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    CrzR Corazonin receptor [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39409, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CrzRprovided by FlyBase
    Official Full Name
    Corazonin receptorprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036278
    Locus tag
    Dmel_CG10698
    See related
    AllianceGenome:FB:FBgn0036278
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0170980.196; anon-WO0170980.197; CG10698; Crz-R; crzR; CRZR; DCR; DGRHRII; Dmel\CG10698; GRH R2; GRH-RII; GRHRII; GRHRII_Dro
    Summary
    Enables corazonin receptor activity. Involved in acetaldehyde metabolic process; neuropeptide signaling pathway; and response to ethanol. Located in plasma membrane. Is expressed in several structures, including adult abdominal neuromere; ejaculatory duct; gland; and seminal vesicle. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CrzR in Genome Data Viewer
    Location:
    69B2-69B2; 3-38 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (12339116..12351544, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (12332216..12344644, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45444 Neighboring gene uncharacterized protein Neighboring gene sodium chloride cotransporter 69 Neighboring gene long non-coding RNA:CR45824 Neighboring gene uncharacterized protein Neighboring gene Odorant-binding protein 69a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of a G protein-coupled receptor for the neuropeptide proctolin in Drosophilamelanogaster. Johnson EC, et al. Proc Natl Acad Sci U S A, 2003 May 13. PMID 12730362, Free PMC Article
    2. Unexpected role of a conserved domain in the first extracellular loop in G protein-coupled receptor trafficking. Rizzo MJ, et al. Biochem Biophys Res Commun, 2018 Sep 10. PMID 30064912
    3. Ejaculation Induced by the Activation of Crz Neurons Is Rewarding to Drosophila Males. Zer-Krispil S, et al. Curr Biol, 2018 May 7. PMID 29681474
    4. Analysis of Peptide Ligand Specificity of Different Insect Adipokinetic Hormone Receptors. Marchal E, et al. Int J Mol Sci, 2018 Feb 11. PMID 29439466, Free PMC Article
    5. Molecular identification of the insect adipokinetic hormone receptors. Staubli F, et al. Proc Natl Acad Sci U S A, 2002 Mar 19. PMID 11904407, Free PMC Article

    See all (80) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Study shows that the CrzR is expressed in the fat body and salivary glands of adult flies, and signalling through the CrzR in the periphery during metabolic stress results in increased nutrient intake and reallocated energy stores enabling the fly to reestablish homeostasis.
      Title: Systemic corazonin signalling modulates stress responses and metabolism in Drosophila.
    2. CrzR-associated signaling pathway is critical for ethanol detoxification via Crz-dependent regulation of ALDH activity and Crz-independent transcriptional regulation of ADH.
      Title: Regulation of ethanol-related behavior and ethanol metabolism by the Corazonin neurons and Corazonin receptor in Drosophila melanogaster.
    3. characterization of corazonin receptor in insects
      Title: Discovery of a novel insect neuropeptide signaling system closely related to the insect adipokinetic hormone and corazonin hormonal systems.
    4. Molecular cloning and identification of CG10698 as a corazonin receptor.
      Title: Molecular cloning and functional expression of a Drosophila corazonin receptor.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables G protein-coupled receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables corazonin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables corazonin receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables corazonin receptor activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables neuropeptide receptor activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    involved_in G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in acetaldehyde metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in behavioral response to ethanol IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to ethanol IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuropeptide signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neuropeptide signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IC
    Inferred by Curator
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    corazonin receptor
    Names
    CG10698-PA
    CG10698-PB
    Crz receptor
    CrzR-PA
    CrzR-PB
    Drm-AKH receptor-2
    GRHRII
    drosophila corazonin receptor

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      12339116..12351544 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140314.4 → NP_648571.1  corazonin receptor, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648571.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8ITC8, Q8MX81, Q8SYP3, Q9VTW7
      Related
      FBpp0075721
      Conserved Domains (2) summary
      pfam00001
      Location:135 → 412
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:127 → 260
      7tm_4; Olfactory receptor

    2. NM_001274826.1 → NP_001261755.1  corazonin receptor, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261755.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PF00, Q8ITC8, Q8MX81
      Conserved Domains (2) summary
      pfam00001
      Location:135 → 412
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:127 → 260
      7tm_4; Olfactory receptor
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PF00 M9PF00
    Q8ITC8 Q8ITC8
    Q8MX81 Q8MX81
    Q9VTW7 Q9VTW7

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