BI-1 Bax Inhibitor-1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: BI-1provided by FlyBase
Official Full Name: Bax Inhibitor-1provided by FlyBase
Primary source: FLYBASE:FBgn0035871
Locus tag: Dmel_CG7188
See related: AllianceGenome:FB:FBgn0035871
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG7188; d-BI-1; dBI-1; Dmel\CG7188; dTmbim6
Summary: Predicted to enable calcium channel activity and endoribonuclease inhibitor activity. Involved in several processes, including cellular response to unfolded protein; endoplasmic reticulum calcium ion homeostasis; and negative regulation of RNA splicing. Predicted to be part of protein-containing complex. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including adult head; anterior endoderm anlage; embryonic/larval midgut primordium; gut section; and mesoderm. Orthologous to human TMBIM6 (transmembrane BAX inhibitor motif containing 6). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (8307145..8308941, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (8300245..8302041, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables calcium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables endoribonuclease inhibitor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in calcium ion transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to starvation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to unfolded protein	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to unfolded protein	IDA Inferred from Direct Assay more info	PubMed
involved_in endoplasmic reticulum calcium ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of RNA splicing	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of apoptotic signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of apoptotic signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of autophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of endoplasmic reticulum unfolded protein response	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in membrane	ISM Inferred from Sequence Model more info	PubMed
is_active_in membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in organelle membrane	ISM Inferred from Sequence Model more info	PubMed

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