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Conserved domains on  [gi|54312088|ref|NP_001005871|]
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plasma membrane calcium-transporting ATPase 4 [Rattus norvegicus]

Protein Classification

plasma membrane calcium-transporting ATPase( domain architecture ID 13522140)

plasma membrane calcium-transporting ATPase functions to export Ca(2+) from cells and plays a role in regulating Ca(2+) signals following stimulus induction and in preventing calcium toxicity

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
ATPase-IIB_Ca super family cl36924
plasma-membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase ...
16-1052 0e+00

plasma-membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase responsible for translocating calcium ions across the plasma membrane of eukaryotes, out of the cell. In some organisms, this type of pump may also be found in vacuolar membranes. In humans and mice, at least, there are multiple isoforms of the PMCA pump with overlapping but not redundant functions. Accordingly, there are no human diseases linked to PMCA defects, although alterations of PMCA function do elicit physiological effects. The calcium P-type ATPases have been characterized as Type IIB based on a phylogenetic analysis which distinguishes this group from the Type IIA SERCA calcium pump. A separate analysis divides Type IIA into sub-types (SERCA and PMR1) which are represented by two corresponding models (TIGR01116 and TIGR01522). This model is well separated from those.


The actual alignment was detected with superfamily member TIGR01517:

Pssm-ID: 273668 [Multi-domain]  Cd Length: 956  Bit Score: 1295.13  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088     16 ESYEGEFGCTLMDLRKLMELRAADAV---TQISAHYGSVQEICARLKTSPVEGLSGNPADLEKRRLVFGKNMIPPKKPKT 92
Cdd:TIGR01517    7 RTSIRDNFTDGFDVGVSILTDLTDIFkkaMPLYEKLGGAEGIATKLKTDLNEGVRLSSSTLERREKVYGKNELPEKPPKS 86
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088     93 FLELVWEALQDVTLIILEIAAIISLVLSFYRPpggeneicghivSNPEEDEEGETGWIEGAAILASVIIVVFVTAFNDWS 172
Cdd:TIGR01517   87 FLQIVWAALSDQTLILLSVAAVVSLVLGLYVP------------SVGEDKADTETGWIEGVAILVSVILVVLVTAVNDYK 154
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    173 KEKQFRGLQsRIELEQKFSIIRNGQLIQLPVAEIVVGDIAQVKYGDLLPADGILIQGNDLKIDESSLTGESDHVKKTLDK 252
Cdd:TIGR01517  155 KELQFRQLN-REKSAQKIAVIRGGQEQQISIHDIVVGDIVSLSTGDVVPADGVFISGLSLEIDESSITGESDPIKKGPVQ 233
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    253 DPMLLSGTHVMEGSGRMVVTAVGINSQTGIIFTLLGaneeeddekkkkgkkqgvsenrnkaktqdgvaleiqplnsQEGL 332
Cdd:TIGR01517  234 DPFLLSGTVVNEGSGRMLVTAVGVNSFGGKLMMELR----------------------------------------QAGE 273
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    333 DSEekekkaskgpkkeksVLQGKLTRLAVQIGKAGLIMSILTVLILILYFVVDNFVIQRRawlPECTPVYIQYFVKFFII 412
Cdd:TIGR01517  274 EET---------------PLQEKLSELAGLIGKFGMGSAVLLFLVLSLRYVFRIIRGDGR---FEDTEEDAQTFLDHFII 335
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    413 GVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTMNRMTVVQAYIGGTHYRqipK 492
Cdd:TIGR01517  336 AVTIVVVAVPEGLPLAVTIALAYSMKKMMKDNNLVRHLAACETMGSATAICSDKTGTLTQNVMSVVQGYIGEQRFN---V 412
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    493 PDDLPPNVLDLIVNSICINSAYTSKILPPEKE-GGLPRQVGNKTECGLLGFVTDLKQDYQAVRSEMPEEKLFKVYTFNSV 571
Cdd:TIGR01517  413 RDEIVLRNLPAAVRNILVEGISLNSSSEEVVDrGGKRAFIGSKTECALLDFGLLLLLQSRDVQEVRAEEKVVKIYPFNSE 492
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    572 RKSMSTVIRKPEGGFRVFSKGASEIMLRKCDRILNKEGGIVPFkTKDRDNMVRNVIEPMASEGLRTIGIAYRDFDGEE-P 650
Cdd:TIGR01517  493 RKFMSVVVKHSGGKYREFRKGASEIVLKPCRKRLDSNGEATPI-SEDDKDRCADVIEPLASDALRTICLAYRDFAPEEfP 571
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    651 SWENENeifTGLVCIAVVGIEDPVRPEVPDAINKCKRAGITVRMVTGDNVNTARAIATKCGILTPGDdfLCLEGKEFNRL 730
Cdd:TIGR01517  572 RKDYPN---KGLTLIGVVGIKDPLRPGVREAVQECQRAGITVRMVTGDNIDTAKAIARNCGILTFGG--LAMEGKEFRSL 646
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    731 IRNEkgeveqekLDKVWPRLRVLARSSPTDKHTLVKGIIDsnigeQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVA 810
Cdd:TIGR01517  647 VYEE--------MDPILPKLRVLARSSPLDKQLLVLMLKD-----MGEVVAVTGDGTNDAPALKLADVGFSMGISGTEVA 713
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    811 KEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFSGACIT--QDSPLKAVQMLWVNLIMDTFASL 888
Cdd:TIGR01517  714 KEASDIILLDDNFASIVRAVKWGRNVYDNIRKFLQFQLTVNVVAVILTFVGSCISssHTSPLTAVQLLWVNLIMDTLAAL 793
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    889 ALATEPPTDSLLRRRPYGRNKPLISRTMMKNILGHAVYQLGIVFLLVFAGDKLFDIDSGRKAPlNSPPSQHYTIVFNTFV 968
Cdd:TIGR01517  794 ALATEPPTEALLDRKPIGRNAPLISRSMWKNILGQAGYQLVVTFILLFAGGSIFDVSGPDEIT-SHQQGELNTIVFNTFV 872
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    969 LMQLFNEINSRKIHGEKNVFAGVYRNIIFCSVVLGTFFCQILIVEVGGKPFSCTNLTMEQWMWCLFIGIGELLWGQVISA 1048
Cdd:TIGR01517  873 LLQLFNEINARKLYEGMNVFEGLFKNRIFVTIMGFTFGFQVIIVEFGGSFFSTVSLSIEQWIGCVLLGMLSLIFGVLLRL 952

                   ....
gi 54312088   1049 IPTK 1052
Cdd:TIGR01517  953 IPVE 956
ATP_Ca_trans_C pfam12424
Plasma membrane calcium transporter ATPase C terminal; This domain family is found in ...
1089-1126 8.13e-11

Plasma membrane calcium transporter ATPase C terminal; This domain family is found in eukaryotes, and is approximately 60 amino acids in length. The family is found in association with pfam00689, pfam00122, pfam00702, pfam00690. There is a conserved QTQ sequence motif. This family is the C terminal of a calcium transporting ATPase located in the plasma membrane.


:

Pssm-ID: 463575  Cd Length: 47  Bit Score: 58.19  E-value: 8.13e-11
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 54312088   1089 GQILWVRGLNRIQTQIEVINKFQTGAsFKGVLRRQNLS 1126
Cdd:pfam12424    1 GQILWFRGLNRIQTQIRVVKAFQSSL-REGIQKPYLRN 37
 
Name Accession Description Interval E-value
ATPase-IIB_Ca TIGR01517
plasma-membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase ...
16-1052 0e+00

plasma-membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase responsible for translocating calcium ions across the plasma membrane of eukaryotes, out of the cell. In some organisms, this type of pump may also be found in vacuolar membranes. In humans and mice, at least, there are multiple isoforms of the PMCA pump with overlapping but not redundant functions. Accordingly, there are no human diseases linked to PMCA defects, although alterations of PMCA function do elicit physiological effects. The calcium P-type ATPases have been characterized as Type IIB based on a phylogenetic analysis which distinguishes this group from the Type IIA SERCA calcium pump. A separate analysis divides Type IIA into sub-types (SERCA and PMR1) which are represented by two corresponding models (TIGR01116 and TIGR01522). This model is well separated from those.


Pssm-ID: 273668 [Multi-domain]  Cd Length: 956  Bit Score: 1295.13  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088     16 ESYEGEFGCTLMDLRKLMELRAADAV---TQISAHYGSVQEICARLKTSPVEGLSGNPADLEKRRLVFGKNMIPPKKPKT 92
Cdd:TIGR01517    7 RTSIRDNFTDGFDVGVSILTDLTDIFkkaMPLYEKLGGAEGIATKLKTDLNEGVRLSSSTLERREKVYGKNELPEKPPKS 86
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088     93 FLELVWEALQDVTLIILEIAAIISLVLSFYRPpggeneicghivSNPEEDEEGETGWIEGAAILASVIIVVFVTAFNDWS 172
Cdd:TIGR01517   87 FLQIVWAALSDQTLILLSVAAVVSLVLGLYVP------------SVGEDKADTETGWIEGVAILVSVILVVLVTAVNDYK 154
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    173 KEKQFRGLQsRIELEQKFSIIRNGQLIQLPVAEIVVGDIAQVKYGDLLPADGILIQGNDLKIDESSLTGESDHVKKTLDK 252
Cdd:TIGR01517  155 KELQFRQLN-REKSAQKIAVIRGGQEQQISIHDIVVGDIVSLSTGDVVPADGVFISGLSLEIDESSITGESDPIKKGPVQ 233
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    253 DPMLLSGTHVMEGSGRMVVTAVGINSQTGIIFTLLGaneeeddekkkkgkkqgvsenrnkaktqdgvaleiqplnsQEGL 332
Cdd:TIGR01517  234 DPFLLSGTVVNEGSGRMLVTAVGVNSFGGKLMMELR----------------------------------------QAGE 273
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    333 DSEekekkaskgpkkeksVLQGKLTRLAVQIGKAGLIMSILTVLILILYFVVDNFVIQRRawlPECTPVYIQYFVKFFII 412
Cdd:TIGR01517  274 EET---------------PLQEKLSELAGLIGKFGMGSAVLLFLVLSLRYVFRIIRGDGR---FEDTEEDAQTFLDHFII 335
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    413 GVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTMNRMTVVQAYIGGTHYRqipK 492
Cdd:TIGR01517  336 AVTIVVVAVPEGLPLAVTIALAYSMKKMMKDNNLVRHLAACETMGSATAICSDKTGTLTQNVMSVVQGYIGEQRFN---V 412
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    493 PDDLPPNVLDLIVNSICINSAYTSKILPPEKE-GGLPRQVGNKTECGLLGFVTDLKQDYQAVRSEMPEEKLFKVYTFNSV 571
Cdd:TIGR01517  413 RDEIVLRNLPAAVRNILVEGISLNSSSEEVVDrGGKRAFIGSKTECALLDFGLLLLLQSRDVQEVRAEEKVVKIYPFNSE 492
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    572 RKSMSTVIRKPEGGFRVFSKGASEIMLRKCDRILNKEGGIVPFkTKDRDNMVRNVIEPMASEGLRTIGIAYRDFDGEE-P 650
Cdd:TIGR01517  493 RKFMSVVVKHSGGKYREFRKGASEIVLKPCRKRLDSNGEATPI-SEDDKDRCADVIEPLASDALRTICLAYRDFAPEEfP 571
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    651 SWENENeifTGLVCIAVVGIEDPVRPEVPDAINKCKRAGITVRMVTGDNVNTARAIATKCGILTPGDdfLCLEGKEFNRL 730
Cdd:TIGR01517  572 RKDYPN---KGLTLIGVVGIKDPLRPGVREAVQECQRAGITVRMVTGDNIDTAKAIARNCGILTFGG--LAMEGKEFRSL 646
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    731 IRNEkgeveqekLDKVWPRLRVLARSSPTDKHTLVKGIIDsnigeQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVA 810
Cdd:TIGR01517  647 VYEE--------MDPILPKLRVLARSSPLDKQLLVLMLKD-----MGEVVAVTGDGTNDAPALKLADVGFSMGISGTEVA 713
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    811 KEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFSGACIT--QDSPLKAVQMLWVNLIMDTFASL 888
Cdd:TIGR01517  714 KEASDIILLDDNFASIVRAVKWGRNVYDNIRKFLQFQLTVNVVAVILTFVGSCISssHTSPLTAVQLLWVNLIMDTLAAL 793
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    889 ALATEPPTDSLLRRRPYGRNKPLISRTMMKNILGHAVYQLGIVFLLVFAGDKLFDIDSGRKAPlNSPPSQHYTIVFNTFV 968
Cdd:TIGR01517  794 ALATEPPTEALLDRKPIGRNAPLISRSMWKNILGQAGYQLVVTFILLFAGGSIFDVSGPDEIT-SHQQGELNTIVFNTFV 872
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    969 LMQLFNEINSRKIHGEKNVFAGVYRNIIFCSVVLGTFFCQILIVEVGGKPFSCTNLTMEQWMWCLFIGIGELLWGQVISA 1048
Cdd:TIGR01517  873 LLQLFNEINARKLYEGMNVFEGLFKNRIFVTIMGFTFGFQVIIVEFGGSFFSTVSLSIEQWIGCVLLGMLSLIFGVLLRL 952

                   ....
gi 54312088   1049 IPTK 1052
Cdd:TIGR01517  953 IPVE 956
P-type_ATPase_Ca_PMCA-like cd02081
animal plasma membrane Ca2(+)-ATPases (PMCA), similar to human ATP2B1-4/PMCA1-4, and related ...
73-916 0e+00

animal plasma membrane Ca2(+)-ATPases (PMCA), similar to human ATP2B1-4/PMCA1-4, and related Ca2(+)-ATPases including Saccharomyces cerevisiae vacuolar PMC1; Animal PMCAs function to export Ca(2+) from cells and play a role in regulating Ca(2+) signals following stimulus induction and in preventing calcium toxicity. Many PMCA pump variants exist due to alternative splicing of transcripts. PMCAs are regulated by the binding of calmodulin or by kinase-mediated phosphorylation. Saccharomyces cerevisiae vacuolar transporter Pmc1p facilitates the accumulation of Ca2+ into vacuoles. Pmc1p is not regulated by direct calmodulin binding but responds to the calmodulin/calcineurin-signaling pathway and is controlled by the transcription factor complex Tcn1p/Crz1p. Similarly, the expression of the gene for Dictyostelium discoideum Ca(2+)-ATPase PAT1, patA, is under the control of a calcineurin-dependent transcription factor. Plant vacuolar Ca(2+)-ATPases, are regulated by direct-calmodulin binding. Plant Ca(2+)-ATPases are present at various cellular locations including the plasma membrane, endoplasmic reticulum, chloroplast and vacuole. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319776 [Multi-domain]  Cd Length: 721  Bit Score: 1280.61  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088   73 LEKRRLVFGKNMIPPKKPKTFLELVWEALQDVTLIILEIAAIISLVLSFYRPPGgeneicghivsnpeeDEEGETGWIEG 152
Cdd:cd02081    1 LEHRREVYGKNEIPPKPPKSFLQLVWEALQDPTLIILLIAAIVSLGLGFYTPFG---------------EGEGKTGWIEG 65
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  153 AAILASVIIVVFVTAFNDWSKEKQFRGLQSRIElEQKFSIIRNGQLIQLPVAEIVVGDIAQVKYGDLLPADGILIQGNDL 232
Cdd:cd02081   66 VAILVAVILVVLVTAGNDYQKEKQFRKLNSKKE-DQKVTVIRDGEVIQISVFDIVVGDIVQLKYGDLIPADGLLIEGNDL 144
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  233 KIDESSLTGESDHVKKTLD---KDPMLLSGTHVMEGSGRMVVTAVGINSQTGIIFTLLGANeeeddekkkkgkkqgvsen 309
Cdd:cd02081  145 KIDESSLTGESDPIKKTPDnqiPDPFLLSGTKVLEGSGKMLVTAVGVNSQTGKIMTLLRAE------------------- 205
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  310 rnkaktqdgvaleiqplnsqegldseekekkaskgpKKEKSVLQGKLTRLAVQIGKAGLIMSILTVLILILYFVVDNFVI 389
Cdd:cd02081  206 ------------------------------------NEEKTPLQEKLTKLAVQIGKVGLIVAALTFIVLIIRFIIDGFVN 249
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  390 QRRawlpECTPVYIQYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGT 469
Cdd:cd02081  250 DGK----SFSAEDLQEFVNFFIIAVTIIVVAVPEGLPLAVTLSLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGT 325
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  470 LTMNRMTVVQAYIGgthyrqipkpddlppnvldlivnsicinsaytskilppekegglprqvgNKTECGLLGFVTDLKQD 549
Cdd:cd02081  326 LTQNRMTVVQGYIG-------------------------------------------------NKTECALLGFVLELGGD 356
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  550 YQaVRSEMPEEKLFKVYTFNSVRKSMSTVIRKPEGGFRVFSKGASEIMLRKCDRILNKEGgIVPFKTKDRDNMVRNVIEP 629
Cdd:cd02081  357 YR-YREKRPEEKVLKVYPFNSARKRMSTVVRLKDGGYRLYVKGASEIVLKKCSYILNSDG-EVVFLTSEKKEEIKRVIEP 434
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  630 MASEGLRTIGIAYRDFDGEEP-----SWENENEIFTGLVCIAVVGIEDPVRPEVPDAINKCKRAGITVRMVTGDNVNTAR 704
Cdd:cd02081  435 MASDSLRTIGLAYRDFSPDEEptaerDWDDEEDIESDLTFIGIVGIKDPLRPEVPEAVAKCQRAGITVRMVTGDNINTAR 514
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  705 AIATKCGILTPGDDFLCLEGKEFNRLIRNEKGEVEQEKLDKVWPRLRVLARSSPTDKHTLVKGIIDSnigeqRQVVAVTG 784
Cdd:cd02081  515 AIARECGILTEGEDGLVLEGKEFRELIDEEVGEVCQEKFDKIWPKLRVLARSSPEDKYTLVKGLKDS-----GEVVAVTG 589
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  785 DGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFSGACI 864
Cdd:cd02081  590 DGTNDAPALKKADVGFAMGIAGTEVAKEASDIILLDDNFSSIVKAVMWGRNVYDSIRKFLQFQLTVNVVAVILAFIGAVV 669
                        810       820       830       840       850
                 ....*....|....*....|....*....|....*....|....*....|..
gi 54312088  865 TQDSPLKAVQMLWVNLIMDTFASLALATEPPTDSLLRRRPYGRNKPLISRTM 916
Cdd:cd02081  670 TKDSPLTAVQMLWVNLIMDTLAALALATEPPTEDLLKRKPYGRDKPLISRTM 721
MgtA COG0474
Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];
47-1049 0e+00

Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];


Pssm-ID: 440242 [Multi-domain]  Cd Length: 874  Bit Score: 690.69  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088   47 HYGSVQEICARLKTSPvEGLSgnPADLEKRRLVFGKNMIPPKKPKTFLELVWEALQDVtliileiaaiISLVLsfyrppg 126
Cdd:COG0474    9 HALSAEEVLAELGTSE-EGLS--SEEAARRLARYGPNELPEEKKRSLLRRFLEQFKNP----------LILIL------- 68
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  127 genEICGhIVSnpeedeeGETG-WIEGAAILASVIIVVFVTAFNDWSKEKQFRGLQSRIELEQKfsIIRNGQLIQLPVAE 205
Cdd:COG0474   69 ---LAAA-VIS-------ALLGdWVDAIVILAVVLLNAIIGFVQEYRAEKALEALKKLLAPTAR--VLRDGKWVEIPAEE 135
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  206 IVVGDIAQVKYGDLLPADGILIQGNDLKIDESSLTGESDHVKKT----------LDKDPMLLSGTHVMEGSGRMVVTAVG 275
Cdd:COG0474  136 LVPGDIVLLEAGDRVPADLRLLEAKDLQVDESALTGESVPVEKSadplpedaplGDRGNMVFMGTLVTSGRGTAVVVATG 215
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  276 INSQTGIIFTLLGaneeeddekkkkgkkqgvsenrnkaktqdgvaleiqplnsqegldseekekkaskGPKKEKSVLQGK 355
Cdd:COG0474  216 MNTEFGKIAKLLQ-------------------------------------------------------EAEEEKTPLQKQ 240
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  356 LTRLAVQIGKAGLIMSILTVLILILyfvvdnfviQRRAWLpectpvyiqyfvKFFIIGVTVLVVAVPEGLPLAVTISLAY 435
Cdd:COG0474  241 LDRLGKLLAIIALVLAALVFLIGLL---------RGGPLL------------EALLFAVALAVAAIPEGLPAVVTITLAL 299
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  436 SVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTMNRMTVVQAYIGGTHYRqipkPDDLPPNVLDLIVNSICINSAYT 515
Cdd:COG0474  300 GAQRMAKRNAIVRRLPAVETLGSVTVICTDKTGTLTQNKMTVERVYTGGGTYE----VTGEFDPALEELLRAAALCSDAQ 375
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  516 skiLPPEKEgglprqVGNKTECGLLGFVTDLKQDYQAVRSEMPeekLFKVYTFNSVRKSMSTVIRKPEGGFRVFSKGASE 595
Cdd:COG0474  376 ---LEEETG------LGDPTEGALLVAAAKAGLDVEELRKEYP---RVDEIPFDSERKRMSTVHEDPDGKRLLIVKGAPE 443
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  596 IMLRKCDRILnKEGGIVPFKTKDRDNmVRNVIEPMASEGLRTIGIAYRDFDGEEPSWENENEifTGLVCIAVVGIEDPVR 675
Cdd:COG0474  444 VVLALCTRVL-TGGGVVPLTEEDRAE-ILEAVEELAAQGLRVLAVAYKELPADPELDSEDDE--SDLTFLGLVGMIDPPR 519
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  676 PEVPDAINKCKRAGITVRMVTGDNVNTARAIATKCGILTPGDDflCLEGKEFNRLirnekgevEQEKLDKVWPRLRVLAR 755
Cdd:COG0474  520 PEAKEAIAECRRAGIRVKMITGDHPATARAIARQLGLGDDGDR--VLTGAELDAM--------SDEELAEAVEDVDVFAR 589
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  756 SSPTDKHTLVKGIidsnigeQRQ--VVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWG 833
Cdd:COG0474  590 VSPEHKLRIVKAL-------QANghVVAMTGDGVNDAPALKAADIGIAMGITGTDVAKEAADIVLLDDNFATIVAAVEEG 662
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  834 RNVYDSISKFLQFQLTVNVVAVIVAFSGACITQDSPLKAVQMLWVNLIMDTFASLALATEPPTDSLLRRRPYGRNKPLIS 913
Cdd:COG0474  663 RRIYDNIRKFIKYLLSSNFGEVLSVLLASLLGLPLPLTPIQILWINLVTDGLPALALGFEPVEPDVMKRPPRWPDEPILS 742
                        890       900       910       920       930       940       950       960
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  914 RTMMKNILGHAVYqLGIVFLLVFAgdklFDIDSGrkaplnSPPSQHYTIVFNTFVLMQLFNEINSRKIHgeKNVFA-GVY 992
Cdd:COG0474  743 RFLLLRILLLGLL-IAIFTLLTFA----LALARG------ASLALARTMAFTTLVLSQLFNVFNCRSER--RSFFKsGLF 809
                        970       980       990      1000      1010
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 54312088  993 RNIIFCSVVLGTFFCQILI--VEVGGKPFSCTNLTMEQWMWCLFIGIGELLWGQVISAI 1049
Cdd:COG0474  810 PNRPLLLAVLLSLLLQLLLiyVPPLQALFGTVPLPLSDWLLILGLALLYLLLVELVKLL 868
PRK10517 PRK10517
magnesium-transporting P-type ATPase MgtA;
51-858 3.54e-47

magnesium-transporting P-type ATPase MgtA;


Pssm-ID: 236705 [Multi-domain]  Cd Length: 902  Bit Score: 183.35  E-value: 3.54e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    51 VQEICARLKTSPvEGLsgNPADLEKRRLVFGKNMIPPKKPKTFLELVWEAlqdvtliileiaaiislvlsfYRPPGgeN- 129
Cdd:PRK10517   54 EEELWKTFDTHP-EGL--NEAEVESAREQHGENELPAQKPLPWWVHLWVC---------------------YRNPF--Ni 107
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088   130 --EICGhIVSNPEEDeegetgwIEGAAILASviIVVFVTAFNDWSKEKQFRG---LQSRIEleQKFSIIRNG------QL 198
Cdd:PRK10517  108 llTILG-AISYATED-------LFAAGVIAL--MVAISTLLNFIQEARSTKAadaLKAMVS--NTATVLRVIndkgenGW 175
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088   199 IQLPVAEIVVGDIAQVKYGDLLPADGILIQGNDLKIDESSLTGESDHVKK-----------TLDKDPMLLSGTHVMEGSG 267
Cdd:PRK10517  176 LEIPIDQLVPGDIIKLAAGDMIPADLRILQARDLFVAQASLTGESLPVEKfattrqpehsnPLECDTLCFMGTNVVSGTA 255
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088   268 RMVVTAVGINsqtgiifTLLGAneeeddekkkkgKKQGVSEnrnkaktQDGvaleiQPLNSQEGLDSeekekkaskgpkk 347
Cdd:PRK10517  256 QAVVIATGAN-------TWFGQ------------LAGRVSE-------QDS-----EPNAFQQGISR------------- 291
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088   348 eKSVLqgkLTRLAvqigkagLIMsiltvlililyfvvdnfviqrrawlpecTPV--YIQYFVK-----FFIIGVTVLVVA 420
Cdd:PRK10517  292 -VSWL---LIRFM-------LVM----------------------------APVvlLINGYTKgdwweAALFALSVAVGL 332
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088   421 VPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTMNRMTVVQayiggtHYRQIPKPDDlppNV 500
Cdd:PRK10517  333 TPEMLPMIVTSTLARGAVKLSKQKVIVKRLDAIQNFGAMDILCTDKTGTLTQDKIVLEN------HTDISGKTSE---RV 403
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088   501 LDlivnSICINSAYtskilppekegglprQVGNKT-------ECGLLGFVTDLKQDYQAVrSEMPeeklfkvytFNSVRK 573
Cdd:PRK10517  404 LH----SAWLNSHY---------------QTGLKNlldtavlEGVDEESARSLASRWQKI-DEIP---------FDFERR 454
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088   574 SMSTVIRKPEGGFRVFSKGASEIMLRKCDRILNkEGGIVPFkTKDRDNMVRNVIEPMASEGLRTIGIAYRDFDGEEPSWE 653
Cdd:PRK10517  455 RMSVVVAENTEHHQLICKGALEEILNVCSQVRH-NGEIVPL-DDIMLRRIKRVTDTLNRQGLRVVAVATKYLPAREGDYQ 532
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088   654 NENEifTGLVCIAVVGIEDPVRPEVPDAINKCKRAGITVRMVTGDNVNTARAIATKCGiltpgddflcLEGKEFnrLIRN 733
Cdd:PRK10517  533 RADE--SDLILEGYIAFLDPPKETTAPALKALKASGVTVKILTGDSELVAAKVCHEVG----------LDAGEV--LIGS 598
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088   734 EKGEVEQEKLDKVWPRLRVLARSSPTDKHTLVKgiidsNIGEQRQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEA 813
Cdd:PRK10517  599 DIETLSDDELANLAERTTLFARLTPMHKERIVT-----LLKREGHVVGFMGDGINDAPALRAADIGISVD-GAVDIAREA 672
                         810       820       830       840       850
                  ....*....|....*....|....*....|....*....|....*....|
gi 54312088   814 SDIILTDDNFTSIVKAVMWGRNVYDSISKFLqfQLTV-----NVVAVIVA 858
Cdd:PRK10517  673 ADIILLEKSLMVLEEGVIEGRRTFANMLKYI--KMTAssnfgNVFSVLVA 720
Cation_ATPase_C pfam00689
Cation transporting ATPase, C-terminus; Members of this families are involved in Na+/K+, H+/K+, ...
868-1049 1.06e-44

Cation transporting ATPase, C-terminus; Members of this families are involved in Na+/K+, H+/K+, Ca++ and Mg++ transport. This family represents 5 transmembrane helices.


