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Conserved domains on  [gi|281364513|ref|NP_001097105|]
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Na[+]/H[+] hydrogen exchanger 3, isoform H [Drosophila melanogaster]

Protein Classification

cation:proton antiporter family protein( domain architecture ID 3846)

cation:proton antiporter family protein functions in maintaining cation homeostasis and the pH of actively metabolizing cells; it may also be involved in regulating cell volume

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Na_H_Exchanger super family cl01133
Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH ...
155-533 3.05e-92

Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH of actively metabolising cells. The molecular mechanisms of antiport are unclear. These antiporters contain 10-12 transmembrane regions (M) at the amino-terminus and a large cytoplasmic region at the carboxyl terminus. The transmembrane regions M3-M12 share identity with other members of the family. The M6 and M7 regions are highly conserved. Thus, this is thought to be the region that is involved in the transport of sodium and hydrogen ions. The cytoplasmic region has little similarity throughout the family.


The actual alignment was detected with superfamily member TIGR00840:

Pssm-ID: 470090 [Multi-domain]  Cd Length: 559  Bit Score: 297.46  E-value: 3.05e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281364513  155 TFDPEVFFNIILPPIIFYAGYSLKKKYFFRNLGAILTFAIVGTTLSAFLIGGFMYGcVKLMPKYLSSSFTFLDSLYFGAL 234
Cdd:TIGR00840  62 TLDSSYFFLYLLPPIVLDAGYFMPQRNFFENLGSILIFAVVGTLINAFVIGLSLYG-ICLIGGFGSIDIGLLDNLLFGSL 140
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281364513  235 ISPTDPLTILAIFNDLRVDVNLYALVLGESVLNDAVAIVLSGAIQNYgeHYSNTGEFETTAFLRSLSDFFSIFLLSLMIG 314
Cdd:TIGR00840 141 ISAVDPVAVLAVFEEYHVNEKLYIIIFGESLLNDAVTVVLYNTFIKF--HKTADEPVTIVDVFEGCASFFVVTCGGLLVG 218
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281364513  315 AAMGCLTALMTKFTRVRDfpLLESALFVLMSYSTFLLAEATELTGVVAVLFCGICQAHYTYNNLSEDSRQRTKQIFELLN 394
Cdd:TIGR00840 219 VVFGFLVAFITRFTHHIR--QIEPLFVFLISYLSYLFAETLHLSGILALIFCGITMKKYVEANMSRRSQTTIKYFMKMLS 296
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281364513  395 FLAENFIFSYIGVSMFTfPKHHFDAGFIITAFICAAIGRAVNVYPLSWLLNIKRKPKISTNFQHMLFFAGLRGAMSFALA 474
Cdd:TIGR00840 297 SLSETLIFIFLGVSLVT-ENHEWNWAFVVATLSFCVIYRVLGVRTLSWITNEFRPVEIPYKDQLVIFYAGLRGAVAFALA 375
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 281364513  475 --IRNTVSDERQTMLTATSLIVIFTVVIQGGAANFLLNWLKIPvgVDDETEQLNNYQVHSD 533
Cdd:TIGR00840 376 llLDEKIFPYKFLFVTTTLVVVFFTVIFQGGTIKPLVEVLKVK--KGCISKTKINEELHDR 434
 
Name Accession Description Interval E-value
b_cpa1 TIGR00840
sodium/hydrogen exchanger 3; The Monovalent Cation:Proton Antiporter-1 (CPA1) Family (TC 2.A. ...
155-533 3.05e-92

