NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|442631927|ref|NP_001261755|]
View 

corazonin receptor, isoform B [Drosophila melanogaster]

Protein Classification

G protein-coupled receptor family protein; olfactory receptor subfamily 2A protein( domain architecture ID 11607494)

G protein-coupled receptor family protein is a seven-transmembrane G protein-coupled receptor (7TM-GPCR) family protein which typically transmits an extracellular signal into the cell by the conformational rearrangement of the 7TM helices and by the subsequent binding and activation of an intracellular heterotrimeric G protein; GPCR ligands include light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters| olfactory receptor (OR) subfamily 2A protein, such as human olfactory receptor 2A2 and related proteins in other mammals and sauropsids; ORs play a central role in olfaction, the sense of smell, and belong to the class A rhodopsin-like family of seven-transmembrane G protein-coupled receptors (7TM GPCRs)

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
7tmA_GnRHR_invertebrate cd15384
invertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
119-419 1.53e-168

invertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


:

Pssm-ID: 320506 [Multi-domain]  Cd Length: 293  Bit Score: 482.71  E-value: 1.53e-168
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 119 LLKVYVLAVMALFSLLGNLLTIWNIYKTRISRRnsrhtwsAIYSLMFHLSIADVLVTWFCIIGEAAWCYTVQWLANELTC 198
Cdd:cd15384    1 LLKIVVLAVMFVISFIGNLLTIIQIYRLRRSRR-------TIYSLLLHLAIADLLVTFFCIPSEAIWAYTVAWLAGNTMC 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 199 KLVKLFQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLNMAKRCHRLLGGTYILSLVLSLPQFFIFHVARGPFVEEFYQCVT 278
Cdd:cd15384   74 KLVKYLQVFGLYLSTYITVLISLDRCVAILYPMKRNQAPERVRRMVTVAWILSPIFSIPQAVIFHVERGPFVEDFHQCVT 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 279 HGFYTADWQEQMYATFTLVFTFLLPLCILFGTYMSTFRTISSSEKMFQGSKlanysTAKLPTQTNRQRLIHKAKMKSLRI 358
Cdd:cd15384  154 YGFYTAEWQEQLYNMLSLVFMFPIPLVIMVTCYVLIFITLSKSSRDFQGLE-----IYTRNRGPNRQRLFHKAKVKSLRM 228
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 442631927 359 SVVIIIAFLICWTPYYVMMIMFMFLNPdKRLGDDLQDAIFFFGMSNSLVNPLIYGAFHLCP 419
Cdd:cd15384  229 SAVIVTAFILCWTPYYVIMIWFLFFNP-YPLNDILFDVIFFFGMSNSCVNPLIYGAFHITK 288
 
Name Accession Description Interval E-value
7tmA_GnRHR_invertebrate cd15384
invertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
119-419 1.53e-168

invertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320506 [Multi-domain]  Cd Length: 293  Bit Score: 482.71  E-value: 1.53e-168
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 119 LLKVYVLAVMALFSLLGNLLTIWNIYKTRISRRnsrhtwsAIYSLMFHLSIADVLVTWFCIIGEAAWCYTVQWLANELTC 198
Cdd:cd15384    1 LLKIVVLAVMFVISFIGNLLTIIQIYRLRRSRR-------TIYSLLLHLAIADLLVTFFCIPSEAIWAYTVAWLAGNTMC 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 199 KLVKLFQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLNMAKRCHRLLGGTYILSLVLSLPQFFIFHVARGPFVEEFYQCVT 278
Cdd:cd15384   74 KLVKYLQVFGLYLSTYITVLISLDRCVAILYPMKRNQAPERVRRMVTVAWILSPIFSIPQAVIFHVERGPFVEDFHQCVT 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 279 HGFYTADWQEQMYATFTLVFTFLLPLCILFGTYMSTFRTISSSEKMFQGSKlanysTAKLPTQTNRQRLIHKAKMKSLRI 358
Cdd:cd15384  154 YGFYTAEWQEQLYNMLSLVFMFPIPLVIMVTCYVLIFITLSKSSRDFQGLE-----IYTRNRGPNRQRLFHKAKVKSLRM 228
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 442631927 359 SVVIIIAFLICWTPYYVMMIMFMFLNPdKRLGDDLQDAIFFFGMSNSLVNPLIYGAFHLCP 419
Cdd:cd15384  229 SAVIVTAFILCWTPYYVIMIWFLFFNP-YPLNDILFDVIFFFGMSNSCVNPLIYGAFHITK 288
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
135-412 6.42e-38

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 141.28  E-value: 6.42e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927  135 GNLLTIWNIYKTRisrrnSRHTWSAIYslMFHLSIADVLVTWFCIIGEAAW-CYTVQWLANELTCKLVKLFQMFSLYLST 213
Cdd:pfam00001   1 GNLLVILVILRNK-----KLRTPTNIF--LLNLAVADLLFSLLTLPFWLVYyLNHGDWPFGSALCKIVGALFVVNGYASI 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927  214 YVLVLIGVDRWIAVKYPMKSLNMA--KRCHRLLGGTYILSLVLSLPQFFIFHVARGPFVEEFyQCVTHgFYTADWQEQMY 291
Cdd:pfam00001  74 LLLTAISIDRYLAIVHPLRYKRRRtpRRAKVLILVIWVLALLLSLPPLLFGWTLTVPEGNVT-VCFID-FPEDLSKPVSY 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927  292 ATFTLVFTFLLPLCILFGTYMSTFRTISSSEKmfqgsklanystaKLPTQTNRQRlihkaKMKSLRISVVIIIAFLICWT 371
Cdd:pfam00001 152 TLLISVLGFLLPLLVILVCYTLIIRTLRKSAS-------------KQKSSERTQR-----RRKALKTLAVVVVVFILCWL 213
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 442631927  372 PYYVMMIMFMFLNPDKRLgDDLQDAIF---FFGMSNSLVNPLIY 412
Cdd:pfam00001 214 PYHIVNLLDSLALDCELS-RLLDKALSvtlWLAYVNSCLNPIIY 256
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
79-381 6.32e-13

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 70.19  E-value: 6.32e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927  79 YAISNSSSLAHTNSRHEAPPMAEQVPEHVMDHAPQLSRSGLLKVYVLavMALFSLLGNLLTIWNIYKTRISrrnsrhTWS 158
Cdd:PHA03087   3 YTLTINTTIENTTDYYYDTYYDEDYADCDLNIGYDTNSTILIVVYST--IFFFGLVGNIIVIYVLTKTKIK------TPM 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 159 AIYSLmfHLSIADVLVTW---FCIIgeaaWCYTVQWLANELTCKLVKLFQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLN 235
Cdd:PHA03087  75 DIYLL--NLAVSDLLFVMtlpFQIY----YYILFQWSFGEFACKIVSGLYYIGFYNSMNFITVMSVDRYIAIVHPVKSNK 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 236 M--AKRCHRLLGGTYILSLVLSLPQFFIFHVARgpfVEEFYQCvtHGFYTAD---WqeQMYATFTL-VFTFLLPLCILFG 309
Cdd:PHA03087 149 IntVKYGYIVSLVIWIISIIETTPILFVYTTKK---DHETLIC--CMFYNNKtmnW--KLFINFEInIIGMLIPLTILLY 221
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 442631927 310 TYMSTFRTISSSEKmfqgsklanystaklptqtnrqrliHKAKMKSLRISVVIIIAFLICWTPYYVMMIMFM 381
Cdd:PHA03087 222 CYSKILITLKGINK-------------------------SKKNKKAIKLVLIIVILFVIFWLPFNVSVFVYS 268
 
Name Accession Description Interval E-value
7tmA_GnRHR_invertebrate cd15384
invertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
119-419 1.53e-168

invertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320506 [Multi-domain]  Cd Length: 293  Bit Score: 482.71  E-value: 1.53e-168
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 119 LLKVYVLAVMALFSLLGNLLTIWNIYKTRISRRnsrhtwsAIYSLMFHLSIADVLVTWFCIIGEAAWCYTVQWLANELTC 198
Cdd:cd15384    1 LLKIVVLAVMFVISFIGNLLTIIQIYRLRRSRR-------TIYSLLLHLAIADLLVTFFCIPSEAIWAYTVAWLAGNTMC 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 199 KLVKLFQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLNMAKRCHRLLGGTYILSLVLSLPQFFIFHVARGPFVEEFYQCVT 278
Cdd:cd15384   74 KLVKYLQVFGLYLSTYITVLISLDRCVAILYPMKRNQAPERVRRMVTVAWILSPIFSIPQAVIFHVERGPFVEDFHQCVT 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 279 HGFYTADWQEQMYATFTLVFTFLLPLCILFGTYMSTFRTISSSEKMFQGSKlanysTAKLPTQTNRQRLIHKAKMKSLRI 358
Cdd:cd15384  154 YGFYTAEWQEQLYNMLSLVFMFPIPLVIMVTCYVLIFITLSKSSRDFQGLE-----IYTRNRGPNRQRLFHKAKVKSLRM 228
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 442631927 359 SVVIIIAFLICWTPYYVMMIMFMFLNPdKRLGDDLQDAIFFFGMSNSLVNPLIYGAFHLCP 419
Cdd:cd15384  229 SAVIVTAFILCWTPYYVIMIWFLFFNP-YPLNDILFDVIFFFGMSNSCVNPLIYGAFHITK 288
7tmA_AKHR cd15382
adipokinetic hormone receptor, member of the class A family of seven-transmembrane G ...
119-415 1.76e-71

adipokinetic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flight, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. AKH is structurally related to the mammalian gonadotropin-releasing hormone (GnRH) and they share a common ancestor. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320504 [Multi-domain]  Cd Length: 298  Bit Score: 232.97  E-value: 1.76e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 119 LLKVYVLAVMALFSLLGNLLTIWNIYKTRiSRRNSRhtwsaIYSLMFHLSIADVLVTWFCIIGEAAWCYTVQWLANELTC 198
Cdd:cd15382    1 LVSIIVYSVLFLIAAVGNLTVLLILLRNR-RRKRSR-----VNILLMHLAIADLLVTFIMMPLEIGWAATVAWLAGDFLC 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 199 KLVKLFQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLNMAKRCHRLLGGTYILSLVLSLPQFFIFHVARGPFVEEFYQCVT 278
Cdd:cd15382   75 RLMLFFRAFGLYLSSFVLVCISLDRYFAILKPLRLSDARRRGRIMLAVAWVISFLCSIPQSFIFHVESHPCVTWFSQCVT 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 279 HGFYTADWQEQMYATFTLVFTFLLPLCILFGTYMSTFRTISSSEKMFQGSKLANYSTAKLptQTNRQRLIHKAKMKSLRI 358
Cdd:cd15382  155 FNFFPSHDHELAYNIFNMITMYALPLIIIVFCYSLILCEISRKSKEKKEDVSEKSSSVRL--RRSSVGLLERARSRTLKM 232
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 442631927 359 SVVIIIAFLICWTPYYVMMIMFMFLNPD-KRLGDDLQDAIFFFGMSNSLVNPLIYGAF 415
Cdd:cd15382  233 TIVIVLVFIICWTPYFIMSLWYWFDRESaSKVDPRIQKGLFLFAVSNSCMNPIVYGYF 290
7tmA_GnRHR-like cd15195
gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A ...
119-415 1.55e-67

gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Gonadotropin-releasing hormone (GnRH) and adipokinetic hormone (AKH) receptors share strong sequence homology to each other, suggesting that they have a common evolutionary origin. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flying, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320323 [Multi-domain]  Cd Length: 293  Bit Score: 222.66  E-value: 1.55e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 119 LLKVYVLAVMALFSLLGNLLTIWNIykTRISRRNSRhtwsaIYSLMFHLSIADVLVTWFCIIGEAAWCYTVQWLANELTC 198
Cdd:cd15195    1 LVRVLVTWVLFVISAAGNLTVLIQL--FRRRRAKSH-----IQILIMHLALADLMVTFFNMPMDAVWNYTVEWLAGDLMC 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 199 KLVKLFQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLNMAKRCHRLLGGTYILSLVLSLPQFFIFHVAR-GPFVEEFYQCV 277
Cdd:cd15195   74 RVMMFLKQFGMYLSSFMLVVIALDRVFAILSPLSANQARKRVKIMLTVAWVLSALCSIPQSFIFSVLRkMPEQPGFHQCV 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 278 THGFYTADWQEQMYATFTLVFTFLLPLCILFGTYMSTFRTISSSEKMFQGSKLANYstaklptQTNRQRLIHKAKMKSLR 357
Cdd:cd15195  154 DFGSAPTKKQERLYYFFTMILSFVIPLIITVTCYLLILFEISKMAKRARDTPISNR-------RRSRTNSLERARMRTLR 226
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 358 ISVVIIIAFLICWTPYYVMMIMFMFlNPDKRLGDD--LQDAIFFFGMSNSLVNPLIYGAF 415
Cdd:cd15195  227 MTALIVLTFIVCWGPYYVLGLWYWF-DKESIKNLPpaLSHIMFLLGYLNPCLHPIIYGVF 285
7tmA_GnRHR_vertebrate cd15383
vertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
121-415 1.89e-65

vertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320505 [Multi-domain]  Cd Length: 295  Bit Score: 217.24  E-value: 1.89e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 121 KVYVLAVMALFSLLGNLLTIWNIYKTRISRRnsrhtwSAIYSLMFHLSIADVLVTWFCIIGEAAWCYTVQWLANELTCKL 200
Cdd:cd15383    3 RVAVTFVLFVLSACSNLAVLWSATRNRRRKL------SHVRILILHLAAADLLVTFVVMPLDAAWNVTVQWYAGDLACRL 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 201 VKLFQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLNMAKRCHRLLGGTYILSLVLSLPQFFIFHVARGPFVEEFYQCVTHG 280
Cdd:cd15383   77 LMFLKLFAMYSSAFVTVVISLDRHAAILNPLAIGSARRRNRIMLCAAWGLSALLALPQLFLFHTVTATPPVNFTQCATHG 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 281 FYTADWQEQMYATFTLVFTFLLPLCILFGTYMSTFRTISSSEKMfqgSKLANYSTAKLPTQTNRqrlIHKAKMKSLRISV 360
Cdd:cd15383  157 SFPAHWQETLYNMFTFFCLFLLPLLIMIFCYTRILLEISRRMKE---KKDSAKNEVALRSSSDN---IPKARMRTLKMTI 230
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 442631927 361 VIIIAFLICWTPYYVMMIMFMFLNPD--KRLGDDLQDAIFFFGMSNSLVNPLIYGAF 415
Cdd:cd15383  231 VIVSSFIVCWTPYYLLGLWYWFSPEMleQTVPESLSHILFLFGLLNACLDPLIYGLF 287
7tmA_Vasopressin-like cd14986
vasopressin receptors and its related G protein-coupled receptors, member of the class A ...
121-415 9.17e-63

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.


Pssm-ID: 320117 [Multi-domain]  Cd Length: 295  Bit Score: 209.92  E-value: 9.17e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 121 KVYVLAVMALFSLLGNLLTIWNIYKTRisRRNSRHTwsaiySLMFHLSIADVLVTWFCIIGEAAWCYTVQWLANELTCKL 200
Cdd:cd14986    3 RVAVLGVLFVFTLVGNGLVILVLRRKR--KKRSRVN-----IFILNLAIADLVVAFFTVLTQIIWEATGEWVAGDVLCRI 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 201 VKLFQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLNMAKRCHRLLGGTYILSLVLSLPQFFIfhvargpFVEE-----FYQ 275
Cdd:cd14986   76 VKYLQVVGLFASTYILVSMSLDRYQAIVKPMSSLKPRKRARLMIVVAWVLSFLFSIPQLVI-------FVERelgdgVHQ 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 276 CVTHGFytADWQEQMYATFTLVFTFLLPLCILFGTYMSTFRTISSSEKMFQGSKLANYSTAK--LPTQTNRQRLIHKAKM 353
Cdd:cd14986  149 CWSSFY--TPWQRKVYITWLATYVFVIPLIILSYCYGRILRTIWIRSRQKTDRPIAPTAMSCrsVSCVSSRVSLISRAKI 226
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 442631927 354 KSLRISVVIIIAFLICWTPYYVMMIMFMFlNPDKRLGDDLQDAIFFFGMSNSLVNPLIYGAF 415
Cdd:cd14986  227 KTIKMTLVIILAFILCWTPYFIVQLLDVY-AGMQQLENDAYVVSETLASLNSALNPLIYGFF 287
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
124-416 2.04e-54

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 187.11  E-value: 2.04e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 124 VLAVMALFSLLGNLLTIWNIYKTRisrrnsrHTWSAIYSLMFHLSIADVLVTWFCIIGEAAWCYTVQWLANELTCKLVKL 203
Cdd:cd00637    4 LYILIFVVGLVGNLLVILVILRNR-------RLRTVTNYFILNLAVADLLVGLLVIPFSLVSLLLGRWWFGDALCKLLGF 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 204 FQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLNM--AKRCHRLLGGTYILSLVLSLPQFFIFHVargpfVEEFYQCVTHGF 281
Cdd:cd00637   77 LQSVSLLASILTLTAISVDRYLAIVHPLRYRRRftRRRAKLLIALIWLLSLLLALPPLLGWGV-----YDYGGYCCCCLC 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 282 YTADWQEQMYATFTLVFTFLLPLCILFGTYMSTFRTISSSEKMFQGSklanystaklpTQTNRQRLIHKAKMKSLRISVV 361
Cdd:cd00637  152 WPDLTLSKAYTIFLFVLLFLLPLLVIIVCYVRIFRKLRRHRRRIRSS-----------SSNSSRRRRRRRERKVTKTLLI 220
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 442631927 362 IIIAFLICWTPYYVMMIMFMFLNPDKRLGDDLQDAIFFFGMSNSLVNPLIYGAFH 416
Cdd:cd00637  221 VVVVFLLCWLPYFILLLLDVFGPDPSPLPRILYFLALLLAYLNSAINPIIYAFFN 275
7tmA_Vasopressin_Oxytocin cd15196
vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...
122-415 9.64e-54

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320324 [Multi-domain]  Cd Length: 264  Bit Score: 184.75  E-value: 9.64e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 122 VYVLAVMALFSLLGNLLTIWNIYktrisRRNSRHtwSAIYSLMFHLSIADVLVTWFCIIGEAAWCYTVQWLANELTCKLV 201
Cdd:cd15196    4 IAVLATILVLALFGNSCVLLVLY-----RRRRKL--SRMHLFILHLSVADLLVALFNVLPQLIWDITYRFYGGDLLCRLV 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 202 KLFQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLNM-AKRCHRLLGGTYILSLVLSLPQFFIFH-VARGPFVeefYQCVTH 279
Cdd:cd15196   77 KYLQVVGMYASSYVLVATAIDRYIAICHPLSSHRWtSRRVHLMVAIAWVLSLLLSIPQLFIFSyQEVGSGV---YDCWAT 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 280 gfYTADWQEQMYATFTLVFTFLLPLCILFGTYMSTFRTisssekmfqgsklanystaklptqtnrqrlIHKAKMKSLRIS 359
Cdd:cd15196  154 --FEPPWGLRAYITWFTVAVFVVPLIILAFCYGRICYV------------------------------VWRAKIKTVKLT 201
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 442631927 360 VVIIIAFLICWTPYYVMMiMFMFLNPDKRLGDDLQDAIFFFGMSNSLVNPLIYGAF 415
Cdd:cd15196  202 LVVVACYIVCWTPFFVVQ-MWAAWDPTAPIEGPAFVIIMLLASLNSCTNPWIYLAF 256
7tmA_NPSR cd15197
neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled ...
124-418 1.23e-41

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR is widely expressed in the brain, and its activation induces an elevation of intracellular calcium and cAMP concentrations, presumably by coupling to G(s) and G(q) proteins. Mutations in NPSR have been associated with an increased susceptibility to asthma. NPSR was originally identified as an orphan receptor GPR154 and is also known as G protein receptor for asthma susceptibility (GPRA) or vasopressin receptor-related receptor 1 (VRR1).


Pssm-ID: 320325 [Multi-domain]  Cd Length: 294  Bit Score: 152.96  E-value: 1.23e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 124 VLAVMALFSLLGNLLTIWNIYKTRisRRNSRHTWsaiysLMFHLSIADVLVTWFCIIGEAAWCYTVQWLANELTCKLVKL 203
Cdd:cd15197    6 TLWVLFVFIVVGNSSVLFALWMRK--AKKSRMNF-----FITQLAIADLCVGLINVLTDIIWRITVEWRAGDFACKVIRY 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 204 FQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLNMAKRCHRLLGGTYILSLVLSLPQFFIFhvARGPFVEEFYQCVTHgfYT 283
Cdd:cd15197   79 LQVVVTYASTYVLVALSIDRYDAICHPMNFSQSGRQARVLICVAWILSALFSIPMLIIF--EKTGLSNGEVQCWIL--WP 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 284 ADWQEQMYATFTLVFTFLLPLCILFGTYMSTFRTISSSEKMFQGSKLANYSTAKLPTQTNRQrLIHKAKMKSLRISVVII 363
Cdd:cd15197  155 EPWYWKVYMTIVAFLVFFIPATIISICYIIIVRTIWKKSKIQVTINKAGLHDGSSRRSSSRG-IIPRAKIKTIKMTFVIV 233
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 364 IAFLICWTPYYVMMIMFMF-LNPDKRlgDDLQDAIFFFGMS--NSLVNPLIYGAF--HLC 418
Cdd:cd15197  234 TVFIICWSPYFVFDLLDVFgLLPRSK--TKIAAATFIQSLAplNSAINPLIYCLFstHLC 291
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
122-416 5.72e-41

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 150.83  E-value: 5.72e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 122 VYVLAVMALFSLLGNLLTIWNIYKtrisrrnSRHTWSAIYSLMFHLSIADVLVTWFCI---IGEAAwcyTVQWLANELTC 198
Cdd:cd14993    4 IVLYVVVFLLALVGNSLVIAVVLR-------NKHMRTVTNYFLVNLAVADLLVSLFCMpltLLENV---YRPWVFGEVLC 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 199 KLVKLFQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLNM--AKRCHRLLGGTYILSLVLSLPQFFIFHVARGPFVE----E 272
Cdd:cd14993   74 KAVPYLQGVSVSASVLTLVAISIDRYLAICYPLKARRVstKRRARIIIVAIWVIAIIIMLPLLVVYELEEIISSEpgtiT 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 273 FYQCVTHgFYTADWQeQMYATFTLVFTFLLPLCILFGTYMSTFRTISSSEKMFQGSKLANYSTAKlptqtnrqrlIHKAK 352
Cdd:cd14993  154 IYICTED-WPSPELR-KAYNVALFVVLYVLPLLIISVAYSLIGRRLWRRKPPGDRGSANSTSSRR----------ILRSK 221
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 442631927 353 MKSLRISVVIIIAFLICWTPYYVMMIMFMFLNPDKRLGDDLQDAIFFF----GMSNSLVNPLIYGAFH 416
Cdd:cd14993  222 KKVARMLIVVVVLFALSWLPYYVLSILLDFGPLSSEESDENFLLILPFaqllGYSNSAINPIIYCFMS 289
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
135-412 6.42e-38

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 141.28  E-value: 6.42e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927  135 GNLLTIWNIYKTRisrrnSRHTWSAIYslMFHLSIADVLVTWFCIIGEAAW-CYTVQWLANELTCKLVKLFQMFSLYLST 213
Cdd:pfam00001   1 GNLLVILVILRNK-----KLRTPTNIF--LLNLAVADLLFSLLTLPFWLVYyLNHGDWPFGSALCKIVGALFVVNGYASI 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927  214 YVLVLIGVDRWIAVKYPMKSLNMA--KRCHRLLGGTYILSLVLSLPQFFIFHVARGPFVEEFyQCVTHgFYTADWQEQMY 291
Cdd:pfam00001  74 LLLTAISIDRYLAIVHPLRYKRRRtpRRAKVLILVIWVLALLLSLPPLLFGWTLTVPEGNVT-VCFID-FPEDLSKPVSY 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927  292 ATFTLVFTFLLPLCILFGTYMSTFRTISSSEKmfqgsklanystaKLPTQTNRQRlihkaKMKSLRISVVIIIAFLICWT 371
Cdd:pfam00001 152 TLLISVLGFLLPLLVILVCYTLIIRTLRKSAS-------------KQKSSERTQR-----RRKALKTLAVVVVVFILCWL 213
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 442631927  372 PYYVMMIMFMFLNPDKRLgDDLQDAIF---FFGMSNSLVNPLIY 412
Cdd:pfam00001 214 PYHIVNLLDSLALDCELS-RLLDKALSvtlWLAYVNSCLNPIIY 256
7tmA_V1aR cd15385
vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
120-417 3.14e-36

vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; V1a-type receptor is a G(q/11)-coupled receptor that mediates blood vessel constriction. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320507 [Multi-domain]  Cd Length: 301  Bit Score: 138.03  E-value: 3.14e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 120 LKVYVLAVMALFSLLGNLLTIWNIYKTRisRRNSRhtwsaIYSLMFHLSIADVLVTWFCIIGEAAWCYTVQWLANELTCK 199
Cdd:cd15385    2 LEIAVLAVIFAVAVIGNSSVLLALYKTK--KKASR-----MHLFIKHLSLADLVVAFFQVLPQLCWDITYRFYGPDFLCR 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 200 LVKLFQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLNMA-KRCHRLLGGTYILSLVLSLPQFFIFHVARGPFVEEFYQCVT 278
Cdd:cd15385   75 IVKHLQVLGMFASTYMLVMMTADRYIAICHPLKTLQQPtKRSYLMIGSAWALSFILSTPQYFIFSLSEIENGSGVYDCWA 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 279 HgfYTADWQEQMYATFTLVFTFLLPLCILFGTYMSTFRTISSSEKMFQGSKLANYSTAK--LPTQTNRQRLIHKAKMKSL 356
Cdd:cd15385  155 N--FIVPWGIKAYITWITISIFVVPVIILLTCYGFICYNIWRNIKCKTRRGLSDNALKNilLAVCVSSVKTISRAKIRTV 232
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 442631927 357 RISVVIIIAFLICWTPYYVMMIMFMFlnPDKRLGDDLQDAIF----FFGMSNSLVNPLIYGAF--HL 417
Cdd:cd15385  233 KMTFVIVLAYIVCWAPFFTIQMWSVW--DQNFPWDESENTAVtitaLLASLNSCCNPWIYMFFsgHL 297
7tmA_OT_R cd15387
oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
120-415 2.54e-34

oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Oxytocin is a peptide of nine amino acids synthesized in the hypothalamus and is released from the posterior pituitary gland. Oxytocin plays an important role in sexual reproduction of both sexes and is structurally very similar to vasopressin. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320509 [Multi-domain]  Cd Length: 297  Bit Score: 132.25  E-value: 2.54e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 120 LKVYVLAVMALFSLLGNLLTIWNIYKTRisrrnsrHTWSAIYSLMFHLSIADVLVTWFCIIGEAAWCYTVQWLANELTCK 199
Cdd:cd15387    2 VEVTVLALILFLALTGNICVLLAIHTTR-------HKHSRMYFFMKHLSIADLVVAVFQVLPQLIWDITFRFYGPDFLCR 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 200 LVKLFQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLNM-AKRCHRLLggTYILSLVLSLPQFFIFHVAR-GPFVeefYQCv 277
Cdd:cd15387   75 LVKYLQVVGMFASTYMLLLMSIDRCLAICQPLRSLHRrSDRVYVLF--SWLLSLVFSIPQVHIFSLREvGNGV---YDC- 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 278 tHGFYTADWQEQMYATFTLVFTFLLPLCILFGTYMSTfrtissSEKMFQGSKLANYSTAKLPTQTNRQ-----------R 346
Cdd:cd15387  149 -WADFIQPWGPKAYITWITLSVYIIPVLILSVCYGLI------SFKIWQNVKLKTRRETKTPLSSAASggaalarvssvK 221
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 442631927 347 LIHKAKMKSLRISVVIIIAFLICWTP-YYVMMIMFMFLNPDKrlgddlQDAIFFFGM----SNSLVNPLIYGAF 415
Cdd:cd15387  222 LISKAKIRTVKMTFVIVLAYIVCWTPfFFVQMWSVWDPNAPK------EASPFIIAMllasLNSCCNPWIYMFF 289
7tmA_V1bR cd15386
vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
121-419 7.15e-34

vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; The V1b receptor is specifically expressed in corticotropes of the anterior pituitary and plays a critical role in regulating the activity of hypothalamic-pituitary-adrenal axis, a key part of the neuroendocrine system that controls reactions to stress, by maintaining adrenocorticotropic hormone (ACTH) and corticosterone levels. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320508 [Multi-domain]  Cd Length: 302  Bit Score: 131.46  E-value: 7.15e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 121 KVYVLAVMALFSLLGNLLTIWNIYktRISRRNSRhtwsaIYSLMFHLSIADVLVTWFCIIGEAAWCYTVQWLANELTCKL 200
Cdd:cd15386    3 EIGVLAAILVVATAGNLAVLLAMY--RMRRKMSR-----MHLFVLHLALTDLVVALFQVLPQLIWEITYRFQGPDLLCRA 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 201 VKLFQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLNM-AKRCHRLLGGTYILSLVLSLPQFFIF---HVARGPFVeefYQC 276
Cdd:cd15386   76 VKYLQVLSMFASTYMLIMMTVDRYIAVCHPLRTLQQpSRQAYLMIGATWLLSCILSLPQVFIFslrEVDQGSGV---LDC 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 277 -VTHGFytaDWQEQMYATFTLVFTFLLPLCILFGTYMSTFRTISSSEKM-FQGSKLAN--YSTAKLPTQTNRQRLIHKAK 352
Cdd:cd15386  153 wADFGF---PWGAKAYITWTTLSIFVLPVAILIVCYSLICYEICKNLKGkTQTSRSEGggWRTQGMPSRVSSVRTISRAK 229
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 442631927 353 MKSLRISVVIIIAFLICWTPYY-VMMIMFMFLN-PDkrlgDDLQDAIFFFGM----SNSLVNPLIYGAF--HLCP 419
Cdd:cd15386  230 IRTVKMTFVIVLAYIACWAPFFsVQMWSVWDENaPD----EDSSDFAFTITMllasLSSCCNPWIYMFFsgHLLQ 300
7tmA_GPR150 cd15198
G protein-coupled receptor 150, member of the class A family of seven-transmembrane G ...
121-415 3.69e-33

G protein-coupled receptor 150, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors. Its endogenous ligand is not known. These receptors share a significant amino acid sequence similarity, suggesting that they have a common evolutionary origin.


Pssm-ID: 320326 [Multi-domain]  Cd Length: 299  Bit Score: 129.16  E-value: 3.69e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 121 KVYVLAVMALFSLLGNLLTI-WNIYKtriSRRNSRHTwsaiySLMFHLSIADVLVTWFCIIGEAAW-CYTVQWLANELTC 198
Cdd:cd15198    3 RLIFLGVILVAGVAGNTTVLcWLCGG---RRRKSRMN-----FLLLQLALADLLVIGGTALSQIIWeLLGDRWMAGDVAC 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 199 KLVKLFQMFSLYLSTYVLVLIGVDRWIAVKYPMKSlNMAKRCHRLLGgtYILSLVLSLPQFFIFHVARGPFVEEFYQCVT 278
Cdd:cd15198   75 RLLKLLQASARGASANLVVLLALDRHQAIRAPLGQ-PLRAWKLAALG--WLLALLLALPQAYVFRVDFPDDPASAWPGHT 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 279 --HGFYTA--DWQEQMYATFTLVFTFLLPLCILFGTYMSTFRTISSSEKMFQGSKLANYSTAKLPTQTNRQRLIHKAKMK 354
Cdd:cd15198  152 lcRGIFAPlpRWHLQVYATYEAVVGFVAPVVILGVCYGRLLLKWWERANQAPGAKKPWKKPSKSHLRATAPSALPRAKVK 231
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 442631927 355 SLRISVVIIIAFLICWTPYYVMMIMFMFLNPDKrLGDDLQDAIFFFGMSNSLVNPLIYGAF 415
Cdd:cd15198  232 TLKMTLVIALLFVGCSLPYFIAELAAAFGSGDW-EPEKVAAALGVMAVANSATNPFVFLFF 291
7tmA_NPYR-like cd15203
neuropeptide Y receptors and related proteins, member of the class A family of ...
126-413 8.02e-31

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.


Pssm-ID: 320331 [Multi-domain]  Cd Length: 293  Bit Score: 122.33  E-value: 8.02e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 126 AVMALFSLLGNLLTIWNIYKTRiSRRNSRHTwsaiysLMFHLSIADVLVTWFCIIGEAAWCYTVQWLANELTCKLVKLFQ 205
Cdd:cd15203    8 GLIIVLGVVGNLLVIYVVLRNK-SMQTVTNI------FILNLAVSDLLLCLVSLPFTLIYTLTKNWPFGSILCKLVPSLQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 206 MFSLYLSTYVLVLIGVDRWIAVKYPMKSlNMAKR-CHRLLGGTYILSLVLSLPqFFIFHVARGPFVEEFYQCVThgFYTA 284
Cdd:cd15203   81 GVSIFVSTLTLTAIAIDRYQLIVYPTRP-RMSKRhALLIIALIWILSLLLSLP-LAIFQELSDVPIEILPYCGY--FCTE 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 285 DW----QEQMYATFTLVFTFLLPLCILFGTYMSTFRTISSSEKMFQGSKLAnystaklptQTNRQRLIHKAKMKSLRISV 360
Cdd:cd15203  157 SWpsssSRLIYTISVLVLQFVIPLLIISFCYFRISLKLRKRVKKKRGKRTL---------SSRRRRSELRRKRRTNRLLI 227
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 442631927 361 VIIIAFLICWTP---YYVMMIMFMFLNPDKRlgddlQDAIFFF-----GMSNSLVNPLIYG 413
Cdd:cd15203  228 AMVVVFAVCWLPlnlFNLLRDFEPLPQIDGR-----HFYLIFLichliAMSSACVNPLLYG 283
7tmA_V2R cd15388
vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled ...
122-415 2.53e-30

vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The vasopressin type 2 receptor (V2R) is a G(s)-coupled receptor that controls balance of water and sodium ion by regulating their reabsorption in the renal collecting duct. Mutations of V2R is responsible for nephrogenic diabetes insipidus. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320510 [Multi-domain]  Cd Length: 295  Bit Score: 121.03  E-value: 2.53e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 122 VYVLAVMALFSLLGNLLTIWNIYKTRisRRNSRhtwsaIYSLMFHLSIADVLVTWFCIIGEAAWCYTVQWLANELTCKLV 201
Cdd:cd15388    4 IAVLAIIFACALLSNSLVLLVLWRRR--KQLAR-----MHVFMLHLCIADLVVAFFQVLPQLVWDITDRFRGPDVLCRLV 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 202 KLFQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLNM-AKRCHRLLGGTYILSLVLSLPQFFIF-HVARGPFVEEFYQCvth 279
Cdd:cd15388   77 KYLQVVGMFASSYMIVAMTFDRHQAICRPMVTFQKgRARWNGPVCVAWAISLILSLPQVFIFsKVEVAPGVYECWAC--- 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 280 gfYTADWQEQMYATFTLVFTFLLPLCILFGTYMSTFRTI-----SSSEKMFQGSKLANYSTAKlPTQTNRqrlIHKAKMK 354
Cdd:cd15388  154 --FIEPWGLKAYVTWITLVVFVLPTLIITVCQVLIFKEIhiniyLKSQIIVAVVKKKQLLSSR-ASSVAE---VSKAMIK 227
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 442631927 355 SLRISVVIIIAFLICWTPYYVMMiMFMFLNPDKRLGDDLQDAIFFFGMSNSLVNPLIYGAF 415
Cdd:cd15388  228 TVKMTLVIVLVYVLCWAPFFLVQ-LWSVWDPKAPTEGATFTILMLLASLNSCTNPWIYMAF 287
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
124-415 2.26e-29

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 117.28  E-value: 2.26e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 124 VLAVMALFSLLGNLLTIWNIYKTRISRRNSRHtwsaiysLMFHLSIADVLVTWFCIIGEAAWCYTVQWLANELTCKLVKL 203
Cdd:cd14967    5 FLSLIILVTVFGNLLVILAVYRNRRLRTVTNY-------FIVSLAVADLLVALLVMPFSAVYTLLGYWPFGPVLCRFWIA 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 204 FQMFSLYLSTYVLVLIGVDRWIAVKYPM--KSLNMAKRCHRLLGGTYILSLVLSLPQFFIFHVARGPFVEEFYQCVTHGF 281
Cdd:cd14967   78 LDVLCCTASILNLCAISLDRYLAITRPLryRQLMTKKRALIMIAAVWVYSLLISLPPLVGWRDETQPSVVDCECEFTPNK 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 282 YtadwqeqmYATFTLVFTFLLPLCILFGTYMSTFRtISSSEkmfqgsklanystaklptqtnrqrlihkakMKSLRISVV 361
Cdd:cd14967  158 I--------YVLVSSVISFFIPLLIMIVLYARIFR-VARRE------------------------------LKAAKTLAI 198
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 442631927 362 IIIAFLICWTPYYVMMIMFMFlNPDKRLGDDLQDAIFFFGMSNSLVNPLIYGAF 415
Cdd:cd14967  199 IVGAFLLCWLPFFIIYLVSAF-CPPDCVPPILYAVFFWLGYLNSALNPIIYALF 251
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
124-416 4.76e-28

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 114.23  E-value: 4.76e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 124 VLAVMALFSLLGNLLTIWNIYKTRiSRRNSRHTwsaiysLMFHLSIADVLVTWFCIIGEAAWCYTVQWLANELTCKLVKL 203
Cdd:cd14969    6 YLSLIGVLGVVLNGLVIIVFLKKK-KLRTPLNL------FLLNLALADLLMSVVGYPLSFYSNLSGRWSFGDPGCVIYGF 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 204 FQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLNMAKRCH-RLLGGTYILSLVLSLPQFFifhvARGPFVEEFYQCV-THGF 281
Cdd:cd14969   79 AVTFLGLVSISTLAALAFERYLVIVRPLKAFRLSKRRAlILIAFIWLYGLFWALPPLF----GWSSYVPEGGGTScSVDW 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 282 YTADWQEQMYATFTLVFTFLLPLCILFGTYMSTFRTISSSEKMfqgsklanystAKLPTQTNRQRLIHKAKMKSLRISVV 361
Cdd:cd14969  155 YSKDPNSLSYIVSLFVFCFFLPLAIIIFCYYKIYRTLRKMSKR-----------AARRKNSAITKRTKKAEKKVAKMVLV 223
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 442631927 362 IIIAFLICWTPYYVMMIMFMFLNPDKrlgddLQDAIF----FFGMSNSLVNPLIYGAFH 416
Cdd:cd14969  224 MIVAFLIAWTPYAVVSLYVSFGGEST-----IPPLLAtipaLFAKSSTIYNPIIYVFMN 277
7tmA_TACR cd15390
neurokinin receptors (or tachykinin receptors), member of the class A family of ...
124-412 1.99e-25

neurokinin receptors (or tachykinin receptors), member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320512 [Multi-domain]  Cd Length: 289  Bit Score: 106.61  E-value: 1.99e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 124 VLAVMALFSLLGNLLTIWNIYKTRISRRNSRhtwsaiYSLmFHLSIADVLVTWFCIIGEAAWCYTVQWLANELTCKLVKL 203
Cdd:cd15390    6 VFVVMVLVAIGGNLIVIWIVLAHKRMRTVTN------YFL-VNLAVADLLISAFNTVFNFTYLLYNDWPFGLFYCKFSNF 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 204 FQMFSLYLSTYVLVLIGVDRWIAVKYPMKSlNMAKRCHRL-LGGTYILSLVLSLPQFFIFHVARGPFV--EEFYQCVthg 280
Cdd:cd15390   79 VAITTVAASVFTLMAISIDRYIAIVHPLRP-RLSRRTTKIaIAVIWLASFLLALPQLLYSTTETYYYYtgSERTVCF--- 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 281 fytADW-------QEQMYATFTLVFTFLLPLCILFGTYmstfrTISSSEkmFQGSKLANYSTaklPTQTNRQRlihkAKM 353
Cdd:cd15390  155 ---IAWpdgpnslQDFVYNIVLFVVTYFLPLIIMAVAY-----TRVGVE--LWGSKTIGENT---PRQLESVR----AKR 217
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 442631927 354 KSLRISVVIIIAFLICWTPYYVMMIMfMFLNPDKRLGDDLQD---AIFFFGMSNSLVNPLIY 412
Cdd:cd15390  218 KVVKMMIVVVVIFAICWLPYHLYFIL-TYLYPDINSWKYIQQiylAIYWLAMSNSMYNPIIY 278
7tmA_NPFFR cd15207
neuropeptide FF receptors, member of the class A family of seven-transmembrane G ...
130-415 9.87e-25

neuropeptide FF receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320335 [Multi-domain]  Cd Length: 291  Bit Score: 104.63  E-value: 9.87e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 130 LFSLLGNLLTIWNIYKTRisrrnsrHTWSAIYSLMFHLSIADVLVTWFCI-------IgeaawcyTVQWLANELTCKLVK 202
Cdd:cd15207   12 LLCVVGNVLVCLVVAKNP-------RMRTVTNYFILNLAVSDLLVGVFCMpftlvdnI-------LTGWPFGDVMCKLSP 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 203 LFQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLNMAKRCHRLLGGTYILSLVLSLPQFFIFHVARgpfvEEFYQCVTHGFY 282
Cdd:cd15207   78 LVQGVSVAASVFTLVAIAVDRYRAVVHPTEPKLTNRQAFVIIVAIWVLALAIMIPQALVLEVKE----YQFFRGQTVHIC 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 283 TADWQE----QMYATFTLVFTFLLPLCILFGTYMSTFRTISSSEKMFQGSKlanystaklptQTNRQRLIHKAKMKSLRI 358
Cdd:cd15207  154 VEFWPSdeyrKAYTTSLFVLCYVAPLLIIAVLYVRIGYRLWFKPVPGGGSA-----------SREAQAAVSKKKVRVIKM 222
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 442631927 359 SVVIIIAFLICWTPYYVmmimFMFLNPDKRLGDDLQDAIFFF--------GMSNSLVNPLIYGAF 415
Cdd:cd15207  223 LIVVVVLFALSWLPLHT----VTMLDDFGNLSPNQREVLYVYiypiahwlAYFNSCVNPIVYGYF 283
7tmA_PR4-like cd15392
neuropeptide Y receptor-like found in insect and related proteins, member of the class A ...
126-412 1.54e-24

neuropeptide Y receptor-like found in insect and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a novel G protein-coupled receptor (also known as PR4 receptor) from Drosophila melanogaster, which can be activated by the members of the neuropeptide Y (NPY) family, including NPY, peptide YY (PYY) and pancreatic polypeptide (PP), when expressed in Xenopus oocytes. These homologous peptides of 36-amino acids in length contain a hairpin-like structural motif, which referred to as the pancreatic polypeptide fold, and function as gastrointestinal hormones and neurotransmitters. The PR4 receptor also shares strong sequence homology to the mammalian tachykinin receptors (NK1R, NK2R, and NK3R), whose endogenous ligands are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), respectively. The tachykinins function as excitatory transmitters on neurons and cells in the gastrointestinal tract.


Pssm-ID: 320514 [Multi-domain]  Cd Length: 287  Bit Score: 103.98  E-value: 1.54e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 126 AVMALFSLLGNLLTIWNIYKTRISRrnsrhtwSAIYSLMFHLSIADVLVTWFCI-IGEAAWCYTVQWLANELTCKLVKLF 204
Cdd:cd15392    8 STIFVLAVGGNGLVCYIVVSYPRMR-------TVTNYFIVNLALSDILMAVFCVpFSFIALLILQYWPFGEFMCPVVNYL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 205 QMFSLYLSTYVLVLIGVDRWIAVKYPMKSLNMAKRCHRLLGGTYILSLVLSLPQFFIFHVargpFVEEFYQCVThGFYTA 284
Cdd:cd15392   81 QAVSVFVSAFTLVAISIDRYVAIMWPLRPRMTKRQALLLIAVIWIFALATALPIAITSRL----FEDSNASCGQ-YICTE 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 285 DW----QEQMYATFTLVFTFLLPLCILFGTYMSTFRTISSSekmfqgsklanystaKLP--TQTNRQRLIHKAKMKSLRI 358
Cdd:cd15392  156 SWpsdtNRYIYSLVLMILQYFVPLAVLVFTYTRIGIVVWAK---------------RTPgeAENNRDQRMAESKRKLVKM 220
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 442631927 359 SVVIIIAFLICWTPYYVMMImFMFLNPDKRLGDDLQDAIFFF---GMSNSLVNPLIY 412
Cdd:cd15392  221 MITVVAIFALCWLPLNILNL-VGDHDESIYSWPYIPYLWLAAhwlAMSHCCYNPFIY 276
7tmA_TACR-like cd15202
tachykinin receptors and related receptors, member of the class A family of ...
127-412 7.00e-24

tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320330 [Multi-domain]  Cd Length: 288  Bit Score: 102.20  E-value: 7.00e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 127 VMALFSLLGNLLTIWNIYKTRISRrnsrhtwSAIYSLMFHLSIADVLVTWFCIIGEAAWCYTVQWLANELTCKLVKLFQM 206
Cdd:cd15202    9 FIIVFSLFGNVLVCWIIFKNQRMR-------TVTNYFIVNLAVADIMITLFNTPFTFVRAVNNTWIFGLFMCHFSNFAQY 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 207 FSLYLSTYVLVLIGVDRWIAVKYPMKSLNMAKRCHRLLGGTYILSLVLSLPQ-----FFIFHVARGPfveEFYQCVTHGF 281
Cdd:cd15202   82 CSVHVSAYTLTAIAVDRYQAIMHPLKPRISKTKAKFIIAVIWTLALAFALPHaicskLETFKYSEDI---VRSLCLEDWP 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 282 YTADWQEQMYATFTLVFTFLLPLCILFGTYMSTFRTISSSEKMFQgsklanystaklpTQTNRQRLIHKAKMKSLRISVV 361
Cdd:cd15202  159 ERADLFWKYYDLALFILQYFLPLLVISFAYARVGIKLWASNMPGD-------------ATTERYFALRRKKKKVIKMLMV 225
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 442631927 362 IIIAFLICWTPYYVMMIMfMFLNPD--KRLGDDLQDAIFFFGMSNSLVNPLIY 412
Cdd:cd15202  226 VVVLFALCWLPFNIYVLL-LSSKPDylIKTINAVYFAFHWLAMSSTCYNPFIY 277
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
122-415 9.81e-24

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 101.94  E-value: 9.81e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 122 VYVLAVMALFSLLGNLLTIWnIYkTRISRRNSrhtwsaIYSLMFHLSIADVLVTWFCII--------GEAAWCYTVQWLa 193
Cdd:cd14978    4 GYVLPVICIFGIIGNILNLV-VL-TRKSMRSS------TNVYLAALAVSDILVLLSALPlfllpyiaDYSSSFLSYFYA- 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 194 neLTCKLVKLFQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLNMA--KRCHRLLGGTYILSLVLSLPQFFIFHV---ARGP 268
Cdd:cd14978   75 --YFLPYIYPLANTFQTASVWLTVALTVERYIAVCHPLKARTWCtpRRARRVILIIIIFSLLLNLPRFFEYEVvecENCN 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 269 FVEEFYQCVTHGFYTADWQEQMYATFTLVFTFLLPLCILFGTYMSTFRTISSSEKMfqgsklanystAKLPTQTNRQRLI 348
Cdd:cd14978  153 NNSYYYVIPTLLRQNETYLLKYYFWLYAIFVVLLPFILLLILNILLIRALRKSKKR-----------RRLLRRRRRLLSR 221
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 442631927 349 HKAK-MKSLRISVVIIIAFLICWTPYYVMMIMFMFlnpdkrLGDDLQDAIF--------FFGMSNSLVNPLIYGAF 415
Cdd:cd14978  222 SQRReRRTTIMLIAVVIVFLICNLPAGILNILEAI------FGESFLSPIYqllgdisnLLVVLNSAVNFIIYCLF 291
7tmA_Histamine_H3R_H4R cd15048
histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G ...
124-416 1.05e-23

histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H4R, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320176 [Multi-domain]  Cd Length: 296  Bit Score: 101.61  E-value: 1.05e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 124 VLAVMALFSLLGNLLTIWNIyktrISRRNSRHTwSAIYslMFHLSIADVLVTWFCIIGEAAWCYTVQWLANELTCKLVKL 203
Cdd:cd15048    6 LISVLILVTVIGNLLVILAF----IKDKKLRTV-SNFF--LLNLAVADFLVGLVSMPFYIPYTLTGKWPFGKVFCKAWLV 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 204 FQMFSLYLSTYVLVLIGVDRWIAVKYPMK--SLNMAKRCHRLLGGTYILSLVLSLPQFFIFHVARGPFVEEFYQCVthgf 281
Cdd:cd15048   79 VDYTLCTASALTIVLISLDRYLSVTKAVKyrAKQTKRRTVLLMALVWILAFLLYGPAIIGWDLWTGYSIVPTGDCE---- 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 282 ytADWQEQMYATFTL-VFTFLLPLCILFGTYMSTFRTI--SSSEKMFQGSKLANYSTAKLPTQTNRQRLIHKAKMKSLRI 358
Cdd:cd15048  155 --VEFFDHFYFTFITsVLEFFIPFISVSFFNLLIYLNIrkRSRRRPLRSVPILPASQNPSRARSQREQVKLRRDRKAAKS 232
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 442631927 359 SVVIIIAFLICWTPYYVMMIMFMFLNpDKRLGDDLQDAIFFFGMSNSLVNPLIYGAFH 416
Cdd:cd15048  233 LAILVLVFLICWAPYTILTIIRSFCS-GSCVDSYLYEFTFWLLWTNSAINPFLYAACH 289
7tmA_CXCR1_2 cd15178
CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G ...
118-415 2.51e-23

CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR1 and CXCR2 are closely related chemotactic receptors for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. Expression of CXCR1 and CXCR2 is strictly controlled in neutrophils by external stimuli such as lipopolysaccharide (LPS), tumor necrosis factor (TNF)-alpha, Toll-like receptor agonists, and nitric oxide. CXCL8 (formerly known as interleukin-8) binds with high-affinity and activates both receptors. CXCR1 also binds CXCL7 (neutrophil-activating protein-2), whereas CXCR2 non-selectively binds to all seven ELR-positive chemokines (CXCL1-7). Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341333 [Multi-domain]  Cd Length: 279  Bit Score: 100.43  E-value: 2.51e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 118 GLLKVYVLavMALFSLLGNLLTIWNIYKTRISRrnsrhTWSAIYslMFHLSIADVLvtwFCIIGEAAWCYTV-QWLANEL 196
Cdd:cd15178    2 ALCVIYVL--VFLLSLPGNSLVVLVILYNRRSR-----SSTDVY--LLHLAIADLL---FALTLPFWAVSVVkGWIFGTF 69
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 197 TCKLVKLFQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLNMAKRCHRLL-GGTYILSLVLSLPQFFIFHVARGPfveEFYQ 275
Cdd:cd15178   70 MCKLVSLLQEANFYSGILLLACISVDRYLAIVHATRALTQKRHLVKFVcAGVWLLSLLLSLPALLNRDAFKPP---NSGR 146
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 276 CVTHGFYTADWQEQMYATFTL---VFTFLLPLCILFGTYMSTFRTISSSeKMFQgsklanystaklptqtnrqrlihkaK 352
Cdd:cd15178  147 TVCYENLGNESADKWRVVLRIlrhTLGFLLPLVVMLFCYGFTIKTLLQT-RSFQ-------------------------K 200
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 442631927 353 MKSLRISVVIIIAFLICWTPYYVMMIM--FM---FLNPDKRLGDDLQDAIFF---FGMSNSLVNPLIYgAF 415
Cdd:cd15178  201 HRAMRVIFAVVLAFLLCWLPYNVTVLIdtLMrtkLITETCELRNHVDVALYVtqiLGFLHSCINPVLY-AF 270
7tmA_GPRnna14-like cd15001
GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...
122-413 4.39e-23

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320132 [Multi-domain]  Cd Length: 266  Bit Score: 99.27  E-value: 4.39e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 122 VYVLAVmaLFSLLGNLLTIWNIYKTRISRrnsrhtwSAIYSLMFHLSIADVLVTWFCIIGEAAWCYTVQWLANELTCKLV 201
Cdd:cd15001    5 VYVITF--VLGLIGNSLVIFVVARFRRMR-------SVTNVFLASLATADLLLLVFCVPLKTAEYFSPTWSLGAFLCKAV 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 202 KLFQMFSLYLSTYVLVLIGVDRWIAVKYPMK--SLNMAKRCHRLLGGTYILSLVLSLPQFFIFHVARGPFVEEFYQCVTH 279
Cdd:cd15001   76 AYLQLLSFICSVLTLTAISIERYYVILHPMKakSFCTIGRARKVALLIWILSAILASPVLFGQGLVRYESENGVTVYHCQ 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 280 GFYTADWQEQMYATFTLVFTFLLPLCILFGTYMStfrtisssekmfqgsklanystaklptqTNRQRLIhkaKMkslriS 359
Cdd:cd15001  156 KAWPSTLYSRLYVVYLAIVIFFIPLIVMTFAYAR----------------------------DTRKQVI---KM-----L 199
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 442631927 360 VVIIIAFLICWTPYYVMMIMFMFL---NPDKRLGDDLQDAIFFFGMSNSLVNPLIYG 413
Cdd:cd15001  200 ISVVVLFAVCWGPLLIDNLLVSFDvisTLHTQALKYMRIAFHLLSYANSCINPIIYA 256
7tmA_OXR cd15208
orexin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
130-412 4.85e-23

orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Orexins (OXs, also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. Thus, activation of OX1R or OX2R will activate phospholipase activity and the phosphatidylinositol and calcium signaling pathways. Additionally, OX2R activation can also lead to inhibition of adenylate cyclase.


Pssm-ID: 320336 [Multi-domain]  Cd Length: 303  Bit Score: 100.16  E-value: 4.85e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 130 LFSLLGNLLTIWNIYKTRISRrnsrhTWSAIYslMFHLSIADVLVTWFCIIGEAAWCYTVQWLANELTCKLVKLFQMFSL 209
Cdd:cd15208   12 IVGLVGNVLVCFAVWRNHHMR-----TVTNYF--IVNLSLADFLVIIICLPATLLVDVTETWFFGQVLCKIIPYLQTVSV 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 210 YLSTYVLVLIGVDRWIAVKYPMKSLNMAKRCHRLLGGTYILSLVLSLPQFFIF----HVARGPFVEEFYQCVTHgfYTAD 285
Cdd:cd15208   85 SVSVLTLSCIALDRWYAICHPLMFKSTAKRARVSILIIWIVSLLIMIPQAIVMecsrVVPLANKTILLTVCDER--WSDS 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 286 WQEQMYATFTLVFTFLLPLCILFGTYMSTFRTISSSEKMFQGSKLANYSTAKLPTQTNRQRLIHKAKMKSLRISVVIIIA 365
Cdd:cd15208  163 IYQKVYHICFFLVTYLLPLCLMILAYFQIFRKLWCRQIPGTSSVVQRKWNKPRKSAVAAEEKQLRSRRKTAKMLIVVVIM 242
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 442631927 366 FLICWTPYYVMMIM----FMFLNpdkrlgdDLQDAIFFFGMS------NSLVNPLIY 412
Cdd:cd15208  243 FAICYLPVHLLNILryvfGLFTV-------DRETIYAWFLFShwlvyaNSAINPIIY 292
7tmA_NPR-like_invertebrate cd15391
invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G ...
132-413 4.99e-23

invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor found in invertebrates, which is a member of class A of 7-transmembrane G protein-coupled receptors. This orphan receptor shares a significant amino acid sequence identity with the neurokinin 1 receptor (NK1R). The endogenous ligand for NK1R is substance P, an 11-amino acid peptide that functions as a vasodilator and neurotransmitter and is released from the autonomic sensory nerve fibers.


Pssm-ID: 320513 [Multi-domain]  Cd Length: 289  Bit Score: 99.51  E-value: 4.99e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 132 SLLGNLLTIWNIYKTRISRrnsrhtwSAIYSLMFHLSIADVLVTWFCIIGEAAWCYTVQWLANELTCKLVKLFQMFSLYL 211
Cdd:cd15391   14 SVGGNYSVIVVFYDGRRSR-------TDLNYYLINLAVSDLIMALFCMPFTFTQIMLGHWVFPAPMCPIVLYVQLVSVTA 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 212 STYVLVLIGVDRWIAVKYPMKSLNMAKRCHRLLGGTYILSLVLSLPQFFIFHVARGPFVEEFYQCVTHGFYTADWQEQMY 291
Cdd:cd15391   87 SVLTNTAIGIDRFFAVIFPLRSRHTKSRTKCIIASIWAISFSLSSVQLFAGRTQRYGQYSEGRVLCGESWPGPDTSRSAY 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 292 ATFTLVFTFLLPLCILFGTYmstfrtisssekMFQGSKLANySTAKLPTQTNRQRLIHKAKMKSLRISVVIIIAFLICWT 371
Cdd:cd15391  167 TVFVMLLTYIIPLLILTSTY------------GYVGFRLWN-RTAPGNADKGRDDMQIKSKRKVIKMLVFVVLMFGICWL 233
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 442631927 372 PYYVMMIMFMFLNPDKRLGDDLQDAIF----FFGMSNSLVNPLIYG 413
Cdd:cd15391  234 PLHLFNLVQDFSTVFRNMPQHTTRLIYgachWIAMSNSFVNPIIYL 279
7tmA_Melanopsin-like cd15083
vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...
124-416 7.10e-23

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320211 [Multi-domain]  Cd Length: 291  Bit Score: 99.33  E-value: 7.10e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 124 VLAVMALFSLLGNLLTIWNIYKTRISRRNSrhtwsaiYSLMFHLSIADVLvtwFCIIGE---AAWCYTVQWLANELTCKL 200
Cdd:cd15083    6 FILIIGLIGVVGNGLVIYAFCRFKSLRTPA-------NYLIINLAISDFL---MCILNCplmVISSFSGRWIFGKTGCDM 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 201 VKLFQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLnmAKRCHRL----LGGTYILSLVLSLPQFFifhvARGPFVEEFYQC 276
Cdd:cd15083   76 YGFSGGLFGIMSINTLAAIAVDRYLVITRPMKAS--VRISHRRalivIAVVWLYSLLWVLPPLF----GWSRYVLEGLLT 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 277 -VTHGFYTADWQEQMYATFTLVFTFLLPLCILFGTYMSTFRTISSSEKMFQGSKLANYSTAKLPTQTNRQRLIHKAKmks 355
Cdd:cd15083  150 sCSFDYLSRDDANRSYVICLLIFGFVLPLLIIIYCYSFIFRAVRRHEKAMKEMAKRFSKSELSSPKARRQAEVKTAK--- 226
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 442631927 356 lrISVVIIIAFLICWTPYYVMMIMFMFLNPDKRLGDDLQDAIFFFGMSnSLVNPLIYGAFH 416
Cdd:cd15083  227 --IALLLVLLFCLAWTPYAVVALIGQFGYLEVLTPLATAIPAAFAKTS-AIYNPVIYAFSH 284
7tmA_PrRP_R cd15394
prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
126-416 9.33e-23

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prolactin-releasing peptide (PrRP) receptor (previously known as GPR10) is expressed in the central nervous system with the highest levels located in the anterior pituitary and is activated by its endogenous ligand PrRP, a neuropeptide possessing a C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acids (PrRP-20) and the other consists of 31 amino acids (PrRP-31), where PrRP-20 is a C-terminal fragment of PrRP-31. Binding of PrRP to the receptor coupled to G(i/o) proteins activates the extracellular signal-related kinase (ERK) and it can also couple to G(q) protein leading to an increase in intracellular calcium and activation of c-Jun N-terminal protein kinase (JNK). The PrRP receptor shares significant sequence homology with the neuropeptide Y (NPY) receptor, and micromolar levels of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors. PrRP has been shown to reduce food intake and body weight and modify body temperature when administered in rats. It also has been shown to decrease circulating growth hormone levels by activating somatostatin-secreting neurons in the hypothalamic periventricular nucleus.


Pssm-ID: 320516 [Multi-domain]  Cd Length: 286  Bit Score: 98.66  E-value: 9.33e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 126 AVMALFSLLGNLLTIWNIYKTRisrrnSRHtwSAIYSLMFHLSIADVLVTWFCIIGEAAWCYTVQ-WLANELTCKLVKLF 204
Cdd:cd15394    8 SLVVLVGVVGNYLLIYVICRTK-----KMH--NVTNFLIGNLAFSDMLMCATCVPLTLAYAFEPRgWVFGRFMCYFVFLM 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 205 QMFSLYLSTYVLVLIGVDRWIAVKYPMKSLNMAKRCHRLLGGTYILSLVLSLPQffIFHVARGPFVE-EFYQCvtHGFYT 283
Cdd:cd15394   81 QPVTVYVSVFTLTAIAVDRYYVTVYPLRRRISRRTCAYIVAAIWLLSCGLALPA--AAHTYYVEFKGlDFSIC--EEFWF 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 284 ADWQEQM-YATFTLVFTFLLPLCILFGTYMSTfrtisssekmfqGSKLANYSTAKLPTQTNRQRLiHKAKMKSLRISVVI 362
Cdd:cd15394  157 GQEKQRLaYACSTLLITYVLPLLAISLSYLRI------------SVKLRNRVVPGSMTQSQAEWD-RARRRKTFRLLVVV 223
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 442631927 363 IIAFLICWTPYYVMMIMfMFLNP---DKRLGDDLQDAIFFFGMSNSLVNPLIYGAFH 416
Cdd:cd15394  224 VVAFAICWLPLHIFNVI-RDIDIdliDKQYFNLIQLLCHWLAMSSACYNPFLYAWLH 279
7tmA_leucokinin-like cd15393
leucokinin-like peptide receptor from tick and related proteins, member of the class A family ...
126-413 1.17e-22

leucokinin-like peptide receptor from tick and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a leucokinin-like peptide receptor from the Southern cattle tick, Boophilus microplus, a pest of cattle world-wide. Leucokinins are invertebrate neuropeptides that exhibit myotropic and diuretic activity. This receptor is the first neuropeptide receptor known from the Acari and the second known in the subfamily of leucokinin-like peptide G-protein-coupled receptors. The other known leucokinin-like peptide receptor is a lymnokinin receptor from the mollusc Lymnaea stagnalis.


