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Conserved domains on  [gi|24660800|ref|NP_729358|]
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Bax Inhibitor-1, isoform B [Drosophila melanogaster]

Protein Classification

BI-1 domain-containing protein( domain architecture ID 10179631)

BI-1 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BI-1 cd10430
BAX inhibitor (BI)-1; Mammalian members of the BAX inhibitor (BI)-1 like family of small ...
 21-231 1.60e-77

BAX inhibitor (BI)-1; Mammalian members of the BAX inhibitor (BI)-1 like family of small transmembrane proteins have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. Their broad tissue distribution and high degree of conservation suggests an important regulatory role. In plants, BI-1 like proteins play a role in pathogen resistance.


:

Pssm-ID: 198412  Cd Length: 213  Bit Score: 232.50  E-value: 1.60e-77
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24660800  21 DRYEPYVREHLSKVYMVLGSTAAATAMGAMLQMRDFLdLGVLAAVATLVLVLGLHFYKDDGKNYYTRLGMLYAFGFCSGQ 100
Cdd:cd10430   2 NQISPSVQQHLKKVYLTLAVALLAAAVGAYVHMVINI-GGLLTGLLSLGLSLWLAFTPSTGKNEPKRLGLLLGFAFLTGA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24660800 101 TLGPLLGYICSINPAIILSALTGTFVTFISLSLSALLAEQGKYLYLGGMLVSVINTMALLSLFNMVFKSYFVQVTQLYVG 180
Cdd:cd10430  81 SLGPLLDLVIAINPSIIVTAFLGTAVIFACFSLAALLAKRREYLYLGGLLSSALSILLLVSLANIFGGSKFLFQAELYLG 160

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|.
gi 24660800 181 VFVMAAFIVYDTQNIVEKCRNGNRDVVQHALDLFFDVLSMFRRLLIILTQK 231
Cdd:cd10430 161 LLVFCGFVLFDTQMIIEKAENGDRDYIWHALDLFVDFVALFRRLLIILAKK 211
 
Name Accession Description Interval E-value
BI-1 cd10430
BAX inhibitor (BI)-1; Mammalian members of the BAX inhibitor (BI)-1 like family of small ...
 21-231 1.60e-77

BAX inhibitor (BI)-1; Mammalian members of the BAX inhibitor (BI)-1 like family of small transmembrane proteins have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. Their broad tissue distribution and high degree of conservation suggests an important regulatory role. In plants, BI-1 like proteins play a role in pathogen resistance.


Pssm-ID: 198412  Cd Length: 213  Bit Score: 232.50  E-value: 1.60e-77
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24660800  21 DRYEPYVREHLSKVYMVLGSTAAATAMGAMLQMRDFLdLGVLAAVATLVLVLGLHFYKDDGKNYYTRLGMLYAFGFCSGQ 100
Cdd:cd10430   2 NQISPSVQQHLKKVYLTLAVALLAAAVGAYVHMVINI-GGLLTGLLSLGLSLWLAFTPSTGKNEPKRLGLLLGFAFLTGA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24660800 101 TLGPLLGYICSINPAIILSALTGTFVTFISLSLSALLAEQGKYLYLGGMLVSVINTMALLSLFNMVFKSYFVQVTQLYVG 180
Cdd:cd10430  81 SLGPLLDLVIAINPSIIVTAFLGTAVIFACFSLAALLAKRREYLYLGGLLSSALSILLLVSLANIFGGSKFLFQAELYLG 160

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|.
gi 24660800 181 VFVMAAFIVYDTQNIVEKCRNGNRDVVQHALDLFFDVLSMFRRLLIILTQK 231
Cdd:cd10430 161 LLVFCGFVLFDTQMIIEKAENGDRDYIWHALDLFVDFVALFRRLLIILAKK 211
Bax1-I pfam01027
Inhibitor of apoptosis-promoting Bax1; Programmed cell-death involves a set of Bcl-2 family ...
 28-228 5.30e-26