sodium/hydrogen exchanger 3; The Monovalent Cation:Proton Antiporter-1 (CPA1) Family (TC 2.A.36)The CPA1 family is a large family of proteins derived from Gram-positive and Gram-negative bacteria, blue green bacteria, yeast, plants and animals.Transporters from eukaryotes have been functionally characterized, and all of these catalyze Na+:H+ exchange. Their primary physiological functions may be in(1) cytoplasmic pH regulation, extruding the H+ generated during metabolism, and (2) salt tolerance (in plants), due to Na+ uptake into vacuoles.This model is specific for the eukaryotic members members of this family. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273294 [Multi-domain]  Cd Length: 559  Bit Score: 297.46  E-value: 3.05e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281364513  155 TFDPEVFFNIILPPIIFYAGYSLKKKYFFRNLGAILTFAIVGTTLSAFLIGGFMYGcVKLMPKYLSSSFTFLDSLYFGAL 234
Cdd:TIGR00840  62 TLDSSYFFLYLLPPIVLDAGYFMPQRNFFENLGSILIFAVVGTLINAFVIGLSLYG-ICLIGGFGSIDIGLLDNLLFGSL 140
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281364513  235 ISPTDPLTILAIFNDLRVDVNLYALVLGESVLNDAVAIVLSGAIQNYgeHYSNTGEFETTAFLRSLSDFFSIFLLSLMIG 314
Cdd:TIGR00840 141 ISAVDPVAVLAVFEEYHVNEKLYIIIFGESLLNDAVTVVLYNTFIKF--HKTADEPVTIVDVFEGCASFFVVTCGGLLVG 218
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281364513  315 AAMGCLTALMTKFTRVRDfpLLESALFVLMSYSTFLLAEATELTGVVAVLFCGICQAHYTYNNLSEDSRQRTKQIFELLN 394
Cdd:TIGR00840 219 VVFGFLVAFITRFTHHIR--QIEPLFVFLISYLSYLFAETLHLSGILALIFCGITMKKYVEANMSRRSQTTIKYFMKMLS 296
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281364513  395 FLAENFIFSYIGVSMFTfPKHHFDAGFIITAFICAAIGRAVNVYPLSWLLNIKRKPKISTNFQHMLFFAGLRGAMSFALA 474
Cdd:TIGR00840 297 SLSETLIFIFLGVSLVT-ENHEWNWAFVVATLSFCVIYRVLGVRTLSWITNEFRPVEIPYKDQLVIFYAGLRGAVAFALA 375
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 281364513  475 --IRNTVSDERQTMLTATSLIVIFTVVIQGGAANFLLNWLKIPvgVDDETEQLNNYQVHSD 533
Cdd:TIGR00840 376 llLDEKIFPYKFLFVTTTLVVVFFTVIFQGGTIKPLVEVLKVK--KGCISKTKINEELHDR 434
Na_H_Exchanger pfam00999
Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH ...
155-511 6.98e-57

Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH of actively metabolising cells. The molecular mechanisms of antiport are unclear. These antiporters contain 10-12 transmembrane regions (M) at the amino-terminus and a large cytoplasmic region at the carboxyl terminus. The transmembrane regions M3-M12 share identity with other members of the family. The M6 and M7 regions are highly conserved. Thus, this is thought to be the region that is involved in the transport of sodium and hydrogen ions. The cytoplasmic region has little similarity throughout the family.


Pssm-ID: 425982 [Multi-domain]  Cd Length: 377  Bit Score: 197.86  E-value: 6.98e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281364513  155 TFDPEVFFNIILPPIIFYAGYSLKKKYFFRNLGAILTFAIVGTTLSAFLIGGFMYgcvklmpkYLSSSFTFLDSLYFGAL 234
Cdd:pfam00999  45 DEDLEVLSNLGLPPLLFLAGLELDLRELRKNGGSILLLALLGVLIPFVLIGLLLY--------LLGLGIPLLEALLFGAI 116
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281364513  235 ISPTDPLTILAIFNDL-RVDVNLYALVLGESVLNDAVAIVLSGAIQNYGEHysNTGEFETTAFLRSlsdFFSIFLLSLMI 313
Cdd:pfam00999 117 LSATSPVVVLAILKELgRVPERLGTLLLGESVLNDGVAVVLLAVLLALAQG--VGGGSDLGWLLLI---FLVVAVGGLLL 191
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281364513  314 GAAMGCLTALMTKFTrvRDFPLLESALFVLMSYSTFLLAEATELTGVVAVLFCGICQAHYTYNN-LSEDSRQrtkqifeL 392
Cdd:pfam00999 192 GLLIGWLLRLITRFT--DDDRELEVLLVLLLALLAALLAEALGVSGILGAFLAGLVLSEYPFANkLSEKLEP-------F 262
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281364513  393 LNFLAENFIFSYIGVSMFTFPKHHFDAGFIITAFICAAIGRAVNVYPLSWLLnikrkpKISTNFQHMLFFAGL-RGAMSF 471
Cdd:pfam00999 263 GYGLFNPLFFVLVGLSLDLSSLLLSVWILVLLALVAILLGRFLGVFLLLRLL------GLSLREALIIGFGGLqRGAVSL 336
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|..
gi 281364513  472 ALAIR--NTVSDERQtMLTATSLIVIFTVVIQGGAANFLLNW 511
Cdd:pfam00999 337 ALAAIgpLLGIIARE-LYPLLIVVVLFTVLVQGITLKPLLFK 377
NhaP COG0025
NhaP-type Na+/H+ or K+/H+ antiporter [Inorganic ion transport and metabolism];
152-515 7.10e-56