Pssm-ID: 320515 [Multi-domain]  Cd Length: 288  Bit Score: 98.63  E-value: 1.17e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 126 AVMALFSLLGNLLTIWNIYKTRisrrnSRHTWSAIYSLmfHLSIADVLVTWFCIIGEAAWCYTVQWLANELTCKLVKLFQ 205
Cdd:cd15393    8 GIISLVAVVGNFLVIWVVAKNR-----RMRTVTNIFIA--NLAVADIIIGLFSIPFQFQAALLQRWVLPRFMCPFCPFVQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 206 MFSLYLSTYVLVLIGVDRWIAVKYPMKSLNMAKRCHRLLGGTYILSLVLSLPQFFIFHVARgpFVEEFY-----QCVTHG 280
Cdd:cd15393   81 VLSVNVSVFTLTVIAVDRYRAVIHPLKARCSKKSAKIIILIIWILALLVALPVALALRVEE--LTDKTNngvkpFCLPVG 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 281 FyTADWQeQMYATFTLVFTFLLPLCILFGTYMSTFRTISSSekmfqgsklanystaKLPTQTNRQRLIH--KAKMKSLRI 358
Cdd:cd15393  159 P-SDDWW-KIYNLYLVCVQYFVPLVIICYAYTRIAVKIWGT---------------KAPGNAQDVRDDEilKNKKKVIKM 221
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 442631927 359 SVVIIIAFLICWTPYYVMMIMFmFLNPdKRLGDDLQDAIFFF----GMSNSLVNPLIYG 413
Cdd:cd15393  222 LIIVVALFALCWLPLQTYNLLN-EIKP-EINKYKYINIIWFCshwlAMSNSCYNPFIYG 278
7tmA_AstA_R_insect cd15096
allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G ...
124-412 2.29e-22

allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled AstA receptor binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320224 [Multi-domain]  Cd Length: 284  Bit Score: 97.75  E-value: 2.29e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 124 VLAVMALFSLLGNLLTIwniykTRISRRNSRHTWSAIysLMFHLSIADVLVTWFCIIGEAAWCYTVQWLANELTCKLVKL 203
Cdd:cd15096    6 IFGLIFIVGLIGNSLVI-----LVVLSNQQMRSTTNI--LILNLAVADLLFVVFCVPFTATDYVLPTWPFGDVWCKIVQY 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 204 FQMFSLYLSTYVLVLIGVDRWIAVKYPMKSlnMAKRCHR----LLGGTYILSLVLSLPQFFIFHVARGPFVEEFYQCVTH 279
Cdd:cd15096   79 LVYVTAYASVYTLVLMSLDRYLAVVHPITS--MSIRTERntliAIVGIWIVILVANIPVLFLHGVVSYGFSSEAYSYCTF 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 280 GFYTADWQEQMYATFtLVFTFLLPLCILFGTYMSTFRTIsssekMFQGSKLANYSTAKlptqtnrqrliHKAKMKSLRIS 359
Cdd:cd15096  157 LTEVGTAAQTFFTSF-FLFSYLIPLTLICVLYMLMLRRL-----RRQKSPGGRRSAES-----------QRGKRRVTRLV 219
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 442631927 360 VVIIIAFLICWTPYYVMMIM-FMFLNPDKRLGDDLQDAIFFFGMSNSLVNPLIY 412
Cdd:cd15096  220 VVVVVVFAICWLPIHIILLLkYYGVLPETVLYVVIQILSNCLAYGNSCVNPILY 273
7tmA_purinoceptor-like cd14982
purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...
122-412 4.34e-22

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341318 [Multi-domain]  Cd Length: 283  Bit Score: 96.57  E-value: 4.34e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 122 VYVLAVmaLFSLLGNLLTIWnIYKTRISRRNSrhtwSAIYslMFHLSIADVLVTW---FCIIgeaawcYTVQ---WLANE 195
Cdd:cd14982    6 VYSLIF--ILGLLGNILALW-VFLRKMKKRSP----TTIY--MINLALADLLFVLtlpFRIY------YYLNggwWPFGD 70
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 196 LTCKLVKLFQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLNMAKRCHRLL--GGTYILSLVLSLPqFFIFHvARGPFVEEF 273
Cdd:cd14982   71 FLCRLTGLLFYINMYGSILFLTCISVDRYLAVVHPLKSRRLRRKRYAVGvcAGVWILVLVASVP-LLLLR-STIAKENNS 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 274 YQC-VTHGFYTADWQEqmYATFTLVFTFLLPLCILFGTYMSTFRTISSSEKMFQGSKLanystaklptqtnrqrlihkaK 352
Cdd:cd14982  149 TTCfEFLSEWLASAAP--IVLIALVVGFLIPLLIILVCYSLIIRALRRRSKQSQKSVR---------------------K 205
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 442631927 353 MKSLRISVVIIIAFLICWTPYYVMMIMFMFLNPDKRLGDDLQDAIFFF-------GMSNSLVNPLIY 412
Cdd:cd14982  206 RKALRMILIVLAVFLVCFLPYHVTRILYLLVRLSFIADCSARNSLYKAyritlclASLNSCLDPLIY 272
7tmA_Opioid_R-like cd14970
opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...
124-413 6.82e-22

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.


Pssm-ID: 320101 [Multi-domain]  Cd Length: 282  Bit Score: 96.21  E-value: 6.82e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 124 VLAVMALFSLLGNLLTIwniykTRISRRNSRHTWSAIYslMFHLSIADVLVTwfCIIGEAAWCYTVQ-WLANELTCKLVK 202
Cdd:cd14970    6 VYSVVCVVGLTGNSLVI-----YVILRYSKMKTVTNIY--ILNLAVADELFL--LGLPFLATSYLLGyWPFGEVMCKIVL 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 203 LFQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLNM--AKRCHRLLGGTYILSLVLSLPqFFIFHVARgPFVEEFYQCVTHG 280
Cdd:cd14970   77 SVDAYNMFTSIFCLTVMSVDRYLAVVHPVKSLRFrtPRKAKLVSLCVWALSLVLGLP-VIIFARTL-QEEGGTISCNLQW 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 281 FYTADWQEQMYATFTLVFTFLLPLCILFGTYMSTFRTISSSEKMFQGSklanystaklptqtnrQRLIHKAKMKSLRISV 360
Cdd:cd14970  155 PDPPDYWGRVFTIYTFVLGFAVPLLVITVCYSLIIRRLRSSRNLSTSG----------------AREKRRARRKVTRLVL 218
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 442631927 361 VIIIAFLICWTPYYVMMIMFMFLNPDKrlgDDLQDAIFFF----GMSNSLVNPLIYG 413
Cdd:cd14970  219 VVVAVFVVCWLPFHVFQIVRLLIDPPE---TLTVVGVFLFcialSYANSCLNPILYA 272
7tmA_prokineticin-R cd15204
prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
163-415 1.45e-21

prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Prokineticins 1 (PROK1) and 2 (PROK2), also known as endocrine gland vascular endothelial factor and Bombina varigata 8, respectively, are multifunctional chemokine-like peptides that are highly conserved across species. Prokineticins can bind with similar affinities to two closely homologous 7-transmembrane G protein coupled receptors, PROKR1 and PROKR2, which are phylogenetically related to the tachykinin receptors. Prokineticins and their GPCRs are widely distributed in human tissues and are involved in numerous physiological roles, including gastrointestinal motility, generation of circadian rhythms, neuron migration and survival, pain sensation, angiogenesis, inflammation, and reproduction. Moreover, different point mutations in genes encoding PROK2 or its receptor (PROKR2) can lead to Kallmann syndrome, a disease characterized by delayed or absent puberty and impaired olfactory function.


Pssm-ID: 320332 [Multi-domain]  Cd Length: 288  Bit Score: 95.42  E-value: 1.45e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 163 LMFHLSIADVLVTWFCIIGEAAWcYTVQ---WLANELTCKLVKLFQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLNMAKR 239
Cdd:cd15204   38 LIANLALSDFLVAVFCLPFEMDY-YVVRqrsWTHGDVLCAVVNYLRTVSLYVSTNALLVIAIDRYLVIVHPLKPRMKRRT 116
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 240 CHRLLGGTYILSLVLSLPqffifhVARgpFVEEFYQCVTHGFYTAD----WQEQMYATFTL---VFTFLLPLCILFGTYM 312
Cdd:cd15204  117 ACVVIALVWVVSLLLAIP------SAV--YSKTTPYANQGKIFCGQiwpvDQQAYYKAYYLflfVLEFVLPVLIMTLCYL 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 313 STFRTIssSEKMFQGsklanystaklpTQTNRQRLIHKAKMKSLRISVVIIIAFLICWTPYYVMMIMFMFLnPDKRLGDD 392
Cdd:cd15204  189 RIVRKV--WFRRVPG------------QQTEQIRRRLRRRRRKVRLLVVILTAFVLCWAPYYGYAIVRDFF-PTLLSKEK 253
                        250       260
                 ....*....|....*....|....*..
gi 442631927 393 LQDAIFF----FGMSNSLVNPLIYGAF 415
Cdd:cd15204  254 LNTTIFYiveaLAMSNSMINTVVYVAF 280
7tmA_QRFPR cd15205
pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane ...
119-412 1.63e-21

pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that belongs to a family of neuropeptides containing an Arg-Phe-NH2 (RFamide) motif at its C-terminus. 26Rfa/QRFP exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103.


Pssm-ID: 320333 [Multi-domain]  Cd Length: 298  Bit Score: 95.23  E-value: 1.63e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 119 LLKVYVLA-VMALFsllGNLLTIWNIYKTRISRrnsrhtwSAIYSLMFHLSIADVLVTWFCIIGEAAWCYTVQWLANELT 197
Cdd:cd15205    3 FVITYVLIfVLALF---GNSLVIYVVTRKRAMR-------TATNIFICSLALSDLLITFFCIPFTLLQNISSNWLGGAFM 72
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 198 CKLVKLFQMFSLYLSTYVLVLIGVDRWIAVKYP--MKSLNMAKRCHRLLGGTYILSLVLSLPQFFI--FHVARGPFVEEF 273
Cdd:cd15205   73 CKMVPFVQSTAVVTSILTMTCIAVERHQGIVHPlkMKWQYTNRRAFTMLGLVWIVSVIVGSPMLFVqqLEVKYDFLYEKR 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 274 YQCVTHGFYTADwQEQMYATFTLVFTFLLPLCILFGTYMSTFRTISSSEKMFQGSKLA---NYSTAKlptqtnrqrlIHK 350
Cdd:cd15205  153 HVCCLERWYSPT-QQKIYTTFILVILFLLPLTTMLFLYSRIGYELWIKKRVGDASVLQtihGIEMSK----------ISR 221
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 442631927 351 AKMKSLRISVVIIIAFLICWTPYYVMMIMFMFLNPDKRLGDDLQDAIF----FFGMSNSLVNPLIY 412
Cdd:cd15205  222 KKKRAVKMMVTVVLLFAVCWAPFHVVHMMIEYSNLENKYDGVTIKLIFaivqLIGFSNSFNNPIVY 287
7tmA_Chemokine_R cd14984
classical and atypical chemokine receptors, member of the class A family of ...
130-415 2.74e-21

classical and atypical chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. In addition to these classical chemokine receptors, there exists a subfamily of atypical chemokine receptors (ACKRs) that are unable to couple to G-proteins and, instead, they preferentially mediate beta-arrestin dependent processes, such as receptor internalization, after ligand binding. The classical chemokine receptors contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. However, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 341319 [Multi-domain]  Cd Length: 278  Bit Score: 94.20  E-value: 2.74e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 130 LFSLLGNLLTIWniykTRISRRNSRHTwSAIYslMFHLSIADVLvtWFCIIGEAAWCYTVQWLANELTCKLVKLFQMFSL 209
Cdd:cd14984   12 LLGLVGNSLVLL----VLLYYRKLRSM-TDVY--LLNLALADLL--FVLTLPFWAVYAADGWVFGSFLCKLVSALYTINF 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 210 YLSTYVLVLIGVDRWIAVKYPMKSLNMAKRCHRLL--GGTYILSLVLSLPQFfIFHvaRGPFVEEFYQCvtHGFYTADWQ 287
Cdd:cd14984   83 YSGILFLACISIDRYLAIVHAVSALRARTLLHGKLtcLGVWALALLLSLPEF-IFS--QVSEENGSSIC--SYDYPEDTA 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 288 EQMYATFTL---VFTFLLPLCILFGTYMSTFRTISSSEkmfqgsklanystaklptqtnrqrliHKAKMKSLRISVVIII 364
Cdd:cd14984  158 TTWKTLLRLlqnILGFLLPLLVMLFCYSRIIRTLLRAR--------------------------NHKKHRALRVIFAVVV 211
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 442631927 365 AFLICWTPYYVMMIM-----FMFLNPDKRLGDDLQDAIFF---FGMSNSLVNPLIYgAF 415
Cdd:cd14984  212 VFFLCWLPYNIVLLLdtlqlLGIISRSCELSKSLDYALQVtesLAFSHCCLNPVLY-AF 269
7tmA_Gal1_R cd15098
galanin receptor subtype 1, member of the class A family of seven-transmembrane G ...
122-415 6.04e-21

galanin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320226 [Multi-domain]  Cd Length: 282  Bit Score: 93.25  E-value: 6.04e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 122 VYVLAVMAL-FSL--LGNLLTIWNIYKTRISRRNSRhtwSAIYSLmfHLSIADVLVTWFCIIGEAAWCYTVQWLANELTC 198
Cdd:cd15098    1 VIVPVVFGLiFCLgvLGNSLVITVLARVKPGKRRST---TNVFIL--NLSIADLFFLLFCVPFQATIYSLPEWVFGAFMC 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 199 KLVKLFQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLNMAKRCHRLLGGTYI--LSLVLSLPQFFIFHVARGPFVEEFYQC 276
Cdd:cd15098   76 KFVHYFFTVSMLVSIFTLVAMSVDRYIAVVHSRTSSSLRTRRNALLGVLVIwvLSLAMASPVAVHQDLVHHWTASNQTFC 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 277 VTHGFYTAdwQEQMYATFTLVFTFLLPLCILFGTYMSTFRTISSseKMFQGSKLANYStaklptqtnrqrlihkaKMKSL 356
Cdd:cd15098  156 WENWPEKQ--QKPVYVVCTFVFGYLLPLLLITFCYAKVLNHLHK--KLKNMSKKSERS-----------------KKKTA 214
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 442631927 357 RISVVIIIAFLICWTPYYVMMIMFMFlnpdkrlGD-DLQDAIFFF-------GMSNSLVNPLIYgAF 415
Cdd:cd15098  215 QTVLVVVVVFGISWLPHHIIHLWVEF-------GDfPLTQASFVLritahclAYANSCVNPIIY-AF 273
7tmA_TACR_family cd14992
tachykinin receptor and closely related proteins, member of the class A family of ...
125-412 2.41e-20

tachykinin receptor and closely related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family as well as closely related receptors. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320123 [Multi-domain]  Cd Length: 291  Bit Score: 91.73  E-value: 2.41e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 125 LAVMALFSLLGNLLTIWNIYKTRISRrnsrhtwSAIYSLMFHLSIADVLVTWFCIIGEAAWCYTVQWLANELTCKLVKLF 204
Cdd:cd14992    7 LVVIILVSVVGNFIVIAALARHKNLR-------GATNYFIASLAISDLLMALFCTPFNFTYVVSLSWEYGHFLCKIVNYL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 205 QMFSLYLSTYVLVLIGVDRWIAVKYPMK--SLNMAKRCHRLLGGTYILSLVLSLPQFFIFHVARGPFV--EEFYQCVTHG 280
Cdd:cd14992   80 RTVSVYASSLTLTAIAFDRYFAIIHPLKprHRQSYTTTVIIIITIWVVSLLLAIPQLYYATTEVLFSVknQEKIFCCQIP 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 281 FYTADWQEQMYATFTLVFTFLLPLCILFGTYMSTFRTIsssekmfqgsklaNYSTAKLPTQTNRQRLIHKAKMKSLRISV 360
Cdd:cd14992  160 PVDNKTYEKVYFLLIFVVIFVLPLIVMTLAYARISREL-------------WFRKVPGFSIKEVERKRLKCKRRVIKMLV 226
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 442631927 361 VIIIAFLICWTPYYVMMIMFMFlNPDKRLGDDLQDAIFF---FGMSNSLVNPLIY 412
Cdd:cd14992  227 CVVVLFVICWLPFHLFFLLRDF-FPLIMKEKHTLQVYYFlhwIAMSNSMYNPIIY 280
7tmA_capaR cd15134
neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of ...
133-412 1.04e-19

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; CapaR is a G-protein coupled receptor for the Drosophila melanogaster capa neuropeptides (Drm-capa-1 and -2), which act on the Malpighian tubules to increase fluid transport. The capa peptides are evolutionarily related to vertebrate Neuromedin U neuropeptide and contain a C-terminal FPRXamide motif. CapaR regulates fluid homeostasis through its ligands, thereby acts as a desiccation stress-responsive receptor. CapaR undergoes desensitization, with internalization mediated by beta-arrestin-2.


Pssm-ID: 320262 [Multi-domain]  Cd Length: 298  Bit Score: 90.08  E-value: 1.04e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 133 LLGNLLTIwniykTRISRRNSRHTWSAIYslMFHLSIADVLVTWFCIIGEAawcYTV----QWLANELTCKLVKLFQMFS 208
Cdd:cd15134   15 VVGNLCTC-----IVIARNRSMHTATNYY--LFSLAVSDLLLLILGLPFEL---YTIwqqyPWVFGEVFCKLRAFLSEMS 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 209 LYLSTYVLVLIGVDRWIAVKYPMKSLNMAK--RCHRLLGGTYILSLVLSLPQFFIFHV-------ARGPFVEEFYQCVTH 279
Cdd:cd15134   85 SYASVLTITAFSVERYLAICHPLRSHTMSKlsRAIRIIIAIWIIAFVCALPFAIQTRIvyleyppTSGEALEESAFCAML 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 280 gfYTADWQEQMYATFTLVFtFLLPLCILFGTYMSTFRTISSSEKMFQGSKlanySTAKLPTQTNRQRLIhkakmksLRIS 359
Cdd:cd15134  165 --NEIPPITPVFQLSTFLF-FIIPMIAIIVLYVLIGLQLRRSTLLRRGQR----SVSGGRRSSQSRRTV-------LRML 230
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 442631927 360 VVIIIAFLICWTPYYVMMIMFMFLNPDKRLGDDLQDAIF----FFGMSNSLVNPLIY 412
Cdd:cd15134  231 VAVVVAFFICWAPFHAQRLLTVYAKNMTPPYLFINRILFyisgVLYYVSSTVNPILY 287
7tmA_SKR_NK2R cd16004
substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
126-412 2.87e-19

substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The substance-K receptor (SKR), also known as tachykinin receptor 2 (TACR2) or neurokinin A receptor or NK2R, is a G-protein coupled receptor that specifically binds to neurokinin A. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320670 [Multi-domain]  Cd Length: 285  Bit Score: 88.36  E-value: 2.87e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 126 AVMALFSLLGNLLTIWNIYKTRISRrnsrhtwSAIYSLMFHLSIADVLVTWFCIIGEAAWCYTVQWLANELTCKLVKLFQ 205
Cdd:cd16004    8 SLIVLVAVTGNATVIWIILAHRRMR-------TVTNYFIVNLALADLSMAAFNTAFNFVYASHNDWYFGLEFCRFQNFFP 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 206 MFSLYLSTYVLVLIGVDRWIAVKYPMKSLNMAKRCHRLLGGTYILSLVLSLPQFFIFHVargpfveEFYQCVThgFYTAD 285
Cdd:cd16004   81 ITAMFVSIYSMTAIAADRYMAIIHPFKPRLSAGSTKVVIAGIWLVALALAFPQCFYSTV-------TMDQGRT--KCIVA 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 286 WQEQ-------MYATFTLVFTFLLPLCILFGTYMSTFRTISSSEkmfqgsklanystakLPTQTNRQRLIH--KAKMKSL 356
Cdd:cd16004  152 WPGDsggkhqlTYHLAVIVLIYLLPLAVMFVTYSIIGITLWRSA---------------VPGHQAHGAYHRqlQAKKKFV 216
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 442631927 357 RISVVIIIAFLICWTPYYVMMIMFMFlNPDKRLGDDLQD---AIFFFGMSNSLVNPLIY 412
Cdd:cd16004  217 KTMVVVVVTFAICWLPYHLYFILGSF-NEDIYCQKYIQQvylAIFWLAMSSTMYNPIIY 274
7tmA_Galanin_R-like cd14971
galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...
124-412 4.18e-19

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320102 [Multi-domain]  Cd Length: 281  Bit Score: 87.91  E-value: 4.18e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 124 VLAVMALFSLLGNLLTIWNIYKTRISRrnsrhtwSAIYSLMFHLSIADVLVTWFCIIGEAAWCYTVQWLANELTCKLVKL 203
Cdd:cd14971    6 FFALIFLLGLVGNSLVILVVARNKPMR-------STTNLFILNLAVADLTFLLFCVPFTATIYPLPGWVFGDFMCKFVHY 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 204 FQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLNMAKRCHRLL--GGTYILSLVLSLPqFFIFHVARGPFVEEfyQCVTHGF 281
Cdd:cd14971   79 FQQVSMHASIFTLVAMSLDRFLAVVYPLRSLHIRTPRNALAasGCIWVVSLAVAAP-VLALHRLRNYTPGN--RTVCSEA 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 282 YTADWQEQMYATFTLVFTFLLPLCILFGTYMSTFRTISSSEKMFQGSKLANystaklptqtnrqrlihKAKMKSLRISVV 361
Cdd:cd14971  156 WPSRAHRRAFALCTFLFGYLLPLLLICVCYAAMLRHLWRVAVRPVLSEGSR-----------------RAKRKVTRLVLV 218
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 442631927 362 IIIAFLICWTPYYVmMIMFMFLNPDKRLGDDLQDAIFFFGMS--NSLVNPLIY 412
Cdd:cd14971  219 VVVLFAACWGPIHA-ILLLVALGPFPLTYATYALRIWAHCLAysNSAVNPVLY 270
7tmA_EDG-like cd14972
endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...
122-417 4.55e-19

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 341317 [Multi-domain]  Cd Length: 275  Bit Score: 87.73  E-value: 4.55e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 122 VYVLAVMALFSLLGNLLTIWNIYKTRISRRnsrhtwsAIYSLMFHLSIADVLVTWFCIIGeaawCYTVQWLANELT---C 198
Cdd:cd14972    2 LVVAIVLGVFIVVENSLVLAAIIKNRRLHK-------PMYILIANLAAADLLAGIAFVFT----FLSVLLVSLTPSpatW 70
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 199 KLVKLFQMFSLYLSTYVLVLIGVDRWIAVKYPMK-SLNMA-KRCHRLLGGTYILSLVLSLpqffIFHVARGPFVEEFYQC 276
Cdd:cd14972   71 LLRKGSLVLSLLASAYSLLAIAVDRYISIVHGLTyVNNVTnKRVKVLIALVWVWSVLLAL----LPVLGWNCVLCDQESC 146
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 277 VTHGFYTAdwqeQMYATFTLVFtFLLPLCILFGTYMSTFRTISSSekmfqgsklanysTAKLPTQTNRQRLIHKAKMKSL 356
Cdd:cd14972  147 SPLGPGLP----KSYLVLILVF-FFIALVIIVFLYVRIFWCLWRH-------------ANAIAARQEAAVPAQPSTSRKL 208
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 442631927 357 RISVVII-IAFLICWTPYYVMMIMfMFLNPDKRLGDDLQDAIFFFGMSNSLVNPLIYgAFHL 417
Cdd:cd14972  209 AKTVVIVlGVFLVCWLPLLILLVL-DVLCPSVCDIQAVFYYFLVLALLNSAINPIIY-AFRL 268
7tmA_5-HT1_5_7 cd15064
serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...
124-415 9.61e-19

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320192 [Multi-domain]  Cd Length: 258  Bit Score: 86.23  E-value: 9.61e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 124 VLAVMALFSLLGNLLTIWNIYKTRISRRNSRHtwsaiysLMFHLSIADVLVTwfCIIGEAAWCYTVQ--WLANELTCKLV 201
Cdd:cd15064    6 LLSLIILATILGNALVIAAILLTRKLHTPANY-------LIASLAVADLLVA--VLVMPLSAVYELTgrWILGQVLCDIW 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 202 KLFQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLN--MAKRCHRLLGGTYILSLVLSLPQFFIFhvaRGPFVEEFYQCVTH 279
Cdd:cd15064   77 ISLDVTCCTASILHLCVIALDRYWAITDAVEYAHkrTPKRAAVMIALVWTLSICISLPPLFGW---RTPDSEDPSECLIS 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 280 gfytadwQEQMYATFTLVFTFLLPLCILFGTYMSTFRTisssekmfqgsklanystaklptqTNRQRlihkakmKSLRIS 359
Cdd:cd15064  154 -------QDIGYTIFSTFGAFYIPLLLMLILYWKIYRA------------------------AARER-------KAAKTL 195
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 442631927 360 VVIIIAFLICWTPYYVMMIMfMFLNPDKRLGDDLQDAIFFFGMSNSLVNPLIYGAF 415
Cdd:cd15064  196 GIILGAFIVCWLPFFLVALI-VPLCSHCWIPLALKSFFLWLGYFNSLINPLIYTFF 250
7tmA_NKR_NK3R cd16003
neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
126-412 2.11e-18

neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin-K receptor (NKR), also known as tachykinin receptor 3 (TACR3) or neurokinin B receptor or NK3R, is a G-protein coupled receptor that specifically binds to neurokinin B. The tachykinins (TKs) act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320669 [Multi-domain]  Cd Length: 282  Bit Score: 85.75  E-value: 2.11e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 126 AVMALFSLLGNLLTIWNIYKTRISRRNSRHtwsaiysLMFHLSIADVLVTWFCIIGEAAWCYTVQWLANELTCKLVKLFQ 205
Cdd:cd16003    8 GFVVAVAVFGNLIVIWIILAHKRMRTVTNY-------FLVNLAFSDASMAAFNTLINFIYALHSEWYFGEAYCRFHNFFP 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 206 MFSLYLSTYVLVLIGVDRWIAVKYPMKSLNMAKRCHRLLGGTYILSLVLSLPQ--FFIFHVARGPFVeefyqCVTHGFYT 283
Cdd:cd16003   81 ITSVFASIYSMTAIAVDRYMAIIDPLKPRLSATATKVVIGSIWILAFLLAFPQclYSKTKVMPGRTL-----CFVAWPGG 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 284 ADwQEQMYATFTLVFTFLLPLCILFGTYMSTFRTIsssekmfQGSKLANYSTAKLPTQTnrqrlihKAKMKSLRISVVII 363
Cdd:cd16003  156 PD-QHFTYHIIVIVLVYCLPLLVMGITYTIVGITL-------WGGEIPGDTSDKYHEQL-------RAKRKVVKMMIIVV 220
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 442631927 364 IAFLICWTPYYVMMI---MFMFLNPDKRLgDDLQDAIFFFGMSNSLVNPLIY 412
Cdd:cd16003  221 LTFAICWLPYHIYFIvtgLYQQLNRWKYI-QQVYLASFWLAMSSTMYNPIIY 271
7tmA_Proton-sensing_R cd15160
proton-sensing G protein-coupled receptors, member of the class A family of ...
122-412 1.83e-17

proton-sensing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Proton/pH-sensing G-protein coupled receptors sense pH of 7.6 to 6.0. They mediate a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. The proton/pH-sensing receptor family includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4).


Pssm-ID: 320288 [Multi-domain]  Cd Length: 280  Bit Score: 83.20  E-value: 1.83e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 122 VYVLAVMalFSLLGNLLTIWNIYKtRISRRNSRhtwsAIYslMFHLSIADVLVTW---FCIIgeaawcYTVQ---WLANE 195
Cdd:cd15160    6 VYSFVFV--VGLPANCLALWVLYL-QIKKENVL----GVY--LLNLSLSDLLYILtlpLWID------YTANhhnWTFGP 70
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 196 LTCKLVKLFQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLNMAKRCHRLLGGTYILSLVLSLPQFFIFHVARGPFVEEFYQ 275
Cdd:cd15160   71 LSCKVVGFFFYTNIYASIGFLCCIAVDRYLAVVHPLRFRGLRTRRFALKVSASIWVLELGTHSVFLGHDELFRDEPNHTL 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 276 CVTHgfYTAD-WQEQM-YATFTLVftFLLPLCILFGTYMSTFRTISSSekmfqgsklanystaklpTQTNRQRlihKAKM 353
Cdd:cd15160  151 CYEK--YPMEgWQASYnYARFLVG--FLIPLSLILFFYRRVLRAVRQS------------------PSLEREE---KRKI 205
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 442631927 354 KSLRISVVIIiaFLICWTPYYVMM----IMFMFLNPDKRLGDDLQDA-IFFFGMS--NSLVNPLIY 412
Cdd:cd15160  206 IGLLLSIVVI--FLLCFLPYHVVLlvrsVIELVQNGLCGFEKRVFTAyQISLCLTslNCVADPILY 269
7tmA_Angiotensin_R-like cd14985
angiotesin receptor family and its related G protein-coupled receptors, member of the class A ...
130-415 3.63e-17

angiotesin receptor family and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the angiotensin receptors, the bradykinin receptors, apelin receptor as well as putative G-protein coupled receptors (GPR15 and GPR25). Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2 receptor, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Bradykinins (BK) are pro-inflammatory peptides that mediate various vascular and pain responses to tissue injury through its B1 and B2 receptors. Apelin (APJ) receptor binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body, and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake. Orphan receptors, GPR15 and GPR25, share strong sequence homology to the angiotensin II type AT1 and AT2 receptors.


Pssm-ID: 341320 [Multi-domain]  Cd Length: 284  Bit Score: 82.43  E-value: 3.63e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 130 LFSLLGNLLTIWNIYKTRISRRNSrhtwsAIYslMFHLSIAD-VLVTWFCIIGEAAWcYTVQWLANELTCKLVKLFQMFS 208
Cdd:cd14985   12 LVGLLGNLFVVWVFLFPRGPKRVA-----DIF--IANLAAADlVFVLTLPLWATYTA-NQYDWPFGAFLCKVSSYVISVN 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 209 LYLSTYVLVLIGVDRWIAVKYPMKSlnmAKRCHRLLG-----GTYILSLVLSLPQFfifhVARGPFVEEFYQCVTHGFYT 283
Cdd:cd14985   84 MFASIFLLTCMSVDRYLAIVHPVAS---RRLRRRRQArvtcaLIWVVACLLSLPTF----LLRSLQAIENLNKTACIMLY 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 284 ADWQ-EQMYATFTLVFTFLLPLCILFGTYMSTFRTISssekmfqgsklanysTAKLPTQTNRqrlihKAKMKSLRISVVI 362
Cdd:cd14985  157 PHEAwHFGLSLELNILGFVLPLLIILTCYFHIARSLR---------------KRYERTGKNG-----RKRRKSLKIIFAL 216
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 363 IIAFLICWTPYYVMMIMFMFLNPDKRLGDDLQDAI-------FFFGMSNSLVNPLIYGAF 415
Cdd:cd14985  217 VVAFLVCWLPFHFFKFLDFLAQLGAIRPCFWELFLdlglpiaTCLAFTNSCLNPFIYVFV 276
7tmA_C5aR cd15114
complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of ...
123-412 6.33e-17

complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320242 [Multi-domain]  Cd Length: 274  Bit Score: 81.30  E-value: 6.33e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 123 YVLAVMALFSLLGNLLTIWniyktrISRRNSRHTWSAIYSLmfHLSIADVL------VTWFCIIGEAAWCYtvqwlaNEL 196
Cdd:cd15114    5 VLYAVVFLVGVPGNALVAW------VTGFEAKRSVNAVWFL--NLAVADLLcclslpILAVPIAQDGHWPF------GAA 70
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 197 TCKLVKLFQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLNMAKRC--HRLLGGTYILSLVLSLPQfFIFHVARGPFVEEFY 274
Cdd:cd15114   71 ACKLLPSLILLNMYASVLLLTAISADRCLLVLRPVWCQNHRRARlaWIACGAAWLLALLLTVPS-FIYRRIHQEHFPEKT 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 275 QCVTHgfYTADWQ-EQMYATFTLVFTFLLPLCILFGTYMSTFRTISSSekmfqgsklanystaklptQTNRQRlihkakm 353
Cdd:cd15114  150 VCVVD--YGGSTGvEWAVAIIRFLLGFLGPLVVIASCHGVLLVRTWSR-------------------RRQKSR------- 201
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 442631927 354 KSLRISVVIIIAFLICWTPYYVMMIMFMFLNPDKRL---GDDLQDAIFFFGMSNSLVNPLIY 412
Cdd:cd15114  202 RTLKVVTAVVVGFFLCWTPYHVVGLIIAASAPNSRLlanALKADPLTVSLAYINSCLNPIIY 263
7tmA_Gal2_Gal3_R cd15097
galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G ...
125-412 7.77e-17

galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320225 [Multi-domain]  Cd Length: 279  Bit Score: 81.03  E-value: 7.77e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 125 LAVMALFSLLGNLLTIWNIYKTRISRRNSRHTWSAIYSLMFHLSIADVLVTWFCIIGEAAwCYTVQ-WLANELTCKLVKL 203
Cdd:cd15097    1 VIVPVVFSLIFLLGTVGNSLVLAVLLRSGQSGHNTTNLFILNLSVADLCFILFCVPFQAT-IYSLEgWVFGSFLCKAVHF 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 204 FQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLNMAKRCHRL--LGGTYILSLVLSLPQFFIFHVARgpfVEEFYQCVTHgf 281
Cdd:cd15097   80 FIYLTMYASSFTLAAVSVDRYLAIRYPLRSRELRTPRNAVaaIALIWGLSLLFAGPYLSYYDLID---YANSTVCMPG-- 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 282 yTADWQEQMYATFTLVFTFLLPLCILFGTYMSTFRTISSSEkmfqgSKLANYSTAKlptqtnrqrlihKAKMKSLRISVV 361
Cdd:cd15097  155 -WEEARRKAMDTCTFAFGYLIPVLVVSLSYTRTIKYLWTAV-----DPLEAMSESK------------RAKRKVTKMIII 216
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 442631927 362 IIIAFLICWTPYYVMMIMFMFLN-PDKRLGDDLQDAIFFFGMSNSLVNPLIY 412
Cdd:cd15097  217 VTALFCLCWLPHHVVILCYLYGDfPFNQATYAFRLLSHCMAYANSCLNPIVY 268
7tmA_KiSS1R cd15095
KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of ...
124-415 9.03e-17

KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled KiSS1-derived peptide receptor (GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (previously known as metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. The KiSS1 receptor is coupled to G proteins of the G(q/11) family, which lead to activation of phospholipase C and increase of intracellular calcium. This signaling cascade plays an important role in reproduction by regulating the secretion of gonadotropin-releasing hormone.


Pssm-ID: 320223 [Multi-domain]  Cd Length: 288  Bit Score: 81.17  E-value: 9.03e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 124 VLAVMALFSLLGNLLTIWNIYKtrisrrnSRHTWSAIYSLMFHLSIADVLVTWFCIIGEAAWCYTVQWLANELTCKLVKL 203
Cdd:cd15095    6 IFAIIFLVGLAGNSLVIYVVSR-------HREMRTVTNYYIVNLAVTDLAFLVCCVPFTAALYATPSWVFGDFMCKFVNY 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 204 FQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLNmakrcHR-------LLGGTYILSLVLSLPQFFIFHVARGPFVEEFYQC 276
Cdd:cd15095   79 MMQVTVQATCLTLTALSVDRYYAIVHPIRSLR-----FRtprvavvVSACIWIVSFLLSIPVAIYYRLEEGYWYGPQTYC 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 277 vTHGFYTADWQeQMYATFTLVFTFLLPLCILFGTYMSTFRtissseKMFQGSKLANYSTAKLPTQTNRQrlihkaKMKSL 356
Cdd:cd15095  154 -REVWPSKAFQ-KAYMIYTVLLTYVIPLAIIAVCYGLILR------RLWRRSVDGNNQSEQLSERALRQ------KRKVT 219
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 442631927 357 RISVVIIIAFLICWTPYYVMMIMFMFlNPDKrlgdDLQDAIFFFGM-------SNSLVNPLIYGAF 415
Cdd:cd15095  220 RMVIVVVVLFAICWLPNHVLNLWQRF-DPNF----PETYATYALKIaalclsyANSAVNPFVYAFM 280
7tmA_CCK_R cd15206
cholecystokinin receptors, member of the class A family of seven-transmembrane G ...
126-412 1.46e-16

cholecystokinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320334 [Multi-domain]  Cd Length: 269  Bit Score: 80.13  E-value: 1.46e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 126 AVMALFSLLGNLLTIwniyKTRISRRNSRhTWSAIYSLmfHLSIADVLVTWFC----IIGeaawcytvQWLAN----ELT 197
Cdd:cd15206    8 SVIFLLAVVGNILVI----VTLVQNKRMR-TVTNVFLL--NLAVSDLLLAVFCmpftLVG--------QLLRNfifgEVM 72
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 198 CKLVKLFQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLNMAKRCH--RLLGGTYILSLVLSLPqFFIFHVARGPFVEEFYQ 275
Cdd:cd15206   73 CKLIPYFQAVSVSVSTFTLVAISLERYFAICHPLKSRVWQTLSHayKVIAGIWLLSFLIMSP-ILVFSNLIPMSRPGGHK 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 276 CVThgFYTADWQEQMYATFTLVFTFLLPLCILFGTYMSTFRTISssekmfqgsklanystaklptqtnrqrlihKAKMKS 355
Cdd:cd15206  152 CRE--VWPNEIAEQAWYVFLDLMLLVIPGLVMSVAYGLISWTLL------------------------------EAKKRV 199
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 442631927 356 LRISVVIIIAFLICWTPYYVMMIMFMFLNPD--KRLGDDLQDAIFFFGMSNSLVNPLIY 412
Cdd:cd15206  200 IRMLFVIVVEFFICWTPLYVINTWKAFDPPSaaRYVSSTTISLIQLLAYISSCVNPITY 258
7tmA_Opsin5_neuropsin cd15074
neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...
125-412 1.53e-16

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.


Pssm-ID: 320202 [Multi-domain]  Cd Length: 284  Bit Score: 80.40  E-value: 1.53e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 125 LAVMALFSLLGNLLTIWNIYKTRISRRnsrhtwsAIYSLMFHLSIADVLVTWFCIIGEAAWCYTVQWLANELTCKLVKLF 204
Cdd:cd15074    7 LTVIGILSTLGNGTVLFVLYRRRSKLK-------PAELLTVNLAVSDLGISVFGYPLAIISAFAHRWLFGDIGCVFYGFC 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 205 QMFSLYLSTYVLVLIGVDRWIAVKYPMK-SLNMAKRCHRLLGGTYILSLVLSLPQFFifHVARgpFVEEFYqcvtHGFYT 283
Cdd:cd15074   80 GFLFGCCSINTLTAISIYRYLKICHPPYgPKLSRRHVCIVIVAIWLYALFWAVAPLV--GWGS--YGPEPF----GTSCS 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 284 ADW-------QEQMYATFTLVFTFLLPLCILFGTYMSTFRTISSSEKMFQGsklanystaklptQTNRQRLIHKAKMKSL 356
Cdd:cd15074  152 IDWtgasasvGGMSYIISIFIFCYLLPVLIIVFSYVKIIRKVKSSRKRVAG-------------FDSRSKRQHKIERKVT 218
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 357 RISVVIIIAFLICWTPYYVMMIMFMFLNPDKrlgddLQDAIF----FFGMSNSLVNPLIY 412
Cdd:cd15074  219 KVAVLICAGFLIAWTPYAVVSMWSAFGSPDS-----VPILASilpaLFAKSSCMYNPIIY 273
7tmA_GPR83 cd15389
G protein-coupled receptor 83, member of the class A family of seven-transmembrane G ...
126-412 1.75e-16

G protein-coupled receptor 83, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR83, also known as GPR72, is widely expressed in the brain, including hypothalamic nuclei which is involved in regulating energy balance and food intake. The hypothalamic expression of GPR83 is tightly regulated in response to nutrient availability and is decreased in obese mice. A recent study suggests that GPR83 has a critical role in the regulation of systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms. GPR83 shares a significant amino acid sequence identity with the tachykinin receptors, however its endogenous ligand is unknown.


Pssm-ID: 320511 [Multi-domain]  Cd Length: 285  Bit Score: 80.07  E-value: 1.75e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 126 AVMALFSLLGNLLTIWNIYKTRISRrnsrhtwSAIYSLMFHLSIADVLVTWFCIIGEAAWCYTVQWLANELTCKLVKLFQ 205
Cdd:cd15389    8 SIIIVISLFGNSLVCHVIFKNKRMH-------TATNLFIVNLAVSDILITLLNTPFTLVRFVNSTWVFGKIMCHLSRFAQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 206 MFSLYLSTYVLVLIGVDRWIAVKYPMKSLNMAKRCHRLLGGTYILSLVLSLPQFFIFHVARGPFVEE--FYQCVTHGFYT 283
Cdd:cd15389   81 YCSVYVSTLTLTAIALDRHRVILHPLKPRITPCQGVVVIAIIWIMASCLSLPHAIYQKLVEFEYSNErtRSRCLPSFPEP 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 284 AD--WQEQMYATFTLVftFLLPLCILFGTYMSTFRTIsssekmfqgsklanYSTAKLPTQTNRQRLIH-KAKMKSLRISV 360
Cdd:cd15389  161 SDlfWKYLDLATFILQ--YVLPLLIIGVAYTRVAKKL--------------WLRNAIGDVTTEQYVAQrRKKKKTIKMLM 224
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 442631927 361 VIIIAFLICWTP--YYVMMIMFMFLNPDkrlgddlqDAIFF----FGMSNSLVNPLIY 412
Cdd:cd15389  225 LVVLLFAICWLPlnCYHVLLSSHPIRSN--------SALFFafhwLAMSSTCYNPFIY 274
7tmA_LTB4R cd14975
leukotriene B4 receptors, member of the class A family of seven-transmembrane G ...
119-375 2.14e-16

leukotriene B4 receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the G(q)-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320106 [Multi-domain]  Cd Length: 278  Bit Score: 79.83  E-value: 2.14e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 119 LLKVYVLAVMALFSLLGNLLTIWNIYKTRisrRNSRHTwsaiYSLMFHLSIADVLVtwfcIIGEAAWCY---TVQWLANE 195
Cdd:cd14975    1 VLGCTLLSLAFAIGLPGNSFVIWSILIKV---KQRSVT----MLLVLNLALADLAV----LLTLPVWIYflaTGTWDFGL 69
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 196 LTCKLVKLFQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLNMAKR--CHRLLGGTYILSLVLSLPQFFIFHVARGPFVEEF 273
Cdd:cd14975   70 AACKGCVYVCAVSMYASVFLITLMSLERFLAVSRPFVSQGWRAKalAHKVLAIIWLLAVLLATPVIAFRHVEETVENGMC 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 274 YQCvthgfYTADWQEQMYATFTLVFTFLLPLCILFGTYMSTFRTIsssekmfqgsklanystaklptqtnrQRLIHKAKM 353
Cdd:cd14975  150 KYR-----HYSDGQLVFHLLLETVVGFAVPFTAVVLCYSCLLRRL--------------------------RRRRFRRRR 198
                        250       260
                 ....*....|....*....|..
gi 442631927 354 KSLRISVVIIIAFLICWTPYYV 375
Cdd:cd14975  199 RTGRLIASVVVAFAACWLPYHV 220
7tmA_TAARs cd15055
trace amine-associated receptors, member of the class A family of seven-transmembrane G ...
122-416 2.27e-16

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320183 [Multi-domain]  Cd Length: 285  Bit Score: 79.91  E-value: 2.27e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 122 VYVLAVMALFSLL---GNLLTIwniykTRISRRNSRHTWSAIysLMFHLSIAD----VLVTWFCIIGEAAWCytvqWLAN 194
Cdd:cd15055    1 VLLYIVLSSISLLtvlGNLLVI-----ISISHFKQLHTPTNL--LLLSLAVADflvgLLVMPFSMIRSIETC----WYFG 69
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 195 ELTCKLVKLFQMFSLYLSTYVLVLIGVDRWIAV----KYPMK-SLNMAKRChrlLGGTYILSLVLSLPQFFIFHVARGPF 269
Cdd:cd15055   70 DTFCKLHSSLDYILTSASIFNLVLIAIDRYVAVcdplLYPTKiTIRRVKIC---ICLCWFVSALYSSVLLYDNLNQPGLI 146
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 270 VEE--FYQCVThgFYTADWqeqmyATFTLVFTFLLPLCILFGTYMSTF-------RTISSsekmfqgsklanystakLPT 340
Cdd:cd15055  147 RYNscYGECVV--VVNFIW-----GVVDLVLTFILPCTVMIVLYMRIFvvarsqaRAIRS-----------------HTA 202
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 341 QTNRQRLIHKAKMKSLRISV----VIIIAFLICWTPYYVMMIMFMFLNPDkrlgDDLQDAIFFFGMSNSLVNPLIYGAFH 416
Cdd:cd15055  203 QVSLEGSSKKVSKKSERKAAktlgIVVGVFLLCWLPYYIVSLVDPYISTP----SSVFDVLIWLGYFNSCLNPLIYALFY 278
7tmA_D2-like_dopamine_R cd15053
D2-like dopamine receptors, member of the class A family of seven-transmembrane G ...
125-415 2.45e-16

D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320181 [Multi-domain]  Cd Length: 263  Bit Score: 79.31  E-value: 2.45e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 125 LAVMALFSLLGNLLTIWNIYKTRisrrnSRHTwsAIYSLMFHLSIADVLVTwfCIIGEAAWCYTVQWLANELTCKLVKLF 204
Cdd:cd15053    7 LLLLPLLTVFGNVLVIMSVFRER-----SLQT--ATNYFIVSLAVADLLVA--ILVMPFAVYVEVNGGKWYLGPILCDIY 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 205 QMFSLYLST---YVLVLIGVDRWIAVKYPMKsLNMAKRCHR---LLGGTYILSLVLSLPQFFIFHVARGpfvEEFYQCVt 278
Cdd:cd15053   78 IAMDVMCSTasiFNLCAISIDRYIAVTQPIK-YARQKNSKRvllTIAIVWVVSAAIACPLLFGLNNVPY---RDPEECR- 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 279 hgFYTADwqeqmYATFTLVFTFLLPLCILFGTYMSTFRTIsssekmfqgsklanystaklptqtnrqRLIHKAkMKSLRI 358
Cdd:cd15053  153 --FYNPD-----FIIYSSISSFYIPCIVMLLLYYRIFRAL---------------------------RREKKA-TKTLAI 197
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 442631927 359 svvIIIAFLICWTPYYVMMIMFM----FLNPDKRLGDDLQDAIFFFGMSNSLVNPLIYGAF 415
Cdd:cd15053  198 ---VLGVFLFCWLPFFTLNILNAicpkLQNQSCHVGPALFSLTTWLGYVNSFLNPIIYTIF 255
7tmA_ETH-R cd14997
ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...
119-412 2.56e-16

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320128 [Multi-domain]  Cd Length: 294  Bit Score: 80.03  E-value: 2.56e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 119 LLKVYVLAVMALFSLLGNLLTIWNIYKTRISRrnsrhtwSAIYSLMFHLSIADVLVTWFCIIGEAAWCYTVQ-WLANELT 197
Cdd:cd14997    1 VLVSVVYGVIFVVGVLGNVLVGIVVWKNKDMR-------TPTNIFLVNLSVADLLVLLVCMPVALVETWAREpWLLGEFM 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 198 CKLVKLFQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLNM--AKRCHRLLGGTYILSLVLSLPQFFIFHVARGPFV--EEF 273
Cdd:cd14997   74 CKLVPFVELTVAHASVLTILAISFERYYAICHPLQAKYVctKRRALVIIALIWLLALLTSSPVLFITEFKEEDFNdgTPV 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 274 YQCVTHgfytADWQEQM-YATFTLVFTFLLPLCILFGTYMSTFRtisssekmfqgsKLANYSTAKLPTQTNRQRLIHKAK 352
Cdd:cd14997  154 AVCRTP----ADTFWKVaYILSTIVVFFVVPLAILSGLYSVICR------------RLVGHPALESRRADAANRHTLRSR 217
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 442631927 353 MKSLRISVVIIIAFLICWTPYYVMMIMFMFLNPDKRLGDDLQDAIFFFGMS------NSLVNPLIY 412
Cdd:cd14997  218 RQVVYMLITVVVLFFVCLLPFRVVTLWIIFAPDEDLQALGLEGYLNLLVFCrvmvylNSALNPILY 283
7tmA_alpha1A_AR cd15325
alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
124-412 2.80e-16

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320448 [Multi-domain]  Cd Length: 261  Bit Score: 79.17  E-value: 2.80e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 124 VLAVMALFSLLGNLLTIwniyktrISRRNSRHTWSAIYSLMFHLSIADVLVTWFCIIGEAAWCYTVQWLANELTCKLVKL 203
Cdd:cd15325    6 ILGGFILFGVLGNILVI-------LSVACHRHLQTVTHYFIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAA 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 204 FQMFSLYLSTYVLVLIGVDRWIAVKYPMK--SLNMAKRCHRLLGGTYILSLVLSLPQFFIFhvaRGPFVEEFYQCVTHgf 281
Cdd:cd15325   79 VDVLCCTASIMSLCIISIDRYIGVSYPLRypSIMTERRGLLALLCVWVLSLVISIGPLFGW---KEPAPEDETICQIT-- 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 282 ytadwQEQMYATFTLVFTFLLPLCILFGTYmstFRTISSSEKMFQGSKLAnystaklptqtnrqrlihkakmKSLRIsvv 361
Cdd:cd15325  154 -----EEPGYALFSALGSFYLPLAIILVMY---CRVYVVALKFSREKKAA----------------------KTLGI--- 200
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 442631927 362 IIIAFLICWTPYYVMMIMFMFLnPDKRLGDDLQDAIFFFGMSNSLVNPLIY 412
Cdd:cd15325  201 VVGCFVLCWLPFFLVMPIGSIF-PAYKPSDTVFKITFWLGYFNSCINPIIY 250
7tmA_Opsin_Gq_invertebrates cd15337
invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled ...
119-382 3.22e-16

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The invertebrate Gq-coupled opsin subfamily includes the arthropod and mollusc visual opsins. Like the vertebrate visual opsins, arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. The invertebrate Gq opsins are closely related to the vertebrate melanopsins, the primary photoreceptor molecules for non-visual responses to light, and the R1-R6 photoreceptors, which are the fly equivalent to the vertebrate rods. The Gq opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320459 [Multi-domain]  Cd Length: 292  Bit Score: 79.67  E-value: 3.22e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 119 LLKVYVlAVMALFSLLGNLLTIWNIYKTRISRRNSRhtwsaiySLMFHLSIADV---LVTWFCIIGEAawCYTVQWLANE 195
Cdd:cd15337    2 LIGIYI-AIVGILGVIGNLLVIYLFSKTKSLRTPSN-------MFIINLAISDFgfsAVNGFPLKTIS--SFNKKWIWGK 71
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 196 LTCKLVKLFQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLNMA--KRCHRLLGGTYILSLVLSLPQFFIFhvarGPFVEEF 273
Cdd:cd15337   72 VACELYGFAGGIFGFMSITTLAAISIDRYLVIAKPLEAMKKMtfKRAFIMIIIIWLWSLLWSIPPFFGW----GRYVPEG 147
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 274 YQC-VTHGFYTADWQEQMYATFTLVFTFLLPLCILFGTYMSTFRTISSSEKMFQgsklanySTAK--LPTQTNRQRLIHK 350
Cdd:cd15337  148 FQTsCTFDYLSRDLNNRLFILGLFIFGFLCPLLIIIFCYVNIIRAVRNHEKEMT-------QTAKsgMGKDTEKNDARKK 220
                        250       260       270
                 ....*....|....*....|....*....|..
gi 442631927 351 AKMKSLRISVVIIIAFLICWTPYYVMMIMFMF 382
Cdd:cd15337  221 AEIRIAKVAIILISLFLLSWTPYAVVALLGQF 252
7tmA_LTB4R2 cd15122
leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of ...
125-412 1.71e-15

leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320250 [Multi-domain]  Cd Length: 281  Bit Score: 77.15  E-value: 1.71e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 125 LAVMALFSLLGNLLTIWNIYKTRISRRNSrhtwsAIYSLMFHLSIAD---VLVTWFCIigeaAWCYTVQWLANELTCKLV 201
Cdd:cd15122    7 LLLAALLGLPGNGFIIWSILWKMKARGRS-----VTCILILNLAVADgavLLLTPFFI----TFLTRKTWPFGQAVCKAV 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 202 KLFQMFSLYLSTYVLVLIGVDRWIAVKYPM--KSLNMAKRCHRLLGGTYILSLVLSLPQFFIFHVARGpfvEEFYQCVTH 279
Cdd:cd15122   78 YYLCCLSMYASIFIIGLMSLDRCLAVTRPYlaQSLRKKALVRKILLAIWLLALLLALPAFVYRHVWKD---EGMNDRICE 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 280 GFYTADWQEQMYATFTLVFTFLLPLCILFGTYMSTFRTISSSekmfqgsklanystaklptqtnrqRLIHKAKMKslRIS 359
Cdd:cd15122  155 PCHASRGHAIFHYTFETLVAFVLPFGVILFSYSVILVRLKGA------------------------RFRRRARVE--KLI 208
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 442631927 360 VVIIIAFLICWTPYYVMMIMFMFLN-PDKRLGDDLQD----------AIFFFgmsNSLVNPLIY 412
Cdd:cd15122  209 AAIVVAFALLWVPYHVVNLLQVVANlAPGEVLEKLGGaakaaragatALAFF---SSSVNPLLY 269
7tmA_NPY6R cd15396
neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G ...
119-413 1.72e-15

neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320518 [Multi-domain]  Cd Length: 293  Bit Score: 77.57  E-value: 1.72e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 119 LLKVYVLAVMALFSLLGNLLTIwniykTRISRRNSRHTWSAIysLMFHLSIADVLVTWFCIIGEAAWCYTVQWLANELTC 198
Cdd:cd15396    1 FLLIIAYSVVTIVGLFGNLCLI-----TIIKKQKEEHNVTNI--LIANLSLSDVLVCVMCIPFTAVYTLMDHWIFGETMC 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 199 KLVKLFQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLNMAKRCHRLLGGTYILSLVLSLPQFFIFHVARGPFVE-----EF 273
Cdd:cd15396   74 KLTSFVQSVSVSVSIFSLVLIAIERYQLIVNPRGWKPSASHAYWGIVLIWLFSLMISIPFLIFHQLTDEPFRNlsshsDF 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 274 YQ----CVTHgfYTADWQEQMYATFTLVFTFLLPLCILFGTYMSTF----RTISSSEKMfqgsklanystaklptQTNRQ 345
Cdd:cd15396  154 YKdkvvCIEA--WPSETERLIFTTSLLVFQYFVPLGFIFICYLKIFvclkKRNSKIDRM----------------RENES 215
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 442631927 346 RLIHKAKMKSLRISvvIIIAFLICWTPYYVMMIMFMFLNpdKRLGDDLQDAIF----FFGMSNSLVNPLIYG 413
Cdd:cd15396  216 RLSENKRINTMLIS--IVVTFAACWLPLNIFNVVFDWNH--EVLMSCHHNLVFtlchLVAMVSTCINPIFYG 283
7tmA_Glycoprotein_LRR_R-like cd14980
glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, ...
119-412 1.98e-15

glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the glycoprotein hormone receptors (GPHRs), vertebrate receptors containing 17 leucine-rich repeats (LGR4-6), and the relaxin family peptide receptors (also known as LGR7 and LGR8). They are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone receptor family contains receptors for the pituitary hormones, thyrotropin (thyroid-stimulating hormone receptor), follitropin (follicle-stimulating hormone receptor), and lutropin (luteinizing hormone receptor). Glycoprotein hormone receptors couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein. Two orphan GPCRs, LGR7 and LGR8, have been recently identified as receptors for the relaxin peptide hormones.


Pssm-ID: 320111 [Multi-domain]  Cd Length: 286  Bit Score: 77.28  E-value: 1.98e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 119 LLKVYVLaVMALFSLLGNLLTI-WNIYKtrisrRNSRHtwSAIYSLMFHLSIADVLVTWFCII---------GEAAwCYT 188
Cdd:cd14980    2 SLRIFIW-IIGILALIGNILVIiWHISS-----KKKKK--KVPKLLIINLAIADFLMGIYLLIiaiadqyyrGRYA-QYS 72
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 189 VQWLaNELTCKLVKLFQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLNMAKRCHRL-LGGTYILSLVLS-LPQFFIFHVar 266
Cdd:cd14980   73 EEWL-RSPPCLLACFLVSLSSLMSVLMMLLITLDRYICIVYPFSNKRLSYKSAKIiLILGWLFSIIFAaIPILYSINQ-- 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 267 gPFVEEFYQ----C----VTHGFYtadwqeQMYATFTLVFTFL--LPLCILfgtYMSTFRTISSSEKmfqgsklanysta 336
Cdd:cd14980  150 -PGDNRLYGyssiCmpsnVSNPYY------RGWLIAYLLLTFIawIIICIL---YILIFISVRKSRK------------- 206
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 442631927 337 klptqtNRQRLIHKAKMKSLRISVVIIIAFLICWTPYYVMMIMFMfLNPDKRLGDDLQ-DAIFFFGMsNSLVNPLIY 412
Cdd:cd14980  207 ------SARRSSSKRDKRIAIRLALILITDLICWLPYYIVIFSGL-LTSTEIDIHVLQfIAILALPL-NSAINPYLY 275
7tmA_CXCR5 cd15181
CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G ...
124-412 2.42e-15

CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR5 is a B-cell selective receptor that binds specifically to the homeostatic chemokine CXCL13 and regulates adaptive immunity. The receptor is found on all peripheral blood and tonsillar B cells and is involved in lymphocyte migration (homing) to specific tissues and development of normal lymphoid tissue. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341336 [Multi-domain]  Cd Length: 281  Bit Score: 76.71  E-value: 2.42e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 124 VLAVMALFSLLGNLLTIwniyKTRISRRNSRHTwSAIYslMFHLSIADVL--VTWFCIIGEAAwcytVQWLANELTCKLV 201
Cdd:cd15181    6 AYSLVFLLGVVGNGLVL----TILLRRRRSRRT-TENY--LLHLALADLLllLTFPFSVVESI----AGWVFGTFLCKLV 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 202 KLFQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLNMAK--RCHRLLGGTYILSLVLSLPQFFIFHVARGPFVE----EFYQ 275
Cdd:cd15181   75 GAIHKLNFYCSSLLLACISVDRYLAIVHAIHSYRHRRlrSVHLTCGSIWLVCFLLSLPNLVFLEVETSTNANrtscSFHQ 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 276 CVTHGfyTADWQEQMYATFTLVftFLLPLCILFGTYMSTFRTISSSEKMFQgsklanystaklptqtnrqrlihkaKMKS 355
Cdd:cd15181  155 YGIHE--SNWWLTSRFLYHVVG--FFLPLLIMGYCYATIVVTLCQSSRRLQ-------------------------KQKA 205
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 442631927 356 LRISVVIIIAFLICWTPYYVMmimfMFLNPDKRLG---------DDLQDAIF---FFGMSNSLVNPLIY 412
Cdd:cd15181  206 IRVAILVTLVFCLCWLPYNIV----IFLDTLDDLKavvkncklnDLLDAAITvteSLGFSHCCLNPILY 270
7tmA_Anaphylatoxin_R-like cd14974
anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class ...
124-412 7.81e-15

anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes anaphylatoxin receptors, formyl peptide receptors (FPR), prostaglandin D2 receptor 2, GPR1, and related chemokine receptors. The anaphylatoxin receptors are a group of G-protein coupled receptors that bind anaphylatoxins. The members of this group include C3a and C5a receptors. The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed mainly on polymorphonuclear and mononuclear phagocytes and bind N-formyl-methionyl peptides (FMLP), which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Chemokine receptor-like 1 (also known as chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. GPR1 is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1.


Pssm-ID: 320105 [Multi-domain]  Cd Length: 274  Bit Score: 75.03  E-value: 7.81e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 124 VLAVMALFSLLGNLLTIWnIYKTRIsRRNSRHTWsaiyslMFHLSIADVLVTWFCIIGEAAWCYTVQWLANELTCKLVKL 203
Cdd:cd14974    6 LYALIFLLGLPGNGLVIW-VAGFKM-KRTVNTVW------FLNLALADFLFCLFLPFLIVYIAMGHHWPFGSVLCKLNSF 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 204 FQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLN--MAKRCHRLLGGTYILSLVLSLPQFFIFHVARGPF-VEEFYQCVTHg 280
Cdd:cd14974   78 VISLNMFASVFLLTAISLDRCLLVLHPVWAQNhrTVRLASVVCVGIWILALVLSVPYFVFRDTVTHHNgRSCNLTCVED- 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 281 fYTADWQEQMYATFT-LVFTFLLPLCILFGTYmstfrtisssekmfqgsklanystAKLPTQTNRQRLIhkAKMKSLRIS 359
Cdd:cd14974  157 -YDLRRSRHKALTVIrFLCGFLLPLLIIAICY------------------------SVIAVKLRRKRLA--KSSKPLRVL 209
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 442631927 360 VVIIIAFLICWTPYYVmmIMFMFLNPDKRLGDDLQDAIFF---FGMSNSLVNPLIY 412
Cdd:cd14974  210 LAVVVAFFLCWLPYHV--FALLELVAAAGLPEVVLLGLPLatgLAYFNSCLNPILY 263
7tmA_PSP24-like cd15213
G protein-coupled receptor PSP24 and similar proteins, member of the class A family of ...
124-412 9.17e-15

G protein-coupled receptor PSP24 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes two human orphan receptors, GPR45 and GPR65, and their closely related proteins found in vertebrates and invertebrates. GPR45 and GPR 65 are also called PSP24-alpha (or PSP24-1) and PSP24-beta (or PSP24-2) in other vertebrates, respectively. These receptors exhibit the highest sequence homology to each other. PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Instead, sphingosine 1-phosphate and dioleoylphosphatidic acid have been shown to act as low affinity agonists for GPR63. PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320341 [Multi-domain]  Cd Length: 262  Bit Score: 74.71  E-value: 9.17e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 124 VLAVMALFSLLGNLLTIWNIYKTRISRrnsrhtwSAIYSLMFHLSIADVLVTWFCIIGEAAWCYTVQWLANELTCKLVKL 203
Cdd:cd15213    6 LMILMIFVGFLGNSIVCLIVYQKPAMR-------SAINLLLANLAFSDIMLSLVCMPFAAVTIITGRWIFGDIFCRISAM 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 204 FQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLNMAkRCHRLLGGTYILSLVLSLPQffIFHVARGPFVEEFYQCVTHgfYT 283
Cdd:cd15213   79 LYWFFVLEGVAILLIISVDRYLIIVQRQDKLNPH-RAKILIAVSWVLSFCVSFPP--LVGWGKYEFPPRAPQCVLG--YT 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 284 ADWQEQMYATFTLVFTFLLPLCILFGTYMSTFRTISSsekmfqgsklanystaklptqtnrqrlihkAKMKSLRISVVII 363
Cdd:cd15213  154 ESPADRIYVVLLLVAVFFIPFLIMLYSYFCILNTVRS------------------------------FKTRAFTTILILF 203
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 442631927 364 IAFLICWTPYYVMMIMFMFLNPdKRLGDDLQDAIFFFGMSNSLVNPLIY 412
Cdd:cd15213  204 IGFSVCWLPYTVYSLLSVFSRY-SSSFYVISTCLLWLSYLKSAFNPVIY 251
7tmA_FPR-like cd15117
N-formyl peptide receptors, member of the class A family of seven-transmembrane G ...
120-412 1.31e-14

N-formyl peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed at elevated levels on polymorphonuclear and mononuclear phagocytes. FPRs bind N-formyl peptides, which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Activation of FPRs by N-formyl peptides such as N-formyl-Met-Leu-Phe (FMLP) triggers a signaling cascade that stimulates neutrophil accumulation, phagocytosis and superoxide production. These responses are mediated through a pertussis toxin-sensitive G(i) protein that activates a PLC-IP3-calcium signaling pathway. While FPRs are involved in host defense responses to bacterial infection, they can also suppress the immune system under certain conditions. Yet, the physiological role of the FPR family is not fully understood.