Pssm-ID: 376368 [Multi-domain]  Cd Length: 175  Bit Score: 159.33  E-value: 1.06e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    868 SPLKAVQMLWVNLIMDTFASLALATEPPTDSLLRRRPYGRNKPLISRTMMKNILGHAVYQLGIVFLLVFAGDKLFDIDSG 947
Cdd:pfam00689    2 LPLTPIQILWINLVTDGLPALALGFEPPEPDLMKRPPRKPKEPLFSRKMLRRILLQGLLIAILTLLVFFLGLLGFGISES 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    948 RKAplnsppsqhYTIVFNTFVLMQLFNEINSRKIHGEKNVFaGVYRNIIFCSVVLGTFFCQILIVEV--GGKPFSCTNLT 1025
Cdd:pfam00689   82 QNA---------QTMAFNTLVLSQLFNALNARSLRRSLFKI-GLFSNKLLLLAILLSLLLQLLIIYVppLQAVFGTTPLS 151
                          170       180
                   ....*....|....*....|....
gi 54312088   1026 MEQWMWCLFIGIGELLWGQVISAI 1049
Cdd:pfam00689  152 LEQWLIVLLLALVVLLVVELRKLL 175
ATP_Ca_trans_C pfam12424
Plasma membrane calcium transporter ATPase C terminal; This domain family is found in ...
1089-1126 8.13e-11

Plasma membrane calcium transporter ATPase C terminal; This domain family is found in eukaryotes, and is approximately 60 amino acids in length. The family is found in association with pfam00689, pfam00122, pfam00702, pfam00690. There is a conserved QTQ sequence motif. This family is the C terminal of a calcium transporting ATPase located in the plasma membrane.


Pssm-ID: 463575  Cd Length: 47  Bit Score: 58.19  E-value: 8.13e-11
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 54312088   1089 GQILWVRGLNRIQTQIEVINKFQTGAsFKGVLRRQNLS 1126
Cdd:pfam12424    1 GQILWFRGLNRIQTQIRVVKAFQSSL-REGIQKPYLRN 37
Cation_ATPase_N smart00831
Cation transporter/ATPase, N-terminus; This entry represents the conserved N-terminal region ...
47-119 4.25e-05

Cation transporter/ATPase, N-terminus; This entry represents the conserved N-terminal region found in several classes of cation-transporting P-type ATPases, including those that transport H+, Na+, Ca2+, Na+/K+, and H+/K+. In the H+/K+- and Na+/K+-exchange P-ATPases, this domain is found in the catalytic alpha chain. In gastric H+/K+-ATPases, this domain undergoes reversible sequential phosphorylation inducing conformational changes that may be important for regulating the function of these ATPases.


Pssm-ID: 214842 [Multi-domain]  Cd Length: 75  Bit Score: 42.96  E-value: 4.25e-05
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 54312088      47 HYGSVQEICARLKTSPVEGLSgnPADLEKRRLVFGKNMIPPKKPKTFLELVWEALQDVTLIILEIAAIISLVL 119
Cdd:smart00831    5 HALSLEEVLERLQTDLEKGLS--SEEAARRLERYGPNELPPPKKTSPLLRFLRQFHNPLIYILLAAAVLSALL 75
 
Name Accession Description Interval E-value
ATPase-IIB_Ca TIGR01517
plasma-membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase ...
16-1052 0e+00

plasma-membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase responsible for translocating calcium ions across the plasma membrane of eukaryotes, out of the cell. In some organisms, this type of pump may also be found in vacuolar membranes. In humans and mice, at least, there are multiple isoforms of the PMCA pump with overlapping but not redundant functions. Accordingly, there are no human diseases linked to PMCA defects, although alterations of PMCA function do elicit physiological effects. The calcium P-type ATPases have been characterized as Type IIB based on a phylogenetic analysis which distinguishes this group from the Type IIA SERCA calcium pump. A separate analysis divides Type IIA into sub-types (SERCA and PMR1) which are represented by two corresponding models (TIGR01116 and TIGR01522). This model is well separated from those.


Pssm-ID: 273668 [Multi-domain]  Cd Length: 956  Bit Score: 1295.13  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088     16 ESYEGEFGCTLMDLRKLMELRAADAV---TQISAHYGSVQEICARLKTSPVEGLSGNPADLEKRRLVFGKNMIPPKKPKT 92
Cdd:TIGR01517    7 RTSIRDNFTDGFDVGVSILTDLTDIFkkaMPLYEKLGGAEGIATKLKTDLNEGVRLSSSTLERREKVYGKNELPEKPPKS 86
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088     93 FLELVWEALQDVTLIILEIAAIISLVLSFYRPpggeneicghivSNPEEDEEGETGWIEGAAILASVIIVVFVTAFNDWS 172
Cdd:TIGR01517   87 FLQIVWAALSDQTLILLSVAAVVSLVLGLYVP------------SVGEDKADTETGWIEGVAILVSVILVVLVTAVNDYK 154
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    173 KEKQFRGLQsRIELEQKFSIIRNGQLIQLPVAEIVVGDIAQVKYGDLLPADGILIQGNDLKIDESSLTGESDHVKKTLDK 252
Cdd:TIGR01517  155 KELQFRQLN-REKSAQKIAVIRGGQEQQISIHDIVVGDIVSLSTGDVVPADGVFISGLSLEIDESSITGESDPIKKGPVQ 233
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    253 DPMLLSGTHVMEGSGRMVVTAVGINSQTGIIFTLLGaneeeddekkkkgkkqgvsenrnkaktqdgvaleiqplnsQEGL 332
Cdd:TIGR01517  234 DPFLLSGTVVNEGSGRMLVTAVGVNSFGGKLMMELR----------------------------------------QAGE 273
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    333 DSEekekkaskgpkkeksVLQGKLTRLAVQIGKAGLIMSILTVLILILYFVVDNFVIQRRawlPECTPVYIQYFVKFFII 412
Cdd:TIGR01517  274 EET---------------PLQEKLSELAGLIGKFGMGSAVLLFLVLSLRYVFRIIRGDGR---FEDTEEDAQTFLDHFII 335
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    413 GVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTMNRMTVVQAYIGGTHYRqipK 492
Cdd:TIGR01517  336 AVTIVVVAVPEGLPLAVTIALAYSMKKMMKDNNLVRHLAACETMGSATAICSDKTGTLTQNVMSVVQGYIGEQRFN---V 412
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    493 PDDLPPNVLDLIVNSICINSAYTSKILPPEKE-GGLPRQVGNKTECGLLGFVTDLKQDYQAVRSEMPEEKLFKVYTFNSV 571
Cdd:TIGR01517  413 RDEIVLRNLPAAVRNILVEGISLNSSSEEVVDrGGKRAFIGSKTECALLDFGLLLLLQSRDVQEVRAEEKVVKIYPFNSE 492
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    572 RKSMSTVIRKPEGGFRVFSKGASEIMLRKCDRILNKEGGIVPFkTKDRDNMVRNVIEPMASEGLRTIGIAYRDFDGEE-P 650
Cdd:TIGR01517  493 RKFMSVVVKHSGGKYREFRKGASEIVLKPCRKRLDSNGEATPI-SEDDKDRCADVIEPLASDALRTICLAYRDFAPEEfP 571
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    651 SWENENeifTGLVCIAVVGIEDPVRPEVPDAINKCKRAGITVRMVTGDNVNTARAIATKCGILTPGDdfLCLEGKEFNRL 730
Cdd:TIGR01517  572 RKDYPN---KGLTLIGVVGIKDPLRPGVREAVQECQRAGITVRMVTGDNIDTAKAIARNCGILTFGG--LAMEGKEFRSL 646
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    731 IRNEkgeveqekLDKVWPRLRVLARSSPTDKHTLVKGIIDsnigeQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVA 810
Cdd:TIGR01517  647 VYEE--------MDPILPKLRVLARSSPLDKQLLVLMLKD-----MGEVVAVTGDGTNDAPALKLADVGFSMGISGTEVA 713
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    811 KEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFSGACIT--QDSPLKAVQMLWVNLIMDTFASL 888
Cdd:TIGR01517  714 KEASDIILLDDNFASIVRAVKWGRNVYDNIRKFLQFQLTVNVVAVILTFVGSCISssHTSPLTAVQLLWVNLIMDTLAAL 793
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    889 ALATEPPTDSLLRRRPYGRNKPLISRTMMKNILGHAVYQLGIVFLLVFAGDKLFDIDSGRKAPlNSPPSQHYTIVFNTFV 968
Cdd:TIGR01517  794 ALATEPPTEALLDRKPIGRNAPLISRSMWKNILGQAGYQLVVTFILLFAGGSIFDVSGPDEIT-SHQQGELNTIVFNTFV 872
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    969 LMQLFNEINSRKIHGEKNVFAGVYRNIIFCSVVLGTFFCQILIVEVGGKPFSCTNLTMEQWMWCLFIGIGELLWGQVISA 1048
Cdd:TIGR01517  873 LLQLFNEINARKLYEGMNVFEGLFKNRIFVTIMGFTFGFQVIIVEFGGSFFSTVSLSIEQWIGCVLLGMLSLIFGVLLRL 952

                   ....
gi 54312088   1049 IPTK 1052
Cdd:TIGR01517  953 IPVE 956
P-type_ATPase_Ca_PMCA-like cd02081
animal plasma membrane Ca2(+)-ATPases (PMCA), similar to human ATP2B1-4/PMCA1-4, and related ...
73-916 0e+00

animal plasma membrane Ca2(+)-ATPases (PMCA), similar to human ATP2B1-4/PMCA1-4, and related Ca2(+)-ATPases including Saccharomyces cerevisiae vacuolar PMC1; Animal PMCAs function to export Ca(2+) from cells and play a role in regulating Ca(2+) signals following stimulus induction and in preventing calcium toxicity. Many PMCA pump variants exist due to alternative splicing of transcripts. PMCAs are regulated by the binding of calmodulin or by kinase-mediated phosphorylation. Saccharomyces cerevisiae vacuolar transporter Pmc1p facilitates the accumulation of Ca2+ into vacuoles. Pmc1p is not regulated by direct calmodulin binding but responds to the calmodulin/calcineurin-signaling pathway and is controlled by the transcription factor complex Tcn1p/Crz1p. Similarly, the expression of the gene for Dictyostelium discoideum Ca(2+)-ATPase PAT1, patA, is under the control of a calcineurin-dependent transcription factor. Plant vacuolar Ca(2+)-ATPases, are regulated by direct-calmodulin binding. Plant Ca(2+)-ATPases are present at various cellular locations including the plasma membrane, endoplasmic reticulum, chloroplast and vacuole. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319776 [Multi-domain]  Cd Length: 721  Bit Score: 1280.61  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088   73 LEKRRLVFGKNMIPPKKPKTFLELVWEALQDVTLIILEIAAIISLVLSFYRPPGgeneicghivsnpeeDEEGETGWIEG 152
Cdd:cd02081    1 LEHRREVYGKNEIPPKPPKSFLQLVWEALQDPTLIILLIAAIVSLGLGFYTPFG---------------EGEGKTGWIEG 65
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  153 AAILASVIIVVFVTAFNDWSKEKQFRGLQSRIElEQKFSIIRNGQLIQLPVAEIVVGDIAQVKYGDLLPADGILIQGNDL 232
Cdd:cd02081   66 VAILVAVILVVLVTAGNDYQKEKQFRKLNSKKE-DQKVTVIRDGEVIQISVFDIVVGDIVQLKYGDLIPADGLLIEGNDL 144
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  233 KIDESSLTGESDHVKKTLD---KDPMLLSGTHVMEGSGRMVVTAVGINSQTGIIFTLLGANeeeddekkkkgkkqgvsen 309
Cdd:cd02081  145 KIDESSLTGESDPIKKTPDnqiPDPFLLSGTKVLEGSGKMLVTAVGVNSQTGKIMTLLRAE------------------- 205
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  310 rnkaktqdgvaleiqplnsqegldseekekkaskgpKKEKSVLQGKLTRLAVQIGKAGLIMSILTVLILILYFVVDNFVI 389
Cdd:cd02081  206 ------------------------------------NEEKTPLQEKLTKLAVQIGKVGLIVAALTFIVLIIRFIIDGFVN 249
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  390 QRRawlpECTPVYIQYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGT 469
Cdd:cd02081  250 DGK----SFSAEDLQEFVNFFIIAVTIIVVAVPEGLPLAVTLSLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGT 325
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  470 LTMNRMTVVQAYIGgthyrqipkpddlppnvldlivnsicinsaytskilppekegglprqvgNKTECGLLGFVTDLKQD 549
Cdd:cd02081  326 LTQNRMTVVQGYIG-------------------------------------------------NKTECALLGFVLELGGD 356
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  550 YQaVRSEMPEEKLFKVYTFNSVRKSMSTVIRKPEGGFRVFSKGASEIMLRKCDRILNKEGgIVPFKTKDRDNMVRNVIEP 629
Cdd:cd02081  357 YR-YREKRPEEKVLKVYPFNSARKRMSTVVRLKDGGYRLYVKGASEIVLKKCSYILNSDG-EVVFLTSEKKEEIKRVIEP 434
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  630 MASEGLRTIGIAYRDFDGEEP-----SWENENEIFTGLVCIAVVGIEDPVRPEVPDAINKCKRAGITVRMVTGDNVNTAR 704
Cdd:cd02081  435 MASDSLRTIGLAYRDFSPDEEptaerDWDDEEDIESDLTFIGIVGIKDPLRPEVPEAVAKCQRAGITVRMVTGDNINTAR 514
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  705 AIATKCGILTPGDDFLCLEGKEFNRLIRNEKGEVEQEKLDKVWPRLRVLARSSPTDKHTLVKGIIDSnigeqRQVVAVTG 784
Cdd:cd02081  515 AIARECGILTEGEDGLVLEGKEFRELIDEEVGEVCQEKFDKIWPKLRVLARSSPEDKYTLVKGLKDS-----GEVVAVTG 589
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  785 DGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFSGACI 864
Cdd:cd02081  590 DGTNDAPALKKADVGFAMGIAGTEVAKEASDIILLDDNFSSIVKAVMWGRNVYDSIRKFLQFQLTVNVVAVILAFIGAVV 669
                        810       820       830       840       850
                 ....*....|....*....|....*....|....*....|....*....|..
gi 54312088  865 TQDSPLKAVQMLWVNLIMDTFASLALATEPPTDSLLRRRPYGRNKPLISRTM 916
Cdd:cd02081  670 TKDSPLTAVQMLWVNLIMDTLAALALATEPPTEDLLKRKPYGRDKPLISRTM 721
MgtA COG0474
Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];
47-1049 0e+00

Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];


Pssm-ID: 440242 [Multi-domain]  Cd Length: 874  Bit Score: 690.69  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088   47 HYGSVQEICARLKTSPvEGLSgnPADLEKRRLVFGKNMIPPKKPKTFLELVWEALQDVtliileiaaiISLVLsfyrppg 126
Cdd:COG0474    9 HALSAEEVLAELGTSE-EGLS--SEEAARRLARYGPNELPEEKKRSLLRRFLEQFKNP----------LILIL------- 68
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  127 genEICGhIVSnpeedeeGETG-WIEGAAILASVIIVVFVTAFNDWSKEKQFRGLQSRIELEQKfsIIRNGQLIQLPVAE 205
Cdd:COG0474   69 ---LAAA-VIS-------ALLGdWVDAIVILAVVLLNAIIGFVQEYRAEKALEALKKLLAPTAR--VLRDGKWVEIPAEE 135
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  206 IVVGDIAQVKYGDLLPADGILIQGNDLKIDESSLTGESDHVKKT----------LDKDPMLLSGTHVMEGSGRMVVTAVG 275
Cdd:COG0474  136 LVPGDIVLLEAGDRVPADLRLLEAKDLQVDESALTGESVPVEKSadplpedaplGDRGNMVFMGTLVTSGRGTAVVVATG 215
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  276 INSQTGIIFTLLGaneeeddekkkkgkkqgvsenrnkaktqdgvaleiqplnsqegldseekekkaskGPKKEKSVLQGK 355
Cdd:COG0474  216 MNTEFGKIAKLLQ-------------------------------------------------------EAEEEKTPLQKQ 240
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  356 LTRLAVQIGKAGLIMSILTVLILILyfvvdnfviQRRAWLpectpvyiqyfvKFFIIGVTVLVVAVPEGLPLAVTISLAY 435
Cdd:COG0474  241 LDRLGKLLAIIALVLAALVFLIGLL---------RGGPLL------------EALLFAVALAVAAIPEGLPAVVTITLAL 299
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  436 SVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTMNRMTVVQAYIGGTHYRqipkPDDLPPNVLDLIVNSICINSAYT 515
Cdd:COG0474  300 GAQRMAKRNAIVRRLPAVETLGSVTVICTDKTGTLTQNKMTVERVYTGGGTYE----VTGEFDPALEELLRAAALCSDAQ 375
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  516 skiLPPEKEgglprqVGNKTECGLLGFVTDLKQDYQAVRSEMPeekLFKVYTFNSVRKSMSTVIRKPEGGFRVFSKGASE 595
Cdd:COG0474  376 ---LEEETG------LGDPTEGALLVAAAKAGLDVEELRKEYP---RVDEIPFDSERKRMSTVHEDPDGKRLLIVKGAPE 443
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  596 IMLRKCDRILnKEGGIVPFKTKDRDNmVRNVIEPMASEGLRTIGIAYRDFDGEEPSWENENEifTGLVCIAVVGIEDPVR 675
Cdd:COG0474  444 VVLALCTRVL-TGGGVVPLTEEDRAE-ILEAVEELAAQGLRVLAVAYKELPADPELDSEDDE--SDLTFLGLVGMIDPPR 519
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  676 PEVPDAINKCKRAGITVRMVTGDNVNTARAIATKCGILTPGDDflCLEGKEFNRLirnekgevEQEKLDKVWPRLRVLAR 755
Cdd:COG0474  520 PEAKEAIAECRRAGIRVKMITGDHPATARAIARQLGLGDDGDR--VLTGAELDAM--------SDEELAEAVEDVDVFAR 589
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  756 SSPTDKHTLVKGIidsnigeQRQ--VVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWG 833
Cdd:COG0474  590 VSPEHKLRIVKAL-------QANghVVAMTGDGVNDAPALKAADIGIAMGITGTDVAKEAADIVLLDDNFATIVAAVEEG 662
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  834 RNVYDSISKFLQFQLTVNVVAVIVAFSGACITQDSPLKAVQMLWVNLIMDTFASLALATEPPTDSLLRRRPYGRNKPLIS 913
Cdd:COG0474  663 RRIYDNIRKFIKYLLSSNFGEVLSVLLASLLGLPLPLTPIQILWINLVTDGLPALALGFEPVEPDVMKRPPRWPDEPILS 742
                        890       900       910       920       930       940       950       960
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  914 RTMMKNILGHAVYqLGIVFLLVFAgdklFDIDSGrkaplnSPPSQHYTIVFNTFVLMQLFNEINSRKIHgeKNVFA-GVY 992
Cdd:COG0474  743 RFLLLRILLLGLL-IAIFTLLTFA----LALARG------ASLALARTMAFTTLVLSQLFNVFNCRSER--RSFFKsGLF 809
                        970       980       990      1000      1010
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 54312088  993 RNIIFCSVVLGTFFCQILI--VEVGGKPFSCTNLTMEQWMWCLFIGIGELLWGQVISAI 1049
Cdd:COG0474  810 PNRPLLLAVLLSLLLQLLLiyVPPLQALFGTVPLPLSDWLLILGLALLYLLLVELVKLL 868
P-type_ATPase_Ca_prok cd02089
prokaryotic P-type Ca(2+)-ATPase similar to Synechococcus elongatus sp. strain PCC 7942 PacL ...
65-904 1.22e-167

prokaryotic P-type Ca(2+)-ATPase similar to Synechococcus elongatus sp. strain PCC 7942 PacL and Listeria monocytogenes LMCA1; Ca(2+) transport ATPase is a plasma membrane protein which pumps Ca(2+) ion out of the cytoplasm. This prokaryotic subfamily includes the Ca(2+)-ATPase Synechococcus elongatus PacL, Listeria monocytogenes Ca(2+)-ATPase 1 (LMCA1) which has a low Ca(2+) affinity and a high pH optimum (pH about 9) and may remove Ca(2+) from the microorganism in environmental conditions when e.g. stressed by high Ca(2+) and alkaline pH, and the Bacillus subtilis putative P-type Ca(2+)-transport ATPase encoded by the yloB gene, which is expressed during sporulation. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319781 [Multi-domain]  Cd Length: 674  Bit Score: 511.77  E-value: 1.22e-167
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088   65 GLSGNPAdlEKRRLVFGKNMIPPKKPKTFLELVWEALQDVTLIILEIAAIISLVLsfyrppggeneicghivsnpeedee 144
Cdd:cd02089    1 GLSEEEA--ERRLAKYGPNELVEKKKRSPWKKFLEQFKDFMVIVLLAAAVISGVL------------------------- 53
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  145 GEtgWIEGAAILASVIIVVFVTAFNDWSKEKQFRGLQSRIEleQKFSIIRNGQLIQLPVAEIVVGDIAQVKYGDLLPADG 224
Cdd:cd02089   54 GE--YVDAIVIIAIVILNAVLGFVQEYKAEKALAALKKMSA--PTAKVLRDGKKQEIPARELVPGDIVLLEAGDYVPADG 129
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  225 ILIQGNDLKIDESSLTGESDHVKKTLDKDP-----------MLLSGTHVMEGSGRMVVTAVGINSQTGIIFTLLganeee 293
Cdd:cd02089  130 RLIESASLRVEESSLTGESEPVEKDADTLLeedvplgdrknMVFSGTLVTYGRGRAVVTATGMNTEMGKIATLL------ 203
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  294 ddekkkkgkkqgvsenrnkaktqdgvaleiqplNSQEgldseekekkaskgpkKEKSVLQGKLTrlavQIGKaglIMSIL 373
Cdd:cd02089  204 ---------------------------------EETE----------------EEKTPLQKRLD----QLGK---RLAIA 227
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  374 TVLILILYFVVDnfVIQRRAWLPEctpvyiqyfvkfFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDAC 453
Cdd:cd02089  228 ALIICALVFALG--LLRGEDLLDM------------LLTAVSLAVAAIPEGLPAIVTIVLALGVQRMAKRNAIIRKLPAV 293
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  454 ETMGNATAICSDKTGTLTMNRMTVVQAYIggthyrqipkpddlppnvldlivnsicinsaytskilppekegglprqVGN 533
Cdd:cd02089  294 ETLGSVSVICSDKTGTLTQNKMTVEKIYT------------------------------------------------IGD 325
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  534 KTECGLLGFVTDLKQDYQAVRSEMPeeKLFKVyTFNSVRKSMSTVIRKPeGGFRVFSKGASEIMLRKCDRILnKEGGIVP 613
Cdd:cd02089  326 PTETALIRAARKAGLDKEELEKKYP--RIAEI-PFDSERKLMTTVHKDA-GKYIVFTKGAPDVLLPRCTYIY-INGQVRP 400
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  614 FKTKDRDNmVRNVIEPMASEGLRTIGIAYRDFDgeEPSWENENEIFTGLVCIAVVGIEDPVRPEVPDAINKCKRAGITVR 693
Cdd:cd02089  401 LTEEDRAK-ILAVNEEFSEEALRVLAVAYKPLD--EDPTESSEDLENDLIFLGLVGMIDPPRPEVKDAVAECKKAGIKTV 477
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  694 MVTGDNVNTARAIATKCGILTPGDdfLCLEGKEFNRLirnekgevEQEKLDKVWPRLRVLARSSPTDKHTLVKGIidsni 773
Cdd:cd02089  478 MITGDHKLTARAIAKELGILEDGD--KALTGEELDKM--------SDEELEKKVEQISVYARVSPEHKLRIVKAL----- 542
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  774 geQRQ--VVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVN 851
Cdd:cd02089  543 --QRKgkIVAMTGDGVNDAPALKAADIGVAMGITGTDVAKEAADMILTDDNFATIVAAVEEGRTIYDNIRKFIRYLLSGN 620
                        810       820       830       840       850
                 ....*....|....*....|....*....|....*....|....*....|...
gi 54312088  852 VVAVIVAFSGACITQDSPLKAVQMLWVNLIMDTFASLALATEPPTDSLLRRRP 904
Cdd:cd02089  621 VGEILTMLLAPLLGWPVPLLPIQLLWINLLTDGLPALALGVEPAEPDIMDRKP 673
ATPase_P-type TIGR01494
ATPase, P-type (transporting), HAD superfamily, subfamily IC; The P-type ATPases are a large ...
155-890 1.93e-146

ATPase, P-type (transporting), HAD superfamily, subfamily IC; The P-type ATPases are a large family of trans-membrane transporters acting on charged substances. The distinguishing feature of the family is the formation of a phosphorylated intermediate (aspartyl-phosphate) during the course of the reaction. Another common name for these enzymes is the E1-E2 ATPases based on the two isolable conformations: E1 (unphosphorylated) and E2 (phosphorylated). Generally, P-type ATPases consist of only a single subunit encompassing the ATPase and ion translocation pathway, however, in the case of the potassium (TIGR01497) and sodium/potassium (TIGR01106) varieties, these functions are split between two subunits. Additional small regulatory or stabilizing subunits may also exist in some forms. P-type ATPases are nearly ubiquitous in life and are found in numerous copies in higher organisms (at least 45 in Arabidopsis thaliana, for instance). Phylogenetic analyses have revealed that the P-type ATPase subfamily is divided up into groups based on substrate specificities and this is represented in the various subfamily and equivalog models that have been made: IA (K+) TIGR01497, IB (heavy metals) TIGR01525, IIA1 (SERCA-type Ca++) TIGR01116, IIA2 (PMR1-type Ca++) TIGR01522, IIB (PMCA-type Ca++) TIGR01517, IIC (Na+/K+, H+/K+ antiporters) TIGR01106, IID (fungal-type Na+ and K+) TIGR01523, IIIA (H+) TIGR01647, IIIB (Mg++) TIGR01524, IV (phospholipid, flippase) TIGR01652 and V (unknown specificity) TIGR01657. The crystal structure of one calcium-pumping ATPase and an analysis of the fold of the catalytic domain of the P-type ATPases have been published. These reveal that the catalytic core of these enzymes is a haloacid dehalogenase(HAD)-type aspartate-nucleophile hydrolase. The location of the ATP-binding loop in between the first and second HAD conserved catalytic motifs defines these enzymes as members of subfamily I of the HAD superfamily (see also TIGR01493, TIGR01509, TIGR01549, TIGR01544 and TIGR01545). Based on these classifications, the P-type ATPase _superfamily_ corresponds to the IC subfamily of the HAD superfamily.