NhaP-type Na+/H+ or K+/H+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 439796 [Multi-domain]  Cd Length: 506  Bit Score: 198.65  E-value: 7.10e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281364513 152 LKATFDPEV-----FFNIILPPIIFYAGYSLKKKYFFRNLGAILTFAIVGTTLSAFLIGGFMYgcvklmpkYLSSsFTFL 226
Cdd:COG0025   43 LGLELDPELgdlepLLELFLPPLLFEAALNLDLRELRRNGRPILRLAVVGVLLTTLAVALAAH--------WLLG-LPLA 113
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281364513 227 DSLYFGALISPTDPLTILAIFNDLRVDVNLYALVLGESVLNDAVAIVL----SGAIQnygehysnTGEFettAFLRSLSD 302
Cdd:COG0025  114 AALLLGAILAPTDPVAVSPILRRLGVPKRLRTILEGESLLNDATALVLfvlaLAAAL--------GGGF---SLGEALLD 182
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281364513 303 FFSIFLLSLMIGAAMGCLTALMtkFTRVRDfPLLESALFVLMSYSTFLLAEATELTGVVAVLFCGICQAHYTYNNLSEDS 382
Cdd:COG0025  183 FLLAILGGILVGLLLGWLLGRL--LRRLPD-PLLEILLTLALPFLAYLLAEALHGSGVLAVVVAGLVLGNAGRRSLSPET 259
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281364513 383 RQRTKQIFELLNFLAENFIFSYIGVSMFTFPKHHFDAGFIITAFICAAIGRAVNVYPLSWLlnikRKPKISTNFQHMLFF 462
Cdd:COG0025  260 RLQLLEFWETLEFLLNSLLFVLLGAQLPLILLGALGLGGILLVLLALLVVRPLWVFLSLAL----RGSRLSWRERLFLSW 335
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 281364513 463 AGLRGAMSFALA-----IRNTVSDERQTMLTATSLIVIFTVVIQGGAANFLLNWLKIP 515
Cdd:COG0025  336 GGPRGIVSLALAlslplHGGAGFPGRDLILALAFGVILLTLVLQGLTLPPLARRLGLR 393
PRK05326 PRK05326
potassium/proton antiporter;
169-534 1.68e-04

potassium/proton antiporter;