Pssm-ID: 320245 [Multi-domain]  Cd Length: 288  Bit Score: 74.77  E-value: 1.31e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 120 LKVYVLAVMALFSLLGNLLTIWniyktrISRRNSRHTWSAIysLMFHLSIADVLVTWFCIIGEAAWCYTVQWLANELTCK 199
Cdd:cd15117    2 LSLVIYSSAFVLGTLGNGLVIW------VTGFRMTRTVTTV--CFLNLAVADFAFCLFLPFSVVYTALGFHWPFGWFLCK 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 200 LVKLFQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLN--MAKRCHRLLGGTYILSLVLSLPqFFIFHVARGPfveefYQCV 277
Cdd:cd15117   74 LYSTLVVFNLFASVFLLTLISLDRCVSVLWPVWARNhrTPARAALVAVGAWLLALALSGP-HLVFRDTRKE-----NGCT 147
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 278 THGFYTADWQE-------------QMYATFTL---VFTFLLPLCILFGTYmstfrtisssekmfqgsklaNYSTAKLptq 341
Cdd:cd15117  148 HCYLNFDPWNEtaedpvlwletvvQRLSAQVItrfVLGFLVPLVIIGGCY--------------------GLIAARL--- 204
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 442631927 342 tNRQRLIHKAkmKSLRISVVIIIAFLICWTPYYVMMIM----FMFLNPDK-RLGDDLQDAIFFFGMSNSLVNPLIY 412
Cdd:cd15117  205 -WREGWVHSS--RPFRVLTAVVAAFFLCWFPFHLVSLLelvvILNQKEDLnPLLILLLPLSSSLACVNSCLNPLLY 277
7tmA_P2Y1-like cd15168
P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of ...
124-412 1.36e-14

P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y1-like receptors as well as other closely related orphan receptors, such as GPR91 (a succinate receptor) and GPR80/GPR99 (an alpha-ketoglutarate receptor).


Pssm-ID: 341329 [Multi-domain]  Cd Length: 284  Bit Score: 74.66  E-value: 1.36e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 124 VLAVMALFSLLGNLLTIWniyktRISRRNSRHTWSAIYslMFHLSIADVLvtWFCIIGEAAWCYTV--QWLANELTCKLV 201
Cdd:cd15168    6 VYGVVFLVGLLLNSVVLY-----RFIFHLKPWNSSAIY--MFNLAVSDLL--YLLSLPFLIYYYANgdHWIFGDFMCKLV 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 202 KLFQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLNMAKRCHRLLGG--TYILSLVLSLPQFFIFHVARgpfVEEFYQC--- 276
Cdd:cd15168   77 RFLFYFNLYGSILFLTCISVHRYLGICHPLRSLGKLKKRHAVAISvaVWILVLLQLLPILFFATTGR---KNNRTTCydt 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 277 VTHGFYTAdwqEQMYATFTLVFTFLLPLCILFGTYMSTFRTIsssekmfqgsklanYSTAKLPTQTNRQRlihkakmKSL 356
Cdd:cd15168  154 TSPEELND---YVIYSMVLTGLGFLLPLLIILACYGLIVRAL--------------IRKLGEGVTSALRR-------KSI 209
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 442631927 357 RISVVIIIAFLICWTPYYVMMIMFMflnpDKRLGDDLQDAIFFFGMS------------NSLVNPLIY 412
Cdd:cd15168  210 RLVIIVLALFAVCFLPFHVTRTINL----AARLLSGTASCATLNGIYvaykvtrplaslNSCLNPLLY 273
7tmA_CMKLR1 cd15116
chemokine-like receptor 1, member of the class A family of seven-transmembrane G ...
119-412 1.90e-14

chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokine receptor-like 1 (also known as Chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. CMKLR1 is prominently expressed in dendritic cells and macrophages.


Pssm-ID: 320244 [Multi-domain]  Cd Length: 284  Bit Score: 74.03  E-value: 1.90e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 119 LLKVYVLAVMALFSLLGNLLTIWniyktrISRRNSRHTWSAIYSLmfHLSIADVLVTWFCIIGEAAWCYTVQWLANELTC 198
Cdd:cd15116    1 ILSMVIYSVVFVLGVLGNGLVIF------ITGFKMKKTVNTVWFL--NLAVADFLFTFFLPFSIAYTAMDFHWPFGRFMC 72
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 199 KLVKLFQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLN--MAKRCHRLLGGTYILSLVLSLPQFFIFHVARGPFVEE---F 273
Cdd:cd15116   73 KLNSFLLFLNMFTSVFLLTVISIDRCISVVFPVWSQNhrSVRLASLVSLAVWVVAFFLSSPSFIFRDTAPSQNNNKiicF 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 274 YQCVTHGFYTADWQEQMYATFTLVFT-------FLLPLCILfgtymstfrtisssekmfqgskLANYSTAKLPTQTNRqr 346
Cdd:cd15116  153 NNFSLSGDNSSPEVNQLRNMRHQVMTitrfllgFLIPFTII----------------------ICCYAAIVLKLKRNR-- 208
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 347 lIHKAKmKSLRISVVIIIAFLICWTPYYVMMI--MFMFLNPDKR--LGDDLQDAIFFfgmSNSLVNPLIY 412
Cdd:cd15116  209 -LAKSS-KPFKIIAAVIVTFFLCWAPYHILNLleMEATRSPASVfkIGLPITSSLAF---INSCLNPILY 273
7tmA_GPR119_R_insulinotropic_receptor cd15104
G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member ...
122-416 2.90e-14

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR119 is activated by oleoylethanolamide (OEA), a naturally occurring bioactive lipid with hypophagic and anti-obesity effects. Immunohistochemistry and double-immunofluorescence studies revealed the predominant GPR119 localization in pancreatic polypeptide (PP)-cells of islets. In addition, GPR119 expression is elevated in islets of obese hyperglycemic mice as compared to control islets, suggesting a possible involvement of this receptor in the development of obesity and diabetes. GPR119 has a significant sequence similarity with the members of the endothelial differentiation gene family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320232 [Multi-domain]  Cd Length: 283  Bit Score: 73.56  E-value: 2.90e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 122 VYVLAVMALFSLLGNLLTIWNIYKTRisrrnsRHTWSAIYSLMFHLSIADVLVTWFCIIGEAAWCYTVQWLANELTCKLV 201
Cdd:cd15104    3 GVILAVLSPLIITGNLLVIVALLKLI------RKKDTKSNCFLLNLAIADFLVGLAIPGLATDELLSDGENTQKVLCLLR 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 202 KLFQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLNMA--KRCHRLLGGTYILS-LVLSLPqffifhVARGPFVEEFY--QC 276
Cdd:cd15104   77 MCFVITSCAASVLSLAAIAFDRYLALKQPLRYKQIMtgKSAGALIAGLWLYSgLIGFLP------LISPQFQQTSYkgKC 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 277 vthGFYTADWQEQMYATFTLVFtflLPLCILF-GTYMSTFRTISSSEKMFQGSKLANYStAKLPTQTNRQrlihkakMKS 355
Cdd:cd15104  151 ---SFFAAFHPRVLLVLSCMVF---FPALLLFvFCYCDILKIARVHSRAIYKVEHALAR-QIHPRRTLSD-------FKA 216
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 442631927 356 LRISVVIIIAFLICWTPYYVMMIMFMFLNPDKrLGDDLQDAIFFFGMSNSLVNPLIYgAFH 416
Cdd:cd15104  217 ARTVAVLIGCFLLSWLPFQITGLVQALCDECK-LYDVLEDYLWLLGLCNSLLNPWIY-AFW 275
7tmA_AT2R cd15191
type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
124-412 3.30e-14

type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 341341 [Multi-domain]  Cd Length: 285  Bit Score: 73.63  E-value: 3.30e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 124 VLAVMALFSLLGNLLTIwniykTRISRRNSRHTWSAIYslMFHLSIADVLVTWFCIIGEAAWCYTVQWLANELTCKLVKL 203
Cdd:cd15191    6 LYSIIFILGFLGNSLVV-----CVFCHQSGPKTVASIY--IFNLAVADLLFLATLPLWATYYSYGYNWLFGSVMCKICGS 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 204 FQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLNMAKRCHRLLGG-TYILSLVLSLPQFFiFHVARgpFVEEFYQCVTHGFY 282
Cdd:cd15191   79 LLTLNLFASIFFITCMSVDRYLAVVYPLRSQRRRSWQARLVCLlVWVLACLSSLPTFY-FRDTY--YIEELGVNACIMAF 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 283 TADWQEQMYATFTL---VFTFLLPLCILFGTYMSTFRTISSSEKMfqgsklanystaklptQTNRQRLIhkakmKSLRIS 359
Cdd:cd15191  156 PNEKYAQWSAGLALmknTLGFLIPLIVIATCYFGIGRHLLKTKGF----------------GKNKQRRD-----KVLKMV 214
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 442631927 360 VVIIIAFLICWTPYYVMmimfMFLNPDKRLG-----------DDLQDAIFFFGMSNSLVNPLIY 412
Cdd:cd15191  215 AAVVLAFLICWFPFHVL----TFLDALARMGvinncwvitviDKALPFAICLGFSNSCINPFLY 274
7tmA_D1-like_dopamine_R cd15057
D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G ...
124-415 3.68e-14

D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320185 [Multi-domain]  Cd Length: 299  Bit Score: 73.62  E-value: 3.68e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 124 VLAVMALFSLLGNLLTIWNIYKTRISRRNSrhTWSAIYSLmfhlSIADVLVTWFciigeaawcyTVQWLAneltCKLVKL 203
Cdd:cd15057    6 ILYLLVLLTLLGNALVIAAVLRFRHLRSKV--TNYFIVSL----AVSDLLVAIL----------VMPWAA----VNEVAG 65
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 204 FQMFSLYLSTYV-------------LVLIGVDRWIAVKYPMKSLNMAKRCHR--LLGGTYILSLVLS-LPQFFIFHVArG 267
Cdd:cd15057   66 YWPFGSFCDVWVsfdimcstasilnLCVISVDRYWAISSPFRYERRMTRRRAfiMIAVAWTLSALISfIPVQLGWHRA-D 144
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 268 PFVEEFYQCVTHGFYTADWQeQMYATFTLVFTFLLPLCILFGTYMSTFRT-------ISSSEKMFQGSKLanystaklPT 340
Cdd:cd15057  145 DTSEALALYADPCQCDSSLN-RTYAISSSLISFYIPVAIMIVTYTRIYRIarrqirrIAALERAAQESTN--------PD 215
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 442631927 341 QTNRQRLihKAKMKSLRISVVIIIAFLICWTPYYVMMIMFMFLNPDKR----LGDDLQDAIFFFGMSNSLVNPLIYgAF 415
Cdd:cd15057  216 SSLRSSL--RRETKALKTLSIIMGVFVCCWLPFFILNCVLPFCDLRTAqfpcVPDTTFIVFVWLGWANSSLNPIIY-AF 291
7tmA_MCHR-like cd15088
melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G ...
124-412 4.29e-14

melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320216 [Multi-domain]  Cd Length: 278  Bit Score: 72.87  E-value: 4.29e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 124 VLAVMALFSLLGNLLTIWNIYktrisrRNSRHTWSA-IYslMFHLSIADVLVtwfcIIGEAAWCYTV----QWLANELTC 198
Cdd:cd15088    6 VFGCICVVGLVGNGIVLYVLV------RCSKLRTAPdIF--IFNLAVADLLF----MLGMPFLIHQFaidgQWYFGEVMC 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 199 KLVKLFQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLNMAKR--CHRLLGGTYILSLVLSLPQFFIFHVARGPFVEEFyqC 276
Cdd:cd15088   74 KIITALDANNQFTSTYILTAMSVDRYLAVVHPIRSTKYRTRfvAKLVNVGLWAASFLSILPVWVYSSLIYFPDGTTF--C 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 277 VTHGFYTADWQEQMYATFTLvfTFLLPLCILFGTYMSTFRTISSSekmfqgsklanystaklpTQTNRQRLIHKAKMKSL 356
Cdd:cd15088  152 YVSLPSPDDLYWFTIYHFIL--GFAVPLVVITVCYILILHRLARG------------------VAPGNQSHGSSRTKRVT 211
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 442631927 357 RISVVIIIAFLICWTPYYVMMIMFMFLNPDKRLGDDLQDAIFFFGMSNSLVNPLIY 412
Cdd:cd15088  212 KMVILIVVVFIVCWLPFHVVQLVNLAMNRPTLAFEVAYFLSICLGYANSCLNPFVY 267
7tmA_Delta_opioid_R cd15089
opioid receptor subtype delta, member of the class A family of seven-transmembrane G ...
125-412 4.29e-14

opioid receptor subtype delta, member of the class A family of seven-transmembrane G protein-coupled receptors; The delta-opioid receptor binds the endogenous pentapeptide ligands such as enkephalins and produces antidepressant-like effects. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320217 [Multi-domain]  Cd Length: 281  Bit Score: 73.06  E-value: 4.29e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 125 LAVMALFS------LLGNLLTIWNIYktrisRRNSRHTWSAIYslMFHLSIADVLVTWFCIIGEAAWCYTVqWLANELTC 198
Cdd:cd15089    1 IAITALYSvvcvvgLLGNVLVMYGIV-----RYTKMKTATNIY--IFNLALADALATSTLPFQSAKYLMET-WPFGELLC 72
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 199 KLVKLFQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLNM-----AKRCHRLLggtYILSLVLSLPqFFIFHVARGPfvEEF 273
Cdd:cd15089   73 KAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFrtpakAKLINICI---WVLSSGVGVP-IMVMAVTKTP--RDG 146
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 274 YQCVTHGFYTADWQ-EQMYATFTLVFTFLLPLCIL---FGTYMSTFRTIssseKMFQGSKLANYSTAKLPtqtnrqrlih 349
Cdd:cd15089  147 AVVCMLQFPSPSWYwDTVTKICVFIFAFVVPILVItvcYGLMILRLRSV----RLLSGSKEKDRNLRRIT---------- 212
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 442631927 350 kakmkslRISVVIIIAFLICWTPYYVMMIMFMFLNPDKRlgDDLQDAIFFF----GMSNSLVNPLIY 412
Cdd:cd15089  213 -------RMVLVVVAAFIICWTPIHIFVIVWTLVDIDRR--NPLVVAALHLcialGYANSSLNPVLY 270
7tmA_NPY4R cd15397
neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G ...
126-413 1.03e-13

neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320519 [Multi-domain]  Cd Length: 293  Bit Score: 72.08  E-value: 1.03e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 126 AVMALfSLLGNLLTIwniykTRISRRNSRHTWSAIysLMFHLSIADVLVTWFCIIGEAAWCYTVQWLANELTCKLVKLFQ 205
Cdd:cd15397    9 LVMAV-GLLGNICLI-----CVIARQKEKTNVTNI--LIANLSFSDILVCLVCLPFTVVYTLMDYWIFGEVLCKMTPFIQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 206 MFSLYLSTYVLVLIGVDRWIAVKYPMKSLNMAKRCHRLLGGTYILSLVLSLPqFFIFHVargpFVEEFYQCVTHGFY--- 282
Cdd:cd15397   81 CMSVTVSILSLVLIALERHQLIINPTGWKPSVSQAYLAVVVIWMLACFISLP-FLAFHI----LTDEPYKNLSHFFApla 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 283 -----TADWQEQ----MYATFTLVFTFLLPLCILFGTYMSTFRTISSSEKMFQgsklanystaklptqtnRQRLIHKAKM 353
Cdd:cd15397  156 dkavcTESWPSEhhklAYTTWLLLFQYCLPLLFILVCYLRIYLRLRRRKDMLE-----------------RRGEYNRRAG 218
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 442631927 354 KSLRISVV---IIIAFLICWTPYYVMMIMFMFlNPdKRLGDDLQDAIF----FFGMSNSLVNPLIYG 413
Cdd:cd15397  219 HSKRINVMlvsLVAAFALCWLPLNVFNAIADW-NH-EAIPHCQHNLIFslchLAAMASTCVNPIIYG 283
7tmA_C3aR cd15115
complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of ...
119-412 1.13e-13

complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320243 [Multi-domain]  Cd Length: 265  Bit Score: 71.72  E-value: 1.13e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 119 LLKVYVLAVMALFSLLGNLLTIWniyktrISRRNSRHTWSAIYSLmfHLSIADVLVTWFCIIGEAAWCYTVQWLANELTC 198
Cdd:cd15115    1 ILSLVVLSLTFLLGVPGNGLVIW------VAGLKMKRTVNTIWFL--NLAVADLLCCLSLPFSIAHLLLNGHWPYGRFLC 72
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 199 KLVKLFQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLNmakrcHR-------LLGGTYILSLVLSLPQFfifhVARGPFVE 271
Cdd:cd15115   73 KLLPSIIVLNMFASVFTLTAISLDRFLLVIKPVWAQN-----HRsvllaclLCGCIWILALLLCLPVF----IYRTTVTD 143
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 272 EFYQCVTHGFYTAdwqeqmyATFT-LVFTFLLPLCILFGTYMSTFRtissseKMFQGSKlanystaklptqtnrqrliHK 350
Cdd:cd15115  144 GNHTRCGYDFLVA-------ITITrAVFGFLLPLLIIAACYSFIAF------RMQRGRF-------------------AK 191
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 442631927 351 AKMKSLRISVVIIIAFLICWTPYYVMMIMFMFLNPDK----RLGDDLQDAIFFfgmSNSLVNPLIY 412
Cdd:cd15115  192 SQSKTFRVIIAVVVAFFVCWAPYHIIGILSLYGDPPLskvlMSWDHLSIALAY---ANSCLNPVLY 254
7tmA_ET_R-like cd14977
endothelin receptors and related proteins, member of the class A family of seven-transmembrane ...
123-411 1.24e-13

endothelin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes endothelin receptors, bombesin receptor subtype 3 (BRS-3), gastrin-releasing peptide receptor (GRPR), neuromedin B receptor (NMB-R), endothelin B receptor-like 2 (ETBR-LP-2), and GRP37. The endothelin receptors and related proteins are members of the seven transmembrane rhodopsin-like G-protein coupled receptor family (class A GPCRs) which activate multiple effectors via different types of G protein.


Pssm-ID: 320108 [Multi-domain]  Cd Length: 292  Bit Score: 72.07  E-value: 1.24e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 123 YVLAVMALF----SLLGNLLTIWNIYKTRISRrnsrhtwSAIYSLMFHLSIADVLVTWFCIIGEAAWCYTVQWLANELTC 198
Cdd:cd14977    1 YVIMSLSLVifavGIIGNLMVLCIVCTNYYMR-------SVPNILIASLALGDLLLLLLCVPLNAYNLLTKDWLFGDVMC 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 199 KLVKLFQMFSLYLSTYVLVLIGVDRWIAVKYPMKsLNMAKRCHRL---LGGTYILSLVLSLPQFFIFHVARGPFVEEFYQ 275
Cdd:cd14977   74 KLVPFIQVTSLGVTVFSLCALSIDRYRAAVNSMP-MQTIGACLSTcvkLAVIWVGSVLLAVPEAVLSTVARESSLDNSSL 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 276 CVThGFYTADWQEQMYATFTLV----FTFLLPLCILFGTYMSTFRTISSSEKmfqGSKLANYSTAKLPTQTNrqrlihka 351
Cdd:cd14977  153 TVC-IMKPSTPFAETYPKARSWwlfgCYFCLPLAFTAVCYLLMARTLIRAAK---EYTRGTKKHMKQRRQLA-------- 220
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 442631927 352 kmkslRISVVIIIAFLICWTPYYVMMIMFMFL----NPDKRLGDDLQDAI-FFFGMSNSLVNPLI 411
Cdd:cd14977  221 -----KTVLCLVLVFAFCWLPEHISNILRATLynevLIDTRSTLDILDLIgQFLSFFNSCVNPIA 280
7tmA_CXCR3 cd15180
CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
154-412 2.06e-13

CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR3 is an inflammatory chemotactic receptor for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. CXCR3 specifically binds three chemokines CXCL9 (monokine induced by gamma-interferon), CXCL10 (interferon induced protein of 10 kDa), and CXCL11 (interferon inducible T-cell alpha-chemoattractant, I-TAC). CXC3R is expressed on CD4+ Th1 and CD8+ cytotoxic T lymphocytes as well as highly on innate lymphocytes, such as NK cells and NK T cells, where it may mediate the recruitment of these cells to the sites of infection and inflammation. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341335 [Multi-domain]  Cd Length: 280  Bit Score: 70.87  E-value: 2.06e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 154 RHTWSAIYSLMFHLSIADVL--VTWFCIIGEAAwcytVQWLANELTCKLVKLFQMFSLYLSTYVLVLIGVDRWI----AV 227
Cdd:cd15180   29 RRNLSVTDTFILHLALADILllVTLPFWAVQAV----HGWIFGTGLCKLAGAVFKINFYCGIFLLACISFDRYLsivhAV 104
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 228 KYPMKSLNMAKRCHRLLggTYILSLVLSLPQFfIFHVARGPFVEEFYQCVtHGFYTADWQEQMYATFT-LVFTFLLPLCI 306
Cdd:cd15180  105 QMYSRKKPMLVHLSCLI--VWLFCLLLSIPDF-IFLEATKDPRQNKTECV-HNFPQSDTYWWLALRLLyHIVGFLLPLAV 180
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 307 LFGTYMSTFRTISSSEKMFQgsklanystaklptqtnrqrlihkaKMKSLRISVVIIIAFLICWTPYYVMMIMFMFLNPD 386
Cdd:cd15180  181 MVYCYTSILLRLLRSSQGFQ-------------------------KQRAIRVIVAVVVVFFLCWTPYNIALLVDTLIDLS 235
                        250       260       270
                 ....*....|....*....|....*....|....
gi 442631927 387 KRLGDDLQDAIF--------FFGMSNSLVNPLIY 412
Cdd:cd15180  236 VLDRNCGTESRLdialsvtsSLGYFHCCLNPLLY 269
7tmA_alpha1_AR cd15062
alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G ...
124-412 2.40e-13

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320190 [Multi-domain]  Cd Length: 261  Bit Score: 70.60  E-value: 2.40e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 124 VLAVMALFSLLGNLLTIwniyktrISRRNSRHTWSAIYSLMFHLSIADVLVTWFCIIGEAAWCYTVQWLANELTCKLVKL 203
Cdd:cd15062    6 ALGAFILFAIGGNLLVI-------LSVACNRHLRTPTHYFIVNLAVADLLLSFTVLPFSATLEVLGYWAFGRIFCDVWAA 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 204 FQMFSLYLSTYVLVLIGVDRWIAVKYPMK--SLNMAKRCHRLLGGTYILSLVLSLPQFFIFhvaRGPFVEEFYQCVTHgf 281
Cdd:cd15062   79 VDVLCCTASIMSLCVISVDRYIGVRYPLNypTIVTARRATVALLIVWVLSLVISIGPLLGW---KEPAPADEQACGVN-- 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 282 ytadwQEQMYATFTLVFTFLLPLCILFGTYMSTFRTisssekMFQGSKlanystaklptqtnrqrliHKAKMKSLRIsvv 361
Cdd:cd15062  154 -----EEPGYVLFSSLGSFYLPLAIILVMYCRVYVV------AFKFSR-------------------EKKAAKTLGI--- 200
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 442631927 362 IIIAFLICWTPYYVMMIMFMFLnPDKRLGDDLQDAIFFFGMSNSLVNPLIY 412
Cdd:cd15062  201 VVGAFVLCWFPFFVVLPLGSLF-STLKPPEPVFKVVFWLGYFNSCLNPIIY 250
7tmA_Melanopsin cd15336
vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G ...
124-416 3.47e-13

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G protein-coupled receptors; Melanopsin (also called Opsin-4) is the G protein-coupled photopigment that mediates non-visual responses to light. In mammals, these photoresponses include the photo-entrainment of circadian rhythm, pupillary constriction, and acute nocturnal melatonin suppression. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. Melanopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320458 [Multi-domain]  Cd Length: 290  Bit Score: 70.52  E-value: 3.47e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 124 VLAVMALFSLLGNLLTIWNIYKTRISRrnsrhtwSAIYSLMFHLSIADVLVTwfciIGEAAWCYTV----QWLANELTCK 199
Cdd:cd15336    6 VILIIGITGMLGNALVIYAFCRSKKLR-------TPANYFIINLAVSDFLMS----LTQSPIFFVNslhkRWIFGEKGCE 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 200 LVKLFQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLNMA--KRCHRLLGGTYILSLVLSLPQFFifhvARGPFVEEfyqcv 277
Cdd:cd15336   75 LYAFCGALFGITSMITLLAISLDRYLVITKPLASIRWVskKRAMIIILLVWLYSLAWSLPPLF----GWSAYVPE----- 145
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 278 thGFYTA-DWQeqmYATFTL----------VFTFLLPLCILFGTYMSTFRTISSSEKMFQgsklanystaKLPTQTNRQR 346
Cdd:cd15336  146 --GLLTScTWD---YMTFTPsvraytmllfCFVFFIPLGIIIYCYLFIFLAIRSTGREVQ----------KLGSQDRKEK 210
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 442631927 347 LIHKAKMKS----LRISVVIIIAFLICWTPYYVMMiMFMFLNPDKRLGDDLQDAIFFFGMSNSLVNPLIYGAFH 416
Cdd:cd15336  211 AKQYQRMKNewkmAKIAFVVILLFVLSWSPYACVA-LIAWAGYAHLLTPYMKSVPAVIAKASAIYNPIIYAITH 283
7tmA_SSTR cd15093
somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
123-413 6.04e-13

somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. They share common signaling cascades such as inhibition of adenylyl cyclase, activation of phosphotyrosine phosphatase activity, and G-protein-dependent regulation of MAPKs.


Pssm-ID: 320221 [Multi-domain]  Cd Length: 280  Bit Score: 69.80  E-value: 6.04e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 123 YVLAVMALFSLLGNLLTIWNIYktrisRRNSRHTWSAIYSLmfHLSIADVLVTwFCIIGEAAWCYTVQWLANELTCKLVK 202
Cdd:cd15093    5 CIYAVVCLVGLCGNSLVIYVVL-----RYAKMKTVTNIYIL--NLAIADELFM-LGLPFLAASNALRHWPFGSVLCRLVL 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 203 LFQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLNMAK-RCHRLLG-GTYILSLVLSLPQFFIFHVARGPfvEEFYQCVTHG 280
Cdd:cd15093   77 SVDGINMFTSIFCLTVMSVDRYLAVVHPIKSARWRRpRVAKVVNlAVWVASLLVILPVVVFAGTRENQ--DGSSACNMQW 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 281 FYTADWQEQMYATFTLVFTFLLPLCILFGTYMSTFRTISSSekmfqgsklanystAKLPTQTNRQRlihkAKMKSLRISV 360
Cdd:cd15093  155 PEPAAAWSAGFIIYTFVLGFLLPLLIICLCYLLIVIKVKSA--------------GLRAGWQQRKR----SERKVTRMVV 216
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 442631927 361 VIIIAFLICWTPYYVMMI--MFMFLNPDKRLGdDLQDAIFFFGMSNSLVNPLIYG 413
Cdd:cd15093  217 MVVVVFVICWLPFYVLQLvnVFVQLPETPALV-GVYHFVVILSYANSCANPILYG 270
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
79-381 6.32e-13

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 70.19  E-value: 6.32e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927  79 YAISNSSSLAHTNSRHEAPPMAEQVPEHVMDHAPQLSRSGLLKVYVLavMALFSLLGNLLTIWNIYKTRISrrnsrhTWS 158
Cdd:PHA03087   3 YTLTINTTIENTTDYYYDTYYDEDYADCDLNIGYDTNSTILIVVYST--IFFFGLVGNIIVIYVLTKTKIK------TPM 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 159 AIYSLmfHLSIADVLVTW---FCIIgeaaWCYTVQWLANELTCKLVKLFQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLN 235
Cdd:PHA03087  75 DIYLL--NLAVSDLLFVMtlpFQIY----YYILFQWSFGEFACKIVSGLYYIGFYNSMNFITVMSVDRYIAIVHPVKSNK 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 236 M--AKRCHRLLGGTYILSLVLSLPQFFIFHVARgpfVEEFYQCvtHGFYTAD---WqeQMYATFTL-VFTFLLPLCILFG 309
Cdd:PHA03087 149 IntVKYGYIVSLVIWIISIIETTPILFVYTTKK---DHETLIC--CMFYNNKtmnW--KLFINFEInIIGMLIPLTILLY 221
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 442631927 310 TYMSTFRTISSSEKmfqgsklanystaklptqtnrqrliHKAKMKSLRISVVIIIAFLICWTPYYVMMIMFM 381
Cdd:PHA03087 222 CYSKILITLKGINK-------------------------SKKNKKAIKLVLIIVILFVIFWLPFNVSVFVYS 268
7tmA_NK1R cd16002
neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled ...
126-412 7.62e-13

neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neurokinin 1 receptor (NK1R), also known as tachykinin receptor 1 (TACR1) or substance P receptor (SPR), is a G-protein coupled receptor found in the mammalian central nervous and peripheral nervous systems. The tachykinins act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. SP is an extremely potent vasodilator through endothelium dependent mechanism and is released from the autonomic sensory nerves. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320668 [Multi-domain]  Cd Length: 284  Bit Score: 69.51  E-value: 7.62e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 126 AVMALFSLLGNLLTIWNIYKTRISRRNSRHtwsaiysLMFHLSIADVLVTWFCIIGEAAWCYTVQWLANELTCKLVKLFQ 205
Cdd:cd16002    8 SVIVVVSVVGNIIVMWIILAHKRMRTVTNY-------FLVNLAFAEASMSAFNTVINFTYAIHNEWYYGLEYCKFHNFFP 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 206 MFSLYLSTYVLVLIGVDRWIAVKYPMKSLNMAKRCHRLLGGTYILSLVLSLPQFFIFHVARGPfvEEFYQCVTHGFYTAD 285
Cdd:cd16002   81 IAAVFASIYSMTAIALDRYMAIIHPLQPRLSATATKVVICVIWVLAFLLAFPQGYYSDTEEMP--GRVVCYVEWPEHEER 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 286 WQEQMYATFTLVFTFLLPLCILFGTYMSTFRTISSSEkmfqgsklanystakLP-TQTNRQRLIHKAKMKSLRISVVIII 364
Cdd:cd16002  159 KYETVYHVCVTVLIYFLPLLVIGCAYTVVGITLWASE---------------IPgDSSDRYHEQVSAKRKVVKMMIVVVC 223
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 442631927 365 AFLICWTPYYVMMIMFMFlNPDKRLGDDLQD---AIFFFGMSNSLVNPLIY 412
Cdd:cd16002  224 TFAICWLPYHIYFLLQYF-HPELYEQKFIQQvylAIMWLAMSSTMYNPIIY 273
7tmA_Mu_opioid_R cd15090
opioid receptor subtype mu, member of the class A family of seven-transmembrane G ...
122-413 8.11e-13

opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors; The mu-opioid receptor binds endogenous opioids such as beta-endorphin and endomorphin. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320218 [Multi-domain]  Cd Length: 279  Bit Score: 69.25  E-value: 8.11e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 122 VYVLAVMALFSLLGNLLTIWNIYktrisRRNSRHTWSAIYslMFHLSIADVLVTWFCIIGEAAWCYTVQWLANELtCKLV 201
Cdd:cd15090    4 MALYSIVCVVGLFGNFLVMYVIV-----RYTKMKTATNIY--IFNLALADALATSTLPFQSVNYLMGTWPFGNIL-CKIV 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 202 KLFQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLNM-AKRCHRLLG-GTYILSLVLSLPQFFIfhvARGPFVEEFYQCVTH 279
Cdd:cd15090   76 ISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFrTPRNAKIVNvCNWILSSAIGLPVMFM---ATTKYRQGSIDCTLT 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 280 GFYTADWQEQMYATFTLVFTFLLPLCILFGTY-MSTFRTisSSEKMFQGSKlanystaklPTQTNRQRLIhkakmkslRI 358
Cdd:cd15090  153 FSHPSWYWENLLKICVFIFAFIMPVLIITVCYgLMILRL--KSVRMLSGSK---------EKDRNLRRIT--------RM 213
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 442631927 359 SVVIIIAFLICWTPYYVMMIMFMFLN-PDKRLGDDLQDAIFFFGMSNSLVNPLIYG 413
Cdd:cd15090  214 VLVVVAVFIVCWTPIHIYVIIKALVTiPETTFQTVSWHFCIALGYTNSCLNPVLYA 269
7tmA_GPR151 cd15002
G protein-coupled receptor 151, member of the class A family of seven-transmembrane G ...
124-414 8.19e-13

G protein-coupled receptor 151, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 151 (GRP151) is an orphan receptor of unknown function. Its expression is conserved in habenular axonal projections of vertebrates and may be a promising novel target for psychiatric drug development. GPR151 shows high sequence similarity with galanin receptors (GALR). GPR151 is a member of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320133 [Multi-domain]  Cd Length: 280  Bit Score: 69.36  E-value: 8.19e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 124 VLAVMALFSLLGNLLTIWNIyktrISRRNsRHTWSAIYSLMFHLSIADVLVTWFCIIGEAAwCYTVQ-WLANELTCKLVK 202
Cdd:cd15002    5 LLGVICLLGFAGNLMVIGIL----LNNAR-KGKPSLIDSLILNLSAADLLLLLFSVPFRAA-AYSKGsWPLGWFVCKTAD 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 203 LFQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLNMA-KRCHRLLGGTYILSLVLSLPQFFIFHVARgpfVEEFYQCVTHGF 281
Cdd:cd15002   79 WFGHACMAAKSFTIAVLAKACYMYVVNPTKQVTIKqRRITAVVASIWVPACLLPLPQWLFRTVKQ---SEGVYLCILCIP 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 282 YTADWQEQMYATFTLVFTFLLPLCILFGTYMSTFRTIsssekmfQGSKLAnysTAKLPTQTNRQRLIHkakmkslrISVV 361
Cdd:cd15002  156 PLAHEFMSAFVKLYPLFVFCLPLTFALFYFWRAYGQC-------QRRGTK---TQNLRNQIRSRKLTH--------MLLS 217
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 442631927 362 IIIAFLICWTPYYVMMIMFMFL---NPDKRLGDDLQDAIFFFgmSNSLVNPLIYGA 414
Cdd:cd15002  218 VVLAFTILWLPEWVAWLWLIHIkssGSSPPQLFNVLAQLLAF--SISSVNPIIFLL 271
7tmA_Adenosine_R cd14968
adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...
122-417 9.34e-13

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.


Pssm-ID: 341316 [Multi-domain]  Cd Length: 285  Bit Score: 69.21  E-value: 9.34e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 122 VYVLA--VMALFSLLGNLLTIWNIYKTRISRRNSRHtwsaiysLMFHLSIADVLVTWFCI-------IGEAAWCYTVQWL 192
Cdd:cd14968    2 VYIVLevLIAVLSVLGNVLVIWAVKLNRALRTVTNY-------FIVSLAVADILVGALAIplailisLGLPTNFHGCLFM 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 193 AneltCKLVKLFQMfslylSTYVLVLIGVDRWIAVKYPM--KSLNMAKRCHRLLGGTYILSLVLSL-PQF--FIFHVARG 267
Cdd:cd14968   75 A----CLVLVLTQS-----SIFSLLAIAIDRYLAIKIPLryKSLVTGRRAWGAIAVCWVLSFLVGLtPMFgwNNGAPLES 145
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 268 PFVEEFYQCVTHGFYTADWqeqmYATFTLVFTFLLPLCILFGTYMSTFRTISSSEKmfQGSklanYSTAKLPTQTNRQRL 347
Cdd:cd14968  146 GCGEGGIQCLFEEVIPMDY----MVYFNFFACVLVPLLIMLVIYLRIFRVIRKQLR--QIE----SLLRSRRSRSTLQKE 215
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 348 IHKAkmKSLRIsvvIIIAFLICWTPYYVMMiMFMFLNPDKRLGDDLQDAIFFFGMSNSLVNPLIYgAFHL 417
Cdd:cd14968  216 VKAA--KSLAI---ILFLFALCWLPLHIIN-CITLFCPECKVPKILTYIAILLSHANSAVNPIVY-AYRI 278
7tmA_Adenosine_R_A2A cd15068
adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G ...
119-412 1.04e-12

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2A receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320196 [Multi-domain]  Cd Length: 293  Bit Score: 69.20  E-value: 1.04e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 119 LLKVYVLAVMALFSLLGNLLTIWNIYktrisrRNSrHTWSAIYSLMFHLSIADVLV----TWFCIIGEAAWCytvqwlAN 194
Cdd:cd15068    1 SVYITVELAIAVLAILGNVLVCWAVW------LNS-NLQNVTNYFVVSLAAADIAVgvlaIPFAITISTGFC------AA 67
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 195 ELTCKLVKLFQMFSLYLSTYVLVLIGVDRWIAVKYPMK--SLNMAKRCHRLLGGTYILSLVLSLPQFFIFHVARGPFVEE 272
Cdd:cd15068   68 CHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRynGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGK 147
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 273 FY-QCVTHGFYTADWQEQMYATFTLVFTF----LLPLCILFGTYMSTFRTISSSEKMFQGSklanySTAKLPTQTNRQRL 347
Cdd:cd15068  148 NHsQGCGEGQVACLFEDVVPMNYMVYFNFfacvLVPLLLMLGVYLRIFLAARRQLKQMESQ-----PLPGERARSTLQKE 222
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 442631927 348 IHKAKmkslriSVVIIIA-FLICWTPYYVMMIMFMFLNPDKRLGDDLQDAIFFFGMSNSLVNPLIY 412
Cdd:cd15068  223 VHAAK------SLAIIVGlFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIY 282
7tmA_Trissin_R cd15012
trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...
133-415 1.21e-12

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320140 [Multi-domain]  Cd Length: 277  Bit Score: 68.62  E-value: 1.21e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 133 LLGNLLTIWNIYKTRISRrnsrhtwSAIYSLMFHLSIADVLVTWFCIIGEAAWCYTVQWLANELTCKLVKLFQMFSLYLS 212
Cdd:cd15012   14 FFGNLLVILVVTSHRRMR-------TITNFFLANLAVADLCVGIFCVLQNLSIYLIPSWPFGEVLCRMYQFVHSLSYTAS 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 213 TYVLVLIGVDRWIAVKYPMKSLNMAKRCHRLLGG--TYILSLVLSLPQFFIFHVARGPFVEEFYQCVTHGFYTADWQEQM 290
Cdd:cd15012   87 IGILVVISVERYIAILHPLRCKQLLTAARLRVTIvtVWLTSAVYNTPYFVFSQTVEILVTQDGQEEEICVLDREMFNSKL 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 291 YATFTLVFTFLLPLCILFGTYMSTFRTISSSekmfqgsklanystaklptQTNRQRlihkakMKSLRISVVIIIAFLICW 370
Cdd:cd15012  167 YDTINFIVWYLIPLLIMTVLYSKISIVLWKS-------------------SSIEAR------RKVVRLLVAVVVSFALCN 221
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 442631927 371 TPYYVMMIMFMFLNP---DKRLGDDLQDAIFFFGMSNSLVNPLIYGAF 415
Cdd:cd15012  222 LPYHARKMWQYWSEPyrcDSNWNALLTPLTFLVLYFNSAVNPLLYAFL 269
7tmA_UII-R cd14999
urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled ...
124-412 1.33e-12

urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The urotensin-II receptor (UII-R, also known as the hypocretin receptor) is a member of the class A rhodopsin-like G-protein coupled receptors, which binds the peptide hormone urotensin-II. Urotensin II (UII) is a vasoactive somatostatin-like or cortistatin-like peptide hormone. However, despite the apparent structural similarity to these peptide hormones, they are not homologous to UII. Urotensin II was first identified in fish spinal cord, but later found in humans and other mammals. In fish, UII is secreted at the back part of the spinal cord, in a neurosecretory centre called uroneurapophysa, and is involved in the regulation of the renal and cardiovascular systems. In mammals, urotensin II is the most potent mammalian vasoconstrictor identified to date and causes contraction of arterial blood vessels, including the thoracic aorta. The urotensin II receptor is a rhodopsin-like G-protein coupled receptor, which binds urotensin-II. The receptor was previously known as GPR14, or sensory epithelial neuropeptide-like receptor (SENR). The UII receptor is expressed in the CNS (cerebellum and spinal cord), skeletal muscle, pancreas, heart, endothelium and vascular smooth muscle. It is involved in the pathophysiological control of cardiovascular function and may also influence CNS and endocrine functions. Binding of urotensin II to the receptor leads to activation of phospholipase C, through coupling to G(q/11) family proteins. The resulting increase in intracellular calcium may cause the contraction of vascular smooth muscle.


Pssm-ID: 320130 [Multi-domain]  Cd Length: 282  Bit Score: 68.62  E-value: 1.33e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 124 VLAVMALFSLLGNLLTIWnIYKTRISRRNSRHTWS---AIYSLMFHLSIADVLVTWFciigeaawcyTVQWLANELTCKL 200
Cdd:cd14999    5 VLSLMCVVGVAGNVYTLV-VMCLSMRPRASMYVYIlnlALADLLYLLTIPFYVSTYF----------LKKWYFGDVGCRL 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 201 VKLFQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLNMAKRCHRLL-GGTYILSLVLSLPQFFIFHVARG--PFVEEFYQCV 277
Cdd:cd14999   74 LFSLDFLTMHASIFTLTVMSTERYLAVVKPLDTVKRSKSYRKLLaGVIWLLSLLLTLPMAIMIRLVTVedKSGGSKRICL 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 278 THgfytadWQEQ---MYATFTLVFTFLLPLCILFGTYMSTFRTISSSEkmfqgSKLANYSTAKLPTQtnrqrlihkakmK 354
Cdd:cd14999  154 PT------WSEEsykVYLTLLFSTSIVIPGLVIGYLYIRLARKYWLSQ-----AAASNSSRKRLPKQ------------K 210
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 442631927 355 SLRISVVIIIAFLICWTPYYVMMIMFMFlNPDKRLGDDLQDAIFFF----GMSNSLVNPLIY 412
Cdd:cd14999  211 VLKMIFTIVLVFWACFLPFWIWQLLYLY-SPSLSLSPRTTTYVNYLltclTYSNSCINPFLY 271
7tmA_photoreceptors_insect cd15079
insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...
123-416 1.36e-12

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320207 [Multi-domain]  Cd Length: 292  Bit Score: 68.76  E-value: 1.36e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 123 YVLAVMALF----SLLGNLLTIWnIYKTRISRRnsrhTWSAIysLMFHLSIADVLV---TWFCIIGeaawCYTVQWLANE 195
Cdd:cd15079    1 YLLGFIYIFlgivSLLGNGLVIY-IFSTTKSLR----TPSNM--LVVNLAISDFLMmikMPIFIYN----SFYEGWALGP 69
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 196 LTCKLVKLFQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLNM-AKRCHRLLGGTYILSLVLS-LPQFFIFhvarGPFVEEF 273
Cdd:cd15079   70 LGCQIYAFLGSLSGIGSIWTNAAIAYDRYNVIVKPLNGNPLtRGKALLLILFIWLYALPWAlLPLLFGW----GRYVPEG 145
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 274 Y--QCvTHGFYTADWQEQMYATFTLVFTFLLPLCILFGTYMSTFRTISSSEKMF--QGSKLANYSTakLPTQTNRQRlih 349
Cdd:cd15079  146 FltSC-SFDYLTRDWNTRSFVATIFVFAYVIPLIIIIYCYSFIVKAVFAHEKALreQAKKMNVVSL--RSNADANKQ--- 219
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 442631927 350 KAKMKSLRISVVIIIAFLICWTPYYVMMIMFMFLNpdkrlgddlQDAI--------FFFGMSNSLVNPLIYGAFH 416
Cdd:cd15079  220 SAEIRIAKVALTNVFLWFIAWTPYAVVALIGAFGN---------QSLLtplvsmipALFAKTAACYNPIVYAISH 285
7tmA_5-HT7 cd15329
serotonin receptor subtype 7, member of the class A family of seven-transmembrane G ...
124-415 1.73e-12

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT7 receptor, one of 14 mammalian serotonin receptors, is a member of the class A of GPCRs and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT7 receptor mainly couples to Gs protein, which positively stimulates adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. 5-HT7 receptor is expressed in various human tissues, mainly in the brain, the lower gastrointestinal tract and in vital blood vessels including the coronary artery. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320452 [Multi-domain]  Cd Length: 260  Bit Score: 68.07  E-value: 1.73e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 124 VLAVMALFSLLGNLLTIWNIYKTRISRRNSRHtwsaiysLMFHLSIAD----VLVTWFCIIGEaawcYTVQWLANELTCK 199
Cdd:cd15329    6 VLLIIILGTVVGNALVIIAVCLVKKLRTPSNY-------LIVSLAVSDllvaLLVMPLAIIYE----LSGYWPFGEILCD 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 200 LVKLFQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLnmAKRCHRLLGG----TYILSLVLSLPQFFIFhvarGPFVEEFYQ 275
Cdd:cd15329   75 VWISFDVLLCTASILNLCAISVDRYLVITRPLTYA--VKRTPKRMALmiaiVWLLSALISIPPLFGW----KNKVNDPGV 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 276 CvthgFYTADWQEQMYATFtlvFTFLLPLCILFGTYMSTFRtISSSEkmfqgsklanystaklptqtnrqrlihkakMKS 355
Cdd:cd15329  149 C----QVSQDFGYQIYATF---GAFYIPLIVMLVLYYKIYR-AAKSE------------------------------RKA 190
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 442631927 356 LRISVVIIIAFLICWTPYYVMMIM--FMFLNPDKRLGDDLQDAIFFFGMSNSLVNPLIYGAF 415
Cdd:cd15329  191 IKTLGIIMGAFTLCWLPFFILALLrpFLKPIKCSCIPLWLSRLFLWLGYANSFLNPIIYAKF 252
7tmA_tyramine_R-like cd15061
tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
124-413 1.84e-12

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine-specific receptors and similar proteins found in insects and other invertebrates. These tyramine receptors form a distinct receptor family that is phylogenetically different from the other tyramine/octopamine receptors which also found in invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320189 [Multi-domain]  Cd Length: 256  Bit Score: 67.77  E-value: 1.84e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 124 VLAVMALFSLLGNLLTIWNIYKTRISRRNSRhtwsaiySLMFHLSIADVLVTWFCIIGEAAWCYTVQWLANELTCKLVKL 203
Cdd:cd15061    5 FLILAIIFTIFGNLLVILAVATTRRLRTITN-------CYIVSLATADLLVGVLVLPLAIIRQLLGYWPLGSHLCDFWIS 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 204 FQMFSLYLSTYVLVLIGVDRWIAVKYPMKSlnMAKRCHRL----LGGTYILSLVLSLPQFFIfhvARGPFVEEFYQCvth 279
Cdd:cd15061   78 LDVLLCTASILNLCCISLDRYFAITYPLKY--RTKRSRRLaitmILAVWVISLLITSPPLVG---PSWHGRRGLGSC--- 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 280 gFYTADwqeQMYATFTLVFTFLLPLCILFGTYMSTFRTIsssekmfqgsklanystaklptqtNRQRlihkakmKSLRIS 359
Cdd:cd15061  150 -YYTYD---KGYRIYSSMGSFFLPLLLMLFVYLRIFRVI------------------------AKER-------KTAKTL 194
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 442631927 360 VVIIIAFLICWTPYYVMMIMFMFLnpDKRLGDDLQDAIFFFGMSNSLVNPLIYG 413
Cdd:cd15061  195 AIVVGCFIVCWLPFFIMYLIEPFC--DCQFSEALSTAFTWLGYFNSVINPFIYA 246
7tmA_ACKR3_CXCR7 cd14987
CXC chemokine receptor 7, member of the class A family of seven-transmembrane G ...
123-412 1.95e-12

CXC chemokine receptor 7, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR3, also known as CXCR7, is an atypical chemokine receptor for CXCL12 and CXCR11. Unlike the classical chemokine receptors, ACKR3 contains a DRYLSIT-sequence instead of the conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. Thus, ACKR3 does not activate classical GPCR signaling, instead induces beta-arrestin recruitment which is leading to ligand internalization and MAP-kinase activation. It is acting as a scavenger for CXCL12 and, to a lesser degree, for CXCL11. ACKR3 is highly expressed by blood vascular endothelial cells in brain, in numerous embryonic and neonatal tissues, in inflamed tissues and in a variety of cancers such as lymphomas, sarcomas, prostate and breast cancers, and gliomas. Five receptors have been identified for the ACKR family, including CC-Chemokine Receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, DARC, and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320118 [Multi-domain]  Cd Length: 282  Bit Score: 68.25  E-value: 1.95e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 123 YVLAVMALF----SLLGNLLTIWNIYKTRISRRNSrHTWsaiyslMFHLSIADVLVTWFCIIGEAAWCYTVQWLANELTC 198
Cdd:cd14987    1 YTLSFFYIFifviGLLANSVVVWVNLQAKRTGYET-HLY------ILNLAIADLCVVATLPVWVVSLVQHNQWPMGEFTC 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 199 KLVKLFQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLNMAKRCHRLL--GGTYILSLVLSLPQFFIFHVARGPFVEEFYQC 276
Cdd:cd14987   74 KITHLIFSINLFGSIFFLTCMSVDRYLSVTLFGNTSSRRKKIVRRIicVLVWLLAFVASLPDTYFLKTVTSPSNNETYCR 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 277 VTHGFYT-ADWQEQMYATFtLVFTFLLPLCILFGTYMSTFRTISSSekmfqgsklanystaklptqTNRQRLIhkakmkS 355
Cdd:cd14987  154 SFYPEESfKEWLIGMELVS-IVLGFVIPFPIIAVFYFLLARAISAS--------------------SDQERKS------S 206
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 442631927 356 LRISVVIIIAFLICWTPYYVMMIM--FMFLN--PdkrLGDDLQDAIFF-------FGMSNSLVNPLIY 412
Cdd:cd14987  207 RKIIFSYVVVFLVCWLPYHTVVLLdiLSFLHliP---FSCQLENFLYAalhvtqcFSLVHCCVNPILY 271
7tmA_5-HT1A_invertebrates cd15331
serotonin receptor subtype 1A from invertebrates, member of the class A family of ...
124-416 1.96e-12

serotonin receptor subtype 1A from invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320454 [Multi-domain]  Cd Length: 261  Bit Score: 67.76  E-value: 1.96e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 124 VLAVMALFSLLGNLLTIWNIYKTRISRRNSrhtwsaiYSLMFHLSIADVLVTwfCIIGEAAWCYTVQ---WLANELtCKL 200
Cdd:cd15331    6 ILGLLILATIIGNVFVIAAILLERSLQGVS-------NYLILSLAVADLMVA--VLVMPLSAVYEVSqhwFLGPEV-CDM 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 201 VKLFQMFSLYLSTYVLVLIGVDRWIAVK---YpMKSLNmAKRCHRLLGGTYILSLVLSLPQFFIF-HVARGPFVEEFYQC 276
Cdd:cd15331   76 WISMDVLCCTASILHLVAIALDRYWAVTnidY-IRRRT-AKRILIMIAVVWFVSLIISIAPLFGWkDEDDLDRVLKTGVC 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 277 VTHgfytadwQEQMYATFTLVFTFLLPLCILFGTYMSTFRTisssekmfqgsklanystAKlptqtnRQRlihkakmKSL 356
Cdd:cd15331  154 LIS-------QDYGYTIFSTVGAFYVPLLLMIIIYWKIYQA------------------AK------RER-------KAA 195
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 357 RISVVIIIAFLICWTPYYVMMIMfMFLNPDKRLGDDLQDAIFFFGMSNSLVNPLIYGAFH 416
Cdd:cd15331  196 RTLAIITGAFVVCWLPFFLVALV-MPFCGAWQISRFLESFFLWLGYFNSLLNPIIYTIFS 254
7tm_GPCRs cd14964
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
124-415 2.36e-12

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410628 [Multi-domain]  Cd Length: 267  Bit Score: 67.84  E-value: 2.36e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 124 VLAVMALFSLLGNLLTIWniyktriSRRNSRHTWSAIYSLMFHLSIADVLVTWFCIIGEAAWCYTVQWLANELTCKLVKL 203
Cdd:cd14964    4 ILSLLTCLGLLGNLLVLL-------SLVRLRKRPRSTRLLLASLAACDLLASLVVLVLFFLLGLTEASSRPQALCYLIYL 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 204 FQMFSLYLSTYVLVLIGVDRWIAVKYPMK--SLNMAKRCHRLLGGTYILSLVLSLPqffiFHVARGPFVEEFYQcvTHGF 281
Cdd:cd14964   77 LWYGANLASIWTTLVLTYHRYFALCGPLKytRLSSPGKTRVIILGCWGVSLLLSIP----PLVGKGAIPRYNTL--TGSC 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 282 YTADWQEQMYATFTLVFtFLLPLCILFgtymstfrtisssekmFQGSKLANYSTAKLPTQTNRQRLIHKAKMKSLRISVV 361
Cdd:cd14964  151 YLICTTIYLTWGFLLVS-FLLPLVAFL----------------VIFSRIVLRLRRRVRAIRSAASLNTDKNLKATKSLLI 213
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 442631927 362 IIIAFLICWTPYYVMMIMFMFLNPDKRLgDDLQDAIFFFGMSNSLVNPLIYGAF 415
Cdd:cd14964  214 LVITFLLCWLPFSIVFILHALVAAGQGL-NLLSILANLLAVLASTLNPFIYCLG 266
7tmA_NTSR-like cd14979
neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...
133-412 2.40e-12

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320110 [Multi-domain]  Cd Length: 300  Bit Score: 68.15  E-value: 2.40e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 133 LLGNLLTIwniykTRISRRNSRHTWSAIYslMFHLSIADVLVTWFCI---IGEAAWCYtvQWLANELTCKL-VKLFQMFS 208
Cdd:cd14979   15 IVGNLLTC-----IVIARHKSLRTTTNYY--LFSLAVSDLLILLVGLpveLYNFWWQY--PWAFGDGGCKLyYFLFEACT 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 209 lYLSTYVLVLIGVDRWIAVKYP--MKSLNMAKRCHRLLGGTYILSLVLSLPQFFIFHVA--RGPF---VEEFYQCVThgf 281
Cdd:cd14979   86 -YATVLTIVALSVERYVAICHPlkAKTLVTKRRVKRFILAIWLVSILCAIPILFLMGIQylNGPLpgpVPDSAVCTL--- 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 282 YTADWQEQMYATFTLVFTFLLPLCILFGTYM---STFRTISSSEKMFQGSKLANystaklptqtNRQRLIHKAKMKSLRI 358
Cdd:cd14979  162 VVDRSTFKYVFQVSTFIFFVLPMFVISILYFrigVKLRSMRNIKKGTRAQGTRN----------VELSLSQQARRQVVKM 231
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 442631927 359 SVVIIIAFLICWTPYYVMMIMFMFL-NPDKRLGDDLQD----AIFFFGMSnSLVNPLIY 412
Cdd:cd14979  232 LGAVVIAFFVCWLPFHAQRLMFSYAsKEDTFLFDFYQYlypiSGILFYLS-SAINPILY 289
7tmA_NMBR cd15125
neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
119-410 2.47e-12

neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin B receptor (NMBR), also known as BB1, is a G-protein coupled receptor whose endogenous ligand is the neuropeptide neuromedin B. Neuromedin B is a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. NMBR is widely distributed in the CNS, with especially high levels in olfactory nucleus and thalamic regions. The receptor couples primarily to a pertussis-toxin-insensitive G protein of the Gq/11 family, which leads to the activation of phospholipase C. NMBR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include gastrin-releasing peptide receptor (GRPR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320253 [Multi-domain]  Cd Length: 292  Bit Score: 68.05  E-value: 2.47e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 119 LLKVYVLAVMAlfSLLGNLlTIWNIYKTRISRRnsrhtwSAIYSLMFHLSIADVLVTWFCIIGEAAWCYTVQWLANELTC 198
Cdd:cd15125    3 IPSLYLLIITV--GLLGNI-TLVKIFITNSAMR------SVPNIFISSLAAGDLLLLVTCVPVDASRYFYEEWMFGTVGC 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 199 KLVKLFQMFSLYLSTYVLVLIGVDRWIAVKYPM---KSLNMAKRCHRLLgGTYILSLVLSLPQFFIFHVAR--GPFVEEF 273
Cdd:cd15125   74 KLIPVIQLTSVGVSVFTLTALSADRYKAIVNPMdiqTSSAVLRTCLKAI-AIWVVSVLLAVPEAVFSEVAHimPDDNTTF 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 274 YQCVTHGFyTADWQEQMYATFTLVFTFLLPLCILFGTYMSTFRTISSSEKMFQGsKLANYSTAKLPTqtnRQRLIhkakm 353
Cdd:cd15125  153 TACIPYPQ-TDEMHPKIHSVLIFLVYFLIPLAIISIYYYHIAKTLIKSAHNIPG-EYSEHSKRQMET---RKRLA----- 222
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 354 kslRISVVIIIAFLICWTPYYV--MMIMFMFLNPDKRLGDDLQDAIF-FFGMSNSLVNPL 410
Cdd:cd15125  223 ---KIVLVFVGLFAFCWFPNHVlyMYRSFNYNEIDSSLGHMIVTLVArVLSFCNSCVNPF 279
7tmA_Kappa_opioid_R cd15091
opioid receptor subtype kappa, member of the class A family of seven-transmembrane G ...
124-412 2.70e-12

opioid receptor subtype kappa, member of the class A family of seven-transmembrane G protein-coupled receptors; The kappa-opioid receptor binds the opioid peptide dynorphin as the primary endogenous ligand. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320219 [Multi-domain]  Cd Length: 282  Bit Score: 67.67  E-value: 2.70e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 124 VLAVMALFSLLGNLLTIWNIYktrisRRNSRHTWSAIYslMFHLSIADVLVTWFCIIGEAAWCYTvQWLANELTCKLVKL 203
Cdd:cd15091    6 VYSVVFVVGLVGNSLVMFVII-----RYTKMKTATNIY--IFNLALADALVTTTMPFQSTVYLMN-SWPFGDVLCKIVIS 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 204 FQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLN----MAKRCHRLLggTYILSLVLSLPQFfifhVARGPFVEE---FYQC 276
Cdd:cd15091   78 IDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDfrtpLKAKIINIC--IWLLSSSVGISAI----VLGGTKVREdvdSTEC 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 277 VTHgFYTAD--WQEQMYATFTLVFTFLLPLCILFGTYMSTFRTISSSeKMFQGSKlanystaklPTQTNRQRLIhkakmk 354
Cdd:cd15091  152 SLQ-FPDDDysWWDTFMKICVFIFAFVIPVLIIIVCYTLMILRLKSV-RLLSGSR---------EKDRNLRRIT------ 214
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 442631927 355 slRISVVIIIAFLICWTPYYVMMIMfmflnpdKRLGDDLQD----AIFFF----GMSNSLVNPLIY 412
Cdd:cd15091  215 --RLVLVVVAVFVVCWTPIHIFILV-------EALGSVSHStaavSSYYFcialGYTNSSLNPILY 271
7tmA_Ap5-HTB1-like cd15065
serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...
124-415 2.92e-12

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.


Pssm-ID: 320193 [Multi-domain]  Cd Length: 300  Bit Score: 67.76  E-value: 2.92e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 124 VLAVMALFSLLGNLLTIWNIYKTRISRRNSrhtwsaiYSLMFHLSIADVLVTwfCIIGEAAWCYTVQ--WLANELTCKLV 201
Cdd:cd15065    5 FLSLIIVLAIFGNVLVCLAIFTDRRLRKKS-------NLFIVSLAVADLLVA--LLVMTFAVVNDLLgyWLFGETFCNIW 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 202 KLFQ-MFSLyLSTYVLVLIGVDRWIAVKYPMK-SLNMAKRCHRLLGGT-YILSLVLS-LPQFFIFHVARGPFVEEFYQCV 277
Cdd:cd15065   76 ISFDvMCST-ASILNLCAISLDRYIHIKKPLKyERWMTTRRALVVIASvWILSALISfLPIHLGWHRLSQDEIKGLNHAS 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 278 THGFYTADWQEQMYATFTLVFTFLLPLCILFGTYMSTFRTISSSEKMFQGSKLANYSTAK---LPTQTNRQRLI---HKA 351
Cdd:cd15065  155 NPKPSCALDLNPTYAVVSSLISFYIPCLVMLLIYSRLYLYARKHVVNIKSQKLPSESGSKfqvPSLSSKHNNQGvsdHKA 234
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 442631927 352 kmkslRISVVIIIA-FLICWTPYYVMMIMFMFLnpDKRLGDDLQDAIFFFGMSNSLVNPLIYGAF 415
Cdd:cd15065  235 -----AVTLGIIMGvFLICWLPFFIINIIAAFC--KTCIPPKCFKILTWLGYFNSCLNPIIYSIF 292
7tmA_SREB-like cd15005
super conserved receptor expressed in brain and related proteins, member of the class A family ...
120-385 3.03e-12

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320134 [Multi-domain]  Cd Length: 329  Bit Score: 68.25  E-value: 3.03e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 120 LKVYVLAVMALFSLLGNLLTIWNIYKTRISRRnsrhtwsAIYSLMFHLSIADVLVTWFCI-IGEAAWCYTVQWLANELTC 198
Cdd:cd15005    2 LKLTTLGLILCVSLAGNLLFSVLIVRDRSLHR-------APYYFLLDLCLADGLRSLACFpFVMASVRHGSGWIYGALSC 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 199 KLVKLFQMFSLYLSTYVLVLIGVDRWIAVKYP-MKSLNMAK-RCHRLLGGTYILSLVLSLPQffIFHVARGPFVEEFYQC 276
Cdd:cd15005   75 KVIAFLAVLFCFHSAFTLFCIAVTRYMAIAHHrFYAKRMTFwTCLAVICMAWTLSVAMAFPP--VFDVGTYTFIREEDQC 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 277 V-THGFYTADwqeqmyatFTLVFTFLLPLcILFGT---YMSTFRTISSSEKM-------------------FQGSKLANY 333
Cdd:cd15005  153 TfEHRSYKAN--------DTLGFMLVLAV-VIAAThlvYLKLLIFLRHHRKMkpaqlvpaisqnwtfhgpgATGQAAANW 223
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 442631927 334 STAKL-----PTQ--------TNRQRLI----HKAKMKSLRISVVIIIAFLICWTPYYVMMIMFMFLNP 385
Cdd:cd15005  224 TAGFGrgptpPTLlgirqafhSGARRLLvldeFKMEKRLTRMFYAITLLFLLLWSPYIVACYIRVFVRG 292
7tmA_alpha1D_AR cd15327
alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
124-412 3.95e-12

alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320450 [Multi-domain]  Cd Length: 261  Bit Score: 66.86  E-value: 3.95e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 124 VLAVMALFSLLGNLLTIwniyktrISRRNSRHTWSAIYSLMFHLSIADVLVTWFCIIGEAAWCYTVQWLANELTCKLVKL 203
Cdd:cd15327    6 FLAIFILMAIVGNILVI-------LSVACNRHLQTVTNYFIVNLAIADLLLSTTVLPFSATLEVLGFWAFGRVFCDIWAA 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 204 FQMFSLYLSTYVLVLIGVDRWIAVKYPMK--SLNMAKRCHRLLGGTYILSLVLSLPQFFIFHVARGPfvEEFYQCVThgf 281
Cdd:cd15327   79 VDVLCCTASILSLCVISVDRYVGVKHSLKypTIMTERKAGVILVLLWVSSMVISIGPLLGWKEPPPP--DESICSIT--- 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 282 ytadwQEQMYATFTLVFTFLLPLCILFGTYmstFRTISSSEKMFQGSKLAnystaklptqtnrqrlihkakmKSLRISVV 361
Cdd:cd15327  154 -----EEPGYALFSSLFSFYLPLMVILVMY---FRVYVVALKFSREKKAA----------------------KTLAIVVG 203
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 442631927 362 IiiaFLICWTPYYVMMIMFMFLnPDKRLGDDLQDAIFFFGMSNSLVNPLIY 412
Cdd:cd15327  204 V---FILCWFPFFFVLPLGSFF-PALKPSEMVFKVIFWLGYFNSCVNPIIY 250
7tmA_Peropsin cd15073
retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of ...
125-412 4.04e-12

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors; Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.