Pssm-ID: 273656 [Multi-domain]  Cd Length: 545  Bit Score: 451.39  E-value: 1.93e-146
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    155 ILASVIIVVFVTAFNDWSKEKQFRGLQSRIELEQKFSIIRNGQlIQLPVAEIVVGDIAQVKYGDLLPADGILIQGnDLKI 234
Cdd:TIGR01494    2 ILFLVLLFVLLEVKQKLKAEDALRSLKDSLVNTATVLVLRNGW-KEISSKDLVPGDVVLVKSGDTVPADGVLLSG-SAFV 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    235 DESSLTGESDHVKKTLDKDP-MLLSGTHVMEGSGRMVVTAVGINSQTGIIftllganeeeddekkkkgkkqgvsenrnka 313
Cdd:TIGR01494   80 DESSLTGESLPVLKTALPDGdAVFAGTINFGGTLIVKVTATGILTTVGKI------------------------------ 129
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    314 ktqdGVALEiqplnsqEGLDSeekekkaskgpkkeKSVLQGKLTRLAVQIGKAGLIMSILTVLILILYFVVDNFviqrra 393
Cdd:TIGR01494  130 ----AVVVY-------TGFST--------------KTPLQSKADKFENFIFILFLLLLALAVFLLLPIGGWDGN------ 178
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    394 wlpectpvyiqYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTMN 473
Cdd:TIGR01494  179 -----------SIYKAILRALAVLVIAIPCALPLAVSVALAVGDARMAKKGILVKNLNALEELGKVDVICFDKTGTLTTN 247
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    474 RMTVVQAYIGGTHYRQIPkpddlppnvldlivnsicinsaytskiLPPEKEGGLPRQVGNKTECGLLGFVTDLKQdyqaV 553
Cdd:TIGR01494  248 KMTLQKVIIIGGVEEASL---------------------------ALALLAASLEYLSGHPLERAIVKSAEGVIK----S 296
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    554 RSEMPEEKLFKVYTFNSVRKSMSTVIRKPEGGFRVFSKGASEIMLRKCDRILNkeggivpfktkdrdnmVRNVIEPMASE 633
Cdd:TIGR01494  297 DEINVEYKILDVFPFSSVLKRMGVIVEGANGSDLLFVKGAPEFVLERCNNEND----------------YDEKVDEYARQ 360
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    634 GLRTIGIAYRDFDGEepsweneneiftgLVCIAVVGIEDPVRPEVPDAINKCKRAGITVRMVTGDNVNTARAIATKCGIL 713
Cdd:TIGR01494  361 GLRVLAFASKKLPDD-------------LEFLGLLTFEDPLRPDAKETIEALRKAGIKVVMLTGDNVLTAKAIAKELGID 427
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    714 tpgddflclegkefnrlirnekgeveqekldkvwprlrVLARSSPTDKHTLVKGIIdsnigEQRQVVAVTGDGTNDGPAL 793
Cdd:TIGR01494  428 --------------------------------------VFARVKPEEKAAIVEALQ-----EKGRTVAMTGDGVNDAPAL 464
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    794 KKADVGFAMGIAgtDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFSGACItqdsplkav 873
Cdd:TIGR01494  465 KKADVGIAMGSG--DVAKAAADIVLLDDDLSTIVEAVKEGRKTFSNIKKNIFWAIAYNLILIPLALLLIVI--------- 533
                          730
                   ....*....|....*..
gi 54312088    874 qmlwvNLIMDTFASLAL 890
Cdd:TIGR01494  534 -----ILLPPLLAALAL 545
P-type_ATPase_cation cd02080
P-type cation-transporting ATPase similar to Exiguobacterium aurantiacum Mna, an Na(+)-ATPase, ...
65-1037 2.34e-145

P-type cation-transporting ATPase similar to Exiguobacterium aurantiacum Mna, an Na(+)-ATPase, and Synechocystis sp. PCC 6803 PMA1, a putative Ca(2+)-ATPase; This subfamily includes the P-type Na(+)-ATPase of an alkaliphilic bacterium Exiguobacterium aurantiacum Mna and cyanobacterium Synechocystis sp. PCC 6803 PMA1, a cation-transporting ATPase which may translocate calcium. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319775 [Multi-domain]  Cd Length: 819  Bit Score: 458.27  E-value: 2.34e-145
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088   65 GLSGNPAdlEKRRLVFGKNMIPPKKPKTFLELVWEALQDVTLIILEIAAIISLVLsfyrppggeneicGHivsnpeedee 144
Cdd:cd02080    1 GLTSEEA--AERLERYGPNRLPEKKTKSPLLRFLRQFNNPLIYILLAAAVVTAFL-------------GH---------- 55
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  145 getgWIEGAAILASVIIVVFVTAFNDWSKEKQFRGLQSRieLEQKFSIIRNGQLIQLPVAEIVVGDIAQVKYGDLLPADG 224
Cdd:cd02080   56 ----WVDAIVIFGVVLINAIIGYIQEGKAEKALAAIKNM--LSPEATVLRDGKKLTIDAEELVPGDIVLLEAGDKVPADL 129
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  225 ILIQGNDLKIDESSLTGESDHVKKTLDKDP----------MLLSGTHVMEGSGRMVVTAVGINSQTGIIFTLLganeeed 294
Cdd:cd02080  130 RLIEARNLQIDESALTGESVPVEKQEGPLEedtplgdrknMAYSGTLVTAGSATGVVVATGADTEIGRINQLL------- 202
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  295 dekkkkgkkqgvsenrnkaktqdgvaleiqplnsqegldseekekkaskgpkKEKSVLQGKLTRlavQIGKAGLIMSILT 374
Cdd:cd02080  203 ----------------------------------------------------AEVEQLATPLTR---QIAKFSKALLIVI 227
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  375 VLILILYFVVdNFVIQRRAWlpectpvyiqyfVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACE 454
Cdd:cd02080  228 LVLAALTFVF-GLLRGDYSL------------VELFMAVVALAVAAIPEGLPAVITITLAIGVQRMAKRNAIIRRLPAVE 294
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  455 TMGNATAICSDKTGTLTMNRMTVVQAYIggthyrqipkpddlppnvldlivnsiCINSAYTskilppEKEGGLPRQVGNK 534
Cdd:cd02080  295 TLGSVTVICSDKTGTLTRNEMTVQAIVT--------------------------LCNDAQL------HQEDGHWKITGDP 342
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  535 TECGLLGFVTDLKQDYQAVRSEMPEEKLFKvytFNSVRKSMSTVIRKpEGGFRVFSKGASEIMLRKCDRILNkEGGIVPF 614
Cdd:cd02080  343 TEGALLVLAAKAGLDPDRLASSYPRVDKIP---FDSAYRYMATLHRD-DGQRVIYVKGAPERLLDMCDQELL-DGGVSPL 417
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  615 ktkDRDnMVRNVIEPMASEGLRTIGIAYRDFDGEEpSWENENEIFTGLVCIAVVGIEDPVRPEVPDAINKCKRAGITVRM 694
Cdd:cd02080  418 ---DRA-YWEAEAEDLAKQGLRVLAFAYREVDSEV-EEIDHADLEGGLTFLGLQGMIDPPRPEAIAAVAECQSAGIRVKM 492
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  695 VTGDNVNTARAIATKCGILTPGDdflCLEGKEFNRLirnekgevEQEKLDKVWPRLRVLARSSPTDKHTLVKGIidsniG 774
Cdd:cd02080  493 ITGDHAETARAIGAQLGLGDGKK---VLTGAELDAL--------DDEELAEAVDEVDVFARTSPEHKLRLVRAL-----Q 556
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  775 EQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNV-- 852
Cdd:cd02080  557 ARGEVVAMTGDGVNDAPALKQADIGIAMGIKGTEVAKEAADMVLADDNFATIAAAVEEGRRVYDNLKKFILFTLPTNLge 636
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  853 -VAVIVA-FSGACItqdsPLKAVQMLWVNLIMDTFASLALATEPPTDSLLRRRPYGRNKPLISRTMMKNILGHAVYQL-G 929
Cdd:cd02080  637 gLVIIVAiLFGVTL----PLTPVQILWINMVTAITLGLALAFEPAEPGIMKRPPRDPSEPLLSRELIWRILLVSLLMLgG 712
                        890       900       910       920       930       940       950       960
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  930 IVFLLVFAGDKLFDIDSGRkaplnsppsqhyTIVFNTFVLMQLFNEINSRKIH---GEKNVFAGvyrNIIFCSVVLGTFF 1006
Cdd:cd02080  713 AFGLFLWALDRGYSLETAR------------TMAVNTIVVAQIFYLFNCRSLHrsiLKLGVFSN---KILFLGIGALILL 777
                        970       980       990
                 ....*....|....*....|....*....|....*.
gi 54312088 1007 cQILIVEVggkP-----FSCTNLTMEQWMWCLFIGI 1037
Cdd:cd02080  778 -QLAFTYL---PfmnslFGTAPIDLVDWAIILLVGI 809
P-type_ATPase_SERCA cd02083
sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA), similar to mammalian ATP2A1-3/SERCA1-3; ...
47-913 1.08e-135

sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA), similar to mammalian ATP2A1-3/SERCA1-3; SERCA is a transmembrane (Ca2+)-ATPase and a major regulator of Ca(2+) homeostasis and contractility in cardiac and skeletal muscle. It re-sequesters cytoplasmic Ca(2+) to the sarco/endoplasmic reticulum store, thereby also terminating Ca(2+)-induced signaling such as in muscle contraction. Three genes (ATP2A1-3/SERCA1-3) encode SERCA pumps in mammals, further isoforms exist due to alternative splicing of transcripts. The activity of SERCA is regulated by two small membrane proteins called phospholamban and sarcolipin. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319778 [Multi-domain]  Cd Length: 979  Bit Score: 437.11  E-value: 1.08e-135
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088   47 HYGSVQEICARLKTSPVEGLSgnPADLEKRRLVFGKNMIPPKKPKTFLELVWEALQDVTLIILEIAAIISLVLSFYrppg 126
Cdd:cd02083    1 HSKTVEEVLAYFGVDPTRGLS--DEQVKRRREKYGPNELPAEEGKSLWELVLEQFDDLLVRILLLAAIISFVLALF---- 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  127 geneicghivsnpEEDEEGETGWIEGAAILasvIIVVFVTAFNDWskekQFRGLQSRIELEQKFS-----IIRNGQLIQ- 200
Cdd:cd02083   75 -------------EEGEEGVTAFVEPFVIL---LILIANAVVGVW----QERNAEKAIEALKEYEpemakVLRNGKGVQr 134
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  201 LPVAEIVVGDIAQVKYGDLLPADG--ILIQGNDLKIDESSLTGESDHVKKTLD--KDP---------MLLSGTHVMEGSG 267
Cdd:cd02083  135 IRARELVPGDIVEVAVGDKVPADIriIEIKSTTLRVDQSILTGESVSVIKHTDvvPDPravnqdkknMLFSGTNVAAGKA 214
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  268 RMVVTAVGINSQTGiiftllganeeeddekkkkgkkqgvsenrnkaKTQDGVAleiqplnsqeglDSEEkekkaskgpkk 347
Cdd:cd02083  215 RGVVVGTGLNTEIG--------------------------------KIRDEMA------------ETEE----------- 239
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  348 EKSVLQGKLTRLAVQIGKAGLIMSILTVLILILYFVvdnfviqrrawlpecTPVYIQYFVK----FFIIGVTVLVVAVPE 423
Cdd:cd02083  240 EKTPLQQKLDEFGEQLSKVISVICVAVWAINIGHFN---------------DPAHGGSWIKgaiyYFKIAVALAVAAIPE 304
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  424 GLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTMNRMTVVQAY---------------IGGTHYR 488
Cdd:cd02083  305 GLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVSRMFildkveddsslnefeVTGSTYA 384
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  489 QIPKPDDLP----PNVLDLIVN-----SICINSAytskiLPPEKEGGLPRQVGNKTECGLLGFV------------TDLK 547
Cdd:cd02083  385 PEGEVFKNGkkvkAGQYDGLVElaticALCNDSS-----LDYNESKGVYEKVGEATETALTVLVekmnvfntdksgLSKR 459
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  548 QDYQAVRSEMpEEKLFKVYT--FNSVRKSMSTVIR--KPEGGFRVFSKGASEIMLRKCDRILNKEGGIVPFKTKDRDNMV 623
Cdd:cd02083  460 ERANACNDVI-EQLWKKEFTleFSRDRKSMSVYCSptKASGGNKLFVKGAPEGVLERCTHVRVGGGKVVPLTAAIKILIL 538
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  624 RNVIEpMASEGLRTIGIAYRD-------FDGEEPSWENENEifTGLVCIAVVGIEDPVRPEVPDAINKCKRAGITVRMVT 696
Cdd:cd02083  539 KKVWG-YGTDTLRCLALATKDtppkpedMDLEDSTKFYKYE--TDLTFVGVVGMLDPPRPEVRDSIEKCRDAGIRVIVIT 615
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  697 GDNVNTARAIATKCGILTPGDDF--LCLEGKEFNRLirnekGEVEQEKLDKvwpRLRVLARSSPTDKHTLVKgiidsNIG 774
Cdd:cd02083  616 GDNKGTAEAICRRIGIFGEDEDTtgKSYTGREFDDL-----SPEEQREACR---RARLFSRVEPSHKSKIVE-----LLQ 682
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  775 EQRQVVAVTGDGTNDGPALKKADVGFAMGIaGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVA 854
Cdd:cd02083  683 SQGEITAMTGDGVNDAPALKKAEIGIAMGS-GTAVAKSASDMVLADDNFATIVAAVEEGRAIYNNMKQFIRYLISSNIGE 761
                        890       900       910       920       930
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 54312088  855 VIVAFSGACITQDSPLKAVQMLWVNLIMDTFASLALATEPPTDSLLRRRPYGRNKPLIS 913
Cdd:cd02083  762 VVSIFLTAALGLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMKKPPRKPDEPLIS 820
ATPase-IIA1_Ca TIGR01116
sarco/endoplasmic reticulum calcium-translocating P-type ATPase; This model describes the ...
140-1049 7.06e-130

sarco/endoplasmic reticulum calcium-translocating P-type ATPase; This model describes the P-type ATPase responsible for translocating calcium ions across the endoplasmic reticulum membrane of eukaryotes, and is of particular importance in the sarcoplasmic reticulum of skeletal and cardiac muscle in vertebrates. These pumps transfer Ca2+ from the cytoplasm to the lumen of the endoplasmic reticulum. In humans and mice, at least, there are multiple isoforms of the SERCA pump with overlapping but not redundant functions. Defects in SERCA isoforms are associated with diseases in humans. The calcium P-type ATPases have been characterized as Type IIA based on a phylogenetic analysis which distinguishes this group from the Type IIB PMCA calcium pump modelled by TIGR01517. A separate analysis divides Type IIA into sub-types, SERCA and PMR1, the latter of which is modelled by TIGR01522. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273452 [Multi-domain]  Cd Length: 917  Bit Score: 419.96  E-value: 7.06e-130
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    140 EEDEEGETGWIEGAAILASVIIVVFVTAFNDWSKEKQFRGLQSrIELEQKfSIIRNGQLIQLPVAEIVVGDIAQVKYGDL 219
Cdd:TIGR01116   27 EEGEETVTAFVEPFVILLILVANAIVGVWQERNAEKAIEALKE-YESEHA-KVLRDGRWSVIKAKDLVPGDIVELAVGDK 104
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    220 LPADGILIQGNDLKIDESSLTGESDHVKKTL-----------DKDPMLLSGTHVMEGSGRMVVTAVGINSQTGIIftllg 288
Cdd:TIGR01116  105 VPADIRVLSLKTLRVDQSILTGESVSVNKHTesvpderavnqDKKNMLFSGTLVVAGKARGVVVRTGMSTEIGKI----- 179
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    289 aneeeddekkkkgkkqgvsenrnkaktQDGVALEiqplnsqegldseekekkaskgpKKEKSVLQGKLTRLAVQIGKAGL 368
Cdd:TIGR01116  180 ---------------------------RDEMRAA-----------------------EQEDTPLQKKLDEFGELLSKVIG 209
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    369 IMSILTVLILILYFvvDNFVIQRRawlpectpvYIQYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVR 448
Cdd:TIGR01116  210 LICILVWVINIGHF--NDPALGGG---------WIQGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRKMAKKNAIVR 278
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    449 HLDACETMGNATAICSDKTGTLTMNRMTVVQAY-------------IGGTHYRQIP---KPDDLPPNVLDLIVNSICINS 512
Cdd:TIGR01116  279 KLPSVETLGCTTVICSDKTGTLTTNQMSVCKVValdpsssslnefcVTGTTYAPEGgviKDDGPVAGGQDAGLEELATIA 358
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    513 AYT--SKILPPEKEGGLPRqVGNKTECGLLGFVTDL-----KQDYQAVRSE------MPEEKLFKVYT--FNSVRKSMSt 577
Cdd:TIGR01116  359 ALCndSSLDFNERKGVYEK-VGEATEAALKVLVEKMglpatKNGVSSKRRPalgcnsVWNDKFKKLATleFSRDRKSMS- 436
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    578 VIRKPEGGFRVFSKGASEIMLRKCDRILNKEGGIVPFKTKDRDNMVRNVIEPMASEGLRTIGIAYRD-------FDGEEP 650
Cdd:TIGR01116  437 VLCKPSTGNKLFVKGAPEGVLERCTHILNGDGRAVPLTDKMKNTILSVIKEMGTTKALRCLALAFKDipdpreeDLLSDP 516
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    651 SweNENEIFTGLVCIAVVGIEDPVRPEVPDAINKCKRAGITVRMVTGDNVNTARAIATKCGILTPGDD--FLCLEGKEFN 728
Cdd:TIGR01116  517 A--NFEAIESDLTFIGVVGMLDPPRPEVADAIEKCRTAGIRVIMITGDNKETAEAICRRIGIFSPDEDvtFKSFTGREFD 594
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    729 rlirnekgEVEQEKLDKVWPRLRVLARSSPTDKHTLVKgiidsNIGEQRQVVAVTGDGTNDGPALKKADVGFAMGiAGTD 808
Cdd:TIGR01116  595 --------EMGPAKQRAACRSAVLFSRVEPSHKSELVE-----LLQEQGEIVAMTGDGVNDAPALKKADIGIAMG-SGTE 660
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    809 VAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFSGACITQDSPLKAVQMLWVNLIMDTFASL 888
Cdd:TIGR01116  661 VAKEASDMVLADDNFATIVAAVEEGRAIYNNMKQFIRYMISSNIGEVVCIFLTAALGIPEGLIPVQLLWVNLVTDGLPAT 740
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    889 ALATEPPTDSLLRRRPYGRNKPLIS-----RTMMKNI-LGHAVYQLGIVFLLV--FAGDKL-----FDIDSGRKAPLNSP 955
Cdd:TIGR01116  741 ALGFNPPDKDIMWKPPRRPDEPLITgwlffRYLVVGVyVGLATVGGFVWWYLLthFTGCDEdsfttCPDFEDPDCYVFEG 820
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    956 PSQHYTIVFNTFVLMQLFNEINSRKIHGEKnVFAGVYRNIIFCSVVLGTFFCQILIVEVGGKP--FSCTNLTMEQWMWCL 1033
Cdd:TIGR01116  821 KQPARTISLSVLVVIEMFNALNALSEDQSL-LRMPPWVNKWLIGAICLSMALHFLILYVPFLSriFGVTPLSLTDWLMVL 899
                          970
                   ....*....|....*.
gi 54312088   1034 FIGIGELLWGQVISAI 1049
Cdd:TIGR01116  900 KLSLPVILVDEVLKFF 915
P-type_ATPase_SPCA cd02085
golgi-associated secretory pathway Ca(2+) transport ATPases, similar to human ATPase secretory ...
154-1012 2.30e-127

golgi-associated secretory pathway Ca(2+) transport ATPases, similar to human ATPase secretory pathway Ca(2+) transporting 1/hSPCA1 and Saccharomyces cerevisiae Ca(2+)/Mn(2+)-transporting P-type ATPase, Pmr1p; SPCAs are Ca(2+) pumps important for the golgi-associated secretion pathway, in addition some function as Mn(2+) pumps in Mn(2+) detoxification. Saccharomyces cerevisiae Pmr1p is a high affinity Ca(2+)/Mn(2+) ATPase which transports Ca(2+) and Mn(2+) from the cytoplasm into the Golgi. Pmr1p also contributes to Cd(2+) detoxification. This subfamily includes human SPCA1 and SPCA2, encoded by the ATP2C1 and ATP2C2 genes; autosomal dominant Hailey-Hailey disease is caused by mutations in the human ATP2C1 gene. It also includes Strongylocentrotus purpuratus testis secretory pathway calcium transporting ATPase SPCA which plays an important role in fertilization. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319779 [Multi-domain]  Cd Length: 804  Bit Score: 409.87  E-value: 2.30e-127
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  154 AILASVIIVVFVTAFNDWSKEKQFRGLQSRIELEqkFSIIRNGQLIQLPVAEIVVGDIAQVKYGDLLPADGILIQGNDLK 233
Cdd:cd02085   52 SITVAILIVVTVAFVQEYRSEKSLEALNKLVPPE--CHCLRDGKLEHFLARELVPGDLVCLSIGDRIPADLRLFEATDLS 129
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  234 IDESSLTGESDHVKKTLD-------KDPMLLS-----GTHVMEGSGRMVVTAVGINSQTGIIFTLLGAneeeddekkkkg 301
Cdd:cd02085  130 IDESSLTGETEPCSKTTEvipkasnGDLTTRSniafmGTLVRCGHGKGIVIGTGENSEFGEVFKMMQA------------ 197
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  302 kkqgvsenrnkaktqdgvaleiqplnsqegldsEEKEKkaskgpkkekSVLQGKLTRLAVQIGKAGLImsILTVLILILY 381
Cdd:cd02085  198 ---------------------------------EEAPK----------TPLQKSMDKLGKQLSLYSFI--IIGVIMLIGW 232
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  382 FvvdnfviQRRAWLpectpvyiqyfvKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATA 461
Cdd:cd02085  233 L-------QGKNLL------------EMFTIGVSLAVAAIPEGLPIVVTVTLALGVMRMAKRRAIVKKLPIVETLGCVNV 293
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  462 ICSDKTGTLTMNRMTVVQayiggthyrqipkpddlppnvldLIVNSICiNSAYTSKILPPekegglprqvGNKTECGLLG 541
Cdd:cd02085  294 ICSDKTGTLTKNEMTVTK-----------------------IVTGCVC-NNAVIRNNTLM----------GQPTEGALIA 339
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  542 F-----VTDLKQDYQAVrSEMPeeklfkvytFNSVRKSMSTVIRKPEGGFR---VFSKGASEIMLRKCDRILNKEGGIVP 613
Cdd:cd02085  340 LamkmgLSDIRETYIRK-QEIP---------FSSEQKWMAVKCIPKYNSDNeeiYFMKGALEQVLDYCTTYNSSDGSALP 409
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  614 FKTKDRDnmVRNVIE-PMASEGLRTIGIAyrdfDGEEpsweNENEIFTGLVciavvGIEDPVRPEVPDAINKCKRAGITV 692
Cdd:cd02085  410 LTQQQRS--EINEEEkEMGSKGLRVLALA----SGPE----LGDLTFLGLV-----GINDPPRPGVREAIQILLESGVRV 474
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  693 RMVTGDNVNTARAIATKCGILTPGDdfLCLEGKEFNRLirnekgevEQEKLDKVWPRLRVLARSSPTDKHTLVKGIIDSN 772
Cdd:cd02085  475 KMITGDAQETAIAIGSSLGLYSPSL--QALSGEEVDQM--------SDSQLASVVRKVTVFYRASPRHKLKIVKALQKSG 544
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  773 igeqrQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNV 852
Cdd:cd02085  545 -----AVVAMTGDGVNDAVALKSADIGIAMGRTGTDVCKEAADMILVDDDFSTILAAIEEGKGIFYNIKNFVRFQLSTSI 619
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  853 VAV-IVAFSGAcITQDSPLKAVQMLWVNLIMDTFASLALATEPPTDSLLRRRPYGRNKPLISRTMMKNILGHAVYqlgIV 931
Cdd:cd02085  620 AALsLIALSTL-FNLPNPLNAMQILWINIIMDGPPAQSLGVEPVDKDVIRQPPRNVKDPILTRSLILNVLLSAAI---IV 695
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  932 F--LLVFagdkLFDIDSGRKAPLNSppsqhyTIVFNTFVLMQLFNEINSRkiHGEKNVFA-GVYRNIIFCSVVLGTFFCQ 1008
Cdd:cd02085  696 SgtLWVF----WKEMSDDNVTPRDT------TMTFTCFVFFDMFNALSCR--SQTKSIFEiGFFSNRMFLYAVGGSLIGQ 763