Pssm-ID: 235410 [Multi-domain]  Cd Length: 562  Bit Score: 44.81  E-value: 1.68e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281364513 169 IIFYAGYSLKKKYFFRNLGAILTFAIVGTTLSAFLIGGFMYgcvklmpkYLSSsFTFLDSLYFGALISPTDPltiLAIFN 248
Cdd:PRK05326  70 ILFDGGLRTRWSSFRPALGPALSLATLGVLITAGLTGLFAH--------WLLG-LDWLEGLLLGAIVGSTDA---AAVFS 137
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281364513 249 DLR-VDVNLY----ALVLGESVLNDAVA----IVLSGAIQNygehysntgeFETTAFLRSLSDFFSIFLLSLMIGAAMGC 319
Cdd:PRK05326 138 LLRgKGLNLKervaSTLEIESGSNDPMAvfltITLIELITG----------GETGLSWGFLLLFLQQFGLGALIGLLGGW 207
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281364513 320 LTALMtkftrVRDFPLLESALFVLMSYS----TFLLAEATELTGVVAVLFCGIcqahyTYNNLSEDSRQRTKQIFELLNF 395
Cdd:PRK05326 208 LLVQL-----LNRIALPAEGLYPILVLAgallIFALTAALGGSGFLAVYLAGL-----VLGNRPIRHRHSILRFFDGLAW 277
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281364513 396 LAENFIFSYIGvsMFTFPKHHFDAgfIITAFICAA----IGRAVNVYPLSWLLNIKRKPKIstnfqhMLFFAGLRGAMSF 471
Cdd:PRK05326 278 LAQIGMFLVLG--LLVTPSRLLDI--ALPALLLALflilVARPLAVFLSLLPFRFNLREKL------FISWVGLRGAVPI 347
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 281364513 472 ALAI---RNTVSDErQTMLTATSLIVIFTVVIQGGAANFLLNWLkipvGVDDETEQLNNYQVHSDV 534
Cdd:PRK05326 348 VLATfpmMAGLPNA-QLIFNVVFFVVLVSLLLQGTTLPWAARKL----GVVVPPEARPVSRVELDP 408
 
Name Accession Description Interval E-value
b_cpa1 TIGR00840
sodium/hydrogen exchanger 3; The Monovalent Cation:Proton Antiporter-1 (CPA1) Family (TC 2.A. ...
155-533 3.05e-92

sodium/hydrogen exchanger 3; The Monovalent Cation:Proton Antiporter-1 (CPA1) Family (TC 2.A.36)The CPA1 family is a large family of proteins derived from Gram-positive and Gram-negative bacteria, blue green bacteria, yeast, plants and animals.Transporters from eukaryotes have been functionally characterized, and all of these catalyze Na+:H+ exchange. Their primary physiological functions may be in(1) cytoplasmic pH regulation, extruding the H+ generated during metabolism, and (2) salt tolerance (in plants), due to Na+ uptake into vacuoles.This model is specific for the eukaryotic members members of this family. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273294 [Multi-domain]  Cd Length: 559  Bit Score: 297.46  E-value: 3.05e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281364513  155 TFDPEVFFNIILPPIIFYAGYSLKKKYFFRNLGAILTFAIVGTTLSAFLIGGFMYGcVKLMPKYLSSSFTFLDSLYFGAL 234
Cdd:TIGR00840  62 TLDSSYFFLYLLPPIVLDAGYFMPQRNFFENLGSILIFAVVGTLINAFVIGLSLYG-ICLIGGFGSIDIGLLDNLLFGSL 140
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281364513  235 ISPTDPLTILAIFNDLRVDVNLYALVLGESVLNDAVAIVLSGAIQNYgeHYSNTGEFETTAFLRSLSDFFSIFLLSLMIG 314
Cdd:TIGR00840 141 ISAVDPVAVLAVFEEYHVNEKLYIIIFGESLLNDAVTVVLYNTFIKF--HKTADEPVTIVDVFEGCASFFVVTCGGLLVG 218
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281364513  315 AAMGCLTALMTKFTRVRDfpLLESALFVLMSYSTFLLAEATELTGVVAVLFCGICQAHYTYNNLSEDSRQRTKQIFELLN 394
Cdd:TIGR00840 219 VVFGFLVAFITRFTHHIR--QIEPLFVFLISYLSYLFAETLHLSGILALIFCGITMKKYVEANMSRRSQTTIKYFMKMLS 296
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281364513  395 FLAENFIFSYIGVSMFTfPKHHFDAGFIITAFICAAIGRAVNVYPLSWLLNIKRKPKISTNFQHMLFFAGLRGAMSFALA 474
Cdd:TIGR00840 297 SLSETLIFIFLGVSLVT-ENHEWNWAFVVATLSFCVIYRVLGVRTLSWITNEFRPVEIPYKDQLVIFYAGLRGAVAFALA 375
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 281364513  475 --IRNTVSDERQTMLTATSLIVIFTVVIQGGAANFLLNWLKIPvgVDDETEQLNNYQVHSD 533
Cdd:TIGR00840 376 llLDEKIFPYKFLFVTTTLVVVFFTVIFQGGTIKPLVEVLKVK--KGCISKTKINEELHDR 434
Na_H_Exchanger pfam00999
Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH ...
155-511 6.98e-57

Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH of actively metabolising cells. The molecular mechanisms of antiport are unclear. These antiporters contain 10-12 transmembrane regions (M) at the amino-terminus and a large cytoplasmic region at the carboxyl terminus. The transmembrane regions M3-M12 share identity with other members of the family. The M6 and M7 regions are highly conserved. Thus, this is thought to be the region that is involved in the transport of sodium and hydrogen ions. The cytoplasmic region has little similarity throughout the family.