Inhibitor of apoptosis-promoting Bax1; Programmed cell-death involves a set of Bcl-2 family proteins, some of which inhibit apoptosis (Bcl-2 and Bcl-XL) and some of which promote it (Bax and Bak). Human Bax inhibitor, BI-1, is an evolutionarily conserved integral membrane protein containing multiple membrane-spanning segments predominantly localized to intracellular membranes. It has 6-7 membrane-spanning domains. The C termini of the mammalian BI-1 proteins are comprised of basic amino acids resembling some nuclear targeting sequences, but otherwise the predicted proteins lack motifs that suggest a function. As plant BI-1 appears to localize predominantly to the ER, we hypothesized that plant BI-1 could also regulate cell death triggered by ER stress. BI-1 appears to exert its effect through an interaction with calmodulin. The budding yeast member of this family has been found unexpectedly to encode a BH3 domain-containing protein (Ybh3p) that regulates the mitochondrial pathway of apoptosis in a phylogenetically conserved manner. Examination of the crystal structure of a bacterial member of this family shows that these proteins mediate a calcium leak across the membrane that is pH-dependent. Calcium homoeostasis balances passive calcium leak with active calcium uptake. The structure exists in a pore-closed and pore-open conformation, at pHs of 8 and 6 respectively, and the pore can be opened by intracrystalline transition; together these findings suggest that pH controls the conformational transition.


Pssm-ID: 460029  Cd Length: 207  Bit Score: 100.33  E-value: 5.30e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24660800    28 REHLSKVYMVLG--------STAAATAMGAMLQMRDFLDLGVLAAVATLVLVLGLH-FYKDDGKNYYTRLGMLYAFGFCS 98
Cdd:pfam01027   1 RQFLRKVYGLLAlgllltaaVAYLVLSSPALLFPSLHPPLFWVLIIAPLGLLFGALlLARKRKYSSNVALLLLLAFTLLM 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24660800    99 GQTLGPLLGYIcsiNPAIILSALTGTFVTFISLSLSALLAEQgKYLYLGGMLVSVINTMALLSLFNMVFKSYFVQVTQLY 178
Cdd:pfam01027  81 GLTLGPLLLVY---TGAIIATAFLGTAAIFGGLSLYALTTKR-DLSFLGGFLFAGLIGLIVASLVNIFLPSSALSLAISY 156

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 24660800   179 VGVFVMAAFIVYDTQNIVEKCRN-GNRDVVQHALDLFFDVLSMFRRLLIIL 228
Cdd:pfam01027 157 LGVLLFSGFILYDTQRIIKRYGEyGDYDAILAALSLYLDFINLFLSLLRIL 207
YbhL COG0670
Integral membrane protein YbhL, putative Ca2+ regulator, Bax inhibitor (BI-1)/TMBIM family ...
 59-228 5.01e-11

Integral membrane protein YbhL, putative Ca2+ regulator, Bax inhibitor (BI-1)/TMBIM family [Inorganic ion transport and metabolism];


Pssm-ID: 440434  Cd Length: 231  Bit Score: 60.58  E-value: 5.01e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24660800  59 LGVLAAVATLVLVLGLHFyKDDGKNYYTRLGMLYAFGFCSGQTLGPLLG-YICSINPAIILSALTGTFVTFISLSLSALL 137
Cdd:COG0670  60 LFWVLLIAPLGLVFLLSK-LANRANSAAALALLFAYTALMGLTLSPILLvYTGLSGPASIAQAFGGTAATFGGLSLYGYT 138

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24660800 138 AEQ-----GKYLYLGGMLVSVintmalLSLFNMVFKSYFVQVTQLYVGVFVMAAFIVYDTQNIVEKCRNgNRDVVQHALD 212
Cdd:COG0670 139 TKRdlsflGSFLFMGLIGLII------ASLVNIFLQSPALSLAISVAGVLLFSGLTLYDTQRIKHGYET-NKQYIMAALS 211