Pssm-ID: 320201 [Multi-domain]  Cd Length: 280  Bit Score: 67.07  E-value: 4.04e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 125 LAVMALFSLLGNLLTIWNIYKTRISRrnsrhtwSAIYSLMFHLSIADVLVTWFCIIGEAAWCYTVQWLANELTCKLVKLF 204
Cdd:cd15073    7 LIVAGIISTISNGIVLVTFVKFRELR-------TPTNALIINLAVTDLGVSIIGYPFSAASDLHGSWKFGYAGCQWYAFL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 205 QMFSLYLSTYVLVLIGVDRWIAVKYPMKSLNMAKRchrllggTY-ILSLVLSLPQFFIfhvARGPFV--EEFYQCVTHGF 281
Cdd:cd15073   80 NIFFGMASIGLLTVVAVDRYLTICRPDLGRKMTTN-------TYtVMILLAWTNAFFW---AAMPLVgwASYALDPTGAT 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 282 YTADWQ--EQMYATFTL---VFTFLLPLCILFGTYMSTFRTISSsekmfqgsklanYSTAKLPTQTNR--QRLIHKAKMk 354
Cdd:cd15073  150 CTINWRknDSSFVSYTMsviVVNFIVPLAVMFYCYYNVSRFVKK------------VLASDCLESVNIdwTDQNDVTKM- 216
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 442631927 355 slriSVVIIIAFLICWTPYYVMMIMFMFLNPdKRLGDDLQDAIFFFGMSNSLVNPLIY 412
Cdd:cd15073  217 ----SVIMIVMFLVAWSPYSIVCLWASFGEP-KKIPPWMAIIPPLFAKSSTFYNPCIY 269
7tmA_P2Y6_P2Y3-like cd15968
P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of ...
130-412 6.25e-12

P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes P2Y receptor 6 (P2Y6), P2Y3, and P2Y3-like proteins. These receptors belong to the G(i) class of a family of purinergic G-protein coupled receptors. In the CNS, P2Y6 plays a role in microglia activation and phagocytosis, and is involved in the secretion of interleukin from monocytes and macrophages in the immune system. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320634 [Multi-domain]  Cd Length: 285  Bit Score: 66.72  E-value: 6.25e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 130 LFSLLGNLLTIWniyktRISRRNSRHTWSAIYslMFHLSIADVLVTWFCIIGEAAWCYTVQWLANELTCKLVKLFQMFSL 209
Cdd:cd15968   12 LLGLPLNSVVLT-----RCCRHTKAWTRTAIY--MVNLALADLLYALSLPLLIYNYAMRDRWLFGDFMCRLVRFLFYFNL 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 210 YLSTYVLVLIGVDRWIAVKYPMKSlnMAKRCHRLLGGTYILSLVLSLPQFF-IFHVARGPFVEEFYQCVTHGFYTADWQE 288
Cdd:cd15968   85 YGSILFLTCISVHRYLGICHPMRP--WHKETRRAAWLTCVLVWILVFAQTLpILIFARTGIIRNRTVCYDLAPPALFPHY 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 289 QMYATFTLVFTFLLPLCILFGTYMSTFRTISSSEKmfqgsklanysTAKLPTQTNRQrlihkakmKSLRISVVIIIAFLI 368
Cdd:cd15968  163 VPYGMALTVSGFLLPFSIILWCYCLVVRTLCRTLG-----------PAEPPAQARRR--------KSIRTIVTVTLLFAL 223
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 442631927 369 CWTPYYVMMIMFMFLNPDKRLGDDLQDAIFF-------FGMSNSLVNPLIY 412
Cdd:cd15968  224 CFLPFHITRTIYLAVRVTPGVPCHVLEAVAAcykitrpLASANSVLNPLLY 274
7tmA_CXCR6 cd15173
CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G ...
126-381 6.81e-12

CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR6 binds specifically to the chemokine CXCL16, which is expressed on dendritic cells, monocyte/macrophages, activated T cells, fibroblastic reticular cells, and cancer cells. CXCR6 is phylogenetically more closely related to CC-type chemokine receptors (CCR6 and CCR9) than other CXC receptors. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320301 [Multi-domain]  Cd Length: 270  Bit Score: 66.33  E-value: 6.81e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 126 AVMALFSLLGNLLTIWnIYKTRISRRnsrhTWSAIYslMFHLSIADVLvtWFCIIGEAAWCYTVQWLANELTCKLVKLFQ 205
Cdd:cd15173    8 SVMFVTGLVGNSLVIV-IYIFYEKLR----TLTDIF--LVNLAVADLL--FLCTLPFWAYSAAHEWIFGTVMCKITNGLY 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 206 MFSLYLSTYVLVLIGVDRWIAVKYPMKSLNM-AKR--CHRLLG-GTYILSLVLSLPQfFIFHVARgpfveEFYQCVTHGF 281
Cdd:cd15173   79 TINLYSSMLILTCITVDRFIVIVQATKAHNChAKKmrWGKVVCtLVWVISLLLSLPQ-FIYSEVR-----NLSSKICSMV 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 282 YTADWQEQMYATFTLVFTFLLPLCILFGTYMSTFRTISSSeKMFQgsklanystaklptqtnrqrlihkaKMKSLRISVV 361
Cdd:cd15173  153 YPPDAIEVVVNIIQMTVGFFLPLLAMIICYSVIIKTLLHA-KGFQ-------------------------KHKSLKIIFV 206
                        250       260
                 ....*....|....*....|
gi 442631927 362 IIIAFLICWTPYYVMMIMFM 381
Cdd:cd15173  207 VVAVFILTQLPYNIMKLIRT 226
7tmA_alpha1B_AR cd15326
alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
123-412 7.18e-12

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320449 [Multi-domain]  Cd Length: 261  Bit Score: 66.07  E-value: 7.18e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 123 YVLAVMALFSLLGNLLTIwniyktrISRRNSRHTWSAIYSLMFHLSIADVLVTWFCIIGEAAWCYTVQWLANELTCKLVK 202
Cdd:cd15326    5 LVLGAFILFAIVGNILVI-------LSVVCNRHLRIPTNYFIVNLAIADLLLSFTVLPFSATLEILGYWVFGRIFCDIWA 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 203 LFQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLNMAKRCHRLLG--GTYILSLVLSLPQFFIFhvaRGPFVEEFYQC-VTh 279
Cdd:cd15326   78 AVDVLCCTASILSLCAISIDRYIGVRHSLQYPTIVTRKRAILAllGVWVLSTVISIGPLLGW---KEPAPPDDKVCeIT- 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 280 gfytadwQEQMYATFTLVFTFLLPLCILFGTYMSTFRTisssekMFQGSKlanystaklptqtnrqrliHKAKMKSLRIS 359
Cdd:cd15326  154 -------EEPFYALFSSLGSFYIPLIVILVMYCRVYIV------ALKFSR-------------------EKKAAKTLGIV 201
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 442631927 360 VVIiiaFLICWTPYYVMM---IMFMFLNPDkrlgDDLQDAIFFFGMSNSLVNPLIY 412
Cdd:cd15326  202 VGM---FILCWLPFFIALplgSLFSHLKPP----ETLFKIIFWLGYFNSCLNPIIY 250
7tmA_D1A_dopamine_R cd15320
D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
125-412 7.61e-12

D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320443 [Multi-domain]  Cd Length: 319  Bit Score: 66.95  E-value: 7.61e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 125 LAVMALFSLLGNLLTIWNIYKTRISRrnSRHTWSAIYSLMFHLSIADVLVTWFCIIGEAA--W---CYTVQWLANELTCK 199
Cdd:cd15320    8 LSVLILSTLLGNTLVCAAVIRFRHLR--SKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAgfWpfgSFCNIWVAFDIMCS 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 200 LVKLFQmfslylstyvLVLIGVDRWIAVKYPMK-SLNMAKR-CHRLLGGTYILSLVLS-LPQFFIFHVARGPFVEEFyQC 276
Cdd:cd15320   86 TASILN----------LCVISVDRYWAISSPFRyERKMTPKvAFIMISVAWTLSVLISfIPVQLNWHKAKPTSFLDL-NA 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 277 VTHGFYTADWQE---QMYATFTLVFTFLLPLCILFGTYMSTFRT-------ISSSEKMFQGSKLANYSTAKLPTQTNRQ- 345
Cdd:cd15320  155 SLRDLTMDNCDSslnRTYAISSSLISFYIPVAIMIVTYTRIYRIaqkqirrISALERAAVHAKNCQNSTGNRGSGDCQQp 234
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 442631927 346 ----RLIHKAKMKSLRISVVIIIAFLICWTPYYVMMIMFMFLNPDKR----LGDDLQDAIFFFGMSNSLVNPLIY 412
Cdd:cd15320  235 essfKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCKPTSTepfcISSTTFDVFVWFGWANSSLNPIIY 309
7tmA_Dop1R2-like cd15067
dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...
124-412 1.19e-11

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.


Pssm-ID: 320195 [Multi-domain]  Cd Length: 262  Bit Score: 65.46  E-value: 1.19e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 124 VLAVMALFSLLGNLLTIWNIYKTRISRRNSRHtwsaiysLMFHLSIADVL----VTWFCIIGEAAWCYtvqWLANELTCK 199
Cdd:cd15067    5 VLSLFCLVTVAGNLLVILAVLRERYLRTVTNY-------FIVSLAVADLLvgsiVMPFSILHEMTGGY---WLFGRDWCD 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 200 LVKLFQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLNM--AKRCHRLLGGTYILSLVLSLPQfFIFHVARGPFVEEFYQCV 277
Cdd:cd15067   75 VWHSFDVLASTASILNLCVISLDRYWAITDPISYPSRmtKRRALIMIALVWICSALISFPA-IAWWRAVDPGPSPPNQCL 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 278 thgfYTADwqeQMYATFTLVFTFLLPLCILFGTYMSTFRtISSSEkmfqgsklanystaklptqtnrqrliHKAKmKSLR 357
Cdd:cd15067  154 ----FTDD---SGYLIFSSCVSFYIPLVVMLFTYYRIYR-AAAKE--------------------------QKAA-KTLG 198
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 442631927 358 IsvvIIIAFLICWTPYYVMMIMFMFLNPDKRLGDDLQDAIF-FFGMSNSLVNPLIY 412
Cdd:cd15067  199 I---VMGVFILCWLPFFVTNILIGFCPSNCVSNPDILFPLVtWLGYINSGMNPIIY 251
7tmA_GHSR-like cd15928
growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the ...
124-412 1.27e-11

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes growth hormone secretagogue receptor (GHSR or ghrelin receptor), motilin receptor (also called GPR38), and related proteins. Both GHSR and GPR38 bind peptide hormones. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin is also called the hunger hormone and is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. Motilin, the ligand for GPR38, is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. It is involved in the regulation of digestive tract motility.


Pssm-ID: 320594 [Multi-domain]  Cd Length: 288  Bit Score: 65.97  E-value: 1.27e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 124 VLAVMALFSLLGNLLTIWNIYKTRISRrnsrhtwSAIYSLMFHLSIADVLvTWFCIIGE--AAWCYTvQWLANELTCKLV 201
Cdd:cd15928    6 VCSVLMLVGASGNLLTVLVIGRSRDMR-------TTTNLYLSSLAVSDLL-IFLVLPLDlyRLWRYR-PWRFGDLLCRLM 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 202 KLFQMFSLYLSTYVLVLIGVDRWIAVKYPM--KSLNMAKRCHRLLGGTYILSLVLSLPQFFIFHVARGPFVEEFYQC--- 276
Cdd:cd15928   77 YFFSETCTYASILHITALSVERYLAICHPLraKVLVTRGRVKLLIAVIWAVAIVSAGPALVLVGVEHIQGQQTPRGFect 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 277 ---VTHGFYTA-DWQEQMYatftlvftFLLPLCILFGTYMSTFRTISSSekmfqgSKLANYSTAKLPTQTNRQrlihkak 352
Cdd:cd15928  157 vvnVSSGLLSVmLWVSTSF--------FFVPMVCLSLLYGLIGRALWDR------RQRSRTAGASRRDNNHRQ------- 215
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 442631927 353 mkSLRISVVIIIAFLICWTPYYVMMIMFMF-LNPDKRLGDDLQD----AIFFFGMSNSlVNPLIY 412
Cdd:cd15928  216 --TVRMLAVIVLAFVLCWLPFHVGRVIFNHsRASTKHLHYVSQYfnlvSFVLFYLSAA-INPILY 277
7tmA_GPR25 cd15193
G protein-coupled receptor 25, member of the class A family of seven-transmembrane G ...
126-412 1.37e-11

G protein-coupled receptor 25, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR25 is an orphan G-protein coupled receptor that shares strong sequence homology to GPR15 and the angiotensin II receptors. These closely related receptors form a group within the class A G-protein coupled receptors (GPCRs). GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation. Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors.


Pssm-ID: 320321 [Multi-domain]  Cd Length: 279  Bit Score: 65.54  E-value: 1.37e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 126 AVMALFSLLGNLLTIWNIYKTRISRRnsrhtwsAIYSLMFHLSIADVLVTWFCIIGEAAWCYTVQWLANELTCKLVKLFQ 205
Cdd:cd15193    8 LIIFFTGLLGNLFVIALMSKRSTTKR-------LVDTFVLNLAVADLVFVLTLPFWAASTALGGQWLFGEGLCKLSSFII 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 206 MFSLYLSTYVLVLIGVDRWIAVKYPMKSLNMAKRCHRLL--GGTYILSLVLSLPQFFIFHVARGPF-VEEFYQCVTHGFY 282
Cdd:cd15193   81 AVNRCSSILFLTGMSVDRYLAVVKLLDSRPLRTRRCALItcCIIWAVSLVLGIPSLVYRNLINESVcVEDSSSRFFQGIS 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 283 TAdwqeqmyatfTLVFTFLLPLCILFGTYMSTFRTIsssekmfqgsklanYSTAKLPTQTNRQRlihkakMKSLRISVVI 362
Cdd:cd15193  161 LA----------TLFLTFVLPLIVILFCYCSILVRL--------------RRHFHGAKRTGRRR------RNSLRIVFAI 210
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 442631927 363 IIAFLICWTPYYVMMIMFMFLN-PDKRLGDDLQDAIFF-------FGMSNSLVNPLIY 412
Cdd:cd15193  211 VTAFVLSWLPFNTLKAVRLLLElGGGVLPCHTTVAIRQgltitacLAFVNSCVNPLIY 268
7tmA_TAAR5-like cd15317
trace amine-associated receptor 5 and similar receptors, member of the class A family of ...
124-416 1.46e-11

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320440 [Multi-domain]  Cd Length: 290  Bit Score: 65.55  E-value: 1.46e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 124 VLAVMALFSLLGNLLTIWNIyktriSRRNSRHTWSAIysLMFHLSIADVL----VTWFCIIGEAAWCytvqWLANELTCK 199
Cdd:cd15317    6 VLVLAMLITVSGNLVVIISI-----SHFKQLHSPTNM--LVLSLATADFLlglcVMPFSMIRTVETC----WYFGDLFCK 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 200 LVKLFQMFSLYLSTYVLVLIGVDRWIAV----KYPMK-SLNMAKRC---HRLLGGTYILSlvlslpqFFIFHVARG---P 268
Cdd:cd15317   75 FHTGLDLLLCTTSIFHLCFIAIDRYYAVcdplRYPSKiTVQVAWRFiaiGWLVPGIYTFG-------LIYTGANDEgleE 147
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 269 FVEEFY---QCVThgFYTADWqeqmyaTFTLVFTFLLPLCILFGTYMSTF-------RTISSSEKMFQgSKLANYSTAKl 338
Cdd:cd15317  148 YSSEIScvgGCQL--LFNKIW------VLLDFLTFFIPCLIMIGLYAKIFlvarrqaRKIQNMEDKFR-SSEENSSKAS- 217
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 442631927 339 ptqtnrQRLIHKAkMKSLRISVVIiiaFLICWTPYYVMMIMFMFLNPDKrlGDDLQDAIFFFGMSNSLVNPLIYGAFH 416
Cdd:cd15317  218 ------ASRERKA-AKTLAIVMGI---FLFCWLPYFIDTIVDEYSNFIT--PAIVFDAVIWLGYFNSAFNPFIYAFFY 283
7tmA_Beta_AR cd15058
beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...
117-412 1.49e-11

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320186 [Multi-domain]  Cd Length: 305  Bit Score: 65.94  E-value: 1.49e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 117 SGLLKVYVLAVMALfsLLGNLLTIWNIYKTRisrrnSRHTWSAIYslMFHLSIADVLVTWFCIIGEAAWCYTVQWLANEL 196
Cdd:cd15058    1 PGLLLLLALIILAI--VVGNLLVIIAIARTS-----RLQTMTNIF--ITSLACADLVMGLLVVPLGATIVVTGKWQLGNF 71
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 197 TCKLVKLFQMFSLYLSTYVLVLIGVDRWIAVKYPM--KSLnMAKRCHRLLGGT-YILS-LVLSLPQFFIFHVARGPFVEE 272
Cdd:cd15058   72 WCELWTSVDVLCVTASIETLCVIAVDRYIAITRPLryQVL-LTKRRARVIVCVvWIVSaLVSFVPIMNQWWRANDPEAND 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 273 FYQ---CVThgFYTadwqEQMYATFTLVFTFLLPLCILFGTYMSTF-------RTISSSEKMFQGSKLAN---YSTAKLP 339
Cdd:cd15058  151 CYQdptCCD--FRT----NMAYAIASSVVSFYIPLLIMIFVYARVFliatrqlQLIDKRRLRFQSECPAPqttSPEGKRS 224
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 442631927 340 TQTNRQRLIHKAKMKSLRISVVIIIAFLICWTPYYVMMIMFMFlNPDkRLGDDLQDAIFFFGMSNSLVNPLIY 412
Cdd:cd15058  225 SGRRPSRLTVVKEHKALKTLGIIMGTFTLCWLPFFIANIINVF-NRN-LPPGEVFLLLNWLGYINSGLNPIIY 295
7tmA_PAR cd15162
protease-activated receptors, member of the class A family of seven-transmembrane G ...
124-412 1.99e-11

protease-activated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes purinergic receptor P2Y8 and protease-activated receptors. P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PAR3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341328 [Multi-domain]  Cd Length: 280  Bit Score: 65.16  E-value: 1.99e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 124 VLAVMALFSLLGNLLTIWnIYKTRISRRnsrhTWSAIYslMFHLSIADVLvtwFCIIGEAAWCYTVQ---WLANELTCKL 200
Cdd:cd15162    6 VYTLVFVVGLPANGMALW-VLLFRTKKK----APAVIY--MANLAIADLL---LVIWLPFKIAYHIHgnnWIFGEALCRL 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 201 VKLFQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLnmAKRCHRLLGGTYILSLVLSLPQFFIFHVARGPFVEEFYQCVT-H 279
Cdd:cd15162   76 VTVAFYGNMYCSILLLTCISIDRYLAIVHPMGHR--RLRARRYALGTCLAIWLLALLVTLPLYLVKQTIFLPALDITTcH 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 280 GFYTADWQEQMYATFTL---VFTFLLPLCILFGTYMSTFRTISSSEKMFQGSKlanystaklptqtnrqrlihkaKMKSL 356
Cdd:cd15162  154 DVLPEQLLVGDWFYYFLslaIVGFLIPFILTASCYVATIRTLAALEDENSEKK----------------------KKRAI 211
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 442631927 357 RISVVIIIAFLICWTPYYVMMIMFMFLnpdkrLGDDLQDAIFF-------FGMSNSLVNPLIY 412
Cdd:cd15162  212 KLAATVLAIFIICFAPSNLLLLAHYSL-----ISSSGTGHLYFayllalcLSTLNSCIDPFIY 269
7tmA_Relaxin_R cd15137
relaxin family peptide receptors, member of the class A family of seven-transmembrane G ...
127-412 2.15e-11

relaxin family peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes relaxin/insulin-like family peptide receptor 1 (RXFP1 or LGR7) and 2 (RXFP2 or LGR8), which contain a very large extracellular N-terminal domain with numerous leucine-rich repeats responsible for hormone recognition and binding. Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four GPCRs, RXFP1-4. Relaxin and INSL3 are the endogenous ligands for RXFP1 and RXFP2, respectively. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP.


Pssm-ID: 320265 [Multi-domain]  Cd Length: 284  Bit Score: 64.91  E-value: 2.15e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 127 VMALFSLLGNLLTIWniYKTRISRRNSRHTwsaiyslMF--HLSIADVLVTWFCII---------GEAAWcYTVQWLaNE 195
Cdd:cd15137    9 VVGIIALLGNLFVLI--WRLKYKEENKVHS-------FLikNLAIADFLMGVYLLIiasvdlyyrGVYIK-HDEEWR-SS 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 196 LTCKLVKLFQMFSLYLSTYVLVLIGVDRWIAVKYPMKS--LNMaKRCHRLLGGTYILSLVLSLpqffiFHVARGPFVEEF 273
Cdd:cd15137   78 WLCTFAGFLATLSSEVSVLILTLITLDRFICIVFPFSGrrLGL-RRAIIVLACIWLIGLLLAV-----LPLLPWDYFGNF 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 274 YQ----CVT---HGFYTADWQeqmYATFTLVFTFLLPLCILFGTYMSTFRTISssekmfqgsklanySTAKLPTQTNRQR 346
Cdd:cd15137  152 YGrsgvCLPlhiTDERPAGWE---YSVFVFLGLNFLAFVFILLSYIAMFISIR--------------RTRKAAASRKSKR 214
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 442631927 347 LIHKAKmkslRISVVIIIAFLiCWTPYYVMMIMFMFLNPdkrLGDDLQD--AIFFFGMsNSLVNPLIY 412
Cdd:cd15137  215 DMAVAK----RFFLIVLTDFL-CWIPIIVIGILALSGVP---IPGEVYAwvAVFVLPI-NSALNPILY 273
7tmA_NPY1R cd15395
neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G ...
130-413 2.72e-11

neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320517 [Multi-domain]  Cd Length: 293  Bit Score: 64.84  E-value: 2.72e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 130 LFSLLGNLLTIwniykTRISRRNSRHTWSAIysLMFHLSIADVLVTWFCIIGEAAWCYTVQWLANELTCKLVKLFQMFSL 209
Cdd:cd15395   12 ILGVSGNLALI-----IIILKQKEMHNVTNI--LIVNLSFSDLLMTIMCLPFTFVYTLMDHWVFGEAMCKLNSMVQCISI 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 210 YLSTYVLVLIGVDRWIAVKYPMKSLNMAKRCHRLLGGTYILSLVLSLPqFFIFHV-ARGPF------VEEF---YQCVTH 279
Cdd:cd15395   85 TVSIFSLVLIAIERHQLIINPRGWRPNNRHAYVGIAVIWVLAVLTSLP-FLIFQVlTDEPFknvnvsLDAYkgkYVCLDQ 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 280 gfYTADWQEQMYATFTLVFTFLLPLCILFGTYMSTFRTISSSEKMFQGSKLANYSTAklptqtnrqrlihkakmKSLRIS 359
Cdd:cd15395  164 --FPSDTIRLSYTTCLLVLQYFGPLCFIFICYLKIYIRLKRRNNMMDKMRDNKYRSS-----------------ETKRIN 224
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 442631927 360 VV---IIIAFLICWTPYYVMMIMF-----MFLNPDKRLgddLQDAIFFFGMSNSLVNPLIYG 413
Cdd:cd15395  225 IMlisIVVAFAVCWLPLNIFNAVFdwnheAIATCNHNL---LFLICHLTAMISTCVNPIFYG 283
7tmA_tyramine_octopamine_R-like cd15060
tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G ...
119-417 3.55e-11

tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine/octopamine receptors and similar proteins found in insects and other invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320188 [Multi-domain]  Cd Length: 260  Bit Score: 63.99  E-value: 3.55e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 119 LLKVYVLAVMALFSLLGNLLTIWNIYKTRISRrnsrhtwsaIYSLMF--HLSIADVLVTWFCIIGEAAWCYTVQWLANEL 196
Cdd:cd15060    1 VVTTILLSVIIAFTIVGNILVILSVFTYRPLR---------IVQNFFivSLAVADLAVAIFVLPLNVAYFLLGKWLFGIH 71
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 197 TCKLVKLFQMFSLYLSTYVLVLIGVDRWIAVKYPmksLNMA-----KRCHRLLGGTYILSLVLSLPQFFIFHVARGPFVE 271
Cdd:cd15060   72 LCQMWLTCDILCCTASILNLCAIALDRYWAIHDP---INYAqkrtlKRVLLMIVVVWALSALISVPPLIGWNDWPENFTE 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 272 EFYQCVThgfytadwQEQMYATFTLVFTFLLPLCILFGTYMSTFRTISSsEKmfqgsklanystaklptqtnrqrlihka 351
Cdd:cd15060  149 TTPCTLT--------EEKGYVIYSSSGSFFIPLLIMTIVYVKIFIATSK-ER---------------------------- 191
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 442631927 352 kmKSLRISVVIIIAFLICWTPYYVMMIMFMF---LNPDKRlgddLQDAIFFFGMSNSLVNPLIYGAFHL 417
Cdd:cd15060  192 --RAARTLGIIMGVFVVCWLPFFLMYVILPFcetCSPSAK----VVNFITWLGYVNSALNPVIYTIFNL 254
7tmA_Beta3_AR cd15959
beta-3 adrenergic receptors (adrenoceptors), member of the class A family of ...
124-412 3.77e-11

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-3 adrenergic receptor (beta-3 adrenoceptor), also known as beta-3 AR, is activated by adrenaline and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320625 [Multi-domain]  Cd Length: 302  Bit Score: 64.54  E-value: 3.77e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 124 VLAVMALFSLLGNLLTIWNIYKT-RIsrrnsrHTWSAIYslMFHLSIADVLVTWFCIIGEAAWCYTVQWLANELTCKLVK 202
Cdd:cd15959    6 LLSLAILVIVGGNLLVIVAIAKTpRL------QTMTNVF--VTSLACADLVMGLLVVPPGATILLTGHWPLGTTVCELWT 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 203 LFQMFSLYLSTYVLVLIGVDRWIAVKYPMK-SLNMAKRCHRLlggtyILSLVLSLPQFFIF-----HVARGPFVEEFYQC 276
Cdd:cd15959   78 SVDVLCVTASIETLCAIAVDRYLAITNPLRyEALVTKRRART-----AVCLVWAISAAISFlpimnQWWRDGADEEAQRC 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 277 VTHGFYTADWQEQMYATFTLVFTFLLPLCILFGTYMSTFRTISSSEKMFQGSKlANYSTAKLPTQTNR-------QRLIH 349
Cdd:cd15959  153 YDNPRCCDFVTNMPYAIVSSTVSFYVPLLVMIFVYVRVFVVATRQVRLIRKDK-VRFPPEESPPAESRpacgrrpSRLLA 231
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 442631927 350 KAKMKSLRISVVIIIAFLICWTPYYVMMIMFMFLNPdkRLGDDLQDAIFFFGMSNSLVNPLIY 412
Cdd:cd15959  232 IKEHKALKTLGIIMGTFTLCWLPFFVANIIKVFCRS--LVPDPAFLFLNWLGYANSAFNPIIY 292
7tmA_Prostanoid_R cd14981
G protein-coupled receptors for prostanoids, member of the class A family of ...
126-412 3.94e-11

G protein-coupled receptors for prostanoids, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320112 [Multi-domain]  Cd Length: 288  Bit Score: 64.19  E-value: 3.94e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 126 AVMALFSLLGNLLTIWNIYKTRisrrnSRHTWSAIYSLMFHLSIADVLVTWFCI-IGEAAWCYTVQWLANELTCKLVKLF 204
Cdd:cd14981    8 ALMFVFGVLGNLLALIVLARSS-----KSHKWSVFYRLVAGLAITDLLGILLTSpVVLAVYASNFEWDGGQPLCDYFGFM 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 205 QMFSLYLSTYVLVLIGVDRWIAVKYP-MKSLNMAKRCHRL-LGGTYILSLVLSLpqffiFHVARGPFVEEFYQCvTHGFY 282
Cdd:cd14981   83 MSFFGLSSLLIVCAMAVERFLAITHPfFYNSHVKKRRARLmLGAVWAFALLIAS-----LPLLGLGSYVLQYPG-TWCFL 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 283 TADWQEQMYATFTLVFTFLLPLCILfGTYMSTFRTISSSEKMFQGSKlanystaKLPTQTNRQRLIHKAKMKSLRISVVI 362
Cdd:cd14981  157 DFYSKNTGDAAYAYLYSILGLLILL-VTLLCNLLVIITLLRMRRRKK-------RHRRSRRSARRQKRNEIQMVVLLLAI 228
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 442631927 363 IIAFLICWTPYYVMMIMFMFLNPDKRLGDDLqdaiFFFGMS--NSLVNPLIY 412
Cdd:cd14981  229 TVVFSVCWLPLMIRVLINATGDSEKNGKTDL----LAVRMAswNQILDPWVY 276
7tmA_NTSR1 cd15355
neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G ...
128-412 4.38e-11

neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320477 [Multi-domain]  Cd Length: 310  Bit Score: 64.48  E-value: 4.38e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 128 MALFSL--LGNLLTIWniykTRISRRNSRHTWSAIYSLMFHLSIADVLVTWFCIIGEA---AWCYTvQWLANELTCKLVK 202
Cdd:cd15355    8 LALFVVgtVGNSITLY----TLARKKSLQHLQSTVHYHLASLALSDLLILLLAMPVELynfIWVHH-PWAFGDAACRGYY 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 203 LFQMFSLYLSTYVLVLIGVDRWIAVKYPM--KSLNMAKRCHRLLGGTYILSLVLSLPQFFIfhvargpfVEEFYQCVTHG 280
Cdd:cd15355   83 FLRDACTYATALNVASLSVERYLAICHPFkaKSLMSRSRTKKFISAIWLASALLAIPMLFT--------MGEQNRSGTHP 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 281 FYTADWQEQMYATFTLV------FTFLLPLCILfgtymSTFRTISSSE--KMFQGSKLANYSTAKLPTQTNRQRLIHKAK 352
Cdd:cd15355  155 GGLICTPIVDTSTLKVViqvnafLSFLFPMLVI-----SVLNTLIANQltVMVNQAEQENQVCTIGGQRTVLSVSMEPGR 229
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 442631927 353 MKSLRISV----VIIIAFLICWTPYYVMMIMFMFLnPDKRLGDDLQDAIFFFGM-------SNSLVNPLIY 412
Cdd:cd15355  230 VQSLRHGVlvlrAVVIAFVVCWLPYHVRRLMFCYV-SDEQWTTFLYDFYHYFYMltnvlfyVSSAINPILY 299
7tmA_TAAR2_3_4 cd15312
trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...
124-416 4.78e-11

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320437 [Multi-domain]  Cd Length: 289  Bit Score: 63.91  E-value: 4.78e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 124 VLAVMALFSLLGNLLTIwniyktrISRRNSRHTWSAIYSLMFHLSIADVL----VTWFCIIGEAAWCytvqWLANELTCK 199
Cdd:cd15312    6 FMAGAILLTVFGNLMVI-------ISISHFKQLHSPTNFLILSLAITDFLlgflVMPYSMVRSVESC----WYFGDLFCK 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 200 LVKLFQMFSLYLSTYVLVLIGVDRWIAVKYPMK-SLNMAKRC-HRLLGGTYILSLVLSLPQFFIFHVARGpfVEEF---Y 274
Cdd:cd15312   75 IHSSLDMMLSTTSIFHLCFIAVDRYYAVCDPLHyRTKITTPViKVFLVISWSVPCLFAFGVVFSEVNLEG--IEDYvalV 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 275 QCVTHGFYTADwqeQMYATFTLVFTFLLPLCILFGTYMSTFRTISSSEKMFQGSKLANYSTAKLPTQTNRQRlihKAKmK 354
Cdd:cd15312  153 SCTGSCVLIFN---KLWGVIASLIAFFIPGTVMIGIYIKIFFVARKHAKVINNRPSVTKGDSKNKLSKKKER---KAA-K 225
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 442631927 355 SLRIsvvIIIAFLICWTPYYVMMIMFMFLN---PDkrlgdDLQDAIFFFGMSNSLVNPLIYGAFH 416
Cdd:cd15312  226 TLSI---VMGVFLLCWLPFFVATLIDPFLNfstPV-----DLFDALVWLGYFNSTCNPLIYGFFY 282
7tmA_GPR19 cd15008
G protein-coupled receptor 19, member of the class A family of seven-transmembrane G ...
124-416 4.90e-11

G protein-coupled receptor 19, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 19 is an orphan receptor that is expressed predominantly in neuronal cells during mouse embryogenesis. Its mRNA is found frequently over-expressed in patients with small cell lung cancer. GPR19 shares a significant amino acid sequence identity with the D2 dopamine and neuropeptide Y families of receptors. Human GPR19 gene, intronless in the coding region, also has a distribution in brain overlapping that of the D2 dopamine receptor gene, and is located on chromosome 12. GPR19 is a member of the class A family of GPCRs, which represents a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320137 [Multi-domain]  Cd Length: 275  Bit Score: 63.70  E-value: 4.90e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 124 VLAVMALFSLLGNLLTIWNIYKtrisrrnSRHTWSAIYSLMFHLSIADVLVTWFCIIGEAAWCYTVQWLANELTCKLVKL 203
Cdd:cd15008    5 VFGVLWLVSVFGNSLVCLVIHR-------SRRTQSTTNYFVVSMACADLLLSVASAPFVLLQFTSGRWTLGSAMCKLVRY 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 204 FQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLNMAKRCHRLLGGTYILSLVLSLPQFFIFHVARGPfveefyqcvTHGFYT 283
Cdd:cd15008   78 FQYLTPGVQIYVLLSICVDRFYTIVYPLSFKVSREKAKKMIAASWLFDAAFVSPALFFYGSNWGP---------HCNFFL 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 284 AD-WQEQMYATFTLVFTFLLP--LCILFgtYMSTFRTIsssekmfqgsklANYSTAKLpTQTNRQRLIHKAKMKSLRISV 360
Cdd:cd15008  149 PDsWDGAAYAIIHLLVGFLVPsiLIILF--YQKVIKYI------------WRIGTDGR-TVRRTMNIVPRTKVKTIKMFL 213
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 442631927 361 VIIIAFLICWTPYYVMMIMFMFLNpDKRLGDDLQDAIFFFGMSNSLVNPLIYGAFH 416
Cdd:cd15008  214 MLNSMFLLSWLPFYVVQLWHPRES-DYRQSSLVFLAVTWISFSSSASKPTLYSVYN 268
7tmA_MCHR1 cd15338
melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane ...
124-412 5.08e-11

melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320460 [Multi-domain]  Cd Length: 282  Bit Score: 64.06  E-value: 5.08e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 124 VLAVMALFSLLGNLLTIWNIYKTriSRRNSRHTWSAIYslMFHLSIADVLVTW---FCI---IGEAAWCYtvqwlaNELT 197
Cdd:cd15338    6 VFGVICFLGIIGNSIVIYTIVKK--SKFRCQQTVPDIF--IFNLSIVDLLFLLgmpFLIhqlLGNGVWHF------GETM 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 198 CKLVKLFQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLNMAKRC--HRLLGGTYILSLVLSLPQFFifHVARGPFVEEFYQ 275
Cdd:cd15338   76 CTLITALDTNSQITSTYILTVMTLDRYLATVHPIRSTKIRTPRvaVAVICLVWILSLLSITPVWM--YAGLMPLPDGSVG 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 276 CvthGFYTADWQEQMYaTFTL---VFTFLLPLCILFGTYMSTFRTISSSEkmfqgsklanystAKLPTQTNRQRlihkaK 352
Cdd:cd15338  154 C---ALLLPNPETDTY-WFTLyqfFLAFALPLVVICVVYFKILQNMASTV-------------APLPQRSLRVR-----T 211
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 442631927 353 MKSLRISVVIIIAFLICWTPYYVMMIMfmflnpdkRLGDDLQDAIFFF--------GMSNSLVNPLIY 412
Cdd:cd15338  212 KKVTRMAVAICLAFFICWAPFYILQLA--------HLSIDRPSLAFLYaynvaismGYANSCINPFLY 271
7tmA_Histamine_H2R cd15051
histamine subtype H2 receptor, member of the class A family of seven-transmembrane G ...
124-415 5.11e-11

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H2R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H2R subtype selectively interacts with the G(s)-type G protein that activates adenylate cyclase, leading to increased cAMP production and activation of Protein Kinase A. H2R is found in various tissues such as the brain, stomach, and heart. Its most prominent role is in histamine-induced gastric acid secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320179 [Multi-domain]  Cd Length: 287  Bit Score: 63.89  E-value: 5.11e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 124 VLAVMALFSLLGNLLTIWNIYktrISRRNSRHTWSAIYSLmfhlSIADVLVTWFCIIGEAAWCYTVQWLANELTCKL-VK 202
Cdd:cd15051    6 VLAVIILLTVIGNVLVCLAVA---VNRRLRNLTNYFIVSL----AVTDLLLGLLVLPFSAIYELRGEWPLGPVFCNIyIS 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 203 LFQMFSLyLSTYVLVLIGVDRWIAVKYPMK--SLNMAKRCHRLLGGTYILSLVLSlpqFFIFHVargpfveefyqcvthG 280
Cdd:cd15051   79 LDVMLCT-ASILNLFAISLDRYLAITAPLRypSRVTPRRVAIALAAIWVVSLAVS---FLPIHL---------------G 139
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 281 FYTADWQEQMYAT-----------FTLVF---TFLLPLCILFGTYMSTFRTISSSEKMFQGSKLANYSTAKLPTQTNRQr 346
Cdd:cd15051  140 WNTPDGRVQNGDTpnqcrfelnppYVLLVaigTFYLPLLIMCGVYLRIFRIAREQAKRINALTPASTANSSKSAATARE- 218
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 442631927 347 liHKAKMkSLRIsvvIIIAFLICWTPYYVMMIMFMFL--NPDKrlgdDLQDAIFFFGMSNSLVNPLIYGAF 415
Cdd:cd15051  219 --HKATV-TLAA---VLGAFIICWFPYFTYFTYRGLCgdNINE----TALSVVLWLGYANSALNPILYAFL 279
7tmA_Bombesin_R-like cd15927
bombesin receptor subfamily, member of the class A family of seven-transmembrane G ...
124-382 5.84e-11

bombesin receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This bombesin subfamily of G-protein coupled receptors consists of neuromedin B receptor (NMBR), gastrin-releasing peptide receptor (GRPR), and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple mainly to the G proteins of G(q/11) family. NMBR functions as the receptor for the neuropeptide neuromedin B, a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. Gastrin-releasing peptide is an endogenous ligand for GRPR and shares high sequence homology with NMB in the C-terminal region. Both NMB and GRP possess bombesin-like biochemical properties. BRS-3 is classified as an orphan receptor and suggested to play a role in sperm cell division and maturation. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. The bombesin receptor family belongs to the seven transmembrane rhodopsin-like G-protein coupled receptors (class A GPCRs), which perceive extracellular signals and transduce them to guanine nucleotide-binding (G) proteins.


Pssm-ID: 320593 [Multi-domain]  Cd Length: 294  Bit Score: 63.83  E-value: 5.84e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 124 VLAVMALFSLLGNLLTIWNIYKTRiSRRNSRHTwsaiysLMFHLSIADVLVTWFCIIGEAAwCYTV-QWLANELTCKLVK 202
Cdd:cd15927    6 LFALIFLVGVLGNGTLILIFLRNK-SMRNVPNI------FILSLALGDLLLLLTCVPFTST-IYTLdSWPFGEFLCKLSE 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 203 LFQMFSLYLSTYVLVLIGVDRWIAVKYPMK--SLNMAKRCHRLLGGTYILSLVLSLPQFFIFHVARGPFVEE--FYQCVT 278
Cdd:cd15927   78 FLKDTSIGVSVFTLTALSADRYFAIVNPMRkhRSQATRRTLVTAASIWIVSILLAIPEAIFSHVVTFTLTDNqtIQICYP 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 279 HGFYTADWQEQMYATFTLVFTFLLPLCILFGTYMSTFRT-ISSSEKMFQGSklanystaklPTQTNRQRlihKAKMKSLR 357
Cdd:cd15927  158 YPQELGPNYPKIMVLLRFLVYYLIPLLIIGVFYVLMARHlIRSTRNIGSGQ----------NQAAQRQI---EARKKVAK 224
                        250       260
                 ....*....|....*....|....*
gi 442631927 358 ISVVIIIAFLICWTPYYVMMIMFMF 382
Cdd:cd15927  225 TVLAFVVLFAVCWLPRHVFMLWFHF 249
7tmA_CXCR4 cd15179
CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G ...
166-415 6.32e-11

CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR4 is the only known G protein-coupled chemokine receptor for the key homeostatic ligand CXCL12, which is constitutively secreted by bone marrow stromal cells. Atypical chemokine receptor CXCR7 (ACKR3) also binds CXCL12, but activates signaling in a G protein-independent manner. CXCR4 is also a co-receptor for HIV infection and plays critical roles in the development of immune system during both lymphopoiesis and myelopoiesis. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341334 [Multi-domain]  Cd Length: 278  Bit Score: 63.63  E-value: 6.32e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 166 HLSIAD---VLVTWFCIIGEAAwcytvQWLANELTCKLVKLFQMFSLYLSTYVLVLIGVDRWIAVKYPMKSlnmaKRCHR 242
Cdd:cd15179   41 HLSVADllfVLTLPFWAVDAAA-----NWYFGNFLCKAVHVIYTVNLYSSVLILAFISLDRYLAIVHATNS----QRPRK 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 243 LL------GGTYILSLVLSLPQFFIFHVARgpfVEEFYQCvtHGFYTADWQEQMYATFT---LVFTFLLPLCILFGTYMS 313
Cdd:cd15179  112 LLaekvvyVGVWLPALLLTVPDLVFAKVSE---LDDRYIC--DRIYPEDTFELWVVAFRfqhILVGLVLPGLVILTCYCI 186
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 314 TFRTISSSekmfqgsklanystaklptqTNRQrlihkaKMKSLRISVVIIIAFLICWTPYYVMMIM--FMFL---NPDKR 388
Cdd:cd15179  187 IISKLSHS--------------------KGHQ------KRKALKTTVILILAFFACWLPYYIGISIdtFMLLeiiKQSCE 240
                        250       260       270
                 ....*....|....*....|....*....|
gi 442631927 389 LGDDLQDAIFF---FGMSNSLVNPLIYgAF 415
Cdd:cd15179  241 MEQTVHKWISIteaLAFFHCCLNPILY-AF 269
7tmA_TAAR1 cd15314
trace amine-associated receptor 1 and similar receptors, member of the class A family of ...
124-416 8.49e-11

trace amine-associated receptor 1 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 1 (TAAR1) is one of the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. TAAR1 is coupled to the Gs protein, which leads to activation of adenylate cyclase, and is thought to play functional role in the regulation of brain monoamines. TAAR1 is also shown to be activated by psychoactive compounds such as Ecstasy (MDMA), amphetamine and LSD. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320438 [Multi-domain]  Cd Length: 282  Bit Score: 63.03  E-value: 8.49e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 124 VLAVMALFSLLGNLLTIwniyktrISRRNSRHTWSAIYSLMFHLSIADVLVTwfCIIGEAAWCYTVQ--WLANELTCKLV 201
Cdd:cd15314    6 FLGLISLVTVCGNLLVI-------ISIAHFKQLHTPTNYLILSLAVADLLVG--GLVMPPSMVRSVEtcWYFGDLFCKIH 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 202 KLFQMFSLYLSTYVLVLIGVDRWIAVkypmkslnmakrCHRLLGGTYILSLVL--------SLPQFFIFHVargPFVE-- 271
Cdd:cd15314   77 SSFDITLCTASILNLCFISIDRYYAV------------CQPLLYRSKITVRVVlvmiliswSVSALVGFGI---IFLEln 141
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 272 ------EFYQCVTHGFYTadwQEQMYATFTLVFTFLLPLCILFGTYMstfrtissseKMF-----QGSKLANYSTAKLPT 340
Cdd:cd15314  142 ikgiyyNHVACEGGCLVF---FSKVSSVVGSVFSFYIPAVIMLCIYL----------KIFlvaqrQARSIQSARTKSGAS 208
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 442631927 341 QTNRQRlihKAkMKSLrisVVIIIAFLICWTPYYVMMIMFMFLN---PDKrlgddLQDAIFFFGMSNSLVNPLIYGAFH 416
Cdd:cd15314  209 SSKMER---KA-TKTL---AIVMGVFLLCWTPFFLCNIIDPFINysiPPV-----LIEVLNWLGYSNSTLNPFIYAFFY 275
7tmA_Apelin_R cd15190
apelin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
130-417 1.03e-10

apelin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Apelin (APJ) receptor is a G protein-coupled receptor that binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake.


Pssm-ID: 341340 [Multi-domain]  Cd Length: 304  Bit Score: 63.24  E-value: 1.03e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 130 LFSLLGNLLTIWNIYKTRISRRNSRHTWSAiyslmfHLSIADVLVtwfcIIGEAAWC-YTVQ---WLANELTCKLVKLFQ 205
Cdd:cd15190   22 VLGLSGNGLVLWTVFRSKRKRRRSADTFIA------NLALADLTF----VVTLPLWAvYTALgyhWPFGSFLCKLSSYLV 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 206 MFSLYLSTYVLVLIGVDRWIAVKYPMKSLNMAKRCHRL--LGGTYILSLVLSLPQFfIFHVARGPFVEEFYQCVTHGFYT 283
Cdd:cd15190   92 FVNMYASVFCLTGLSFDRYLAIVRSLASAKLRSRTSGIvaLGVIWLLAALLALPAL-ILRTTSDLEGTNKVICDMDYSGV 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 284 ADWQEQMYATFTL-----VFTFLLPLCILFGTYMSTFRTISSsekmfqgsklaNYSTAKLPTQTNRQRLihkakmksLRI 358
Cdd:cd15190  171 VSNESEWAWIAGLglsstVLGFLLPFLIMLTCYFFIGRTVAR-----------HFSKLRRKEDKKKRRL--------LKI 231
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 442631927 359 SVVIIIAFLICWTPYYVM----MIMFMFLNPDKRLGDDLQDAIFFF----GMSNSLVNPLIYGAFHL 417
Cdd:cd15190  232 IITLVVTFALCWLPFHLVktlyALMYLGILPFSCGFDLFLMNAHPYatclAYVNSCLNPFLYAFFDP 298
7tmA_CCR6 cd15172
CC chemokine receptor type 6, member of the class A family of seven-transmembrane G ...
124-379 1.22e-10

CC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR6 is the only known receptor identified for the chemokine CCL20 (also known as macrophage inflammatory protein-3alpha, MIP-3alpha). CCR6 is expressed by all mature human B cells, effector memory T-cells, and dendritic cells found in the gut mucosal immune system. CCL20 contributes to recruitment of CCR6-expressing cells to Peyer's patches and isolated lymphoid follicles in the intestine, thereby promoting the assembly and maintenance of organized lymphoid structures. Also, CCL20 expression is highly inducible in response to inflammatory signals. Thus, CCL20 is involved in both inflammatory and homeostatic functions in the immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341330 [Multi-domain]  Cd Length: 281  Bit Score: 62.85  E-value: 1.22e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 124 VLAVMALFSLLGNLLTIwniyktrISRRNSRHTWSAIYSLMFHLSIAD---VLVTWFCIIGEAAwcytvQWLANELTCKL 200
Cdd:cd15172    6 IYSLICVVGLIGNSLVV-------ITYAFYKRTKSMTDVYLLNMAIADilfVLTLPFWAVYEAH-----QWIFGNFSCKL 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 201 VKLFQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLNMAKRC----HRLLGGTYILSLVLSLPQFFifhvargpfveeFYQC 276
Cdd:cd15172   74 LRGIYAINFYSGMLLLACISVDRYIAIVQATKSFRLRSRTlaysKLICAAVWLLAILISLPTFI------------FSEV 141
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 277 VTHGF---------YTADWQEQMYATFTLV----FTFLLPLCILFGTYMSTFRTISSSEkmfqgsklanystaklptqtN 343
Cdd:cd15172  142 YDFGLeeqyvcepkYPKNSTAIMWKLLVLSlqvsLGFFIPLLVMIFCYSFIIKTLLQAQ--------------------N 201
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 442631927 344 RQRliHKAkmksLRISVVIIIAFLICWTPYYVMMIM 379
Cdd:cd15172  202 SQR--HKA----VRVVVAVVLVFLVCQVPYNIVLLI 231
7tmA_GPR45 cd15403
G protein-coupled receptor 45, member of the class A family of seven-transmembrane G ...
124-382 1.25e-10

G protein-coupled receptor 45, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the human orphan receptor GPR45 and closely related proteins found in vertebrates. GPR45 is also called PSP24 in Xenopus and PSP24-alpha (or PSP24-1) in mammals. GPR45 shows the highest sequence homology with GPR63 (PSP24-beta, or PSP24-2). PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Mammalian PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320525 [Multi-domain]  Cd Length: 301  Bit Score: 62.94  E-value: 1.25e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 124 VLAVMALFSLLGNLLTIWNIYKTRISRrnsrhtwSAIYSLMFHLSIADVLVTWFCIIGEAAWCYTVQWLANELTCKLVKL 203
Cdd:cd15403    6 VMILMIAIGFLGNAIVCLIVYQKPAMR-------SAINLLLATLAFSDIMLSLLCMPFTAVTIITVDWHFGAHFCRISAM 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 204 FQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLNmAKRCHRLLGGTYILSLVLSLPQFFIFHVARGPfvEEFYQCVTHgfYT 283
Cdd:cd15403   79 LYWFFVLEGVAILLIISVDRFLIIVQRQDKLN-PHRAKVMIAISWVLSFCISFPSVVGWTLVEVP--ARAPQCVLG--YT 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 284 ADWQEQMYATFTLVFTFLLPLCILFGTYMSTFRTI----------SSSEKMFQGSKLANYSTAKlPTQTNrqrLIHKAKM 353
Cdd:cd15403  154 ESPADRVYAVLLVVAVFFVPFSIMLYSYLCILNTVrrnavrihnhADSLCLSQVSKLGLMGLQR-PHQMN---VDMSFKT 229
                        250       260
                 ....*....|....*....|....*....
gi 442631927 354 KSLRISVVIIIAFLICWTPYYVMMIMFMF 382
Cdd:cd15403  230 RAFTTILILFVGFSLCWLPHTVFSLLSVF 258
7tmA_NOFQ_opioid_R cd15092
nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G ...
122-412 1.42e-10

nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The nociceptin (NOP) receptor binds nociceptin or orphanin FQ, a 17 amino acid endogenous neuropeptide. The NOP receptor is involved in the modulation of various brain activities including instinctive and emotional behaviors. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320220 [Multi-domain]  Cd Length: 279  Bit Score: 62.58  E-value: 1.42e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 122 VYVLAVMALFSLLGNLLTIWNIYktrisRRNSRHTWSAIYslMFHLSIADVLVTwFCIIGEAAWCYTVQWLANELTCKLV 201
Cdd:cd15092    4 VVVYLIVCVVGLVGNCLVMYVIL-----RHTKMKTATNIY--IFNLALADTLVL-LTLPFQGTDIFLGFWPFGNALCKTV 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 202 KLFQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLNM--AKRCHRLLGGTYILSLVLSLPQFFIFHVARGpfvEEFYQCVTH 279
Cdd:cd15092   76 IAIDYYNMFTSTFTLTAMSVDRYVAICHPIKALDVrtPHKAKVVNVCIWALASVVGVPVMVMGSAQVE---DEEIECLVE 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 280 GFYTADWQEQMYATFTLVFTFLLPLCILFGTYMSTFRTISSSeKMFQGSKlanystaklPTQTNRQRLIhkakmkslRIS 359
Cdd:cd15092  153 IPTPQDYWDPVFGICVFLFSFIIPVLIISVCYSLMIRRLRGV-RLLSGSK---------EKDRNLRRIT--------RLV 214
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 442631927 360 VVIIIAFLICWTPYYVM-MIMFMFLNPDKrlgdDLQDAIFFF----GMSNSLVNPLIY 412
Cdd:cd15092  215 LVVVAVFVGCWTPIQIFvLAQGLGVQPSS----ETAVAILRFctalGYVNSSLNPVLY 268
7tmA_Octopamine_R cd15063
octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...
119-415 1.93e-10

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.


Pssm-ID: 320191 [Multi-domain]  Cd Length: 266  Bit Score: 61.74  E-value: 1.93e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 119 LLKVYVLAVMALFSLLGNLLTIWNIYKTRISRrnsrhtwSAIYSLMFHLSIADVLVTWFCIIGEAAWCYTVQWLANELTC 198
Cdd:cd15063    1 LISLLVLTFLNVLVVLGNLLVIAAVLCSRKLR-------TVTNLFIVSLACADLLVGTLVLPFSAVNEVLDVWIFGHTWC 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 199 KLVKLFQMFSLYLSTYVLVLIGVDRWIAVKYPMK--SLNMAKRCHRLLGGTYILSLVLSLPQFFIFHVARGPFVEEFY-- 274
Cdd:cd15063   74 QIWLAVDVWMCTASILNLCAISLDRYLAITRPIRypSLMSTKRAKCLIAGVWVLSFVICFPPLVGWNDGKDGIMDYSGss 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 275 QCVTHGFYTADwqeQMYATFTLVFTFLLPLCILFGTYMSTFRTISSSEKmfqgsklanystaklptqtnrqrlihkaKMK 354
Cdd:cd15063  154 SLPCTCELTNG---RGYVIYSALGSFYIPMLVMLFFYFRIYRAARMETK----------------------------AAK 202
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 442631927 355 SLRIsvvIIIAFLICWTPYYVMMIMFMFLnpDKRLGDDLQDAIFFFGMSNSLVNPLIYGAF 415
Cdd:cd15063  203 TVAI---IVGCFIFCWLPFFTVYLVRAFC--EDCIPPLLFSVFFWLGYCNSALNPCIYALF 258
7tmA_DmOct-betaAR-like cd15066
Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar ...
120-415 2.03e-10

Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar receptors in bilateria; member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila beta-adrenergic-like octopamine receptors and similar proteins. The biogenic amine octopamine is the invertebrate equivalent of vertebrate adrenergic neurotransmitters and exerts its effects through different G protein-coupled receptor types. Insect octopamine receptors are involved in the modulation of carbohydrate metabolism, muscular tension, cognition and memory. The activation of octopamine receptors mediating these actions leads to an increase in adenylate cyclase activity, thereby increasing cAMP levels. In Drosophila melanogaster, three subgroups have been classified on the basis of their structural homology and functional equivalents with vertebrate beta-adrenergic receptors: DmOctBeta1R, DmOctBeta2R, and DmOctBeta3R.


Pssm-ID: 320194 [Multi-domain]  Cd Length: 265  Bit Score: 62.01  E-value: 2.03e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 120 LKVYVLAVMALFSLLGNLLTIWNIYKTRISRRNsrhTWSAIYSLMFhlsiADVLVTWFCIIGEAAWCYTVQWLANELTCK 199
Cdd:cd15066    1 LKGFAMTLIILAAIFGNLLVIISVMRHRKLRVI---TNYFVVSLAM----ADMLVALCAMTFNASVEITGRWMFGYFMCD 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 200 LvklFQMFSLYLSTYV---LVLIGVDRWIAV----KYPMKSLNmaKRCHRLLGGTYILSLVLSlpqfFIfhvargPFVEE 272
Cdd:cd15066   74 V---WNSLDVYFSTASilhLCCISVDRYYAIvqplEYPSKMTK--RRVAIMLANVWISPALIS----FL------PIFLG 138
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 273 FYQCVTHGFYTADWQEQ-------MYATFTLVFTFLLPLCILFGTYMSTFRtisssekmfqgsklanystaklptQTNRQ 345
Cdd:cd15066  139 WYTTEEHLQYRKTHPDQcefvvnkIYALISSSVSFWIPCIVMIFTYYRIYL------------------------EAKRE 194
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 346 rliHKAKmKSLRIsvvIIIAFLICWTPYYVMMIMFMFLNPDKRLGDDLQDAIFFFGMSNSLVNPLIYGAF 415
Cdd:cd15066  195 ---HKAA-KTLGI---IMGAFILCWLPFFLWYVTTTLCGDACPYPPILVSILFWIGYFNSTLNPLIYAYF 257
7tmA_CysLTR1 cd15158
cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G ...
121-412 2.36e-10

cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320286 [Multi-domain]  Cd Length: 285  Bit Score: 62.07  E-value: 2.36e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 121 KVY--VLAVMALFSLLGNLLTIWNIYKTRisrrnsrHTWSAIYSLMFHLSIADVLVTWFCIIGEAAWCYTVQWLANELTC 198
Cdd:cd15158    1 QVYstLYSVITVFGLVGNGFALYVLIKTY-------RQKSAFHIYMLNLAVSDLLCVCTLPLRVVYYVHKGQWLFGDFLC 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 199 KLVKLFQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLNMA--KRCHRLLGGTYILSLVLSLPqfFIFHVARGPFVEEfyqc 276
Cdd:cd15158   74 RISSYALYVNLYCSIYFMTAMSFTRFLAIVFPVQNLNLVtvKKARIVCVGIWIFVTLTSSP--FLMSGSHDTETNK---- 147
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 277 vTHGFYTADWQEQMYAT-----FTLVFTFLLPLCILFGTYMSTFRTIsssekmfqgskLANYSTAklptqtNRQRLIHKa 351
Cdd:cd15158  148 -TKCFEPPQSNQQLTKLlvlnyISLVVGFIIPFLVILICYAMIIRTL-----------LKNTMKA------RKQQSSRK- 208
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 442631927 352 kmKSLRISVVIIIAFLICWTPYYVM-MIMFMFLNPDKRLGDD---LQDAIFF---FGMSNSLVNPLIY 412
Cdd:cd15158  209 --KAIRMIIIVLLAFLVSFMPYHIQrTIHLHFLSRKDSTCEEvlyMQKSVVItlcLAAANCCFDPLLY 274
7tmA_SSTR4 cd15973
somatostatin receptor type 4, member of the class A family of seven-transmembrane G ...
123-415 2.39e-10

somatostatin receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR4 plays a critical role in mediating inflammation. Unlike other SSTRs, SSTR4 subtype is not detected in all pituitary adenomas while it is expressed in the normal human pituitary.