Pssm-ID: 425982 [Multi-domain]  Cd Length: 377  Bit Score: 197.86  E-value: 6.98e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281364513  155 TFDPEVFFNIILPPIIFYAGYSLKKKYFFRNLGAILTFAIVGTTLSAFLIGGFMYgcvklmpkYLSSSFTFLDSLYFGAL 234
Cdd:pfam00999  45 DEDLEVLSNLGLPPLLFLAGLELDLRELRKNGGSILLLALLGVLIPFVLIGLLLY--------LLGLGIPLLEALLFGAI 116
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281364513  235 ISPTDPLTILAIFNDL-RVDVNLYALVLGESVLNDAVAIVLSGAIQNYGEHysNTGEFETTAFLRSlsdFFSIFLLSLMI 313
Cdd:pfam00999 117 LSATSPVVVLAILKELgRVPERLGTLLLGESVLNDGVAVVLLAVLLALAQG--VGGGSDLGWLLLI---FLVVAVGGLLL 191
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281364513  314 GAAMGCLTALMTKFTrvRDFPLLESALFVLMSYSTFLLAEATELTGVVAVLFCGICQAHYTYNN-LSEDSRQrtkqifeL 392
Cdd:pfam00999 192 GLLIGWLLRLITRFT--DDDRELEVLLVLLLALLAALLAEALGVSGILGAFLAGLVLSEYPFANkLSEKLEP-------F 262
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281364513  393 LNFLAENFIFSYIGVSMFTFPKHHFDAGFIITAFICAAIGRAVNVYPLSWLLnikrkpKISTNFQHMLFFAGL-RGAMSF 471
Cdd:pfam00999 263 GYGLFNPLFFVLVGLSLDLSSLLLSVWILVLLALVAILLGRFLGVFLLLRLL------GLSLREALIIGFGGLqRGAVSL 336
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|..
gi 281364513  472 ALAIR--NTVSDERQtMLTATSLIVIFTVVIQGGAANFLLNW 511
Cdd:pfam00999 337 ALAAIgpLLGIIARE-LYPLLIVVVLFTVLVQGITLKPLLFK 377
NhaP COG0025
NhaP-type Na+/H+ or K+/H+ antiporter [Inorganic ion transport and metabolism];
152-515 7.10e-56

NhaP-type Na+/H+ or K+/H+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 439796 [Multi-domain]  Cd Length: 506  Bit Score: 198.65  E-value: 7.10e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281364513 152 LKATFDPEV-----FFNIILPPIIFYAGYSLKKKYFFRNLGAILTFAIVGTTLSAFLIGGFMYgcvklmpkYLSSsFTFL 226
Cdd:COG0025   43 LGLELDPELgdlepLLELFLPPLLFEAALNLDLRELRRNGRPILRLAVVGVLLTTLAVALAAH--------WLLG-LPLA 113
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281364513 227 DSLYFGALISPTDPLTILAIFNDLRVDVNLYALVLGESVLNDAVAIVL----SGAIQnygehysnTGEFettAFLRSLSD 302
Cdd:COG0025  114 AALLLGAILAPTDPVAVSPILRRLGVPKRLRTILEGESLLNDATALVLfvlaLAAAL--------GGGF---SLGEALLD 182
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281364513 303 FFSIFLLSLMIGAAMGCLTALMtkFTRVRDfPLLESALFVLMSYSTFLLAEATELTGVVAVLFCGICQAHYTYNNLSEDS 382
Cdd:COG0025  183 FLLAILGGILVGLLLGWLLGRL--LRRLPD-PLLEILLTLALPFLAYLLAEALHGSGVLAVVVAGLVLGNAGRRSLSPET 259
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281364513 383 RQRTKQIFELLNFLAENFIFSYIGVSMFTFPKHHFDAGFIITAFICAAIGRAVNVYPLSWLlnikRKPKISTNFQHMLFF 462
Cdd:COG0025  260 RLQLLEFWETLEFLLNSLLFVLLGAQLPLILLGALGLGGILLVLLALLVVRPLWVFLSLAL----RGSRLSWRERLFLSW 335
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 281364513 463 AGLRGAMSFALA-----IRNTVSDERQTMLTATSLIVIFTVVIQGGAANFLLNWLKIP 515
Cdd:COG0025  336 GGPRGIVSLALAlslplHGGAGFPGRDLILALAFGVILLTLVLQGLTLPPLARRLGLR 393
a_cpa1 TIGR00831
Na+/H+ antiporter, bacterial form; The Monovalent Cation:Proton Antiporter-1 (CPA1) Family (TC ...
156-530 1.43e-31