                       170
                ....*....|....*.
gi 24660800 213 LFFDVLSMFRRLLIIL 228
Cdd:COG0670 212 LYLDFINLFLSLLRLL 227
 
Name Accession Description Interval E-value
BI-1 cd10430
BAX inhibitor (BI)-1; Mammalian members of the BAX inhibitor (BI)-1 like family of small ...
 21-231 1.60e-77

BAX inhibitor (BI)-1; Mammalian members of the BAX inhibitor (BI)-1 like family of small transmembrane proteins have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. Their broad tissue distribution and high degree of conservation suggests an important regulatory role. In plants, BI-1 like proteins play a role in pathogen resistance.


Pssm-ID: 198412  Cd Length: 213  Bit Score: 232.50  E-value: 1.60e-77
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24660800  21 DRYEPYVREHLSKVYMVLGSTAAATAMGAMLQMRDFLdLGVLAAVATLVLVLGLHFYKDDGKNYYTRLGMLYAFGFCSGQ 100
Cdd:cd10430   2 NQISPSVQQHLKKVYLTLAVALLAAAVGAYVHMVINI-GGLLTGLLSLGLSLWLAFTPSTGKNEPKRLGLLLGFAFLTGA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24660800 101 TLGPLLGYICSINPAIILSALTGTFVTFISLSLSALLAEQGKYLYLGGMLVSVINTMALLSLFNMVFKSYFVQVTQLYVG 180
Cdd:cd10430  81 SLGPLLDLVIAINPSIIVTAFLGTAVIFACFSLAALLAKRREYLYLGGLLSSALSILLLVSLANIFGGSKFLFQAELYLG 160

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|.
gi 24660800 181 VFVMAAFIVYDTQNIVEKCRNGNRDVVQHALDLFFDVLSMFRRLLIILTQK 231
Cdd:cd10430 161 LLVFCGFVLFDTQMIIEKAENGDRDYIWHALDLFVDFVALFRRLLIILAKK 211
Bax1-I pfam01027
Inhibitor of apoptosis-promoting Bax1; Programmed cell-death involves a set of Bcl-2 family ...
 28-228 5.30e-26

Inhibitor of apoptosis-promoting Bax1; Programmed cell-death involves a set of Bcl-2 family proteins, some of which inhibit apoptosis (Bcl-2 and Bcl-XL) and some of which promote it (Bax and Bak). Human Bax inhibitor, BI-1, is an evolutionarily conserved integral membrane protein containing multiple membrane-spanning segments predominantly localized to intracellular membranes. It has 6-7 membrane-spanning domains. The C termini of the mammalian BI-1 proteins are comprised of basic amino acids resembling some nuclear targeting sequences, but otherwise the predicted proteins lack motifs that suggest a function. As plant BI-1 appears to localize predominantly to the ER, we hypothesized that plant BI-1 could also regulate cell death triggered by ER stress. BI-1 appears to exert its effect through an interaction with calmodulin. The budding yeast member of this family has been found unexpectedly to encode a BH3 domain-containing protein (Ybh3p) that regulates the mitochondrial pathway of apoptosis in a phylogenetically conserved manner. Examination of the crystal structure of a bacterial member of this family shows that these proteins mediate a calcium leak across the membrane that is pH-dependent. Calcium homoeostasis balances passive calcium leak with active calcium uptake. The structure exists in a pore-closed and pore-open conformation, at pHs of 8 and 6 respectively, and the pore can be opened by intracrystalline transition; together these findings suggest that pH controls the conformational transition.


