Solute carrier family 22 member 16 (also called Carnitine transporter 2) of the Major ...
88-499 2.48e-15

Solute carrier family 22 member 16 (also called Carnitine transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 16 (SLC22A16) is also called carnitine transporter 2 (CT2), fly-like putative transporter 2 (FLIPT2), organic cation transporter OKB1, or organic cation/carnitine transporter 6 (OCT6). It is a partially sodium-ion dependent high affinity carnitine transporter. It also transports organic cations such as tetraethylammonium (TEA) and doxorubicin. It is one of several organic cation transporters (OCTs) that falls into the SLC22 (solute carrier 22) family. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. SLC22A16 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340933 [Multi-domain]  Cd Length: 341  Bit Score: 77.48  E-value: 2.48e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939  88 SSKACEKWIYNYDFGYRSMNTELNWVCDSAYKARIGQSLFFIGSVVGTLFYGLLSDKIGRVPALILSNFCGFAGDFSTIF 167
Cdd:cd17375    5 RFSCSDGFVYDQSKWESSIVTDWDLVCDREWLAKLIQPIFMLGVLLGAVIFGDIADRIGRRPVLWFTSTGQFVFGIAVAF 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 168 TKSVATFTLCRFISGLAADTNFYLMYIIVLEYIRPSMRTLGlNMAVGLFYCLGLVFTPWLAVLVGHW---QIYLACTSLP 244
Cdd:cd17375   85 TFDYYSFVIVRFLLAMVSSGYLVVVFVYVTEFTGIKARTWA-SMHVHAFFAVGIMVVALVGYLVRTWwiyQIILSLVTIP 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 245 ILLVVlyyfvvqesaqWLVtrndidgaivrlkrvakfngcrvsqadfdefrrhcqmthemlggddkkqatlldmfrtPRM 324
Cdd:cd17375  164 FILCC-----------WML----------------------------------------------------------PKR 174
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 325 rknTLILFFKSMVITLCYDAVSRNVEGMGISPFIMFSLSALAVLPSSVLLVLLQDRIGRKGMASGSLLVGGLftAAAGIA 404
Cdd:cd17375  175 ---TITVWLIWFTGSLGYYVFSLGSVNLGGNEYLNLFLVGAVEIPSYIIACIGMDKLGRRNTLAPFLLLSAL--ACMLIM 249
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 405 IAYQQHNHNAILLAcltIAARFGVAISYESGSQYATELIPTCVRGQGVAAVHVAGFAASFLAPYILWLGTFFKAAPSIIL 484
Cdd:cd17375  250 VIPQDYEVLTIVLS---MTGKFAIAIAFGLIYLYTAELYPTIVRSLAVGSGSMMCRVGSVVAPFCVYLSDVWIFLPQLLV 326
                        410
                 ....*....|....*
gi 442619939 485 GVLFFAGSFVCLLLP 499
Cdd:cd17375  327 GIMAFLSGILTLMLP 341
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
125-466 3.46e-15

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 77.32  E-value: 3.46e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 125 SLFFIGSVVGTLFYGLLSDKIGRVPALILSNFCGFAGDFSTIFTKSVATFTLCRFISGLAADTNFYLMYIIVLEYIRPSM 204
Cdd:COG2814   52 TAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPER 131
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 205 RT--LGLNMAVGLF-YCLGLVFTPWLAVLVGHWQIYLACTSLPILLVVLYYFVVQESAQWLVTRndidgaivrlkrvakf 281
Cdd:COG2814  132 RGraLGLLGAGLGLgPALGPLLGGLLADLFGWRWVFLVNAVLALLALLLLLRLLPESRPAARAR---------------- 195
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 282 ngcrvsqadfdefrrhcqmthemlggddkKQATLLDMFRTPRMRKNTLILFFKSMVITLCYDAVS-RNVEGMGISPF--- 357
Cdd:COG2814  196 -----------------------------LRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPlYLQEVLGLSASaag 246
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 358 IMFSLSALAVLPSSVLLVLLQDRIGRKgmasgSLLVGGLFTAAAGIAIAYQQHNHNAILLACLTIAarFGVAISYESGSQ 437
Cdd:COG2814  247 LLLALFGLGGVLGALLAGRLADRFGRR-----RLLLIGLLLLALGLLLLALAGSLWLLLLALFLLG--FGFGLLFPLLQA 319
                        330       340
                 ....*....|....*....|....*....
gi 442619939 438 YATELIPTCVRGQGVAAVHVAGFAASFLA 466
Cdd:COG2814  320 LVAELAPPEARGRASGLYNSAFFLGGPLA 348
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
125-496 8.46e-15

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 76.10  E-value: 8.46e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 125 SLFFIGSVVGTLFYGLLSDKIGRVPALILSNFCGFAGDFSTIFTKSVATFTLCRFISGLAADTNFYLMYIIVLEYIRPSM 204
Cdd:cd17316   43 AAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKR 122
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 205 RTLGLNMAVGlFYCLGLVFTPWLAVLVGH-------WQIYLACTSLPILLVVLyyfvvqesaqwlvtrndidgaivrlkr 277
Cdd:cd17316  123 RGFALGLLQS-GWALGALLAALVASLLIPllsgdwgWRILFLIGALPALLALL--------------------------- 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 278 vakfngcrvsqadfdefrrhcqmthemlggddkkqatlldmfrtprMRKNTLILFFKSMVITLCYDAVS-------RNVE 350
Cdd:cd17316  175 ----------------------------------------------LRRRTLLLILLWFFISFGYYGLTtflptylQTVL 208
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 351 GMGIS-PFIMFSLSALAVLPSSVLLVLLQDRIGRKGMasgslLVGGLFTAAAGIAIAYQQHNHNAILLACLTIAARFGVA 429
Cdd:cd17316  209 GLSPAtSSLYLLLISLGALVGALIAGLLSDRIGRKKT-----LVIGLILSGILALPLFYLLSGSPTLLLLLLFILSFFVG 283
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 430 ISYESGSQYATELIPTCVRGQGVAAVHVAGFAASFLAPYIL-WL--GTFFKAAPSIILGVLFFAGSFVCL 496
Cdd:cd17316  284 GVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIaLLlaSTGGTGVPALILALLAIVALIVAL 353
MFS_SLC22A6_OAT1_like cd17446
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar ...
95-251 1.15e-14

Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar transporters of the Major Facilitator Superfamily; This subfamily includes solute carrier family 22 member 6 (SLC22A6, also called organic anion transporter 1 or OAT1 or para-aminohippurate (PAH) transporter), SLC22A8 (or OAT3), and SLC22A20 (or OAT6). OAT1 and OAT3 are involved in the renal elimination of endogenous and exogenous organic anions (OAs). They function as OA exchangers, coupling the uptake of OAs against an electrochemical gradient with the efflux of intracellular dicarboxylates. SLC22A20 is an OA transporter that mediates the uptake of estrone sulfate. The OAT1-like subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341004 [Multi-domain]  Cd Length: 339  Bit Score: 75.53  E-value: 1.15e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939  95 WIYNYDFGYRSMNTELNWVCDSAYKARIGQSLFFIGSVVGTLFYGLLSDKIGRVPALILSNFCGFAGDFSTIFTKSVATF 174
Cdd:cd17446   10 WVYDKSEFPSTIITEWDLVCNHRALRQLAQSIYMAGVLVGAIVFGGLSDRFGRRPLLIWSYLQMAVSGTCAAFSPSFPIY 89
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 442619939 175 TLCRFISGLAADTNFYLMYIIVLEYIRPSMRTLgLNMAVGLFYCLGLVFTPWLAVLVGHWQIYLACTSLPILLVVLY 251
Cdd:cd17446   90 CVFRFLTGMALSGIVLNSVSLNVEWMPTRVRAV-VGTLLGYCYTLGQLILAGVAYAIRDWRWLQLAVSLPFFIFFLY 165
MFS_GLUT_Class1_2_like cd17357
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ...
125-504 1.42e-14

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340915 [Multi-domain]  Cd Length: 447  Bit Score: 76.15  E-value: 1.42e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 125 SLFFIGSVVGTLFYGLLSDKIGRVPALILSNFCGFAGDFSTIF---TKSVATFTLCRFISGLAA--DTNFYLMYiivLEY 199
Cdd:cd17357   56 SIFFIGGAIGSFISAFLANRFGRKNGLLISNALLVVSSLLMFLsksAKSPELLIFGRFLVGIACglSTGFVPMY---LQE 132
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 200 IRPSmrtlGLNMAVGLFYCLGLVFTPWLAVLVG---------HWQIYLACTSLPILLVVLYYFVVQESAQWLV-TRNDID 269
Cdd:cd17357  133 ISPS----ELRGALGSLTQIGVTLGILLGQVFGlpsvlgtetLWPYLLFFPGIPALLQLAALPFFPESPKFLLiSKGDEE 208
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 270 GAIVRLKRvakFNGC--RVSQADFDEFRRHCQMTHEmlggddkKQATLLDMFRTPRMRKNTL----------------IL 331
Cdd:cd17357  209 EAEKSLKF---LRGIedDVDQELEEIKKESEQMGDQ-------KQVSLMQLLRDPSLRLPLLlvlvvsasqqfsginaIF 278
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 332 FFKSMVIT---LCYDAVSRNVEGMGISPFIMFSLSALAVlpssvllvllqDRIGRKGMASGSLLVGGLFTAAAGIAIAYQ 408
Cdd:cd17357  279 FYSTFIFEnagFSPQLAEWANLGIGIVNVLSTIVGPFLI-----------EKVGRRPLLLISLSVCAVALLLMSVFLFLS 347
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 409 QHNHNailLACLTIAARFGVAISYESGSQ-----YATELIPTCVR----GQGVAAVHVAGFAASFLAPYILWLGTFFKAA 479
Cdd:cd17357  348 EQNSW---MSYGCIVAIFLFIFFFAIGLGpipwfIGAELFPQAPRsaaqSLGSSVNWTSNFIVGMAFPPLQSIGGGFVFI 424
                        410       420
                 ....*....|....*....|....*
gi 442619939 480 PSIILGVLFFAgsFVCLLLPETLNR 504
Cdd:cd17357  425 IFAIPCALFLL--YLYRYLPETKGR 447
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
129-469 3.08e-14