                 ....
gi 54312088 1009 ILIV 1012
Cdd:cd02085  764 LLVI 767
P-type_ATPase_Na_ENA cd02086
fungal-type Na(+)-ATPase, similar to the plasma membrane sodium transporters Saccharomyces ...
145-1040 8.56e-121

fungal-type Na(+)-ATPase, similar to the plasma membrane sodium transporters Saccharomyces cerevisiae Ena1p, Ena2p and Ustilago maydis Ena1, and the endoplasmic reticulum sodium transporter Ustilago maydis Ena2; Fungal-type Na(+)-ATPase (also called ENA ATPases). This subfamily includes the Saccharomyces cerevisiae plasma membrane transporters: Na(+)/Li(+)-exporting ATPase Ena1p which may also extrudes K(+), and Na(+)-exporting P-type ATPase Ena2p. It also includes Ustilago maydis plasma membrane Ena1, an K(+)/Na(+)-ATPase whose chief role is to pump Na(+) and K(+) out of the cytoplasm, especially at high pH values, and endoplasmic reticulum Ena2 ATPase which mediates Na(+) or K(+) fluxes in the ER or in other endomembranes. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319780 [Multi-domain]  Cd Length: 920  Bit Score: 395.67  E-value: 8.56e-121
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  145 GETGWIEGAAILASVIIVVFVTAFNDWSKEKQFRGLQSRIELEQKfsIIRNGQLIQLPVAEIVVGDIAQVKYGDLLPADG 224
Cdd:cd02086   52 AVKDWIEGGVIAAVIALNVIVGFIQEYKAEKTMDSLRNLSSPNAH--VIRSGKTETISSKDVVPGDIVLLKVGDTVPADL 129
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  225 ILIQGNDLKIDESSLTGES----DHVKKTLDKDP---------MLLSGTHVMEGSGRMVVTAVGINSQTGIIFTLLgane 291
Cdd:cd02086  130 RLIETKNFETDEALLTGESlpviKDAELVFGKEEdvsvgdrlnLAYSSSTVTKGRAKGIVVATGMNTEIGKIAKAL---- 205
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  292 eeddekkkkgkkqgvsenRNKAKTQDGVALeiqplnsqeglDSEEKEKKASKGPKKEKSVLQGKLTRLAVQIGKAGLIMS 371
Cdd:cd02086  206 ------------------RGKGGLISRDRV-----------KSWLYGTLIVTWDAVGRFLGTNVGTPLQRKLSKLAYLLF 256
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  372 ILTVLILILYFVVDNFVIQRRAwlpectpvyiqyfvkfFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLD 451
Cdd:cd02086  257 FIAVILAIIVFAVNKFDVDNEV----------------IIYAIALAISMIPESLVAVLTITMAVGAKRMVKRNVIVRKLD 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  452 ACETMGNATAICSDKTGTLTMNRMTVVQAYIGGthyrqipkpddlppnvldlivnSICINSAYTSKilppeKEGGLPRQV 531
Cdd:cd02086  321 ALEALGAVTDICSDKTGTLTQGKMVVRQVWIPA----------------------ALCNIATVFKD-----EETDCWKAH 373
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  532 GNKTECGLLGFVTDLKQDYQAVRS-EMPEEKLFKVYTFNSVRKSMSTV-IRKPEGGFRVFSKGASEIMLRKCDrILNKEG 609
Cdd:cd02086  374 GDPTEIALQVFATKFDMGKNALTKgGSAQFQHVAEFPFDSTVKRMSVVyYNNQAGDYYAYMKGAVERVLECCS-SMYGKD 452
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  610 GIVPFKTKDRDNMVRNViEPMASEGLRTIGIAYRDFDGEEPSWENENEIFT-------GLVCIAVVGIEDPVRPEVPDAI 682
Cdd:cd02086  453 GIIPLDDEFRKTIIKNV-ESLASQGLRVLAFASRSFTKAQFNDDQLKNITLsradaesDLTFLGLVGIYDPPRNESAGAV 531
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  683 NKCKRAGITVRMVTGDNVNTARAIATKCGILTP--------GDDFLCLEGKEFNRLIRNEKGEVEQEKLdkvwprlrVLA 754
Cdd:cd02086  532 EKCHQAGITVHMLTGDHPGTAKAIAREVGILPPnsyhysqeIMDSMVMTASQFDGLSDEEVDALPVLPL--------VIA 603
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  755 RSSPTDKhtlVKGIidSNIGEQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGR 834
Cdd:cd02086  604 RCSPQTK---VRMI--EALHRRKKFCAMTGDGVNDSPSLKMADVGIAMGLNGSDVAKDASDIVLTDDNFASIVNAIEEGR 678
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  835 NVYDSISKFLQFQLTVNVVAVIVAFSGACITQDS-----PLKAVQMLWVNLIMDTFASLALATEPPTDSLLRRRPYGRNK 909
Cdd:cd02086  679 RMFDNIQKFVLHLLAENVAQVILLLIGLAFKDEDglsvfPLSPVEILWINMVTSSFPAMGLGLEKASPDVMQRPPHDLKV 758
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  910 PLISRTMMKNILGHAVYqLGIVFLLVFAGdKLFDIDSGRkapLNSPPSQHYTI-----------VFNTFVLMQLF---NE 975
Cdd:cd02086  759 GIFTRELIIDTFVYGTF-MGVLCLASFTL-VIYGIGNGD---LGSDCNESYNSscedvfraraaVFATLTWCALIlawEV 833
                        890       900       910       920       930       940       950       960
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  976 INSRK----IHGEKN-----VFAGVYRN-IIFCSVVLG--TFFCQILIVEVGGKPFSCTNLTMEqW-----MWCLFIGIG 1038
Cdd:cd02086  834 VDMRRsffnMHPDTDspvksFFKTLWKNkFLFWSVVLGfvSVFPTLYIPVINDDVFKHTGIGWE-WglviaCTVAFFAGV 912

                 ..
gi 54312088 1039 EL 1040
Cdd:cd02086  913 EL 914
P-type_ATPases cd01431
ATP-dependent membrane-bound cation and aminophospholipid transporters; The P-type ATPases, ...
462-890 6.21e-98

ATP-dependent membrane-bound cation and aminophospholipid transporters; The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd(2+), and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.


Pssm-ID: 319764 [Multi-domain]  Cd Length: 319  Bit Score: 314.39  E-value: 6.21e-98
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  462 ICSDKTGTLTMNRMTVVQAYIggthyrqipkpddlppnvldlivnsicinsaytskilppekegglprqvgnktecgllg 541
Cdd:cd01431    2 ICSDKTGTLTKNGMTVTKLFI----------------------------------------------------------- 22
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  542 fvtdlkqdyqavrsempeeklfKVYTFNSVRKSMSTVIRKPeGGFRVFSKGASEIMLRKCDRILnkeggivpfkTKDRDN 621
Cdd:cd01431   23 ----------------------EEIPFNSTRKRMSVVVRLP-GRYRAIVKGAPETILSRCSHAL----------TEEDRN 69
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  622 MVRNVIEPMASEGLRTIGIAYRDFDGEEPswenENEIFTGLVCIAVVGIEDPVRPEVPDAINKCKRAGITVRMVTGDNVN 701
Cdd:cd01431   70 KIEKAQEESAREGLRVLALAYREFDPETS----KEAVELNLVFLGLIGLQDPPRPEVKEAIAKCRTAGIKVVMITGDNPL 145
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  702 TARAIATKCGILTPGDDFLCLEgkefnrlirnEKGEVEQEKLDKVWPRLRVLARSSPTDKHTLVKGiidsnigEQRQ--V 779
Cdd:cd01431  146 TAIAIAREIGIDTKASGVILGE----------EADEMSEEELLDLIAKVAVFARVTPEQKLRIVKA-------LQARgeV 208
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  780 VAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAF 859
Cdd:cd01431  209 VAMTGDGVNDAPALKQADVGIAMGSTGTDVAKEAADIVLLDDNFATIVEAVEEGRAIYDNIKKNITYLLANNVAEVFAIA 288
                        410       420       430
                 ....*....|....*....|....*....|.
gi 54312088  860 SGACITQDSPLKAVQMLWVNLIMDTFASLAL 890
Cdd:cd01431  289 LALFLGGPLPLLAFQILWINLVTDLIPALAL 319
P-type_ATPase cd07539
uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase ...
153-893 2.00e-95

uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase transporters of unknown function. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd2+, and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.


Pssm-ID: 319840 [Multi-domain]  Cd Length: 634  Bit Score: 318.59  E-value: 2.00e-95
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  153 AAILASVIIV-VFVTAFNDWSKEKQFRGLQSRIELEQKFSIIRNGQLIQLPVAEIVVGDIAQVKYGDLLPADGILIQGND 231
Cdd:cd07539   60 AVLIVGVLTVnAVIGGVQRLRAERALAALLAQQQQPARVVRAPAGRTQTVPAESLVPGDVIELRAGEVVPADARLLEADD 139
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  232 LKIDESSLTGESDHVKKTLDKDP---------MLLSGTHVMEGSGRMVVTAVGINSQTGIIFTLLGaneeeddekkkkgk 302
Cdd:cd07539  140 LEVDESALTGESLPVDKQVAPTPgapladracMLYEGTTVVSGQGRAVVVATGPHTEAGRAQSLVA-------------- 205
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  303 kqgvsenrnKAKTQDGVALEIQPLNSQegldseekekkaskgpkkeksvlqgkltRLAVQIGKAGLIMSiLTVLililyf 382
Cdd:cd07539  206 ---------PVETATGVQAQLRELTSQ----------------------------LLPLSLGGGAAVTG-LGLL------ 241
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  383 vvdnfviqRRAWLpectpvyiqyfVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAI 462
Cdd:cd07539  242 --------RGAPL-----------RQAVADGVSLAVAAVPEGLPLVATLAQLAAARRLSRRGVLVRSPRTVEALGRVDTI 302
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  463 CSDKTGTLTMNRMTVVQayiggthyrqipkpddlppnvldlivnsicinsaytskILPPEKEggLPrqvgnktecgllgf 542
Cdd:cd07539  303 CFDKTGTLTENRLRVVQ--------------------------------------VRPPLAE--LP-------------- 328
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  543 vtdlkqdyqavrsempeeklfkvytFNSVRKSMSTVIRKPEGGFRVFSKGASEIMLRKCDRILnKEGGIVPFKTKDRDnM 622
Cdd:cd07539  329 -------------------------FESSRGYAAAIGRTGGGIPLLAVKGAPEVVLPRCDRRM-TGGQVVPLTEADRQ-A 381
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  623 VRNVIEPMASEGLRTIGIAYRDFD-GEEPSWEN--ENEIFTGLVciavvGIEDPVRPEVPDAINKCKRAGITVRMVTGDN 699
Cdd:cd07539  382 IEEVNELLAGQGLRVLAVAYRTLDaGTTHAVEAvvDDLELLGLL-----GLADTARPGAAALIAALHDAGIDVVMITGDH 456
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  700 VNTARAIATKCGILtpgDDFLCLEGKEFNRLIRnekgeveqEKLDKVWPRLRVLARSSPTDKHTLVKGIIDSNigeqrQV 779
Cdd:cd07539  457 PITARAIAKELGLP---RDAEVVTGAELDALDE--------EALTGLVADIDVFARVSPEQKLQIVQALQAAG-----RV 520
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  780 VAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAF 859
Cdd:cd07539  521 VAMTGDGANDAAAIRAADVGIGVGARGSDAAREAADLVLTDDDLETLLDAVVEGRTMWQNVRDAVHVLLGGNLGEVMFTL 600
                        730       740       750
                 ....*....|....*....|....*....|....
gi 54312088  860 SGACITQDSPLKAVQMLWVNLIMDTFASLALATE 893
Cdd:cd07539  601 IGTAIGGGAPLNTRQLLLVNLLTDMFPALALAVE 634
P-type_ATPase cd07538
uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase ...
71-927 2.48e-94

uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase transporters of unknown function. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd2+, and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.


Pssm-ID: 319839 [Multi-domain]  Cd Length: 653  Bit Score: 315.92  E-value: 2.48e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088   71 ADLEKRRLVFGKNMIPPKKPKTFLELVWEALQDVTLIILEIAAIISLVLsfyrppggeneicghivsnpeedeeGETGwi 150
Cdd:cd07538    5 AEARRRLESGGKNELPQPKKRTLLASILDVLREPMFLLLLAAALIYFVL-------------------------GDPR-- 57
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  151 EGAAILASVIIVVFVTAFNDWSKEKQFRGLQsriELEQ-KFSIIRNGQLIQLPVAEIVVGDIAQVKYGDLLPADGILIQG 229
Cdd:cd07538   58 EGLILLIFVVVIIAIEVVQEWRTERALEALK---NLSSpRATVIRDGRERRIPSRELVPGDLLILGEGERIPADGRLLEN 134
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  230 NDLKIDESSLTGESDHVKKTLD----------KDPMLLSGTHVMEGSGRMVVTAVGINSQTGIIftllganeeeddekkk 299
Cdd:cd07538  135 DDLGVDESTLTGESVPVWKRIDgkamsapggwDKNFCYAGTLVVRGRGVAKVEATGSRTELGKI---------------- 198
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  300 kgkkqgvsenrnkaktqdGVALEiqplnsqeGLDSEEkekkaskgPKKEKSVlqGKLTRLavqIGKAGLIMSiltVLILI 379
Cdd:cd07538  199 ------------------GKSLA--------EMDDEP--------TPLQKQT--GRLVKL---CALAALVFC---ALIVA 236
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  380 LYFVVDNFVIQRrawlpectpvyiqyfvkfFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNA 459
Cdd:cd07538  237 VYGVTRGDWIQA------------------ILAGITLAMAMIPEEFPVILTVFMAMGAWRLAKKNVLVRRAAAVETLGSI 298
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  460 TAICSDKTGTLTMNRMTVVQAYIggthyrqipkpddlppnvldlivnsicinsaytskilppekegglprqvgnktecgl 539
Cdd:cd07538  299 TVLCVDKTGTLTKNQMEVVELTS--------------------------------------------------------- 321
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  540 lgfvtdlkqdyqavrsempeekLFKVYTFNSVRKSMSTVIRKPEGGFrVFSKGASEIMLRKCDrilnkeggivpFKTKDR 619
Cdd:cd07538  322 ----------------------LVREYPLRPELRMMGQVWKRPEGAF-AAAKGSPEAIIRLCR-----------LNPDEK 367
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  620 DNMVRNVIEpMASEGLRTIGIAYRDFDGEE--PSWENENEIFTGLVciavvGIEDPVRPEVPDAINKCKRAGITVRMVTG 697
Cdd:cd07538  368 AAIEDAVSE-MAGEGLRVLAVAACRIDESFlpDDLEDAVFIFVGLI-----GLADPLREDVPEAVRICCEAGIRVVMITG 441
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  698 DNVNTARAIATKCGIltpgddflclegKEFNRLIR-NEKGEVEQEKLDKVWPRLRVLARSSPTDKHTLVKGIidSNIGEq 776
Cdd:cd07538  442 DNPATAKAIAKQIGL------------DNTDNVITgQELDAMSDEELAEKVRDVNIFARVVPEQKLRIVQAF--KANGE- 506
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  777 rqVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVI 856
Cdd:cd07538  507 --IVAMTGDGVNDAPALKAAHIGIAMGKRGTDVAREASDIVLLDDNFSSIVSTIRLGRRIYDNLKKAITYVFAIHVPIAG 584
                        810       820       830       840       850       860       870
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 54312088  857 VAFSGACITQDSPLKAVQMLWVNLIMDTFASLALATEPPTDSLLRRRPYGRNKPLISrtmmKNILGHAVYQ 927
Cdd:cd07538  585 LALLPPLLGLPPLLFPVHVVLLELIIDPTCSIVFEAEPAERDIMRRPPRPPDEPLFG----PRLVIKAILQ 651
P-type_ATPase_Na-K_like cd02608
alpha-subunit of Na(+)/K(+)-ATPases and of gastric H(+)/K(+)-ATPase, similar to the human Na(+) ...
188-931 8.75e-93

alpha-subunit of Na(+)/K(+)-ATPases and of gastric H(+)/K(+)-ATPase, similar to the human Na(+)/K(+)-ATPase alpha subunits 1-4; This subfamily includes the alpha subunit of Na(+)/K(+)-ATPase a heteromeric transmembrane protein composed of an alpha- and beta-subunit and an optional third subunit belonging to the FXYD proteins which are more tissue specific regulatory subunits of the enzyme. The alpha-subunit is the catalytic subunit responsible for transport activities of the enzyme. This subfamily includes all four isotopes of the human alpha subunit: (alpha1-alpha4, encoded by the ATP1A1- ATP1A4 genes). Na(+)/K(+)-ATPase functions chiefly as an ion pump, hydrolyzing one molecule of ATP to pump three Na(+) out of the cell in exchange for two K(+)entering the cell per pump cycle. In addition Na(+)/K(+)-ATPase acts as a signal transducer. This subfamily also includes Oreochromis mossambicus (tilapia) Na(+)/K(+)-ATPase alpha 1 and alpha 3 subunits, and gastric H(+)/K(+)-ATPase which exchanges hydronium ion with potassium and is responsible for gastric acid secretion. Gastric H(+)/K(+)-ATPase is an alpha,beta-heterodimeric enzyme. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319794 [Multi-domain]  Cd Length: 905  Bit Score: 318.52  E-value: 8.75e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  188 QKFSIIRNGQLIQLPVAEIVVGDIAQVKYGDLLPADGILIQGNDLKIDESSLTGESDHVKKTLD---KDPM------LLS 258
Cdd:cd02608  106 QQALVIRDGEKMQINAEELVVGDLVEVKGGDRIPADIRIISAHGCKVDNSSLTGESEPQTRSPEfthENPLetkniaFFS 185
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  259 gTHVMEGSGRMVVTAVGINSQTGIIFTLlganeeeddekkkkgkkqgvsenrnkaktqdgvaleiqplnsQEGLDSEEke 338
Cdd:cd02608  186 -TNCVEGTARGIVINTGDRTVMGRIATL------------------------------------------ASGLEVGK-- 220
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  339 kkaskgpkkeksvlqgklTRLAVQIGKAGLIMSILTVLILILYFVVdNFVIQRRaWLPECtpvyiqyfvkFFIIGVtvlV 418
Cdd:cd02608  221 ------------------TPIAREIEHFIHIITGVAVFLGVSFFIL-SLILGYT-WLEAV----------IFLIGI---I 267
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  419 VA-VPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTMNRMTVVQAYIGGthyrQIPKPDDLP 497
Cdd:cd02608  268 VAnVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDN----QIHEADTTE 343
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  498 PN-------------VLDLIVnSICiNSAytsKILPPEKEGGLPRQV--GNKTECGLLGFVTDLKQDYQAVRSEMPeeKL 562
Cdd:cd02608  344 DQsgasfdkssatwlALSRIA-GLC-NRA---EFKAGQENVPILKRDvnGDASESALLKCIELSCGSVMEMRERNP--KV 416
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  563 FKVyTFNSVRK---SMSTVIRKPEGGFRVFSKGASEIMLRKCDRILnKEGGIVPFKTKDRDNMvRNVIEPMASEGLRTIG 639
Cdd:cd02608  417 AEI-PFNSTNKyqlSIHENEDPGDPRYLLVMKGAPERILDRCSTIL-INGKEQPLDEEMKEAF-QNAYLELGGLGERVLG 493
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  640 IAYR-----------DFDGEEPSWENENEIFTGLVCIAvvgieDPVRPEVPDAINKCKRAGITVRMVTGDNVNTARAIAT 708
Cdd:cd02608  494 FCHLylpddkfpegfKFDTDEVNFPTENLCFVGLMSMI-----DPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAK 568
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  709 KCGILtpgddflclegkefnrlirnekgeveqekldkvwprlrVLARSSPTDKHTLVKGIidsnigeQRQ--VVAVTGDG 786
Cdd:cd02608  569 GVGII--------------------------------------VFARTSPQQKLIIVEGC-------QRQgaIVAVTGDG 603
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  787 TNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNvVAVIVAFSgACITQ 866
Cdd:cd02608  604 VNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSN-IPEITPFL-IFIIA 681
                        730       740       750       760       770       780
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 54312088  867 DSPLK--AVQMLWVNLIMDTFASLALATEPPTDSLLRRRPygRNkPLISRTMMKNILGHAVYQLGIV 931
Cdd:cd02608  682 NIPLPlgTITILCIDLGTDMVPAISLAYEKAESDIMKRQP--RN-PKTDKLVNERLISMAYGQIGMI 745
ATPase-IID_K-Na TIGR01523
potassium and/or sodium efflux P-type ATPase, fungal-type; Initially described as a calcium ...
145-948 9.26e-87

potassium and/or sodium efflux P-type ATPase, fungal-type; Initially described as a calcium efflux ATPase, more recent work has shown that the S. pombe CTA3 gene is in fact a potassium ion efflux pump. This model describes the clade of fungal P-type ATPases responsible for potassium and sodium efflux. The degree to which these pumps show preference for sodium or potassium varies. This group of ATPases has been classified by phylogentic analysis as type IID. The Leishmania sequence (GP|3192903), which falls between trusted and noise in this model, may very well turn out to be an active potassium pump.


Pssm-ID: 130586 [Multi-domain]  Cd Length: 1053  Bit Score: 304.24  E-value: 9.26e-87
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    145 GETGWIEGAAILASVIIVVFVTAFNDWSKEKQFRGLQSrieLEQKFS-IIRNGQLIQLPVAEIVVGDIAQVKYGDLLPAD 223
Cdd:TIGR01523   77 AMHDWIEGGVISAIIALNILIGFIQEYKAEKTMDSLKN---LASPMAhVIRNGKSDAIDSHDLVPGDICLLKTGDTIPAD 153
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    224 GILIQGNDLKIDESSLTGESDHVKKTL-------------DKDPMLLSGTHVMEGSGRMVVTAVGINSQTGIIFTLLGAN 290
Cdd:TIGR01523  154 LRLIETKNFDTDEALLTGESLPVIKDAhatfgkeedtpigDRINLAFSSSAVTKGRAKGICIATALNSEIGAIAAGLQGD 233
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    291 EEEDDEKKKKGKKQGVSENRNKAKTQDGVALEIQPLNSqegldseekekkaskgpkkeKSVLQGKLTRLAVqigkaglIM 370
Cdd:TIGR01523  234 GGLFQRPEKDDPNKRRKLNKWILKVTKKVTGAFLGLNV--------------------GTPLHRKLSKLAV-------IL 286
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    371 SILTVLILILYFVVDNFVIQRRAwlpectpvyiqyfvkfFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHL 450
Cdd:TIGR01523  287 FCIAIIFAIIVMAAHKFDVDKEV----------------AIYAICLAISIIPESLIAVLSITMAMGAANMSKRNVIVRKL 350
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    451 DACETMGNATAICSDKTGTLTMNRMTVVQAYIGGTHYRQIPKPDDlPPNVLDLIVNSICINSAYTSK--------ILPPE 522
Cdd:TIGR01523  351 DALEALGAVNDICSDKTGTITQGKMIARQIWIPRFGTISIDNSDD-AFNPNEGNVSGIPRFSPYEYShneaadqdILKEF 429
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    523 K----EGGLPRQV--------------------------------GNKTECGLLGFVTDL-------------------K 547
Cdd:TIGR01523  430 KdelkEIDLPEDIdmdlfiklletaalaniatvfkddatdcwkahGDPTEIAIHVFAKKFdlphnaltgeedllksnenD 509
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    548 QDYQAVRSEMPEEKLFKV---YTFNSVRKSMSTVIRKPEG-GFRVFSKGASEIMLRKCDRILNKEG-GIVPFKTKDRDNM 622
Cdd:TIGR01523  510 QSSLSQHNEKPGSAQFEFiaeFPFDSEIKRMASIYEDNHGeTYNIYAKGAFERIIECCSSSNGKDGvKISPLEDCDRELI 589
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    623 VRNViEPMASEGLRTIGIAYRDFDGEEpSWENENEIFT--------GLVCIAVVGIEDPVRPEVPDAINKCKRAGITVRM 694
Cdd:TIGR01523  590 IANM-ESLAAEGLRVLAFASKSFDKAD-NNDDQLKNETlnrataesDLEFLGLIGIYDPPRNESAGAVEKCHQAGINVHM 667
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    695 VTGDNVNTARAIATKCGILTPG--------DDFLCLEGKEFNRLirnekgevEQEKLDKVWPRLRVLARSSPTDKHTLVK 766
Cdd:TIGR01523  668 LTGDFPETAKAIAQEVGIIPPNfihdrdeiMDSMVMTGSQFDAL--------SDEEVDDLKALCLVIARCAPQTKVKMIE 739
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    767 GIidsniGEQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQF 846
Cdd:TIGR01523  740 AL-----HRRKAFCAMTGDGVNDSPSLKMANVGIAMGINGSDVAKDASDIVLSDDNFASILNAIEEGRRMFDNIMKFVLH 814
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    847 QLTVNVVAVIVAFSGACITQDS-----PLKAVQMLWVNLIMDTFASLALATEPPTDSLLRRRPYGRNKPLISRTMMKNIL 921
Cdd:TIGR01523  815 LLAENVAEAILLIIGLAFRDENgksvfPLSPVEILWCIMITSCFPAMGLGLEKAAPDLMDRLPHDNEVGIFQKELIIDMF 894
                          890       900
                   ....*....|....*....|....*..
gi 54312088    922 GHAVYqLGIVFLLVFAGdKLFDIDSGR 948
Cdd:TIGR01523  895 AYGFF-LGGSCLASFTG-ILYGFGSGN 919
ATPase-IIC_X-K TIGR01106
sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit; This ...
30-926 1.27e-85

sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit; This model describes the P-type ATPases responsible for the exchange of either protons or sodium ions for potassium ions across the plasma membranes of eukaryotes. Unlike most other P-type ATPases, members of this subfamily require a beta subunit for activity. This model encompasses eukaryotes and consists of two functional types, a Na/K antiporter found widely distributed in eukaryotes and a H/K antiporter found only in vertebrates. The Na+ or H+/K+ antiporter P-type ATPases have been characterized as Type IIC based on a published phylogenetic analysis. Sequences from Blastocladiella emersonii (GP|6636502, GP|6636502 and PIR|T43025), C. elegans (GP|2315419, GP|6671808 and PIR|T31763) and Drosophila melanogaster (GP|7291424) score below trusted cutoff, apparently due to long branch length (excessive divergence from the last common ancestor) as evidenced by a phylogenetic tree. Experimental evidence is needed to determine whether these sequences represent ATPases with conserved function. Aside from fragments, other sequences between trusted and noise appear to be bacterial ATPases of unclear lineage, but most likely calcium pumps. [Energy metabolism, ATP-proton motive force interconversion]