Pssm-ID: 320639 [Multi-domain]  Cd Length: 274  Bit Score: 61.80  E-value: 2.39e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 123 YVLAVMALFSLLGNLLTIWNIYktrisRRNSRHTWSAIYSLmfHLSIADVLVTwFCIIGEAAWCYTVQWLANELTCKLVK 202
Cdd:cd15973    5 FIYALVCLVGLIGNSMVIFVIL-----RYAKMKTATNIYIL--NLAIADELFM-LSVPFLAASAALQHWPFGSAMCRTVL 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 203 LFQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLNMAK-RCHRLL-GGTYILSLVLSLPqfFIFHVARGPFVEEFYQCvthg 280
Cdd:cd15973   77 SVDGINMFTSVFCLTVLSVDRYIAVVHPLRAARYRRpTVAKMInICVWILSLLVISP--IIIFADTATRKGQAVAC---- 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 281 fyTADWQEQMYATFTLVFTFLLPLCI-LFGTYMSTFRTISsseKMFQGSKLANYstaklptqtnRQRliHKAKMKSLRIS 359
Cdd:cd15973  151 --NLIWPHPAWSAAFVIYTFLLGFLLpVLAIGLCYILIIG---KMRAVALKAGW----------QQR--RKSEKKITRMV 213
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 442631927 360 VVIIIAFLICWTPYYVMMIMFMFLnpdKRLGDDLQDAIFFFGMSNSLVNPLIYGAF 415
Cdd:cd15973  214 LMVVTVFVICWMPFYVVQLLNLFL---PRLDATVNHASLILSYANSCANPILYGFL 266
7tmA_NPFFR2 cd15980
neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G ...
153-416 2.41e-10

neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320646 [Multi-domain]  Cd Length: 299  Bit Score: 62.21  E-value: 2.41e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 153 SRHTWSAIYSLMFHLSIADVLVTWFCIIGEAAWCYTVQWLANELTCKLVKLFQMFSLYLSTYVLVLIGVDRWIAVKYPMK 232
Cdd:cd15980   28 SKHMRTVTNLFILNLAISDLLVGIFCMPTTLLDNIIAGWPFGSTVCKMSGMVQGISVSASVFTLVAIAVDRFRCIVYPFK 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 233 SLNMAKRCHRLLGGTYILSLVLSLPQFFIFHVARGPFVEEF--YQCVTHGFY--TADWQEQ----MYATFTLVFTFLLPL 304
Cdd:cd15980  108 QKLTISTAVVIIVIIWVLAIAIMCPSAVMLHVQEEKNYRVVlgSQNKTSPVYwcREDWPNQemrkIYTTVLFANIYLAPL 187
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 305 CILFGTYMSTFRTISSSEKMFQGSKlanystaklpTQTNRQrLIHKAKMKSLRISVVIIIAFLICWTPYYVMMIMFMFLN 384
Cdd:cd15980  188 SLIVIMYARIGITLFKTAMPHTGKH----------NQEQRH-VVSRKKQKVIKMLLIVALLFILSWLPLWTLMMLSDYAN 256
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 442631927 385 PDKRLGDDLQDAIFFF----GMSNSLVNPLIYGAFH 416
Cdd:cd15980  257 LSPNQLQIINIYIYPFahwlAFFNSSVNPIIYGFFN 292
7tmA_CCK-BR cd15979
cholecystokinin receptor type B, member of the class A family of seven-transmembrane G ...
120-412 2.86e-10

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320645 [Multi-domain]  Cd Length: 275  Bit Score: 61.37  E-value: 2.86e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 120 LKVYVLAVMALFSLLGNLLTIWNIYKTRISRrnsrhtwSAIYSLMFHLSIADVLVTWFCIIGEAAWCYTVQWLANELTCK 199
Cdd:cd15979    2 VRILLYSVIFLLSVFGNMLIIVVLGLNKRLR-------TVTNSFLLSLALSDLMLAVFCMPFTLIPNLMGTFIFGEVICK 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 200 LVKLFQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLNMAKRCH--RLLGGTYILSLVLSLPQFFIFHVARGPFVEE--FYQ 275
Cdd:cd15979   75 AVAYLMGVSVSVSTFSLVAIAIERYSAICNPLQSRVWQTRSHayRVIAATWLLSGLIMIPYPVYSVTVPVPVGDRprGHQ 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 276 CvTHGFYTADWQeQMYATFTLVFTFLLPlcilfGTYMSTFRTISSSEkMFQGsklanystaklptqtnrqrLIhkAKMKS 355
Cdd:cd15979  155 C-RHAWPSAQVR-QAWYVLLLLILFFIP-----GVVMIVAYGLISRE-LYRG-------------------LL--AKKRV 205
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 442631927 356 LRISVVIIIAFLICWTPYYVMMIMFMF--LNPDKRLGDDLQDAIFFFGMSNSLVNPLIY 412
Cdd:cd15979  206 IRMLVVIVAMFFLCWLPIFSANTWRAFdpLSAHRALSGAPISFIHLLSYTSACVNPLVY 264
7tmA_P2Y1 cd15377
P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
119-412 2.96e-10

P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y1 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. This family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 341350 [Multi-domain]  Cd Length: 289  Bit Score: 61.85  E-value: 2.96e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 119 LLKVYVLAVMALFslLGNLLTIWN-IYKTRisrrnsrhTWSAIYSLMFHLSIAD---VLVTWFCIIgeaAWCYTVQWLAN 194
Cdd:cd15377    3 LPAVYILVFITGF--LGNSVAIWMfVFHMK--------PWSGISVYMFNLALADflyVLTLPALIF---YYFNKTDWIFG 69
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 195 ELTCKLVKLFQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLNMAKRCHRLLGGTYILSLVLSLPQFFIFHVARGPFVEEFY 274
Cdd:cd15377   70 DAMCKLQRFIFHVNLYGSILFLTCISVHRYTGVVHPLKSLGRLKKKNAICISVLVWLIVVVAISPILFYSGTGVRKNKTI 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 275 QCvthgfYTADWQEQM-----YATFTLVFTFLLPLCILFGTYMSTFRTISSSEKMFqgsklanystaklpTQTNRQRLih 349
Cdd:cd15377  150 TC-----YDTTSDEYLrsyfiYSMCTTVAMFCVPFILILGCYGLIVRALIYKDMKY--------------TEENNAPL-- 208
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 442631927 350 kaKMKSLRISVVIIIAFLICWTPYYVMMIMFM-----FLNPDKRLGDDLQDAIFFF--GMS--NSLVNPLIY 412
Cdd:cd15377  209 --RRKSIYLVIIVLTVFAVSYLPFHVMKTLNLrarldFQTPAMCAFNDRVYATYQVtrGLAslNSCVDPILY 278
7tmA_GPR35_55-like cd15923
G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of ...
119-408 4.80e-10

G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily is composed of GPR35, GPR55, and similar proteins. GPR35 shares closest homology with GPR55, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A number of studies have suggested that GPR35 may play important physiological roles in hypertension, atherosclerosis, nociception, asthma, glucose homeostasis and diabetes, and inflammatory bowel disease. GPR35 is thought to be responsible for brachydactyly mental retardation syndrome, which is associated with a deletion comprising chromosome 2q37 in human, and is also implicated as a potential oncogene in stomach cancer. GPR35 couples to G(13) and G(i/o) proteins, whereas GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Recently, lysophosphatidylinositol (LPI) has been identified as an endogenous ligand for GPR55, while several endogenous ligands for GPR35 have been identified including kynurenic acid, 2-oleoyl lysophosphatidic acid, and zaprinast.


Pssm-ID: 320589 [Multi-domain]  Cd Length: 273  Bit Score: 60.93  E-value: 4.80e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 119 LLKVYVLAVMALFSLLGNLLTIWnIYKTRISRRnsrhTWSAIYslMFHLSIADVLVtwFCIIGEAAWCYTVQWLANELTC 198
Cdd:cd15923    1 LLQYAIYIPTFVLGLLLNILALW-VFCWRLKKW----TETNIY--MTNLAVADLLL--LISLPFKMHSYRRESAGLQKLC 71
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 199 KLVKLFQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLNMaKRCHRLLG--GTYILSLVLSLPQFFIFHVArgpfvEEFYQC 276
Cdd:cd15923   72 NFVLSLYYINMYVSIFTITAISVDRYVAIRYPLRAREL-RSPRKAAVvcAVIWVLVVTISIPYFLLDSS-----NEKTMC 145
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 277 vthgFYTADWQEQMYATFTL-VFTFLLPLCILfgTYMStFRTIsssekmfqgsklanystaklptQTNRQRLIH----KA 351
Cdd:cd15923  146 ----FQRTKQTESLKVFLLLeIFGFLLPLIIM--TFCS-ARVI----------------------HTLQKRLDDvgsrSE 196
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 442631927 352 KMKSLRISVVIIIAFLICWTPYYVMMIMfMFLNPDKRLGDDLQDAIFFFGMSNSLVN 408
Cdd:cd15923  197 TKQCIRVIMANLIVFIVCFLPVHVGFFV-KFIVGKSYSCDSKLIIHFFLQSAFCLSD 252
7tmA_MWS_opsin cd15080
medium wave-sensitive opsins, member of the class A family of seven-transmembrane G ...
198-412 5.24e-10

medium wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Medium Wave-Sensitive opsin, which mediates visual transduction in response to light at medium wavelengths (green). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 381742 [Multi-domain]  Cd Length: 280  Bit Score: 60.62  E-value: 5.24e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 198 CKLVKLFQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLNMAKRcHRLLG--GTYILSLVLSLPQFFifhvARGPFVEEFYQ 275
Cdd:cd15080   73 CNLEGFFATLGGEIALWSLVVLAIERYVVVCKPMSNFRFGEN-HAIMGvaFTWVMALACAAPPLV----GWSRYIPEGMQ 147
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 276 CVTH-GFYT--ADWQEQMYATFTLVFTFLLPLCILFGTYMSTFRTISSSEKMFQGSklanystakLPTQtnrqrlihKAK 352
Cdd:cd15080  148 CSCGiDYYTlkPEVNNESFVIYMFVVHFTIPLIVIFFCYGRLVCTVKEAAAQQQES---------ATTQ--------KAE 210
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 353 MKSLRISVVIIIAFLICWTPyYVMMIMFMFLNPDKRLGDDLQDAIFFFGMSNSLVNPLIY 412
Cdd:cd15080  211 KEVTRMVIIMVIAFLICWVP-YASVAFYIFTHQGSDFGPIFMTIPAFFAKSSAVYNPVIY 269
7tmA_CCK-AR cd15978
cholecystokinin receptor type A, member of the class A family of seven-transmembrane G ...
120-412 5.74e-10

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320644 [Multi-domain]  Cd Length: 278  Bit Score: 60.65  E-value: 5.74e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 120 LKVYVLAVMALFSLLGNLLTIwniykTRISRRNSRHTWSAIYslMFHLSIADVLVTWFCIIGEAAWCYTVQWLANELTCK 199
Cdd:cd15978    2 VRILLYSLIFLLSVLGNSLII-----AVLIRNKRMRTVTNIF--LLSLAVSDLMLCLFCMPFTLIPNLLKDFIFGSAVCK 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 200 LVKLFQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLNMAKRCH--RLLGGTYILSLVLSLPqfFIFHVARGPFVEEFYQC- 276
Cdd:cd15978   75 TATYFMGISVSVSTFNLVAISLERYSAICKPLKSRVWQTKSHalKVIAATWCLSFTIMLP--YPIYSNLVPFTRINNSTg 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 277 -VTHGFYTADWQEQMYATFTLVFTFLLPlcilfGTYMSTFRTISSSEkMFQGSKLAnystaklptqtnrqrlihKAKMKS 355
Cdd:cd15978  153 nMCRLLWPNDVTQQSWYIFLLLILFLIP-----GIVMMTAYGLISLE-LYRGIKFL------------------MAKKRV 208
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 442631927 356 LRISVVIIIAFLICWTPYYVMMIMFMF--LNPDKRLGDDLQDAIFFFGMSNSLVNPLIY 412
Cdd:cd15978  209 IRMLIVIVILFFLCWTPIFSANAWRAFdtRSADRLLSGAPISFIHLLSYTSACVNPIIY 267
7tmA_GPR84-like cd15210
G protein-coupled receptor 84 and similar proteins, member of the class A family of ...
122-308 6.19e-10

G protein-coupled receptor 84 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR84, also known as the inflammation-related G-Protein coupled receptor EX33, is a receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Among these medium-chain FFAs, capric acid (C10:0), undecanoic acid (C11:0), and lauric acid (C12:0) are the most potent endogenous agonists of GPR84, whereas short-chain and long-chain saturated and unsaturated FFAs do not activate this receptor. GPR84 contains a [G/N]RY-motif instead of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors and important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. In the case of GPR84, activation of the receptor couples to a pertussis toxin sensitive G(i/o)-protein pathway. GPR84 knockout mice showed increased Th2 cytokine production including IL-4, IL-5, and IL-13 compared to wild-type mice. It has been also shown that activation of GPR84 augments lipopolysaccharide-stimulated IL-8 production in polymorphonuclear leukocytes and TNF-alpha production in macrophages, suggesting that GPR84 may function as a proinflammatory receptor.


Pssm-ID: 320338 [Multi-domain]  Cd Length: 254  Bit Score: 60.36  E-value: 6.19e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 122 VYVLAVMALfSLLGNLLTIWNIYKTRisrrnSRHTWSAIysLMFHLSIADVLvtwFCIIG---EAAWCYTVQWLANELTC 198
Cdd:cd15210    5 VWGIVFMVV-GVPGNLLTVLALLRSK-----KLRTRTNA--FIINLSISDLL---FCAFNlplAASTFLHQAWIHGETLC 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 199 KLVKLFQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLNMAKRCH--RLLGGTYILSLVLSLPQFFIFhVARGPFVEEFYQC 276
Cdd:cd15210   74 RVFPLLRYGLVAVSLLTLVLITLNRYILIAHPSLYPRIYTRRGlaLMIAGTWIFSFGSFLPLWLGI-WGRFGLDPKVCSC 152
                        170       180       190
                 ....*....|....*....|....*....|...
gi 442631927 277 VTHgfytADWQEQMYATFTLVFTFLLP-LCILF 308
Cdd:cd15210  153 SIL----RDKKGRSPKTFLFVFGFVLPcLVIII 181
7tmA_SSTR5 cd15974
somatostatin receptor type 5, member of the class A family of seven-transmembrane G ...
119-413 8.68e-10

somatostatin receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR5 is coupled to inward rectifying K channels and phospholipase C, and plays critical roles in growth hormone and insulin secretion. SSTR5 acts as a negative regulator of PDX-1 (pancreatic and duodenal homeobox-1) expression, which is a conserved homeodomain-containing beta cell-specific transcription factor essentially involved in pancreatic development, among many other functions.


Pssm-ID: 320640 [Multi-domain]  Cd Length: 277  Bit Score: 60.20  E-value: 8.68e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 119 LLKVYVLAVMALfSLLGNLLTIWNIYktrisRRNSRHTWSAIYSLmfHLSIADVLVtwfcIIG------EAAWCYtvqWL 192
Cdd:cd15974    2 LIPVIYLLVCAI-GLSGNTLVIYVVL-----RYAKMKTVTNIYIL--NLAVADELF----MLGlpflatQNAISY---WP 66
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 193 ANELTCKLVKLFQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLNMAK-RCHRLLGGT-YILSLVLSLPQFFIFHVArgpfv 270
Cdd:cd15974   67 FGSFLCRLVMTVDGVNQFTSIFCLTVMSIDRYLAVVHPIKSTKWRRpRVAKLINATvWTLSFLVVLPVIIFSDVQ----- 141
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 271 EEFYQCvthgfyTADWQEQM------YATFTLVFTFLLPLCILFGTYMSTFRTISSSekmfqgsklanystaKLPTQTNR 344
Cdd:cd15974  142 PDLNTC------NISWPEPVsvwstaFIIYTAVLGFFGPLLVICLCYLLIVIKVKSS---------------GLRVGSTK 200
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 442631927 345 QRlihKAKMKSLRISVVIIIAFLICWTPYYVMMIM-FMFLNPDkrlgDDLQDAIFFFGM----SNSLVNPLIYG 413
Cdd:cd15974  201 RR---KSERKVTRMVVIIVVVFVFCWLPFYMLNIVnLIVILPE----EPAFVGVYFFVVvlsyANSCANPILYG 267
7tmA_SSTR1 cd15970
somatostatin receptor type 1, member of the class A family of seven-transmembrane G ...
123-413 9.22e-10

somatostatin receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR1 is coupled to a Na/H exchanger, voltage-dependent calcium channels, and AMPA/kainate glutamate channels. SSTR1 is expressed in the normal human pituitary and in nearly half of all pituitary adenoma subtypes.


Pssm-ID: 320636 [Multi-domain]  Cd Length: 276  Bit Score: 59.93  E-value: 9.22e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 123 YVLAVMALFSLLGNLLTIWNIYktrisRRNSRHTWSAIYSLmfHLSIADVLVTwFCIIGEAAWCYTVQWLANELTCKLVK 202
Cdd:cd15970    5 FIYSVVCLVGLCGNSMVIYVIL-----RYAKMKTATNIYIL--NLAIADELLM-LSVPFLVTSTLLRHWPFGSLLCRLVL 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 203 LFQMFSLYLSTYVLVLIGVDRWIAVKYPMKSL-----NMAKRCHRllgGTYILSLVLSLPqfFIFHVARGPFVEEFYQCV 277
Cdd:cd15970   77 SVDAINMFTSIYCLTVLSIDRYIAVVHPIKAAryrrpTVAKMVNL---GVWVFSILVILP--IIIFSNTAPNSDGSVACN 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 278 THGFYTADWQEQMYATFTLVFTFLLP---LCILFGTYMSTFRTISSSekmfqgsklANYSTAKlptqtnrqrlihKAKMK 354
Cdd:cd15970  152 MQMPEPSQRWLAVFVVYTFLMGFLLPviaICLCYILIIVKMRVVALK---------AGWQQRK------------RSERK 210
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 442631927 355 SLRISVVIIIAFLICWTPYYVMMIMFMFLNPDKRLGDDLQDAIfffGMSNSLVNPLIYG 413
Cdd:cd15970  211 ITLMVMMVVTVFVICWMPFYVVQLVSVFVGQHDATVSQLSVIL---GYANSCANPILYG 266
7tmA_alpha2_AR cd15059
alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G ...
122-415 9.37e-10

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320187 [Multi-domain]  Cd Length: 261  Bit Score: 59.66  E-value: 9.37e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 122 VYVLAVMALFSLLGNLLTIWNIYKTRISRRnsRHTWsaiysLMFHLSIADVLVTwfCIIGEAAWCYTV--QWLANELTCK 199
Cdd:cd15059    4 SSIVSVVILLIIVGNVLVIVAVLTSRKLRA--PQNW-----FLVSLAVADILVG--LLIMPFSLVNELmgYWYFGSVWCE 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 200 LVKLFQMFSLYLSTYVLVLIGVDRWI----AVKYPMKSlnMAKRCHRLLGGTYILSLVLSLPQFFIFHVARGPfVEEFYQ 275
Cdd:cd15059   75 IWLALDVLFCTASIVNLCAISLDRYWsvtqAVEYNLKR--TPRRAKAMIAAVWIISAVISLPPLFGWKDEQPW-HGAEPQ 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 276 CvthGFYTADWqeqmYATFTLVFTFLLPLCILFGTYMSTFRTISSSEKMFQgsklanystaklptqtnrqrlihkakmks 355
Cdd:cd15059  152 C---ELSDDPG----YVLFSSIGSFYIPLLIMIIVYARIYRAAKRKERRFT----------------------------- 195
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 356 lRISVVIIIAFLICWTPYYVMMIMfMFLNPDKRLGDDLQDAIFFFGMSNSLVNPLIYGAF 415
Cdd:cd15059  196 -LVLGVVMGAFVLCWLPFFFTYPL-VVVCKTCGVPELLFKFFFWLGYCNSALNPVIYTIF 253
7tmA_P2Y3-like cd16001
P2Y purinoceptor 3-like proteins, member of the class A family of seven-transmembrane G ...
126-412 1.03e-09

P2Y purinoceptor 3-like proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y3-like proteins are an uncharacterized group that belongs to the G(i) class of a family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320667 [Multi-domain]  Cd Length: 284  Bit Score: 59.77  E-value: 1.03e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 126 AVMALFSLLGNLLTIWNIYktrisRRNSRHTWSAIYslMFHLSIADVLVTWFCIIGEAAWCYTVQWLANELTCKLVKLFQ 205
Cdd:cd16001    8 SVVFVLGLPLNGTVLWLSW-----CRTKRWTCSTIY--LVNLAVADLLYVCSLPLLIVNYAMRDRWPFGDFLCKLVRFLF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 206 MFSLYLSTYVLVLIGVDRWIAVKYPMKSLNMAKRCHRLLGG--TYILSLVLSLPQFFIFHVARGPFVEEFYQCVTHGFYT 283
Cdd:cd16001   81 YTNLYGSILFLTCISVHRFLGVCYPIRSLAYRTRRLAVIGSaaTWILVVLQLLPTLVYARTGSINNRTVCYDLTSPDNFG 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 284 ADWQEQMYATFTlvfTFLLPLCILFGTYMSTFRTISSSEKMFQGSKlanystaklptqtnrqrlihKAKMKSLRISVVII 363
Cdd:cd16001  161 NYFPYGMVLTVT---GFLIPFLIILLCYCLMIKSLIRSEEAAGVGK--------------------AARAKSIRTILLVC 217
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 442631927 364 IAFLICWTPYYVMMIMFMF----LNPDKRLgddLQDAIFFFGM------SNSLVNPLIY 412
Cdd:cd16001  218 GLFALCFVPFHITRTIYLFvrvyLVQDCPL---LQFVSLAYKIwrplvsFNSCINPLLY 273
7tmA_Beta1_AR cd15958
beta-1 adrenergic receptors (adrenoceptors), member of the class A family of ...
124-412 1.23e-09

beta-1 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-1 adrenergic receptor (beta-1 adrenoceptor), also known as beta-1 AR, is activated by adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320624 [Multi-domain]  Cd Length: 298  Bit Score: 59.92  E-value: 1.23e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 124 VLAVMALFSLLGNLLTIWNIYKTRisrRNSRHTWSAIYSLmfhlSIADVLVTWFCIIGEAAWCYTVQWLANELTCKLVKL 203
Cdd:cd15958    6 LMALIVLLIVAGNVLVIVAIGRTQ---RLQTLTNLFITSL----ACADLVMGLLVVPFGATLVVRGRWLYGSFFCELWTS 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 204 FQMFSLYLSTYVLVLIGVDRWIAVKYPMK--SLNMAKRCHRLLGGTYILSLVLS-LPQFFIFHVARGPFVEEFYQ---CV 277
Cdd:cd15958   79 VDVLCVTASIETLCVIAIDRYLAITSPFRyqSLLTRARAKGIVCTVWAISALVSfLPIMMHWWRDEDDQALKCYEdpgCC 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 278 ThgFYTadwqEQMYATFTLVFTFLLPLCILFGTYMSTFR-------TISSSEKMFQGSKLANYSTAKlptqTNRQRLIHK 350
Cdd:cd15958  159 D--FVT----NRAYAIASSIISFYIPLLIMIFVYLRVYReakkqikKIDKCEGRFHNTLTGLGRKCK----RRPSRILAL 228
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 442631927 351 AKMKSLRISVVIIIAFLICWTPYYVMMIMFMF---LNPDKrlgddLQDAIFFFGMSNSLVNPLIY 412
Cdd:cd15958  229 REQKALKTLGIIMGVFTLCWLPFFLVNVVNVFnreLVPDW-----LFVFFNWLGYANSAFNPIIY 288
7tmA_SUCNR1_GPR91 cd15378
succinate receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
157-376 1.31e-09

succinate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Succinate receptor (SUCNR1) GPR91 exclusively couples to G(i) protein to inhibit cAMP production and also activates PLC-beta to increase intracellular calcium concentrations in an inositol phosphate dependent mechanism. Succinate, an intermediate molecule of the citric cycle, is shown to cause cardiac hypertrophy via GPR91 activation. Furthermore, succinate-induced GPR91 activation is involved in the regulation of renin-angiotensin system and is suggested to play an important role in the development of renovascular hypertension and diabetic nephropathy. SUCNR1 belongs to the class A GPCR superfamily and is phylogenetically related to the purinergic P2Y1-like receptor subfamily, whose members are coupled to G(q) protein to activate phospholipase C (PLC).


Pssm-ID: 320500 [Multi-domain]  Cd Length: 283  Bit Score: 59.73  E-value: 1.31e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 157 WSAIYSLMFHLSIADVLvtWFCIIGEAAWCYTV-QWLANELTCKLVKLFQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLN 235
Cdd:cd15378   32 WKSSNIYLFNLSVSDLA--FLCTLPMLVYSYSNgQWLFGDFLCKSNRYLLHANLYSSILFLTFISIDRYLLIKYPFREHI 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 236 MAKRCHRLL--GGTYILSLVLSLPQFFIFhvarGP-FVEEFYQCVTHGFYTADWQEQMYATFTLVFTFLLPLCILFGTYm 312
Cdd:cd15378  110 LQKKRSAVAisLAIWVLVTLELLPILTFI----GPnLKDNVTKCKDYASSGDATNSLIYSLFLTVTGFLIPLCVMCFFY- 184
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 442631927 313 stfrtisssekmfqgsklanYSTAKLPTQTNRQRLIHKAKMKSLRISVVIIIAFLICWTPYYVM 376
Cdd:cd15378  185 --------------------YKIALFLKNRNRQLANATSFEKPLTLVILAVVIFSVLFTPYHVM 228
7tmA_Histamine_H1R cd15050
histamine subtype H1 receptor, member of the class A family of seven-transmembrane G ...
122-412 2.03e-09

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H1R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). H1R selectively interacts with the G(q)-type G protein that activates phospholipase C and the phosphatidylinositol pathway. Antihistamines, a widely used anti-allergy medication, act on the H1 subtype and produce drowsiness as a side effect. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320178 [Multi-domain]  Cd Length: 263  Bit Score: 58.98  E-value: 2.03e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 122 VYVLAVMALFSLLGNLLTIwniYKTRISRRnsRHTWSAIYSLmfHLSIADVLVTWFCIIGEAAWCYTVQWLANELTCKLV 201
Cdd:cd15050    4 GIALSTISLITVILNLLVL---YAVRTERK--LHTVGNLYIV--SLSVADLIVGAVVMPLNIVYLLESKWILGRPVCLFW 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 202 KLFQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLN--MAKRCHRLLGGTYILSLVLSLPQFFIFHVAR-GPFVEEFYQCVT 278
Cdd:cd15050   77 LSMDYVASTASIFSLFILCIDRYRSVQQPLKYLKyrTKTRASLMISGAWLLSFLWVIPILGWHHFARgGERVVLEDKCET 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 279 HgFYTADWqeqmYATFTLVFTFLLPLCILFGTYMSTFRTIsssekmfqgsklanystaklptqtNRQRlihkakmKSLRI 358
Cdd:cd15050  157 D-FHDVTW----FKVLTAILNFYIPSLLMLWFYAKIFKAV------------------------NRER-------KAAKQ 200
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 442631927 359 SVVIIIAFLICWTPYYVMMiMFMFLNPDKRlGDDLQDAIFFFGMSNSLVNPLIY 412
Cdd:cd15050  201 LGFIMAAFILCWIPYFILF-MVIAFCKNCC-NENLHMFTIWLGYINSTLNPFIY 252
7tmA_GPR132_G2A cd15364
proton-sensing G protein-coupled receptor 132, member of the class A family of ...
119-412 2.05e-09

proton-sensing G protein-coupled receptor 132, member of the class A family of seven-transmembrane G protein-coupled receptors; The G2 accumulation receptor (G2A, also known as GPR132) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. G2A was originally identified as a stress-inducible receptor that causes the cell cycle arrest at G2/M phase when serum is deprived. Lysophosphatidylcholine was identified as a ligand for G2A, and whose overexpression was shown to induce cell proliferation, oncogenic transformation, and apoptosis.


Pssm-ID: 320486 [Multi-domain]  Cd Length: 279  Bit Score: 59.02  E-value: 2.05e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 119 LLKVYVLAVMALfSLLGNLLTIWNIYKtRISRRNSRhtwsAIYslMFHLSIADVLVTWFCIIgeaaWCYTVQ----WLAN 194
Cdd:cd15364    2 FLVVVYSVVFAL-GFPANCLTLWLTLL-QVRRKNVL----AVY--LFSLSLCELLYLGTLPL----WTIYVSnnhkWPWG 69
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 195 ELTCKLVKLFQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLNM-AKRCHRLLggTYILSLVLSLPQFFIFHVARGPfVEEF 273
Cdd:cd15364   70 SLACKITGYIFFCNIYISILLLCCISIDRFVAVVYALESRGRrRQRIAAFI--SFLIFIVVGLVHSPVFIMREGQ-TEGS 146
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 274 YQCvthgFYTADWQEQM----YATFTLvfTFLLPLCILFGTYMSTFRTISSSEKMfqgsklanystaklptqTNRQrlih 349
Cdd:cd15364  147 HTC----FETLQMDTQVagfyYARFCI--GFAIPLAILIFTNYRIFRSIQTSTSL-----------------TPHQ---- 199
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 442631927 350 KAKMKSLRISVVIIiaFLICWTPYYVMMIM---FMFLNPDKRLGDDLQ----DAIFF-FGMSNSLVNPLIY 412
Cdd:cd15364  200 KAKVKYLAIAVIVI--FLICFAPYHLVLLVraiAFSLYPNGMCGFEERiytpSVIFLcLSTVNSVADPIIY 268
7tmA_P2Y-like cd15922
P2Y purinoceptor-like proteins, member of the class A family of seven-transmembrane G ...
124-412 2.07e-09

P2Y purinoceptor-like proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y-like proteins are an uncharacterized group that is phylogenetically related to a family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320588 [Multi-domain]  Cd Length: 284  Bit Score: 58.95  E-value: 2.07e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 124 VLAVMALFSLLGNLLTIWnIYKTRISRrnsrhtWSAIYSLMFHLSIADVLVTWFCIIGEAAWCYTVQWLANELTCKLVKL 203
Cdd:cd15922    6 FLSLVFLGGFLLNSFSLW-IFWFRIKQ------WSSGTILQFNLALSDAIITPAAPLLIAYFSLGSHWPFGQFLCQLKVF 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 204 FQMFSLYLSTYVLVLIGVDRWIA-VKYPMKSLNMAKRCHR-LLGGTYILSLVLSLPQFFifhVARGPFVEEFYQCVThgF 281
Cdd:cd15922   79 LLSTHMYGSIYFLMLISIHRYVTvVHYNWKSLWKKKSFMKkLCLGVWLLLFVQGLPFFF---VLKTSVIDGKTKCLS--I 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 282 YTADWQEQ--MYATFTLVFTFLLPlcilFGTYMSTFRTISSSekmfqgsklanysTAKLPTQTNRQRlihKAKMKSLRIS 359
Cdd:cd15922  154 HQSELSLLyfVWNFVLLILGFLLP----FGVSLTCYALLGAS-------------IAKMNSNNARGR---AMKAKSLQMI 213
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 360 VVIIIAFLICWTPYYVM----MIMFMFLNPDKRLGDDLQDAIFF---FGMSNSLVNPLIY 412
Cdd:cd15922  214 GISLVIFIICFVPLHVTrtvgVVVKLFYPESCTLLHKVEVAYYIswvLTGVNCCLDPLLY 273
7tmA_XCR1 cd15182
XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
123-412 2.10e-09

XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; XCR1 is a chemokine receptor specific for XCL1 and XCL2 (previously called lymphotactin alpha/beta), which differ in only two amino acids. XCL1/2 is the only member of the C chemokine subfamily, which is unique as containing only two of the four cysteines that are found in other chemokine families. Human XCL1/2 has been shown to be secreted by activated CD8+ T cells and upon activation of the innate immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 341337 [Multi-domain]  Cd Length: 271  Bit Score: 58.91  E-value: 2.10e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 123 YVLAVmaLFSLLGNLLTIWNIYKTRisrrnSRHTWSAIYSLmfHLSIADVLVTwfCIIGEAAWCYTVQWLANELTCKLVK 202
Cdd:cd15182    7 YYLVF--LLSLLGNGLVLWILVKYE-----KLKTLTNIFIL--NLAISDLLFT--FTLPFWASYHSSGWIFGEILCKAVT 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 203 LFQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLNMAK-RCHRLLG-GTYILSLVLSLPQFFIFHVARGPfvEEFYQCVthg 280
Cdd:cd15182   76 SIFYIGFYSSILFLTLMTIDRYLAVVHPLSALRSRKlRYASLVSvAVWVISILASLPELILSTVMKSD--EDGSLCE--- 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 281 fYTaDWQEQMYATFTLVFTFLLPLCILFGTYMSTFRTISSSEKMfqgsklanystaklptqtnrqrlihkAKMKSLRISV 360
Cdd:cd15182  151 -YS-SIKWKLGYYYQQNLFFLIPLGIIVYCYVRILQTLMRTRTM--------------------------RKHRTVKLIF 202
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 361 VIIIAFLICWTPYYVmmIMFMFLNPDKRLG-----DDLQDAIFF---FGMSNSLVNPLIY 412
Cdd:cd15182  203 VIVLVFFLSWAPYNI--VIFLRSLKDLTIPicecsKQLDYAFYIcrnIAFSHCCLNPVFY 260
7tmA_RNL3R cd14976
relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G ...
124-412 2.11e-09

relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This G protein-coupled receptor subfamily is composed of the relaxin-3 like peptide receptors, RNL3R1 and RNL3R2, and similar proteins. The relaxin-3 like peptide family includes relaxin-1, -2, -3, as well as insulin-like (INSL) peptides 3 to 6. RNL3/relaxin-3 and INSL5 are the endogenous ligands for RNL3R1 and RNL3R2, respectively. RNL3R1, also called GPCR135 or RXFP3, is predominantly expressed in the brain and is implicated in stress, anxiety, feeding, and metabolism. Insulin-like peptide 5 (INSL5), the endogenous ligand for RNL3R2 (also called GPCR142 or RXFP4), plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. Both RNL3R1 and RNL3R2 signal through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation. RNL3R1 is shown to activate Erk1/2 signaling pathway.


Pssm-ID: 320107 [Multi-domain]  Cd Length: 290  Bit Score: 59.05  E-value: 2.11e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 124 VLAVMALFSLLGNLLTIWNIYKTRisrrnSRHTWSAIYSLMFHLSIADVLVTWFCIIGEAAWCYTVQWLANELTCKLVKL 203
Cdd:cd14976    6 VYMVVFTVGLLGNLLVLYLLKSNK-----KLRQQSESNKFVFNLALTDLIFVLTLPFWAVEYALDFVWPFGTAMCKVVRY 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 204 FQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLNmakrcHRLLGGTYIL-------SLVLSLPQfFIFHVARGPFVEEFYQC 276
Cdd:cd14976   81 VTKLNMYSSIFFLTALSVTRYIAVARALKHGW-----IRKAFGAFATtiaiwaaAALAAIPE-AIFSTDTWSSVNHTLCL 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 277 VT--HGFYTADWQE--QMYATFTLVFTFLLPLCILFGTYMSTFRTISSSekmfqgsklanystaklpTQTNRQRlihkaK 352
Cdd:cd14976  155 LRfpKNSSVTRWYNwlGMYQLQKVVLGFFLPLGIITLSYLLLLRFLQRK------------------RGGSKRR-----K 211
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 442631927 353 MKSLRISVVIIIAFLICWTPYYVMMIMFMFLNPDKRLGDDLQDAIFFFGM--------SNSLVNPLIY 412
Cdd:cd14976  212 SRVTKSVFIVVLSFFICWLPNQALSLWSALIKFDDVPFSDAFFAFQTYAFpvaiclahSNSCLNPVLY 279
7tmA_mAChR_DM1-like cd15301
muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G ...
119-412 2.51e-09

muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes muscarinic acetylcholine receptor DM1-like from invertebrates. Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320428 [Multi-domain]  Cd Length: 270  Bit Score: 58.68  E-value: 2.51e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 119 LLKVYVLAVMALFSLLGNLLTIwniyktrISRRNSRHTWSAIYSLMFHLSIADVLVTwfCIIGEAAWCYTV--QWLANEL 196
Cdd:cd15301    1 VLIVIVAAVLSLVTVGGNVMVM-------ISFKIDKQLQTISNYFLFSLAVADFAIG--VISMPLFTVYTAlgYWPLGYE 71
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 197 TCKLVKLFQMFSLYLSTYVLVLIGVDRWIAVKYPM--KSLNMAKRCHRLLGGTYILSLVLSLPQFFIFHVARGPFVEEFY 274
Cdd:cd15301   72 VCDTWLAIDYLASNASVLNLLIISFDRYFSVTRPLtyRARRTTKKAAVMIASAWIISLLLWPPWIYSWPYIEGKRTVPAG 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 275 QCVTHGFYTadwqeQMYATF-TLVFTFLLPLCILFGTYMSTFRTISSSEKmfqgsklanystaklptqtnrqrlihKAKM 353
Cdd:cd15301  152 TCYIQFLET-----NPYVTFgTALAAFYVPVTIMCILYWRIWRETKKRQK--------------------------KQES 200
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 442631927 354 KSLRISVVIIIAFLICWTPYYVMMIMFMFLNPDKRLGDDLQDAIFFFGMSNSLVNPLIY 412
Cdd:cd15301  201 KAAKTLSAILLAFIVTWTPYNVLVLIKAFFPCSDTIPTELWDFSYYLCYINSTINPLCY 259
7tmA_GPR17 cd15161
G protein-coupled receptor 17, member of the class A family of seven-transmembrane G ...
119-397 2.63e-09

G protein-coupled receptor 17, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR17 is a Forkhead box protein O1 (FOXO1) target and abundantly expressed in agouti-related peptide (AGRP) neurons. FOXO1 is a transcription factor that plays key roles in regulation of gluconeogenesis and glycogenolysis by insulin signaling. For instance, food intake and body weight increase when hypothalamic FOXO1 is activated, whereas they both decrease when FOXO1 is inhibited. However, a recent study has been reported that GPR17 deficiency in mice did not affect food intake or glucose homeostasis. Thus, GPR17 may not play a role in the control of food intake, body weight, or glycemic control. GPR17 is phylogenetically closely related to purinergic P2Y and cysteinyl-leukotriene receptors.


Pssm-ID: 320289 [Multi-domain]  Cd Length: 277  Bit Score: 58.57  E-value: 2.63e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 119 LLKVYVLAVMALfSLLGNLLTIWniyktRISRRNSRHTWSAIYsLMfHLSIAD---VLVTWFCIIGEAAWCytvQWLANE 195
Cdd:cd15161    2 LFALFYILVFIL-AFPGNTLALW-----LFIHDRKSGTPSNVF-LM-HLAVADlsyVLILPMRLVYHLSGN---HWPFGE 70
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 196 LTCKLVKLFQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLNMAKRCHrllggTYILSLVLslpqFFIFHVARGPFVeefyq 275
Cdd:cd15161   71 VPCRLAGFLFYLNMYASLYFLACISVDRFLAIVHPVKSMKIRKPLY-----AHVVCGFL----WVIVTVAMAPLL----- 136
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 276 cVTHGfyTADWQ-----EQMY-------ATFTLVFTFLLPLCILFGTYMSTFRtissseKMFQGSKLANystaklptqtn 343
Cdd:cd15161  137 -VSPQ--TVEVNnttvcLQLYrekasrgALVSLAVAFTIPFVTTVTCYLLIIR------SLRTGKREEK----------- 196
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 442631927 344 rqrlihKAKMKSLRISVVIIIAFLICWTPYYVMMIMFMFLNPDKRLGDDLQDAI 397
Cdd:cd15161  197 ------PLKDKAIKMIILVLTIFLICFVPYHISRYIYILSHNGAGASCSSRRGL 244
7tmA_5-HT1A_vertebrates cd15330
serotonin receptor subtype 1A from vertebrates, member of the class A family of ...
163-416 2.76e-09

serotonin receptor subtype 1A from vertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320453 [Multi-domain]  Cd Length: 260  Bit Score: 58.45  E-value: 2.76e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 163 LMFHLSIADVLVTWFCIIGEAAWCYTVQWLANELTCKLVKLFQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLN--MAKRC 240
Cdd:cd15330   38 LIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNkrTPRRA 117
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 241 HRLLGGTYILSLVLSLPQFFIFHVARGPFVEEFYQCVTHGFYTadwqeqMYATFTlvfTFLLPLCILFGTYMSTFRTISs 320
Cdd:cd15330  118 AVLISLTWLIGFSISIPPMLGWRTPEDRSDPDACTISKDPGYT------IYSTFG---AFYIPLILMLVLYGRIFKAAA- 187
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 321 sekmfqgsklanystaklptqtnRQRlihkakmKSLRISVVIIIAFLICWTPYYVMMIMFMFLNPDKRLGDDLQDAIFFF 400
Cdd:cd15330  188 -----------------------RER-------KTVKTLGIIMGTFILCWLPFFIVALVLPFCESTCHMPELLGAIINWL 237
                        250
                 ....*....|....*.
gi 442631927 401 GMSNSLVNPLIYGAFH 416
Cdd:cd15330  238 GYSNSLLNPIIYAYFN 253
7tmA_NPFFR1 cd15981
neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G ...
130-416 2.88e-09

neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320647 [Multi-domain]  Cd Length: 299  Bit Score: 58.68  E-value: 2.88e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 130 LFSLLGNLLTIWNIYKTRisrrnSRHTWSAIYSLmfHLSIADVLVTWFCIIGEAAWCYTVQWLANELTCKLVKLFQMFSL 209
Cdd:cd15981   12 LLCMVGNGLVCFIVLKNR-----QMRTVTNMFIL--NLAVSDLLVGIFCMPTTLVDNLITGWPFDNAMCKMSGLVQGMSV 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 210 YLSTYVLVLIGVDRWIAVKYPMKSLNMAKRCHRLLGGTYILSLVLSLPQFFIFHVARgpfvEEFYQCV-----THGFYTA 284
Cdd:cd15981   85 SASVFTLVAIAVERFRCIVHPFRQKLTLRKAIVTIVIIWVLALIIMCPSAVTLTVTR----EEHHFMVddynnSYPLYSC 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 285 --DWQEQ----MYATFTLVFTFLLPLCILFGTYMSTFRtissseKMFQGSKLANYSTAklptQTNRQRLIHKAKMKSLRI 358
Cdd:cd15981  161 weAWPDTemrkIYTTVLFSHIYLAPLTLIVIMYARIAF------KLFKSSAPIRGSQG----EEEEGRRVSKRKIKVINM 230
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 442631927 359 SVVIIIAFLICWTPYYVMMIMFMFLNPDKRLGDDLQDAIFFF----GMSNSLVNPLIYGAFH 416
Cdd:cd15981  231 LIIVALFFTLSWLPLWTLMLLTDYGHLSEDQLNLVTVYVFPFahwlAFFNSSVNPIIYGYFN 292
7tmA_mAChR_M2 cd15297
muscarinic acetylcholine receptor subtype M2, member of the class A family of ...
119-412 2.92e-09

muscarinic acetylcholine receptor subtype M2, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of M2 receptor causes a decrease in cAMP production, generally leading to inhibitory-type effects. This causes an outward current of potassium in the heart, resulting in a decreased heart rate. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320424 [Multi-domain]  Cd Length: 262  Bit Score: 58.44  E-value: 2.92e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 119 LLKVYVLAVMALFSLLGNLLTIWNIyktrisrRNSRHTWSAIYSLMFHLSIADVLVTWFCIIGEAAWCYTVQWLANELTC 198
Cdd:cd15297    1 VFIVLVAGSLSLVTIIGNILVMVSI-------KVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVC 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 199 KLVKLFQMFSLYLSTYVLVLIGVDRWIAVKYPMKSlnMAKRCHRLLG----GTYILSLVLSLPQFFIFHVARGPFVEEFY 274
Cdd:cd15297   74 DLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTY--PVKRTTKMAGmmiaAAWVLSFILWAPAILFWQFIVGGRTVPEG 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 275 QCVTHGFYTAdwqeqmYATF-TLVFTFLLPLCILFGTYMSTFRTiSSSEKmfqgsklanystaklptqtnrqrlihkakm 353
Cdd:cd15297  152 ECYIQFFSNA------AVTFgTAIAAFYLPVIIMTVLYWQISRA-SSREK------------------------------ 194
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 442631927 354 KSLRISVVIIIAFLICWTPYYVMMIMFMFLNPdkrlgdDLQDAIFFFG----MSNSLVNPLIY 412
Cdd:cd15297  195 KVTRTILAILLAFIITWTPYNVMVLINTFCAS------CIPNTVWTIGywlcYINSTINPACY 251
7tmA_EBI2 cd15159
Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G ...
127-412 3.15e-09

Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Epstein-Barr virus-induced G-protein coupled receptor 2 (EBI2), also called GPR183, is activated by 7alpha, 25-dihydroxyxcholesterol (7alpha, 25-OHC), an oxysterol. EBI2 was originally identified as one of major genes induced in the Burkitt's lymphoma cell line BL41by EBV infection. EBI2 is involved in regulating B cell migration and responses, and is also implicated in human diseases such as type I diabetes, multiple sclerosis, and cancers.


Pssm-ID: 320287 [Multi-domain]  Cd Length: 286  Bit Score: 58.52  E-value: 3.15e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 127 VMALFSLLGNLLTIWNIYKTRiSRRNSrhtwSAIYSLmfHLSIADVLvtwFCIIGEAAWCYTVQ---WLANELTCKLVKL 203
Cdd:cd15159    9 LILVFGLLGNTLALHVICQKR-KKINS----TTLYLI--NLAVSDIL---FTLALPGRIAYYALgfdWPFGDWLCRLTAL 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 204 FQMFSLYLSTYVLVLIGVDRWIAVKYPMK--SLNMAKRCHRLLGGTYILSLVLSLPQFFIfhvargPFVEEFYQCVTHGF 281
Cdd:cd15159   79 LFYINTYAGVNFMTCLSVDRYIAVVHPLRrhRLRKVKVVRYICVFVWVLVFLQTLPLLFM------PMTKEMGGRITCME 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 282 YtADWQEQMYATFTLVFTFLLPLCILFGTYMSTFRTISSseKMFQGSKlANystaKLPTQTNRQRlihkakmKSLRISVV 361
Cdd:cd15159  153 Y-PNFEKIKRLPLILLGACVIGFGVPVGIILFCYSQITL--KLCRTAK-EN----PLTEKSGHHK-------KACNVILL 217
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 442631927 362 IIIAFLICWTPYYVMMIMFM----FLNPD----KRLGDDLQDAIFFFGMsNSLVNPLIY 412
Cdd:cd15159  218 VLLVFVVCFSPYHLNIIQFMirklLYQPScselKAFKISLQITVCLMNL-NCCLDPFIY 275
7tmA_D4_dopamine_R cd15308
D4 dopamine receptor of the D2-like family, member of the class A family of ...
191-416 3.48e-09

D4 dopamine receptor of the D2-like family, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320434 [Multi-domain]  Cd Length: 258  Bit Score: 57.92  E-value: 3.48e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 191 WLANELTCKLVKLFQMFSLYLSTYVLVLIGVDRWIAVKYPMKsLNMAKRCHR---LLGGTYILSLVLSLPQFFIFHVARG 267
Cdd:cd15308   67 WTLSPVLCDALMTMDVMLCTASIFNLCAISVDRFIAVSVPLN-YNRRQGSVRqllLISATWILSFAVASPVIFGLNNVPN 145
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 268 --PFVEEFyqcvthgfytadwQEQMYATFTLVFTFLLPLCILFGTYMSTFRTISssekmfqgsklanystaklptqtnRQ 345
Cdd:cd15308  146 rdPAVCKL-------------EDNNYVVYSSVCSFFIPCPVMLVLYCAMFRGLG------------------------RE 188
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 442631927 346 RlihkakmKSLRISVVIIIAFLICWTPYYVMMIMfMFLNPDKRLGDDLQDAIFFFGMSNSLVNPLIYGAFH 416
Cdd:cd15308  189 R-------KAMRVLPVVVGAFLFCWTPFFVVHIT-RALCESCSIPPQLISIVTWLGYVNSALNPVIYTVFN 251
7tmA_HCAR1-3 cd15201
hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G ...
124-412 3.73e-09

hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Hydroxycarboxylic acid receptor (HCAR) subfamily, a member of the class A G-protein coupled receptors (GPCRs), contains three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, or nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2 or GPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. Because nicotinic acid is capable of stimulating HCAR2 at higher concentrations only (in the range of sub-micromolar concentration), it is unlikely that nicotinic acts as a physiological ligand of HCAR2. All three receptors are expressed in adipocytes and mediate anti-lipolytic effects in fat cells through G(i) type G protein-dependent inhibition of adenylate cyclase.


Pssm-ID: 320329 [Multi-domain]  Cd Length: 281  Bit Score: 58.14  E-value: 3.73e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 124 VLAVMALFSLLGNLLTIWnIYKTRisrrnsRHTWSAIYSLMFHLSIADVLVTwFCIIGEAAWcYT--VQWLANELTCKLV 201
Cdd:cd15201    6 VLILEFVLGLLGNGLALW-IFCFH------LKSWKSSTVYLFNLAVADFLLI-ICLPFRTDY-YLrgKHWKFGDIPCRIV 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 202 kLFqMFSLYL--STYVLVLIGVDRWIAVKYPMKSLN-MAKRCHRLL-GGTYILSL-----VLSLPQFFIFHVARgpFVEE 272
Cdd:cd15201   77 -LF-MLAMNRagSIFFLTAVAVDRYFRVVHPHHRINsISVRKAAIIaCGLWLLTIamtvyLLTKKHLFPRGNAT--QCES 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 273 FYQCVTHGfYTADWQEQMYatftlVFTFLLPLCILFgtymstfrtisssekmfqgsklanYSTAKLPTQTNRQRLIHKAK 352
Cdd:cd15201  153 FNICTGTD-SSSNWHEAMF-----LLEFFLPLAIIL------------------------YCSVRIIWQLRGRQLDRHAK 202
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 353 MK-SLRISVVIIIAFLICWTPYYVMMIMFMFLNPdkRLGDDLQ-----DAIFFFGMS----NSLVNPLIY 412
Cdd:cd15201  203 IKrAVQFIMVVAIVFIICFLPSNVTRIAIWILKH--TSNEDCQyyrsvDLAFYITISftyfNSMLDPVVY 270
7tmA_GPR87 cd15969
G protein-coupled receptor 87, member of the class A family of seven-transmembrane G ...
127-418 3.92e-09

G protein-coupled receptor 87, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR87 acts as one of multiple receptors for lysophosphatidic acid (LPA). This orphan receptor has been shown to be over-expressed in several malignant tumors including lung squamous cell carcinoma and regulated by p53. GPR87 is phylogenetically closely related to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase.


Pssm-ID: 320635 [Multi-domain]  Cd Length: 283  Bit Score: 58.26  E-value: 3.92e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 127 VMALFSLLGNLLTIWNIYKTRISRrnsrhtwSAIYSLMfHLSIADVLVTW---FCIIGEAAWCytvQWLANELTCKLVKL 203
Cdd:cd15969    9 IIFIGSILLNGLAVWIFFHIRNKT-------SFIFYLK-NIVIADLLMTLtfpFKIIQDSGLG---PWNFNFFLCRYTSV 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 204 FQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLNMAK----RChrLLGGTYILSLVLSLPQffIFHVARGPFVEEFYQCVT- 278
Cdd:cd15969   78 LFYASMYTSIVFLGLISLDRYLKVVKPFGDSRMYSitftKV--LSACVWLIMAFLSLPN--IILTNGQPTEDNIHDCSKl 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 279 HGFYTADWQEQMyaTFTLVFTFLLPLCILFGTYMSTFRTISSSEKMFQgsklanystaklpTQTNRQRlihkAKMKSLRi 358
Cdd:cd15969  154 KSPLGVKWHTAV--SYINICIFVAVLVILIVCYISISRYIYKSSKQFI-------------SSSSRTR----KHNQSIR- 213
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 442631927 359 svVIIIAFLICWTPYYVMMIMFMFLNPDKRLGDDLQ-------DAIFFFGMSNSLVNPLIYgaFHLC 418
Cdd:cd15969  214 --VVVAVFFVCFLPYHLCRIPFTFSQLDKILDCTIKtilyyckEATLFLSACNVCLDPIIY--FFMC 276
7tmA_BNGR-A34-like cd15000
putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of ...
120-413 4.19e-09

putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor BNGR-A34 found in silkworm and its closely related proteins from invertebrates. They are members of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320131 [Multi-domain]  Cd Length: 285  Bit Score: 58.21  E-value: 4.19e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 120 LKVYVLAVMALFSLLGNLLTIWNIYKtrisrrnSRHTWSAIYSLMFHLSIADVLVTWFCIIGEAAWCYTVQWLANELTCK 199
Cdd:cd15000    1 IKSSMFLPVVLFGIFGNFVLLYILAS-------NRSLRTPTNLLIGNMALADLLTLLVCPWMFLVHDFFQNYVLGSVGCK 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 200 LVKLFQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLNMAKRCHRLLGGTYILSLVLSLPqFFIFHvargPFVEEFYQCVTH 279
Cdd:cd15000   74 LEGFLEGSLLLASVLALCAVSYDRLTAIVLPSEARLTKRGAKIVIVITWIVGLLLALP-LAIYR----SYRERQWKNFLE 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 280 GFYTADWQ-EQMYATFTLVFTFLLPLCILFGTYMSTFRTISSSEKMfqgsklanystaklpTQTNRQRLIHKAKMKSLRI 358
Cdd:cd15000  149 TYCAENTQvLPIYWHVIITVLVWLPLGIMLICYSAIFWKLDKYERR---------------VLRREHPSVVRYKKKAAKT 213
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 442631927 359 SVVIIIAFLICWTPYYVMMI----MFMFLNPDKRLGDDLQDAIF---FFGMSNSLVNPLIYG 413
Cdd:cd15000  214 LFIVLITFVVCRIPFTALIFyrykLVPNDNTQNSVSGSFHILWFaskYLMFLNAAVNPLIYG 275
7tmA_NPY2R cd15399
neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G ...
130-413 5.78e-09

neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320521 [Multi-domain]  Cd Length: 285  Bit Score: 57.52  E-value: 5.78e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 130 LFSLLGNLLTIWNIYKTRISRRNSRHtwsaiysLMFHLSIADVLVTWFCIIGEAAWCYTVQWLANELTCKLVKLFQMFSL 209
Cdd:cd15399   12 LLGVVGNSLVIYVVIKFKNMRTVTNF-------FIANLAVADLMVNTLCLPFTLVYTLLDEWKFGAVLCHLVPYAQALAV 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 210 YLSTYVLVLIGVDRWIAVKYPMKSLNMAKRCHRLLGGTYILSLVLSLPQFFifhvargpFVEEFYQCVTHGFYTADWQEQ 289
Cdd:cd15399   85 HVSTVTLTVIALDRHRCIVYHLESKISKKISFLIIGLTWAASALLASPLAI--------FREYSVIEISPDFKIQACSEK 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 290 ----------MYATFTLVFTFLLPLCILFGTYMSTFrtisssekmfqgSKLANYSTaklPTQTNRQRliHKAKMKSLRIS 359
Cdd:cd15399  157 wpngtlndgtIYSVSMLLIQYVLPLAIISYAYIRIW------------TKLKNHVS---PGGGNDHY--HQRRRKTTKML 219
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 442631927 360 VVIIIAFLICWTPYYVMMIMfmfLNPDKRLGD----DLQDAIF-FFGMSNSLVNPLIYG 413
Cdd:cd15399  220 VCVVVVFAVSWLPFHAFQLA---SDIDSKVLDlkeyKLIYTIFhVIAMCSTFANPLLYG 275
7tmA_GPR68_OGR1 cd15367
G protein-coupled receptor 68, member of the class A family of seven-transmembrane G ...
191-379 6.55e-09

G protein-coupled receptor 68, member of the class A family of seven-transmembrane G protein-coupled receptors; The ovarian cancer G-protein receptor 1 (OGR1, also known as GPR68) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 receptor (TDAG8, GPR65), and the G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. Knock-out mice studies have suggested that OGR1 plays a role in the regulation of insulin secretion and glucose metabolism. OGR1 couples to G(q/11) proteins and activates phospholipase C and Ca2+ signaling pathways.


Pssm-ID: 320489 [Multi-domain]  Cd Length: 276  Bit Score: 57.47  E-value: 6.55e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 191 WLANELTCKLVKLFQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLNMAKRCHRLLGGTYILSLVLSLPQFFIFHVARGPFV 270
Cdd:cd15367   66 WTYSELLCKICGILLYENIYISIGFLCCISVDRYLAVVHPFRFHAFRTMKAATLVSTVIWLKELMTCVFFFLHGEISKDK 145
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 271 EEFYQCVTHgFYTADWQEQM-YATFTLvfTFLLPLCILFGTYMSTFRTISSSekmfQGsklanystaklpTQTNRqrlih 349
Cdd:cd15367  146 ENHSVCFEH-YPIKAWEHNInYYRFYA--GFLFPIFLLSFSYCRILRAVRKS----HG------------TQKSQ----- 201
                        170       180       190
                 ....*....|....*....|....*....|
gi 442631927 350 KAKMKSLRISVVIIiaFLICWTPYYVMMIM 379
Cdd:cd15367  202 KIQIKRLVLSTVVI--FLVCFGPYHILLLV 229
7tmA_Adenosine_R_A2B cd15069
adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...
127-412 1.36e-08

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320197 [Multi-domain]  Cd Length: 294  Bit Score: 56.48  E-value: 1.36e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 127 VMALFSLLGNLLTIWNIYKTRISRRNSRHtwsaiysLMFHLSIADVLVTWFCIigEAAWCYTVQWLANELTCKLVKLFQM 206
Cdd:cd15069    9 IIAALSVAGNVLVCAAVGTNSTLQTPTNY-------FLVSLAAADVAVGLFAI--PFAITISLGFCTDFHSCLFLACFVL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 207 FSLYLSTYVLVLIGVDRWIAVKYPM--KSLNMAKRCHRLLGGTYILSLVLSLPQFFIFHVARG--PFVEEFYQCVT--HG 280
Cdd:cd15069   80 VLTQSSIFSLLAVAVDRYLAIKVPLryKSLVTGKRARGVIAVLWVLAFGIGLTPFLGWNKAMSatNNSTNPADHGTnhSC 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 281 -FYTADWQEQMYATFTLVFTF----LLPLCILFGTYMSTFRTISsseKMFQGSKLANYStaklptQTNRQRLIHKAKmks 355
Cdd:cd15069  160 cLISCLFENVVPMSYMVYFNFfgcvLPPLLIMLVIYIKIFLVAC---RQLQRTELMDHS------RTTLQREIHAAK--- 227
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 442631927 356 lriSVVIIIA-FLICWTPYYVMMIMFMFLNPDKRLGDD-LQDAIFFFGMSNSLVNPLIY 412
Cdd:cd15069  228 ---SLAIIVGiFALCWLPVHILNCITLFQPEFSKSKPKwAMNVAILLSHANSVVNPIVY 283
7tmA_P2Y1-like cd15967
P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically ...
133-412 1.49e-08

P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically related to a family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320633 [Multi-domain]  Cd Length: 281  Bit Score: 56.24  E-value: 1.49e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 133 LLGNLLTIWniyktriSRRNSRHTWSAIYSLMFHLSIADVLVTW---FCIIGEAAwcyTVQWLANELTCKLVKLFQMFSL 209
Cdd:cd15967   15 LVGNVWGLK-------SLLANWKKLGNINVFVLNLGLADLLYLLtlpFLVVYYLK---GRKWIFGQVFCKITRFCFNLNL 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 210 YLSTYVLVLIGVDRWIAVKYPMKSLNMAKRCHRLL--GGTYILSLVLSLPQFFIFHVARGPfveefYQCV--THGFYTAD 285
Cdd:cd15967   85 YGSIGFLTCISVYRYLAIVHPMRVMGRITTTHSVVisALVWLLVVIQSLPDLFFSKTNSNG-----TKCFdtTFNDYLES 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 286 wqeqmYATFTLVFT---FLLPLCILFGTYMSTFRTISSSEKMFQGsklanystaklptqtnrqrlihkAKMKSLRISVVI 362
Cdd:cd15967  160 -----YLTYSLGWTvtgFVIPLLIILGCYGHVVVVLCRNNNVDKG-----------------------LKQRCLKLVIIL 211
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 442631927 363 IIAFLICWTPYYVmmimFMFLNPDKRLgddLQ---------DAIFFF-----GMS--NSLVNPLIY 412
Cdd:cd15967  212 IVLFSVCYIPYHV----FRNLNLLSRI---LQkqgsctqwfRGIYIAhqvsrGLVclNSALNPLVY 270
7tmA_5-HT5 cd15328
serotonin receptor subtype 5, member of the class A family of seven-transmembrane G ...
119-416 1.51e-08

serotonin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; 5-HT5 receptor, one of 14 mammalian 5-HT receptors, is activated by the neurotransmitter and peripheral signal mediator serotonin (also known as 5-hydroxytryptamine or 5-HT). The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/0) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320451 [Multi-domain]  Cd Length: 259  Bit Score: 56.11  E-value: 1.51e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 119 LLKVYVLAVMALFSLLGNLLTIWNIYKTRISRRnsrhtwsAIYSLMFHLSIADVLVTWFCI-IGEAAWCYTVQWLANELT 197
Cdd:cd15328    1 VLVLTLLAMLVVATFLWNLLVLVTILRVRTFHR-------VPHNLVASMAVSDVLVAALVMpLSLVHELSGRRWQLGRSL 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 198 CKLVKLFQMFSLYLSTYVLVLIGVDR-WIAVKYPMKSLNMAKRCHRLL-GGTYILSLVLSL-PQFFIFHVARGPFVEEfy 274
Cdd:cd15328   74 CQVWISFDVLCCTASIWNVTAIALDRyWSITRHLEYTLRTRRRISNVMiALTWALSAVISLaPLLFGWGETYSEDSEE-- 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 275 qCVTHgfytadwQEQMYATFTLVFTFLLPLCILFGTYMStfrtisssekmfqgsklanystaklptqtnrqrlIHKAKMK 354
Cdd:cd15328  152 -CQVS-------QEPSYTVFSTFGAFYLPLCVVLFVYWK----------------------------------IYKAAQK 189
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 442631927 355 SLRISV---VIIIAFLICWTPYYVMMIMFMFLNPDkrLGDDLQDAIFFFGMSNSLVNPLIYGAFH 416
Cdd:cd15328  190 EKRAALmvgILIGVFVLCWIPFFLTELISPLCSCD--IPPIWKSIFLWLGYSNSFFNPLIYTAFN 252
7tmA_Bradykinin_R cd15189
bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
127-412 1.58e-08

bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320317 [Multi-domain]  Cd Length: 284  Bit Score: 56.32  E-value: 1.58e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 127 VMALFSLLGNL--LTIWNIYKTRIsrrnsrhTWSAIYslMFHLSIADVLVTwfciIGEAAWCYTV----QWLANELTCKL 200
Cdd:cd15189    9 SLCLFGLLGNLfvLLVFLLHRRRL-------TVAEIY--LGNLAAADLVFV----SGLPFWAMNIlnqfNWPFGELLCRV 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 201 VKLFQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLNMAKRCHRLLGGTYI--LSLVLSLPQFFIFHVArgpFVEEF--YQC 276
Cdd:cd15189   76 VNGVIKVNLYTSIYLLVMISQDRYLALVKTMAARRLRRRRYAKLICVLIwvVGLLLSIPTFLLRKIK---AIPDLniTAC 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 277 V---THGFYTADWQEQMYatftlVFTFLLPLCILFGTYMSTFRTISSSEkmfqgsklanystaklptQTNRQRLIHKAKM 353
Cdd:cd15189  153 VllyPHEAWHFAHIVLLN-----IVGFLLPLLVITFCNYNILQALRTRE------------------ESTRCEDRNDSKA 209
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 354 KSLRISVViiIAFLICWTPYYVmmimFMFLNPDKRLG--DDLQDAIF---------FFGMSNSLVNPLIY 412
Cdd:cd15189  210 TALVLAVT--LLFLVCWGPYHF----FTFLDFLFDVGvlDECFWEHFidiglqlavFLAFSNSCLNPVLY 273
PHA02638 PHA02638
CC chemokine receptor-like protein; Provisional
115-379 2.01e-08

CC chemokine receptor-like protein; Provisional


Pssm-ID: 165021 [Multi-domain]  Cd Length: 417  Bit Score: 56.95  E-value: 2.01e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 115 SRSGLLKVYVLaVMALFSLLGNLLTIWNIYKTRISrrnsrhTWSAIYslMFHLSIADVLVTW---FCIIGEAAwcytvQW 191
Cdd:PHA02638  96 SISEYIKIFYI-IIFILGLFGNAAIIMILFCKKIK------TITDIY--IFNLAISDLIFVIdfpFIIYNEFD-----QW 161
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 192 LANELTCKLVKLFQMFSLYLSTYVLVLIGVDRWIAVKYPM-----KSLNMAKrchRLLGGTYILSLVLSLPQFFIFHVAR 266
Cdd:PHA02638 162 IFGDFMCKVISASYYIGFFSNMFLITLMSIDRYFAILYPIsfqkyRTFNIGI---ILCIISWILSLIITSPAYFIFEASN 238
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 267 GPFVEE-------FYQCVThgfyTADWQEQMYATFTLVFTF-------LLPLCILFGTYMSTFRTIsssekmfqgsklan 332
Cdd:PHA02638 239 IIFSAQdsnetisNYQCTL----IEDNEKNNISFLGRILQFeinilgmFIPIIIFAFCYIKIILKL-------------- 300
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 442631927 333 ystaklptqtnrQRLIHKAKMKSLRISVVIIIAFLICWTPYYVMMIM 379
Cdd:PHA02638 301 ------------KQLKKSKKTKSIIIVSIIIICSLICWIPLNIVILF 335
7tmA_D1B_dopamine_R cd15319
D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
124-412 2.05e-08

D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320442 [Multi-domain]  Cd Length: 317  Bit Score: 56.50  E-value: 2.05e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 124 VLAVMALFSLLGNLLTIWNIYKTRISRrnSRHTWSAIYSLMFHLSIADVLVTWFCIIGEAA--W---CYTVQWLANELTC 198
Cdd:cd15319    6 LLSLLILWTLLGNILVCAAVVRFRHLR--SKVTNIFIVSLAVSDLFVALLVMPWKAVAEVAgyWpfgAFCDVWVAFDIMC 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 199 KLVKLFQmfslylstyvLVLIGVDRWIAVKYPMK-SLNMAKRCHRLL-GGTYILSLVLS-LPQFFIFHVARGPfveefYQ 275
Cdd:cd15319   84 STASILN----------LCVISVDRYWAISSPFRyERKMTQRVALVMiSVAWTLSVLISfIPVQLNWHKDSGD-----DW 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 276 CVTHGFYTADWQEQ--------MYATFTLVFTFLLPLCILFGTYMSTFRT-------ISSSEKMFQGSKLANYSTAKLPT 340
Cdd:cd15319  149 VGLHNSSISRQVEEncdsslnrTYAISSSLISFYIPVAIMIVTYTRIYRIaqiqirrISSLERAAEHAQSCRSNRIDCHH 228
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 341 QTNRQRLIHKaKMKSLRISVVIIIAFLICWTPYYVMMIMFMFLN-----PDKRL---GDDLQDAIFFFGMSNSLVNPLIY 412
Cdd:cd15319  229 HTSLRTSIKK-ETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCDrppadPDAGLpcvSETTFDVFVWFGWANSSLNPIIY 307
7tmA_MCHR2 cd15339
melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane ...
133-379 2.21e-08

melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320461 [Multi-domain]  Cd Length: 283  Bit Score: 55.98  E-value: 2.21e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 133 LLGNLLTIWNIYKTRisrrnsRHTWSAIYSLmfHLSIAD---VLVTWFCIigeAAWCYTVQWLANELTCKLVKLFQMFSL 209
Cdd:cd15339   15 LVGNILVLFTIIRSR------KKTVPDIYVC--NLAVADlvhIIVMPFLI---HQWARGGEWVFGSPLCTIITSLDTCNQ 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 210 YLSTYVLVLIGVDRWIAVKYPMKSLNMakrchRLLGGTYILSLVLSLPQFFI-FHVARGPFVEEFYQCVTHGFYTADWQE 288
Cdd:cd15339   84 FACSAIMTAMSLDRYIALVHPFRLTSL-----RTRSKTIRINLLVWAASFILvLPVWVYAKVIKFRDGLESCAFNLTSPD 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 289 QM--YATFTLVFTFLLPLCILFGTYMstfRTISSSEKMFQGSKLANYSTAKLPtqtnRQRLIHKAKMkslriSVVIIIAF 366
Cdd:cd15339  159 DVlwYTLYQTITTFFFPLPLILICYI---LILCYTWEMYRKNKKAGRYNTSIP----RQRVMRLTKM-----VLVLVGVF 226
                        250
                 ....*....|...
gi 442631927 367 LICWTPYYVMMIM 379
Cdd:cd15339  227 LVSAAPYHVIQLV 239
7tmA_NPBWR cd15087
neuropeptide B/W receptors, member of the class A family of seven-transmembrane G ...
167-415 2.36e-08

neuropeptide B/W receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide B/W receptor 1 and 2 are members of the class A G-protein coupled receptors that bind the neuropeptides B and W, respectively. NPBWR1 (previously known as GPR7) is expressed predominantly in cerebellum and frontal cortex, while NPBWR2 (previously known as GPR8) is located mostly in the frontal cortex and is present in human, but not in rat and mice. These receptors are suggested to be involved in the regulation of food intake, neuroendocrine function, and modulation of inflammatory pain, among many others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320215 [Multi-domain]  Cd Length: 282  Bit Score: 55.90  E-value: 2.36e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 167 LSIADVLVTWFCIIGEAAWCYTvQWLANELTCKLVKLFQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLNMAKRCHRLLG- 245
Cdd:cd15087   42 LAIADDLFTLVLPINIAEHLLQ-QWPFGELLCKLILSIDHYNIFSSIYFLTVMSVDRYLVVLATVRSRRMPYRTYRAAKi 120
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 246 ---GTYILSLVLSLPqFFIFHVARGPfVEEFYQCVthgfYTADWQEQMY----ATFTLVFTFLLP---LCILFGTYMSTF 315
Cdd:cd15087  121 vslCVWLLVTIIVLP-FTVFAGVYSN-ELGRKSCV----LSFPSPESLWfkasRIYTLVLGFAIPvstICILYTMMLYKL 194
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 316 RTISSSekmfqgsklanySTAKlptqtnrqrLIHKAKMKSLRISVVIIIAFLICWTPYYVMMIMfmflnpdkRLGDDLQD 395
Cdd:cd15087  195 RNMRLN------------SNAK---------ALDKAKKKVTLMVLVVLAVCLFCWTPFHLSTVV--------ALTTDLPQ 245
                        250       260
                 ....*....|....*....|....*....
gi 442631927 396 AIFFFGMS---------NSLVNPLIYgAF 415
Cdd:cd15087  246 TPLVIGISyfitslsyaNSCLNPFLY-AF 273
7tmA_LTB4R1 cd15121
leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of ...
119-379 2.69e-08

leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320249 [Multi-domain]  Cd Length: 278  Bit Score: 55.59  E-value: 2.69e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 119 LLKVYVLAVMALFSLLGNLLTIWNIYkTRISRRnsrhTWSAIysLMFHLSIAD--VLVT--WFCIIGEAAwcytvQWLAN 194
Cdd:cd15121    1 QLGIAILSLAFILGFPGNLFVVWSVL-CRMKKR----SVTCI--LVLNLALADaaVLLTapFFLHFLSGG-----GWEFG 68
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 195 ELTCKLVKLFQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLNM--AKRCHRLLGGTYILSLVLSLPQFfifhvargpfvee 272
Cdd:cd15121   69 SVVCKLCHYVCGVSMYASIFLITLMSMDRCLAVAKPFLSQKMrtKRSVRALLLAIWIVAFLLSLPMP------------- 135
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 273 FYQCVTHGF---------YTADWQEQMYATFTLVFTFLLPLCILfgtymstfrtisssekmfqgskLANYSTAKLPTQTN 343
Cdd:cd15121  136 FYRTVLKKNinmklcipyHPSVGHEAFQYLFETITGFLLPFTAI----------------------VTCYSTIGRRLRSA 193
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 442631927 344 RqrliHKAKMKSLRISVVIIIAFLICWTPYYVMMIM 379
Cdd:cd15121  194 R----FRRKRRTNRLVVLIIATFALFWLPYHVVNLI 225
7tmA_Parapinopsin cd15075
non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled ...
218-412 2.81e-08

non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the non-visual pineal pigment, parapinopsin, which is a member of the class A of the seven transmembrane G protein-coupled receptors. Parapinopsin serves as a UV-sensitive pigment for the wavelength discrimination in the pineal-related organs of lower vertebrates such as reptiles, amphibians, and fish. Although parapinopsin is phylogenetically related to vertebrate visual pigments such as rhodopsin, which releases its retinal chromophore and bleaches, the parapinopsin photoproduct is stable and does not bleach. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells.