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 74.70  E-value: 3.08e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939  129 IGSVVGTLFYGLLSDKIGRVPALILSNFCGFAGDFSTIFTKSVATFTLCRFISGLAADTNFYLMYIIVLEYIRPSMRTLg 208
Cdd:TIGR00895  63 IGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGT- 141
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939  209 lnmAVGLFYC-------LGLVFTPWLAVLVGhWQI-YLACTSLPILLVVLYYFVVQESAQWLVTRNDiDGAIVRLKRVAk 280
Cdd:TIGR00895 142 ---AVGLMFCgypigaaVGGFLAGWLIPVFG-WRSlFYVGGIAPLLLLLLLMRFLPESIDFLVSKRP-ETVRRIVNAIA- 215
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939  281 fngcrvsqadfDEFRRHCQMTHEMLGGDDKKQATLLDMFRTPRMRKNTLILFfksmvitLCYDAVSRNVEGMGI-SPFIM 359
Cdd:TIGR00895 216 -----------PQMQAEAQSALPEQKSTQGTKRSVFKALFQGKTARITVLLW-------LLYFMLLVGVYFLTNwLPKLM 277
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939  360 ------FSLSALAVLPSSV-------LLVLLQDRIGRKGMASGSLLvgglftAAAGIAIAYQQHNHNAILLACLTIAARF 426
Cdd:TIGR00895 278 velgfsLSLAATGGALFNFggvigsiIFGWLADRLGPRVTALLLLL------GAVFAVLVGSTLFSPTLLLLLGAIAGFF 351
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 442619939  427 gVAISYESGSQYATELIPTCVRGQGVAAVHVAGFAASFLAPYI 469
Cdd:TIGR00895 352 -VNGGQSGLYALMALFYPTAIRATGVGWAIGIGRLGAIIGPIL 393
MFS_SLC22A17 cd17445
Solute carrier family 22, member 17 of the Major Facilitator Superfamily; Solute carrier ...
84-455 1.17e-12

Solute carrier family 22, member 17 of the Major Facilitator Superfamily; Solute carrier family 22, member 17 (SLC22A17) is also called 24p3 receptor (24p3R), lipocalin-2 receptor, or neutrophil gelatinase-associated lipocalin (NGAL) receptor (NGALR). It functions as a cell surface receptor for lipocalin-2 (LCN2), also called NGAL or 24p3, which plays a key role in iron homeostasis and transport. LCN2 is a secreted protein of the lipocalin family that induces apoptosis in some types of cells and inhibits bacterial growth by sequestration of the iron-laden bacterial siderophore. Over-expressions of NGAL and NGALR have been found to be correlated with unfavorable clinicopathologic features and poor prognosis of patients with hepatocellular carcinoma. SLC22A17 is a member of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341003 [Multi-domain]  Cd Length: 346  Bit Score: 69.42  E-value: 1.17e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939  84 NVTVSSKACEKWIYNYDFGYRS-MNTELNWVCDSAYKARIGQSLFFIGSVVGTLFYGLLSDKIGR----VPALILSNFCG 158
Cdd:cd17445    1 TQTGVRHCDAGWNYTGLPGLTNnIVTEWDLVCSRYWLVPLEQVCFILGFASGYLCLGYTADRLGRrrtlLLSLTLAVPFG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 159 FAGDFSTiftkSVATFTLCRFISGLAADTNFYLMYIIVLEYIRPSMRtLGLNMAVGLFYCLGLVFTPWLAVLVGHWQIYL 238
Cdd:cd17445   81 VLVAVAA----SPSLFMAMRFLLGAALAGVYLTLYLTRLELCDPPQR-LLVAMAGGLTMVGGHFLLLGLALGCGSWRVLQ 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 239 ACTSLPILLVVLYyfvvqesaqwlvtrndidgaivrlkrvakfnGCrvsqadfdefrrhcqmthemlggddkkqatlldm 318
Cdd:cd17445  156 GTITAPLSLFLCY-------------------------------GC---------------------------------- 170
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 319 frtPRMrKNTLILFFKSMV---ITLCYDAVSRNVEGMGISPFIMFSLSALAVLPSSVLLVLLQDRIGRKGMAsgsLLVGG 395
Cdd:cd17445  171 ---PGV-KNLLILGFTTFIahaISHCYQSFSDDVRGTPSTFYLSYLLSTGTAGLACLFLCATVDRFGRRGIL---LLAMT 243
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 396 LFTAAAGIAIAYQQHNHNAILLAcLTIAARFGVAISYESGSQYATELIPTCVRGQGVAAV 455
Cdd:cd17445  244 LTGIASLILLGLMDYLNDAAIKT-FSILGLFSSQAAASLSILFAAEVIPTVIRGSGLGLI 302
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
125-498 3.62e-12

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 67.99  E-value: 3.62e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 125 SLFFIGSVVGTLFYGLLSDKIGRVPALILSNFCGFAGDFSTIFTKSVATFTLCRFISGLAADTNFYLMYIIVLEYIRPSM 204
Cdd:cd17325   38 AAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEE 117
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 205 R--TLGL-NMAVGLFYCLGLVFTPWLAVLVGHWQIYLACTSLPILLVVLYYFVVQESAqwlvtrndidgaivrlkrvakf 281
Cdd:cd17325  118 RgrAMGIfSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEPR---------------------- 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 282 ngcrvsqadfdefrrhcQMTHEMLGGDDKKQATLLDMFRTPRMRKNTLILFFKSMVITLCYDAVS-RNVEGMGISPF--- 357
Cdd:cd17325  176 -----------------PPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPlYAAELGGLSPAqig 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 358 IMFSLSALAVLPSSVLLVLLQDRIGRKGMASGSLLVGGLFTAAAGIAiayqqhnHNAILLACLTIAARFGVAISYESGSQ 437
Cdd:cd17325  239 LLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLA-------TSFWLLLLLLALLGLGLGLVFPATLA 311
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 442619939 438 YATELIPTCVRGQGVAAVHVAGFAASFLAPYI--LWLGTFFKAAPSIILGVLFFAGSFVCLLL 498
Cdd:cd17325  312 LLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLggFLYDAFGFATPFLAAAALLLLAAVLFLLL 374
MFS_SLC22A15 cd17377
Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; ...
103-499 2.14e-11

Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 15 (SLC22A15) is also called fly-like putative transporter 1 (FLIPT1). It is expressed at the highest levels in the kidney and brain. It is a member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A15 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340935 [Multi-domain]  Cd Length: 353  Bit Score: 65.57  E-value: 2.14e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 103 YRSMNTELNWVCDSAYKARIGQSLFFIGSVVGTLFYGLLSDKIGRVPALILSNFCGFAGDFSTIFTKSVATFTLCRFISG 182
Cdd:cd17377   24 FTSIVSEWFLVGNAAYKVSLASSFFFAGVLIGVVSFGQLSDRFGRKPVYLTGLALDILFAYFNALAPSYEFFAVSRFLVG 103
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 183 LAADTNFYLMYIIVLEYIRPSMRTLGLNMAvGLFYCLGLVFTPWLAVLVGHWQIYLACTSLPILLVVLYYFVVQesaqwl 262
Cdd:cd17377  104 VMNGGMSLVAFVLLNECVGKSYWALAGSLG-GLFFAVGIAQYALLGYFIRSWRTLAVVVNLQGTLVFLLSLFIP------ 176
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 263 vtrndidgaivrlkrvakfngcrvsqadfdefrrhcqmthemlggddkkqatlldmfrtprmrKNTLILFFKSMVITLCY 342
Cdd:cd17377  177 ---------------------------------------------------------------GRTLILMYVWFVCSLVY 193
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 343 DAVSRNVEGMGISPFIMFSLSALAVLPS--SVLLVLLQDRIGRKGMASGSLLVGG---LFT----AAAGIAIAYQQHNHN 413
Cdd:cd17377  194 YGLTLNAGDLGGNIYLNLALSGLVELPAypLCIYLINQKWSGRRRTLAGFLFLGGiacLLVmfvpEKKDSGVFAVVNSTS 273
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 414 AILLACLTIAARFGVAISYESgsqyatELIPTCVRGQGVAAVHVAGFAASFLAPYILWLGTFFKAAPSIILGVLFFAGSF 493
Cdd:cd17377  274 LSLLGKLTISAAFNIVYIYTS------ELYPTVVRNAGLGVCSMFSRVGGIIAPFIPSLKSVQWSLPFIVFGASGLSAGL 347

                 ....*.
gi 442619939 494 VCLLLP 499
Cdd:cd17377  348 LSLLLP 353
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
125-501 2.14e-11