Pssm-ID: 273445 [Multi-domain]  Cd Length: 997  Bit Score: 300.17  E-value: 1.27e-85
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088     30 RKLMELRAADAVTQisaHYGSVQEICARLKTSPVEGLSGN-PADLEKRRlvfGKNMIPPkkPKTFLELVWEALQDVTLII 108
Cdd:TIGR01106    4 RDLDELKKEVEMDD---HKLSLDELERKYGTDLSKGLSAArAAEILARD---GPNALTP--PPTTPEWVKFCRQLFGGFS 75
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    109 LEIAAIISLVLSFYRPPGGENEicghivsNPEEDEegetgwIEGAAILASVIIVVFVTAFNDWSKEKQ----FRGLqsri 184
Cdd:TIGR01106   76 MLLWIGAILCFLAYGIQASTEE-------EPQNDN------LYLGVVLSAVVIITGCFSYYQEAKSSKimesFKNM---- 138
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    185 eLEQKFSIIRNGQLIQLPVAEIVVGDIAQVKYGDLLPADGILIQGNDLKIDESSLTGESDHVKKTLD---KDPM-----L 256
Cdd:TIGR01106  139 -VPQQALVIRDGEKMSINAEQVVVGDLVEVKGGDRIPADLRIISAQGCKVDNSSLTGESEPQTRSPEfthENPLetrniA 217
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    257 LSGTHVMEGSGRMVVTAVGINSQTGIIFTLlganeeeddekkkkgkkqgvsenrnkaktqdgvaleiqplnsQEGLDSEE 336
Cdd:TIGR01106  218 FFSTNCVEGTARGIVVNTGDRTVMGRIASL------------------------------------------ASGLENGK 255
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    337 kekkaskgpkkeksvlqgklTRLAVQIGKAGLIMSILTVLILILYFVVDnfVIQRRAWLPECtpvyiqyfvkFFIIGVtv 416
Cdd:TIGR01106  256 --------------------TPIAIEIEHFIHIITGVAVFLGVSFFILS--LILGYTWLEAV----------IFLIGI-- 301
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    417 LVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTMNRMTVVQAYIGgthyRQIPKPD-- 494
Cdd:TIGR01106  302 IVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFD----NQIHEADtt 377
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    495 -DLPPNVLD---LIVNSICINSAYTSKILPPEKEGGLP---RQV-GNKTECGLLGF-------VTDLKQDYQAVrSEMPe 559
Cdd:TIGR01106  378 eDQSGVSFDkssATWLALSRIAGLCNRAVFKAGQENVPilkRAVaGDASESALLKCielclgsVMEMRERNPKV-VEIP- 455
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    560 eklfkvytFNSVRK---SMSTVIRKPEGGFRVFSKGASEIMLRKCDRILNKeGGIVPFKTKDRDnMVRNVIEPMASEGLR 636
Cdd:TIGR01106  456 --------FNSTNKyqlSIHENEDPRDPRHLLVMKGAPERILERCSSILIH-GKEQPLDEELKE-AFQNAYLELGGLGER 525
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    637 TIGIAYR-----------DFDGEEPSWENENEIFTGLVCIAvvgieDPVRPEVPDAINKCKRAGITVRMVTGDNVNTARA 705
Cdd:TIGR01106  526 VLGFCHLylpdeqfpegfQFDTDDVNFPTDNLCFVGLISMI-----DPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKA 600
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    706 IATKCGILTPGDDF-------LCLEGKEFNRliRNEKG---------EVEQEKLDKVwprLR-----VLARSSPTDKHTL 764
Cdd:TIGR01106  601 IAKGVGIISEGNETvediaarLNIPVSQVNP--RDAKAcvvhgsdlkDMTSEQLDEI---LKyhteiVFARTSPQQKLII 675
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    765 VKGIidsnigeQRQ--VVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISK 842
Cdd:TIGR01106  676 VEGC-------QRQgaIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKK 748
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    843 FLQFQLTVNV--VAVIVAFSGACITQdsPLKAVQMLWVNLIMDTFASLALATEPPTDSLLRRRPYGR------NKPLISR 914
Cdd:TIGR01106  749 SIAYTLTSNIpeITPFLIFIIANIPL--PLGTITILCIDLGTDMVPAISLAYEKAESDIMKRQPRNPktdklvNERLISM 826
                          970
                   ....*....|....*..
gi 54312088    915 T-----MMKNILGHAVY 926
Cdd:TIGR01106  827 AygqigMIQALGGFFTY 843
P-type_ATPase_Mg cd02077
magnesium transporting ATPase (MgtA), similar to Escherichia coli MgtA and Salmonella ...
65-898 6.84e-76

magnesium transporting ATPase (MgtA), similar to Escherichia coli MgtA and Salmonella typhimurium MgtA; MgtA is a membrane protein which actively transports Mg(2+) into the cytosol with its electro-chemical gradient rather than against the gradient as other cation transporters do. It may act both as a transporter and as a sensor for Mg(2+). In Salmonella typhimurium and Escherichia coli, the two-component system PhoQ/PhoP regulates the transcription of the mgtA gene by sensing Mg(2+) concentrations in the periplasm. MgtA is activated by cardiolipin and it highly sensitive to free magnesium in vitro. It consists of a transmembrane domain and three cytosolic domains: nucleotide-binding domain, phosphorylation domain and actuator domain, and belongs to the P-type ATPase type III subfamily. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319772 [Multi-domain]  Cd Length: 768  Bit Score: 267.58  E-value: 6.84e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088   65 GLSGNPAdlEKRRLVFGKNMIPPKKPKTFLELVWEALQDVTLIILEIAAIISLVLSFYRPPGGENeicghivsnpeedee 144
Cdd:cd02077    1 GLTNEEA--EERLEKYGPNEISHEKFPSWFKLLLKAFINPFNIVLLVLALVSFFTDVLLAPGEFD--------------- 63
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  145 getgwIEGAAILASVIIVVFVTAF-NDWSKEKQFRGLQSRIELeqKFSIIRNGQLIQ-LPVAEIVVGDIAQVKYGDLLPA 222
Cdd:cd02077   64 -----LVGALIILLMVLISGLLDFiQEIRSLKAAEKLKKMVKN--TATVIRDGSKYMeIPIDELVPGDIVYLSAGDMIPA 136
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  223 DGILIQGNDLKIDESSLTGESDHVKKT-----------LDKDPMLLSGTHVMEGSGRMVVTAVGINsqtgiifTLLGane 291
Cdd:cd02077  137 DVRIIQSKDLFVSQSSLTGESEPVEKHatakktkdesiLELENICFMGTNVVSGSALAVVIATGND-------TYFG--- 206
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  292 eeddekkkkgkkqgvsenrNKAKTqdgvaleiqpLNSQEGLDSEEKE-KKASKgpkkeksvlqgkltrlavqigkagLIM 370
Cdd:cd02077  207 -------------------SIAKS----------ITEKRPETSFDKGiNKVSK------------------------LLI 233
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  371 SILTVLILILYFVVdnfVIQRRAWLpectpvyiqyfvKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHL 450
Cdd:cd02077  234 RFMLVMVPVVFLIN---GLTKGDWL------------EALLFALAVAVGLTPEMLPMIVTSNLAKGAVRMSKRKVIVKNL 298
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  451 DACETMGNATAICSDKTGTLTMNRMTVVQAYiggthyrqipkpdDLPPNVLDLIVNSICINSAYTSKILPPekeggLPRQ 530
Cdd:cd02077  299 NAIQNFGAMDILCTDKTGTLTQDKIVLERHL-------------DVNGKESERVLRLAYLNSYFQTGLKNL-----LDKA 360
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  531 VGNKTECGLLGFvtdLKQDYQAVrSEMPeeklfkvytFNSVRKSMSTVIRKPEGGFRVFSKGASEIMLRKCDRIlNKEGG 610
Cdd:cd02077  361 IIDHAEEANANG---LIQDYTKI-DEIP---------FDFERRRMSVVVKDNDGKHLLITKGAVEEILNVCTHV-EVNGE 426
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  611 IVPFKTKDRdNMVRNVIEPMASEGLRTIGIAYRDFDGEEPSWENENEifTGLVCIAVVGIEDPVRPEVPDAINKCKRAGI 690
Cdd:cd02077  427 VVPLTDTLR-EKILAQVEELNREGLRVLAIAYKKLPAPEGEYSVKDE--KELILIGFLAFLDPPKESAAQAIKALKKNGV 503
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  691 TVRMVTGDNVNTARAIATKCGILTPGddflCLEGKEFNRLirnekgevEQEKLDKVWPRLRVLARSSPTDKHTlvkgIID 770
Cdd:cd02077  504 NVKILTGDNEIVTKAICKQVGLDINR----VLTGSEIEAL--------SDEELAKIVEETNIFAKLSPLQKAR----IIQ 567
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  771 SnIGEQRQVVAVTGDGTNDGPALKKADVGFAMGIAgTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTV 850
Cdd:cd02077  568 A-LKKNGHVVGFMGDGINDAPALRQADVGISVDSA-VDIAKEAADIILLEKDLMVLEEGVIEGRKTFGNILKYIKMTASS 645
                        810       820       830       840       850
                 ....*....|....*....|....*....|....*....|....*....|.
gi 54312088  851 N---VVAVIVAfsgACITQDSPLKAVQMLWVNLIMDtFASLALatepPTDS 898
Cdd:cd02077  646 NfgnVFSVLVA---SAFLPFLPMLPIQLLLQNLLYD-FSQLAI----PFDN 688
P-type_ATPase_H cd02076
plant and fungal plasma membrane H(+)-ATPases, and related bacterial and archaeal putative H(+) ...
65-1049 2.01e-73

plant and fungal plasma membrane H(+)-ATPases, and related bacterial and archaeal putative H(+)-ATPases; This subfamily includes eukaryotic plasma membrane H(+)-ATPase which transports H(+) from the cytosol to the extracellular space, thus energizing the plasma membrane for the uptake of ions and nutrients, and is expressed in plants and fungi. This H(+)-ATPase consists of four domains: a transmembrane domain and three cytosolic domains: nucleotide-binding domain, phosphorylation domain and actuator domain, and belongs to the P-type ATPase type III subfamily. This subfamily also includes the putative P-type H(+)-ATPase, MJ1226p of the anaerobic hyperthermophilic archaea Methanococcus jannaschii. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319771 [Multi-domain]  Cd Length: 781  Bit Score: 260.62  E-value: 2.01e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088   65 GLSgnPADLEKRRLVFGKNMIPPKKPKTFLElvwealqdvtliileiaaiislVLSFYrppggeneicghivSNPeedee 144
Cdd:cd02076    1 GLT--SEEAAKRLKEYGPNELPEKKENPILK----------------------FLSFF--------------WGP----- 37
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  145 geTGW-IEGAAILA--------SVIIVV--FVTAFNDWSKEKQFRGLQSRIE--LEQKFSIIRNGQLIQLPVAEIVVGDI 211
Cdd:cd02076   38 --IPWmLEAAAILAaalgdwvdFAIILLllLINAGIGFIEERQAGNAVAALKksLAPKARVLRDGQWQEIDAKELVPGDI 115
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  212 AQVKYGDLLPADGILIQGNDLKIDESSLTGESDHVKKTldKDPMLLSGTHVMEGSGRMVVTAVGINSQTGiiftllgane 291
Cdd:cd02076  116 VSLKIGDIVPADARLLTGDALQVDQSALTGESLPVTKH--PGDEAYSGSIVKQGEMLAVVTATGSNTFFG---------- 183
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  292 eeddekkkkgkkqgvsenrnkaKTqdgVALeiqpLNSQEGldseekekkaskgpkkeksvlQGKLTRLAVQIGKAGLIMS 371
Cdd:cd02076  184 ----------------------KT---AAL----VASAEE---------------------QGHLQKVLNKIGNFLILLA 213
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  372 ILTVLILILYfvvdnfviqrrAWLPECTPVYIQYFVkffiigVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLD 451
Cdd:cd02076  214 LILVLIIVIV-----------ALYRHDPFLEILQFV------LVLLIASIPVAMPAVLTVTMAVGALELAKKKAIVSRLS 276
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  452 ACETMGNATAICSDKTGTLTMNRMTVVQayiggthyrQIPKPDDLPPNVLDLivnsicinSAYTSKilpPEKEGGLPRQV 531
Cdd:cd02076  277 AIEELAGVDILCSDKTGTLTLNKLSLDE---------PYSLEGDGKDELLLL--------AALASD---TENPDAIDTAI 336
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  532 gnktecglLGFVTDLKQDyqavrseMPEEKLFKVYTFNSVRK-SMSTVIRKPEGGFRVfSKGASEIMLRKCDrilnkegg 610
Cdd:cd02076  337 --------LNALDDYKPD-------LAGYKQLKFTPFDPVDKrTEATVEDPDGERFKV-TKGAPQVILELVG-------- 392
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  611 ivpfKTKDRDNMVRNVIEPMASEGLRTIGIAYRDfdgEEPSWEneneiFTGLVCIAvvgieDPVRPEVPDAINKCKRAGI 690
Cdd:cd02076  393 ----NDEAIRQAVEEKIDELASRGYRSLGVARKE---DGGRWE-----LLGLLPLF-----DPPRPDSKATIARAKELGV 455
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  691 TVRMVTGDNVNTARAIATKCGIltpGDDFLCLEGKEFNRLIRNEKGEVEQEKLDKVwprlRVLARSSPTDKHTLVKgiid 770
Cdd:cd02076  456 RVKMITGDQLAIAKETARQLGM---GTNILSAERLKLGGGGGGMPGSELIEFIEDA----DGFAEVFPEHKYRIVE---- 524
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  771 snIGEQR-QVVAVTGDGTNDGPALKKADVGFAMGIAgTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLT 849
Cdd:cd02076  525 --ALQQRgHLVGMTGDGVNDAPALKKADVGIAVSGA-TDAARAAADIVLTAPGLSVIIDAIKTSRQIFQRMKSYVIYRIA 601
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  850 VnVVAVIVAFSGACITQDSPLKAVQMLWVNLIMDTFASLALATEpptdsllrRRPYgRNKPLISRtmMKNILGHAVYqLG 929
Cdd:cd02076  602 E-TLRILVFFTLGILILNFYPLPLIMIVLIAILNDGATLTIAYD--------NVPP-SPRPVRWN--MPELLGIATV-LG 668
                        890       900       910       920       930       940       950       960
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  930 IV-----FLLVFAGDKLFdidSGRKAPLNSPPSQhyTIVFNTFVLMQLFNEINSRKIHGEKNVFAGVYRNI-IFCSVVLG 1003
Cdd:cd02076  669 VVltissFLLLWLLDDQG---WFEDIVLSAGELQ--TILYLQLSISGHLTIFVTRTRGPFWRPRPSPLLFIaVVLTQILA 743
                        970       980       990      1000
                 ....*....|....*....|....*....|....*....|....*.
gi 54312088 1004 TFFCqiliveVGGkPFSCTNLTmeqWMWCLFIGIGELLWGQVISAI 1049
Cdd:cd02076  744 TLLA------VYG-WFMFAGIG---WGWALLVWIYALVWFVVLDFV 779
P-type_ATPase cd02609
uncharacterized subfamily of P-type ATPase transporter, similar to uncharacterized ...
189-925 2.49e-61

uncharacterized subfamily of P-type ATPase transporter, similar to uncharacterized Streptococcus pneumoniae exported protein 7, Exp7; This subfamily contains P-type ATPase transporters of unknown function, similar to Streptococcus pneumoniae Exp7. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd(2+), and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.


Pssm-ID: 319795 [Multi-domain]  Cd Length: 661  Bit Score: 222.54  E-value: 2.49e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  189 KFSIIRNGQLIQLPVAEIVVGDIAQVKYGDLLPADGILIQGNDLKIDESSLTGESDHVKKtlDKDPMLLSGTHVMEGSGR 268
Cdd:cd02609   93 KVTVIRDGQEVKIPPEELVLDDILILKPGEQIPADGEVVEGGGLEVDESLLTGESDLIPK--KAGDKLLSGSFVVSGAAY 170
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  269 MVVTAVGINSQtgiiftllganeeeddekkkkgkkqgVSENRNKAKTQdgvaleiqplnsqegldseekekkaskgpKKE 348
Cdd:cd02609  171 ARVTAVGAESY--------------------------AAKLTLEAKKH-----------------------------KLI 195
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  349 KSVLQGKLTRLAVQIGKagLIMSILTVLILILYFVVDNfvIQRRAwlpectpvyiqyfvkffIIG-VTVLVVAVPEGLPL 427
Cdd:cd02609  196 NSELLNSINKILKFTSF--IIIPLGLLLFVEALFRRGG--GWRQA-----------------VVStVAALLGMIPEGLVL 254
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  428 AVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTMNRMTVVQAYIGGTHYRQIPkpddlpPNVLDLIVNS 507
Cdd:cd02609  255 LTSVALAVGAIRLAKKKVLVQELYSIETLARVDVLCLDKTGTITEGKMKVERVEPLDEANEAEA------AAALAAFVAA 328
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  508 ICINSAyTSKILppekeggLPRQVGNktecgllgfvtdlkqDYQAVRSEMPeeklfkvytFNSVRKSMStvIRKPEGGfr 587
Cdd:cd02609  329 SEDNNA-TMQAI-------RAAFFGN---------------NRFEVTSIIP---------FSSARKWSA--VEFRDGG-- 372
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  588 VFSKGASEIMLRkcdrilnkeggivpfktkDRDNMVRNVIEPMASEGLRTIGIAYRDfdgEEPSWEnenEIFTGLVCIAV 667
Cdd:cd02609  373 TWVLGAPEVLLG------------------DLPSEVLSRVNELAAQGYRVLLLARSA---GALTHE---QLPVGLEPLAL 428
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  668 VGIEDPVRPEVPDAINKCKRAGITVRMVTGDNVNTARAIATKCGiltpgddflcLEGKEfnRLIRNEKGEVEqEKLDKVW 747
Cdd:cd02609  429 ILLTDPIRPEAKETLAYFAEQGVAVKVISGDNPVTVSAIAKRAG----------LEGAE--SYIDASTLTTD-EELAEAV 495
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  748 PRLRVLARSSPTDKHTLVKGIidsnigeQRQ--VVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDDNFTS 825
Cdd:cd02609  496 ENYTVFGRVTPEQKRQLVQAL-------QALghTVAMTGDGVNDVLALKEADCSIAMA-SGSDATRQVAQVVLLDSDFSA 567
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  826 IVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFSGACITQDSPLKAVQMLWVNLIMDTFASLALATEPPTdsllrRRPY 905
Cdd:cd02609  568 LPDVVFEGRRVVNNIERVASLFLVKTIYSVLLALICVITALPFPFLPIQITLISLFTIGIPSFFLALEPNK-----RRIE 642
                        730       740
                 ....*....|....*....|
gi 54312088  906 GRnkplisrtMMKNILGHAV 925
Cdd:cd02609  643 GG--------FLRRVLTKAL 654
ZntA COG2217
Cation-transporting P-type ATPase [Inorganic ion transport and metabolism];
157-861 3.26e-54

Cation-transporting P-type ATPase [Inorganic ion transport and metabolism];


Pssm-ID: 441819 [Multi-domain]  Cd Length: 717  Bit Score: 202.68  E-value: 3.26e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  157 ASVIIVVFVTA---FNDWSKEKQFRGLQSRIELEQKF-SIIRNGQLIQLPVAEIVVGDIAQVKYGDLLPADGILIQGNDL 232
Cdd:COG2217  178 AAAMIIFLLLLgryLEARAKGRARAAIRALLSLQPKTaRVLRDGEEVEVPVEELRVGDRVLVRPGERIPVDGVVLEGESS 257
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  233 kIDESSLTGESDHVKKTLDkDPmLLSGTHVMEGSGRMVVTAVGINSQ-TGIIftllganeeeddekkkkgkkqgvsenrn 311
Cdd:COG2217  258 -VDESMLTGESLPVEKTPG-DE-VFAGTINLDGSLRVRVTKVGSDTTlARII---------------------------- 306
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  312 kaktqdgvaleiqplnsqeGLDSEEKEKKAskgpkkeksvlqgKLTRLAVQIGKaglimsILTVLILILYFVVdnFVIqr 391
Cdd:COG2217  307 -------------------RLVEEAQSSKA-------------PIQRLADRIAR------YFVPAVLAIAALT--FLV-- 344
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  392 raWLpectpVYIQYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLT 471
Cdd:COG2217  345 --WL-----LFGGDFSTALYRAVAVLVIACPCALGLATPTAIMVGTGRAARRGILIKGGEALERLAKVDTVVFDKTGTLT 417
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  472 MNRMTVVQAyiggthyrqIPKPDDLPPNVLDLIVN---------SICINSAYTSKILPPEKegglPRQVGNKTECGLLGF 542
Cdd:COG2217  418 EGKPEVTDV---------VPLDGLDEDELLALAAAleqgsehplARAIVAAAKERGLELPE----VEDFEAIPGKGVEAT 484
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  543 VtdlkqdyqavrsempEEKLFKVytfnsvrksmstvirkpeggfrvfskGASEIMlrkcdrilnKEGGIvpfktkDRDNM 622
Cdd:COG2217  485 V---------------DGKRVLV--------------------------GSPRLL---------EEEGI------DLPEA 508
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  623 VRNVIEPMASEGLRTIGIAyrdFDGEepsweneneiftglvCIAVVGIEDPVRPEVPDAINKCKRAGITVRMVTGDNVNT 702
Cdd:COG2217  509 LEERAEELEAEGKTVVYVA---VDGR---------------LLGLIALADTLRPEAAEAIAALKALGIRVVMLTGDNERT 570
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  703 ARAIATKCGIltpgDDflclegkefnrlirnekgeveqekldkvwprlrVLARSSPTDKHTLVKgiidsNIGEQRQVVAV 782
Cdd:COG2217  571 AEAVARELGI----DE---------------------------------VRAEVLPEDKAAAVR-----ELQAQGKKVAM 608
                        650       660       670       680       690       700       710
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 54312088  783 TGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFSG 861
Cdd:COG2217  609 VGDGINDAPALAAADVGIAMG-SGTDVAIEAADIVLMRDDLRGVPDAIRLSRATMRIIRQNLFWAFGYNVIGIPLAAGG 686
ATPase-IB_hvy TIGR01525
heavy metal translocating P-type ATPase; This model encompasses two equivalog models for the ...
149-861 3.83e-54

heavy metal translocating P-type ATPase; This model encompasses two equivalog models for the copper and cadmium-type heavy metal transporting P-type ATPases (TIGR01511 and TIGR01512) as well as those species which score ambiguously between both models. For more comments and references, see the files on TIGR01511 and 01512.


Pssm-ID: 273669 [Multi-domain]  Cd Length: 558  Bit Score: 199.01  E-value: 3.83e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    149 WIEGAAILASVIIVVFVTA--FNDWSKEKQFRGLQSRIEL--EQKFSIIRNGQLIQLPVAEIVVGDIAQVKYGDLLPADG 224
Cdd:TIGR01525   13 YAMGLVLEGALLLFLFLLGetLEERAKSRASDALSALLALapSTARVLQGDGSEEEVPVEELQVGDIVIVRPGERIPVDG 92
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    225 ILIQGNDLkIDESSLTGESDHV-KKTLDKdpmLLSGTHVMEGSGRMVVTAVGINSQTGIIFTLLganeeeddekkkkgkk 303
Cdd:TIGR01525   93 VVISGESE-VDESALTGESMPVeKKEGDE---VFAGTINGDGSLTIRVTKLGEDSTLAQIVELV---------------- 152
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    304 qgvsenrnkaktqdgvaleiqplnsqegldseeKEKKASKGPkkeksvLQGKLTRLAVQIGKAGLIMSILTVLILILYFV 383
Cdd:TIGR01525  153 ---------------------------------EEAQSSKAP------IQRLADRIASYYVPAVLAIALLTFVVWLALGA 193
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    384 VDNFVIQRrawlpectpvyiqyfvkffiiGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAIC 463
Cdd:TIGR01525  194 LWREALYR---------------------ALTVLVVACPCALGLATPVAILVAIGAAARRGILIKGGDALEKLAKVKTVV 252
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    464 SDKTGTLTMNRMTVVQAYiggthyrqiPKPDDlppnvldlivnsicinsaytskilppekegglprqvgnkTECGLLGFV 543
Cdd:TIGR01525  253 FDKTGTLTTGKPTVVDIE---------PLDDA---------------------------------------SEEELLALA 284
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    544 TDLKQdyqavRSEMPEEKLFKVYT----FNSVRKSMSTVirkPEGGFRVFSKGASEIMLRKCDRILNKEGGIVPfktkdr 619
Cdd:TIGR01525  285 AALEQ-----SSSHPLARAIVRYAkergLELPPEDVEEV---PGKGVEATVDGGREVRIGNPRFLGNRELAIEP------ 350
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    620 dnmVRNVIEPMASEGLRTIGIAYRDFDGEEpsweneneiftglvcIAVVGIEDPVRPEVPDAINKCKRAG-ITVRMVTGD 698
Cdd:TIGR01525  351 ---ISASPDLLNEGESQGKTVVFVAVDGEL---------------LGVIALRDQLRPEAKEAIAALKRAGgIKLVMLTGD 412
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    699 NVNTARAIATKCGILTpgddflclegkefnrlirnekgeveqekldkvwprlRVLARSSPTDKHTLVKgiidsNIGEQRQ 778
Cdd:TIGR01525  413 NRSAAEAVAAELGIDD------------------------------------EVHAELLPEDKLAIVK-----KLQEEGG 451
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    779 VVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVA 858
Cdd:TIGR01525  452 PVAMVGDGINDAPALAAADVGIAMG-SGSDVAIEAADIVLLNDDLRSLPTAIDLSRKTRRIIKQNLAWALGYNLVAIPLA 530

                   ...
gi 54312088    859 FSG 861
Cdd:TIGR01525  531 AGG 533
P-type_ATPase_Cu-like cd02094
P-type heavy metal-transporting ATPase, similar to human copper-transporting ATPases, ATP7A ...
157-830 1.95e-47

