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    Nhe3 Na[+]/H[+] hydrogen exchanger 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33939, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nhe3provided by FlyBase
    Official Full Name
    Na[+]/H[+] hydrogen exchanger 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0028703
    Locus tag
    Dmel_CG11328
    See related
    AllianceGenome:FB:FBgn0028703
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11328; Dmel\CG11328; DmNHE3; NHE; nhe3; NHE3
    Summary
    Predicted to enable potassium:proton antiporter activity and sodium:proton antiporter activity. Predicted to be involved in potassium ion transmembrane transport; regulation of intracellular pH; and sodium ion import across plasma membrane. Located in perinuclear region of cytoplasm. Is expressed in adult central nervous system; adult head; and organism. Human ortholog(s) of this gene implicated in Christianson syndrome; X-linked intellectual developmental disorder 108; and autistic disorder. Orthologous to several human genes including SLC9A9 (solute carrier family 9 member A9). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Nhe3 in Genome Data Viewer
    Location:
    26F7-26F7; 2-21 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (6677835..6684364, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (6677835..6684364, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene cup Neighboring gene cortex Neighboring gene Non-SMC element 1 Neighboring gene uncharacterized protein Neighboring gene Thrombospondin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The splicing of U12-type introns can be a rate-limiting step in gene expression. Patel AA, et al. EMBO J, 2002 Jul 15. PMID 12110592, Free PMC Article
    2. Autism sensory dysfunction in an evolutionarily conserved system. Vilidaite G, et al. Proc Biol Sci, 2018 Dec 19. PMID 30963913, Free PMC Article
    3. A thrombospondin homologue in Drosophila melanogaster: cDNA and protein structure. Adolph KW. Gene, 2001 May 16. PMID 11376949
    4. Evolutionary origins of eukaryotic sodium/proton exchangers. Brett CL, et al. Am J Physiol Cell Physiol, 2005 Feb. PMID 15643048
    5. Chemical Genetic Screen in Drosophila Germline Uncovers Small Molecule Drugs That Sensitize Stem Cells to Insult-Induced Apoptosis. Ishibashi JR, et al. Cells, 2021 Oct 16. PMID 34685753, Free PMC Article

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables potassium:proton antiporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sodium:proton antiporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sodium:proton antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of intracellular pH IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of pH IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sodium ion import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sodium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in recycling endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Na[+]/H[+] hydrogen exchanger 3
    Names
    CG11328-PD
    CG11328-PE
    CG11328-PG
    CG11328-PH
    CG11328-PI
    CG11328-PJ
    Na+/H+ hydrogen exchanger 3
    Nhe3-PD
    Nhe3-PE
    Nhe3-PG
    Nhe3-PH
    Nhe3-PI
    Nhe3-PJ

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      6677835..6684364 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001103635.3 → NP_001097105.3  Na[+]/H[+] hydrogen exchanger 3, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097105.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8DYW5, Q9U624
      Conserved Domains (1) summary
      COG0025
      Location:150 → 515
      NhaP; NhaP-type Na+/H+ or K+/H+ antiporter [Inorganic ion transport and metabolism]

    2. NM_001144329.2 → NP_001137801.1  Na[+]/H[+] hydrogen exchanger 3, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137801.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7Z029, Q9U624
      Conserved Domains (1) summary
      COG0025
      Location:150 → 515
      NhaP; NhaP-type Na+/H+ or K+/H+ antiporter [Inorganic ion transport and metabolism]

    3. NM_135220.3 → NP_609064.3  Na[+]/H[+] hydrogen exchanger 3, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609064.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U624, Q9VM99
      Conserved Domains (1) summary
      COG0025
      Location:150 → 515
      NhaP; NhaP-type Na+/H+ or K+/H+ antiporter [Inorganic ion transport and metabolism]

    4. NM_001273218.1 → NP_001260147.1  Na[+]/H[+] hydrogen exchanger 3, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260147.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PB53, Q9U624
      Conserved Domains (1) summary
      COG0025
      Location:150 → 515
      NhaP; NhaP-type Na+/H+ or K+/H+ antiporter [Inorganic ion transport and metabolism]

    5. NM_164701.2 → NP_723202.2  Na[+]/H[+] hydrogen exchanger 3, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723202.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      B5RIF8, Q8IPJ4
      Conserved Domains (1) summary
      TIGR00840
      Location:155 → 531
      b_cpa1; sodium/hydrogen exchanger 3

    6. NM_001273217.1 → NP_001260146.1  Na[+]/H[+] hydrogen exchanger 3, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260146.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D5SHT8, Q5U1C5
      Conserved Domains (1) summary
      COG0025
      Location:57 → 422
      NhaP; NhaP-type Na+/H+ or K+/H+ antiporter [Inorganic ion transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A8DYW5 A8DYW5
    B7Z029 B7Z029
    D5SHT8 D5SHT8
    M9PB53 M9PB53
    Q8IPJ4 Q8IPJ4
    Q9U624 Q9U624
    Q9VM99 Q9VM99

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