Na+/H+ antiporter, bacterial form; The Monovalent Cation:Proton Antiporter-1 (CPA1) Family (TC 2.A.36) The CPA1 family is a large family of proteins derived from Gram-positive and Gram-negative bacteria, blue green bacteria, yeast, plants and animals. Transporters from eukaryotes have been functionally characterized, and all of these catalyze Na+:H+ exchange. Their primary physiological functions may be in (1) cytoplasmic pH regulation, extruding the H+ generated during metabolism, and (2) salt tolerance (in plants), due to Na+ uptake into vacuoles. This model is specific for the bacterial members of this family. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 129911 [Multi-domain]  Cd Length: 525  Bit Score: 129.62  E-value: 1.43e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281364513  156 FDPEVFFNIILPPIIFYAGYSLKKKYFFRNLGAILTFAIVGTTLSAFLIGgFMYGCVKLMPKYLSssftfldsLYFGALI 235
Cdd:TIGR00831  46 LDREIVLFLFLPPLLFEAAMNTDLRELRENFRPIALIAFLLVVVTTVVVG-FSLNWILGIPLALA--------LILGAVL 116
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281364513  236 SPTDPLTILAIFNDLRVDVNLYALVLGESVLNDAVAIVLSGAIQNYGEhysNTGEFETTAflrSLSDFFSIFLLSLMIGA 315
Cdd:TIGR00831 117 SPTDAVAVLGTFKSIRAPKKLSILLEGESLLNDGAALVVFAIAVAVAL---GKGVFDPLN---AALDFAVVCVGGIAAGL 190
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281364513  316 AMGcltALMTKFTRVR-DFPLLESALFVLMSYSTFLLAEATELTGVVAVLFCGICQAHY-TYNNLSEDSRQRTKQIFELL 393
Cdd:TIGR00831 191 AVG---YLAYRLLRAKiDDPLVEIALTILAPFAGFLLAERFHFSGVIAVVAAGLILTNYgRDFSMSPTTRLIALDFWSVI 267
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281364513  394 NFLAENFIFSYIGVSMFTFPKHHF-DAGFIITAFICAAIGRAVNVYP------LSWLLN------IKRKPK-ISTNFQHM 459
Cdd:TIGR00831 268 VFLVNGIIFILIGVQTPGTIFSAWkEILVAPAAVILALFTNAFVIYPvmtyvrFLWTMKpfsnrfLKKKPMeFGTRWKHV 347
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 281364513  460 LFFAGLRGAMSFA--LAIRNTVSD-----ERQTMLTATSLIVIFTVVIQGGAANFLLNWLKIPvgvdDETEQLNNYQV 530
Cdd:TIGR00831 348 VSWAGLRGAIPLAlaLSFPNQLLSgmafpARYELVFLAAGVILFSLLVQGISLPIFVKRKFVS----EHSERELEEII 421
KefB COG0475
Kef-type K+ transport system, membrane component KefB [Inorganic ion transport and metabolism]; ...
169-493 7.26e-07

Kef-type K+ transport system, membrane component KefB [Inorganic ion transport and metabolism];