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 65.66  E-value: 2.14e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 125 SLFFIGSVVGTLFYGLLSDKIGRVPALILSNFCGFAGDFSTIFTKSVATFTLCRFISGLAADTNFYLMYIIVLEYIRPSM 204
Cdd:COG2271   52 SAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKE 131
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 205 RTLGL---NMAVGLFYCLGLVFTPWLAVLVGhWQIYLACTSLPILLVVLYYFvvqesaqWLVtrndidgaivrlkrvakf 281
Cdd:COG2271  132 RGRALgifNAGGPLGGALAPPLLGWLLAAFG-WRAAFLILGLPGLLLALLRF-------WLL------------------ 185
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 282 ngcrvsqadfdefrrhcqmthemlggddkkqatlldmfrtprmrknTLILFFKSMVITLCYD-AVSRNVEGMGISPF--- 357
Cdd:COG2271  186 ----------------------------------------------ALAYFLVYFALYGFLTwLPTYLVEVRGLSLAqag 219
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 358 IMFSLSALAVLPSSVLLVLLQDRIGRKGMAsgsLLVGGLFTAAAGIAIAYQQHNhNAILLACLTIAArFGVAISYESGSQ 437
Cdd:COG2271  220 LLLSLPFLAGIVGSLLGGWLSDRLGRRRKL---VLAIGLLLAALALLLLALLPS-PALAIALLFLAG-FGLGGAFGLLWA 294
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 442619939 438 YATELIPTCVRGQGVAAVHVAGFAASFLAPYIL-WL--GTFFKAAPSIILGVLFFAGSFVCLLLPET 501
Cdd:COG2271  295 LAAELFPKKARGTASGLVNTFGFLGGALGPLLVgYLldATGYQAAFLLLAALALLAALLALLLLRET 361
MFS_SLC22A23 cd17444
Solute carrier family 22, member 23 of the Major Facilitator Superfamily; Solute carrier ...
88-254 2.19e-11

Solute carrier family 22, member 23 of the Major Facilitator Superfamily; Solute carrier family 22, member 23 (SLC22A23) is an orphan member of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). It is abundantly expressed in brain and is also found in liver. Single-nucleotide polymorphisms in SLC22A23 are associated with inflammatory bowel disease (IBD) in a Canadian white population. SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A23 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341002 [Multi-domain]  Cd Length: 364  Bit Score: 65.64  E-value: 2.19e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939  88 SSKACEKWIYNYDFGYR-SMNTELNWVCDSAYKARIGQSLFFIGSVVGTLFYGLLSDKIGRVPALILSNFCGFAGDFSTI 166
Cdd:cd17444    5 SSCQCTERDYRIRAGLVqNIVSKWDLVCDSSWKVHIAKFSLLVGLIFGYLITGCLADWFGRRPVLLFSVVFILIFGLTVA 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 167 FTKSVATFTLCRFISGLAADTNFYLMYIIVLEYIRPSMRTLgLNMAVGLFYCLGLVFTPWLAVLVGHWQIYLACTSLPIL 246
Cdd:cd17444   85 LSVNVTMFSTLRFFEGFCLAGIILSLYALRIELCPPGHRFM-ITMVASFIAMAGQFLMPGLAALCRDWQVLQAVIICPFL 163

                 ....*...
gi 442619939 247 LVVLYYFV 254
Cdd:cd17444  164 LMLSYWCI 171
MFS_SLC22A7_OAT2 cd17447
Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major ...
95-250 4.94e-11

Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 7 (SLC22A7), also called organic anion transporter 2 (OAT2) mediates sodium-independent transport of a variety of organic anions including prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha-ketoglutarate. It also plays a role in renal uric acid uptake from blood as a first step of tubular secretion. OAT2 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS)of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341005 [Multi-domain]  Cd Length: 341  Bit Score: 64.37  E-value: 4.94e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939  95 WIYNYDFGYRSMNTELNWVCDSAYKARIGQSLFFIGSVVGTLFYGLLSDKIGRVPALILSNFCGFAGDFSTIFTKSVATF 174
Cdd:cd17447   12 WVYDHSTFSSTIATEWDLVCDRKGLNQATATFFFAGVTMGAVAFGYLSDRFGRKRMLLVAYVLSLVFGLASAFSVSYVMF 91
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 442619939 175 TLCRFISGLAADTNFYLMYIIVLEYIRPSMRTLGLNMaVGLFYCLGLVFTPWLAVLVGHWQIYLACTSLPILLVVL 250
Cdd:cd17447   92 AITRTLTGFALTGFSIISMVLCVEWVDIEHRTVAGVL-ISLFWTVGNMLLALVAYLIRDWRWLILAVTLPCAPGII 166
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
125-258 7.89e-11

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 64.13  E-value: 7.89e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 125 SLFFIGSVVGTLFYGLLSDKIGRVPALILSNFCGFAGDFSTIFTKSVATFTLCRFISGLA--ADTNFYLMYI--IVLEYI 200
Cdd:cd17315   41 SSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGRFLLGLGvgLASVLVPLYIseIAPAKI 120
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 442619939 201 RPSMRTL-GLNMAVGLF--YCLGLVFTPWLAVLvghWQIYLACTSLPILLVVLYYFVVQES 258
Cdd:cd17315  121 RGALGTLnQLMITFGILlaYLLGLALSLSPPGW---WRLMFALAAVPALLQLLLMFFLPES 178
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
122-496 9.02e-11

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 63.98  E-value: 9.02e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 122 IGQSLFFIGSVVGTLFYGLLSDKIGRVPALILSNFCGFAGDFSTIFTKSVATFTLCRFISGLAADTNFYLMYIIVLEYIR 201
Cdd:cd06174   35 LLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFP 114
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 202 PSMRTLGL---NMAVGLFYCLGLVFTPWLAV-LVGHWQIYLACTSLPILLVVLYYFVVQESAQWLVTRNDIDGAIVRLKR 277
Cdd:cd06174  115 ERERGRALgllQAFGSVGGILGPLLGGILASsLGFGWRAVFLIAAALALLAAILLLLVVPDPPESARAKNEEASSKSVLK 194
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 278 vakfngcrvsqadfdefrrhcqmthemlggddkkqaTLLDMFRTPRMRKNTLILFFKSMV----ITLCYDAVSRNVEGMG 353
Cdd:cd06174  195 ------------------------------------LLKRVLKNPGLWLLLLAIFLVNLAyysfSTLLPLFLLDLGGLSV 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 354 ISPFIMFSLSALAVLPSSVLLVLLQDR-IGRKGMASGSLLVGGLFTAAAGIAIayqqhnhNAILLACLTIAARFGVAISY 432
Cdd:cd06174  239 AVAGLLLSLFGLAGALGSLLLGLLSDRlIGRKPLLLIGLLLMALGLALLLLAP-------SLLLLLLLLLLLGFGLGGLL 311
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 442619939 433 ESGSQYATELIPTCVRGQGVAAVHVAGFAASFLAPYI---LWLGTFFKAAPSIILGVLFFAGSFVCL 496
Cdd:cd06174  312 PLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLagfLLAATFGLTGAFLVLAVLLLLAAILLL 378
MFS_SLC22A17_like cd17373
Solute carrier family 22, member 17 and similar proteins of the Major Facilitator Superfamily; ...
111-252 2.41e-10

Solute carrier family 22, member 17 and similar proteins of the Major Facilitator Superfamily; This group is composed of Solute carrier family 22, members 17, 23, and 31. They are members of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). SLC22A17 functions as a cell surface receptor for lipocalin-2 (LCN2), also called NGAL or 24p3, which plays a key role in iron homeostasis and transport. SLC22A23 and SLC22A31 are orphan members of the SLC22 family. SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22A17-like group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340931 [Multi-domain]  Cd Length: 348  Bit Score: 62.15  E-value: 2.41e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 111 NWVCDSAYKARIGQSLFFIGSVVGTLFYGLLSDKIGRVPALILSnfCGFAGDF--STIFTKSVATFTLCRFISGLAADTN 188
Cdd:cd17373   18 DLVCDNGWKVHLEQFSLLLGLIFGYLILGCIADRFGRRPVLLFS--LILILIFglTVALAVSVTMFSTLRFLEGFCLAGI 95
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 442619939 189 FYLMYIIVLEYIRPSMRtLGLNMAVGLFYCLGLVFTPWLAVLVGHWQIYLACTSLPILLVVLYY 252
Cdd:cd17373   96 ILTLYLLRLELCDPGKR-LMITMVASLVAVAGQFLMPGLAALCRDWRVLQALIICPFLLMLLYW 158
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
125-501 4.40e-10