Pssm-ID: 460029  Cd Length: 207  Bit Score: 100.33  E-value: 5.30e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24660800    28 REHLSKVYMVLG--------STAAATAMGAMLQMRDFLDLGVLAAVATLVLVLGLH-FYKDDGKNYYTRLGMLYAFGFCS 98
Cdd:pfam01027   1 RQFLRKVYGLLAlgllltaaVAYLVLSSPALLFPSLHPPLFWVLIIAPLGLLFGALlLARKRKYSSNVALLLLLAFTLLM 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24660800    99 GQTLGPLLGYIcsiNPAIILSALTGTFVTFISLSLSALLAEQgKYLYLGGMLVSVINTMALLSLFNMVFKSYFVQVTQLY 178
Cdd:pfam01027  81 GLTLGPLLLVY---TGAIIATAFLGTAAIFGGLSLYALTTKR-DLSFLGGFLFAGLIGLIVASLVNIFLPSSALSLAISY 156

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 24660800   179 VGVFVMAAFIVYDTQNIVEKCRN-GNRDVVQHALDLFFDVLSMFRRLLIIL 228
Cdd:pfam01027 157 LGVLLFSGFILYDTQRIIKRYGEyGDYDAILAALSLYLDFINLFLSLLRIL 207
BI-1-like cd06181
BAX inhibitor (BI)-1/YccA-like protein family; Mammalian members of the BAX inhibitor (BI)-1 ...
 26-228 1.64e-19

BAX inhibitor (BI)-1/YccA-like protein family; Mammalian members of the BAX inhibitor (BI)-1 like family of small transmembrane proteins have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. Their broad tissue distribution and high degree of conservation suggests an important regulatory role. This superfamily also contains the lifeguard(LFG)-like proteins and other subfamilies which appear to be related by common descent and also function as inhibitors of apoptosis. In plants, BI-1 like proteins play a role in pathogen resistance. A prokaryotic member, Escherichia coli YccA, has been shown to interact with ATP-dependent protease FtsH, which degrades abnormal membrane proteins as part of a quality control mechanism to keep the integrity of biological membranes.


Pssm-ID: 198409  Cd Length: 202  Bit Score: 83.23  E-value: 1.64e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24660800  26 YVREHLSKVYMVLGSTAAATAMGAMLQMR-DFLDLGVLAAVATLVLVLGLHFYKDDGKNYYT-RLGMLYAFGFCSGQTLG 103
Cdd:cd06181   1 STKDFLRKVYMILALQLLLTAATATAFTVcDPGWYWSPALMGLLTSMLALMATAAMIRAKMPvNLILLFGFTGLMGYVVG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24660800 104 PLLGYIcsiNPAIILSALTGTFVTFISLSLSALLAEQgKYLYLGGMLVSVINTMALLSLFNMVFKSYFVQVTQLYVGVFV 183
Cdd:cd06181  81 PLLFFY---GPTILLRALGGTALVFFGLTVYALQARK-DFLFLGGPLMAGLGFLLLSFLLNTFFYSPWLHLVAAAVGLVL 156

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 24660800 184 MAAFIVYDTQNIVEKCRNGNRDVVQHALDLFFDVLSMFRRLLIIL 228
Cdd:cd06181 157 FCGFLLYDTQLIIHKAEVGPEDYINACISLYLDIINIFIRLLTIL 201
YbhL COG0670
Integral membrane protein YbhL, putative Ca2+ regulator, Bax inhibitor (BI-1)/TMBIM family ...
 59-228 5.01e-11

Integral membrane protein YbhL, putative Ca2+ regulator, Bax inhibitor (BI-1)/TMBIM family [Inorganic ion transport and metabolism];


Pssm-ID: 440434  Cd Length: 231  Bit Score: 60.58  E-value: 5.01e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24660800  59 LGVLAAVATLVLVLGLHFyKDDGKNYYTRLGMLYAFGFCSGQTLGPLLG-YICSINPAIILSALTGTFVTFISLSLSALL 137
Cdd:COG0670  60 LFWVLLIAPLGLVFLLSK-LANRANSAAALALLFAYTALMGLTLSPILLvYTGLSGPASIAQAFGGTAATFGGLSLYGYT 138