P-type heavy metal-transporting ATPase, similar to human copper-transporting ATPases, ATP7A and ATP7B; The mammalian copper-transporting P-type ATPases, ATP7A and ATP7B are key molecules required for the regulation and maintenance of copper homeostasis. Menkes and Wilson diseases are caused by mutation in ATP7A and ATP7B respectively. This subfamily includes other copper-transporting ATPases such as: Bacillus subtilis CopA , Archeaoglobus fulgidus CopA, and Saccharomyces cerevisiae Ccc2p. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319783 [Multi-domain]  Cd Length: 647  Bit Score: 181.14  E-value: 1.95e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  157 ASVIIVVFVTA---FNDWSKEKQFRGLQSRIELEQK-FSIIRNGQLIQLPVAEIVVGDIAQVKYGDLLPADGILIQGNDL 232
Cdd:cd02094  104 AAAVIITFILLgkyLEARAKGKTSEAIKKLLGLQPKtARVIRDGKEVEVPIEEVQVGDIVRVRPGEKIPVDGVVVEGESS 183
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  233 kIDESSLTGESDHVKKTLDkDPmLLSGTHVMEGSGRMVVTAVGINSQTGIIFTLLganeeeddekkkkgkkqgvsenrnk 312
Cdd:cd02094  184 -VDESMLTGESLPVEKKPG-DK-VIGGTINGNGSLLVRATRVGADTTLAQIIRLV------------------------- 235
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  313 aktqdgvaleiqplnsqegldseeKEKKASKGPkkeksvlqgkLTRLAVQIgkAG------LIMSILTVLIlilyfvvdn 386
Cdd:cd02094  236 ------------------------EEAQGSKAP----------IQRLADRV--SGvfvpvvIAIAILTFLV--------- 270
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  387 fviqrraWL---PECTPVYIqyfvkfFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAIC 463
Cdd:cd02094  271 -------WLllgPEPALTFA------LVAAVAVLVIACPCALGLATPTAIMVGTGRAAELGILIKGGEALERAHKVDTVV 337
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  464 SDKTGTLTMNRMTVVqayiggthyrqipkpddlppnvlDLIVnsicinsaytskilppekegglprqVGNKTECGLLGFV 543
Cdd:cd02094  338 FDKTGTLTEGKPEVT-----------------------DVVP-------------------------LPGDDEDELLRLA 369
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  544 TDLKQdyqavRSEMP---------EEK---LFKVYTFNSVR-KSMSTVIrkpeGGFRVFSkGASEIMLRKCDRILNKEgg 610
Cdd:cd02094  370 ASLEQ-----GSEHPlakaivaaaKEKgleLPEVEDFEAIPgKGVRGTV----DGRRVLV-GNRRLMEENGIDLSALE-- 437
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  611 ivpfktkdrdnmvrNVIEPMASEGLRTIGIAYrdfDGEepsweneneiftglvCIAVVGIEDPVRPEVPDAINKCKRAGI 690
Cdd:cd02094  438 --------------AEALALEEEGKTVVLVAV---DGE---------------LAGLIAVADPLKPDAAEAIEALKKMGI 485
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  691 TVRMVTGDNVNTARAIATKCGIltpgDDflclegkefnrlirnekgeveqekldkvwprlrVLARSSPTDKHTLVKgiid 770
Cdd:cd02094  486 KVVMLTGDNRRTARAIAKELGI----DE---------------------------------VIAEVLPEDKAEKVK---- 524
                        650       660       670       680       690       700
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  771 sNIGEQRQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDDNFTSIVKAV 830
Cdd:cd02094  525 -KLQAQGKKVAMVGDGINDAPALAQADVGIAIG-SGTDVAIESADIVLMRGDLRGVVTAI 582
PRK10517 PRK10517
magnesium-transporting P-type ATPase MgtA;
51-858 3.54e-47

magnesium-transporting P-type ATPase MgtA;


Pssm-ID: 236705 [Multi-domain]  Cd Length: 902  Bit Score: 183.35  E-value: 3.54e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    51 VQEICARLKTSPvEGLsgNPADLEKRRLVFGKNMIPPKKPKTFLELVWEAlqdvtliileiaaiislvlsfYRPPGgeN- 129
Cdd:PRK10517   54 EEELWKTFDTHP-EGL--NEAEVESAREQHGENELPAQKPLPWWVHLWVC---------------------YRNPF--Ni 107
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088   130 --EICGhIVSNPEEDeegetgwIEGAAILASviIVVFVTAFNDWSKEKQFRG---LQSRIEleQKFSIIRNG------QL 198
Cdd:PRK10517  108 llTILG-AISYATED-------LFAAGVIAL--MVAISTLLNFIQEARSTKAadaLKAMVS--NTATVLRVIndkgenGW 175
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088   199 IQLPVAEIVVGDIAQVKYGDLLPADGILIQGNDLKIDESSLTGESDHVKK-----------TLDKDPMLLSGTHVMEGSG 267
Cdd:PRK10517  176 LEIPIDQLVPGDIIKLAAGDMIPADLRILQARDLFVAQASLTGESLPVEKfattrqpehsnPLECDTLCFMGTNVVSGTA 255
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088   268 RMVVTAVGINsqtgiifTLLGAneeeddekkkkgKKQGVSEnrnkaktQDGvaleiQPLNSQEGLDSeekekkaskgpkk 347
Cdd:PRK10517  256 QAVVIATGAN-------TWFGQ------------LAGRVSE-------QDS-----EPNAFQQGISR------------- 291
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088   348 eKSVLqgkLTRLAvqigkagLIMsiltvlililyfvvdnfviqrrawlpecTPV--YIQYFVK-----FFIIGVTVLVVA 420
Cdd:PRK10517  292 -VSWL---LIRFM-------LVM----------------------------APVvlLINGYTKgdwweAALFALSVAVGL 332
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088   421 VPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTMNRMTVVQayiggtHYRQIPKPDDlppNV 500
Cdd:PRK10517  333 TPEMLPMIVTSTLARGAVKLSKQKVIVKRLDAIQNFGAMDILCTDKTGTLTQDKIVLEN------HTDISGKTSE---RV 403
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088   501 LDlivnSICINSAYtskilppekegglprQVGNKT-------ECGLLGFVTDLKQDYQAVrSEMPeeklfkvytFNSVRK 573
Cdd:PRK10517  404 LH----SAWLNSHY---------------QTGLKNlldtavlEGVDEESARSLASRWQKI-DEIP---------FDFERR 454
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088   574 SMSTVIRKPEGGFRVFSKGASEIMLRKCDRILNkEGGIVPFkTKDRDNMVRNVIEPMASEGLRTIGIAYRDFDGEEPSWE 653
Cdd:PRK10517  455 RMSVVVAENTEHHQLICKGALEEILNVCSQVRH-NGEIVPL-DDIMLRRIKRVTDTLNRQGLRVVAVATKYLPAREGDYQ 532
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088   654 NENEifTGLVCIAVVGIEDPVRPEVPDAINKCKRAGITVRMVTGDNVNTARAIATKCGiltpgddflcLEGKEFnrLIRN 733
Cdd:PRK10517  533 RADE--SDLILEGYIAFLDPPKETTAPALKALKASGVTVKILTGDSELVAAKVCHEVG----------LDAGEV--LIGS 598
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088   734 EKGEVEQEKLDKVWPRLRVLARSSPTDKHTLVKgiidsNIGEQRQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEA 813
Cdd:PRK10517  599 DIETLSDDELANLAERTTLFARLTPMHKERIVT-----LLKREGHVVGFMGDGINDAPALRAADIGISVD-GAVDIAREA 672
                         810       820       830       840       850
                  ....*....|....*....|....*....|....*....|....*....|
gi 54312088   814 SDIILTDDNFTSIVKAVMWGRNVYDSISKFLqfQLTV-----NVVAVIVA 858
Cdd:PRK10517  673 ADIILLEKSLMVLEEGVIEGRRTFANMLKYI--KMTAssnfgNVFSVLVA 720
P-type_ATPase_HM cd02079
P-type heavy metal-transporting ATPase; Heavy metal-transporting ATPases (Type IB ATPases) ...
157-861 2.31e-46

P-type heavy metal-transporting ATPase; Heavy metal-transporting ATPases (Type IB ATPases) transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. These ATPases include mammalian copper-transporting ATPases, ATP7A and ATP7B, Bacillus subtilis CadA which transports cadmium, zinc and cobalt out of the cell, Bacillus subtilis ZosA/PfeT which transports copper, and perhaps also zinc and ferrous iron, Archaeoglobus fulgidus CopA and CopB, Staphylococcus aureus plasmid pI258 CadA, a cadmium-efflux ATPase, and Escherichia coli ZntA which is selective for Pb(2+), Zn(2+), and Cd(2+). The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This family belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319774 [Multi-domain]  Cd Length: 617  Bit Score: 177.02  E-value: 2.31e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  157 ASVIIVVFVT---AFNDWSKEKQFRGLQSRIELEQKFSI-IRNGQLIQLPVAEIVVGDIAQVKYGDLLPADGILIQGNDL 232
Cdd:cd02079   90 EAAMLLFLFLlgrYLEERARSRARSALKALLSLAPETATvLEDGSTEEVPVDDLKVGDVVLVKPGERIPVDGVVVSGESS 169
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  233 kIDESSLTGESDHVKKTLDkDPmLLSGTHVMEGSGRMVVTAVGINSQTGIIFTLLganeeeddekkkkgkkqgvsenrnk 312
Cdd:cd02079  170 -VDESSLTGESLPVEKGAG-DT-VFAGTINLNGPLTIEVTKTGEDTTLAKIIRLV------------------------- 221
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  313 aktqdgvaleiqplnsqegldsEEKEKkaskgpkkEKSVLQGKLTRLAVQIGKAGLIMSILTVLIlilyfvvdnfviqrr 392
Cdd:cd02079  222 ----------------------EEAQS--------SKPPLQRLADRFARYFTPAVLVLAALVFLF--------------- 256
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  393 awlpecTPVYIQYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTM 472
Cdd:cd02079  257 ------WPLVGGPPSLALYRALAVLVVACPCALGLATPTAIVAGIGRAARKGILIKGGDVLETLAKVDTVAFDKTGTLTE 330
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  473 NRMTVVQAyiggthyrqIPKPDDLPPNVLDLIVnSIcinsaytskilppEKEGGLPrqvgnktecglLGfvtdlkqdyQA 552
Cdd:cd02079  331 GKPEVTEI---------EPLEGFSEDELLALAA-AL-------------EQHSEHP-----------LA---------RA 367
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  553 VRSEMPEEklfkvytfnsvrksmsTVIRKPEGGFRVFS-KGASEimlrkcdRILNKEGGIVPFKTKDRDNMVRNVIEPMA 631
Cdd:cd02079  368 IVEAAEEK----------------GLPPLEVEDVEEIPgKGISG-------EVDGREVLIGSLSFAEEEGLVEAADALSD 424
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  632 SEGLRTIGIAyrdFDGEEpsweneneiftglvcIAVVGIEDPVRPEVPDAINKCKRAGITVRMVTGDNVNTARAIATKCG 711
Cdd:cd02079  425 AGKTSAVYVG---RDGKL---------------VGLFALEDQLRPEAKEVIAELKSGGIKVVMLTGDNEAAAQAVAKELG 486
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  712 ILtpgddflclegkefnrlirnekgeveqekldkvwprlRVLARSSPTDKHTLVKgiidsNIGEQRQVVAVTGDGTNDGP 791
Cdd:cd02079  487 ID-------------------------------------EVHAGLLPEDKLAIVK-----ALQAEGGPVAMVGDGINDAP 524
                        650       660       670       680       690       700       710
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  792 ALKKADVGFAMGiAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFSG 861
Cdd:cd02079  525 ALAQADVGIAMG-SGTDVAIETADIVLLSNDLSKLPDAIRLARRTRRIIKQNLAWALGYNAIALPLAALG 593
Cation_ATPase_C pfam00689
Cation transporting ATPase, C-terminus; Members of this families are involved in Na+/K+, H+/K+, ...
868-1049 1.06e-44

Cation transporting ATPase, C-terminus; Members of this families are involved in Na+/K+, H+/K+, Ca++ and Mg++ transport. This family represents 5 transmembrane helices.


Pssm-ID: 376368 [Multi-domain]  Cd Length: 175  Bit Score: 159.33  E-value: 1.06e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    868 SPLKAVQMLWVNLIMDTFASLALATEPPTDSLLRRRPYGRNKPLISRTMMKNILGHAVYQLGIVFLLVFAGDKLFDIDSG 947
Cdd:pfam00689    2 LPLTPIQILWINLVTDGLPALALGFEPPEPDLMKRPPRKPKEPLFSRKMLRRILLQGLLIAILTLLVFFLGLLGFGISES 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    948 RKAplnsppsqhYTIVFNTFVLMQLFNEINSRKIHGEKNVFaGVYRNIIFCSVVLGTFFCQILIVEV--GGKPFSCTNLT 1025
Cdd:pfam00689   82 QNA---------QTMAFNTLVLSQLFNALNARSLRRSLFKI-GLFSNKLLLLAILLSLLLQLLIIYVppLQAVFGTTPLS 151
                          170       180
                   ....*....|....*....|....
gi 54312088   1026 MEQWMWCLFIGIGELLWGQVISAI 1049
Cdd:pfam00689  152 LEQWLIVLLLALVVLLVVELRKLL 175
ATPase-IB2_Cd TIGR01512
heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; This model describes the P-type ...
149-861 4.64e-43

heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; This model describes the P-type ATPase primarily responsible for translocating cadmium ions (and other closely-related divalent heavy metals such as cobalt, mercury, lead and zinc) across biological membranes. These transporters are found in prokaryotes and plants. Experimentally characterized members of the seed alignment include: SP|P37617 from E. coli, SP|Q10866 from Mycobacterium tuberculosis and SP|Q59998 from Synechocystis PCC6803. The cadmium P-type ATPases have been characterized as Type IB based on a phylogenetic analysis which combines the copper-translocating ATPases with the cadmium-translocating species. This model and that describing the copper-ATPases (TIGR01511) are well separated, and thus we further type the copper-ATPases as IB1 and the cadmium-ATPases as IB2. Several sequences which have not been characterized experimentally fall just below trusted cutoff for both of these models (SP|Q9CCL1 from Mycobacterium leprae, GP|13816263 from Sulfolobus solfataricus, OMNI|NTL01CJ01098 from Campylobacter jejuni, OMNI|NTL01HS01687 from Halobacterium sp., GP|6899169 from Ureaplasma urealyticum and OMNI|HP1503 from Helicobacter pylori). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273665 [Multi-domain]  Cd Length: 550  Bit Score: 165.96  E-value: 4.64e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    149 WIEGAAILasvIIVVFVTAFNDWSKEKQFRGLQSRIELE-QKFSIIRNGQLIQLPVAEIVVGDIAQVKYGDLLPADGILI 227
Cdd:TIGR01512   18 YLEGALLL---LLFSIGETLEEYASGRARRALKALMELApDTARRLQGDSLEEVAVEELKVGDVVVVKPGERVPVDGEVL 94
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    228 QGNDLkIDESSLTGESDHVKKTldKDPMLLSGTHVMEGSGRMVVTAVGINSQTGIIFTLLganeeeddekkkkgkkqgVS 307
Cdd:TIGR01512   95 SGTSS-VDESALTGESVPVEKA--PGDEVFAGAINLDGVLTIEVTKLPADSTIAKIVNLV------------------EE 153
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    308 ENRNKAKTQdgvaleiqplnsqegldseekekkaskgpkkeksvlqgkltRLAVQIGKaglIMSILTVLILILYFVVDNF 387
Cdd:TIGR01512  154 AQSRKAPTQ-----------------------------------------RFIDRFAR---YYTPAVLAIALAAALVPPL 189
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    388 ViqrRAWLpectpvyiqyFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKT 467
Cdd:TIGR01512  190 L---GAGP----------FLEWIYRALVLLVVASPCALVISAPAAYLSAISAAARHGILIKGGAALEALAKIKTVAFDKT 256
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    468 GTLTMNRMTVVQAyiggthyrqIPKPDDLPPNVLDLIVN---------SICINSAYTSKILPPEkegglPRQVGNKTECG 538
Cdd:TIGR01512  257 GTLTTGKPKVTDV---------HPADGHSESEVLRLAAAaeqgsthplARAIVDYARARELAPP-----VEDVEEVPGEG 322
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    539 LLGFVtdlkqdyqavrsempeeklfkvytfnsvrksmstvirkpeGGFRVFskgaseimlrkcdriLNKEGGIVPFKTKD 618
Cdd:TIGR01512  323 VRAVV----------------------------------------DGGEVR---------------IGNPRSLSEAVGAS 347
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    619 RDNMvrnviepmaSEGLRTIGIAYRDfdgeepswenenEIFTGLVCIavvgiEDPVRPEVPDAINKCKRAGI-TVRMVTG 697
Cdd:TIGR01512  348 IAVP---------ESAGKTIVLVARD------------GTLLGYIAL-----SDELRPDAAEAIAELKALGIkRLVMLTG 401
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    698 DNVNTARAIATKCGIltpgDDflclegkefnrlirnekgeveqekldkvwprlrVLARSSPTDKHTLVKGIIDSNigeqr 777
Cdd:TIGR01512  402 DRRAVAEAVARELGI----DE---------------------------------VHAELLPEDKLEIVKELREKA----- 439
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    778 QVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIV 857
Cdd:TIGR01512  440 GPVAMVGDGINDAPALAAADVGIAMGASGSDVALETADVVLLNDDLSRLPQAIRLARRTRRIIKQNVVIALGIILVLILL 519

                   ....
gi 54312088    858 AFSG 861
Cdd:TIGR01512  520 ALFG 523
ATPase-IB1_Cu TIGR01511
copper-(or silver)-translocating P-type ATPase; This model describes the P-type ATPase ...
195-858 2.16e-40

copper-(or silver)-translocating P-type ATPase; This model describes the P-type ATPase primarily responsible for translocating copper ions accross biological membranes. These transporters are found in prokaryotes and eukaryotes. This model encompasses those species which pump copper ions out of cells or organelles (efflux pumps such as CopA of Escherichia coli) as well as those which pump the ion into cells or organelles either for the purpose of supporting life in extremely low-copper environments (for example CopA of Enterococcus hirae) or for the specific delivery of copper to a biological complex for which it is a necessary component (for example FixI of Bradyrhizobium japonicum, or CtaA and PacS of Synechocystis). The substrate specificity of these transporters may, to a varying degree, include silver ions (for example, CopA from Archaeoglobus fulgidus). Copper transporters from this family are well known as the genes which are mutated in two human disorders of copper metabolism, Wilson's and Menkes' diseases. The sequences contributing to the seed of this model are all experimentally characterized. The copper P-type ATPases have been characterized as Type IB based on a phylogenetic analysis which combines the copper-translocating ATPases with the cadmium-translocating species. This model and that describing the cadmium-ATPases (TIGR01512) are well separated, and thus we further type the copper-ATPases as IB1 (and the cadmium-ATPases as IB2). Several sequences which have not been characterized experimentally fall just below the cutoffs for both of these models (SP|Q9CCL1 from Mycobacterium leprae, GP|13816263 from Sulfolobus solfataricus, OMNI|NTL01CJ01098 from Campylobacter jejuni, OMNI|NTL01HS01687 from Halobacterium sp., GP|6899169 from Ureaplasma urealyticum and OMNI|HP1503 from Helicobacter pylori). Accession PIR|A29576 from Enterococcus faecalis scores very high against this model, but yet is annotated as an "H+/K+ exchanging ATPase". BLAST of this sequence does not hit anything else annotated in this way. This error may come from the characterization paper published in 1987. Accession GP|7415611 from Saccharomyces cerevisiae appears to be mis-annotated as a cadmium resistance protein. Accession OMNI|NTL01HS00542 from Halobacterium which scores above trusted for this model is annotated as "molybdenum-binding protein" although no evidence can be found for this classification. [Cellular processes, Detoxification, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273664 [Multi-domain]  Cd Length: 562  Bit Score: 158.21  E-value: 2.16e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    195 NGQLIQLPVAEIVVGDIAQVKYGDLLPADGILIQGNDlKIDESSLTGESDHVKKTLDkDPmLLSGTHVMEGSGRMVVTAV 274
Cdd:TIGR01511   99 DGSIEEVPVALLQPGDIVKVLPGEKIPVDGTVIEGES-EVDESLVTGESLPVPKKVG-DP-VIAGTVNGTGSLVVRATAT 175
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    275 GINSQTGIIFTLLganeeeddekkkkgkkqgvsenrnkaktqdgvaleiqplnsqegldseeKEKKASKGPkkeksvlqg 354
Cdd:TIGR01511  176 GEDTTLAQIVRLV-------------------------------------------------RQAQQSKAP--------- 197
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    355 kLTRLAvqiGKAGLIMSILTVLILILYFVVdnfviqrraWLpectpvyiqyfvkF-FIIGVTVLVVAVPEGLPLAVTISL 433
Cdd:TIGR01511  198 -IQRLA---DKVAGYFVPVVIAIALITFVI---------WL-------------FaLEFAVTVLIIACPCALGLATPTVI 251
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    434 AYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTMNRMTVVQAYiggthyrqiPKPDDLPPNVLDLIvnsicinsa 513
Cdd:TIGR01511  252 AVATGLAAKNGVLIKDGDALERAANIDTVVFDKTGTLTQGKPTVTDVH---------VFGDRDRTELLALA--------- 313
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    514 ytskilppekeGGLprqvgnktecgllgfvtdlkqdyqAVRSEMP---------EEKLFKVYTFNSVRKSmstvirkPEG 584
Cdd:TIGR01511  314 -----------AAL------------------------EAGSEHPlakaivsyaKEKGITLVTVSDFKAI-------PGI 351
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    585 GFRVFSKGAsEIMLRKCDRILnkeggivpfktkdrdnmvRNVIEPMASEGLRTIGIaYRDFDGEEpsweneneiftglvc 664
Cdd:TIGR01511  352 GVEGTVEGT-KIQLGNEKLLG------------------ENAIKIDGKAGQGSTVV-LVAVNGEL--------------- 396
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    665 IAVVGIEDPVRPEVPDAINKCKRAGITVRMVTGDNVNTARAIATKCGIltpgddflclegkefnrlirnekgeveqekld 744
Cdd:TIGR01511  397 AGVFALEDQLRPEAKEVIQALKRRGIEPVMLTGDNRKTAKAVAKELGI-------------------------------- 444
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    745 kvwprlRVLARSSPTDKHTLVKgiidsNIGEQRQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDDNFT 824
Cdd:TIGR01511  445 ------DVRAEVLPDDKAALIK-----KLQEKGPVVAMVGDGINDAPALAQADVGIAIG-AGTDVAIEAADVVLLRNDLN 512
                          650       660       670
                   ....*....|....*....|....*....|....
gi 54312088    825 SIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVA 858
Cdd:TIGR01511  513 DVATAIDLSRKTLRRIKQNLLWAFGYNVIAIPIA 546
P-type_ATPase_APLT_Dnf-like cd02073
Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, ...
147-859 1.41e-39

Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C; Aminophospholipid translocases (APLTs), also known as type 4 P-type ATPases, act as flippases, and translocate specific phospholipids from the exoplasmic leaflet to the cytoplasmic leaflet of biological membranes. Yeast Dnf1 and Dnf2 mediate the transport of phosphatidylethanolamine, phosphatidylserine, and phosphatidylcholine from the outer to the inner leaflet of the plasma membrane. This subfamily includes mammalian flippases such as ATP11C which may selectively transports PS and PE from the outer leaflet of the plasma membrane to the inner leaflet. It also includes Arabidopsis phospholipid flippases including ALA1, and Caenorhabditis elegans flippases, including TAT-1, the latter has been shown to facilitate the inward transport of phosphatidylserine. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319770 [Multi-domain]  Cd Length: 836  Bit Score: 158.87  E-value: 1.41e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  147 TGWIEGAAILASVIIVvfvTA----FNDWSKEKQFRGLQSRieleqKFSIIRNGQLIQLPVAEIVVGDIAQVKYGDLLPA 222
Cdd:cd02073   46 TGPYTTLLPLLFVLGV---TAikegYEDIRRHKSDNEVNNR-----PVQVLRGGKFVKKKWKDIRVGDIVRVKNDEFVPA 117
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  223 DGILIQGNDLK----IDESSLTGESDH-VKKTLDKDPMLLSGTHVMEGSGRMVV--------TAVG---INSQTGIIFT- 285
Cdd:cd02073  118 DLLLLSSSEPDglcyVETANLDGETNLkIRQALPETALLLSEEDLARFSGEIECeqpnndlyTFNGtleLNGGRELPLSp 197
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  286 ---LL-GANEeeddekkkkgkkqgvsenRNKAKTQdGVALEIqplnsqeGLDSeeKEKKASKGPKKEKSVLQGKLTRLAV 361
Cdd:cd02073  198 dnlLLrGCTL------------------RNTEWVY-GVVVYT-------GHET--KLMLNSGGTPLKRSSIEKKMNRFII 249
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  362 qigkagLIMSILTVLILIL----YFVVDNFVIQRRAWLPECTP-VYIQYFVKF--FIIgvtVLVVAVPegLPLAVTISLA 434
Cdd:cd02073  250 ------AIFCILIVMCLISaigkGIWLSKHGRDLWYLLPKEERsPALEFFFDFltFII---LYNNLIP--ISLYVTIEVV 318
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  435 YSV--------KKMMKDNN----LVRHLDACETMGNATAICSDKTGTLTMNRMTVVQAYIGGTHYRQipkpddlppnvld 502
Cdd:cd02073  319 KFLqsffinwdLDMYDEETdtpaEARTSNLNEELGQVEYIFSDKTGTLTENIMEFKKCSINGVDYGF------------- 385
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  503 LIVNSICiNSAYTSKILPPEK---------EGGLPRQvgnkteCGLLGFV-TDLKQDYqAVRSEMPEEKLFK---VYTFN 569
Cdd:cd02073  386 FLALALC-HTVVPEKDDHPGQlvyqasspdEAALVEA------ARDLGFVfLSRTPDT-VTINALGEEEEYEilhILEFN 457
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  570 SVRKSMSTVIRKPEGGFRVFSKGASEIMLRKCDRilnkEGGIVPFKTKDrdnmvrnVIEPMASEGLRTIGIAYRDFDGEE 649
Cdd:cd02073  458 SDRKRMSVIVRDPDGRILLYCKGADSVIFERLSP----SSLELVEKTQE-------HLEDFASEGLRTLCLAYREISEEE 526
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  650 PSWENE--------------------NEIFTGLVCIAVVGIEDPVRPEVPDAINKCKRAGITVRMVTGDNVNTARAIATK 709
Cdd:cd02073  527 YEEWNEkydeastalqnreelldevaEEIEKDLILLGATAIEDKLQDGVPETIEALQRAGIKIWVLTGDKQETAINIGYS 606
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  710 CGILTPGDDFLCL--EGKEFNrlirnekgEVEQEKLDKVWPRLRVLA------RSSPTDKHTLVKGIidsnigeQRQVVA 781
Cdd:cd02073  607 CRLLSEDMENLALviDGKTLT--------YALDPELERLFLELALKCkaviccRVSPLQKALVVKLV-------KKSKKA 671
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  782 VT---GDGTNDGPALKKADVGfaMGIAGtdvaKE------ASDIILTddNFTSIVKAVM-WGRNVYDSISKFLQFQLTVN 851
Cdd:cd02073  672 VTlaiGDGANDVSMIQEAHVG--VGISG----QEgmqaarASDYAIA--QFRFLRRLLLvHGRWSYQRLAKLILYFFYKN 743

                 ....*...
gi 54312088  852 VVAVIVAF 859
Cdd:cd02073  744 IAFYLTQF 751
P-ATPase-V TIGR01657
P-type ATPase of unknown pump specificity (type V); These P-type ATPases form a distinct clade ...
158-934 2.61e-34

P-type ATPase of unknown pump specificity (type V); These P-type ATPases form a distinct clade but the substrate of their pumping activity has yet to be determined. This clade has been designated type V in.