Pssm-ID: 440243 [Multi-domain]  Cd Length: 384  Bit Score: 52.07  E-value: 7.26e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281364513 169 IIFYAGYSLKKKYFFRNLGAILTFAIVGTTLSAFLIGGFMYGCvklmpkylssSFTFLDSLYFGALISPTDPLTILAIFN 248
Cdd:COG0475   66 LLFLIGLELDLKRLRKMGRRALGIGLLQVLLPFLLGFLLALLL----------GLSLAAALFLGAALAATSTAIVLKVLK 135
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281364513 249 DLRVDVNLYA-LVLGESVLNDAVAIVLSGAIQNYGehysnTGEFETTAFLRSLsdFFSIFLLSLMIGAAMGCLTALMTKF 327
Cdd:COG0475  136 ELGLLKTPLGqLILGVALFDDIAAILLLALVPALA-----GGGSVAGSLLLAL--LKALLFLALLLLVGRYLLRRLFRLV 208
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281364513 328 TRVRDFPLLESALFVLMsystFLLAEATELTGVVAVL---FCGICqahytynnLSEDSRQrtKQIFELLNFLAENFI--- 401
Cdd:COG0475  209 ARTRSRELFLLFALLLV----LLAAALAELLGLSAALgafLAGLV--------LAESEYR--HELEEKIEPFGDLFLplf 274
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281364513 402 FSYIGVSmFTFPKHHFDAGFIITAFICAAIGRAVNVYPLSWLLNIKRKpkistnfQHMLFFAGL--RGAMSFALAI---- 475
Cdd:COG0475  275 FVSVGLS-LDLSALLSNPLLALLLVLAAIVGKLLGAYLAARLFGLSRR-------EALRIGLLLapRGEFALVLASlgls 346
                        330
                 ....*....|....*...
gi 281364513 476 RNTVSDERQTMLTATSLI 493
Cdd:COG0475  347 AGLISPELFAALVLVVLL 364
PRK05326 PRK05326
potassium/proton antiporter;
169-534 1.68e-04

potassium/proton antiporter;


Pssm-ID: 235410 [Multi-domain]  Cd Length: 562  Bit Score: 44.81  E-value: 1.68e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281364513 169 IIFYAGYSLKKKYFFRNLGAILTFAIVGTTLSAFLIGGFMYgcvklmpkYLSSsFTFLDSLYFGALISPTDPltiLAIFN 248
Cdd:PRK05326  70 ILFDGGLRTRWSSFRPALGPALSLATLGVLITAGLTGLFAH--------WLLG-LDWLEGLLLGAIVGSTDA---AAVFS 137
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281364513 249 DLR-VDVNLY----ALVLGESVLNDAVA----IVLSGAIQNygehysntgeFETTAFLRSLSDFFSIFLLSLMIGAAMGC 319
Cdd:PRK05326 138 LLRgKGLNLKervaSTLEIESGSNDPMAvfltITLIELITG----------GETGLSWGFLLLFLQQFGLGALIGLLGGW 207
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281364513 320 LTALMtkftrVRDFPLLESALFVLMSYS----TFLLAEATELTGVVAVLFCGIcqahyTYNNLSEDSRQRTKQIFELLNF 395
Cdd:PRK05326 208 LLVQL-----LNRIALPAEGLYPILVLAgallIFALTAALGGSGFLAVYLAGL-----VLGNRPIRHRHSILRFFDGLAW 277
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281364513 396 LAENFIFSYIGvsMFTFPKHHFDAgfIITAFICAA----IGRAVNVYPLSWLLNIKRKPKIstnfqhMLFFAGLRGAMSF 471
Cdd:PRK05326 278 LAQIGMFLVLG--LLVTPSRLLDI--ALPALLLALflilVARPLAVFLSLLPFRFNLREKL------FISWVGLRGAVPI 347
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 281364513 472 ALAI---RNTVSDErQTMLTATSLIVIFTVVIQGGAANFLLNWLkipvGVDDETEQLNNYQVHSDV 534
Cdd:PRK05326 348 VLATfpmMAGLPNA-QLIFNVVFFVVLVSLLLQGTTLPWAARKL----GVVVPPEARPVSRVELDP 408
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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