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24660800 138 AEQ-----GKYLYLGGMLVSVintmalLSLFNMVFKSYFVQVTQLYVGVFVMAAFIVYDTQNIVEKCRNgNRDVVQHALD 212
Cdd:COG0670 139 TKRdlsflGSFLFMGLIGLII------ASLVNIFLQSPALSLAISVAGVLLFSGLTLYDTQRIKHGYET-NKQYIMAALS 211

                       170
                ....*....|....*.
gi 24660800 213 LFFDVLSMFRRLLIIL 228
Cdd:COG0670 212 LYLDFINLFLSLLRLL 227
BI-1-like_bacterial cd10432
Bacterial BAX inhibitor (BI)-1/YccA-like proteins; This family is comprised of bacterial ...
 59-228 3.34e-10

Bacterial BAX inhibitor (BI)-1/YccA-like proteins; This family is comprised of bacterial relatives of the mammalian members of the BAX inhibitor (BI)-1 like family of small transmembrane proteins, which have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. In plants, BI-1 like proteins play a role in pathogen resistance. A characterized prokaryotic member, Escherichia coli YccA, has been shown to interact with ATP-dependent protease FtsH, which degrades abnormal membrane proteins as part of a quality control mechanism to keep the integrity of biological membranes.


Pssm-ID: 198414  Cd Length: 211  Bit Score: 57.96  E-value: 3.34e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24660800  59 LGVLAAVATLVLVLGLHFYKDDgKNYYTRLGMLYAFGFCSGQTLGPLLGYICSinpAIILSALTGTFVTFISLSLSALLA 138
Cdd:cd10432  41 LMWVLLIAELALVFGLSFRINK-MSVATALPLFFAFAALTGLTLSPILLVYTG---ASIAQAFFTTAATFGGLSLYGYTT 116

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24660800 139 eQGKYLYLGGMLVSVINTMALLSLFNMVFKSYFVQVTQLYVGVFVMAAFIVYDTQNIVEKCRNGNRDVVQH-----ALDL 213
Cdd:cd10432 117 -KKDLSFLGSFLFMGLIGLIIASLVNIFLQSSALQFAISAIGVLIFSGLIAYDTQRIKRMYEAGGGESGYKdaimgALSL 195

                       170
                ....*....|....*
gi 24660800 214 FFDVLSMFRRLLIIL 228
Cdd:cd10432 196 YLDFINLFLFLLRLF 210
YccA_like cd10433
YccA-like proteins; A prokaryotic member of the BAX inhibitor (BI)-1 like family of small ...
 31-228 4.62e-09

YccA-like proteins; A prokaryotic member of the BAX inhibitor (BI)-1 like family of small transmembrane proteins, Escherichia coli YccA, has been shown to interact with ATP-dependent protease FtsH, which degrades abnormal membrane proteins as part of a quality control mechanism to keep the integrity of biological membranes.


Pssm-ID: 198415  Cd Length: 205  Bit Score: 54.51  E-value: 4.62e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24660800  31 LSKVYMVLGSTAAATAMGAMLQMrdFLDLGVLAAVATLVLVLGLHFYKDDGKNYYTRLGMLYAFGFCSGQTLGPLLGYIC 110
Cdd:cd10433   7 LRNTYMLLSMTLAFSALGAGVSM--AGGSPIMGLLLTLVGAYGLLFLIEKTRNSAWGIVLVFAFTGFMGYTLGPILNMYL 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24660800 111 SIN--PAIILSALTGTFVTFISLSLSALLAEQgKYLYLGGMLVSVINTMALLSLFNMVFKSYFVQVTQLYVGVFVMAAFI 188
Cdd:cd10433  85 ALPngGQIIMTALGGTAAIFFGLSAYALTTKK-DFSFLGGFLFVGAIVLLLAAVANIFLQIPALSLAISAAFVLFSSGFI 163