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 61.93  E-value: 4.40e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 125 SLFFIGSVVGTLFYGLLSDKIGRVPALILSnFCGFA-GDFSTIFTKSVATFTLCRFISGLAADTNFYLMYIIVLEYIRPS 203
Cdd:cd17371   41 TVTLAGGAIGGILGGILADRFGRVRVLVIT-ILLFAvFTLLCGFAQNYWQLLILRALAGLGFGGEWAAGAALMAEYVPAR 119
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 204 MR-----------TLGLNMAVGLFYCLGLVFTPWLAvlvghWQIYLACTSLPILLVVLYYFVVQESAQWlvtrndidgAI 272
Cdd:cd17371  120 HRgkalgyvqsgwAVGWLLATLLAALLFPLLPPEIA-----WRVLFLLGALPALLVLFIRRFVKEPPQW---------QA 185
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 273 VRLKRVAkfngcrvsqadfdefrrhcqmthemlGGDDKKQATLLDmfrtPRMRKNTLILFFKSMVITLCYDAVSR----- 347
Cdd:cd17371  186 ARAARRH--------------------------FADRPSLRELFS----PPLLRTTLLASLLATGALGGYYGITTwlpsy 235
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 348 -------NVEGMGISPFIMfslsALAVLPSSVLLVLLQDRIGRKGMASgsllvggLFTAAAGIAI-AYQQHNHNAILLAC 419
Cdd:cd17371  236 ltgerglSFEGSAGYLVVT----ILGGFLGYLAGGFLADRIGRRNNFA-------LFALGSAISIlLYFFLPLSPTLILI 304
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 420 LTIAARFGVAISYESGSQYATELIPTCVRGQGVAAVHVAGFAASFLAPY-ILWLGTFFKAAPSIILGVL--FFAGSFVCL 496
Cdd:cd17371  305 LGFPLGFFASGPFSGMGAYLTELFPTAVRATAQGFCYNVGRIIGALFPFlVGFLATSGSLGTAIAVFAAvyYIAGLVLAL 384

                 ....*
gi 442619939 497 LLPET 501
Cdd:cd17371  385 LLPET 389
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
125-498 3.29e-09

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 59.12  E-value: 3.29e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 125 SLFFIGSVVGTLFYGLLSDKIGRVPALILSNFCGFAGDFSTIFTKSVATFTLCRFISGLAADTNFYLMYIIVLEYIRPSM 204
Cdd:COG2223   47 AIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDR 126
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 205 RTLGLNMAVGLF---YCLGLVFTPWLAVLVGhWQIYLACTSLPILLVVLYYfvvqesaqWLVTRNDIDGAIvrlkrvakf 281
Cdd:COG2223  127 RGLALGLAAGGGnlgAAVAAFLAPLLIAAFG-WRNAFLILGILLLVVAVLA--------WLFLRDPPAGAA--------- 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 282 ngcRVSQADFdefrrhcqmthemlggddkkqATLLDMFRTPRmrknTLILFFKSMVITLCYDAVSRN-----VEGMGISP 356
Cdd:COG2223  189 ---AAAKASL---------------------RDQLEALRDPR----FWLLSLLYFGTFGSFIGFSSWlppylVDQFGLSA 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 357 ---FIMFSLSALAVLPSSVLLVLLQDRIGRKgmasGSLLVGGLFTAAAGIAIAYQQHNHNAILLACLTIAARFGVAISye 433
Cdd:COG2223  241 ataGLLAALFALLGALGRPLGGWLSDRIGGR----RVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNG-- 314
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 442619939 434 SGSQYATELIPTCVRGQGVAAVHVAGFAASFLAPYIlwLGTFFKAAPSIILGVLFFAG-SFVCLLL 498
Cdd:COG2223  315 AVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLL--FGALLDATGSYTAAFLVFAVlALVALVL 378
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
125-498 4.26e-09

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 58.74  E-value: 4.26e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 125 SLFFIGSVVGTLFYGLLSDKIGRVPALILSNFCGFAGDFSTIFTKSVATFTLCRFISGLAADTNFYLMYIIVLEYIRP-- 202
Cdd:cd17320   41 SAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGae 120
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 203 SMRTLG-LNMAVGLFYCLGLVFTPWLAVLVGHWQIYLACTSLPILLVVLYYFVVQESAQwlvtrndIDGAIVRLKRVakf 281
Cdd:cd17320  121 LAKIFSlLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLLVLLFLPETLP-------EEKRKPLLSSL--- 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 282 ngcrvsqadFDEFRRhcqmthemlggddkkqatlldMFRTPRMRKNTLILFFkSMVITLCYDAVSRNV--EGMGISPF-- 357
Cdd:cd17320  191 ---------LRAYKR---------------------VLKNRRFLGYALALGL-SFAGLFAYLAAAPFIyiEQLGLSPAqf 239
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 358 -IMFSLSALAVLPSSVLLVLLQDRIGRK---GMASGSLLVGGLFTAAAGIAiayqQHNHNAILLACLTIAArFGVAISYE 433
Cdd:cd17320  240 gLLFALNAIALILGSLLNGRLVRRFGPRrllRLGLLLLLAAALVLLLAALL----GGLSLWPLVAPLFLIF-FGFGLIFP 314
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 442619939 434 SGSQYATELIPTCvrgQGVAAVhVAGFAASFLAPYILWLGTFFKAAPSIILGVLFFAGSFVCLLL 498
Cdd:cd17320  315 NATSLALEPFPHV---AGTASA-LLGFLQFLIGALAGALVGLLPNGTALPMGLLILVLGLLALLL 375
MFS_GLUT_Class2 cd17432
Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ...
125-507 1.71e-08

Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT5, also called Solute carrier family 2, facilitated glucose transporter member 5 (SLC2A5), is a well-established fructose transporter found in the small intestine. GLUT7 (or SLC2A7) is a high-affinity glucose and fructose transporter expressed in the small intestine and colon. GLUT9 (or SLC2A9) transports urate and fructose, and is most strongly expressed in the basolateral membranes of proximal renal tubular cells, liver and placenta. It may play a role in urate reabsorption by proximal tubules. GLUT11 (or SLC2A11) is a facilitative glucose transporter expressed in heart and skeletal muscle. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340990 [Multi-domain]  Cd Length: 452  Bit Score: 56.86  E-value: 1.71e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 125 SLFFIGSVVGTLFYGLLSDKIGRVPALILSNFCGFAGDFSTIFTKSVATFTLC---RFISGLAA--DTNFYLMYI--IVL 197
Cdd:cd17432   57 SIFPLGGLFGSLLVGPLVIRLGRKGTLLLNNIFAIVAAILMGLSKIAKSFEMIivgRFLVGINAgiSLNVVPMYLgeSAP 136
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 198 EYIRPSmrtlgLNMAVGLFYCLGLVftpwLAVLVG---------HWQIYLACTSLP--ILLVVLYYFvvQESAQW-LVTR 265
Cdd:cd17432  137 KNLRGA-----VGLVPAIFITLGIL----LGQVLGlrellgneeGWPLLLALTGVPalLQLLTLPFF--PESPRYlLIEK 205
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 266 NDIDGAIVRLKRvakFNGCRVSQADFDEfrrhcqMTHEMLGGDDKKQATLLDMFRTPRMRKNTLILFFKSMVITLC-YDA 344
Cdd:cd17432  206 GDEEAARKALQR---LRGKEDVDDEMEE------MLEEQRAEKGVGTVSVLELFRDRSVRWQLISIIVLMAGQQLCgINA 276
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 345 V---------SRNVE---------GMGISPFIMFSLSALAVlpssvllvllqDRIGRKgmasgSLLVGG---LFTAAAGI 403
Cdd:cd17432  277 IyfyadsiflEAGIPedkiqyvtvGTGACEVLATITCVLVI-----------ERLGRR-----PLLIGGfglMAVWCAVL 340
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 404 AIAYQQHNHNAILLAcLTIAARFGVAISYESGSQYATELIPTCVRGQGV--AAVHVAG-------FAASFLAPYIL-WLG 473
Cdd:cd17432  341 TVALSLQNTVSWMPY-LSIVCIFAYIASFGIGPAGVPFILTTEIFDQSSrpAAFMVAGslnwlsnFLVGLLFPFIQeGLG 419
                        410       420       430
                 ....*....|....*....|....*....|....*
gi 442619939 474 TF-FkaapSIILGVLFFAGSFVCLLLPETLNRSLP 507
Cdd:cd17432  420 AYcF----LVFAVICLLTAIYIFFVLPETKGKTFL 450
MFS_XylE_like cd17359
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...
125-266 3.54e-08

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340917 [Multi-domain]  Cd Length: 383  Bit Score: 55.65  E-value: 3.54e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 125 SLFFIGSVVGTLFYGLLSDKIGRVPALILSNFCGFAGDFSTIFTKSVATFTLCRFISGLA--ADTNFYLMYI--IVLEYI 200
Cdd:cd17359   43 SSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARIIGGLAvgGASALVPMYIaeVAPAEI 122
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 442619939 201 RPSMRTLG-LNMAVGLF--YCLGLVFTPWLAVLVGH---WQIYLACTSLPILLVVLYYFVVQESAQWLVTRN 266
Cdd:cd17359  123 RGRLVSLNqLMIVFGQLlaYIVNYLIANAGGADWLGaegWRWMLGLEAIPAILFLLGMLFIPESPRWLVSKG 194
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
125-250 3.15e-07

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 52.60  E-value: 3.15e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 125 SLFFIGSVVGTLFYGLLSDKIGRVPALILSNFCGFAGDFSTIFTKSVATFTLCRFISGLAADTNFYLMYIIVLEYIRPSM 204
Cdd:cd17489   38 GLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSR 117
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 442619939 205 RTLGLNMAvGLFYCLGLVFTPWLAVLVGHWQIY--LACTSLPILLVVL 250
Cdd:cd17489  118 RGEGIGYY-GLATTLAMALGPALGLFLYQHLGFavLFIVAAVLALLAL 164
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
125-260 5.22e-07