Pssm-ID: 320203 [Multi-domain]  Cd Length: 279  Bit Score: 55.55  E-value: 2.81e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 218 LIGVDRWIAVKYPMKSLNMAKRcHRLLG--GTYILSLVLSLPQFFifhvARGPFVEE--FYQCVTHgFYTADWQEQMYAT 293
Cdd:cd15075   93 VIAVDRLFVVCKPLGTLTFQTR-HALAGiaSSWLWSLIWNTPPLF----GWGSYQLEgvMTSCAPD-WYSRDPVNVSYIL 166
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 294 FTLVFTFLLPLCILFGTYMSTFRTISSSEKMfqgsklanystaklptQTNRQRLIHKAKMKSLRISVVIIIAFLICWTPy 373
Cdd:cd15075  167 CYFSFCFAIPFAIILVSYGYLLWTLRQVAKL----------------GVAEGGSTAKAEVQVARMVVVMVMAFLLCWLP- 229
                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 442631927 374 YVMMIMFMFLNPDKRLGDDLQDAIFFFGMSNSLVNPLIY 412
Cdd:cd15075  230 YAAFALTVVSKPDVYINPLIATVPMYLAKSSTVYNPIIY 268
7tmA_motilin_R cd15132
motilin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
191-380 4.04e-08

motilin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Motilin receptor, also known as GPR38, is a G-protein coupled receptor that binds the endogenous ligand motilin. Motilin is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. Motilin is also called as the housekeeper of the gut because it is responsible for the proper filling and emptying of the gastrointestinal tract in response to food intake, and for stimulating the production of pepsin. Motilin receptor shares significant amino acid sequence identity with the growth hormone secretagogue receptor (GHSR) and neurotensin receptors (NTS-R1 and 2).


Pssm-ID: 320260 [Multi-domain]  Cd Length: 289  Bit Score: 55.19  E-value: 4.04e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 191 WLANELTCKlvklfqmFSLYLS---TYVLVL----IGVDRWIAVKYPMKS--LNMAKRCHRLLGGTYILSLVLSLPQFFI 261
Cdd:cd15132   66 WIFGEFLCR-------LYHYISegcTYATILhitaLSIERYLAICFPLRAkvLVTRRRVKCVIAALWAFALLSAGPFLFL 138
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 262 FHVARGPFVEEFY---QCVTHGFYTADWQEQMYATFTLVFTFLLPLCILFgTYMSTFRTISSSEKMFQGsklanystakl 338
Cdd:cd15132  139 VGVEQDNNIHPDDfsrECKHTPYAVSSGLLGIMIWVTTTYFFLPMLCLSF-LYGFIGRKLWKSKNDLRG----------- 206
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 442631927 339 PTQTNRQRLiHKakmKSLRISVVIIIAFLICWTPYYVMMIMF 380
Cdd:cd15132  207 PNAAARERS-HR---QTVRILAVVVLAFIICWLPFHIGRILF 244
7tmA_Beta2_AR cd15957
beta-2 adrenergic receptors (adrenoceptors), member of the class A family of ...
124-412 4.68e-08

beta-2 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; Beta-2 AR is activated by adrenaline that plays important roles in cardiac function and pulmonary physiology. While beta-1 AR and beta-2 AR are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway, beta-2 AR can couple to both G(s) and G(i) proteins in the heart. Moreover, beta-2 AR activation leads to smooth muscle relaxation and bronchodilation in the lung. The beta adrenergic receptors are a subfamily of the class A rhodopsin-like G protein-coupled receptors.


Pssm-ID: 341355 [Multi-domain]  Cd Length: 301  Bit Score: 55.25  E-value: 4.68e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 124 VLAVMALFSLLGNLLTIwniykTRISRRNSRHTWSAIYslMFHLSIADVLVTWFCIIGEAAWCYTVQWLANELTCKLVKL 203
Cdd:cd15957    6 VMSLIVLAIVFGNVLVI-----TAIAKFERLQTVTNYF--ITSLACADLVMGLAVVPFGAAHILLKTWTFGNFWCEFWTS 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 204 FQMFSLYLSTYVLVLIGVDRWIAVKYPMK--SLNMAKRCHRLLGGTYILSLVLS-LPQFFIFHVARGPFVEEFYQCVT-H 279
Cdd:cd15957   79 IDVLCVTASIETLCVIAVDRYFAITSPFKyqSLLTKNKARVIILMVWIVSGLTSfLPIQMHWYRATHQEAINCYAEETcC 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 280 GFYTadwqEQMYATFTLVFTFLLPLCILFGTYMSTF-------RTISSSEKMFqGSKLANYSTAKLPTQTNRQRLIHKAK 352
Cdd:cd15957  159 DFFT----NQAYAIASSIVSFYVPLVIMVFVYSRVFqeakrqlQKIDKSEGRF-HNQNIDQNGSGGGGGNRRRSKFCLKE 233
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 353 MKSLRISVVIIIAFLICWTPYYVMMIMFMFLNPDKRlgDDLQDAIFFFGMSNSLVNPLIY 412
Cdd:cd15957  234 HKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIR--KEVYILLNWIGYVNSGFNPLIY 291
7tmA_GRPR cd15124
gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
124-376 5.18e-08

gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The gastrin-releasing peptide receptor (GRPR) is a G-protein coupled receptor whose endogenous ligand is gastrin releasing peptide. GRP shares high sequence homology with the neuropeptide neuromedin B in the C-terminal region. This receptor is high glycosylated and couples to a pertussis-toxin-insensitive G protein of the family of Gq/11, which leads to the activation of phospholipase C. Gastrin-releasing peptide (GRP) is a potent mitogen for neoplastic tissues and involved in regulating multiple functions of the gastrointestinal and central nervous systems. These include the release of gastrointestinal hormones, the contraction of smooth muscle cells, and the proliferation of epithelial cells. GRPR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320252 [Multi-domain]  Cd Length: 293  Bit Score: 54.91  E-value: 5.18e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 124 VLAVMALFSLLGNLlTIWNIYKTRISRRNSRHTWsaiyslMFHLSIADVLVTWFCIIGEAAWCYTVQWLANELTCKLVKL 203
Cdd:cd15124    6 VYGIIILIGLIGNI-TLIKIFCTVKSMRNVPNLF------ISSLALGDLLLLVTCAPVDASRYLADEWLFGRVGCKLIPF 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 204 FQMFSLYLSTYVLVLIGVDRWIAVKYPMK---SLNMAKRCHRlLGGTYILSLVLSLPQ--FFIFHvargPFVEE-----F 273
Cdd:cd15124   79 IQLTSVGVSVFTLTALSADRYKAIVRPMDiqaSNALMKICLK-AALIWILSMLLAIPEavFSDLH----PFYDKstnktF 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 274 YQCVTHGfYTADWQEQMYATFTLVFTFLLPLCILfgtymSTFRTISSSEKMfqgsklanYSTAKLPTQTNRQRLIHKAKM 353
Cdd:cd15124  154 VSCAPYP-HSNELHPKIHSMASFLIFYVIPLSII-----SVYYYFIAKNLI--------RSAYNLPVEGNVHVRRQIESR 219
                        250       260
                 ....*....|....*....|....
gi 442631927 354 KSLRISVVIIIA-FLICWTPYYVM 376
Cdd:cd15124  220 KRLAKTVLVFVGlFAFCWLPNHII 243
7tmA_GPR1 cd15119
G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane ...
120-412 6.53e-08

G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 1 (GPR1) belongs to the class A of the seven transmembrane domain receptors. This is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1. GPR1 is most closely related to another chemerin receptor CMKLR1. In an in-vitro study, GPR1 has been shown to act as a co-receptor to allow replication of HIV viruses.


Pssm-ID: 320247 [Multi-domain]  Cd Length: 278  Bit Score: 54.36  E-value: 6.53e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 120 LKVYVLAVmaLFSLLGNLLTIWniyktrISRRNSRHTWSAIYSLmfHLSIADVLVTWFCIIGEAAWCYTVQWLANELTCK 199
Cdd:cd15119    4 IVIYIVAF--VLGVPGNAIVIW------VTGFKWKKTVNTLWFL--NLAIADFVFVLFLPLHITYVALDFHWPFGVWLCK 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 200 LVKLFQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLNMAKRCHRLL--GGTYILSLVLSLPqFFIFH---VARGPFVEEFY 274
Cdd:cd15119   74 INSFVAVLNMFASVLFLTVISLDRYISLAHPVWSHRYRTLKSALIlcGIVWLSAAAISGP-ALYFRdtmELSINVTICFN 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 275 QCVTHGFYTADWQEQMYATFTLVFTFLLPLCILFGTYmstfrtisssekmfqgsklanystAKLPTQTNRQRLIHKAKMk 354
Cdd:cd15119  153 NFHKHDGDLIVMRHTILVWVRFFFGFLFPLLTMVVCY------------------------SLLAIKVKRRTLLISSKF- 207
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 442631927 355 sLRISVVIIIAFLICWTPYYVMMIMFMFLNPDKRLGDDLQDAIFF---FGMSNSLVNPLIY 412
Cdd:cd15119  208 -FWTISAVIVAFFVCWTPYHIFSILELSIHHSSYLHNVLRAGIPLatsLAFINSCLNPILY 267
7tmA_BRS-3 cd15123
bombesin receptor subtype 3, member of the class A family of seven-transmembrane G ...
126-410 6.67e-08

bombesin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; BRS-3 is classified as an orphan receptor and belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and gastrin-releasing peptide receptor (GRPR). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple primarily to the G proteins of G(q/11) family. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. BRS-3 is suggested to play a role in sperm cell division and maturation.


Pssm-ID: 320251 [Multi-domain]  Cd Length: 294  Bit Score: 54.54  E-value: 6.67e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 126 AVMALFSLLGNLLTIWNIYKTRisrrnSRHTWSAIYslMFHLSIADVLVTWFCIIGEAAWCYTVQWLANELTCKLVKLFQ 205
Cdd:cd15123    8 AVIISVGILGNAILIKVFFKIK-----SMQTVPNIF--ITSLAFGDLLLLLTCVPVDATRYIADTWLFGRIGCKLLSFIQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 206 MFSLYLSTYVLVLIGVDRWIAVKYPMK---SLNMAKRCHRlLGGTYILSLVLSLPQ--FFIFHVARGPFVE-EFYQCVTH 279
Cdd:cd15123   81 LTSVGVSVFTLTVLSADRYRAIVKPLElqtSDAVLKTCCK-AGCVWIVSMLFAIPEavFSDLYSFRDPEKNtTFEACAPY 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 280 GFYTADWQEQMYATFTLVFtFLLPLCILFGTYMSTFRTISSsekmfqgsklanySTAKLPTQTNRQRLIHKAKMKSLRIS 359
Cdd:cd15123  160 PVSEKILQEIHSLLCFLVF-YIIPLSIISVYYFLIARTLYK-------------STFNMPAEEHSHARKQIESRKRVAKT 225
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 442631927 360 VVIIIA-FLICWTPYYVMMIM--FMFLNPDKRLGDDLQDAIF--FFGMSNSLVNPL 410
Cdd:cd15123  226 VLVLVAlFAFCWLPNHILYLYrsFTYHTSVDSSAFHLIATIFsrVLAFSNSCVNPF 281
7tmA_SWS1_opsin cd15076
short wave-sensitive 1 opsins, member of the class A family of seven-transmembrane G ...
216-412 7.83e-08

short wave-sensitive 1 opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Short Wave-Sensitive opsin 1 (SWS1), which mediates visual transduction in response to light at short wavelengths (ultraviolet to blue). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320204 [Multi-domain]  Cd Length: 280  Bit Score: 54.05  E-value: 7.83e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 216 LVLIGVDRWIAVKYPMKSLNMAKRcHRLL--GGTYILSLVLSLPQFFifhvARGPFVEEFYQCVTH-GFYT--ADWQEQM 290
Cdd:cd15076   91 LAFLAFERYIVICKPFGNFRFGSK-HALGavVATWIIGIGVSLPPFF----GWSRYIPEGLQCSCGpDWYTvgTKYRSEY 165
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 291 YATFTLVFTFLLPLCILFGTYMSTFRTISSSEKMFQGSKlanystaklPTQtnrqrlihKAKMKSLRISVVIIIAFLICW 370
Cdd:cd15076  166 YTWFLFIFCFIVPLSIIIFSYSQLLGALRAVAAQQQESA---------STQ--------KAEREVSRMVVVMVGSFCLCY 228
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 442631927 371 TPYYVMMiMFMFLNPDKRLGDDLQDAIFFFGMSNSLVNPLIY 412
Cdd:cd15076  229 VPYAALA-MYMVNNRDHGLDLRLVTIPAFFSKSSCVYNPIIY 269
7tmA_CCR3 cd15185
CC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
133-382 8.01e-08

CC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR3 is a highly promiscuous receptor that binds a variety of inflammatory CC-type chemokines, including CCL11 (eotaxin-1), CCL3L1, CCL5 (regulated on activation, normal T cell expressed and secreted; RANTES), CCL7 (monocyte-specific chemokine 3 or MCP-3), CCL8 (MCP-2), CCL11, CCL13 (MCP-4), CCL15, CCL24 (eotaxin-2), CCL26 (eotaxin-3), and CCL28. Among these, the eosinophil chemotactic chemokines (CCL11, CCL24, and CCL26) are the most potent and specific ligands. In addition to eosinophil, CCR3 is expressed on cells involved in allergic responses, such as basophils, Th2 lymphocytes, and mast cells. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341339 [Multi-domain]  Cd Length: 278  Bit Score: 54.06  E-value: 8.01e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 133 LLGNLLTIWNIYKTRISRrnsrhTWSAIYslMFHLSIADVLVTWFCIIgeaaWCYTV---QWLANELTCKLVKLFQMFSL 209
Cdd:cd15185   15 LLGNVVVVVILIKYRRLR-----IMTNIY--LLNLAISDLLFLFTLPF----WIHYVrwnNWVFGHGMCKLLSGFYYLGL 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 210 YLSTYVLVLIGVDRWIAVKYPMKSLNMAKRCHRLLGG--TYILSLVLSLPQfFIFHVARGPFvEEFYQCVTHGFYTADWQ 287
Cdd:cd15185   84 YSEIFFIILLTIDRYLAIVHAVFALRARTVTFGIITSiiTWGLAVLAALPE-FIFYETQELF-EEFLCSPLYPEDTEDSW 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 288 EQMYATFTLVFTFLLPLCILFGTYMSTFRTIsssekmfqgsklanystaklptqtnrQRLIHKAKMKSLRISVVIIIAFL 367
Cdd:cd15185  162 KRFHALRMNIFGLALPLLIMVICYTGIIKTL--------------------------LRCPSKKKYKAIRLIFVIMVVFF 215
                        250
                 ....*....|....*
gi 442631927 368 ICWTPYYVMMIMFMF 382
Cdd:cd15185  216 IFWTPYNLVLLLSAF 230
7tmA_BK-1 cd15380
bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled ...
127-412 8.92e-08

bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320502 [Multi-domain]  Cd Length: 286  Bit Score: 54.03  E-value: 8.92e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 127 VMALFSLLGNL--LTIWNIYKTRIsrrnsrhTWSAIYslMFHLSIAD-VLVTWFCIIGEAAWcYTVQWLANELTCKLVKL 203
Cdd:cd15380    9 AICFFGLLGNLfvLFVFLLPRRRL-------TIAEIY--LANLAASDlVFVLGLPFWAENIR-NQFNWPFGNFLCRVISG 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 204 FQMFSLYLSTYVLVLIGVDRWIAVKYPMKSlnMAKRCHRLLGGT----YILSLVLSLPQFFIFHVARGPFVEeFYQCVTH 279
Cdd:cd15380   79 VIKANLFISIFLVVAISQDRYRTLVHTMTS--RRQRSRRQAQVIclliWVFGGLLSIPTFLFRSVKHVPDLN-ISACILL 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 280 gFYTADWQEQMYATFTLVfTFLLPL-CILFGTYMSTfrtISSSEKmfqgsklanystaklpTQTNRQRLIHKAKMKSLRI 358
Cdd:cd15380  156 -FPHEAWHFARRVELNIV-GFLLPLaAIVFFNFHII---ASLRER----------------TEESRKRCGGLKDTKATRL 214
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 442631927 359 SVVIIIAFLICWTPYYvmmiMFMFLNPDKRLgDDLQDAIF------------FFGMSNSLVNPLIY 412
Cdd:cd15380  215 ILTLVLMFLVCWTPYH----FFAFLDFLFQV-EVIQGCFWeefidlglqlanFFAFANSCLNPVIY 275
7tmA_AT1R cd15192
type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
190-415 1.00e-07

type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 320320 [Multi-domain]  Cd Length: 285  Bit Score: 53.97  E-value: 1.00e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 190 QWLANELTCKLVKLFQMFSLYLSTYVLVLIGVDRWIAVKYPMKSlnmakRCHRLL-------GGTYILSLVLSLPQFFIF 262
Cdd:cd15192   65 HWPFGNFLCKIASALVSFNLYASVFLLTCLSIDRYLAIVHPMKS-----RLRRTLvvarvtcIVIWLLAGVASLPAIIHR 139
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 263 HVArgpFVEEFYQCVThGFYTADWQEQMYATFTLV---FTFLLPLCILFGTYMSTFRTISSSEKMfqgsklanystaklp 339
Cdd:cd15192  140 DVF---FIENTNITVC-AFHYPSQNSTLLVGLGLMknlLGFLIPFLIILTCYTLIGKALKKAYEI--------------- 200
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 340 tQTNRQRlihkaKMKSLRISVVIIIAFLICWTPYYVMMIMFMFLN----PDKRLGDDLQDAIFF---FGMSNSLVNPLIY 412
Cdd:cd15192  201 -QRNKPR-----NDEIFKMIMAVVLFFFFCWIPHQIFTFLDVLIQlkviQDCHIADIVDTAMPFticIAYFNSCLNPILY 274

                 ...
gi 442631927 413 GAF 415
Cdd:cd15192  275 GFV 277
7tmA_GPR182 cd14988
G protein-coupled receptor 182, member of the class A family of seven-transmembrane G ...
127-412 1.02e-07

G protein-coupled receptor 182, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR182 is an orphan G-protein coupled receptor that belongs to the class A of seven-transmembrane GPCR superfamily. When GPR182 gene was first cloned, it was proposed to encode an adrenomedullin receptor. However when the corresponding protein was expressed, it was found not to respond to adrenomedullin (ADM). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320119 [Multi-domain]  Cd Length: 278  Bit Score: 53.62  E-value: 1.02e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 127 VMALFSLLGNLLTIWNIYKtrisrrnSRHTWSAIYSLMFHLSIAD--VLVTWFCIIGEAAWCYTvqWLANELTCKLVKLF 204
Cdd:cd14988    9 VIFVVGLVENVLVIWVNWH-------RWGSKNLVNLYILNMAIADlgVVLTLPVWMLEVMLDYT--WLWGSFLCKFTHYF 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 205 QMFSLYLSTYVLVLIGVDRWIAVKYPMKSLNMAK-RCHRLL-GGTYILSLVLSLPQffIFHVARGPFVEEFyqCVTHG-F 281
Cdd:cd14988   80 YFANMYSSIFFLTCLSVDRYLTLTSSSPFWQQHQhRIRRALcAGIWVLSAIIPLPE--VVHMQLLDGVEPM--CLFLApF 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 282 YTADWQEQMYATFTLVFTFLLPLCILFGTYMSTFRTISSSEKmfqgsklanystaklPTQTNRQRLIHkakmkslrisvV 361
Cdd:cd14988  156 ETYDEWALAVSLLTLIIGFLIPFSIIAVFNVLTARYIRTAGR---------------PESRRHCLLIY-----------A 209
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 442631927 362 IIIAFLICWTPYYVMMIMFMFLNPDKRLGDDLQDAIFFF-------GMSNSLVNPLIY 412
Cdd:cd14988  210 YILVFVVCWLPYHVTLLLLTLHGSHISLHCNLVHFLYFFydvidcfSLLHCVANPILY 267
7tmA_5-HT4 cd15056
serotonin receptor subtype 4, member of the class A family of seven-transmembrane G ...
124-415 1.13e-07

serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT4 subtype is a member of the serotonin receptor family that belongs to the class A G protein-coupled receptors, and binds the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT4 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. 5-HT4 receptor-specific agonists have been shown to enhance learning and memory in animal studies. Moreover, hippocampal 5-HT4 receptor expression has been reported to be inversely correlated with memory performance in humans. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320184 [Multi-domain]  Cd Length: 294  Bit Score: 53.65  E-value: 1.13e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 124 VLAVMALFSLLGNLLTIWNIYKTRISRRNSRHtwsaiysLMFHLSIADVLVTWFCIIGEAAWCYTVQWLANELTCKLVKL 203
Cdd:cd15056    6 FLSLVILLTILGNLLVIVAVCTDRQLRKKTNY-------FVVSLAVADLLVAVLVMPFGAIELVNNRWIYGETFCLVRTS 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 204 FQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLNMA-KRCHRLLGGTYILSLVLS-LPqffifhVARGPFVEEFYQCVTHGF 281
Cdd:cd15056   79 LDVLLTTASIMHLCCIALDRYYAICCQPLVYKMTpLRVAVMLGGCWVIPTFISfLP------IMQGWNHIGIEDLIAFNC 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 282 -----YTADWQEQMYATFTLVFTFLLPLCILFGTYMSTFRTisSSEKMFQGSKL-ANYSTAKLPTQTNRQRLIHKAKM-K 354
Cdd:cd15056  153 asgstSCVFMVNKPFAIICSTVAFYIPALLMVLAYYRIYVA--AREQAHQIRSLqRAGSSNHEADQHRNSRMRTETKAaK 230
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 442631927 355 SLRIsvvIIIAFLICWTPYYVMMIMFMFLNpdKRLGDDLQDAIFFFGMSNSLVNPLIYGAF 415
Cdd:cd15056  231 TLGI---IMGCFCVCWAPFFVTNIVDPFIG--YRVPYLLWTAFLWLGYINSGLNPFLYAFF 286
7tmA_SWS2_opsin cd15077
short wave-sensitive 2 opsins, member of the class A family of seven-transmembrane G ...
126-412 1.14e-07

short wave-sensitive 2 opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Short Wave-Sensitive opsin 2 (SWS2), which mediates visual transduction in response to light at short wavelengths (violet to blue). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320205 [Multi-domain]  Cd Length: 280  Bit Score: 53.68  E-value: 1.14e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 126 AVMALFSLLG---NLLTIWNIYKTRISRrnsrhtwSAIYSLMFHLSIADVLVTWFciiGEAAWCYTVQ---WLANELTCK 199
Cdd:cd15077    5 AFMLFLVIAGfpiNVLTIICTIKYKKLR-------SHLNYILVNLAVANLIVVCF---GSTTAFYSFSqmyFVLGPLACK 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 200 LVKLFQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLNMaKRCHRLLG--GTYILSLVLSLPQFFifhvARGPFVEEFYQCV 277
Cdd:cd15077   75 IEGFTATLGGMVSLWSLAVVAFERFLVICKPLGNFTF-RGTHAIIGciATWVFGLAASLPPLF----GWSRYIPEGLQCS 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 278 TH-GFYTAD--WQEQMYATFTLVFTFLLPLCILFGTYMSTFRTISSSEKMFQGSKlanystaklPTQtnrqrlihKAKMK 354
Cdd:cd15077  150 CGpDWYTTNnkWNNESYVMFLFCFCFGVPLSIIVFSYGRLLLTLRAVAKQQEQSA---------STQ--------KAERE 212
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 442631927 355 SLRISVVIIIAFLICWTPYYVMMIMFMFlNPDKRLGDDLQDAIFFFGMSNSLVNPLIY 412
Cdd:cd15077  213 VTKMVVVMVLGFLVCWLPYASFALWVVT-NRGEPFDLRLASIPSVFSKASTVYNPVIY 269
7tmA_SSTR2 cd15971
somatostatin receptor type 2, member of the class A family of seven-transmembrane G ...
127-412 1.26e-07

somatostatin receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin, a polypeptide hormone that regulates a wide variety of physiological such as neurotransmission, endocrine secretion, cell proliferation, and smooth muscle contractility. SSTRs are composed of five distinct subtypes (SSTR1-5) which are encoded by separate genes on different chromosomes. SSTR2 plays critical roles in growth hormone secretion, glucagon secretion, and immune responses. SSTR2 is expressed in the normal human pituitary and in nearly all pituitary growth hormone adenomas.


Pssm-ID: 320637 [Multi-domain]  Cd Length: 279  Bit Score: 53.69  E-value: 1.26e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 127 VMALFSLLGNLLTIWNIYktrisRRNSRHTWSAIYSLmfHLSIADVLVTW---FCIIGEAawcyTVQWLANELTCKLVKL 203
Cdd:cd15971    9 VVCIIGLCGNTLVIYVIL-----RYAKMKTVTNIYIL--NLAIADELFMLglpFLAIQVA----LVHWPFGKAICRVVMT 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 204 FQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLNMAK-RCHRLL-GGTYILSLVLSLPQFFIFHVAR---GPFVEEFYQCVT 278
Cdd:cd15971   78 VDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRKpRTAKMInMAVWGVSLLVILPIMIYAGVQTkhgRSSCTIIWPGES 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 279 HGFYTAdwqeqmYATFTLVFTFLLPLCILFGTYMSTFRTISSSEKMFQGSKLanystaklptqtnrqrliHKAKMKSLRI 358
Cdd:cd15971  158 SAWYTG------FIIYTFILGFFVPLTIICLCYLFIIIKVKSSGIRVGSSKR------------------KKSEKKVTRM 213
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 442631927 359 SVVIIIAFLICWTPYYVMMI--MFMFLNPDKRLgDDLQDAIFFFGMSNSLVNPLIY 412
Cdd:cd15971  214 VSIVVAVFVFCWLPFYIFNVssVSVSISPTPGL-KGMFDFVVVLSYANSCANPILY 268
7tmA_P2Y2 cd15373
P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled ...
156-380 1.28e-07

P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y2 belongs to the P2Y receptor family of purinergic G-protein coupled receptors and is implicated to play a role in the control of the cell cycle of endometrial carcinoma cells. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320495 [Multi-domain]  Cd Length: 283  Bit Score: 53.60  E-value: 1.28e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 156 TWSAIYSLMFHLSIADVLVTWFCIIGEAAWCYTVQWLANELTCKLVKLFQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLN 235
Cdd:cd15373   31 PWNASTTYMFNLAISDTLYVLSLPLLVYYYADENDWPFSEALCKIVRFLFYTNLYCSILFLLCISVHRFLGVCYPVRSLR 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 236 MAK-RCHRLL-GGTYILSLVLSLP-QFFIFHVARGPFVeefyqcVTHGFYTADWQEQ--MYATFTLVFTFLLPLCILFGT 310
Cdd:cd15373  111 WLKvRYARIVsVVVWVIVLACQSPvLYFVTTSDKGGNI------TCHDTSSPELFDQfvVYSSVMLVLLFCVPFVVILVC 184
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 311 YMSTFRtisssekmfqgsKLANYSTAKLPTQtnrqrlihKAKMKSLRISVVIIIAFLICWTPYYVMMIMF 380
Cdd:cd15373  185 YALMVR------------KLLKPSAGTSTNS--------RSKKKSVKMIIIVLAVFILCFLPFHVTRTLY 234
7tmA_5-HT1F cd15334
serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G ...
125-416 1.43e-07

serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320456 [Multi-domain]  Cd Length: 259  Bit Score: 53.03  E-value: 1.43e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 125 LAVMALFSLLGNLLTIWNIYKTRISRRNSRHtwsaiysLMFHLSIADVLVTWFCIIGEAAWCYTVQWLANELTCKLVKLF 204
Cdd:cd15334    7 LSILALMTTAINSLVITAIIVTRKLHHPANY-------LICSLAVTDFLVAVLVMPFSIMYIVKETWIMGQVVCDIWLSV 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 205 QMFSLYLSTYVLVLIGVDRWIA----VKYPMKslNMAKRCHRLLGGTYILSLVLSLPQFFIFHVArgpfVEEFYQCVT-- 278
Cdd:cd15334   80 DITCCTCSILHLSAIALDRYRAitdaVEYARK--RTPKHAGIMIAVVWIISIFISMPPLFWRHQT----TSREDECIIkh 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 279 -HGFYTadwqeqMYATFTlvfTFLLPLCILFGTYMSTFRTISSSEKmfqgsklANYSTAklptqtnrqrlihkakmkslr 357
Cdd:cd15334  154 dHIVFT------IYSTFG---AFYIPLALILILYYKIYRAATRERK-------AATTLG--------------------- 196
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 442631927 358 isvVIIIAFLICWTPYYVMMIMFMFLNPDKrLGDDLQDAIFFFGMSNSLVNPLIYGAFH 416
Cdd:cd15334  197 ---LILGAFVICWLPFFVKEVIVNTCDSCY-ISEEMSNFLTWLGYINSLINPLIYTIFN 251
7tmA_Glyco_hormone_R cd15136
glycoprotein hormone receptors, member of the class A family of seven-transmembrane G ...
127-411 1.51e-07

glycoprotein hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors (GPHRs) are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG) and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. GPHRs couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein.


Pssm-ID: 320264 [Multi-domain]  Cd Length: 275  Bit Score: 53.37  E-value: 1.51e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 127 VMALFSLLGNLLTIWNIYktrISRRNSRHTwsaiYSLMFHLSIADvlvtwFCI--------------IGEAAwCYTVQWl 192
Cdd:cd15136    9 FVFLLALVGNIIVLLVLL---TSRTKLTVP----RFLMCNLAFAD-----FCMgiylgllaivdaktLGEYY-NYAIDW- 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 193 ANELTCKLVKLFQMFSLYLSTYVLVLIGVDRWIAVKYPM---KSLNMAKRCHRLLGGtYILSLVL-SLPqffIFHVARgp 268
Cdd:cd15136   75 QTGAGCKTAGFLAVFSSELSVFTLTVITLERWYAITHAMhlnKRLSLRQAAIIMLGG-WIFALIMaLLP---LVGVSS-- 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 269 fveefYQ--CVTHGFYTADWQEQMYATFTLVFTFlLPLCILFGTYMSTFRTISSSEkmfqgsklanystakLPTQTNRQR 346
Cdd:cd15136  149 -----YSktSICLPFETETPVSKAYVIFLLLFNG-LAFLIICGCYIKIYLSVRGSG---------------RAANSNDTR 207
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 442631927 347 LIhkakmksLRISVVIIIAFLiCWTPyyvmmimfmflnpdkrlgddlqdaIFFFGMSNSLVNPLI 411
Cdd:cd15136  208 IA-------KRMALLVFTDFL-CWAP------------------------IAFFGLTAAFGLPLI 240
7tmA_alpha2C_AR cd15323
alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G ...
124-416 1.92e-07

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320446 [Multi-domain]  Cd Length: 261  Bit Score: 52.63  E-value: 1.92e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 124 VLAVMALFSLLGNLLTIwniyktrISRRNSRHTWSAIYSLMFHLSIADVLVTWFCIIGEAAWCYTVQWLANELTCKLVKL 203
Cdd:cd15323    6 VVGFLIVFTIVGNVLVV-------IAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMGYWYFGQVWCNIYLA 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 204 FQMFSLYLSTYVLVLIGVDRWI----AVKYPMKslNMAKRCHRLLGGTYILSLVLSLPQFFIFHvaRGPFVEEFYQCVTH 279
Cdd:cd15323   79 LDVLFCTSSIVHLCAISLDRYWsvtqAVEYNLK--RTPRRVKAIIVTVWLISAVISFPPLISMY--RDPEGDVYPQCKLN 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 280 gfytadwQEQMYATFTLVFTFLLPLCILFGTYMSTFRTISSSEKMFQgsklanystaklptqtnrqrlihkakmkslRIS 359
Cdd:cd15323  155 -------DETWYILSSCIGSFFAPCLIMILVYIRIYRVAKAREKRFT------------------------------FVL 197
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 442631927 360 VVIIIAFLICWTPYYVMMIMFMFLNPDKRLGDDLQDAIFFFGMSNSLVNPLIYGAFH 416
Cdd:cd15323  198 AVVMGVFVVCWFPFFFSYSLYGICREACEVPEPLFKFFFWIGYCNSSLNPVIYTIFN 254
7tmA_GPR161 cd15214
orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G ...
127-413 2.01e-07

orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR161, an orphan GPCR, is a negative regulator of Sonic hedgehog (Shh) signaling, which promotes the processing of zinc finger protein GLI3 into its transcriptional repressor form (GLI3R) during neural tube development. In the absence of Shh, this proteolytic processing is normally mediated by cAMP-dependent protein kinase A (PKA). GPR161 is recruited to primary cilia by a mechanism depends on TULP3 (tubby-related protein 3) and the intraflagellar complex A (IFT-A). Moreover, Gpr161 knockout mice show phenotypes observed in Tulp3/IFT-A mutants, and cause increased Shh signaling in the neural tube. Taken together, GPR161 negatively regulates the PKA-dependent GLI3 processing in the absence of Shh signal by coupling to G(s) protein, which causes activation of adenylate cyclase, elevated cAMP levels, and activation of PKA. Conversely, in the presence of Shh, GPR161 is removed from the cilia by internalization into the endosomal recycling compartment, leading to downregulation of its activity and thereby allowing Shh signaling to proceed. In addition, GPR161 is over-expressed in triple-negative breast cancer (lacking estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (HER2) expression) and correlates with poor prognosis. Mutations of GPR161 have also been implicated as a novel cause for pituitary stalk interruption syndrome (PSIS), a rare congenital disease of the pituitary gland. GPR161 is a member of the class A family of GPCRs, which contains receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320342 [Multi-domain]  Cd Length: 261  Bit Score: 52.63  E-value: 2.01e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 127 VMALFSLLGNLLTIWNIYKTRISRRNSRhtwSAIYSLMFHLSIADVLVTWFCIIGEA--AWCYTVQWlaneltCKLVKLF 204
Cdd:cd15214    8 IIAILICLGNLVIVVTLYKKSYLLTLSN---KFVFSLTLSNLLLSVLVLPFVVTSSIrrEWIFGVVW------CNFSALL 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 205 QMFSLYLSTYVLVLIGVDRWIAVKYPMKSLNMAKRCHRLLGGTYIL--SLVLSLPQFFIFHVARgpFVEEFYQCVthgfy 282
Cdd:cd15214   79 YLLISSASMLTLGAIAIDRYYAVLYPMVYPMKITGNRAVLALVYIWlhSLIGCLPPLFGWSSLE--FDRFKWMCV----- 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 283 tADW-QEQMYATFTLVFTFLLPLCILFGTYMSTFRTISSSEkmfqgsklanystaklptqtnrqrlihkakMKSLRISVV 361
Cdd:cd15214  152 -AAWhKEAGYTAFWQVWCALLPFVVMLVCYGFIFRVARANQ------------------------------CKAFITILV 200
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 442631927 362 IIIAFLICWTPyYVMMIMFMFLNPDKRLGDDLQDAIFFFGMSNSLVNPLIYG 413
Cdd:cd15214  201 VLGAFVTTWGP-YMVVISTEALWGKNSVSPQLETLATWLSFTSAVCHPLIYG 251
7tmA_mAChR cd15049
muscarinic acetylcholine receptor subfamily, member of the class A family of ...
124-412 2.12e-07

muscarinic acetylcholine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341322 [Multi-domain]  Cd Length: 262  Bit Score: 52.71  E-value: 2.12e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 124 VLAVMALFSLLGNLLTIWNIYKTRISRRNSRHtwsaiysLMFHLSIADVLV--------TWFCIIGE----AAWCYTvqW 191
Cdd:cd15049    6 ATGSLSLVTVGGNILVILSFRVNRQLRTVNNY-------FLLSLACADLIIglvsmnlyTVYLVMGYwplgPLLCDL--W 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 192 LANELTCKLVklfqmfslylSTYVLVLIGVDRWIAVKYPMKSLN--MAKRCHRLLGGTYILSLVLSLPQFFIFHVARGPF 269
Cdd:cd15049   77 LALDYVASNA----------SVMNLLLISFDRYFSVTRPLTYRAkrTPKRAILMIALAWVISFVLWAPAILGWQYFVGER 146
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 270 VEEFYQCvthgfYTADWQEQMYATFTLVFTFLLPLCILFGTYMSTFRTisssekmfqgsklanystaklptqTNRQRlih 349
Cdd:cd15049  147 TVPDGQC-----YIQFLDDPAITFGTAIAAFYLPVLVMTILYWRIYRE------------------------TARER--- 194
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 442631927 350 kakmKSLRISVVIIIAFLICWTPYYVMMIMFMFLnpDKRLGDDLQDAIFFFGMSNSLVNPLIY 412
Cdd:cd15049  195 ----KAARTLSAILLAFIITWTPYNILVLVSTFC--AKCIPDTLWSFGYWLCYINSTINPFCY 251
7tmA_GPR34-like cd15920
P2Y-like receptor and similar proteins, member of the class A family of seven-transmembrane G ...
132-412 2.47e-07

P2Y-like receptor and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR34 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. GPR34 is shown to couple to G(i/o) protein and is highly expressed in microglia. Recently, lysophosphatidylserine has been identified as a ligand for GPR34. This group belongs to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320586 [Multi-domain]  Cd Length: 278  Bit Score: 52.49  E-value: 2.47e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 132 SLLGNLLTIWNIYktrisRRNSRHTWSAIYslMFHLSIADVLVTwFCIIGEAAWcytVQWLANELTCKLVKLFQMFSLYL 211
Cdd:cd15920   14 GLLSNTLALWVFF-----LRQQRETSISVY--MRNLALADLLLV-LCLPFRVAY---QNTAGPLSFCKIVGAFFYLNMYA 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 212 STYVLVLIGVDRWIAVKYPMKSLNMAKR--CHRLLGGTYILSLVLSLPqFFIFHVARGPFVEEFYQCVTHGFYTAdwqeq 289
Cdd:cd15920   83 SILFLSLISLDRYLKIIKPLQQFKIHTVpwSSAASGGVWLLLLACMIP-FLFESRNEGPCDNKCFHFRSKGLTAG----- 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 290 mYATFTLVFTFLLpLCILFgtymstfrtISSSEKMFqgSKLANYStaklptQTNRQRLIHKAKMKSLRISVVIIIAFLIC 369
Cdd:cd15920  157 -GINLTAVVIFYI-LSLLF---------LYFYAKIS--HKLYKVS------LGNAQQQIKKASKRAIIKTFIVLAIFIVC 217
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 442631927 370 WTPYYVMMIMFMFLN-------PDKRLGDDLQDAIFFFGMSNSLVNPLIY 412
Cdd:cd15920  218 FVPYHIVRVPYVLAQidvisslPWKQTLHIANELVLCLSALNSCLDPIIY 267
7tmA_5-HT1B_1D cd15333
serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G ...
124-415 2.52e-07

serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320455 [Multi-domain]  Cd Length: 265  Bit Score: 52.49  E-value: 2.52e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 124 VLAVMALFSLLGNLLTIWNIYKTRisrrnSRHTwSAIYsLMFHLSIADVLVTWFCIIGEAAWCYTVQWLANELTCKLVKL 203
Cdd:cd15333   10 LLALITLATTLSNAFVIATIYLTR-----KLHT-PANY-LIASLAVTDLLVSILVMPISIVYTVTGTWTLGQVVCDIWLS 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 204 FQMFSLYLSTYVLVLIGVDRWI----AVKYPMKslNMAKRCHRLLGGTYILSLVLSLPQFFIFHVARGpfvEEFYQCVT- 278
Cdd:cd15333   83 SDITCCTASILHLCVIALDRYWaitdAVEYSKK--RTPKRAAVMIALVWVISISISLPPFFWRQAKAE---EEVSECVVn 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 279 --HGFYTadwqeqMYATFTlvfTFLLPLCILFGTYMSTFRTISSSEKmfqgsklanystaklptqtnrqrlihkakmKSL 356
Cdd:cd15333  158 tdHILYT------VYSTVG---AFYIPTLLLIALYGRIYVEARARER------------------------------KAT 198
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 442631927 357 RISVVIIIAFLICWTPYYVMMIMFMFLNPDKRLGDDLQDAIFFFGMSNSLVNPLIYGAF 415
Cdd:cd15333  199 KTLGIILGAFIVCWLPFFIISLVLPICKDACWFHLAIFDFFTWLGYLNSLINPIIYTMS 257
7tmA_GPR55-like cd15165
G protein-coupled receptor 55 and similar proteins, member of the class A family of ...
131-400 2.54e-07

G protein-coupled receptor 55 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR55 shares closest homology with GPR35, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Lysophosphatidylinositol (LPI) is currently considered as the endogenous ligand for GPR55, although the receptor was initially de-orphanized as a cannabinoid receptor and binds many cannabinoid ligands.


Pssm-ID: 320293 [Multi-domain]  Cd Length: 277  Bit Score: 52.72  E-value: 2.54e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 131 FSLLGNLLTIWnIYKTRISRRnsrhTWSAIYslMFHLSIADVLVTW---FCIIGeaawcYTVQWLANELTCKLVKLFQMF 207
Cdd:cd15165   13 LGLLLNLMALW-VFLFKIKKW----TESTIY--MINLALNDLLLLLslpFKMHS-----SKKQWPLGRTLCSFLESLYFV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 208 SLYLSTYVLVLIGVDRWIAVKYPM--KSLNMAKRCHRLLGGTYILSLVLSLPqFFIFHVARGPFVEEFyqcvtHGFYTAD 285
Cdd:cd15165   81 NMYGSILIIVCISVDRYIAIRHPFlaKRLRSPRKAAIVCLTIWVFVWAGSIP-IYSFHDKPTNNTRCF-----HGFSNKT 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 286 WQEQMYATfTLVFTFLLPLCILFGTYMSTFRTISSSekmfqgsklanystaKLPTQTNRQrlihkaKMKSLRISVVIIIA 365
Cdd:cd15165  155 WSKKVIVV-VEEFGFLIPMAVMVFCSVQIIRTLLDM---------------RRPEQPKVK------QNKSVKIVLSNLVV 212
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 442631927 366 FLICWTPYYVMMIMFMFLNPDKRLGDDLQDAIFFF 400
Cdd:cd15165  213 FLVCFTPYHLGIFLQFLVKNDIINDCSTKQSIRLF 247
7tmA_Histamine_H4R cd15295
histamine receptor subtype H4R, member of the class A family of seven-transmembrane G ...
122-416 2.87e-07

histamine receptor subtype H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtype H4R, a member of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320422 [Multi-domain]  Cd Length: 267  Bit Score: 52.52  E-value: 2.87e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 122 VYVLAVMALFSL---LGNLLTIWNIyktrISRRNSRHTWSaiySLMFHLSIADVLVTWFCIIGEAAWCYTVQWLANELTC 198
Cdd:cd15295    1 VVLLFLMSLLALvivLGNALVIIAF----VVDKNLRHRSN---YFFLNLAISDFFVGAISIPLYIPYTLTNRWDFGRGLC 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 199 KLVKLFQMFSLYLSTYVLVLIGVDRWI----AVKYPMKSLNMAkRCHRLLGGTYILSLVLSLPQFFIFHVARgpfvEEFY 274
Cdd:cd15295   74 VFWLVIDYLLCTASVYNIVLISYDRYQsvsnAVSYRNQQTATL-RIVTQMVAVWVLAFLVHGPAILVSDSWK----TEDG 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 275 QCVThGFYTadwqEQMYATFTLVFTFLLPLCILFGTYMSTFRTIsssekmfqgsklanystaklptqtnRQRLIHKAKMK 354
Cdd:cd15295  149 ECEP-EFFS----NWYILAITSVLEFLVPVILVAYFNTQIYWSL-------------------------WKRLRDRKLAK 198
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 442631927 355 SLRIsvvIIIAFLICWTPYYVMMIMFMFLNpdKRLGDDLQDAIFFFGMSNSLVNPLIYGAFH 416
Cdd:cd15295  199 SLAI---ILGTFAICWAPYSLFTIIRAACE--KHRGSPWYNFAFWLQWFNSFINPFLYPLCH 255
7tmA_BK-2 cd15381
bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled ...
190-412 3.05e-07

bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320503 [Multi-domain]  Cd Length: 284  Bit Score: 52.46  E-value: 3.05e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 190 QWLANELTCKLVKLFQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLNMAK-RCHRLLG-GTYILSLVLSLPQfFIFHVARG 267
Cdd:cd15381   65 NWPFGEFLCKSVNAVIYMNLYSSIYFLMMVSIDRYLALVKTMSSGRMRRpACAKLNClIIWMFGLLMSTPM-IVFRTVMY 143
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 268 PFVEEFYQCVTHgfYTADWQEQMYATFTLVFTFLLPLCILfgTYMSTFRTISssekmfqgskLANYSTAKLptqtnrqRL 347
Cdd:cd15381  144 FPEYNITACVLD--YPSEGWHVALNILLNVVGFLIPLSII--TFCSTQIIQV----------LRNNKMQKF-------KE 202
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 442631927 348 IHKAKMKSLRISVVIIIaFLICWTPYYVMMIM----FMFLNPDKRLGDDLQDA---IFFFGMSNSLVNPLIY 412
Cdd:cd15381  203 IQTERKATVLVLAVLLM-FFICWLPFHIFTFLdtlhKLGLISGCRWEDILDIGtqiATFLAYSNSCLNPLLY 273
7tmA_CX3CR1 cd15186
CX3C chemokine receptor 1, member of the class A family of seven-transmembrane G ...
119-412 3.50e-07

CX3C chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; CX3CR1 is an inflammatory receptor specific for CX3CL1 (also known as fractalkine in human), which is involved in the adhesion and migration of leukocytes. The CX3C chemokine subfamily is only represented by CX3CL1, which exists in both soluble and membrane-anchored forms. Membrane-anchored form promotes strong adhesion of receptor-bearing leukocytes to CX3CL1-expressing endothelial cells. On the other hand, soluble CX3CL1, which is released by the proteolytic cleavage of membrane-anchored CX3CL1, is a potent chemoattractant for CX3CR1-expressing T cells and monocytes. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 320314 [Multi-domain]  Cd Length: 273  Bit Score: 52.14  E-value: 3.50e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 119 LLKVYVLAVMAlFSLLGNLLTIWNIYKTRISRrnsrhTWSAIYslMFHLSIADVLVtwfcIIGEAAWCYTV--QWLANEL 196
Cdd:cd15186    2 FLSIFYSLVFA-FGLVGNLLVVLALTNSGKSK-----SITDIY--LLNLALSDLLF----VATLPFWTHYLinEWGLHNA 69
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 197 TCKLVKLFQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLNMAKRCHRLLG--GTYILSLVLSLPQFFifhvargpFVEEF- 273
Cdd:cd15186   70 MCKLTTAFFFIGFFGGIFFITVISIDRYLAIVLAANSMNNRTVQHGVTIslGVWAAAILVAVPQFM--------FTKMKe 141
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 274 YQCVthGFYTADWQE---QMYATFTLVFTFLLPLCILFGTYMSTFRTISSSEKmfqgsklanystaklptqtnrqrliHK 350
Cdd:cd15186  142 NECL--GDYPEVLQEiwpVLRNVELNFLGFLLPLLIMSYCYFRIIQTLFSCKN-------------------------HK 194
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 442631927 351 aKMKSLRISVVIIIAFLICWTPYYVMMIM----FMFLNPDKRLGDDLQDAIFF---FGMSNSLVNPLIY 412
Cdd:cd15186  195 -KARAIKLILLVVIVFFLFWTPYNVMIFLetlkLYDFFPSCDMKKDLRLALSVtetIAFSHCCLNPLIY 262
7tmA_CysLTR2 cd15157
cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G ...
164-412 3.74e-07

cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320285 [Multi-domain]  Cd Length: 278  Bit Score: 52.02  E-value: 3.74e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 164 MFHLSIADVLVTWFCIIGEAAWCYTVQWLANELTCKLVKLFQMFSLYLSTYVLVLIGVDRWIAVKYPMK--SLNMAKRCH 241
Cdd:cd15157   39 MLNLAVSDLMFVSTLPFRADYYLMGSHWVFGDIACRIMSYSLYVNMYCSIYFLTVLSIVRFLAIVHPFKlwKVTSIKYAR 118
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 242 RLLGGTYILSLVLSLPQFFIFHVARGpfveEFYQCVTHGFYTADwQEQMYATFTLVFTFLLPLCILFGTYMSTFRTIsss 321
Cdd:cd15157  119 ILCAVIWIFVMAASSPLLSKGTSKYN----SQTKCLDLHPSKID-KLLILNYIVLVVGFILPFCTLSICYILIIKAL--- 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 322 ekmfqgsklanystAKLPTQTNRQRLIHKakmKSLRISVVIIIAFLICWTPYYVMMIMFMFLNPDKRLGDDLQDAI---F 398
Cdd:cd15157  191 --------------LKPRVPQSKLRVSHK---KALLTIIITLILFLLCFLPYHILRTVHLMQWSEGQCNLRLHKAVvitL 253
                        250
                 ....*....|....
gi 442631927 399 FFGMSNSLVNPLIY 412
Cdd:cd15157  254 CLAAANSCLDPLLY 267
7tmA_GPR135 cd15212
G protein-coupled receptor 135, member of the class A family of seven-transmembrane G ...
121-414 4.82e-07

G protein-coupled receptor 135, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR135, also known as the somatostatin- and angiotensin-like peptide receptor (SALPR), is found in various tissues including eye, brain, cervix, stomach, and testis. Pharmacological studies have shown that relaxin-3 (R3) is a high-affinity endogenous ligand for GPR135. R3 has recently been identified as a new member of the insulin/relaxin family of peptide hormones and is exclusively expressed in the brain neurons. In addition to GPR135, R3 also acts as an agonist for GPR142, a pseudogene in the rat, and can activate LGR7 (leucine repeat-containing G-protein receptor-7), which is the main receptor for relaxin-1 (R1) and relaxin-2 (R2). While R1 and R2 are hormones primarily associated with reproduction and pregnancy, R3 is involved in neuroendocrine and sensory processing. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320340 [Multi-domain]  Cd Length: 285  Bit Score: 51.69  E-value: 4.82e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 121 KVYVLAVMALFSLLGNLLTIWNIYKTRISRrnsrhtwSAIYSLMFHLSIADVLVTWFCIigEAAWCYTVQ---WLANELT 197
Cdd:cd15212    3 QALVLLAIFLLSSLGNCAVIGVIVKHRQLR-------TVTNAFILSLSLSDLLTALLCL--PFAFLTLFSrpgWLFGDRL 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 198 CKLVKLFQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLNMAKRCHRLLGGTYILSLVLSLPQFFIfhvARGPFVEE---FY 274
Cdd:cd15212   74 CLANGFFNACFGIVSTLTMTLISFDRYYAIVRQPQGKIGRRRALQLLAAAWLTALGFSLPWYLL---ASAPEYYEklgFY 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 275 QCVthgfYTADW-QEQMYATFTLVFT---FLLPLCILFGTYMSTFRTISSSEKMFQgsklanystaklPTQTNRQRLIHK 350
Cdd:cd15212  151 HCL----YVLHSgPSRLGAAYSSVLIvlcYLLPFALMCFCHYNICKTVRLSESRVR------------PVTTYAHLLRFY 214
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 442631927 351 AKMKSLRISVVIIIAFLICWTPYYVMMIMF----MFLNPdkrlgdDLQDAIFFFGMSNSLVNPLIYGA 414
Cdd:cd15212  215 SEMRTATTVLIMIVFIICCWGPYCLLGLVAaaggYQFPP------LMDTVAIWMAWANGAINPLIYAI 276
7tmA_Mel1 cd15209
melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
124-413 5.30e-07

melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320337 [Multi-domain]  Cd Length: 279  Bit Score: 51.70  E-value: 5.30e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 124 VLAVMALFSLLGNLLTIWNIYKTRiSRRNSRHTWsaiyslMFHLSIADVLVTWFCIIGEAAWCYTVQWLANELTCKLVKL 203
Cdd:cd15209    6 VLIVTIVVDVLGNLLVILSVLRNK-KLRNAGNIF------VVSLSVADLVVAIYPYPLILHAIFHNGWTLGQLHCQASGF 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 204 FQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLNMAKRCHRL--LGGTYILSLVLSLPQFFIFHVARGPfveEFYQCVTHgf 281
Cdd:cd15209   79 IMGLSVIGSIFNITAIAINRYCYICHSLQYDRLYSLRNTCcyLCLTWLLTVLAVLPNFFIGSLQYDP---RIYSCTFA-- 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 282 YTADWQeqmYATFTLVFTFLLPLCILFGTYMSTFRTISSsekmfqgsklanystAKLPTQTNRQRLIHKAKMKSLRISVV 361
Cdd:cd15209  154 QTVSTV---YTITVVVIHFLLPLLIVSFCYLRIWVLVLQ---------------VRQRVKPDQRPKLKPADVRNFLTMFV 215
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 442631927 362 IIIAFLICWTPYYVMMIMfMFLNPDK---RLGDDLQDAIFFFGMSNSLVNPLIYG 413
Cdd:cd15209  216 VFVLFAVCWAPLNFIGLA-VAINPKEmapKIPEWLFVASYFMAYFNSCLNAIIYG 269
7tmA_GPR35-like cd15164
G protein-coupled receptor 35 and similar proteins, member of the class A family of ...
119-378 6.27e-07

G protein-coupled receptor 35 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR35 shares closest homology with GPR55, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A number of studies have suggested that GPR35 may play important physiological roles in hypertension, atherosclerosis, nociception, asthma, glucose homeostasis and diabetes, and inflammatory bowel disease. GPR35 is thought to be responsible for brachydactyly mental retardation syndrome, which is associated with a deletion comprising chromosome 2q37 in human, and is also implicated as a potential oncogene in stomach cancer. Several endogenous ligands for GPR35 have been identified including kynurenic acid, 2-oleoyl lysophosphatidic acid, and zaprinast. GPR35 couples to G(13) and G(i/o) proteins.