                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 24660800 189 VYDTQNIVekcRNGNRDVVQHALDLFFDVLSMFRRLLIIL 228
Cdd:cd10433 164 LYDTSRII---HGGETNYIMATVSLYVSIYNLFVSLLNLL 200
GHITM cd10431
Growth-hormone inducible transmembrane protein; GHITM appears to be ubiquitiously expressed in ...
 26-228 1.84e-08

Growth-hormone inducible transmembrane protein; GHITM appears to be ubiquitiously expressed in mammalian cells and expression has also been observed in various cancer cell lines. A cytoprotective function has been suggested. It is closely related to the BAX inhibitor (BI)-1 like family of small transmembrane proteins, which have been shown to have an antiapoptotic effect.


Pssm-ID: 198413  Cd Length: 264  Bit Score: 53.54  E-value: 1.84e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24660800  26 YVREHLSKVYMVLGSTAAATAM----------GAMLQMRD---FLDLGVLAAVATLVLVLGLHFYKDDGKNYYTRLgmly 92
Cdd:cd10431  39 YVRDRIHSTYMYFGGSLGLTALaavalsrspaLMRLMAAGpwlAIGATLAAMIGSGMLVRSYTYPENPGAKHLAWL---- 114

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24660800  93 afGFCSgqTLGPLLGYICSINPAIILSALTGTFVTFISLSLSALLAEQGKYLYLGGMLVSVINTMALLSLFNMVF--KSY 170
Cdd:cd10431 115 --GHSG--VQGAVLAPLCFLGGPLLIRAALYTAGIVGGLSTVAACAPSEKFLYMGGPLAIGLGVVFASSLGSMFLppTTA 190

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24660800 171 FVQVTQ---LYVGVFVMAAFIVYDTQNIVEKCRNG------NRDVVQHALDLFFDVLSMFRRLLIIL 228
Cdd:cd10431 191 LGAGLYsvsLYGGLVLFGGFLLYDTQKIIKRAETHplygvrKYDPINASMSIYMDTINIFIRLVTIL 257
GAAP_like cd10429
Golgi antiapoptotic protein; GAAP (or transmembrane BAX inhibitor motif containing 4) is a ...
 61-228 3.92e-07

Golgi antiapoptotic protein; GAAP (or transmembrane BAX inhibitor motif containing 4) is a regulator of apoptosis that is related to the BAX inhibitor (BI)-1 like family of small transmembrane proteins, which have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. Human GAAP has been linked to the modulation of intracellular fluxes of Ca(2+), by suppressing influx from the extracellular medium and reducing release from intracellular stores. A viral homolog (vaccinia virus vGAAP) acts similar to its human counterpart in inhibiting apoptosis.


Pssm-ID: 198411  Cd Length: 233  Bit Score: 49.14  E-value: 3.92e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24660800  61 VLAAVATLVLVLGLHFYKddgKNYYTRLGMLYAFGFCSGQTLGpllgYICSI-NPAIILSALTGTFVTFISLSLSALlae 139
Cdd:cd10429  70 LISLIGSLILLIALYWKR---HSHPVNLILLSLFTLCEAYTVG----LVVSFyDGKIVLQALILTLGVFVGLTAYTF--- 139

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24660800 140 QGKY-----LYLGGMLVSVINTMALLSLFNmvFKSYFVQVTQLYVGVFVMAAFIVYDTQNIVEKCRngNRDVVQHALDLF 214
Cdd:cd10429 140 QTKRdfssfGALLFILLWALILLALIFQFF--PYSPTFELVYAGLGALLFSGYIVYDTQLIMKRLS--PDEYILAAISLY 215

                       170
                ....*....|....
gi 24660800 215 FDVLSMFRRLLIIL 228
Cdd:cd10429 216 LDIINLFLSILRIL 229
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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