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 52.18  E-value: 5.22e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 125 SLFFIGSVVGTLFYGLLSDKIGR--VPALILSNFCGFAGDFSTIFTKSVATFTLCRFISGLAADTNFYLMYIIVLEYIRP 202
Cdd:COG2271  223 SLPFLAGIVGSLLGGWLSDRLGRrrKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPK 302
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 442619939 203 SMRTLG---LNMAVGLFYCLGLVFTPWLAVLVGHWQIYLACTSLPILLVVLYYFVVQESAQ 260
Cdd:COG2271  303 KARGTAsglVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRETRK 363
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
116-185 6.42e-07

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 51.81  E-value: 6.42e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 116 SAYKARIGQSLFFIGSVVGTLFYGLLSDKIGRVPALILSNFCGFAGDFSTIFTKSVATFTLCRFISGLAA 185
Cdd:cd17323   32 SEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRFLQGFFG 101
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
125-263 3.36e-06

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 49.04  E-value: 3.36e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 125 SLFFIGSVVGTLFYGLLSDKIGRVPALILSNFCGFAGDFSTIFTKSVATFTLCRFISGLAADTNFYLMYIIVLEYIRPSM 204
Cdd:COG0477   56 SAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARE 135
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 442619939 205 RTLGLNMaVGLFYCLGLVFTPWLA-VLVGH--WQIYLACTSLPILLVVLYYFVVQESAQWLV 263
Cdd:COG0477  136 RGRALGL-WGAAIGLGLALGPLLGgLLVAAlgWRWIFLINAPLGLLALVLRLRLPESRGLLL 196
efflux_Bcr_CflA TIGR00710
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...
125-258 4.16e-06

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.


Pssm-ID: 273229 [Multi-domain]  Cd Length: 385  Bit Score: 49.30  E-value: 4.16e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939  125 SLFFIGSVVGTLFYGLLSDKIGRVPALILSNFCGFAGDFSTIFTKSVATFTLCRFISGLAADTNFYLMYIIVLEYI--RP 202
Cdd:TIGR00710  47 TLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVLRFVQAFGASAGSVISQALVRDIYpgEE 126
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 442619939  203 SMRTLGLNMAVglfyclgLVFTPWLAVLVG-------HWQIYLACTSL-PILLVVLYYFVVQES 258
Cdd:TIGR00710 127 LSRIYSILMPV-------LALAPAVAPLLGgyilvwlSWHAIFAFLSLaGILLSALIFFILPET 183
synapt_SV2 TIGR01299
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ...
125-282 1.05e-05

synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.


Pssm-ID: 130366 [Multi-domain]  Cd Length: 742  Bit Score: 48.43  E-value: 1.05e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939  125 SLFFIGSVVGTLFYGLLSDKIGRVPALILS-NFCGFAGDFSTiFTKSVATFTLCRFISGLAADTNFYLMYIIVLEYIRPS 203
Cdd:TIGR01299 209 LIVYLGMMVGAFFWGGLADKLGRKQCLLIClSVNGFFAFFSS-FVQGYGFFLFCRLLSGFGIGGAIPIVFSYFAEFLAQE 287
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939  204 MRTLGLNMaVGLFYCLGLVFTPWLA-VLVGH---------------WQIYLACTSLPILLVVLYYFVVQESAQWLVTRND 267
Cdd:TIGR01299 288 KRGEHLSW-LCMFWMIGGIYAAAMAwAIIPHygwsfqmgsayqfhsWRVFVIVCAFPCVFAIGALTFMPESPRFFLENGK 366
                         170
                  ....*....|....*
gi 442619939  268 IDGAIVRLKRVAKFN 282
Cdd:TIGR01299 367 HDEAWMILKLIHDTN 381
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
116-254 1.11e-05

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 47.98  E-value: 1.11e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 116 SAYKARIGQSLFFIGSVVGTLFYGLLSDKIGRVPALILSNFCG--FAGDFSTIFTKSVATFTLCRFISGLAADTNFYLMY 193
Cdd:cd17316  211 SPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSgiLALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALY 290
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 442619939 194 IIVLEYIRPSMRTLGLNMAVGLFYCLGLVFTPWLAVLVGHWQIYLACTSLPILLVVLYYFV 254
Cdd:cd17316  291 AYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVALIV 351
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
125-253 1.46e-05

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 47.54  E-value: 1.46e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 125 SLFFIGSVVGTLFYGLLSDKIGRVPALILSNFCGFAGDFSTIFTKSVATFTLCRFISGLAADTNFYLMYIIVLEYIRPSM 204
Cdd:cd17324   41 SAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEK 120
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 442619939 205 RT--LGLNMA---VGLFycLGLVFTPWLAVLVGhWQIY---LACTSLPILLVVLYYF 253
Cdd:cd17324  121 RGraIGLVFSgltLGLV--LGRPLGGLLGQLLG-WRAAflaIAVLALLAALLLWRLL 174
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
124-498 1.84e-05

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 47.16  E-value: 1.84e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 124 QSLFFIGSVVGTLFYGLLSDKIGRVPALILSNFCGFAGDFSTIFTKSVATFTLCRFISGLAA---DT--NfylMYIIVLE 198
Cdd:COG0738   49 LFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLGLgllDVaaN---PYVAALG 125
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 199 yirPSMRTLGLNMAvGLFYCLGLVFTPWLAVLV------GHWQI-YLACTSLPILLVVLYYFVvqesaqwlvtrndidga 271
Cdd:COG0738  126 ---PETAASRLNLL-HAFFSLGALLGPLLGGLLillglsLSWHLpYLILAVLLLLLALLFLRS----------------- 184
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 272 ivrlkrvaKFNGCRVSQADfdefrrhcqmthemlggDDKKQATLLDMFRTPRMRKNTLILFFKSMVITLCYDAVSR-NVE 350
Cdd:COG0738  185 --------KLPEIEEEEEE-----------------AAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLyLKD 239
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 351 GMGISPFI---MFSLSALAVLPSSVLLVLLQDRIGRKGMasgslLVGGLFTAAAGIAIAYQQHNHNAILLACLTIAarFG 427
Cdd:COG0738  240 VLGLSEATaalGLSLFWGGMTIGRFLGGFLLKRFGPVRL-----LRLSALLAAVGLLLALLAPGPWLALIGLALVG--LG 312
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 442619939 428 VAISYESGSQYATELIPTcVRGQGVAAVHVAGFAASFLAPYIL-WLGTFFKAAPSIILGVLFFAGSFVCLLL 498
Cdd:COG0738  313 LSLMFPTIFSLALDGLGK-RTAAAVSAVLIMGIVGGAIGPPLIgFLADAFGLRAAFLVPLVCYLLILLLALA 383
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
138-254 2.06e-05

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 47.21  E-value: 2.06e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 138 YGLLSDKIGRVPALILSNFCGFAGDFSTIFTKSVATFTLCRFISGLAADTNfyLMYIIVLEYIRPSMRTL---GLNMAVG 214
Cdd:cd17472   52 FGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGSGAISS--VVMALLADLTREENRTKamaLIGASIG 129
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 442619939 215 LFYCLGLVFTPWLAVLVGHWQIYLACTSLPIL-LVVLYYFV 254
Cdd:cd17472  130 IAFAISMVLGPLLAAHLGVSGLFLITAILSLVsLLILLFFV 170
2_A_01_02 TIGR00880
Multidrug resistance protein;
125-258 2.53e-05

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 44.18  E-value: 2.53e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939  125 SLFFIGSVVGTLFYGLLS----DKIGRVPALILSNFCGFAGDFSTIFTKSVATFTLCRFISGLAADTNFYLMYIIVLEYI 200
Cdd:TIGR00880   1 GLLLAGYALGQLIYSPLSglltDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIY 80
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 442619939  201 RPSMRTLGLNMAVGLFYC---LGLVFTPWLAVLVGHWQIYLACTSLPILLVVLYYFVVQES 258
Cdd:TIGR00880  81 PPEERGVALGLMSAGIALgplLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLPET 141
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
120-250 5.30e-05

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 45.62  E-value: 5.30e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 120 ARIGQSLFFIGSVVGTLFYGLLSDKIGRVPALILSNFCGFAGDFSTIFTKSVATFTLCrFISGLAADTNFYLMYIIVLEY 199
Cdd:cd17478  232 AGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWSYILL-VLAGFLLFASFPVTVVLAQEL 310
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 200 IRPSMrtlglNMAVGLFycLGLVFTP--WLAVLVG----HWQI---YLACTSLPILLVVL 250
Cdd:cd17478  311 LPGNV-----GLASGLM--MGLSFGLggIGAPVLGaladAFGLesvLLILALLPLLGALL 363
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
125-255 6.96e-05

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 45.26  E-value: 6.96e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 125 SLFFIGSVVGTLFYGLLSDKIGRVPALILSNFCGFAGDFSTIFTKSVATFTLCRFISGLAADTNFYLMYIIVLEYIRPSM 204
Cdd:cd17325  242 GAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEG 321
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 442619939 205 RtlGLNMAV-GLFYCLGLVFTPWLAVLV----GHWQIYLACTSLPILLVVLYYFVV 255
Cdd:cd17325  322 R--GTAMGLfNTAFSLGMVLGPLLGGFLydafGFATPFLAAAALLLLAAVLFLLLR 375
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
125-250 8.77e-05