Pssm-ID: 320292 [Multi-domain]  Cd Length: 272  Bit Score: 51.49  E-value: 6.27e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 119 LLKVYVLAVMALFSLLGNLLTIWnIYKTRISRRnsrhTWSAIYslMFHLSIADVLVtwFCIIGEAAWCYTVQWLANELtC 198
Cdd:cd15164    1 LIQLIIYIPILFFGLLFNVLALW-VFCCKMKKW----TETRVY--MINLAVADCCL--LFSLPFVLYFLKHSWPDDEL-C 70
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 199 KLVKLFQMFSLYLSTYVLVLIGVDRWIAVKYPMK--SLNMAKRCHRLLGGTYILSLVlslpqFFIFHVARGPFVEEFyqC 276
Cdd:cd15164   71 LVLQSIYFINRYMSIYIITAIAVDRYIAIKYPLKakSLRSPRKAALTCGLLWVLVII-----SVSLRLAWEEQEENF--C 143
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 277 VTHGfytadwqEQMYATFTLVFT---FLLPLCILfgTYMSTfRTISSSEKmfqgsklanystaKLPTQTNRQRLIHKAkm 353
Cdd:cd15164  144 FGKT-------STRPSKRTLIFSllgFFIPLIIL--SFCSI-QVIRSLKK-------------KKKTNPHEEKLIQKA-- 198
                        250       260
                 ....*....|....*....|....*
gi 442631927 354 ksLRISVVIIIAFLICWTPYYVMMI 378
Cdd:cd15164  199 --IYIVSANLIVFIVCFLPLHIGLL 221
7tmA_5-HT2 cd15052
serotonin receptor subtype 2, member of the class A family of seven-transmembrane G ...
122-415 6.77e-07

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320180 [Multi-domain]  Cd Length: 262  Bit Score: 51.16  E-value: 6.77e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 122 VYVLAVMALFSLLGNLLTIWNIyktRISRRNSRHTwsaIYSLMfHLSIADVLVTW----FCIIGEAawcYTVQWLANELT 197
Cdd:cd15052    4 ALLLLLLVIATIGGNILVCLAI---SLEKRLQNVT---NYFLM-SLAIADLLVGLlvmpLSILTEL---FGGVWPLPLVL 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 198 CKLVKLFQMFSLYLSTYVLVLIGVDRWIAVKYPMK-SLNMAKRCHRL-LGGTYILSLVLSLPqFFIFHVARGPFVEEFYQ 275
Cdd:cd15052   74 CLLWVTLDVLFCTASIMHLCTISLDRYMAIRYPLRtRRNKSRTTVFLkIAIVWLISIGISSP-IPVLGIIDTTNVLNNGT 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 276 CVTHGFYtadwqeqmYATFTLVFTFLLPLCILFGTYMSTFRTIsssekmfqgsklanystaklptqTNRQrlihkakmKS 355
Cdd:cd15052  153 CVLFNPN--------FVIYGSIVAFFIPLLIMVVTYALTIRLL-----------------------SNEQ--------KA 193
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 442631927 356 LRISVVIIIAFLICWTPYYVMMIMFMFL-NPDKRLGDDLQDAIFFFGMSNSLVNPLIYGAF 415
Cdd:cd15052  194 SKVLGIVFAVFVICWCPFFITNILTGLCeECNCRISPWLLSVFVWLGYVSSTINPIIYTIF 254
7tmA_5-HT1E cd15335
serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G ...
119-416 8.00e-07

serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320457 [Multi-domain]  Cd Length: 258  Bit Score: 51.08  E-value: 8.00e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 119 LLKVYVLAVMALFSLLGNLLTIWNIYKTRISRRNSRHtwsaiysLMFHLSIADVLVTWFCIIGEAAWCYTVQWLANELTC 198
Cdd:cd15335    1 MLIVLTLALITILTTVLNSAVIAAICTTKKLHQPANY-------LICSLAVTDFLVAVLVMPLSITYIVMDTWTLGYFIC 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 199 KLVKLFQMFSLYLSTYVLVLIGVDRWIAV----KYPMKslNMAKRCHRLLGGTYILSLVLSLPQFFI--FHVARGPfvee 272
Cdd:cd15335   74 EIWLSVDMTCCTCSILHLCVIALDRYWAItdaiEYARK--RTAKRAGLMILTVWTISIFISIPPLFWrnHHDANIP---- 147
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 273 fYQCVT---HGFYTadwqeqMYATFTlvfTFLLPLCILFGTYMSTFRTISssekmfqgsklanystaklptqtnRQRlih 349
Cdd:cd15335  148 -SQCIIqhdHVIYT------IYSTFG---AFYIPLTLILILYYRIYHAAS------------------------RER--- 190
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 442631927 350 kakmKSLRISVVIIIAFLICWTPYYV--MMIMFMFLNPDKrlgdDLQDAIFFFGMSNSLVNPLIYGAFH 416
Cdd:cd15335  191 ----KAARILGLILGAFILSWLPFFIkeLIVGLSVMTVSP----EVADFLTWLGYVNSLVNPLLYTSFN 251
7tmA_SSTR3 cd15972
somatostatin receptor type 3, member of the class A family of seven-transmembrane G ...
124-413 8.12e-07

somatostatin receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR3 is coupled to inward rectifying potassium channels. SSTR3 plays critical roles in growth hormone secretion, endothelial cell cycle arrest and apoptosis. Furthermore, SSTR3 is expressed in the normal human pituitary and in nearly half of pituitary growth hormone adenomas.


Pssm-ID: 320638 [Multi-domain]  Cd Length: 279  Bit Score: 50.96  E-value: 8.12e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 124 VLAVMALFSLLGNLLTIWNIYktrisRRNSRHTWSAIYSLmfHLSIADVLVTwFCIIGEAAWCYTVQWLANELTCKLVKL 203
Cdd:cd15972    6 VYLVVCVVGLGGNTLVIYVVL-----RYSASESVTNIYIL--NLALADELFM-LGLPFLAAQNALSYWPFGSFMCRLVMT 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 204 FQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLNMAK-RCHRLLGGT-YILSLVLSLPQFFIFHVARGpfveefyqcvtHGF 281
Cdd:cd15972   78 VDAINQFTSIFCLTVMSVDRYLAVVHPIRSSKWRKpPVAKTVNATvWALSFLVVLPVVIFSGVPGG-----------MGT 146
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 282 YTADWQE--QMYATFTLVFT----FLLPLCILFGTYMSTFRTISSSEKMFQgsklanystaklPTQTNRQRlihkAKMKS 355
Cdd:cd15972  147 CHIAWPEpaQVWRAGFIIYTatlgFFCPLLVICLCYLLIVVKVRSSGRRVR------------ATSTKRRG----SERKV 210
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 442631927 356 LRISVVIIIAFLICWTPYYVMMIMFMFLNPDKRlgDDLQDAIFF---FGMSNSLVNPLIYG 413
Cdd:cd15972  211 TRMVVIVVAAFVLCWLPFYALNIVNLVCPLPEE--PSLFGLYFFvvvLSYANSCANPIIYG 269
7tmA_mAChR_GAR-2-like cd15302
muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of ...
124-412 9.66e-07

muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320429 [Multi-domain]  Cd Length: 266  Bit Score: 50.90  E-value: 9.66e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 124 VLAVMALFSLLGNLLTIWNIYKTRISRRNSRHtwsaiysLMFHLSIADVLvtwfciIG-EAAWCYTV------QWLANEL 196
Cdd:cd15302    6 ITAILSIITVIGNILVLLSFYVDRNIRQPSNY-------FIASLAVSDLL------IGlESMPFYTVyvlngdYWPLGWV 72
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 197 TCKLVkLFQMFSLYL-STYVLVLIGVDRWIAVKYPMKSLN--MAKRCHRLLGGTYILSLVLslpqFFIFHVARGPFVEEF 273
Cdd:cd15302   73 LCDLW-LSVDYTVCLvSIYTVLLITIDRYCSVKIPAKYRNwrTPRKVLLIIAITWIIPALL----FFISIFGWQYFTGQG 147
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 274 YQCVTHGFYTADWQEQMYATFTLVFTFLLPLCILFGTYMSTFRTisssekmfqgsklanystaklptqTNRQRlihkakm 353
Cdd:cd15302  148 RSLPEGECYVQFMTDPYFNMGMYIGYYWTTLIVMLILYAGIYRA------------------------ANRAR------- 196
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 442631927 354 KSLRISVVIIIAFLICWTPYYVMMIMFMFLNPDKRLGDDLQDAIFFFGMSNSLVNPLIY 412
Cdd:cd15302  197 KALRTITFILGAFVICWTPYHILATIYGFCEAPPCVNETLYTISYYLCYMNSPINPFCY 255
7tmA_PAR3 cd15371
protease-activated receptor 3, member of the class A family of seven-transmembrane G ...
122-412 1.25e-06

protease-activated receptor 3, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320493 [Multi-domain]  Cd Length: 274  Bit Score: 50.56  E-value: 1.25e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 122 VYVLAVMALFSLlgNLLTIWNIYktrisrRNSRHTWSAIYSLmfHLSIADVLvtwFCIIGEAAWCYTV---QWLANELTC 198
Cdd:cd15371    6 VYIIVVVLGVPS--NAIILWMLF------FRLRSVCTAIFYA--NLAISDLL---FCITLPFKIVYHLngnNWVFGETMC 72
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 199 KLVKLFQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLNMAKRCHRLLGGTYILSLVL--SLPqFFIfhVARGPFVEEFYQC 276
Cdd:cd15371   73 RIITITFYGNMYCSILLLTCISINRYLAIVHPFIYRSLPKKTYAVLICALVWTIVFlyMLP-FFI--LKQTYYLKELNIT 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 277 VTHGFYTADWQEQ----MYATFTLVFTFLLPLCILFGTYMSTFRTIsssekmfqgsklanystaklpTQTNRQRLIHkak 352
Cdd:cd15371  150 TCHDVLPECEQNSnfqfYYFISMAVFGFLIPLVITIFCYISIIRTL---------------------NAYEHKWFWY--- 205
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 442631927 353 mksLRISVVIIIAFLICWTPYYVMMIMFMFlNPDKRLGDDLqdaIFFFGMS------NSLVNPLIY 412
Cdd:cd15371  206 ---VKITALVLIIFTICFAPSNVILIIHHF-NYYYFNNDNL---YSIYLIAlclgslNSCLDPFLY 264
7tmA_VA_opsin cd15082
non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane ...
281-412 1.25e-06

non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The vertebrate ancient (VA) opsin photopigments were originally identified in salmon and they appear to have diverged early in the evolution of vertebrate opsins. VA opsins are localized in the inner retina and the brain in teleosts. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extraretinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity, and body color change. The VA opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320210 [Multi-domain]  Cd Length: 291  Bit Score: 50.57  E-value: 1.25e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 281 FYTADWQEQMYATFTLVFTFLLPLCILFGTYMSTFRtisssekmfqgsKLANYSTAKLPTQTNRqrlihKAKMKSLRISV 360
Cdd:cd15082  167 WYSGNMHDHTYIITFFTTCFILPLGVIFVSYGKLLQ------------KLRKVSNTQGRLGNAR-----KPERQVTRMVV 229
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 442631927 361 VIIIAFLICWTPYYVMMIMFMFLnPDKRLGDDLQDAIFFFGMSNSLVNPLIY 412
Cdd:cd15082  230 VMIVAFMVCWTPYAAFSILVTAH-PTIHLDPRLAAIPAFFSKTAAVYNPIIY 280
7tmA_OXGR1 cd15375
2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G ...
123-376 1.32e-06

2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; 2-oxoglutarate receptor 1 (OXGR1) is also known as GPR80, GPR99, or P2Y15. OXGR1 functions as a receptor for alpha-ketoglutarate, a citric acid cycle intermediate, and acts exclusively through a G(q)-dependent pathway. OXGR1 belongs to the class A GPCR superfamily and is phylogenetically related to the purinergic P2Y1-like receptor subfamily, whose members are coupled to G(q) protein to activate phospholipase C (PLC). OXGR1 has also been reported as a potential third cysteinyl leukotriene receptor with specificity for leukotriene E4.


Pssm-ID: 320497 [Multi-domain]  Cd Length: 280  Bit Score: 50.46  E-value: 1.32e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 123 YVLAVM--ALF--SLLGNLLTIWnIYKTRIsrrnsrHTWSAIYSLMFHLSIADVL-------VTWFCIIGEAawcytvqW 191
Cdd:cd15375    1 YYLPVMysIIFivGFPGNIIAIF-VYLFKM------RPWKSSTIIMLNLALTDLLyvtslpfLIYYYINGES-------W 66
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 192 LANELTCKLVKLFQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLNMAKRCHRLLGGT--YILSLVLSLPQFFIFHVargpf 269
Cdd:cd15375   67 IFGEFMCKFIRFIFHFNLYGSILFLTCFSIFRYVVIVHPLRAFQVQKRRWAIVACAvvWVISLAEVSPMTFLITT----- 141
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 270 VEEFYQCVTHGFYTADWQEQM--YATFTLVFTFLLPLCILFGTYMSTFRTISSSEKMfqgsklanySTAKlptqtnrqrl 347
Cdd:cd15375  142 KEKNNRTICLDFTSSDNLNTIwwYNWILTVLGFLLPLVIVTLCYTRIIYTLAKGPHT---------GSAS---------- 202
                        250       260
                 ....*....|....*....|....*....
gi 442631927 348 ihkaKMKSLRISVVIIIAFLICWTPYYVM 376
Cdd:cd15375  203 ----KQKARRLIILILLVFYVCFLPFHIL 227
7tmA_Parietopsin cd15085
non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled ...
123-412 1.47e-06

non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Parietopsin is a non-visual green light-sensitive opsin that was initially identified in the parietal eye of lizards. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Parietopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320213 [Multi-domain]  Cd Length: 280  Bit Score: 50.24  E-value: 1.47e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 123 YVLAVMALFSLLGNLLTIWNIYKtrisrrnSRHTWSAIYSLMFHLSIADVLVTWFCIIGEAAWCYTVQWLANELTCklvk 202
Cdd:cd15085    5 FLMFLNATFSIFNNVLVIAVTLK-------NPQLRNPINIFILNLSFSDLMMALCGTTIVTVTNYEGYFYLGDAFC---- 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 203 LFQMFSL----YLSTYVLVLIGVDRWIAVKYPMKSLNMA-KRCHRLLGGTYILSLVLSLPQFFIFHvARGPfvEEFYQCV 277
Cdd:cd15085   74 IFQGFAVnyfgIVSLWSLTLLAYERYNVVCKPMGGLKLStKRGYQGLLFIWLFCLFWAVAPLFGWS-SYGP--EGVQTSC 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 278 THGFYTADWQEQMYATFTLVFTFLLPLCILFGTYMSTFRTISSsekmfqgsklANYSTAKLPTQTNRQRLIHkakmkSLR 357
Cdd:cd15085  151 SIGWEERSWSNYSYLILYFLMCFVIPVAIIGFSYGNVLRSLHK----------LNKKIEQQGGKNCPEEEER-----AVI 215
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 442631927 358 ISVVIIIAFLICWTPYYVMMIMFMFlNPDKRLGDDLQDAIFFFGMSNSLVNPLIY 412
Cdd:cd15085  216 MVLAMVIAFLICWLPYTVFALIVVV-NPELSISPLAATMPTYFAKTSPVYNPIIY 269
7tmA_NAGly_R_GPR18 cd15166
N-arachidonyl glycine receptor, GPR18, member of the class A family of seven-transmembrane G ...
190-386 1.51e-06

N-arachidonyl glycine receptor, GPR18, member of the class A family of seven-transmembrane G protein-coupled receptors; N-arachidonyl glycine (NAGly), an endogenous metabolite of the endocannabinoid anandamide, has been identified as an endogenous ligand of the G(i/o) protein-coupled receptor 18 (GPR18). NAGly is involved in directing microglial migration in the CNS through activation of GPR18. NAGly-GPR18 signaling is thought to play an important role in microglial-neuronal communication. Recent studies also show that GPR18 functions as the abnormal cannabidiol (Abn-CBD) receptor. Abn-CBD is a synthetic isomer of cannabidiol and is inactive at cannabinoid receptors (CB1 or CB2), but acts as a selective agonist at GPR18. The NAGly receptor is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320294 [Multi-domain]  Cd Length: 275  Bit Score: 50.21  E-value: 1.51e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 190 QWLANELTCKLVKLFQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLNMAKRCHRLL--GGTYILSLVLSLPQFFIFhvARG 267
Cdd:cd15166   64 EWPFGDYFCRILGALTVFYPSIALWLLAFISADRYMAIVQPKHAKELKNTPKAVLacVGVWIMTLASTFPLLFLY--EDP 141
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 268 PFVEEFYQCVTHGFYTADWQEQMYATFTLVFTFLLPLCILFGTYMSTFRTisssekmfqgskLANYSTAKLPTqtnrqrl 347
Cdd:cd15166  142 DKASNFTTCLKMLDIIHLKEVNVLNFTRLIFFFLIPLFIMIGCYLVIIHN------------LVHGRTSKLKP------- 202
                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 442631927 348 ihKAKMKSLRISVVIIIAFLICWTPYYVMMIMFMFLNPD 386
Cdd:cd15166  203 --KVKEKSIRIIITLIVQVLVCFVPFHICFAFLMLQNGD 239
7tmA_NTSR2 cd15356
neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G ...
124-414 1.63e-06

neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320478 [Multi-domain]  Cd Length: 285  Bit Score: 50.25  E-value: 1.63e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 124 VLAVMALFSLLGNLLTIWNIYKtrisRRNSRHTWSAIYSLMFHLSIADVLVTWFCIIGEA---AWcYTVQWLANELTCKL 200
Cdd:cd15356    6 VYALIWALGAAGNALTIHLVLK----KRSLRGLQGTVHYHLVSLALSDLLILLISVPIELynfVW-FHYPWVFGDLVCRG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 201 VKLFQMFSLYLSTYVLVLIGVDRWIAVKYPM--KSLNMAKRCHRLLGGTYILSLVLSLPQFFIFHVargpfveefyqcvT 278
Cdd:cd15356   81 YYFVRDICSYATVLNIASLSAERYLAICQPLraKRLLSKRRTKWLLALIWASSLGFALPMAFIMGQ-------------K 147
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 279 HGFYTADWQEQMYATF--TLVFTFLLPLCILFGTYMSTFRTISSSEKMfqgsklaNYSTAklptqtnrQRLIHKAKMKSL 356
Cdd:cd15356  148 YELETADGEPEPSSRVctVLVSRATLKVFIQVNAFVSFVLPLALIAFL-------NGVTV--------SHLRIQSLQHSV 212
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 442631927 357 RISVVIIIAFLICWTPYYVMMIMFMFLnPDKRLGDDLQDAIFFFGM-SNSL------VNPLIYGA 414
Cdd:cd15356  213 QVLRAIVIAYVICWLPYHARRLMFCYV-PDDAWTDSLYNFYHYFYMlTNTLfyvssaVNPLLYNV 276
7tmA_P2Y11 cd15376
P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled ...
124-414 1.75e-06

P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y11 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. The activation of P2Y11 is a major pathway of macrophage activation that leads to the release of cytokines. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320498 [Multi-domain]  Cd Length: 284  Bit Score: 50.08  E-value: 1.75e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 124 VLAVMALFSLLGNLLTIWNIYkTRiSRRNsRHTwSAIYSlmFHLSIADVLVTwFCIIGEAAWCYTVQ-WLANELTCKLVK 202
Cdd:cd15376    6 ILGVEFLVAVLGNGLALWLFV-TR-ERRP-WHT-GVVFS--FNLAVSDLLYA-LSLPLLAAYYYPPKnWRFGEAACKLER 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 203 LFQMFSLYLSTYVLVLIGVDRWIAVKYPM--KSLNMAKRCHRLLGGTYILSLVLSLPQFFIFHVARGPfvEEFYQCVthG 280
Cdd:cd15376   79 FLFTCNLYGSIFFITCISLNRYLGIVHPFftRSHVRPKHAKLVSLAVWLLVAALSAPVLSFSHLEVER--HNKTECL--G 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 281 FYTADWQEQM--YATFTLVFTFLLPLCILFGTYMSTFRTISSSEKMfqgsklanystaklptqTNRQRLihkaKMKSLRI 358
Cdd:cd15376  155 TAVDSRLPTYlpYSLFLAVVGCGLPFLLTLASYLAIVWAVLRSPGI-----------------TTLEKR----KVAALVA 213
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 442631927 359 SVVIIIAflICWTPYYVMMImfmfLNPDKRLGDDLQDA---IFF-FGMSNSLVN------PLIYGA 414
Cdd:cd15376  214 VVVALYA--VSFVPYHILRN----LNLYRRLQWLKAAAslrIYFaYQVTKGLVTlnmcihPLLYMA 273
7tmA_NMU-R1 cd15358
neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G ...
134-412 2.32e-06

neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320480 [Multi-domain]  Cd Length: 305  Bit Score: 49.77  E-value: 2.32e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 134 LGNLLTIWNIYKTRISRrnsrhTWSAIYslMFHLSIADVLVTwfcIIGEAAWCYTVQ----WLANELTCKLVKLFQMFSL 209
Cdd:cd15358   16 VGNGLTCIVILRHKVMR-----TPTNYY--LFSLAVSDLLVL---LLGMPLELYEMWsnypFLLGAGGCYFKTLLFETVC 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 210 YLSTYVLVLIGVDRWIAVKYPMKSLNMAKRCH--RLLGGTYILSLVLSLPQ-----FFIFHVARGPFVEEFYQCVTHGfy 282
Cdd:cd15358   86 FASILNVTALSVERYIAVVHPLKAKYVVTRTHakRVIGAVWVVSILCSIPNtslhgIFQLTVPCRGPVPDSATCMLVK-- 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 283 tADWQEQMYATFTLVFTFLLPLCILFGTYMSTFRTIsSSEKMFQ------GSKLANYSTAKLPTQTNRQRLIHKakmksl 356
Cdd:cd15358  164 -PRWMYNLIIQITTLLFFFLPMGTISVLYLLIGLQL-KREKMLLvleakgSKAGDSYQHRRIQQEKRRRRQVTK------ 235
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 442631927 357 rISVVIIIAFLICWTPYYVMMIMFMFLNP-DKRLGDDLQ-----DAIFFFgmSNSLVNPLIY 412
Cdd:cd15358  236 -MLFVLVVVFGICWAPFHTDRLMWSFISQwTGELHLAFQyvhiiSGVFFY--LSSAANPVLY 294
7tmA_5-HT2_insect-like cd15307
serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane ...
216-416 2.32e-06

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320433 [Multi-domain]  Cd Length: 279  Bit Score: 49.57  E-value: 2.32e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 216 LVLIGVDRWIAVKYPMKSLNMAKRCHRLLGGTYI--LSLVLSLPQFFIFhvargpfVEEFYQCVTHGfyTADWQEQMYAT 293
Cdd:cd15307   91 LCTISVDRYLSLRYPMRFGRNKTRRRVTLKIVFVwlLSIAMSLPLSLMY-------SKDHASVLVNG--TCQIPDPVYKL 161
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 294 FTLVFTFLLPLCILFGTYMSTFRTISSSEKmfqgsklanystaklptqtnRQRLIHKAKMKSLRISVVIIIAFLICWTPY 373
Cdd:cd15307  162 VGSIVCFYIPLGVMLLTYCLTVRLLARQRS--------------------RHGRIIRLEQKATKVLGVVFFTFVILWSPF 221
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 442631927 374 YVMMIMFMF-LNPDKRLGDDLQDAIFFFGMSNSLVNPLIYGAFH 416
Cdd:cd15307  222 FVLNLLPTVcAECEERISHWVFDVVTWLGYASSMVNPIFYTIFN 265
7tmA_Histamine_H3R cd15296
histamine receptor subtypes H3R and H3R-like, member of the class A family of ...
124-416 2.65e-06

histamine receptor subtypes H3R and H3R-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H3R-like, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320423 [Multi-domain]  Cd Length: 271  Bit Score: 49.40  E-value: 2.65e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 124 VLAVMALFSLLGNLLTIWNIYKTRISRRNSRHtwsaiysLMFHLSIADVLVTWFCIIGEAAWCYTVQWLANELTCKLVKL 203
Cdd:cd15296    6 LMALLVVATVLGNALVILAFVVDSSLRTQGNF-------FFLNLAISDFLVGGFCIPLYIPYVLTGRWKFGRGLCKLWLV 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 204 FQMFSLYLSTYVLVLIGVDRWI----AVKYPMKSlNMAKRCHRLLGGTYILSLVLSLPQFFIF-HVARGPFVEEfYQCVT 278
Cdd:cd15296   79 VDYLLCTASVFNIVLISYDRFLsvtrAVSYRAQK-GMTRQAVLKMVLVWVLAFLLYGPAIISWeYIAGGSIIPE-GECYA 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 279 HGFYTadWQEQMYATftlVFTFLLPLCILFGTYMSTFRTIsssekmfqgsklanystaklptQTNRQRLIHKAKM-KSLr 357
Cdd:cd15296  157 EFFYN--WYFLMTAS---TLEFFTPFISVTYFNLSIYLNI----------------------QKRRFRLSRDKKVaKSL- 208
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 442631927 358 isVVIIIAFLICWTPYYVMMIMFMFLNpDKRLGDDLQDAIFFFGMSNSLVNPLIYGAFH 416
Cdd:cd15296  209 --AIIVCVFGLCWAPYTLLMIIRAACH-GHCVPDYWYETSFWLLWVNSAINPVLYPLCH 264
7tmA_NPY5R cd15398
neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G ...
126-325 2.75e-06

neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320520 [Multi-domain]  Cd Length: 273  Bit Score: 49.38  E-value: 2.75e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 126 AVMALFSLLGNLLTIWNIYKTRISRrnsrhtwSAIYSLMFHLSIADVLVTWFCIIGEAAWCYTVQWLANELTCKLVKLFQ 205
Cdd:cd15398    8 TFISLLGFLGNLLILTALTKKWKQK-------TIINFLIGNLAFSDILVVLFCSPFTLTCVLLDQWIFGEVMCHIVPFLQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 206 MFSLYLSTYVLVLIGVDRWIAVKYPMKSLNMAKRCHRLLGGTYILSLVLSLPqFFIFH-------VARGPFVEEFYQCVt 278
Cdd:cd15398   81 CVSVMVSTLMLMSIAIVRYHMIKHPLSNHLTANHGYFLLGTVWTLGFTICSP-LPVFHkivdlseTFNLESLKNKYLCI- 158
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 442631927 279 hgfytADWQEQMYAT-FT---LVFTFLLPLCILFGTYMSTFRTISSSEKMF 325
Cdd:cd15398  159 -----ESWPSDSYRIaFTislLFVQYILPLVCLTVSHTSVCRSVKRSRSVF 204
7tmA_TAAR6_8_9 cd15316
trace amine-associated receptors 6, 8, and 9, member of the class A family of ...
124-416 3.59e-06

trace amine-associated receptors 6, 8, and 9, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320439 [Multi-domain]  Cd Length: 290  Bit Score: 49.09  E-value: 3.59e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 124 VLAVMALFSLLGNLLTIwniyktrISRRNSRHTWSAIYSLMFHLSIAD----VLVTWFCIIGEAAWCytvqWLANELTCK 199
Cdd:cd15316    6 VLGFGAVLAVFGNLLVM-------ISILHFKQLHSPTNFLIASLACADflvgVTVMPFSTVRSVESC----WYFGESFCT 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 200 LVKLFQMFSLYLSTYVLVLIGVDRWIAVK----YPMK-SLNMAKRCHRLlggTYILSLVLSLPQFFIFHVARGpfVEEFY 274
Cdd:cd15316   75 FHTCCDVSFCYASLFHLCFISVDRYIAVTdplvYPTKfTVSVSGICISV---SWIFSLTYSFSVFYTGVNDDG--LEELV 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 275 QCVT--HGFYTADWQEQMYATFTLVFTFLLPLCILFGTYMSTFRTisssekmfQGSKLANYSTAKLPTQTNRQRLIHKAK 352
Cdd:cd15316  150 NALNcvGGCQIILNQNWVLVDFLLFFIPTFAMIILYGKIFLVAKQ--------QARKIEMTSSKAESSSESYKDRVARRE 221
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 442631927 353 MKSLRISVVIIIAFLICWTPYYVMMIM--FM-FLNPDKrlgddLQDAIFFFGMSNSLVNPLIYGAFH 416
Cdd:cd15316  222 RKAAKTLGITVIAFLVSWLPYLIDVLIdaFMnFITPPY-----IYEICCWCAYYNSAMNPLIYALFY 283
7tmA_D3_dopamine_R cd15310
D3 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
123-417 4.20e-06

D3 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320436 [Multi-domain]  Cd Length: 259  Bit Score: 48.81  E-value: 4.20e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 123 YVLAVMALfsLLGNLLTIWNIYKTRISRRNSRHtwsaiysLMFHLSIADVLVTWFCIigeaAWCYTVQ-----WLANELT 197
Cdd:cd15310    7 YCALILAI--VFGNVLVCMAVLRERALQTTTNY-------LVVSLAVADLLVATLVM----PWVVYLEvtggvWNFSRIC 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 198 CKLVKLFQMFSLYLSTYVLVLIGVDRWIAVKYPMK-----SLNMAKRCHRLLGGTYILSLVLSLPQFFIFHVARGPFVee 272
Cdd:cd15310   74 CDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHyqhgtGQSSCRRVSLMITAVWVLAFAVSCPLLFGFNTTGDPTV-- 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 273 fyqcvthgfytADWQEQMYATFTLVFTFLLPLCILFGTYMSTFRTISSSEKMFQgsklanystaklptqtnrqrlihkak 352
Cdd:cd15310  152 -----------CSISNPDFVIYSSVVSFYLPFGVTLLVYVRIYVVLLREKKATQ-------------------------- 194
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 442631927 353 mkslrISVVIIIAFLICWTPYYVMMIMFMFLnPDKRLGDDLQDAIFFFGMSNSLVNPLIYGAFHL 417
Cdd:cd15310  195 -----MLAIVLGAFIVCWLPFFLTHILNTHC-QACHVPPELYSATTWLGYVNSALNPVIYTTFNI 253
7tmA_P2Y4 cd15374
P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled ...
157-375 4.38e-06

P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y4 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. This family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320496 [Multi-domain]  Cd Length: 285  Bit Score: 49.03  E-value: 4.38e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 157 WSAIYSLMFHLSIADVLVTWFCIIGEAAWCYTVQWLANELTCKLVKLFQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLNM 236
Cdd:cd15374   32 WNPTTVYMFHLALSDTLYVLSLPTLIYYYADHNHWPFGVVACKIVRFLFYANLYCSILFLTCISVHRYVGICHPIRALRW 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 237 AKRCH-RLLGGTYILSLVLSLPQFFIF------------HVARGPfvEEFYQCVThgfytadwqeqmYATFTLVFTFLLP 303
Cdd:cd15374  112 VKPRHaYLICASVWLVVTVCLVPNLIFvttsrkdnitlcHDTTRP--EEFDHYVH------------YSSAVMVLLFGIP 177
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 442631927 304 LCILFGTYMSTFRTISSsekmfqgsklanystaklPTQTNRQRLIHKAKMKSLRISVVIIIAFLICWTPYYV 375
Cdd:cd15374  178 CLVIVVCYGLMARRLCK------------------PRVGSSRQQGPSSKKRSLKTIIMVLTVFAICFVPFHI 231
7tmA_GPR63 cd15404
G protein-coupled receptor 63, member of the class A family of seven-transmembrane G ...
122-412 4.67e-06

G protein-coupled receptor 63, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the human orphan receptor GPR63, which is also called PSP24-beta or PSP24-2, and its closely related proteins found in vertebrates. GPR63 shares the highest sequence homology with GPR45 (Xenopus PSP24, mammalian PSP24-alpha or PSP24-1). PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Mammalian PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320526 [Multi-domain]  Cd Length: 265  Bit Score: 48.68  E-value: 4.67e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 122 VYVLAVMALFSLLGNLLTIWNIYKTRISRrnsrhtwSAIYSLMFHLSIADVLVTWFCIIGEAAWCYTVQWLANELTCKLV 201
Cdd:cd15404    4 SAVMIFILLVSFLGNFVVCLMVYQKAAMR-------SAINILLASLAFADMMLAVLNMPFALVTIITTRWIFGDAFCRVS 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 202 KLFQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLNmAKRCHRLLGGTYILSLVLSLPQFF---IFHV-ARGPfveefyQCV 277
Cdd:cd15404   77 AMFFWLFVMEGVAILLIISIDRFLIIVQKQDKLN-PYRAKVLIAVSWAVSFCVAFPLAVgspDLQIpSRAP------QCV 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 278 THgfYTADWQEQMYATFTLVFTFLLPLCILFGTYMSTFRTISSsekmfqgsklanystaklptqtnrqrlihkAKMKSLR 357
Cdd:cd15404  150 FG--YTTNPGYQAYVILIMLIFFFIPFMVMLYSFMGILNTVRS------------------------------FKTRAFT 197
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 442631927 358 ISVVIIIAFLICWTPYYVMMIMFMFlnpdkrlGDDLQDAIFFFGMSN---------SLVNPLIY 412
Cdd:cd15404  198 TILILFIVFTVCWAPFTTYSLVATF-------NSHFYHKHNFFEISTwllwlcylkSALNPLIY 254
7tmA_CysLTR cd15921
cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G ...
124-412 4.85e-06

cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320587 [Multi-domain]  Cd Length: 283  Bit Score: 48.65  E-value: 4.85e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 124 VLAVMALFSLLGNLLTIWNIYKTRisrrnsrHTWSAIYSLMFHLSIADVLVTWFCIIGEAAWCYTVQWLANELTCKLVKL 203
Cdd:cd15921    6 AYILIFILGLTGNSISVYVFLSQY-------RSQTPVSVLMVNLAISDLLLVCTLPLRLTYYVLNSHWPFGDIACRIILY 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 204 FQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLNMA--KRCHRLLGGTYILSLVLSLPQFFifhVARGPFVEEFYQCVTHGF 281
Cdd:cd15921   79 VLYVNMYSSIYFLTALSVFRYLALVWPYLYLRVQthSVAGIICGLIWILMGLASSPLLF---AKSKQHDEGSTRCLELAH 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 282 YTADWQEQMYaTFTLVFTFLLPLCILFGTYMSTFRTIsssekmfqgsklanystAKLPTQTNRQRLIHKakmKSLRISVV 361
Cdd:cd15921  156 DAVDKLLLIN-YVTLPVGFVVPFMTVIFCYIFIIKNL-----------------LKPSPALGRTRPSRR---KACALIII 214
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 442631927 362 IIIAFLICWTPYYVMMIMFMFL-NPDKRLGD---DLQDAIFF---FGMSNSLVNPLIY 412
Cdd:cd15921  215 SLGIFLVCFLPYHIVRTIHLITeRQIKESCGyilRVRKAAVItlcLAASNSCFDPLLY 272
7tmA_GPR15 cd15194
G protein-coupled receptor 15, member of the class A family of seven-transmembrane G ...
118-415 5.60e-06

G protein-coupled receptor 15, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR15, also called as Brother of Bonzo (BOB), is an orphan G-protein coupled receptor that was originally identified as a co-receptor for human immunodeficiency virus. GPR15 is upregulated in patients with rheumatoid arthritis and shares high sequence homology with angiotensin II type AT1 and AT2 receptors; however, its endogenous ligand is unknown. GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation.


Pssm-ID: 320322 [Multi-domain]  Cd Length: 281  Bit Score: 48.70  E-value: 5.60e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 118 GLLKVYVLAVMaLFSLLGNLLTIWNIYKTRISRRnsrhtwsAIYSLMFHLSIADV--LVTWFCIIGEAAWCYTvqWLANE 195
Cdd:cd15194    1 GFLPILYCLVF-LVGAVGNAILMGALVFKRGVRR-------LIDIFISNLAASDFifLVTLPLWVDKEVVLGP--WRSGS 70
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 196 LTCKLVKLFQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLNMAKR--CHRLLGGTYILSLVLSLPqffIFHVARGPFVEEF 273
Cdd:cd15194   71 FLCKGSSYIISVNMYCSVFLLTCMSLDRYLAIVLPLVSRKFRTKhnAKVCCTCVWMLSCLLGLP---TLLSRELKKYEEK 147
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 274 YQCVTHGFYTAdwqEQMYATFTLVFTFLLPLCILFGTYMSTFRtisssekmfqgsklanystaKLPTQTNRQRLIHKAKM 353
Cdd:cd15194  148 EYCNEDAGTPS---KVIFSLVSLIVAFFLPLLSILTCYCTIIW--------------------KLCHHYQKSGKHQKKLR 204
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 442631927 354 KSLRISVVIIIAFLICWTPYYVmmimFMFLNPDKRLGDD---LQDAIFFFGM--------SNSLVNPLIYGAF 415
Cdd:cd15194  205 KSIKIVFIVVAAFVFSWMPFNL----FKALAIASGLQVEvtcLPYTLAQLGMevsaplafANSCANPFIYYFF 273
7tmA_PD2R2_CRTH2 cd15118
prostaglandin D2 receptor, member of the class A family of seven-transmembrane G ...
127-412 5.61e-06

prostaglandin D2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. PD2R2 is involved in mediating chemotaxis of Th2 cells, eosinophils, and basophils generated during allergic inflammatory processes. CRTH2 (PD2R2), but not DP receptor, undergoes agonist-induced internalization which is one of key processes that regulates the signaling of the GPCR.


Pssm-ID: 320246 [Multi-domain]  Cd Length: 284  Bit Score: 48.65  E-value: 5.61e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 127 VMALFSLLGNLLTIWNI-YKTRisrRNSRHTWsaiyslMFHLSIADVLV-------TWFCIIGEAawcytvqWLANELTC 198
Cdd:cd15118    9 IVSTLGIVENLLILWVVgFRLR---RTVISIW------ILNLALSDLLAtlslpffTYYLASGHT-------WELGTTFC 72
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 199 KLVKLFQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLN--MAKRCHRLLGGTYILSLVLSLPQFFI--------------F 262
Cdd:cd15118   73 RIHSSIFFLNMFVSGFLLAAISLDRCLLVVKPVWAQNhrNVAAAKKICGVIWAMALINTIPYFVFrdvierkdgrklcyY 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 263 HVARgpFVEEFYQCVTHgfyTADWQEQMyATFTLVFTFLLPLCILFGTYMStfrtISSsekmfqgsklanystaklptqt 342
Cdd:cd15118  153 NFAL--FSPSPDNNHPI---CKQRQEGL-AISKLLLAFLIPLVIIAVSYAV----VSL---------------------- 200
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 442631927 343 nrqRLIHKAKMKS---LRISVVIIIAFLICWTPYYVMMIMFMFLNPDKRLGDDLQDAIFF---FGMSNSLVNPLIY 412
Cdd:cd15118  201 ---IIRHRCRRRPgrfVRLVVSVVVSFALCWAPYHIFSIIEVMAHNQHSLRPLVIQGLPFattLAFLNSVLNPVLY 273
7tmA_AstC_insect cd15094
somatostatin-like receptor for allatostatin C, member of the class A family of ...
119-415 6.20e-06

somatostatin-like receptor for allatostatin C, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. In Drosophila melanogaster and other insects, a 15-amino-acid peptide named allatostatin C(AstC) binds the somatostatin-like receptors. Two AstC receptors have been identified in Drosophila with strong sequence homology to human somatostatin and opioid receptors.


Pssm-ID: 320222 [Multi-domain]  Cd Length: 282  Bit Score: 48.24  E-value: 6.20e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 119 LLKVYVLAVMALFSLLGNLLTIWniyktRISRRNSRHTWSAIYslMFHLSIADVLVtwfcIIGEAAWCYTV---QWLANE 195
Cdd:cd15094    1 LISAVLYGLICIVGLVGNGLVIY-----VVLRYAKMKTVTNLY--ILNLAVADECF----LIGLPFLIVTMilkYWPFGA 69
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 196 LTCKLVKLFQMFSLYLSTYVLVLIGVDRWIAVKYPMKS-----LNMAKRCHRLlggTYILSLVLSLPqffIFHVARGPFV 270
Cdd:cd15094   70 AMCKIYMVLTSINQFTSSFTLTVMSADRYLAVCHPIRSmryrtPFIAKVVCAT---TWSISFLVMLP---IILYASTVPD 143
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 271 EEFYQCvthgfyTADWQEQMY----ATFTLvFTFLL----PLCILFGTYMSTFRTISssekmfqgsklanysTAKLPTQT 342
Cdd:cd15094  144 SGRYSC------TIVWPDSSAvngqKAFTL-YTFLLgfaiPLLLISVFYTLVILRLR---------------TVGPKNKS 201
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 442631927 343 NRQRLIHKakmKSLRISVVIIIAFLICWTPYYVMMIMFMFLNPDKRLgDDLQDAIF----FFGMSNSLVNPLIYgAF 415
Cdd:cd15094  202 KEKRRSHR---KVTRLVLTVISVYIICWLPYWAFQVHLIFLPPGTDM-PKWEILMFllltVLSYANSMVNPLLY-AF 273
7tmA_PAFR cd15147
platelet-activating factor receptor, member of the class A family of seven-transmembrane G ...
124-375 6.54e-06

platelet-activating factor receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The platelet-activating factor receptor is a G(q/11)-protein coupled receptor, which is linked to p38 MAPK and PI3K signaling pathways. PAF is a phospholipid (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) which is synthesized by cells especially involved in host defense such as platelets, macrophages, neutrophils, and monocytes. PAF is well-known for its ability to induce platelet aggregation and anaphylaxis, and also plays important roles in allergy, asthma, and inflammatory responses, among many others.


Pssm-ID: 320275 [Multi-domain]  Cd Length: 291  Bit Score: 48.21  E-value: 6.54e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 124 VLAVMALFSLLGNLLTIWNIYKTRISRRnsrhtWSAIYSLMFHLSIADVLVtwfcIIGEAAW----CYTVQWLANELTCK 199
Cdd:cd15147    6 VYSIIFVLGLIANCYVLWVFARLYPSKK-----LNEIKIFMVNLTIADLLF----LITLPFWivyyHNEGNWILPKFLCN 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 200 LVKLFQMFSLYLSTYVLVLIGVDRWIAVKYPMKSlnmAKRCHRLLGgtYILSLVL-------SLPQFF---IFHVARGpf 269
Cdd:cd15147   77 VAGCLFFINTYCSVAFLGVISYNRYQAVTRPIKT---AQSTTRKRG--IIISVAIwviivasASYFLFmdsTNTVKID-- 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 270 VEEFYQCVTHgfYTADWQEQMYAT-FTLVFTFLLPLCILFGTYMSTFRTISSsekmfqgsklanystaklptQTNRQRLI 348
Cdd:cd15147  150 SGNFTRCFEG--YEKDNSKPVLIIhFIIIGLFFLVFLLILVCNLVIARTLLS--------------------QPVQGQRN 207
                        250       260
                 ....*....|....*....|....*..
gi 442631927 349 HKAKMKSLRISVVIIIAFLICWTPYYV 375
Cdd:cd15147  208 AGVKRRALWMVCTVLAVFVICFVPHHV 234
7tmA_GPR65_TDAG8 cd15365
proton-sensing G protein-coupled receptor 65, member of the class A family of ...
159-393 6.90e-06

proton-sensing G protein-coupled receptor 65, member of the class A family of seven-transmembrane G protein-coupled receptors; The T cell death associated gene-8 receptor (TDAG8, also known as GPR65) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. Activation of TDAG8 by extracellular acidosis increases the cAMP production, stimulates Rho, and induces stress fiber formation. TDAG8 has also been shown to regulate the extracellular acidosis-induced inhibition of pro-inflammatory cytokine production in peritoneal macrophages.


Pssm-ID: 320487 [Multi-domain]  Cd Length: 277  Bit Score: 48.24  E-value: 6.90e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 159 AIYslMFHLSIADVLVTwfciIGEAAWCYTV----QWLANELTCKLVKLFQMFSLYLSTYVLVLIGVDRWIAVKYPMKSL 234
Cdd:cd15365   36 GVY--LFNLSLSDLLYI----VILPLWIDYLwngdNWTLSGFVCIFSAFLLYTNFYTSTALLTCIALDRYLAVVHPLKFM 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 235 NMAKRCHRLLGGTYILSLV-----LSLPQFFIFHVARGpfveeFYQCVtHGFYTADWQEQMyATFTLVFTFLLPLCILFG 309
Cdd:cd15365  110 HLRTIRTALSVSVAIWLLEicfnaVILTWEDSFHESSS-----HTLCY-DKFPLEDWQARL-NLFRICLGYLLPLLIILF 182
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 310 TYMSTFRTISSsekmfqgsklaNYSTAKlptqtnrqrlihKAKMKSLRISVVIIIAFLICWTPYYVMMIMFMFLNP-DKR 388
Cdd:cd15365  183 CYWKIYQAVRS-----------NQATED------------QEKKKIFKLLLLITVTFVICFTPYHVVLLIRSIVEPcDCR 239

                 ....*
gi 442631927 389 LGDDL 393
Cdd:cd15365  240 NAKWL 244
7tmA_CCR9 cd15174
CC chemokine receptor type 9, member of the class A family of seven-transmembrane G ...
130-379 7.56e-06

CC chemokine receptor type 9, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR9 is a homeostatic receptor specific for CCL25 (formerly known as thymus expressed chemokine) and is highly expressed on both immature and mature thymocytes as well as on intestinal homing T Lymphocytes and mucosal Lymphocytes. In cutaneous melanoma, activation of CCR9-CCL25 has been shown to stimulate metastasis to the small intestine. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 320302 [Multi-domain]  Cd Length: 280  Bit Score: 48.21  E-value: 7.56e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 130 LFSLLGNLLTIWnIYKTRISRRnsrhTWSAIYSLmfHLSIADVLvtWFCIIGEAAWCYTVQWLANELTCKLVKLFQMFSL 209
Cdd:cd15174   12 LVGAVGNSLVVL-IYTYYRRRK----TMTDVYLL--NLAIADLL--FLCTLPFWATAASSGWVFGTFLCKVVNSMYKINF 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 210 YLSTYVLVLIGVDRWIAVKYPMKSLNMAKRchRLLGG------TYILSLVLSLPQfFIFHVARgpfvEEFYQCVTHGFYT 283
Cdd:cd15174   83 YSCMLLLTCISVDRYIAIVQATKAHNSKNK--RLLYSklvcffVWLLSTILSLPE-ILFSQSK----EEESVTTCTMVYP 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 284 ADWQEQM-YATFTL--VFTFLLPLCILFGTYMSTFRTISSSeKMFQgsklanystaklptqtnrqrlihkaKMKSLRISV 360
Cdd:cd15174  156 SNESNRFkVAVLALkvTVGFFLPFVVMVICYTLIIHTLLQA-KRFQ-------------------------KHKALKVII 209
                        250
                 ....*....|....*....
gi 442631927 361 VIIIAFLICWTPYYVMMIM 379
Cdd:cd15174  210 AVVTVFVLSQLPYNSILLI 228
7tmA_GPR176 cd15006
orphan G protein-coupled receptor 176, member of the rhodopsin-like class A GPCR family; ...
132-412 8.00e-06

orphan G protein-coupled receptor 176, member of the rhodopsin-like class A GPCR family; GPR176 is a putative G protein-coupled receptor that belongs to the class A GPCR superfamily; no endogenous ligand for GPR176 has yet been identified. The class A rhodopsin-like GPCRs represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320135 [Multi-domain]  Cd Length: 289  Bit Score: 47.95  E-value: 8.00e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 132 SLLGNLLTIWNIYKTRISRrnsrhtwSAIYSLMFHLSIADVLVTWFCI---IGEAAWCYTVQWLANELTCKLVKLFQMFS 208
Cdd:cd15006   13 SLLGNFMVLWSTCRTSVFK-------SVTNRFIKNLACSGICASLVCVpfdIVLSASPHCCWWIYTLLFCKVIKFLHKVF 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 209 LYLSTYVLVLIGVDRWIAVKYPMKSLNMAKRCHRLLGGTYILSLVLSLPQFFIFHVArgpfveEFYQCVThgfYTADWQE 288
Cdd:cd15006   86 CSVTVLSFAAIALDRYYSVLYPLERKISDAKSRDLVIYIWAHAVVASVPVFAVTNVT------DIYAMST---CTESWGY 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 289 QM----YATFTLVFTFLLPLCILFGTYMSTFRTISSSE--KMFQGSKLANYSTAKLPTQTNRQrlihkAKMKSLRISVVI 362
Cdd:cd15006  157 SLghlvYVIIYNITTVILPVAVVFLFMILIRRALSASQkkKVIIAALRTPQNTISIPYVSQRE-----AELHAMLLSMVL 231
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 442631927 363 IiaFLICWTPYYVMMIMFMFLNPDKRLGDDLQDAIFFFGMSnSLVNPLIY 412
Cdd:cd15006  232 V--FILCSVPYATLVIYRTILNISDISVFLLLTAIWLPKVS-LLANPLLF 278
7tmA_alpha2A_AR cd15322
alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
122-416 1.43e-05

alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320445 [Multi-domain]  Cd Length: 259  Bit Score: 47.25  E-value: 1.43e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 122 VYVLAVMALFSLLGNLLTIWNIYKTRISRRNSRhtwsaiySLMFHLSIADVLVTWFCIIGEAAWCYTVQWLANELTCKLV 201
Cdd:cd15322    4 IILVGLLMLLTVFGNVLVIIAVFTSRALKAPQN-------LFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIY 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 202 KLFQMFSLYLSTYVLVLIGVDRWI----AVKYPMKslNMAKRCHRLLGGTYILSLVLSLPQFFIFHVARGPfvEEFYQCV 277
Cdd:cd15322   77 LALDVLFCTSSIVHLCAISLDRYWsitqAIEYNLK--RTPRRIKCIIFIVWVISAVISFPPLITIEKKSGQ--PEGPICK 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 278 THgfytadwQEQMYATFTLVFTFLLPLCILFGTYMSTFRTISSSEKMFQgsklanystaklptqtnrqrlihkakmkslR 357
Cdd:cd15322  153 IN-------DEKWYIISSCIGSFFAPCLIMVLVYIRIYQIAKNREKRFT------------------------------F 195
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 442631927 358 ISVVIIIAFLICWTPYYVMMIMFMFLnpDKRLGDDLQDAIFFFGMSNSLVNPLIYGAFH 416
Cdd:cd15322  196 VLAVVIGVFVICWFPFFFTYTLTAVC--DCSVPETLFKFFFWFGYCNSSLNPVIYTIFN 252
7tmA_Adenosine_R_A3 cd15070
adenosine receptor subtype A3, member of the class A family of seven-transmembrane G ...
126-412 1.62e-05

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G protein-coupled receptors; The A3 receptor, a member of the adenosine receptor family of G protein-coupled receptors, is coupled to G proteins of the inhibitory G(i) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels. The A3 receptor has a sustained protective function in the heart during cardiac ischemia and contributes to inhibition of neutrophil degranulation in neutrophil-mediated tissue injury. Moreover, activation of A3 receptor by adenosine protects astrocytes from cell death induced by hypoxia.


Pssm-ID: 320198 [Multi-domain]  Cd Length: 280  Bit Score: 47.08  E-value: 1.62e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 126 AVMALFSLLGNLLTIWNIyKTRISRRNSrhtwsaIYSLMFHLSIADVLVTWFCIigEAAWCYTVQWLANELTCKLVKLFQ 205
Cdd:cd15070    8 ILIGLCAVVGNVLVIWVV-KLNPSLRTT------TFYFIVSLALADIAVGVLVI--PLAIVVSLGVTIHFYSCLFMSCLL 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 206 MFSLYLSTYVLVLIGVDRWIAVKYPM--KSLNMAKRCHRLLGGTYILSLVLSLPQFFIFHVARgPFVEEFYQCVTHGFYT 283
Cdd:cd15070   79 VVFTHASIMSLLAIAVDRYLRVKLTVryRIVTTQRRIWLALGLCWLVSFLVGLTPMFGWNRKP-SLESVNTTPLQCQFTS 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 284 ADWQEQMyATFTLVFTFLLPLCILFGTYMSTFRTISssekmfqgSKLANYSTAKLPTQTNRQRLIHKAKMKSLrisvvII 363
Cdd:cd15070  158 VMRMDYM-VYFSFFTWILIPLVIMCALYVDIFYIIR--------NKLSQNATGFRETGAFYGREFKTAKSLAL-----VL 223
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 442631927 364 IAFLICWTPYYVMMIMFMFlNPdkrlgdDLQDAIFFFGM----SNSLVNPLIY 412
Cdd:cd15070  224 FLFAVCWLPLSIINCVVYF-NP------KVPKIALYLGIllshANSMMNPIVY 269
7tmA_Pinopsin cd15084
non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled ...
158-412 1.96e-05

non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Pinopsins are found in the pineal organ of birds, reptiles and amphibians, but are absent from teleosts and mammals. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Pinopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320212 [Multi-domain]  Cd Length: 295  Bit Score: 46.78  E-value: 1.96e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 158 SAIYSLMFHLSIADVLVTWFCIIGEAAWCYTVQWLANELTCKLVKLFQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLNMA 237
Cdd:cd15084   43 SPLNYILVNLAVADLLVTLFGSSVSFSNNIVGFFVFGKTMCEFEGFMVSLTGIVGLWSLAILAFERYLVICKPMGDFRFQ 122
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 238 KRcHRLLGG--TYILSLVLSLPQFFifhvARGPFVEE-FYQCVTHGFYTADWQEQMYATFTLVFTFLLPLCILFGTYMST 314
Cdd:cd15084  123 QR-HAVSGCafTWGWSLLWTSPPLF----GWSSYVPEgLRTSCGPNWYTGGTNNNSYILALFVTCFALPLSTIIFSYSNL 197
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 315 FRTISSsekmfqgsklanystakLPTQTNRQRLIHKAKMKSLRISVVIIIAFLICWTPYYVMMiMFMFLNPDKRLGDDLQ 394
Cdd:cd15084  198 LLTLRA-----------------VAAQQKESETTQRAEKEVTRMVIAMVMAFLICWLPYATFA-MVVATNKDVVIQPTLA 259
                        250
                 ....*....|....*...
gi 442631927 395 DAIFFFGMSNSLVNPLIY 412
Cdd:cd15084  260 SLPSYFSKTATVYNPIIY 277
7tmA_CCR1 cd15183
CC chemokine receptor type 1, member of the class A family of seven-transmembrane G ...
130-382 1.97e-05

CC chemokine receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR1 is widely expressed on both hematopoietic and non-hematopoietic cells and binds to the inflammatory CC chemokines CCL3, CCL5, CCL6, CCL9, CCL15, and CCL23. CCR1 activates the typical chemokine signaling pathway through the G(i/o) type of G proteins, causing inhibition of adenylate cyclase and stimulation of phospholipase C, PKC, calcium flux, and PLA2. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320311 [Multi-domain]  Cd Length: 278  Bit Score: 46.79  E-value: 1.97e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 130 LFSLLGNLLTIWNIYKTRISRrnsrhTWSAIYslMFHLSIADvLVTWFCIIGEAAWCYTVQWLANELTCKLVKLFQMFSL 209
Cdd:cd15183   12 IIGVVGNVLVVLVLIQHKRLR-----NMTSIY--LFNLAISD-LVFLFTLPFWIDYKLKDDWIFGDAMCKFLSGFYYLGL 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 210 YLSTYVLVLIGVDRWIAVKYPMKSLNMAKRCHRLLGG--TYILSLVLSLPQFFIFHvARGPFVeeFYQCVTHGFYTADWQ 287
Cdd:cd15183   84 YSEIFFIILLTIDRYLAIVHAVFALRARTVTFGIITSiiTWALAILASMPCLYFFK-SQWEFT--HHTCSAHFPRKSLIR 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 288 EQMYATFTL-VFTFLLPLCILFGTYMSTFRTIsssekmfqgsklanystaklptqtnrQRLIHKAKMKSLRISVVIIIAF 366
Cdd:cd15183  161 WKRFQALKLnLLGLILPLLVMIICYTGIINIL--------------------------LRRPNEKKAKAVRLIFVITLLF 214
                        250
                 ....*....|....*.
gi 442631927 367 LICWTPYYVMMIMFMF 382
Cdd:cd15183  215 FLLWTPYNLAAFVSAF 230
7tmA_GPR34-like cd15148
putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G ...
124-418 2.27e-05

putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 34 of unknown function. Orphan GPR34 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320276 [Multi-domain]  Cd Length: 282  Bit Score: 46.61  E-value: 2.27e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 124 VLAVMA----LFSLLGNLLTIWNIYKTRiSRRNSrhtwsaIYSLMFHLSIADVLVTwFCIIGEAAwcYTV---QWLANEL 196
Cdd:cd15148    2 PLAVFYslifLFGLVGNLLALWVFLFIH-RKRNS------VRIFLINVAIADLLLI-ICLPFRIL--YHVnnnQWTLGPL 71
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 197 TCKLV-KLFQMfSLYLSTYVLVLIGVDRWIAVKYPM--KSLNMAKRCHRLLGGTYILSLVLslpqfFIFHVARGPFVEEF 273
Cdd:cd15148   72 LCKVVgNLFYM-NMYISIILLGFISLDRYLKINRSSrrQKFLTRKWSIVACGVLWAVALVG-----FVPMIVLTEKNEES 145
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 274 YQCVTH-GFYTADWQEqmYATFTLVFTFLLPLCILFGTYmstfrtISSSEKMFQGSKlanySTAKLPTQTNRQRlihkak 352
Cdd:cd15148  146 TKCFQYkDRKNAKGKA--IFNFLIVAMFWLVFLLLILSY------GKIAKKLLRISR----DKPDFPNAAKYNR------ 207
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 442631927 353 mkSLRISVVIIIAFLICWTPYYVMMIMFMF--LNPD----KRLGDDLQDAIFFFGMSNSLVNPLIYgaFHLC 418
Cdd:cd15148  208 --TARKSFFVLFIFTVCFVPYHAFRIFYITsqLQNNscywKEILHKTNEIMLLLSAFNSCLDPVMY--FLLS 275
7tmA_ETBR-LP2 cd15126
endothelin B receptor-like protein 2, member of the class A family of seven-transmembrane G ...
158-268 2.66e-05

endothelin B receptor-like protein 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelin B receptor-like protein 2, also called GPR37L1, is almost exclusively expressed in the nervous system. It has recently been shown to act as a receptor for the neuropeptide prosaptide, the active fragment of the secreted neuroprotective and glioprotective factor prosaposin (also called sulfated glycoprotein-1). Both prosaptide and prosaposin protect primary astrocytes against oxidative stress. GPR37L1 is part of the class A family of GPCRs that includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320254  Cd Length: 298  Bit Score: 46.40  E-value: 2.66e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 158 SAIYSLMFHLSIADVLVTWFCIIGEAAWCYTVQWLANELTCKLVKLFQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLNMA 237
Cdd:cd15126   33 SAWNSILASLALWDFLVLFFCLPVVVFNEITKKRLLGDVSCRVVPYMEVTSLGVTTFSLCALGIDRFHAATSPQPKARPV 112
                         90       100       110
                 ....*....|....*....|....*....|....
gi 442631927 238 KRCHRLLGG---TYILSLVLSLPQFFIFHVARGP 268
Cdd:cd15126  113 ERCQSILAKlavIWVGSMTLAVPELLLWQLAQET 146
7TM_GPCR_Srw pfam10324
Serpentine type 7TM GPCR chemoreceptor Srw; Chemoreception is mediated in Caenorhabditis ...
127-260 2.75e-05

Serpentine type 7TM GPCR chemoreceptor Srw; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srw is a solo family amongst the superfamilies of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'. The genes encoding Srw do not appear to be under as strong an adaptive evolutionary pressure as those of Srz.