Pssm-ID: 273738 [Multi-domain]  Cd Length: 1054  Bit Score: 142.89  E-value: 2.61e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    158 SVIIVVFVTAFND---WSKEKQFRGLQSRIELEQKFSIIRNGQLIQLPVAEIVVGDIAQVKY--GDLLPADGILIQGnDL 232
Cdd:TIGR01657  196 SLCIVFMSSTSISlsvYQIRKQMQRLRDMVHKPQSVIVIRNGKWVTIASDELVPGDIVSIPRpeEKTMPCDSVLLSG-SC 274
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    233 KIDESSLTGESDHVKKT----------------LDKDPMLLSGTHVM-------EGSGRMVVTAVGIN-SQTGIIFTLLG 288
Cdd:TIGR01657  275 IVNESMLTGESVPVLKFpipdngdddedlflyeTSKKHVLFGGTKILqirpypgDTGCLAIVVRTGFStSKGQLVRSILY 354
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    289 ANeeeddekkkkgkkqgvsenrnkaktqdgvaleiqPLNSQEGLDSeekekkaskgpkkeksvlqGKLTRLAVQIGkagL 368
Cdd:TIGR01657  355 PK----------------------------------PRVFKFYKDS-------------------FKFILFLAVLA---L 378
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    369 IMSILTVLILILYFVVDNFVIQRrawlpeCTpvyiqyfvkffiigvTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVR 448
Cdd:TIGR01657  379 IGFIYTIIELIKDGRPLGKIILR------SL---------------DIITIVVPPALPAELSIGINNSLARLKKKGIFCT 437
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    449 HLDACETMGNATAICSDKTGTLTMNRMTVVQAYI---GGTHYRQIPKPDDLPPNVLDLIVnSICINSaytSKIlppekEG 525
Cdd:TIGR01657  438 SPFRINFAGKIDVCCFDKTGTLTEDGLDLRGVQGlsgNQEFLKIVTEDSSLKPSITHKAL-ATCHSL---TKL-----EG 508
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    526 GLprqVGNKTECGLLGFVT-------DLKQDYQ---AVRSEMPEEKL--FKVYTFNSVRKSMSTVIRKPEGGFR-VFSKG 592
Cdd:TIGR01657  509 KL---VGDPLDKKMFEATGwtleeddESAEPTSilaVVRTDDPPQELsiIRRFQFSSALQRMSVIVSTNDERSPdAFVKG 585
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    593 ASEIMLRKCDRilnkegGIVPfktKDrdnmVRNVIEPMASEGLRTIGIAYRDFDgeEPSWEN---------ENEI-FTGL 662
Cdd:TIGR01657  586 APETIQSLCSP------ETVP---SD----YQEVLKSYTREGYRVLALAYKELP--KLTLQKaqdlsrdavESNLtFLGF 650
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    663 VCIavvgiEDPVRPEVPDAINKCKRAGITVRMVTGDNVNTARAIATKCGILTP--------------------------- 715
Cdd:TIGR01657  651 IVF-----ENPLKPDTKEVIKELKRASIRTVMITGDNPLTAVHVARECGIVNPsntlilaeaeppesgkpnqikfevids 725
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    716 -------------------GDDF-----LCLEGKEFNRLIRNEKgeveqEKLDKVWPRLRVLARSSPTDKHTLVKGIIDS 771
Cdd:TIGR01657  726 ipfastqveipyplgqdsvEDLLasryhLAMSGKAFAVLQAHSP-----ELLLRLLSHTTVFARMAPDQKETLVELLQKL 800
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    772 NigeqrQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAkeASdiiltddnFTSIVKAVmwgRNVYDSIskfLQFQLT-V 850
Cdd:TIGR01657  801 D-----YTVGMCGDGANDCGALKQADVGISLSEAEASVA--AP--------FTSKLASI---SCVPNVI---REGRCAlV 859
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    851 NVVAVIVAFSGACITQ----------DSPLKAVQMLWVNLIMDTFASLALATEPPTDSLLRRRPYGRnkpLISRTMMKNI 920
Cdd:TIGR01657  860 TSFQMFKYMALYSLIQfysvsilyliGSNLGDGQFLTIDLLLIFPVALLMSRNKPLKKLSKERPPSN---LFSVYILTSV 936
                          890
                   ....*....|....*...
gi 54312088    921 LG----HAVYQLGIVFLL 934
Cdd:TIGR01657  937 LIqfvlHILSQVYLVFEL 954
P-type_ATPase_Cu-like cd07552
P-type heavy metal-transporting ATPase, similar to Archaeoglobus fulgidus CopB, a Cu(2+) ...
196-858 4.97e-34

P-type heavy metal-transporting ATPase, similar to Archaeoglobus fulgidus CopB, a Cu(2+)-ATPase; Archaeoglobus fulgidus CopB transports Cu(2+) from the cytoplasm to the exterior of the cell using ATP as energy source, it transports preferentially Cu(2+) over Cu(+), it is activated by Cu(2+) with high affinity and partially by Cu(+) and Ag(+). This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319850 [Multi-domain]  Cd Length: 632  Bit Score: 139.75  E-value: 4.97e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  196 GQLIQLPVAEIVVGDIAQVKYGDLLPADGILIQGNDLkIDESSLTGESdhvkKTLDKDP--MLLSGTHVMEGSGRMVVTA 273
Cdd:cd07552  139 GSIEDVPVSELKVGDVVLVRAGEKIPADGTILEGESS-VNESMVTGES----KPVEKKPgdEVIGGSVNGNGTLEVKVTK 213
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  274 VGINSQTGIIFTLLGaneeeddekkkkgkkqgvsenrnkaktqdgvaleiqplNSQEgldseekekkaskgpkkEKSVLQ 353
Cdd:cd07552  214 TGEDSYLSQVMELVA--------------------------------------QAQA-----------------SKSRAE 238
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  354 GKLTRLAVQIGKAGLIMSILTVLIlilyfvvdnfviqrraWLPectpvyIQYFVKFFIIGVTVLVVAVPEGL----PLAV 429
Cdd:cd07552  239 NLADKVAGWLFYIALGVGIIAFII----------------WLI------LGDLAFALERAVTVLVIACPHALglaiPLVV 296
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  430 TISLAYSVKKMMkdnnLVRHLDACETMGNATAICSDKTGTLTMNRMTVVQAYIGGTHYRQipkpddlppNVLDL------ 503
Cdd:cd07552  297 ARSTSIAAKNGL----LIRNREALERARDIDVVLFDKTGTLTEGKFGVTDVITFDEYDED---------EILSLaaalea 363
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  504 -----IVNSIcINSAYTSKILPPEKEGglprqVGNKTECGLLGFVTDlkQDYQAVRSEMPEEKLFKVYTfnsvrksmstv 578
Cdd:cd07552  364 gsehpLAQAI-VSAAKEKGIRPVEVEN-----FENIPGVGVEGTVNG--KRYQVVSPKYLKELGLKYDE----------- 424
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  579 irkpeggfrvfskgasEIMLRKCDRilnkeGGIVPFKTKDRDnmvrnviepmaseglrtigiayrdfdgeepswenenei 658
Cdd:cd07552  425 ----------------ELVKRLAQQ-----GNTVSFLIQDGE-------------------------------------- 445
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  659 ftglvCIAVVGIEDPVRPEVPDAINKCKRAGITVRMVTGDNVNTARAIATKCGILtpgddflclegkefnrlirnekgev 738
Cdd:cd07552  446 -----VIGAIALGDEIKPESKEAIRALKAQGITPVMLTGDNEEVAQAVAEELGID------------------------- 495
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  739 eqekldkvwprlRVLARSSPTDKHTLVKgiidsNIGEQRQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIIL 818
Cdd:cd07552  496 ------------EYFAEVLPEDKAKKVK-----ELQAEGKKVAMVGDGVNDAPALAQADVGIAIG-AGTDVAIESADVVL 557
                        650       660       670       680
                 ....*....|....*....|....*....|....*....|
gi 54312088  819 TDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVA 858
Cdd:cd07552  558 VKSDPRDIVDFLELAKATYRKMKQNLWWGAGYNVIAIPLA 597
PRK15122 PRK15122
magnesium-transporting ATPase; Provisional
194-890 4.98e-34

magnesium-transporting ATPase; Provisional


Pssm-ID: 237914 [Multi-domain]  Cd Length: 903  Bit Score: 141.70  E-value: 4.98e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088   194 RNGQLIQLPVAEIVVGDIAQVKYGDLLPADGILIQGNDLKIDESSLTGESDHVKK---------------------TLDK 252
Cdd:PRK15122  160 AEPVRREIPMRELVPGDIVHLSAGDMIPADVRLIESRDLFISQAVLTGEALPVEKydtlgavagksadaladdegsLLDL 239
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088   253 DPMLLSGTHVMEGSGRMVVTAVGinSQTgiIFTLLGANeeeddekkkkgkkqgVSENRNKAKTQDGValeiqplNSQEGL 332
Cdd:PRK15122  240 PNICFMGTNVVSGTATAVVVATG--SRT--YFGSLAKS---------------IVGTRAQTAFDRGV-------NSVSWL 293
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088   333 dseekekkaskgpkkeksvlqgkLTRLAvqigkagLIMsiltvlililyfvvdnfviqrrawlpecTPVYiqyfvkFFII 412
Cdd:PRK15122  294 -----------------------LIRFM-------LVM----------------------------VPVV------LLIN 309
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088   413 GVT----------VLVVAV---PEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTMNRMTVVQ 479
Cdd:PRK15122  310 GFTkgdwleallfALAVAVgltPEMLPMIVSSNLAKGAIAMARRKVVVKRLNAIQNFGAMDVLCTDKTGTLTQDRIILEH 389
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088   480 ayiggtHYRQIPKPDDlppNVLDLIvnsiCINSAYTSKILPPEKEGGLPRQVGNKTECGLLGFvtdLKQDyqavrsEMPe 559
Cdd:PRK15122  390 ------HLDVSGRKDE---RVLQLA----WLNSFHQSGMKNLMDQAVVAFAEGNPEIVKPAGY---RKVD------ELP- 446
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088   560 eklfkvytFNSVRKSMSTVIRKPEGGFRVFSKGASEIMLRKCDRILnKEGGIVPFKTKDRDNMVRnVIEPMASEGLRTIG 639
Cdd:PRK15122  447 --------FDFVRRRLSVVVEDAQGQHLLICKGAVEEMLAVATHVR-DGDTVRPLDEARRERLLA-LAEAYNADGFRVLL 516
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088   640 IAYRDFDGEEP----SWENENEiftgLVCIAVVGIEDPVRPEVPDAINKCKRAGITVRMVTGDNVNTARAIATKCGiLTP 715
Cdd:PRK15122  517 VATREIPGGESraqySTADERD----LVIRGFLTFLDPPKESAAPAIAALRENGVAVKVLTGDNPIVTAKICREVG-LEP 591
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088   716 GDDflcLEGKEFNRLirnekgevEQEKLDKVWPRLRVLARSSPTDKHTLVKGIiDSNigeqRQVVAVTGDGTNDGPALKK 795
Cdd:PRK15122  592 GEP---LLGTEIEAM--------DDAALAREVEERTVFAKLTPLQKSRVLKAL-QAN----GHTVGFLGDGINDAPALRD 655
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088   796 ADVGFAMGiAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLqfQLTV-----NVVAVIVAfsGACITQdSPL 870
Cdd:PRK15122  656 ADVGISVD-SGADIAKESADIILLEKSLMVLEEGVIKGRETFGNIIKYL--NMTAssnfgNVFSVLVA--SAFIPF-LPM 729
                         730       740
                  ....*....|....*....|
gi 54312088   871 KAVQMLWVNLIMDtFASLAL 890
Cdd:PRK15122  730 LAIHLLLQNLMYD-ISQLSL 748
ATPase-Plipid TIGR01652
phospholipid-translocating P-type ATPase, flippase; This model describes the P-type ATPase ...
156-859 5.62e-34

phospholipid-translocating P-type ATPase, flippase; This model describes the P-type ATPase responsible for transporting phospholipids from one leaflet of bilayer membranes to the other. These ATPases are found only in eukaryotes.


Pssm-ID: 273734 [Multi-domain]  Cd Length: 1057  Bit Score: 141.75  E-value: 5.62e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    156 LASVIIVVFVT-AFNDWSKEKQFRGLQSRieleqKFSIIRN-GQLIQLPVAEIVVGDIAQVKYGDLLPADGILIQGNDLK 233
Cdd:TIGR01652   57 LAFVLIVTAIKeAIEDIRRRRRDKEVNNR-----LTEVLEGhGQFVEIPWKDLRVGDIVKVKKDERIPADLLLLSSSEPD 131
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    234 ----IDESSLTGESD-HVKKTLDKDPMLLSGTHVMEGSGRmvVTAVGINSQtgiIFTLLGANEeeddekkkkgkkqgVSE 308
Cdd:TIGR01652  132 gvcyVETANLDGETNlKLRQALEETQKMLDEDDIKNFSGE--IECEQPNAS---LYSFQGNMT--------------ING 192
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    309 NRNKAKTQDGVALEIQPL-NSQE--GL----DSEEKEKKASKGPKKEKSVLQGKLTRLAVqigkagLIMSILTVLILIL- 380
Cdd:TIGR01652  193 DRQYPLSPDNILLRGCTLrNTDWviGVvvytGHDTKLMRNATQAPSKRSRLEKELNFLII------ILFCLLFVLCLISs 266
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    381 -YFVVDNFVIQRRAW---LPECTPVYIQYFVKFFIIGVTVLVVAVPegLPLAVTISLAYSVKKMMKDNNL---------- 446
Cdd:TIGR01652  267 vGAGIWNDAHGKDLWyirLDVSERNAAANGFFSFLTFLILFSSLIP--ISLYVSLELVKSVQAYFINSDLqmyhektdtp 344
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    447 --VRHLDACETMGNATAICSDKTGTLTMNRMTVVQAYIGGTHYRqipkpdDLPPNVLDLIVNSICINSAYTSKILPPEKE 524
Cdd:TIGR01652  345 asVRTSNLNEELGQVEYIFSDKTGTLTQNIMEFKKCSIAGVSYG------DGFTEIKDGIRERLGSYVENENSMLVESKG 418
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    525 GGL--PRQVGNKT----------ECGLL-----GFVTDLKQD------YQA----------------------------- 552
Cdd:TIGR01652  419 FTFvdPRLVDLLKtnkpnakrinEFFLAlalchTVVPEFNDDgpeeitYQAaspdeaalvkaardvgfvffertpksisl 498
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    553 VRSEMPEEKLFK---VYTFNSVRKSMSTVIRKPEGGFRVFSKGASEIMLRkcdrILNKEGGIVPFKTKDRdnmvrnvIEP 629
Cdd:TIGR01652  499 LIEMHGETKEYEilnVLEFNSDRKRMSVIVRNPDGRIKLLCKGADTVIFK----RLSSGGNQVNEETKEH-------LEN 567
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    630 MASEGLRTIGIAYRDFDGEE-PSWENE-------------------NEIFTGLVCIAVVGIEDPVRPEVPDAINKCKRAG 689
Cdd:TIGR01652  568 YASEGLRTLCIAYRELSEEEyEEWNEEyneastaltdreekldvvaESIEKDLILLGATAIEDKLQEGVPETIELLRQAG 647
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    690 ITVRMVTGDNVNTARAIATKCGILTPG-----------------DDFLCLEGKEFNRLIRNE------------------ 734
Cdd:TIGR01652  648 IKIWVLTGDKVETAINIGYSCRLLSRNmeqivitsdsldatrsvEAAIKFGLEGTSEEFNNLgdsgnvalvidgkslgya 727
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    735 -KGEVEQEKLDKVWPRLRVLA-RSSPTDKHTLVKGIIDSNigeQRQVVAVtGDGTNDGPALKKADVGfaMGIAGTD--VA 810
Cdd:TIGR01652  728 lDEELEKEFLQLALKCKAVICcRVSPSQKADVVRLVKKST---GKTTLAI-GDGANDVSMIQEADVG--VGISGKEgmQA 801
                          810       820       830       840       850
                   ....*....|....*....|....*....|....*....|....*....|
gi 54312088    811 KEASDIILTddNFTSIVKAVMW-GRNVYDSISKFLQFQLTVNVVAVIVAF 859
Cdd:TIGR01652  802 VMASDFAIG--QFRFLTKLLLVhGRWSYKRISKMILYFFYKNLIFAIIQF 849
P-type_ATPase_cation cd07542
P-type cation-transporting ATPases, similar to human ATPase type 13A2 (ATP13A2) protein and ...
153-936 2.19e-32

P-type cation-transporting ATPases, similar to human ATPase type 13A2 (ATP13A2) protein and Saccharomyces cerevisiae Ypk9p; Saccharomyces cerevisiae Yph9p localizes to the yeast vacuole and may play a role in sequestering heavy metal ions, its deletion confers sensitivity for growth for cadmium, manganese, nickel or selenium. Human ATP13A2 (PARK9/CLN12) is a lysosomal transporter with zinc as the possible substrate. Mutation in the ATP13A2 gene has been linked to Parkinson's disease and Kufor-Rakeb syndrome, and to neuronal ceroid lipofuscinoses. ATP13A3/AFURS1 is a candidate gene for oculo auriculo vertebral spectrum (OAVS), being one of nine genes included in a 3q29 microduplication in a patient with OAVS. Mutation in the human ATP13A4 may be involved in a speech-language disorder. This subfamily also includes zebrafish ATP13A2 a lysosome-specific transmembrane ATPase protein of unknown function which plays a crucial role during embryonic development, its deletion is lethal. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319842 [Multi-domain]  Cd Length: 760  Bit Score: 135.84  E-value: 2.19e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  153 AAILASVIIVVFVTAFNdwsKEKQFRGLQSRIELEQKFSIIRNGQLIQLPVAEIVVGDIAQVKY-GDLLPADGILIQGND 231
Cdd:cd07542   55 ACIVIISVISIFLSLYE---TRKQSKRLREMVHFTCPVRVIRDGEWQTISSSELVPGDILVIPDnGTLLPCDAILLSGSC 131
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  232 LkIDESSLTGESDHVKKTLDKDP-----------------MLLSGTHVME--GSGRMVVTAVGInsQTGIIfTLLGanee 292
Cdd:cd07542  132 I-VNESMLTGESVPVTKTPLPDEsndslwsiysiedhskhTLFCGTKVIQtrAYEGKPVLAVVV--RTGFN-TTKG---- 203
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  293 eddekkkkgkkQGVsenRNkaktqdgvALEIQPLNSQEGLDSeekekkaskgpkkeksvlqgkLTRLAVQIGKAGLIMsI 372
Cdd:cd07542  204 -----------QLV---RS--------ILYPKPVDFKFYRDS---------------------MKFILFLAIIALIGF-I 239
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  373 LTVLILILYFVVDNFVIQRrawlpectpvyiqyfvkffiiGVTVLVVAVPEGLPLAVTISLAYSVKKmmkdnnLVRHLDA 452
Cdd:cd07542  240 YTLIILILNGESLGEIIIR---------------------ALDIITIVVPPALPAALTVGIIYAQSR------LKKKGIF 292
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  453 C---ETMGNATAI---CSDKTGTLTMNRMTVVQAYIGGTHYRQIPKPDDLPPNVLDLIVNSICINSAYTSKILppekegg 526
Cdd:cd07542  293 CispQRINICGKInlvCFDKTGTLTEDGLDLWGVRPVSGNNFGDLEVFSLDLDLDSSLPNGPLLRAMATCHSL------- 365
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  527 lpRQVGNKtecgLLGFVTDLKQdYQAVRSEMpeeKLFKVYTFNSVRKSMSTVIRKP-EGGFRVFSKGASEIMLRKCdril 605
Cdd:cd07542  366 --TLIDGE----LVGDPLDLKM-FEFTGWSL---EILRQFPFSSALQRMSVIVKTPgDDSMMAFTKGAPEMIASLC---- 431
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  606 NKEGgiVPfktkdrdNMVRNVIEPMASEGLRTIGIAYRDFDGEEPSWEN------ENE-IFTGLVCIavvgiEDPVRPEV 678
Cdd:cd07542  432 KPET--VP-------SNFQEVLNEYTKQGFRVIALAYKALESKTWLLQKlsreevESDlEFLGLIVM-----ENRLKPET 497
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  679 PDAINKCKRAGITVRMVTGDNVNTARAIATKCGILTPGddflclegkefNRLIRNEKGEVEQEKLDKVW----PRLRVLA 754
Cdd:cd07542  498 APVINELNRANIRTVMVTGDNLLTAISVARECGMISPS-----------KKVILIEAVKPEDDDSASLTwtllLKGTVFA 566
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  755 RSSPTDKHTLVKGIidSNIGeqrQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAkeASdiiltddnFTSIVKAVmwgR 834
Cdd:cd07542  567 RMSPDQKSELVEEL--QKLD---YTVGMCGDGANDCGALKAADVGISLSEAEASVA--AP--------FTSKVPDI---S 628
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  835 NVYDSISK--------FLQFQLTvnVVAVIVAFSGACI--TQDSPLKAVQMLWVNLIMDTFASLALATEPPTDSLLRRRP 904
Cdd:cd07542  629 CVPTVIKEgraalvtsFSCFKYM--ALYSLIQFISVLIlySINSNLGDFQFLFIDLVIITPIAVFMSRTGAYPKLSSKRP 706
                        810       820       830
                 ....*....|....*....|....*....|..
gi 54312088  905 YGRnkpLISRTMMKNILGHAVYQLGIVFLLVF 936
Cdd:cd07542  707 PAS---LVSPPVLVSLLGQIVLILLFQVIGFL 735
E1-E2_ATPase pfam00122
E1-E2 ATPase;
193-442 2.71e-32

E1-E2 ATPase;


Pssm-ID: 425475 [Multi-domain]  Cd Length: 181  Bit Score: 124.22  E-value: 2.71e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    193 IRNGQLIQLPVAEIVVGDIAQVKYGDLLPADGILIQGNDLkIDESSLTGESDHVKKtlDKDPMLLSGTHVMEGSGRMVVT 272
Cdd:pfam00122   10 LRDGTEEEVPADELVPGDIVLLKPGERVPADGRIVEGSAS-VDESLLTGESLPVEK--KKGDMVYSGTVVVSGSAKAVVT 86
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    273 AVGINSQTGIIFTLLganeeeddekkkkgkkqgvsenrnkaktqdgvaleiqplnsqegldseekekkasKGPKKEKSVL 352
Cdd:pfam00122   87 ATGEDTELGRIARLV-------------------------------------------------------EEAKSKKTPL 111
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    353 QGKLTRLAVQIGKAGLIMSILTVLILILYFVVDNFVIQRrawlpectpvyiqyfvkffiiGVTVLVVAVPEGLPLAVTIS 432
Cdd:pfam00122  112 QRLLDRLGKYFSPVVLLIALAVFLLWLFVGGPPLRALLR---------------------ALAVLVAACPCALPLATPLA 170
                          250
                   ....*....|
gi 54312088    433 LAYSVKKMMK 442
Cdd:pfam00122  171 LAVGARRLAK 180
P-type_ATPase_HM_ZosA_PfeT-like cd07551
P-type heavy metal-transporting ATPase, similar to Bacillus subtilis ZosA/PfeT which ...
149-861 2.80e-31

P-type heavy metal-transporting ATPase, similar to Bacillus subtilis ZosA/PfeT which transports copper, and perhaps zinc under oxidative stress, and perhaps ferrous iron; Bacillus subtilis ZosA/PfeT (previously known as YkvW) transports copper, it may also transport zinc under oxidative stress and may also be involved in ferrous iron efflux. ZosA/PfeT is expressed under the regulation of the peroxide-sensing repressor PerR. It is involved in competence development. Disruption of the zosA/pfeT gene results in low transformability. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319849 [Multi-domain]  Cd Length: 611  Bit Score: 131.22  E-value: 2.80e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  149 WIEGAailasVIIVVFVT--AFNDWSKEKQFRGLQSRIEL--EQKFSIIRNGQLIQLPVAEIVVGDIAQVKYGDLLPADG 224
Cdd:cd07551   75 WAEGA-----LLIFIFSLshALEDYAMGRSKRAITALMQLapETARRIQRDGEIEEVPVEELQIGDRVQVRPGERVPADG 149
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  225 ILIQGNDlKIDESSLTGESDHVKKTLDKDpmLLSGTHVMEGSGRMVVTavginsqtgiiftllganeeeddekkkkgkkq 304
Cdd:cd07551  150 VILSGSS-SIDEASITGESIPVEKTPGDE--VFAGTINGSGALTVRVT-------------------------------- 194
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  305 gvsenrnKAKTQDGVALEIQPLNSQEgldsEEKEKKASKGPKKEKsvlqgkltrlavqigkaglIMSILTVLILILYFVV 384
Cdd:cd07551  195 -------KLSSDTVFAKIVQLVEEAQ----SEKSPTQSFIERFER-------------------IYVKGVLLAVLLLLLL 244
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  385 DNFVIQRrAWLPEctpvyiqyfvkfFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICS 464
Cdd:cd07551  245 PPFLLGW-TWADS------------FYRAMVFLVVASPCALVASTPPATLSAIANAARQGVLFKGGVHLENLGSVKAIAF 311
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  465 DKTGTLTMNRMTVVQA-YIGGTHYRQ-------IPKPDDLPpnvldlIVNSICINSAYTSKILPPEKEgglprqVGNKTE 536
Cdd:cd07551  312 DKTGTLTEGKPRVTDViPAEGVDEEEllqvaaaAESQSEHP------LAQAIVRYAEERGIPRLPAIE------VEAVTG 379
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  537 CGLLGFVtdlkqDYQAVRsempeeklfkvytfnsvrksmstvIRKPegGFrvfskgaseimlrkcdrilnkeggivpFKT 616
Cdd:cd07551  380 KGVTATV-----DGQTYR------------------------IGKP--GF---------------------------FGE 401
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  617 KDRDNMVRNVIEPMASEGlRTIGIAYRDfdgEEPsweneneiftglvcIAVVGIEDPVRPEVPDAINKCKRAGITVRMVT 696
Cdd:cd07551  402 VGIPSEAAALAAELESEG-KTVVYVARD---DQV--------------VGLIALMDTPRPEAKEAIAALRLGGIKTIMLT 463
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  697 GDNVNTARAIATKCGIltpgddflclegkefnrlirnekgeveqeklDKVWprlrvlARSSPTDKHTLVKgiidsNIGEQ 776
Cdd:cd07551  464 GDNERTAEAVAKELGI-------------------------------DEVV------ANLLPEDKVAIIR-----ELQQE 501
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  777 RQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVI 856
Cdd:cd07551  502 YGTVAMVGDGINDAPALANADVGIAMG-AGTDVALETADVVLMKDDLSKLPYAIRLSRKMRRIIKQNLIFALAVIALLIV 580

