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    Atp2b4 ATPase plasma membrane Ca2+ transporting 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29600, updated on 27-Nov-2024

    Summary

    Symbol
    Atp2b4provided by RGD
    Full Name
    ATPase plasma membrane Ca2+ transporting 4provided by RGD
    Primary source
    RGD:621305
    See related
    EnsemblRapid:ENSRNOG00000003031 AllianceGenome:RGD:621305
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    PMCA4
    Summary
    Enables P-type calcium transporter activity; PDZ domain binding activity; and protein kinase binding activity. Involved in several processes, including calcium ion transport; hippocampus development; and negative regulation of calcineurin-NFAT signaling cascade. Located in basolateral plasma membrane and sperm principal piece. Is active in glutamatergic synapse and presynaptic active zone membrane. Biomarker of dystonia. Orthologous to human ATP2B4 (ATPase plasma membrane Ca2+ transporting 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Uterus (RPKM 146.2), Lung (RPKM 129.1) and 8 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Atp2b4 in Genome Data Viewer
    Location:
    13q13
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (47708157..47807389, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (45156137..45255292, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (50091644..50153808)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108352533 Neighboring gene NADH:ubiquinone oxidoreductase subunit B10, pseudogene 1 Neighboring gene uncharacterized LOC120096250 Neighboring gene lymphocyte transmembrane adaptor 1 Neighboring gene uncharacterized LOC134481499 Neighboring gene uncharacterized LOC134481498 Neighboring gene uncharacterized LOC102557118 Neighboring gene opticin Neighboring gene proline and arginine rich end leucine rich repeat protein

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables P-type calcium transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables P-type calcium transporter activity IC
    Inferred by Curator
    more info
    PubMed 
    enables P-type calcium transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables P-type calcium transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables P-type calcium transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables PDZ domain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables calcium ion transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables calmodulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nitric-oxide synthase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables nitric-oxide synthase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein phosphatase 2B binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables scaffold protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables sodium channel regulator activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in calcium ion export IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in calcium ion export ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in calcium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in calcium ion transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in calcium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in calcium ion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to acetylcholine ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to acetylcholine ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to epinephrine stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in flagellated sperm motility ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in flagellated sperm motility ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in hippocampus development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in intracellular calcium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intracellular calcium ion homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of arginine catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of blood vessel endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of calcineurin-NFAT signaling cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of calcineurin-NFAT signaling cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cardiac muscle hypertrophy in response to stress ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cellular response to vascular endothelial growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of citrulline biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of nitric oxide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of nitric-oxide synthase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of the force of heart contraction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neural retina development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_negative_effect nitric oxide-cGMP-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell cycle G1/S phase transition ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cytosolic calcium ion concentration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to hydrostatic pressure ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in spermatogenesis IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in urinary bladder smooth muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in urinary bladder smooth muscle contraction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in T-tubule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in Z disc ISO
    Inferred from Sequence Orthology
    more info
     
    located_in basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse EXP
    Inferred from Experiment
    more info
    PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane raft ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in presynaptic active zone membrane EXP
    Inferred from Experiment
    more info
    PubMed 
    is_active_in presynaptic active zone membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in sarcolemma ISO
    Inferred from Sequence Orthology
    more info
     
    located_in sperm flagellum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in sperm principal piece IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    plasma membrane calcium-transporting ATPase 4
    Names
    ATPase, Ca++ transporting, plasma membrane 4
    plasma membrane Ca2+-ATPases 4
    plasma membrane calcium ATPase
    plasma membrane calcium pump
    NP_001005871.1
    XP_008767668.1
    XP_038946568.1
    XP_038946569.1
    XP_038946570.1
    XP_038946571.1
    XP_038946572.1
    XP_038946574.1
    XP_063128279.1
    XP_063128280.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001005871.1NP_001005871.1  plasma membrane calcium-transporting ATPase 4

      See identical proteins and their annotated locations for NP_001005871.1

      Status: PROVISIONAL

      Source sequence(s)
      U15408
      UniProtKB/TrEMBL
      A6IC90
      Related
      ENSRNOP00000004078.6, ENSRNOT00000004078.8
      Conserved Domains (2) summary
      TIGR01517
      Location:161052
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam12424
      Location:10891126
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      47708157..47807389 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039090642.2XP_038946570.1  plasma membrane calcium-transporting ATPase 4 isoform X2

      UniProtKB/TrEMBL
      A6IC89
      Related
      ENSRNOP00000080557.1, ENSRNOT00000112237.2
      Conserved Domains (2) summary
      TIGR01517
      Location:161040
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam12424
      Location:10771122
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
    2. XM_039090644.2XP_038946572.1  plasma membrane calcium-transporting ATPase 4 isoform X4

      UniProtKB/TrEMBL
      A6IC90
      Conserved Domains (2) summary
      TIGR01517
      Location:161040
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam12424
      Location:10771114
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
    3. XM_039090640.2XP_038946568.1  plasma membrane calcium-transporting ATPase 4 isoform X1

      UniProtKB/Swiss-Prot
      Q63127, Q63445, Q64542, Q64543, Q64544, Q64545
      UniProtKB/TrEMBL
      A6IC89
      Related
      ENSRNOP00000039880.5, ENSRNOT00000046273.6
      Conserved Domains (2) summary
      TIGR01517
      Location:161052
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam12424
      Location:10891134
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
    4. XM_039090646.2XP_038946574.1  plasma membrane calcium-transporting ATPase 4 isoform X6

      UniProtKB/TrEMBL
      A6IC89
      Conserved Domains (2) summary
      TIGR01517
      Location:161052
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam12424
      Location:10891172
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
    5. XM_039090643.2XP_038946571.1  plasma membrane calcium-transporting ATPase 4 isoform X3

      UniProtKB/TrEMBL
      A6IC90
      Conserved Domains (2) summary
      TIGR01517
      Location:161052
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam12424
      Location:10891126
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
    6. XM_008769446.4XP_008767668.1  plasma membrane calcium-transporting ATPase 4 isoform X1

      See identical proteins and their annotated locations for XP_008767668.1

      UniProtKB/Swiss-Prot
      Q63127, Q63445, Q64542, Q64543, Q64544, Q64545
      UniProtKB/TrEMBL
      A6IC89
      Conserved Domains (2) summary
      TIGR01517
      Location:161052
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam12424
      Location:10891134
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
    7. XM_063272209.1XP_063128279.1  plasma membrane calcium-transporting ATPase 4 isoform X3

    8. XM_039090641.2XP_038946569.1  plasma membrane calcium-transporting ATPase 4 isoform X1

      UniProtKB/Swiss-Prot
      Q63127, Q63445, Q64542, Q64543, Q64544, Q64545
      UniProtKB/TrEMBL
      A6IC89
      Conserved Domains (2) summary
      TIGR01517
      Location:161052
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam12424
      Location:10891134
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
    9. XM_063272210.1XP_063128280.1  plasma membrane calcium-transporting ATPase 4 isoform X5