Pssm-ID: 402097  Cd Length: 318  Bit Score: 46.43  E-value: 2.75e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927  127 VMALFSLLGNLLTIWNIykTRISRRNSrhtwsAIYSLMFHLSIADvLVTWFCIIGEAA----------WCYTVQWLANEL 196
Cdd:pfam10324   5 ILSFIGFIINIFHLIIL--TRKSMRTS-----SINIIMIGIAICD-IITMLLTIYNFIpefiisyensECIPPDSYLKVL 76
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 442631927  197 TCKLVKLFQMFSLYLSTYVLVLIGVDRWIAVKYPM----KSLNMAKRCHRLLGGTYILSLVLSLPQFF 260
Cdd:pfam10324  77 LDWILESLQDYSRRCSTWLGVFMALIRTLVVKNPMsnkiQKLSKPKFGLIIIIIVFILSLPISIFYYF 144
7tmA_alpha-2D_AR cd15324
alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
120-416 3.29e-05

alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320447 [Multi-domain]  Cd Length: 256  Bit Score: 46.02  E-value: 3.29e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 120 LKVYVLAVMALFSLLGNLLTIWNIYKTRISRRNSRhtwsaiySLMFHLSIADVLVTWFCIIGEAAWCYTVQWLANELTCK 199
Cdd:cd15324    2 LIVLVVVVIILVTIVGNVLVVVAVFTSRALRAPQN-------LFLVSLASADILVATLVIPFSLANEVMGYWYFGSTWCA 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 200 LVKLFQMFSLYLSTYVLVLIGVDRWI----AVKYPMKslNMAKRCHRLLGGTYILSLVLSLPQFFIFHvargpfvEEFYQ 275
Cdd:cd15324   75 FYLALDVLFCTSSIVHLCAISLDRYWsvtkAVSYNLK--RTPKRIKRMIAVVWVISAVISFPPLLMTK-------HDEWE 145
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 276 CVTHgfytadwQEQMYATFTLVFTFLLPLCILFGTYMSTFRTISSSEKMFQgsklanystaklptqtnrqrlihkakmks 355
Cdd:cd15324  146 CLLN-------DETWYILSSCTVSFFAPGLIMILVYCKIYRVAKMREKRFT----------------------------- 189
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 442631927 356 lRISVVIIIAFLICWTPYYVMMIMFMFLNPDKRLGDDLQDAIFFFGMSNSLVNPLIYGAFH 416
Cdd:cd15324  190 -FVLAVVMGVFVLCWFPFFFTYSLHAVCRKRCGIPDALFNLFFWIGYCNSSVNPIIYTIFN 249
7tmA_P2Y8 cd15368
purinergic receptor P2Y8, member of the class A family of seven-transmembrane G ...
122-381 4.21e-05

purinergic receptor P2Y8, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320490 [Multi-domain]  Cd Length: 281  Bit Score: 45.91  E-value: 4.21e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 122 VYVLavMALFSLLGNLLTIWniyktRISRRNSRHTWSAIYslMFHLSIADVLVTWFCIIGEAAWCYTVQWLANELTCKLV 201
Cdd:cd15368    6 VYSL--VALISIPGNLFSLW-----LLCFHTKPKTPSIIF--MINLSLTDLMLACFLPFQIVYHIQRNHWIFGKPLCNVV 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 202 KLFQMFSLYLSTYVLVLIGVDRWIAVKYPMKSlnMAKRCHRLLGGTYILSLVLSLPQFFIFHVARGPFVEEFYQCVThGF 281
Cdd:cd15368   77 TVLFYANMYSSILTMTCISIERYLGVVYPMRS--MRWRKKRYAVAACIGMWLLVLTALSPLERTDLTYYVKELNITT-CF 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 282 YTADWQ----EQMYATFTL---VFTFLLPLCILFGTYMSTFRTISSSEKMFQgsklanystaklptqtnrqrliHKAKMK 354
Cdd:cd15368  154 DVLKWTmlpnIAAWAAFLFtlfILLFLIPFIITVYCYVLIILKLVQTSERYG----------------------REQKRR 211
                        250       260
                 ....*....|....*....|....*..
gi 442631927 355 SLRISVVIIIAFLICWTPYYVMMIMFM 381
Cdd:cd15368  212 AIYLALIVLLVFITCFAPNNFILLAHM 238
7tmA_CCR8 cd15187
CC chemokine receptor type 8, member of the class A family of seven-transmembrane G ...
127-379 5.48e-05

CC chemokine receptor type 8, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR8, the receptor for the CC chemokines CCL1 and CC16, is highly expressed on allergen-specific T-helper type 2 cells, and is implicated in the pathogenesis of human asthma. CCL1- and CCR8-expressing CD4+ effector T lymphocytes are shown to have a critical role in lung mucosal inflammatory responses. CCR8 is also a functional receptor for CCL16, a liver-expressed CC chemokine that involved in attracting lymphocytes, dendritic cells, and monocytes. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320315 [Multi-domain]  Cd Length: 276  Bit Score: 45.56  E-value: 5.48e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 127 VMALFSLLGNLLTIWNIyktrISRRNSRhTWSAIYSLmfHLSIADVLVTwFCIIGEAAWCYTvQWLANELTCKLVKLFQM 206
Cdd:cd15187    9 LLFVFGLLGNSLVIWVL----VACKKLR-SMTDVYLL--NLAASDLLFV-FSLPFQAYYLLD-QWVFGNAMCKIVSGAYY 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 207 FSLYLSTYVLVLIGVDRWIAVKYPMKSLNMAKRCHrllgGTyILSLVL-------SLPQFFIFHVARgpfVEEFYQCVTH 279
Cdd:cd15187   80 IGFYSSMFFITLMSIDRYLAIVHAVYALKVRTASH----GT-ILSLALwlvailaSVPLLVFYQVAS---EDGRLQCIPF 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 280 gFYTADWQEQMYATFTL-VFTFLLPLCILFGTYMSTFRtisssekmfqgsklanystaklptqtNRQRLIHKAKMKSLRI 358
Cdd:cd15187  152 -YPGQGNSWKVFTNFEVnILGLLIPFSILIFCYHNILR--------------------------NLRRCHNQNKTKAIKL 204
                        250       260
                 ....*....|....*....|.
gi 442631927 359 SVVIIIAFLICWTPYYVMMIM 379
Cdd:cd15187  205 VFIVVIVFFLFWTPFNVVLFL 225
7tmA_GPER1 cd14989
G protein-coupled estrogen receptor 1, member of the class A family of seven-transmembrane G ...
198-412 5.63e-05

G protein-coupled estrogen receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled estrogen receptor 1 (GPER1), also known as the G-protein coupled receptor 30 (GPR30), is a high affinity receptor for estrogen. This receptor is a member of the class A of seven-transmembrane GPCRs. Estrogen binding results in intracellular calcium mobilization and synthesis of phosphatidylinositol (3,4,5)-trisphosphate in the nucleus. GPR30 plays an important role in development of tamoxifen resistance in breast cancer cells. The distribution of GPR30 is well established in the rodent, with high expression observed in the hypothalamus, pituitary gland, adrenal medulla, kidney medulla and developing follicles of the ovary. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320120 [Multi-domain]  Cd Length: 276  Bit Score: 45.20  E-value: 5.63e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 198 CKLVKLFQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLNMAKRCHRLL--GGTYILSLVLSLPQFFIFHVArgpFVEEFYQ 275
Cdd:cd14989   71 CTFMSLFLQINMYSSIFFLTWMSFDRYIALAKVMKSSPLRTMQHARLscGLIWMASISATLLPFTAVQAQ---HTGEVHF 147
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 276 CVthgfytADWQEQMYATFTLvfTFLLPLCILFGTYMSTFRTIsssekmfqgsklanystaklpTQTNRQRLIHKAKMKS 355
Cdd:cd14989  148 CF------ADVREIQWLEVTL--GFIIPFSIIGLCYSLIVRVL---------------------VRAQKHRRLRPRRQKA 198
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 442631927 356 LRISVVIIIAFLICWTPYYVmMIMFMFLNPDKRLGDDLQDA-----------IFFFGMSNSLVNPLIY 412
Cdd:cd14989  199 LRMILVVVLVFFICWLPENV-FISIQLLQGTQEPSESYDESfrhnhpltghiVNLAAFSNSCLNPLIY 265
7tmA_NMU-R2 cd15357
neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G ...
124-415 1.83e-04

neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320479 [Multi-domain]  Cd Length: 293  Bit Score: 44.08  E-value: 1.83e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 124 VLAVMALFSLLGNLLTIWNIYKTRISRRNSRHtwsaiysLMFHLSIADVLVTWFCIIGEAAWCYT-VQWLANELTCKL-V 201
Cdd:cd15357    6 VYAVIFVVGVIGNLLVCLVILKHQNMKTPTNY-------YLFSLAVSDLLVLLFGMPLEVYEMWSnYPFLFGPVGCYFkT 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 202 KLFQMFSlYLSTYVLVLIGVDRWIAVKYPM--KSLNMAKRCHRLLGGTYILSLVLSLPQFFIF-----HVARGPFVEEFY 274
Cdd:cd15357   79 ALFETVC-FASILSVTTVSVERYVAILHPFraKLNSTRERALKIIVVLWVLSVLFSIPNTSIHgiklqYFPNGTLIPDSA 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 275 QC-VTHGFYTADWQEQMyatfTLVFTFLLPLCILFGTYMstfrtisssekmFQGSKL-ANYSTAKLPTQTNRQRLIHKAK 352
Cdd:cd15357  158 TCtVVKPLWIYNLIIQI----TSLLFYVLPMGVISVLYY------------LMGLKLrGDKSLEADEMNVNIQRPSRKSV 221
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 442631927 353 MKSLrisVVIIIAFLICWTPYYVMMIMFMF-LNPDKRLGDDLQ-----DAIFFFgmSNSLVNPLIYGAF 415
Cdd:cd15357  222 TKML---FVLVLVFAICWAPFHVDRLFFSFvVEWTEPLANVFNlihvvSGVFFY--LSSAVNPIIYNLL 285
7tmA_NTSR cd15130
neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
128-414 1.92e-04

neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320258 [Multi-domain]  Cd Length: 281  Bit Score: 43.78  E-value: 1.92e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 128 MALFSL--LGNLLTIWNIYKtrisRRNSRHTWSAIYSLMFHLSIADVLVTWFCIIGEA---AWCYTvQWLANELTCKLVK 202
Cdd:cd15130    8 LALFVVgtVGNSVTLFTLAR----KKSLQSLQSTVRYHLGSLALSDLLILLLAMPVELynfIWVHH-PWAFGDAGCRGYY 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 203 LFQMFSLYLSTYVLVLIGVDRWIAVKYPMK--SLNMAKRCHRLLGGTYILSLVLSLPQFFIF----HVARGPfvEEFYQC 276
Cdd:cd15130   83 FLRDACTYATALNVASLSVERYLAICHPFKakTLMSRSRTKKFISAIWLASALLAIPMLFTMglqnESDDGT--HPGGLV 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 277 VTHGFYTAdwQEQMYATFTLVFTFLLPLCILfgtymSTFRTISSSekmfqgsklanystaklptqtnrqRLIhKAKMKSL 356
Cdd:cd15130  161 CTPIVDTA--TLKVVIQVNTFMSFLFPMLVT-----SILNTVIAN------------------------KLV-QALRRGV 208
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 442631927 357 RISVVIIIAFLICWTPYYVMMIMFMFLnPDKRLGDDLQDAIFFFGM-------SNSLVNPLIYGA 414
Cdd:cd15130  209 LVLRAVVIAFVVCWLPYHVRRLMFCYI-SDEQWTTFLFDFYHYFYMltnalfyVSSAINPILYNL 272
7tmA_LPAR5 cd15154
lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G ...
155-412 2.05e-04

lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 5 (LPAR5) is a G protein-coupled receptor that binds the bioactive lipid lysophosphatidic acid (LPA) and is involved in maintenance of human hair growth. Phylogenetic analysis of the class A GPCRs shows that LAPR5 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(q) and G(12/13) proteins.


Pssm-ID: 320282 [Multi-domain]  Cd Length: 285  Bit Score: 43.60  E-value: 2.05e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 155 HTWSAIYslMFHLSIADVLVTwFCIIGEAAWCYTVQWLANELTCKLV-KLFQMfSLYLSTYVLVLIGVDRWIAVKYPMKS 233
Cdd:cd15154   32 HSVVSIY--MCNLALSDLLFT-LSLPLRIYYYANHYWPFGNFLCQFSgSIFQM-NMYGSCLFLMCINVDRYLAIVHPLRF 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 234 LNMAK-RCHRLLG-GTYILSLVLSLPQFFIFHVARGPFV-EEFYQCVtHGFYTADWQEQM-YATFTLVFTFLLPLCILFG 309
Cdd:cd15154  108 RHLRRpKVARLLClAVWALILGGSVPAAIVHSSSDCLLHgEKVYRCF-ESFSDNDWKGLLpLVVLAEILGFLLPLAAVLY 186
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 310 TYMSTFRTISSSEKmfqgsklanystaklpTQTNRQRlihkakmKSLRISVVIIIAFLICWTPYYVMMIMFMFLNP---- 385
Cdd:cd15154  187 CSCRIFVELCRTQE----------------PQQGRRR-------KTVRLLLVNLVIFLICFVPYNTTLAVYGLLRAnlve 243
                        250       260       270
                 ....*....|....*....|....*....|.
gi 442631927 386 -DKRLGDDLQDAI---FFFGMSNSLVNPLIY 412
Cdd:cd15154  244 dTWNIKDTLRKVLsvtVLLASTNCALDPLVY 274
7tmA_LPAR6_P2Y5 cd15156
lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G ...
124-412 2.41e-04

lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 6 (LPAR6), also known as P2Y5, is a G(i), G(12/13) G protein-coupled receptor that is activated by the bioactive lipid lysophosphatidic acid (LPA), which is released by activated platelets and constitutively present in serum. LPAR6 plays an important role in maintenance of human hair growth. Thus, mutations in the receptor are responsible for both autosomal recessive wooly hair and hypotrichosis. Phylogenetic analysis of the class A GPCRs shows that LAPR6 (P2Y5) is classified into the cluster consisting of receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production.


Pssm-ID: 320284 [Multi-domain]  Cd Length: 285  Bit Score: 43.30  E-value: 2.41e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 124 VLAVMALFSLLGNLLTIWnIYKTRISRRNSRHTWsaiyslMFHLSIADVLVTwFCIIGEAAWCYTVQWLANELTCKLVKL 203
Cdd:cd15156    6 VFSMVFVLGLIANCVAIY-IFMCTLKVRNETTTY------MINLAISDLLFV-FTLPFRIFYFVQRNWPFGDLLCKISVT 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 204 FQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLNM-AKRCHRLL-GGTYILSLVLSLPQFFIFHVARgpFVEEFYQCVTHGF 281
Cdd:cd15156   78 LFYTNMYGSILFLTCISVDRFLAIVYPFRSKTLrTKRNAKIVcAAVWLTVLAGSLPASFFQSTNN--QLNNNSETCFENF 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 282 YTADWQEQM--YATFTLVFTFLLPLCIlfgtymstfrTISSSEKMFQgsklanysTAKLPTQTNRQRLihkAKMKSLRIS 359
Cdd:cd15156  156 SSKTWKTYLskIVIFIEIVGFFIPLIL----------NVTCSTMVLK--------TLRRPNTLSRSKL---NKKKVLKMI 214
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 360 VVIIIAFLICWTPYYVMMIMFMFLNPDKRLGDDLQDAI-------FFFGMSNSLVNPLIY 412
Cdd:cd15156  215 FVHLFIFCFCFIPYNVNLVLYSLVRTQTFKNCSVVAAVrtmypitLCIAVSNCCFDPIVY 274
7tmA_TRH-R cd14995
thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G ...
122-414 2.83e-04

thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; TRH-R is a member of the class A rhodopsin-like G protein-coupled receptors, which binds the tripeptide thyrotropin releasing hormone. The TRH-R activates phosphoinositide metabolism through a pertussis-toxin-insensitive G-protein, the G(q)/G(11) class. TRH stimulates the synthesis and release of thyroid-stimulating hormone in the anterior pituitary. TRH is produced in many other tissues, especially within the nervous system, where it appears to act as a neurotransmitter/neuromodulator. It also stimulates the synthesis and release of prolactin. In the CNS, TRH stimulates a number of behavioral and pharmacological actions, including increased turnover of catecholamines in the nucleus accumbens. There are two thyrotropin-releasing hormone receptors in some mammals, thyrotropin-releasing hormone receptor 1 (TRH1) which has been found in a number of species including rat, mouse, and human and thyrotropin-releasing hormone receptor 2 (TRH2) which has, only been found in rodents. These TRH receptors are found in high levels in the anterior pituitary, and are also found in the retina and in certain areas of the brain.


Pssm-ID: 320126 [Multi-domain]  Cd Length: 269  Bit Score: 43.14  E-value: 2.83e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 122 VYVLAVMALFSLLGNLLTIWNIYKTRisrrnSRHTWSAIYslMFHLSIADVLVTWFCII-GEAAWCYTV-QWLANELTCK 199
Cdd:cd14995    4 TFLVLLICGVGIVGNIMVVLVVLRTR-----HMRTPTNCY--LVSLAVADLMVLVAAGLpNEIESLLGPdSWIYGYAGCL 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 200 LVKLFQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLNMA--KRCHRLLGGTYILSLVLSLPQFFIFHVArgPFVEEFYQCV 277
Cdd:cd14995   77 LITYLQYLGINASSLSITAFTIERYIAICHPMKAQFICtvSRAKKIICFVWIFTSLYCSPWLFLLDLS--IKHYGDDIVV 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 278 THGFYTADWQEQMYATFTLVFTFLLPL---CILFGTYMstfRTISSSEKMFqgsklanystaklptqtnrqrlihkAKMk 354
Cdd:cd14995  155 RCGYKVSRHYYLPIYLADFVLFYVIPLllaIVLYGLIG---RILFSSRKQV-------------------------TKM- 205
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 442631927 355 slriSVVIIIAFLICWTPYYVMMIMFMFLNPdkrlgdDLQDAIFFFGMS-----NSLVNPLIYGA 414
Cdd:cd14995  206 ----LAVVVVLFALLWMPYRTLVVYNSFASP------PYLDLWFLLFCRtciylNSAINPILYNL 260
7tmA_5-HT2B cd15306
serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G ...
161-416 3.08e-04

serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341347 [Multi-domain]  Cd Length: 277  Bit Score: 43.28  E-value: 3.08e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 161 YSLMfHLSIADVLVTWFCI-IGEAAWCYTVQWLANELTCKLVKLFQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLNMAKR 239
Cdd:cd15306   37 YFLM-SLAVADLLVGLFVMpIALLTILFEAMWPLPLVLCPIWLFLDVLFSTASIMHLCAISLDRYIAIKKPIQASQYNSR 115
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 240 CHRLLGGT--YILSLVLSLPqFFIFHVARGPFVEEFYQCVthgFYTADWQEqmYATFTLVFTFLLPLCILFGTYMSTFRT 317
Cdd:cd15306  116 ATAFIKITvvWLISIGIAIP-VPIKGIETDVDNPNNITCV---LTKERFGD--FILFGSLAAFFTPLAIMIVTYFLTIHA 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 318 ISSSekmfqgsklanystaklpTQTNRQRlihkakmkSLRISVVIIIAFLICWTPYYVMMIMFMFLNP-DKRLGDDLQDA 396
Cdd:cd15306  190 LRKQ------------------TITNEQR--------ASKVLGIVFFLFLLMWCPFFITNITSVLCDScNQTTLQMLMEI 243
                        250       260
                 ....*....|....*....|
gi 442631927 397 IFFFGMSNSLVNPLIYGAFH 416
Cdd:cd15306  244 FVWIGYVSSGVNPLVYTLFN 263
7tmA_PAR1 cd15369
protease-activated receptor 1, member of the class A family of seven-transmembrane G ...
158-412 3.17e-04

protease-activated receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320491  Cd Length: 281  Bit Score: 43.22  E-value: 3.17e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 158 SAIYslMFHLSIADVLVTWFCIIGEAAWCYTVQWLANELTCKLVKLFQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLN-- 235
Cdd:cd15369   35 AVIY--MLNLACADLLFVLLLPFKIAYHFSGNDWLFGEAMCRVVTAAFYCNMYCSILLMTCISVDRFLAVVYPMQSLSwr 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 236 MAKRCHRLLGGTYILSLVLSLPQFFIFHVARgpfVEEFYQCVTHGFYTADWQEQMYATFTLVFT---FLLPLCILFGTYM 312
Cdd:cd15369  113 TLRRASFTCAAIWLLSIAGVVPLLLSEQTIQ---IPDLGITTCHDVLNEQLLMGYYVYYFSIFSclfFFVPLIITTVCYV 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 313 STFRTISSSEKMFQGSKlanystaklptqtnrqrlihkaKMKSLRISVVIIIAFLICWTPYYVMMIMFMFLNPDKRLGDD 392
Cdd:cd15369  190 SIIRCLSSSSDVANSSK----------------------KTRALFMAVAVFCVFVICFGPTNVLLLAHYVRFAYTSTNDA 247
                        250       260
                 ....*....|....*....|...
gi 442631927 393 LQDAIFFF---GMSNSLVNPLIY 412
Cdd:cd15369  248 SYFAYLLCvcvGSISCCLDPLIY 270
PHA02834 PHA02834
chemokine receptor-like protein; Provisional
190-379 3.42e-04

chemokine receptor-like protein; Provisional


Pssm-ID: 165177  Cd Length: 323  Bit Score: 43.35  E-value: 3.42e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 190 QWLANELTCKLVKLFQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLNMAKRCHRLLG-GTYILSLVLSLPQFFIFHVARGP 268
Cdd:PHA02834  90 EWIFGEFMCKLVLGVYFVGFFSNMFFVTLISIDRYILVVNATKIKNKSISLSVLLSvAAWVCSVILSMPAMVLYYVDNTD 169
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 269 FVEefyQCVTHGfYTADWQEQMYATFTL-VFTFLLPLCILFGTYMSTFRTISSSEkmfqgsklanystaklptqtnrqrl 347
Cdd:PHA02834 170 NLK---QCIFND-YHENFSWSAFFNFEInIFGIVIPLIILIYCYSKILYTLKNCK------------------------- 220
                        170       180       190
                 ....*....|....*....|....*....|..
gi 442631927 348 iHKAKMKSLRISVVIIIAFLICWTPYYVMMIM 379
Cdd:PHA02834 221 -NKNKTRSIKIILTVVTFTVVFWVPFNIVLFI 251
7tmA_GPR61_GPR62-like cd15220
G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G ...
120-413 3.64e-04

G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the orphan receptors GPR61 and GPR62, which are both constitutively active and predominantly expressed in the brain. While GPR61 couples to G(s) subtype of G proteins, the signaling pathway and function of GPR 62 are unknown. GPR61-deficient mice displayed significant hyperphagia and heavier body weight compared to wild-type mice, suggesting that GPR61 is involved in the regulation of food intake and body weight. GPR61 transcript expression was found in the caudate, putamen, and thalamus of human brain, whereas GPR62 transcript expression was found in the basal forebrain, frontal cortex, caudate, putamen, thalamus, and hippocampus. Both receptors share the highest sequence homology with each other and comprise a conserved subgroup within the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. Members of this subgroup contain [A/E]RY motif, a variant of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the class A GPCRs and important for efficient G protein-coupled signal transduction.


Pssm-ID: 410633 [Multi-domain]  Cd Length: 264  Bit Score: 42.82  E-value: 3.64e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 120 LKVYVLAVMALFSLLGNLLTIWNIYKTRISRRnsrhtwsaiYSLMFHLSIADVLVTWFC----IIGEAAWCYTVqwLANE 195
Cdd:cd15220    1 VGLFCMVLLDLTALVGNTAVMVVIAKTPHLRK---------FAFVCHLCVVDLLAALLLmplgILSSSPFFLGV--VFGE 69
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 196 LTCKLVKLFQMFSLYLSTYVLVLIGVDRWIAVKYPMK-SLNMAKRCHRL-LGGTYILSLVLSLPQFFIFHVARGPFVEEF 273
Cdd:cd15220   70 AECRVYIFLSVCLVSASILTISAISVERYYYIVHPMRyEVKMTIGLVAAvLVGVWVKALLLGLLPVLGWPSYGGPAPIAA 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 274 YQCVTHGFYTAdwQEQMYATFTLVFTFLLPLCILFGTYMSTFrtissseKMFQGSKLAnystaklptqtnrqrlihkakm 353
Cdd:cd15220  150 RHCSLHWSHSG--HRGVFVVLFALVCFLLPLLLILVVYCGVF-------KVFGGGKAA---------------------- 198
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 354 kslRISVVIIIAFLICWTPYYVMMIMFMFLNPDKRLGdDLQDAIFFFGMSNSLVNPLIYG 413
Cdd:cd15220  199 ---LTLAAIVGQFLCCWLPYFAFHLYSALAASPVSGG-EAEEVVTWLAYSCFAVNPFFYG 254
7tmA_HCAR-like cd14991
hydroxycarboxylic acid receptors and related proteins, member of the class A family of ...
124-413 3.94e-04

hydroxycarboxylic acid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the hydroxycarboxylic acid receptors (HCARs) as well as their closely related receptors, GPR31 and oxoeicosanoid receptor 1 (OXER1). HCARs are members of the class A family of G-protein coupled receptors (GPCRs). HCAR subfamily contain three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2, orGPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. All three HCA receptors are expressed in adipocytes, and are coupled to G(i)-proteins mediating anti-lipolytic effects in fat cells. OXER1 is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid, whereas GPR31 is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12-S-HETE).


Pssm-ID: 320122 [Multi-domain]  Cd Length: 280  Bit Score: 42.82  E-value: 3.94e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 124 VLAVMALFSLLGNLLTIWNIYKtrisrrNSRhTWSAIYSLMFHLSIADVLV-------TWFCIIGEAawcytvqWLANEL 196
Cdd:cd14991    6 LLILEFVLGLPGNVVALWIFCF------HSR-TWKANTVYLFNLVLADFLLliclpfrIDYYLRGEH-------WIFGEA 71
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 197 TCKLVkLFqMFSLYLSTYV--LVLIGVDRWIAVKYPMKSLNMA--KRCHRLLGGTYILSLVLSLPQFFIFHVAR---GPF 269
Cdd:cd14991   72 WCRVN-LF-MLSVNRSASIafLTAVALDRYFKVVHPHHRVNRMsvKAAAGVAGLLWALVLLLTLPLLLSTLLTVnsnKSS 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 270 VEEFYQcVTHGFYTADWQEQMYatftlVFTFLLPLCILFGTYMSTFRTISssekmfqgsklanystaklptqtNRQRLIH 349
Cdd:cd14991  150 CHSFSS-YTKPSLSIRWHNALF-----LLEFFLPLGLIVFCSVRIACNLR-----------------------IRQSLGK 200
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 350 KAKMK-SLRISVVIIIAFLICWTPYYVMMIMFMFLNPDKRLGDD-----LQDAIFFFGMSNSLVNPLIYG 413
Cdd:cd14991  201 QARVQrAIRLVFLVVIVFVLCFLPSIIAGLLALVFKNLGSCRCLnsvaqLFHISLAFTYLNSALDPVIYC 270
7tmA_Adenosine_R_A1 cd15071
adenosine receptor subtype A1, member of the class A family of seven-transmembrane G ...
126-412 4.25e-04

adenosine receptor subtype A1, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine A1 receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand. The A1 receptor has primarily inhibitory function on the tissues in which it is located. The A1 receptor slows metabolic activity in the brain and has a strong anti-adrenergic effects in the heart. Thus, it antagonizes beta1-adrenergic receptor-induced stimulation and thereby reduces cardiac contractility. The A1 receptor preferentially couples to G proteins of the G(i/o) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels.


Pssm-ID: 341323 [Multi-domain]  Cd Length: 290  Bit Score: 42.91  E-value: 4.25e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 126 AVMALFSLLGNLLTIWNIYKTRISRrnsrhtwSAIYSLMFHLSIADVLVTWFCI-------IGEAAWCYTVQWLAneltC 198
Cdd:cd15071    8 VLIALVSVPGNVLVIWAVKVNQALR-------DATFCFIVSLAVADVAVGALVIplaiiinIGPQTEFYSCLMVA----C 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 199 KLVKLFQMfslylSTYVLVLIGVDRWIAVKYPM--KSLNMAKRCHRLLGGTYILSLVLSLPQFFIFH------VARGPFV 270
Cdd:cd15071   77 PVLILTQS-----SILALLAIAVDRYLRVKIPTryKSVVTPRRAAVAIAGCWILSFLVGLTPMFGWNnlnaveRAWAANS 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 271 EEFYQCVTHGFYTADWQEQMyATFTLVFTFLLPLCILFGTYMSTFRTISSsekmfQGSKlanystaKLPTQTNRQRLIHK 350
Cdd:cd15071  152 SMGELVIKCQFETVISMEYM-VYFNFFVWVLPPLLLMLLIYLEVFYLIRK-----QLNK-------KVSSSSSDPQKYYG 218
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 442631927 351 AKMKSLRISVVIIIAFLICWTPYYVMMIMFMFLNPDKRLGDDLQDAIfFFGMSNSLVNPLIY 412
Cdd:cd15071  219 KELKIAKSLALILFLFALSWLPLHILNCITLFCPSCKKPMILTYIAI-FLTHGNSAMNPIVY 279
7tmA_Mel1A cd15402
melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
124-413 5.82e-04

melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320524 [Multi-domain]  Cd Length: 279  Bit Score: 42.20  E-value: 5.82e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 124 VLAVMALFSLLGNLLTIWNIYKTRiSRRNSRHTWsaiyslMFHLSIADVLVTWFCIIGEAAWCYTVQWLANELTCKLVKL 203
Cdd:cd15402    6 ILIFTIVVDILGNLLVILSVYRNK-KLRNAGNIF------VVSLAVADLVVAIYPYPLVLTSIFHNGWNLGYLHCQISGF 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 204 FQMFSLYLSTYVLVLIGVDRWI----AVKYPMKSLNMAKRCHRLLggTYILSLVLSLPQFFIFHVARGPFVeefYQCVth 279
Cdd:cd15402   79 LMGLSVIGSIFNITGIAINRYCyichSLKYDKLYSDKNSLCYVLL--IWVLTVAAIVPNLFVGSLQYDPRI---YSCT-- 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 280 gfyTADWQEQMYATFTLVFTFLLPLCILFGTYMSTFRTISSSEKmfqgsKLANYSTAKLPTQTNRqrlihkakmkSLRIS 359
Cdd:cd15402  152 ---FAQSVSSAYTIAVVFFHFILPIIIVTFCYLRIWILVIQVRR-----RVKPDNKPKLKPHDFR----------NFVTM 213
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 442631927 360 VVIIIAFLICWTPYYVMMIMfMFLNPDK---RLGDDLQDAIFFFGMSNSLVNPLIYG 413
Cdd:cd15402  214 FVVFVLFAVCWAPLNFIGLA-VAVDPETivpRIPEWLFVASYYMAYFNSCLNAIIYG 269
7tmA_CCR10 cd15177
CC chemokine receptor type 10, member of the class A family of seven-transmembrane G ...
124-379 6.45e-04

CC chemokine receptor type 10, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR10 is a homeostatic receptor specific for two C-C motif chemokines, CCL27 and CCL28. Activation of CCR10 by its two ligands mediates diverse activities, ranging from leukocyte trafficking to skin cancer. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341332 [Multi-domain]  Cd Length: 280  Bit Score: 42.07  E-value: 6.45e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 124 VLAVMALFSLLGNLLTIwniyKTRISRRNSRhtwSAIYSLMFHLSIADVLvtwFCIIGEAAWCYTVQ-WLANELTCKLVK 202
Cdd:cd15177    6 VYLVVFVLGLVGNGLVL----ATHTRYRRLR---SMTDVYLLNLALADLL---LLLTLPFAAAETLQgWIFGNAMCKLIQ 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 203 LFQMFSLYLSTYVLVLIGVDRWIAVKypmkslnMAKRCHRLLGGT-----------YILSLVLSLPQFFIFHVARGpfvE 271
Cdd:cd15177   76 GLYAINFYSGFLFLTCISVDRYVVIV-------RATSAHRLRPKTlfysvltslivWLLSILFALPQLIYSRVENR---S 145
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 272 EFYQC-VTHGFYTADWQEQMYATFTLVFTFLLPLCILFGTYMSTFRTIsssekmfqgsklanystakLPTQTNRQRlihk 350
Cdd:cd15177  146 ELSSCrMIFPEVVSRTVKGATALTQVVLGFAIPLIVMAVCYAAIGRTL-------------------LAARGWERH---- 202
                        250       260
                 ....*....|....*....|....*....
gi 442631927 351 akmKSLRISVVIIIAFLICWTPYYVMMIM 379
Cdd:cd15177  203 ---RALRVIAALVVAFVLFQLPYSVVLLL 228
7tmA_5-HT2C cd15305
serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...
127-416 6.83e-04

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341346 [Multi-domain]  Cd Length: 275  Bit Score: 42.20  E-value: 6.83e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 127 VMALFSLLGNLLTIwniykTRISRRNSRHtwSAIYSLMFHLSIADVLVTWFCI-IGEAAWCYTVQW-LANELTCKLVKLF 204
Cdd:cd15305    9 IIIILTIGGNILVI-----MAVSLEKKLQ--NATNFFLMSLAVADMLVGILVMpVSLIAILYDYAWpLPRYLCPIWISLD 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 205 QMFSLyLSTYVLVLIGVDRWIAVKYPMKSLNMAKRCHRLL--GGTYILSLVLSLPqFFIFHVARGPFVEEFYQCVTHgfy 282
Cdd:cd15305   82 VLFST-ASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAMMkiAAVWTISIGISMP-IPVIGLQDDEKVFVNGTCVLN--- 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 283 tadwqEQMYATFTLVFTFLLPLCILFGTYMSTFRTIsssekmfqgsklanystaklptqtNRQRLIHKAKMKSLRISVVI 362
Cdd:cd15305  157 -----DENFVLIGSFVAFFIPLIIMVITYCLTIQVL------------------------QRQQAINNERRASKVLGIVF 207
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 442631927 363 IIaFLICWTPYYVMMIMFMFLNP--DKRLGDDLQDAIFFFGMSNSLVNPLIYGAFH 416
Cdd:cd15305  208 FL-FLIMWCPFFITNILSVLCKEacDQKLMEELLNVFVWVGYVSSGINPLVYTLFN 262
7tmA_GPR33 cd15120
orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled ...
157-412 6.95e-04

orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor GPR33, an orphan member of the chemokine-like receptor family, was originally identified as a pseudogene in humans as well as in several apes and rodent species. Although the intact GPR33 allele is still present in a small fraction of the human population, the human GPR33 contains a premature stop codon. The amino acid sequence of GPR33 shares a high degree of sequence identity with the members of the chemokine and chemoattractant receptors that control leukocyte chemotaxis. The human GPR33 is expressed in spleen, lung, heart, kidney, pancreas, thymus, gonads, and leukocytes.


Pssm-ID: 320248 [Multi-domain]  Cd Length: 282  Bit Score: 42.08  E-value: 6.95e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 157 WSAIYSLMFHLSIADVLVTWFCIIGEAAWCYTVQWLANELTCKLVKLFQMFSLYLSTYVLVLIGVDRWIAVKYPMKSlnm 236
Cdd:cd15120   31 RTVNTLWFLHLILSNLIFTLILPFMAVHVLMDNHWAFGTVLCKVLNSTLSVGMFTSVFLLTAISLDRYLLTLHPVWS--- 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 237 akRCHR-------LLGGTYILSLVLSLPqFFIFHVAR----GPFVEEFYQCVTHGFYTADWQE---QMYA---TFTLVFT 299
Cdd:cd15120  108 --RQHRtnrwasaIVLGVWISAILLSIP-YLAFRETRldekGKTICQNNYALSTNWESAEVQAsrqWIHVamfVFRFLLG 184
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 300 FLLPLCILFGTYmstfrtisssEKMfqGSKLANYSTAKlptqtnrqrlihkaKMKSLRISVVIIIAFLICWTPYYVMMIM 379
Cdd:cd15120  185 FLLPFLIITFCY----------VRM--ALKMKERGLAR--------------SSKPFKVMFTAVVSFFVCWLPYHLHSGL 238
                        250       260       270
                 ....*....|....*....|....*....|....
gi 442631927 380 FMFLNPDKRLGD-DLQDAIFFFGMsNSLVNPLIY 412
Cdd:cd15120  239 VLTRGRPPSLTDiTLLLTVGTTCF-NTCFTPVLY 271
7tmA_GPR4 cd15366
proton-sensing G protein-coupled receptor 4, member of the class A family of ...
136-378 8.92e-04

proton-sensing G protein-coupled receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein-coupled receptor 4 (GPR4) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 receptor (TDAG8, GPR65), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. GPR4 overexpression in melanoma cells was shown to reduce cell migration, membrane ruffling, and cell spreading under acidic pH conditions. Activation of GPR4 via extracellular acidosis is coupled to the G(s), G(q), and G(12/13) pathways.


Pssm-ID: 320488 [Multi-domain]  Cd Length: 280  Bit Score: 41.70  E-value: 8.92e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 136 NLLTIWNIYkTRISRRNSRhtwsAIYslMFHLSIADVLVtwfcIIGEAAWC-YTVQ---WLANELTCKLVKLFQMFSLYL 211
Cdd:cd15366   18 NCLALWAAY-LQVRQRNEL----GVY--LLNLSVSDLLY----IATLPLWIdYFLHrdnWIHGPESCKLFGFIFYTNIYI 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 212 STYVLVLIGVDRWIAVKYPMK--SLNMAKRCHRLLGGTYILSLVLSLPQFFIFHVARGPFVEEFyqCVtHGFYTADWQEQ 289
Cdd:cd15366   87 SIAFLCCISVDRYLAVAHPLRfaKVRRVKTAVAVSAVVWAIEIGANSAPLFHDELFRDRYNHTF--CF-EKYPMEDWVAW 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 290 M--YATFTlvfTFLLPLCILFGTYMSTFRTISSSekmfqgsklanystaklpTQTNRQrliHKAKMKSLRISVVIIIafL 367
Cdd:cd15366  164 MnlYRVFV---GFLFPWVLMLFSYRGILRAVRGN------------------VSTEQQ---EKAKIKRLALSLIAIV--L 217
                        250
                 ....*....|.
gi 442631927 368 ICWTPYYVMMI 378
Cdd:cd15366  218 LCFAPYHVLLL 228
7tmA_GHSR cd15131
growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G ...
126-380 9.23e-04

growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Growth hormone secretagogue receptor, GHSR, is also known as GH-releasing peptide receptor (GHRP) or Ghrelin receptor. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin, also called hunger hormone, is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. It also plays a role in the cardiovascular, immune, and reproductive systems. GHSR couples to G-alpha-11 proteins. Both ghrelin and GHSR are expressed in a wide range of cancer tissues. Recent studies suggested that ghrelin may play a role in processes associated with cancer progression, including cell proliferation, metastasis, apoptosis, and angiogenesis.


Pssm-ID: 320259 [Multi-domain]  Cd Length: 291  Bit Score: 41.79  E-value: 9.23e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 126 AVMALFSLLGNLLTIWNIYKTRISRrnsrhTWSAIYslMFHLSIADVLVtWFCIIGEAA--WCYTvQWLANELTCKLVKL 203
Cdd:cd15131    8 VLLFVVGVTGNLMTMLVVSKYRDMR-----TTTNLY--LSSMAFSDLLI-FLCMPLDLYrlWQYR-PWNFGDLLCKLFQF 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 204 FQMFSLYLSTYVLVLIGVDRWIAVKYPMKS--LNMAKRCHRLLGGTYILSLVLSLPQFFIFHVAR--GPFVEEFYQCVTH 279
Cdd:cd15131   79 VSESCTYSTILNITALSVERYFAICFPLRAkvVVTKRRVKLVILVLWAVSFLSAGPIFVLVGVEHenGTNPIDTNECKAT 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 280 GFYTADWQEQMYATFTLVFtFLLPLCILFGTYMSTFRtissseKMFQGSKLANYSTAKLPTQTNRQrlihkakmkSLRIS 359
Cdd:cd15131  159 EYAVRSGLLTIMVWVSSVF-FFLPVFCLTVLYSLIGR------KLWRRRRENIGPNASHRDKNNRQ---------TVKML 222
                        250       260
                 ....*....|....*....|.
gi 442631927 360 VVIIIAFLICWTPYYVMMIMF 380
Cdd:cd15131  223 AVVVFAFVLCWLPFHVGRYLF 243
7tmA_5-HT2A cd15304
serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...
117-416 1.15e-03

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341345 [Multi-domain]  Cd Length: 267  Bit Score: 41.07  E-value: 1.15e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 117 SGLLKVYVLAVmalfSLLGNLLTIwniyktrISRRNSRHTWSAIYSLMFHLSIADVLVTWFCI-IGEAAWCYTVQW-LAN 194
Cdd:cd15304    3 PALLTVIVIIL----TIAGNILVI-------MAVSLEKKLQNATNYFLMSLAIADMLLGFLVMpVSMLTILYGYRWpLPS 71
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 195 ELTCKLVKLFQMFSLyLSTYVLVLIGVDRWIAVKYPMKSLNMAKRCHRLLG--GTYILSLVLSLPqFFIFHVARGPFVEE 272
Cdd:cd15304   72 KLCAVWIYLDVLFST-ASIMHLCAISLDRYIAIRNPIHHSRFNSRTKAFLKiiAVWTISVGISMP-IPVFGLQDDSKVFK 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 273 FYQCVThgfytADWQEQMYATFTlvfTFLLPLCILFGTYMSTFRTISSSekmfqgsklanystaklptQTNRQrlihkak 352
Cdd:cd15304  150 EGSCLL-----ADENFVLIGSFV---AFFIPLTIMVITYFLTIKSLQQS-------------------ISNEQ------- 195
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 442631927 353 mKSLRISVVIIIAFLICWTPYYVMMIMFMFLNP--DKRLGDDLQDAIFFFGMSNSLVNPLIYGAFH 416
Cdd:cd15304  196 -KASKVLGIVFFLFVVMWCPFFITNVMAVICKEscNEVVIGGLLNVFVWIGYLSSAVNPLVYTLFN 260
7tmA_MC5R cd15354
melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G ...
120-412 1.20e-03

melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320476 [Multi-domain]  Cd Length: 270  Bit Score: 41.08  E-value: 1.20e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 120 LKVYVLAVMALFSLLGNLLTIWNIYKtrisrrnSRHTWSAIYSLMFHLSIADVLVTWfciigEAAWCYTVQWLANELTCK 199
Cdd:cd15354    2 IAAEVFLTLGIISLLENILVILAIVK-------NKNLHSPMYFFVCSLAVADMLVSV-----SNAWETITIYLLNNRHLV 69
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 200 LVKLF--QM---------FSLYLSTYVLVLIGVDRWIAVKYPMKSLNM--AKRCHRLLGGTYILslvlslpqffifhvar 266
Cdd:cd15354   70 IEDAFvrHIdnvfdslicISVVASMCSLLAIAVDRYVTIFYALRYHNImtVRRAGIIIACIWTF---------------- 133
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 267 gpfveefyqCVTHGFYTADWQEQMYATFTLVFTFLLPLCILFGTYMSTFRTISSSEKmfqgsklanySTAKLPTQTN-RQ 345
Cdd:cd15354  134 ---------CTGCGIIFILYSESTYVIICLITMFFAMLFLMVSLYIHMFLLARTHVK----------RIAALPGYNSvRQ 194
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 346 RlihkAKMKSLRISVVIIIAFLICWTPYYVMMIMfMFLNPDKRLGDDLQ---DAIFFFGMSNSLVNPLIY 412
Cdd:cd15354  195 R----TSMKGAVTLTILLGIFIVCWAPFFLHLIL-MISCPQNLYCVCFMshfNMYLILIMCNSVIDPLIY 259
7tmA_Mel1B cd15400
melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
124-413 1.75e-03

melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320522 [Multi-domain]  Cd Length: 279  Bit Score: 40.61  E-value: 1.75e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 124 VLAVMALFSLLGNLLTIWNIYKTRiSRRNSRHTWsaiyslMFHLSIADVLVTWFCIIGEAAWCYTVQWLANELTCKLVKL 203
Cdd:cd15400    6 VLIFTTVVDILGNLLVIISVFRNR-KLRNSGNVF------VVSLALADLVVALYPYPLVLVAIFHNGWALGEMHCKVSGF 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 204 FQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLNMAKRCHRLLGGTYI--LSLVLSLPQFFIFHVARGPFVeefYQCVThgf 281
Cdd:cd15400   79 VMGLSVIGSIFNITGIAINRYCYICHSFAYDKLYSRWNTLLYVCLIwaLTVVAIVPNFFVGSLEYDPRI---YSCTF--- 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 282 ytADWQEQMYATFTLVFTFLLPLCILFGTYMSTFRTISSSEKmfqgsklanystaKLPTQTnRQRLiHKAKMKSLRISVV 361
Cdd:cd15400  153 --VQTASSSYTIAVVVIHFIVPITVVSFCYLRIWVLVIQVRR-------------KVKSES-KPRL-KPSDFRNFLTMFV 215
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 442631927 362 IIIAFLICWTPYYVMMIMfMFLNPDK---RLGDDLQDAIFFFGMSNSLVNPLIYG 413
Cdd:cd15400  216 VFVIFAICWAPLNLIGLA-VAINPQEmapKVPEWLFVVSYFMAYFNSCLNAIIYG 269
7tmA_D2_dopamine_R cd15309
D2 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
163-417 1.94e-03

D2 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320435 [Multi-domain]  Cd Length: 254  Bit Score: 40.40  E-value: 1.94e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 163 LMFHLSIADVLVTWFCIIGEAAWCYTVQWLANELTCKLVKLFQMFSLYLSTYVLVLIGVDRWIAVKYPM---KSLNMAKR 239
Cdd:cd15309   38 LIVSLAVADLLVATLVMPWVVYLEVVGEWRFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMlynTRYSSKRR 117
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 240 CHRLLGGTYILSLVLSLPQFFifhvarGPFVEEFYQCVThgfytadwQEQMYATFTLVFTFLLPLCILFGTYMSTFRtis 319
Cdd:cd15309  118 VTVMISVVWVLSFAISCPLLF------GLNNTDQNECII--------ANPAFVVYSSIVSFYVPFIVTLLVYVQIYI--- 180
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 320 ssekmfqgsklanystaklptqtnrqrLIHKAKmKSLRISVVIIIAFLICWTPYYVMMIMFMFLNPDkrLGDDLQDAIFF 399
Cdd:cd15309  181 ---------------------------VLQKEK-KATQMLAIVLGVFIICWLPFFITHILNMHCDCN--IPPALYSAFTW 230
                        250
                 ....*....|....*...
gi 442631927 400 FGMSNSLVNPLIYGAFHL 417
Cdd:cd15309  231 LGYVNSAVNPIIYTTFNI 248
7tmA_GPR31 cd15199
G protein-coupled receptor 31, member of the class A family of seven-transmembrane G ...
133-412 2.03e-03

G protein-coupled receptor 31, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR31, also known as 12-(S)-HETE receptor, is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid. Phylogenetic analysis showed that GPR31 and oxoeicosanoid receptor 1 (OXER1, GPR170) are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). GPR31, like OXER1, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike the OXER1, does not cause increase in the cytosolic calcium level. GPR31 is also shown to activate NFkB. 12-(S)-HETE is a 12-lipoxygenase metabolite of arachidonic acid produced by mammalian platelets and tumor cells. It promotes tumor cells adhesion to endothelial cells and sub-endothelial matrix, which is a critical step for metastasis.


Pssm-ID: 320327 [Multi-domain]  Cd Length: 278  Bit Score: 40.55  E-value: 2.03e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 133 LLGNLLTIWN-IYKTRISRRNsrhtwsAIYslMFHLSIADVLVTwFCIIGEAAWCYTVQ-WLANELTCKLVKLFQMFSLY 210
Cdd:cd15199   15 LPGNAIALWTfIFRLKVWKPY------AVY--LLNLVLADVLLL-ICLPFKAYFYLNGNrWSLGGGTCKALLFMLSLSRG 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 211 LSTYVLVLIGVDRWIAVKYPMKSLNMAK-RCHRLLGG-TYILSLVLSLPQFFIfhvargPFVEEFYQCvtHGFYTAD--- 285
Cdd:cd15199   86 VSIAFLTAVALDRYFRVVHPRGKKNSLSlQAAPYISFlVWLLLVGLTIPTLLA------SQPKNFTEC--NSFSPKDded 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 286 ----WQEQMYATFTLVFTFLLPLCilfgtymsTFRTISSSEKmfqgsklanySTAKLPTQTNRQRLIhkakmkSLRISVV 361
Cdd:cd15199  158 fsdtWQEAVFFLQFLLPFGLIVFC--------TVRIIRRLKK----------RLRDVGKQPKLQRAM------ALVTSVV 213
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 442631927 362 IIiaFLICWTPYYVM-MIMFMFLNPDK----RLGDDLQDAIFFFGMSNSLVNPLIY 412
Cdd:cd15199  214 VV--FGFCFLPCFLArVLMLIFQNKEScnalNIAVHTYDVTMCLTYLNSVLDPIVY 267
7tmA_GPR139 cd15919
G-protein-coupled receptor GPR139, member of the class A family of seven-transmembrane G ...
119-412 2.34e-03

G-protein-coupled receptor GPR139, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR139, a vertebrate orphan receptor, is very closely related to GPR142, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and plays an important role in mediating insulin secretion and maintaining glucose homeostasis, whereas GPR139 is expressed almost exclusively in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139. These orphan receptors are phylogenetically clustered with invertebrate FMRFamide receptors such as Drosophila melanogaster DrmFMRFa-R.


Pssm-ID: 320585 [Multi-domain]  Cd Length: 270  Bit Score: 40.27  E-value: 2.34e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 119 LLKVYVLAVMALFSLLGNLLTIwnIYKTRISRRNSRHTwsaiYSLMFHLSIADVLVTWFCIIGEAAW-CYTVQWLANELT 197
Cdd:cd15919    1 FVPVIYYSLLLCLGLPANILTV--IILSQLVARRQKSS----YNYLLALAAADILVLFFIVFVDFLLeDFILNKQMPQVL 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 198 CKLVKLFQMFSLYLSTYVLVLIGVDRWIAVKYPMK--SLNMAKRCHRLLGGTYILSLVLSLPQFfifhvargpfveeFYQ 275
Cdd:cd15919   75 DKIIEVLEFSSIHTSIWITVPLTIDRYIAVCHPLKyhTVSYPARTRKVIVSVYITCFLTSIPYY-------------WWP 141
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 276 CVTHGFYTADWQEQMYATFTLVFTFLLPLCILFgtymSTFRTISSSEKMFQGSKLANYSTAklptqtnrqrlihkakmKS 355
Cdd:cd15919  142 NIWIEDYTSTSMHHVLIWIHCFTVYLVPCSIFF----VLNSIIVYKLRRKSNFRLRGYSTG-----------------KT 200
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 442631927 356 LRISVVIIIAFLICWTPYYVMMIMFMFLNP--DKRLGDDLQDAIFFFGMSNSLVNPLIY 412
Cdd:cd15919  201 TAILFTITSIFAILWAPRIIMILYHLYVSPinNSWLVHIVSDIANMLALLNTAINFFLY 259
7tmA_GPR26_GPR78-like cd15219
G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G ...
119-382 3.15e-03

G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G protein-coupled receptors; Orphan G-protein coupled receptor 26 (GPR26) and GPR78 are constitutively active and coupled to increased cAMP formation. They are closely related based on sequence homology and comprise a conserved subgroup within the class A G-protein coupled receptor (GPCR) superfamily. Both receptors are widely expressed in selected tissues of the brain but their endogenous ligands are unknown. GPR26 knockout mice showed increased levels of anxiety- and depression-like behaviors, whereas GPR78 has been implicated in susceptibility to bipolar affective disorder and schizophrenia. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320347 [Multi-domain]  Cd Length: 264  Bit Score: 39.75  E-value: 3.15e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 119 LLKVYVLAVMALfSLLGNLLT-IWNIYKTRISRRNSrhtwsAIYSLmfHLSIADVLVTWFCIIGEAAWCYTVQWLANELT 197
Cdd:cd15219    1 LLAVLLVVVLVV-SLLSNLLVlLCFLYSAELRKQVP-----GIFLL--NLSFCNLLLTVLNMPFTLLGVVRNRQPFGDGF 72
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 198 CKLVKLFQMFSLYLSTYVLVLIGVDRWIAVKYPMKSlnMAKRCHR----LLGGTYILSLVLSLPQFFIfhvARGPFVEEF 273
Cdd:cd15219   73 CQAVGFLETFLTSNAMLSMAALSIDRWIAVVFPLSY--TSKMRYRdaalMVGYSWLHSLTFSLVALFL---SWLGYSSLY 147
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 274 YQCVTHGFYTADWQEQM-YATFTLVFTFLLPLCILFGTYMSTFRTisssekmfqgsklanystaklptqTNRQRLIHKak 352
Cdd:cd15219  148 ASCTLHLPREEERRRFAvFTAFFHAFTFLLSLLVLCVTYLKVLKV------------------------RRRQRATKK-- 201
                        250       260       270
                 ....*....|....*....|....*....|
gi 442631927 353 mkslrISvVIIIAFLICWTPYYVMMIMFMF 382
Cdd:cd15219  202 -----IS-IFIGTFVLCFAPYVITRLVELL 225
7tmA_CCR7 cd15175
CC chemokine receptor type 7, member of the class A family of seven-transmembrane G ...
126-318 3.58e-03

CC chemokine receptor type 7, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR7 is a major homeostatic receptor responsible for lymph node development and effective adaptive immune responses and plays a critical role in trafficking of dendritic cells and B and T lymphocytes. Its only two ligands, CCL and CCl21, are primarily produced by stromal cells in the T cell zones of lymph nodes and spleen. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341331 [Multi-domain]  Cd Length: 278  Bit Score: 39.75  E-value: 3.58e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 126 AVMALFSLLGNLLTIWN-IYKTRISrrnsrhTWSAIYslMFHLSIADVLVtwfcIIGEAAWCYTV--QWLANELTCKLVK 202
Cdd:cd15175    8 SVICFLGLLGNGLVILTyIYFKRLK------TMTDIY--LLNLALADILF----LLTLPFWAASAakKWVFGEEMCKAVY 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 203 LFQMFSLYLSTYVLVLIGVDRWIAVkypmkslNMAKRCHRL-----------LGGTYILSLVLSLPQFFIFHVARgpfve 271
Cdd:cd15175   76 CLYKMSFFSGMLLLMCISIDRYFAI-------VQAASAHRHrsravfiskvsSLGVWVLAFILSIPELLYSGVNN----- 143
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 442631927 272 efYQCVTHGFYTADWQEQMYATFT---LVFTFLLPLCILFGTYMSTFRTI 318
Cdd:cd15175  144 --NDGNGTCSIFTNNKQTLSVKIQisqMVLGFLVPLVVMSFCYSVIIKTL 191
7tmA_TAAR5 cd15318
trace amine-associated receptor 5, member of the class A family of seven-transmembrane G ...
123-416 3.62e-03

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 5 is one of the 15 identified amine-activated G protein-coupled receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320441 [Multi-domain]  Cd Length: 282  Bit Score: 39.84  E-value: 3.62e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 123 YVLAVMALFSLLGNLLTIWNIyktriSRRNSRHTWSAIysLMFHLSIADVL----VTWFCIIGEAAWCytvqWLANELTC 198
Cdd:cd15318    5 LACAIGMLIIVLGNLFVVVTV-----SHFKALHTPTNF--LLLSLALADMLlgltVLPFSTIRSVESC----WYFGDSFC 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 199 KLVKLFQMFSLYLSTYVLVLIGVDRWIAV----KYPMK-SLNMAKRChrlLGGTYILSLVLSLPQFFIFHVARG--PFVE 271
Cdd:cd15318   74 RLHTCLDTLFCLTSIFHLCFISIDRHCAIcdplLYPSKfTIRVACIF---IAAGWLVPTVYTSVFLYTKAVEEGlaELLT 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 272 EFyQCV--THGFYTADWQeqmYATFTLvftFLLPLCILFGTYMstfrtissseKMFQGSKLANYSTAKLPTQTNRQRLIH 349
Cdd:cd15318  151 SV-PCVgsCQLLYNKLWG---WLNFPV---FFIPCLIMIGLYV----------KIFIVAKRQARAIASLLSDTNGASKRE 213
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 350 KAKMKSLRISVVIiiaFLICWTPYYVMMIMFMFLN---PDKrlgddLQDAIFFFGMSNSLVNPLIYGAFH 416
Cdd:cd15318  214 RKAAKTLGIAVGV---YLLCWLPFTIDTMVDSLLNfitPPL-----LFDIIIWFAYFNSACNPLIYVFSY 275
7tmA_RNL3R1 cd15926
relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G ...
124-372 3.71e-03

relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R1 is also known as GPCR135, relaxin family peptide receptor 3 (RXFP3), and somatostatin- and angiotensin-like peptide receptor (SALPR). RNL3/relaxin-3, a member of the insulin superfamily, is an endogenous neuropeptide ligand for RNL3R1. RNL3R1 is predominantly expressed in brain regions and implicated in stress, anxiety, and feeding, and metabolism. RNL3R1 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation, and also activates Erk1/2 signaling pathway.


Pssm-ID: 320592 [Multi-domain]  Cd Length: 288  Bit Score: 39.88  E-value: 3.71e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 124 VLAVMALFSLLGNLLTIWnIYKTRISRRNSrhtwsAIYSLMFHLSIAD---VLVTWFCIIGEAawcYTVQWLANELTCKL 200
Cdd:cd15926    6 VYSVVCALGLVGNLLVLY-LMKSKQGWKKS-----SINLFVTSLAVTDfqfVLTLPFWAVENA---LDFTWLFGKAMCKI 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 201 VKLFQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLNMAKRCHR--LLGGTYILSLVLSLPQfFIFHVARGPFVEEFyqCVT 278
Cdd:cd15926   77 VSYVTAMNMYASVFFLTAMSVARYHSVASALKSKRRRGCCSAkwLCVLIWVLAILASLPN-AIFSTTATVSNEEL--CLV 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 279 H---GFYTADWQEQMYATFTLVFTFLLPLCILFGTYMSTFRTIsssekmfqgsklanysTAKLPTQTNRQRlihkaKMKS 355
Cdd:cd15926  154 KfpdNRGNAQFWLGLYHAQKVLLGFLIPLGIISLCYLLLVRFI----------------TDKNITGSSTKR-----RSKV 212
                        250
                 ....*....|....*..
gi 442631927 356 LRISVVIIIAFLICWTP 372
Cdd:cd15926  213 TKSVTIVVLSFFLCWLP 229
7tmA_mAChR_M4 cd15298
muscarinic acetylcholine receptor subtype M4, member of the class A family of ...
124-413 6.44e-03

muscarinic acetylcholine receptor subtype M4, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to G(i/o) types of G proteins. The M4 receptor is mainly found in the CNS and function as an inhibitory autoreceptor regulating acetycholine release. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341344 [Multi-domain]  Cd Length: 262  Bit Score: 38.85  E-value: 6.44e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 124 VLAVMALFSLLGNLLTIWNIyktrisrRNSRHTWSAIYSLMFHLSIADVLVTWFCIIGEAAWCYTVQWLANELTCKLVKL 203
Cdd:cd15298    6 VTGSLSLVTVVGNILVMLSI-------KVNRQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLA 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 204 FQMFSLYLSTYVLVLIGVDRWIAVKYPMK--SLNMAKRCHRLLGGTYILSLVLSLPQFFIFHVARGPFVEEFYQCVTHgf 281
Cdd:cd15298   79 LDYVVSNASVMNLLIISFDRYFCVTKPLTypARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPDNQCFIQ-- 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 282 ytadWQEQMYATF-TLVFTFLLPLCILFGTYMStFRTISSSEKmfqgsklanystaklptqtnrqrlihkakmKSLRISV 360
Cdd:cd15298  157 ----FLSNPAVTFgTAIAAFYLPVVIMTVLYIH-ISLASARER------------------------------KVTRTIF 201
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 442631927 361 VIIIAFLICWTPYYVMMIMFMFLnpDKRLGDDLQDAIFFFGMSNSLVNPLIYG 413
Cdd:cd15298  202 AILLAFILTWTPYNVMVLVNTFC--QSCIPDTVWSIGYWLCYVNSTINPACYA 252
7tmA_P2Y12 cd15150
P2Y purinoceptor 12, member of the class A family of seven-transmembrane G protein-coupled ...
169-418 6.83e-03

P2Y purinoceptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y12 receptor (P2Y12R) is found predominantly on the surface of blood platelets and is activated by adenosine diphosphate (ADP). P2Y12R plays an important role in the regulation of blood clotting and belongs to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14).


Pssm-ID: 341326  Cd Length: 285  Bit Score: 39.03  E-value: 6.83e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 169 IADVLVTW---FCIIGEAAwcyTVQWLANELTCKLVKLFQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLNMAKRCHR--L 243
Cdd:cd15150   43 ISDLLMILtfpFKILSDAK---LGSWPLRGFVCQVTSVIFYFTMYISILFLGLITIDRYQKTTRPFKTSNPKNLLGAkiL 119
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 244 LGGTYILSLVLSLPQFFIfhVARGPFVEEFYQC-VTHGFYTADWQEqmYATFTLVFTFLLPLCILFGTYMSTFRTISSSE 322
Cdd:cd15150  120 STVIWASMFALSLPNMIL--TNRQPTPKNVKKCsLLKSEFGLVWHE--IVNYICQVIFWVNFLIVIVCYTLITKELYKSY 195
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 323 KmfqgsklanystaklptqtnRQRLIHKAKMKSLRISVVIIIA-FLICWTPYYVMMIMF-------MFLNPDKRLGDDLQ 394
Cdd:cd15150  196 K--------------------RTRGVGKVSRKKVNVKVFIIIAvFFICFVPFHFARIPYtlsqtrdVFDCTAKNTLFYVK 255
                        250       260
                 ....*....|....*....|....
gi 442631927 395 DAIFFFGMSNSLVNPLIYgaFHLC 418
Cdd:cd15150  256 ESTLWLTSLNACLDPFIY--FFLC 277
7tmA_TSH-R cd15964
thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family ...
118-257 7.21e-03

thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. TSH-R plays an important role thyroid physiology, and its activation stimulates the production of thyroxine (T4) and triiodothyronine (T3). Defects in TSH-R are a cause of several types of hyperthyroidism. The receptor is predominantly found on the surface of the thyroid epithelial cells and couples to the G(s)-protein and activates adenylate cyclase, thereby promoting cAMP production. TSH and cAMP stimulate thyroid cell proliferation, differentiation, and function.


Pssm-ID: 320630 [Multi-domain]  Cd Length: 275  Bit Score: 38.73  E-value: 7.21e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 118 GLLKVYVLAVmALFSLLGN----LLTIWNIYKTRISRrnsrhtwsaiySLMFHLSIADVLVTWFCIIGEAAWCYT----- 188
Cdd:cd15964    1 KFLRIVVWFV-NLLAILGNvfvlLILLTSHYKLTVPR-----------FLMCNLAFADFCMGIYLLLIASVDLHTrseyy 68
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 442631927 189 ---VQWLANElTCKLVKLFQMFSLYLSTYVLVLIGVDRWIAVKYPM---KSLNMAKRCHRLLGGTYILSLVLSLP 257
Cdd:cd15964   69 nhaIDWQTGP-GCNTAGFFTVFASELSVYTLTVITLERWYAITFAMrldRKIRLRHASAIMLGGWVFCFLLALLP 142
7tmA_LWS_opsin cd15081
long wave-sensitive opsins, member of the class A family of seven-transmembrane G ...
289-412 7.35e-03

long wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Long Wave-Sensitive opsin is also called red-sensitive opsin or red cone photoreceptor pigment, which mediates visual transduction in response to light at long wavelengths. Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320209 [Multi-domain]  Cd Length: 292  Bit Score: 38.74  E-value: 7.35e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 289 QMYATFTLVFTFLLPLCILFGTYMSTFRTISSSEKmfqgsklanystaklptQTNRQRLIHKAKMKSLRISVVIIIAFLI 368
Cdd:cd15081  176 QSYMIVLMITCCIIPLAIIILCYLQVWLAIRAVAQ-----------------QQKESESTQKAEKEVSRMVVVMIFAYCF 238
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 442631927 369 CWTPyYVMMIMFMFLNPDKRLGDDLQDAIFFFGMSNSLVNPLIY 412
Cdd:cd15081  239 CWGP-YTFFACFAAANPGYAFHPLAAALPAYFAKSATIYNPIIY 281
7tmA_S1PR4_Edg6 cd15349
sphingosine-1-phosphate receptor subtype 4 (S1PR4 or S1P4), also called endothelial ...
291-412 9.39e-03

sphingosine-1-phosphate receptor subtype 4 (S1PR4 or S1P4), also called endothelial differentiation gene 6 (Edg6), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320471 [Multi-domain]  Cd Length: 271  Bit Score: 38.61  E-value: 9.39e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 291 YATFTLVFTFLLPLCILfGTYMSTFRTISSSekmfqgsklanysTAKLPTQTNRQRLIHKakmksLRISVVIIIAFLICW 370
Cdd:cd15349  158 YILFCLVIFFIILLTII-GLYFAIYCLVRAS-------------GQRVISARSRRRSLRL-----LKTVLMILGAFMVCW 218
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 442631927 371 TPYYVMMIMFMFLNPDKRLGDDLQDAIFFFGMSNSLVNPLIY 412
Cdd:cd15349  219 GPLFILLLVDFFCSSRSCKPLFGMEWVLALAVLNSAINPLIY 260
7tmA_PAR4 cd15372
protease-activated receptor 4, member of the class A family of seven-transmembrane G ...
191-412 9.65e-03

protease-activated receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320494 [Multi-domain]  Cd Length: 274  Bit Score: 38.58  E-value: 9.65e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 191 WLANELTCKLVKLFQMFSLYLSTYVLVLIGVDRWIAVKYPMKSlnMAKRCHRLLGGTYILSLVLSLPQFFIFHVARGPFV 270
Cdd:cd15372   65 WPFGEGLCRVVTAFFYGNMYCSVLLLMCISLDRYLAVVHPFFA--RTLRSRRFALCMCTAIWLIAAALTLPLTLQRQSYP 142
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 271 EEFYQCVT-HGFYTADWQE---QMYATFTLVFTFLLPLCILFGTYMSTFRTISSsekmfqgsklanystaklptqtNRQR 346
Cdd:cd15372  143 LERLNITLcHDVLPLDEQDtylFYYFACLAVLGFLLPLVVILFCYGSVLHTLLR----------------------SGQR 200
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 442631927 347 LIHkakmkSLRISVVIIIAFLICWTPYYVMMIMfMFLNPDKRLGDDLQDAIFF---FGMSNSLVNPLIY 412
Cdd:cd15372  201 YGH-----AMKLTVLVLVSFVLCFTPSNLLLLL-HYSDPTLDDGGNLYIVYMVslaISTLNSCVDPFIY 263
7tmA_GPR37 cd15127
G protein-coupled receptor 37, member of the class A family of seven-transmembrane G ...
162-261 9.68e-03

G protein-coupled receptor 37, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR37, also called parkin-associated endothelin-like receptor (Pael-R), was isolated from a set of human brain frontal lobe expressed sequence tags. It is highly expressed in the mammalian CNS. It is a substrate of parkin and is involved in the pathogenesis of Parkinson's disease. GPR37 has recently been shown to act as a receptor for the neuropeptide prosaptide, the active fragment of the secreted neuroprotective and glioprotective factor prosaposin (also called sulfated glycoprotein-1). Both prosaptide and prosaposin protect primary astrocytes against oxidative stress. GPR37 is part of the class A family of GPCRs that includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320255 [Multi-domain]  Cd Length: 298  Bit Score: 38.68  E-value: 9.68e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631927 162 SLMFHLSIADVLVTWFCIIGEAAWCYTVQWLANELTCKLVKLFQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLNMAKRCH 241
Cdd:cd15127   37 SLLANLAFWDFLIIFFCLPLVIFHELTKKWLLGDFSCKIVPYIEVASLGVTTFTLCALCIDRFRAATNVQMYYEMIENCT 116
                         90       100
                 ....*....|....*....|...
gi 442631927 242 RL---LGGTYILSLVLSLPQFFI 261
Cdd:cd15127  117 STtakLAVIWVGALLLALPEVVL 139
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH