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    Fbxl15 F-box and leucine-rich repeat protein 15 [ Mus musculus (house mouse) ]

    Gene ID: 68431, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fbxl15provided by MGI
    Official Full Name
    F-box and leucine-rich repeat protein 15provided by MGI
    Primary source
    MGI:MGI:1915681
    See related
    Ensembl:ENSMUSG00000025226 AllianceGenome:MGI:1915681
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fbxo37; 0710008C12Rik
    Summary
    Predicted to be involved in several processes, including G2/M transition of mitotic cell cycle; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; and positive regulation of BMP signaling pathway. Predicted to be located in cytoplasm. Predicted to be part of SCF ubiquitin ligase complex. Is expressed in several structures, including craniocervical region bone; dorsal root ganglion; submandibular gland primordium; ventral grey horn; and vibrissa. Orthologous to human FBXL15 (F-box and leucine rich repeat protein 15). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in duodenum adult (RPKM 21.3), adrenal adult (RPKM 18.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Fbxl15 in Genome Data Viewer
    Location:
    19 C3; 19 38.81 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (46316623..46318885)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (46328184..46330446)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100 Neighboring gene RIKEN cDNA 4833438C02 gene Neighboring gene STARR-positive B cell enhancer ABC_E9457 Neighboring gene pleckstrin and Sec7 domain containing Neighboring gene CUE domain containing 2 Neighboring gene STARR-positive B cell enhancer ABC_E973 Neighboring gene predicted gene, 36493 Neighboring gene microRNA 146b Neighboring gene RIKEN cDNA 2310034G01 gene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Systematic analysis and nomenclature of mammalian F-box proteins. Jin J, et al. Genes Dev, 2004 Nov 1. PMID 15520277, Free PMC Article
    2. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    3. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
    4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in G2/M transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in G2/M transition of mitotic cell cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in bone mineralization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in bone mineralization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in dorsal/ventral pattern formation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of BMP signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of BMP signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SCF ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of SCF ubiquitin ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    F-box/LRR-repeat protein 15
    Names
    F-box only protein 37

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001378773.1 → NP_001365702.1  F-box/LRR-repeat protein 15 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC114539
      Conserved Domains (3) summary
      cd09293
      Location:175 → 304
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:125 → 151
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam00646
      Location:18 → 55
      F-box; F-box domain

    2. NM_133694.2 → NP_598455.2  F-box/LRR-repeat protein 15 isoform 1

      See identical proteins and their annotated locations for NP_598455.2

      Status: VALIDATED

      Source sequence(s)
      AI594908, AW124512, AW825726, CK791452
      Consensus CDS
      CCDS38007.1
      UniProtKB/Swiss-Prot
      Q3T9R4, Q91W61
      Related
      ENSMUSP00000026256.3, ENSMUST00000026256.9
      Conserved Domains (3) summary
      cd09293
      Location:139 → 268
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:62 → 88
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam00646
      Location:18 → 55
      F-box; F-box domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      46316623..46318885
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036161678.1 → XP_036017571.1  F-box/LRR-repeat protein 15 isoform X1

      UniProtKB/Swiss-Prot
      Q3T9R4, Q91W61
      Related
      ENSMUSP00000137489.2, ENSMUST00000177667.2
      Conserved Domains (3) summary
      cd09293
      Location:139 → 268
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:62 → 88
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam00646
      Location:18 → 55
      F-box; F-box domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91W61.2 GenPept UniProtKB/Swiss-Prot:Q91W61

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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