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 44.86  E-value: 8.77e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 125 SLFFIGSVVGTLFYGLLSDKIGRVPALILSNFCGFAGDFSTIFTKSVATFTLCRFISGLAADTNFYLMYIIVLEYIRPSM 204
Cdd:cd17477   38 SAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNEN 117
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 442619939 205 RtlGLNMAV-GLFYCLGLVFTPWLAVLVGH--WQIYL---ACTSLPILLVVL 250
Cdd:cd17477  118 R--GRVLGLySTVLGLGFALGPLLLALVGTagALPFLiaaVLLLLALVPLLL 167
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
124-250 1.13e-04

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 44.62  E-value: 1.13e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 124 QSLFFIGSVVGTLFYGLLSDKIGRVPALILSNFCGFAGDFSTIFTKSVATFTLCRFISGLAADTNFYLMYIIVLEYIRPS 203
Cdd:cd17333   37 FSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGLGAGILDTGANTFVGALFEES 116
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 442619939 204 MRTLgLNMAVGlFYCLGLVFTPWLAVL----VGHWQIYLACTSLPILLVVL 250
Cdd:cd17333  117 SATR-LNVLHG-FFGLGALIGPLIATSlltsELSWSWAYLIIGLIYLLLAI 165
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
106-255 1.23e-04

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 44.48  E-value: 1.23e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 106 MNTELNWvcdSAYKARIGQSLFFIGSVVGTLFYGLLSDKIG-----RVPALILSNFCGFAGdfstiFTKSVATFTLCRFI 180
Cdd:cd17319   29 IMKDLGL---SPTQYGLIASAFFLGYALFQVPGGWLLDRFGarkvlAVSMLLWSLFTALTG-----FATSLTSLYVLRFL 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 181 SGLAADTNFYLMYIIVLEYIRPSMRTLglnmAVGLFYC---LGLVFTP----WLAVLVGhWQ-IYLACTSLPILLVVLYY 252
Cdd:cd17319  101 LGVAEAGFFPGAIKALAEWFPARERGR----ATGLFNSgapLGAAIGPplsgWLLLLFG-WRwAFIIEGLLGLLLAVLWW 175

                 ...
gi 442619939 253 FVV 255
Cdd:cd17319  176 FYL 178
MFS_SVOP_like cd17372
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ...
125-253 1.26e-04

Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340930 [Multi-domain]  Cd Length: 367  Bit Score: 44.45  E-value: 1.26e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 125 SLFFIGSVVGTLFYGLLSDKIGRVPALILSNFCGFAGDFSTIFTKSVATFTLCRFISGLAADTNFYLMyIIVLEYIRPSM 204
Cdd:cd17372   41 SVVFAGMMIGSYLWGIVSDKYGRRKGLIISALWTFYAGFLSAFAPNYMWLIILRCLVGLGLGGGPQLA-SWYLEFLPAKS 119
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 442619939 205 RTLGLnMAVGLFYCLGLVFTPWLAVLVG---HWQIYLACTSLPILLVVLYYF 253
Cdd:cd17372  120 RGTWM-VLFSVFWTVGTIFEASLAWLVMprlGWRWLLAFSSVPSSLLLVFYR 170
PRK11043 PRK11043
Bcr/CflA family multidrug efflux MFS transporter;
125-185 1.27e-04

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182924 [Multi-domain]  Cd Length: 401  Bit Score: 44.50  E-value: 1.27e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 442619939 125 SLFFIGSVVGTLFYGLLSDKIGRVPALI--LSNFCgfAGDFSTIFTKSVATFTLCRFISGLAA 185
Cdd:PRK11043  48 SLFLAGFALGQLLWGPLSDRYGRKPVLLagLSLFA--LGSLGMLWVESAAQLLVLRFVQAVGV 108
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
125-250 1.36e-04

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 44.50  E-value: 1.36e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 125 SLFFIGSVVGTLFYGLLSDKIGRVPALILSnfCGFAGDFS--TIFTKSVATFTLCRFISGL---AADTNfylMYIIVLEY 199
Cdd:cd17365   41 SAALFGMAIGALLAGPLADRFGRKRVLLVS--VALFGLFTllTAFAQSVLQLALLRFLTGLglgAAMPN---AITLVSEY 115
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 442619939 200 IRPSMRtlglNMAVGLFYC---LGLVFTPWLA-VLVGH--WQI-YLACTSLPILLVVL 250
Cdd:cd17365  116 APARRR----SLAVTLMFCgypLGAALGGFLAaALIPAfgWRSvFLLGGVPPLILLPL 169
MFS_SV2B cd17438
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ...
113-282 1.52e-04

Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340996 [Multi-domain]  Cd Length: 477  Bit Score: 44.53  E-value: 1.52e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 113 VCDSAYKARIGQSLFFIGSVVGTLFYGLLSDKIGRVPALILSNFCGFAGDFSTIFTKSVATFTLCRFISGLAADTNFYLM 192
Cdd:cd17438   29 MCLSSSNKGMLGLIVYLGMMAGAFIWGGLADKLGRKRCLIISLAINASFAFLSSFVQGYGAFLFCRLISGFGIGGSLPIV 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 193 YIIVLEYIRPSMRTLGLNMaVGLFYCLGLVFTPWLA-VLVGH---------------WQIYLACTSLPILLVVLYYFVVQ 256
Cdd:cd17438  109 FAYFSEFLAREKRGEHLSW-LCMFWMIGGLYASAMAwSIIPHygwgfsmgtnyhfhsWRVFVIICALPCIASIIALKFMP 187
                        170       180
                 ....*....|....*....|....*.
gi 442619939 257 ESAQWLVTRNDIDGAIVRLKRVAKFN 282
Cdd:cd17438  188 ESPRFLLEMGKHDEAWMILKNIHDTN 213
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
125-228 1.57e-04

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 44.51  E-value: 1.57e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 125 SLFFIGSVVGTLFYGLLSDKIGRVPALILSNFCGFAGDFSTIF--TKSVATFTLCRFISGLAADTNFYLMYII---VLEY 199
Cdd:COG2211  271 ALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFlgPGNLWLLLVLAALAGIGLGAILVLPWAMladVVDY 350
                         90       100       110
                 ....*....|....*....|....*....|..
gi 442619939 200 --IRPSMRTLGLNMAV-GLFYCLGLVFTPWLA 228
Cdd:COG2211  351 deWKTGRRREGLYFGIfTFAIKLGQALAGALA 382
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
129-228 2.54e-04

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 43.77  E-value: 2.54e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 129 IGSVVGTLFYGLLSDKIGRVPALILSNFCGFAGDFSTIFTKSVATFTLCRFISGLAADTNFyLMYIIVLEYIRPSMRTLG 208
Cdd:cd06179   43 LAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAGTAKSVNMLIGGQALIGIGAGTQG-LGAAVASELVPNKYRGLV 121
                         90       100
                 ....*....|....*....|...
gi 442619939 209 L---NMAVGLFYCLGLVFTPWLA 228
Cdd:cd06179  122 QgvvNLVASPGSALGPLIAGALV 144
TRI12 pfam06609
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific ...
122-253 2.73e-04

Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.


Pssm-ID: 115279 [Multi-domain]  Cd Length: 598  Bit Score: 43.89  E-value: 2.73e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939  122 IGQS--------LFFIGSVVGTLFYGLLSDKIGRVPALILSNFCGFAGDF----STIFTKSVATFTLCRFISGLAADTNF 189
Cdd:pfam06609  74 IGQSenqglfstLWTMGQAVSILMMGRLTDRFGRRPFVIATHIIGLVGAIvgctANKFNTLLAAMTLLGVAAGPAGASPL 153
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 442619939  190 YlmyiiVLEYIRPSMRTLGL---NMAVGLFYCLGLVFTPWLAVLvGHWQ----IYLACTSLPILLVVLYYF 253
Cdd:pfam06609 154 F-----IGELMSNKTKFLGLlivSAPTIAMNGAGPYFGQRLAIQ-GNWRwifyIYIIMSAIAVLLIIIWYH 218
MFS_SV2A cd17439
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; ...
126-282 3.98e-04

Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. It is unclear how SV2A is involved in correct SV function, but it has been suggested to either act as a transporter or a regulator of exocytosis by mediating Ca2+ dynamics. SV2A has been identified as the molecular target of the antiepileptic drug levetiracetam (LEV). Its expression is decreased in patients with epilepsy and in epileptic animal models. SV2A belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340997 [Multi-domain]  Cd Length: 478  Bit Score: 43.10  E-value: 3.98e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 126 LFFIGSVVGTLFYGLLSDKIGRVPALILSNFCGFAGDFSTIFTKSVATFTLCRFISGLAADTNFYLMYIIVLEYIRPSMR 205
Cdd:cd17439   42 IVYLGMMVGAFLWGGLADRIGRRQCLLISLSVNSVFAFFSSFVQGYGTFLFCRLLSGVGIGGSIPIVFSYFSEFLAQEKR 121
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 206 TLGLNMaVGLFYCLGLVFTPWLA-VLVGH---------------WQIYLACTSLPILLVVLYYFVVQESAQWLVTRNDID 269
Cdd:cd17439  122 GEHLSW-LCMFWMIGGIYASAMAwAIIPHygwsfqmgsayqfhsWRVFVLVCAFPSVFAIGALTTMPESPRFFLENGKHD 200
                        170
                 ....*....|...
gi 442619939 270 GAIVRLKRVAKFN 282
Cdd:cd17439  201 EAWMVLKQVHDTN 213
MFS_SV2C cd17440
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; ...
125-282 4.25e-04

Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2C exhibits enriched expression in several basal ganglia nuclei, and has been found to be involved in normal operation of the basal ganglia network and could be also be involved in system adaptation in basal ganglia pathological conditions. SV2C belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340998 [Multi-domain]  Cd Length: 479  Bit Score: 42.98  E-value: 4.25e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 125 SLFFIGSVVGTLFYGLLSDKIGRVPALILS-NFCGFAGdFSTIFTKSVATFTLCRFISGL----AADTNF-YLMYIIVLE 198
Cdd:cd17440   41 SIVYLGMMVGAFFWGGLADKVGRRQSLLICmSVNGFFA-FLSSFVQGYGLFLFCRLLSGFgiggAVPTVFsYFAEVLARE 119
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 199 YIRPSMRTLGLNMAVGLFYC----------LGLVFTPWLAVLVGHWQIYLACTSLPILLVVLYYFVVQESAQWLVTRNDI 268
Cdd:cd17440  120 KRGEHLSWLCMFWMIGGIYAsamawaiiphYGWSFSMGSAYQFHSWRVFVIVCALPCVSSVVALTFMPESPRFLLEVGKH 199
                        170
                 ....*....|....
gi 442619939 269 DGAIVRLKRVAKFN 282
Cdd:cd17440  200 DEAWMILKQIHDTN 213
PRK12307 PRK12307
MFS transporter;
128-261 4.34e-04

MFS transporter;


Pssm-ID: 237051 [Multi-domain]  Cd Length: 426  Bit Score: 42.99  E-value: 4.34e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 128 FIGSVVGTLFYGLLSDKIGRVPALILSNFCGFAGDFSTIFTKSVATFTLCRFISGLAADTNFYLMYIIVLEYIRPSMRTL 207
Cdd:PRK12307  63 FIGRPFGGALFGLLADKFGRKPLMMWSIVAYSVGTGLSGLASGVIMLTLSRFIVGMGMAGEYACASTYAVESWPKHLKSK 142
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 442619939 208 GLNMAVGLFYCLGLV---FTPWLAVLVGhWQIYLACTSLPILLVVLYYFVVQESAQW 261
Cdd:PRK12307 143 ASAFLVSGFGIGNIIaayFMPSFAEAYG-WRAAFFVGLLPVLLVIYIRARAPESKEW 198
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
125-253 6.50e-04

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 42.22  E-value: 6.50e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 125 SLFFIGSVVGTLFYGLLSDKIGRVPALILSNFCGFAGDFSTIFTKSVATFTLCRFISGLAADTNFYLMYIIVLEYIRPSM 204
Cdd:cd06173  251 AAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDEL 330
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 442619939 205 --RTLGLNMAV-GLFYCLGLVFTPWLAVLVGHWQIYLACTSLPILLVVLYYF 253
Cdd:cd06173  331 rgRVFSVYNALnSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLL 382
MFS_SV2 cd17363
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic ...
125-282 6.65e-04

Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. The SV2 family belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340921 [Multi-domain]  Cd Length: 474  Bit Score: 42.48  E-value: 6.65e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 125 SLFFIGSVVGTLFYGLLSDKIGRVPALI--LSNFCGFAgdFSTIFTKSVATFTLCRFISGLAADTNFYLMYIIVLEYIRP 202
Cdd:cd17363   41 LIVYLGMMVGAFVWGGLADKLGRKQCLLiaLSVNGVFA--FLSSFVQGYGFFLFCRLLSGIGIGGSIPIVFSYFAEFLAR 118
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 203 SMRTLGLNMaVGLFYCLGLVFTPWLA-VLVGH---------------WQIYLACTSLPILLVVLYYFVVQESAQWLVTRN 266
Cdd:cd17363  119 EKRGEHLSW-LCMFWMIGGLYASAMAwAIIPHygwgfsmgtayqfhsWRVFVIVCALPSVASVVALTFMPESPRFLLEVG 197
                        170
                 ....*....|....*.
gi 442619939 267 DIDGAIVRLKRVAKFN 282
Cdd:cd17363  198 KHDEAWMILKQVHDTN 213
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
379-506 6.80e-04

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 42.11  E-value: 6.80e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 379 DRIGRKGMASGSLLVGGLFTAAAGIAiayqqhnHNAILLacltIAARF--GVAISYESGSQYA--TELIPTCVRGQGVAA 454
Cdd:COG0477   74 DRYGRKRVLLIGLLLFGLASLLCGLA-------PSPELL----IAARAlqGIGAGGLMPGALAliAELFPARERGRALGL 142
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 442619939 455 VHVAGFAASFLAPYI-LWLGTFFK-AAPSIILGVLFFAGSFVCLLLPETLNRSL 506
Cdd:COG0477  143 WGAAIGLGLALGPLLgGLLVAALGwRWIFLINAPLGLLALVLRLRLPESRGLLL 196
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
379-502 8.01e-04

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 41.96  E-value: 8.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939  379 DRIGRKGMASGSLLVGGLFTAAAGIAIAYQQhnhnailLACLTIAARFGVAISYESGSQYATELIPTCVRGQGVAAVH-- 456
Cdd:TIGR00895  77 DRIGRRRVLLWSILLFSVFTLLCALATNVTQ-------LLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFcg 149
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 442619939  457 ------VAGFAASFLAPYILWLGTFF--KAAPSIILGVLFFAgsfvcllLPETL 502
Cdd:TIGR00895 150 ypigaaVGGFLAGWLIPVFGWRSLFYvgGIAPLLLLLLLMRF-------LPESI 196
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
379-502 1.29e-03

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 41.11  E-value: 1.29e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 379 DRIGRKGMASGSLLVGGLFTAAAGIAiayqqhnHNAILLACLTIAARFGVAISYESGSQYATELIPTCVRGQGVAAVHVA 458
Cdd:COG2814   70 DRFGRRRVLLLGLLLFALGSLLCALA-------PSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAG 142
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 442619939 459 GFAASFLAPYI-LWLGTFFKAAPSIILGVLFFAGSFVCLL--LPETL 502
Cdd:COG2814  143 LGLGPALGPLLgGLLADLFGWRWVFLVNAVLALLALLLLLrlLPESR 189
PRK11102 PRK11102
Bcr/CflA family multidrug efflux MFS transporter;
116-185 1.48e-03

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182964 [Multi-domain]  Cd Length: 377  Bit Score: 41.05  E-value: 1.48e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 116 SAYKARIGQSLFFIGSVVGTLFYGLLSDKIGRVPALILSNFCGFAGDFSTIFTKSVATFTLCRFISGLAA 185
Cdd:PRK11102  24 SAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGLAA 93
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
115-255 1.83e-03

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 40.64  E-value: 1.83e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 115 DSAYKARIGQSLFFIGSVVGTLFYGLLSDKIGRVPALILSNFCGFAGDFSTIFTKSVATFTLCRFISGLAADTN-FYLMY 193
Cdd:cd17330   31 ASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTGGNVsVAQAY 110
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 442619939 194 IIVLEYIRPSMRTLG-LNMAVGLFYCLGLVFTPWLAVLVGHWQIYLACTSLPILLVVLYYFVV 255
Cdd:cd17330  111 IADITDEEERAKAFGiISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALALLNLVLVLFFL 173
PRK15403 PRK15403
multidrug efflux MFS transporter MdtM;
125-182 2.13e-03

multidrug efflux MFS transporter MdtM;


Pssm-ID: 237958 [Multi-domain]  Cd Length: 413  Bit Score: 40.58  E-value: 2.13e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 442619939 125 SLFFIGSVVGTLFYGLLSDKIGRVPALILSNFCGFAGDFSTIFTKSVATFTLCRFISG 182
Cdd:PRK15403  58 SLYLAGGMALQWLLGPLSDRIGRRPVLITGALIFTLACAATLFTTSMTQFLIARFIQG 115
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
379-525 2.15e-03

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 40.62  E-value: 2.15e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 379 DRIGRKGMASGSLLVGGLFTAAAGIAIAYqqhnhnAILLACLTIAArFGVAISYESGSQYATELIPTcVRGQGVAAVHVA 458
Cdd:cd17478   56 DRKPRRYLLPLGPLLTGLGLSLLGFAPNY------WLLLLLVALAG-IGSAAFHPEGARLASQAAGG-RRGLAMSIFSVG 127
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 442619939 459 GFAASFLAP-YILWLGTFFKAAPSIILGVLffAGSFVCLLLPETLNRSLPTTIEEGEVFGKGERMFDF 525
Cdd:cd17478  128 GNLGFALGPlIAAALVALFGGLGLLILLII--PGLAVALLLLRLRPLKKPEAKKAAAKSSARSTLKGV 193
PRK11551 PRK11551
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
129-262 2.32e-03

putative 3-hydroxyphenylpropionic transporter MhpT; Provisional


Pssm-ID: 236927 [Multi-domain]  Cd Length: 406  Bit Score: 40.72  E-value: 2.32e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 129 IGSVVGTLFYGLLSDKIGRVPALILSnFCGFaGDFStIFTKSVATFT---LCRFISGL---AADTNfylMYIIVLEYIRP 202
Cdd:PRK11551  61 LGLLPGALLGGRLADRIGRKRILIVS-VALF-GLFS-LATAQAWDFPsllVARLLTGVglgGALPN---LIALTSEAVGP 134
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 442619939 203 SMRtlglNMAVGLFYClGLVFTPWLAVLVG-------HWQ-IYLACTSLPILLVVLYYFVVQESAQWL 262
Cdd:PRK11551 135 RLR----GTAVSLMYC-GVPFGGALASVIGvlaagdaAWRhIFYVGGVGPLLLVPLLMRWLPESRAFA 197
MFS_GLUT8_Class3 cd17433
Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of ...
125-506 2.88e-03

Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 8 (GLUT8) is also called Solute carrier family 2, facilitated glucose transporter member 8 (SLC2A8) or glucose transporter type X1 (GLUTX1). It is classified as a Class 3 GLUT protein and is an insulin-regulated facilitative glucose transporter predominantly expressed in testis and brain. It can also transport fructose and galactose. SLC2A8 knockout mice were viable, developed normally, and display only a very mild phenotype, including mild alterations in the brain (increased proliferation of hippocampal neurons), heart (impaired transmission of electrical wave through the atrium), and sperm cells (reduced number of motile sperm cells). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340991 [Multi-domain]  Cd Length: 416  Bit Score: 40.25  E-value: 2.88e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 125 SLFFIGSVVGTLFYGLLSDKIGRVPALILSNFCGFAGDFSTIFTKSVATFTLCRFISGLAADTNFYLMYIIVLEYIRPSM 204
Cdd:cd17433   48 SVVTLGAAAGGVLGGWIVDRAGRKLSLMLCSVPFIAGFTVITAAQNVWMLYVGRLLTGLASGVTSLVVPVYISEIAHPRV 127
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 205 R-TLG----LNMAVGLF--YCLGLVFT-PWLAVLvghwqiylacTSLPILLVVLYYFVVQESAQWLVTRNDIDGAIVRLK 276
Cdd:cd17433  128 RgTLGscvqLMVVIGIMgaYLAGLVLDwRWLAVL----------GSIPPTLMLLLMCFMPETPRFLLTQHRRQEAMAALR 197
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 277 RVakfngcRVSQADF-DEFRRHCQMTHEmlggddKKQATLLDMFRTPRMRKNTLI----LFFKSM--VITLCYDAVSRNV 349
Cdd:cd17433  198 FL------RGPDQGWeWECIGIEQSFHL------EEQSFSLALLKQPGIYKPLIIgvslMAFQQLtgINAVMFYAETIFE 265
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 350 EGMGISPFIMFSLSALAVLPSSVLLVLLQDRIGRKGMASGSLLVGGLFTAAAGIAiayqqhnhnAILLACLTIAarfGVA 429
Cdd:cd17433  266 EAKFKDSSVASVIVAAIQVLFTAVAALIMDRAGRKVLLVLSGVVMVFSTAAFGWL---------AVGSMGFFIA---GFA 333
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 430 ISYESGSQYA-TELIPTCVRGQGVAAVHVAGFAASF------------LAPYilwlGTFFKAAPSIILGVLffagsFVCL 496
Cdd:cd17433  334 VGWGPIPWLVmSEIFPLHVRGVASGICVLTNWLMAFlvtkefsslmevLSSY----GTFWLFSAFCAFSVL-----FTLF 404
                        410
                 ....*....|
gi 442619939 497 LLPETLNRSL 506
Cdd:cd17433  405 CVPETKGKTL 414
MFS_ShiA_like cd17369
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ...
379-498 4.67e-03

Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340927 [Multi-domain]  Cd Length: 408  Bit Score: 39.82  E-value: 4.67e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 379 DRIGRKGMasgsLLVGGLFTAAAGIAI--AYQQHNHNAILLACLTIAArFGVAISYESGSQYATELIPTCVRGQGVA-AV 455
Cdd:cd17369  289 DRVGRRPV----YLAGALLAALFAFPFfwLLDTGSTWLIVLAAVVVLG-VLHGMMYGPQAAFLAELFPTRVRYTGASlGY 363
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 442619939 456 HVAGFAASFLAPYI-LWLgtfFKAAPSIILGVLFFAG----SFVCLLL 498
Cdd:cd17369  364 QLGAILGGGFAPLIaTAL---VAATGSWWPVALYLAAlaviSLVAALF 408
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
379-513 5.14e-03

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 39.49  E-value: 5.14e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 379 DRIGRKGMASGSLLVGGLFTAAAGIAiayqqhnHNAILLACLTIAARFGVAISYESGSQYATELIPTCVRGQGV----AA 454
Cdd:cd17365   59 DRFGRKRVLLVSVALFGLFTLLTAFA-------QSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVtlmfCG 131
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 455 VHV----AGFAASFLAPYILWLGTFFKAA--PSIIL-----GVLFFAGSFVCLLLPETLNRSLPTTIEEG 513
Cdd:cd17365  132 YPLgaalGGFLAAALIPAFGWRSVFLLGGvpPLILLpllrgTLLLWVTFFMGLLLVYLLNSWLPKLMVEA 201
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
391-499 5.35e-03

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 39.48  E-value: 5.35e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 391 LLVGGLFTAAAGIAIAYQQHNHNAILLACLTIAARFGVAISYesGSQYATELIPTCVRGQGVAAVHVAGFAASFLAPYIL 470
Cdd:cd17473  265 LLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPT--LNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVL 342
                         90       100       110
                 ....*....|....*....|....*....|..
gi 442619939 471 -WLG--TFFKAAPSIILGVLFFAGSFVCLLLP 499
Cdd:cd17473  343 gPLVnlTGGLSGAFLILGVLALVLAIVLLLLR 374
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
379-501 6.04e-03

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 39.11  E-value: 6.04e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 379 DRIGRKGMASGSLLVGGLFTAAAGIAiayqqhnHNAILLACLTIAARFGVAISYESGSQYATELIPTCVRGQGVAAVHVA 458
Cdd:cd17489   56 DRFGRKRLLLIGLLIFALATLLYLLA-------TSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLA 128
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 442619939 459 GFAASFLAPYI-LWLGTFFKAAPSIILGVLF-FAGSFVCLLLPET 501
Cdd:cd17489  129 TTLAMALGPALgLFLYQHLGFAVLFIVAAVLaLLALLLVFLVKDP 173
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
125-498 6.16e-03

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 39.09  E-value: 6.16e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 125 SLFFIGSVVGTLFYGLLSDKIGR----VPALIL----SNFCGFAGDFstiftksvATFTLCRFISGLAADTNFYLMYIIV 196
Cdd:cd17474   41 TAFTLPAAVLMPVAGVLADRFGRkkvlLPGLLLfgigGLLCGLSDSF--------ALLLAGRALQGIGAAGLGPLALTLI 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 197 LEYIRPSMRT--LGLNMAVgLFycLGLVFTPWL-AVLVGHWQIY---LACTSLPILLVVLYYFVVQESAQWLVTRNDIDG 270
Cdd:cd17474  113 GDLFEGGERAkaMGLYEAA-LG--LGIAVGPLLgGLLAAISWRYpffLLAALIPVAFLAILFLLPEPKEKAKSSSATKLR 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 271 AIVRLKRVAKFNGCRVSQADFdefrrhcqmtheMLGgddkkqatlldmfrtprmrkNTLILFFKSMVITLCYDAvsrNVE 350
Cdd:cd17474  190 DLKKALRGRGLLTFLVSAFLY------------FFL--------------------YFAFLTYLPFLLELLYGI---SPI 234
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 351 GMGISPFIMFSLSALAVLPSSVllvllqdRIGRKGMASGSLLVGGLFTAAAGIAIAYQqhnHNAILLACLTIAARFGVAI 430
Cdd:cd17474  235 IIGLLFAGWSVLLALGSLFVGR-------LLKKRFGARRILVIGLLLYALSLLLLGFV---PSLALLLIAIVLFGLGLGL 304
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 431 SYESGSQYATELIPTCVRGQGVAAVHVAGFAASFLAPYI--LWLGTFFKAAPSIILGVLFFAGSFVCLLL 498
Cdd:cd17474  305 NLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLfgLLLEIFGLSAPFLVGAAIALAAAVLLALL 374
MFS_GLUT10_12_Class3_like cd17362
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ...
129-261 7.62e-03

Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340920 [Multi-domain]  Cd Length: 389  Bit Score: 38.87  E-value: 7.62e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 129 IGSVVGTLFYGLLSDKIGRVPALILSNFCGFAGDFSTIFTKSVATFTLCRFISGLAADTNFYL--MYI--IVLEYIRPSM 204
Cdd:cd17362   50 LGALLGSLVAGALIDRLGRRKELILAALLYLVGSLVTGLAPSYPVLLVGRLIYGVGIGLAMHAapVYIaeTSPSHIRGLL 129
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 205 RTLGLNMAVG---LFYCLGLVFtpwlAVLVGHWQIYLACTSLPILLVVLYYFVVQESAQW 261
Cdd:cd17362  130 VSLKELFIVLgilLGYVSGYAF----ADVVGGWRYMYGLAAPPALLLGIGMWFLPPSPRW 185
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
116-261 8.13e-03

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 38.68  E-value: 8.13e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619939 116 SAYKARIGQSLFFIGSVVGTLFYGLLSDKIGRVPALILSNFCGFAGDFSTIFTKSVATFTLCRFISGLAADTNFYLMYII 195
Cdd:COG0738  244 SEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIFSL 323
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 442619939 196 VLEyiRPSMRTLGLNMAVGLFYCLGLVFTPWLAVLVGH---WQIYLACTSLPILLVVLYYFVVQESAQW 261
Cdd:COG0738  324 ALD--GLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADafgLRAAFLVPLVCYLLILLLALALKRKRRK 390
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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