                 ....*
gi 54312088  857 VAFSG 861
Cdd:cd07551  581 ANLFG 585
P-type_ATPase_HM cd07550
P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily ...
192-861 8.37e-31

P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily of the heavy metal-transporting ATPases (Type IB ATPases) which transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319848 [Multi-domain]  Cd Length: 592  Bit Score: 129.32  E-value: 8.37e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  192 IIRNGQLIQLPVAEIVVGDIAQVKYGDLLPADGILIQGNDLkIDESSLTGESDHVKKTldKDPMLLSGTHVMEGSGRMVV 271
Cdd:cd07550  104 VERDGVEVEVPADEVQPGDTVVVGAGDVIPVDGTVLSGEAL-IDQASLTGESLPVEKR--EGDLVFASTVVEEGQLVIRA 180
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  272 TAVGINSQTGIIftllganeeeddekkkkgkkqgvsenrnkaktqdgvaleIQPLNSQEGLDSEekekkaskgpkkeksv 351
Cdd:cd07550  181 ERVGRETRAARI---------------------------------------AELIEQSPSLKAR---------------- 205
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  352 LQGKLTRLAVQIgkaglimsILTVLIL--ILYFVVDNFviqRRAwlpectpvyiqyfvkffiigVTVLVV----AVPEGL 425
Cdd:cd07550  206 IQNYAERLADRL--------VPPTLGLagLVYALTGDI---SRA--------------------AAVLLVdfscGIRLST 254
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  426 PLAVTISLAYSVKKMMkdnnLVRHLDACETMGNATAICSDKTGTLTMNRMTVVQAyiggthyrqIPKPDDLPPNVLdliv 505
Cdd:cd07550  255 PVAVLSALNHAARHGI----LVKGGRALELLAKVDTVVFDKTGTLTEGEPEVTAI---------ITFDGRLSEEDL---- 317
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  506 nsICINSAYTSKILPPekeggLPRQVGNKTEC-GLLGFVTDlKQDYQavrsempeeklfkvytfnsVRKSMSTVIRKPEg 584
Cdd:cd07550  318 --LYLAASAEEHFPHP-----VARAIVREAEErGIEHPEHE-EVEYI-------------------VGHGIASTVDGKR- 369
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  585 gFRVFSkgaseimlrkcDRILNKEGGIVPFKTKDRdnmvrnvIEPMASEGLRTIGIAyrdFDGEepsweneneiftglvC 664
Cdd:cd07550  370 -IRVGS-----------RHFMEEEEIILIPEVDEL-------IEDLHAEGKSLLYVA---IDGR---------------L 412
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  665 IAVVGIEDPVRPEVPDAINKCKRAG-ITVRMVTGDNVNTARAIATKCGIltpgddflclegkefnrlirnekGEVEQEKL 743
Cdd:cd07550  413 IGVIGLSDPLRPEAAEVIARLRALGgKRIIMLTGDHEQRARALAEQLGI-----------------------DRYHAEAL 469
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  744 dkvwprlrvlarssPTDKHTLVKGIidsnigeQRQ--VVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDD 821
Cdd:cd07550  470 --------------PEDKAEIVEKL-------QAEgrTVAFVGDGINDSPALSYADVGISMR-GGTDIARETADVVLLED 527
                        650       660       670       680
                 ....*....|....*....|....*....|....*....|
gi 54312088  822 NFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFSG 861
Cdd:cd07550  528 DLRGLAEAIELARETMALIKRNIALVVGPNTAVLAGGVFG 567
P-type_ATPase_Cd-like cd07545
P-type heavy metal-transporting ATPase, similar to Staphylococcus aureus plasmid pI258 CadA, a ...
147-888 1.34e-29

P-type heavy metal-transporting ATPase, similar to Staphylococcus aureus plasmid pI258 CadA, a cadmium-efflux ATPase; CadA from gram-positive Staphylococcus aureus plasmid pI258 is required for full Cd(2+) and Zn(2+) resistance. This subfamily also includes CadA, from the gram-negative bacilli, Stenotrophomonas maltophilia D457R, which is a cadmium efflux pump acquired as part of a cluster of antibiotic and heavy metal resistance genes from gram-positive bacteria. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319845 [Multi-domain]  Cd Length: 599  Bit Score: 125.61  E-value: 1.34e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  147 TGWIEGAAIL-----ASVIIVVFVT--AFNDWSKEKQFRGLQSRIELEQKFSII-RNGQLIQLPVAEIVVGDIAQVKYGD 218
Cdd:cd07545   47 TIAVIGAALIgewpeAAMVVFLFAIseALEAYSMDRARRSIRSLMDIAPKTALVrRDGQEREVPVAEVAVGDRMIVRPGE 126
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  219 LLPADGILIQGNDLkIDESSLTGESDHVKKTLDKDpmLLSGTHVMEGSGRMVVTAVGINSQTGIIFTLLganeeeddekk 298
Cdd:cd07545  127 RIAMDGIIVRGESS-VNQAAITGESLPVEKGVGDE--VFAGTLNGEGALEVRVTKPAEDSTIARIIHLV----------- 192
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  299 kkgkkqgvsenrnkaktqdgvaleiqplnsqegldseeKEKKASKGPKkeksvlQGKLTRLAVQIGKAGLIMSILTVLIL 378
Cdd:cd07545  193 --------------------------------------EEAQAERAPT------QAFVDRFARYYTPVVMAIAALVAIVP 228
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  379 ILYFVvdnfviqrRAWLpecTPVYIqyfvkffiiGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGN 458
Cdd:cd07545  229 PLFFG--------GAWF---TWIYR---------GLALLVVACPCALVISTPVSIVSAIGNAARKGVLIKGGVYLEELGR 288
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  459 ATAICSDKTGTLTMNRMTVVQAY-IGGTHYRQipkpddlppnvLDLIVNSICINSAY--TSKILPPEKEGGLP----RQV 531
Cdd:cd07545  289 LKTVAFDKTGTLTKGKPVVTDVVvLGGQTEKE-----------LLAIAAALEYRSEHplASAIVKKAEQRGLTlsavEEF 357
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  532 GNKTECGLLGFVTDlkqdyqavrsempeeklfKVYTFnsvrksmstvirkpeGGFRVFS-KGASEImlrkcdrilnkegg 610
Cdd:cd07545  358 TALTGRGVRGVVNG------------------TTYYI---------------GSPRLFEeLNLSES-------------- 390
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  611 iVPFKTKdrdnmvrnvIEPMASEGLRTIGIAyrdfDGEEPsweneneiftglvcIAVVGIEDPVRPEVPDAINKCKRAGI 690
Cdd:cd07545  391 -PALEAK---------LDALQNQGKTVMILG----DGERI--------------LGVIAVADQVRPSSRNAIAALHQLGI 442
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  691 --TVrMVTGDNVNTARAIATKCGIltpgddflclegkefnrlirnekGEVEQEKLdkvwprlrvlarssPTDKHTLVKGI 768
Cdd:cd07545  443 kqTV-MLTGDNPQTAQAIAAQVGV-----------------------SDIRAELL--------------PQDKLDAIEAL 484
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  769 IdsnigEQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQL 848
Cdd:cd07545  485 Q-----AEGGRVAMVGDGVNDAPALAAADVGIAMGAAGTDTALETADIALMGDDLRKLPFAVRLSRKTLAIIKQNIAFAL 559
                        730       740       750       760
                 ....*....|....*....|....*....|....*....|
gi 54312088  849 TVNVVAVIVAFSGacitqdsplkaVQMLWVNLIMDTFASL 888
Cdd:cd07545  560 GIKLIALLLVIPG-----------WLTLWMAVFADMGASL 588
P-type_ATPase_HM cd07544
P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily ...
156-830 4.09e-27

P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily of the heavy metal-transporting ATPases (Type IB ATPases) which transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319844 [Multi-domain]  Cd Length: 596  Bit Score: 118.19  E-value: 4.09e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  156 LASVIIVVFVT---AFNDWSKEKQFRGLQSRIE-LEQKFSIIRNGQLIQLPVAEIVVGDIAQVKYGDLLPADGILIQGND 231
Cdd:cd07544   74 WASLIILLMLTggeALEDYAQRRASRELTALLDrAPRIAHRLVGGQLEEVPVEEVTVGDRLLVRPGEVVPVDGEVVSGTA 153
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  232 LkIDESSLTGESDHVKKTLDKDpmLLSGTHVMEGSGRMVVTAVGINSQTGIIFTLLganeeeddekkkkgkkqgvsenrn 311
Cdd:cd07544  154 T-LDESSLTGESKPVSKRPGDR--VMSGAVNGDSALTMVATKLAADSQYAGIVRLV------------------------ 206
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  312 kaktqdgvaleiqplnsqegldseeKEKKASKGPkkeksvlqgkLTRLAVQIGKAGLIMSILTVLIlilyfvvdnfviqr 391
Cdd:cd07544  207 -------------------------KEAQANPAP----------FVRLADRYAVPFTLLALAIAGV-------------- 237
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  392 rAWLPECTPVYIqyfvkffiigVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLT 471
Cdd:cd07544  238 -AWAVSGDPVRF----------AAVLVVATPCPLILAAPVAIVSGMSRSSRRGILVKDGGVLEKLARAKTVAFDKTGTLT 306
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  472 MNRMTVVQayiggthyrQIPKPDDLPPNVLDLI---------VNSICINSAYTSKILPPEKegglPRQVGNKTECGLLGF 542
Cdd:cd07544  307 YGQPKVVD---------VVPAPGVDADEVLRLAasveqysshVLARAIVAAARERELQLSA----VTELTEVPGAGVTGT 373
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  543 VtdlkqdyqavrsempEEKLFKVYTFNSVRKsmstvirKPEGGFRVFSKgaseimlrkcdrilnkeggivpfktkdrdnm 622
Cdd:cd07544  374 V---------------DGHEVKVGKLKFVLA-------RGAWAPDIRNR------------------------------- 400
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  623 vrnviepmaseglrtigiayrdFDGEEPSWENENEIFTGLVCIAvvgieDPVRPEVPDAINKCKRAGIT-VRMVTGDNVN 701
Cdd:cd07544  401 ----------------------PLGGTAVYVSVDGKYAGAITLR-----DEVRPEAKETLAHLRKAGVErLVMLTGDRRS 453
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  702 TARAIATKCGIltpgDDflclegkefnrlirnekgeveqekldkvwprlrVLARSSPTDKHTLVKGIidsnigEQRQVVA 781
Cdd:cd07544  454 VAEYIASEVGI----DE---------------------------------VRAELLPEDKLAAVKEA------PKAGPTI 490
                        650       660       670       680
                 ....*....|....*....|....*....|....*....|....*....
gi 54312088  782 VTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAV 830
Cdd:cd07544  491 MVGDGVNDAPALAAADVGIAMGARGSTAASEAADVVILVDDLDRVVDAV 539
P-type_ATPase_cation cd02082
P-type cation-transporting ATPases, similar to human ATPase type 13A1-A4 (ATP13A1-A4) proteins ...
160-810 4.10e-25

P-type cation-transporting ATPases, similar to human ATPase type 13A1-A4 (ATP13A1-A4) proteins and Saccharomyces cerevisiae Ypk9p and Spf1p; Saccharomyces cerevisiae Yph9p localizes to the yeast vacuole and may play a role in sequestering heavy metal ions, its deletion confers sensitivity for growth for cadmium, manganese, nickel or selenium. Saccharomyces 1 Spf1p may mediate manganese transport into the endoplasmic reticulum. Human ATP13A2 (PARK9/CLN12) is a lysosomal transporter with zinc as the possible substrate. Mutation in the ATP13A2 gene has been linked to Parkinson's disease and Kufor-Rakeb syndrome, and to neuronal ceroid lipofuscinoses. ATP13A3/AFURS1 is a candidate gene for oculo auriculo vertebral spectrum (OAVS), being one of nine genes included in a 3q29 microduplication in a patient with OAVS. Mutation in the human ATP13A4 may be involved in a speech-language disorder. The expression of ATP13A1 has been followed during mouse development, ATP13A1 transcript expression showed an increase as development progressed, with the highest expression at the peak of neurogenesis. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319777 [Multi-domain]  Cd Length: 786  Bit Score: 112.68  E-value: 4.10e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  160 IIVVFVTAFNDWSKEKQFRGLQSRIEL----EQKFSIIRNG-QLIQLPVAEIVVGDIAQVKY-GDLLPADGILIQGNdLK 233
Cdd:cd02082   54 ITVVFMTTINSLSCIYIRGVMQKELKDaclnNTSVIVQRHGyQEITIASNMIVPGDIVLIKRrEVTLPCDCVLLEGS-CI 132
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  234 IDESSLTGESDHVKKTLDKDPMLLSGTHVMEGSGRMVvtavginsqtgiIFtllganeeeddekkkkgkkQGVSENRNKA 313
Cdd:cd02082  133 VTEAMLTGESVPIGKCQIPTDSHDDVLFKYESSKSHT------------LF-------------------QGTQVMQIIP 181
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  314 KTQDGVALEIqplnSQEGLDSeekekkaSKGpKKEKSVLQGKLTRLAVQIGKAGLIMSILTVLILILYFVVDNFViqrra 393
Cdd:cd02082  182 PEDDILKAIV----VRTGFGT-------SKG-QLIRAILYPKPFNKKFQQQAVKFTLLLATLALIGFLYTLIRLL----- 244
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  394 wLPECTPVYIqyFVKFFIIgvtvLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTMN 473
Cdd:cd02082  245 -DIELPPLFI--AFEFLDI----LTYSVPPGLPMLIAITNFVGLKRLKKNQILCQDPNRISQAGRIQTLCFDKTGTLTED 317
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  474 RMtVVQAYIGGTHYRQIPKPDDLPPNVLDLIVNSICINSAYTsKIlppekEGGLprqVGNKTECGLLGFVT-DLKQDYQA 552
Cdd:cd02082  318 KL-DLIGYQLKGQNQTFDPIQCQDPNNISIEHKLFAICHSLT-KI-----NGKL---LGDPLDVKMAEASTwDLDYDHEA 387
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  553 vrSEMPEE------KLFKVYTFNSVRKSMSTVIRKPEGGFR-----VFSKGASEIMLRKCDRILNKEggivpfktkdrdn 621
Cdd:cd02082  388 --KQHYSKsgtkrfYIIQVFQFHSALQRMSVVAKEVDMITKdfkhyAFIKGAPEKIQSLFSHVPSDE------------- 452
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  622 mvRNVIEPMASEGLRTIGIAYRDFdGEEPSWENEN----EIFTGLVCIAVVGIEDPVRPEVPDAINKCKRAGITVRMVTG 697
Cdd:cd02082  453 --KAQLSTLINEGYRVLALGYKEL-PQSEIDAFLDlsreAQEANVQFLGFIIYKNNLKPDTQAVIKEFKEACYRIVMITG 529
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  698 DNVNTARAIATKCGILTPGDDFLCLEgkefnrLIRNEKGEVEQEKLdKVWPRLRVLARSSPTDKHTLVKGIIDSNigeqr 777
Cdd:cd02082  530 DNPLTALKVAQELEIINRKNPTIIIH------LLIPEIQKDNSTQW-ILIIHTNVFARTAPEQKQTIIRLLKESD----- 597
                        650       660       670
                 ....*....|....*....|....*....|...
gi 54312088  778 QVVAVTGDGTNDGPALKKADVGFAMGIAGTDVA 810
Cdd:cd02082  598 YIVCMCGDGANDCGALKEADVGISLAEADASFA 630
P-type_ATPase_APLT cd07536
Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, ...
153-857 1.20e-23

Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, Neo1p, and human ATP8A2, -9B, -10D, -11B, and -11C; Aminophospholipid translocases (APLTs), also known as type 4 P-type ATPases, act as flippases, and translocate specific phospholipids from the exoplasmic leaflet to the cytoplasmic leaflet of biological membranes. Yeast Dnf1 and Dnf2 mediate the transport of phosphatidylethanolamine, phosphatidylserine, and phosphatidylcholine from the outer to the inner leaflet of the plasma membrane. Mammalian ATP11C may selectively transports PS and PE from the outer leaflet of the plasma membrane to the inner leaflet. The yeast Neo1p localizes to the endoplasmic reticulum and the Golgi complex and plays a role in membrane trafficking within the endomembrane system. Human putative ATPase phospholipid transporting 9B, ATP9B, localizes to the trans-golgi network in a CDC50 protein-independent manner. It also includes Arabidopsis phospholipid flippases including ALA1, and Caenorhabditis elegans flippases, including TAT-1, the latter has been shown to facilitate the inward transport of phosphatidylserine. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319838 [Multi-domain]  Cd Length: 805  Bit Score: 108.07  E-value: 1.20e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  153 AAILASVIIVVFVTAfndwSKE--KQFRGLQSRIEL-EQKFSIIRNGQLIQLPVAEIVVGDIAQVKYGDLLPADGILIQG 229
Cdd:cd07536   49 YTTWAPLIFILAVTM----TKEaiDDFRRFQRDKEVnKKQLYSKLTGRKVQIKSSDIQVGDIVIVEKNQRIPSDMVLLRT 124
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  230 NDLK----IDESSLTGESD-HVKKTLDKDPMLLSGTHVMEGSGRMV--VTAVGINSQTGIiFTLLGANEEEDDEKKKKGK 302
Cdd:cd07536  125 SEPQgscyVETAQLDGETDlKLRVAVSCTQQLPALGDLMKISAYVEcqKPQMDIHSFEGN-FTLEDSDPPIHESLSIENT 203
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  303 KQGVSENRNkakTQDGVALEIQPLNsqegldsEEKEKKASKGPKKEKSVLQGKLTRLAVQIGKAGLIMSIltVLILILYF 382
Cdd:cd07536  204 LLRASTLRN---TGWVIGVVVYTGK-------ETKLVMNTSNAKNKVGLLDLELNRLTKALFLALVVLSL--VMVTLQGF 271
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  383 VVDNFVIQRRAWLPECTPVYIQYFVKF-FIIGVTVLVvavpeglPLAVTISL----AYSVKKMMKDNNL----------V 447
Cdd:cd07536  272 WGPWYGEKNWYIKKMDTTSDNFGRNLLrFLLLFSYII-------PISLRVNLdmvkAVYAWFIMWDENMyyigndtgtvA 344
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  448 RHLDACETMGNATAICSDKTGTLTMNRMTVVQAYIGGTHYrqipkpddlppnvldlivnsicinsaytskilppekeGGl 527
Cdd:cd07536  345 RTSTIPEELGQVVYLLTDKTGTLTQNEMIFKRCHIGGVSY-------------------------------------GG- 386
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  528 prqvgnktecgllgfvtdlkqdyQAVRSEmpeekLFKVYTFNSVRKSMSTVIRKPEGG-FRVFSKGASEIMLrkcdriln 606
Cdd:cd07536  387 -----------------------QVLSFC-----ILQLLEFTSDRKRMSVIVRDESTGeITLYMKGADVAIS-------- 430
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  607 keggivPFKTKDRDNMVRN-VIEPMASEGLRTIGIAYRDFDGEE-PSWENE-------------------NEIFTGLVCI 665
Cdd:cd07536  431 ------PIVSKDSYMEQYNdWLEEECGEGLRTLCVAKKALTENEyQEWESRyteaslslhdrslrvaevvESLERELELL 504
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  666 AVVGIEDPVRPEVPDAINKCKRAGITVRMVTGDNVNTARAIATKCGILTPGDDFLCL--EGKEFNR--------LIRNEK 735
Cdd:cd07536  505 GLTAIEDRLQAGVPETIETLRKAGIKIWMLTGDKQETAICIAKSCHLVSRTQDIHLLrqDTSRGERaaitqhahLELNAF 584
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  736 GE-------------------VEQEKLD-KVWPRLRVLARSSPTDKHTLVKgIIDSNIGeqRQVVAVtGDGTNDGPALKK 795
Cdd:cd07536  585 RRkhdvalvidgdslevalkyYRHEFVElACQCPAVICCRVSPTQKARIVT-LLKQHTG--RRTLAI-GDGGNDVSMIQA 660
                        730       740       750       760       770       780
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 54312088  796 ADVGfaMGIAGTD--VAKEASDIILTddNFTSIVKAVM-WGRNVYDSISKFLQFQLTVNVVAVIV 857
Cdd:cd07536  661 ADCG--VGISGKEgkQASLAADYSIT--QFRHLGRLLLvHGRNSYNRSAALGQYVFYKGLIISTI 721
P-type_ATPase_Pb_Zn_Cd2-like cd07546
P-type heavy metal-transporting ATPase, similar to Escherichia coli ZntA which is selective ...
152-903 3.78e-22

P-type heavy metal-transporting ATPase, similar to Escherichia coli ZntA which is selective for Pb(2+), Zn(2+), and Cd(2+); Escherichia coli ZntA mediates resistance to toxic levels of selected divalent metal ions. ZntA has the highest selectivity for Pb(2+), followed by Zn(2+) and Cd(2+); it also shows low levels of activity with Cu(2+), Ni(2+), and Co(2+). It is upregulated by the transcription factor ZntR at high zinc concentrations. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319846 [Multi-domain]  Cd Length: 597  Bit Score: 102.48  E-value: 3.78e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  152 GAAILASVIIVVFVT--AFNDWSKEKQFRGLQSRIELEQKFSI-IRNGQLIQLPVAEIVVGDIAQVKYGDLLPADGILIQ 228
Cdd:cd07546   60 GATAEAAMVLLLFLVgeLLEGYAASRARSGVKALMALVPETALrEENGERREVPADSLRPGDVIEVAPGGRLPADGELLS 139
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  229 GNDlKIDESSLTGESDHVKKTldKDPMLLSGTHVMEGSGRMVVTAVGINSQTGIIFTLLganeeeddekkkkgkkqgvse 308
Cdd:cd07546  140 GFA-SFDESALTGESIPVEKA--AGDKVFAGSINVDGVLRIRVTSAPGDNAIDRILHLI--------------------- 195
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  309 nrnkaktqdgvaleiqplnsqegldsEEKEKkaSKGPkkeksvLQGKLTRLAVQIGKAGLIMSILTVLILILYFVVDnfv 388
Cdd:cd07546  196 --------------------------EEAEE--RRAP------IERFIDRFSRWYTPAIMAVALLVIVVPPLLFGAD--- 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  389 iqrraWLpecTPVYIqyfvkffiiGVTVLVVAVPEGL----PLAVTISLAYSVKKMMkdnnLVRHLDACETMGNATAICS 464
Cdd:cd07546  239 -----WQ---TWIYR---------GLALLLIGCPCALvistPAAITSGLAAAARRGA----LIKGGAALEQLGRVTTVAF 297
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  465 DKTGTLTMNRmtvvqayiggthyrqipkpddlpPNVLDLivnsicinsaytskilppekeggLPRQVGNKTEcgLLGfvt 544
Cdd:cd07546  298 DKTGTLTRGK-----------------------PVVTDV-----------------------VPLTGISEAE--LLA--- 326
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  545 dlkqdyQAVRSEMPEEKLFKVYTFNSVRKSMSTVIRKPEGGFRVfSKGASEIMLRKCDRILNKEggivpFKTKDRDNMVR 624
Cdd:cd07546  327 ------LAAAVEMGSSHPLAQAIVARAQAAGLTIPPAEEARALV-GRGIEGQVDGERVLIGAPK-----FAADRGTLEVQ 394
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  625 NVIEPMASEGlRTIGIAyrdFDGEEPSweneneiftglvciAVVGIEDPVRPEVPDAINKCKRAGITVRMVTGDNVNTAR 704
Cdd:cd07546  395 GRIAALEQAG-KTVVVV---LANGRVL--------------GLIALRDELRPDAAEAVAELNALGIKALMLTGDNPRAAA 456
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  705 AIATKCGIltpgddflclegkefnrlirnekgEVEQEKLdkvwprlrvlarssPTDKhtlVKGIIDSNigeQRQVVAVTG 784
Cdd:cd07546  457 AIAAELGL------------------------DFRAGLL--------------PEDK---VKAVRELA---QHGPVAMVG 492
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  785 DGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFSGacI 864
Cdd:cd07546  493 DGINDAPAMKAASIGIAMG-SGTDVALETADAALTHNRLGGVAAMIELSRATLANIRQNITIALGLKAVFLVTTLLG--I 569
                        730       740       750
                 ....*....|....*....|....*....|....*....
gi 54312088  865 TQdsplkavqmLWVNLIMDTFASlALATEPPTdSLLRRR 903
Cdd:cd07546  570 TG---------LWLAVLADTGAT-VLVTANAL-RLLRFR 597
P-type_ATPase_cation cd07543
P-type cation-transporting ATPases, similar to human cation-transporting ATPase type 13A1 ...
192-802 1.02e-19

P-type cation-transporting ATPases, similar to human cation-transporting ATPase type 13A1 (ATP13A1) and Saccharomyces manganese-transporting ATPase 1 Spf1p; Saccharomyces Spf1p may mediate manganese transport into the endoplasmic reticulum (ER); one consequence of deletion of SPF1 is severe ER stress. This subfamily also includes Arabidopsis thaliana MIA (Male Gametogenesis Impaired Anthers) protein which is highly abundant in the endoplasmic reticulum and small vesicles of developing pollen grains and tapetum cells. The MIA gene functionally complements a mutant in the SPF1 from Saccharomyces cerevisiae. The expression of ATP13A1 has been followed during mouse development, ATP13A1 transcript expression showed an increase as development progressed, with the highest expression at the peak of neurogenesis. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319843 [Multi-domain]  Cd Length: 804  Bit Score: 95.53  E-value: 1.02e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  192 IIRNGQLIQLPVAEIVVGDIAQVKYG---DLLPADGILIQGNDLkIDESSLTGES-DHVK---KTLDKDPMLLSGT---- 260
Cdd:cd07543   90 VYRDGKWVPISSDELLPGDLVSIGRSaedNLVPCDLLLLRGSCI-VNEAMLTGESvPLMKepiEDRDPEDVLDDDGddkl 168
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  261 HVMEGSGRMVvtavginsqtgiiftllganeeeddekkkkgkkQGVSENRNKAKTQDGVALEIQplnSQEGLDSEekekk 340
Cdd:cd07543  169 HVLFGGTKVV---------------------------------QHTPPGKGGLKPPDGGCLAYV---LRTGFETS----- 207
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  341 askgpkkeksvlQGKLTRLAVqIGKAGLIMSILTVLILILYFVVdnFVIQRRAWlpectpVYIQ------YFVKFFIIGV 414
Cdd:cd07543  208 ------------QGKLLRTIL-FSTERVTANNLETFIFILFLLV--FAIAAAAY------VWIEgtkdgrSRYKLFLECT 266
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  415 TVLVVAVPEGLP----LAVTISLAYSVKKMMKDNNLVR-----HLDACetmgnataiCSDKTGTLTMNRMtVVQAYIGGT 485
Cdd:cd07543  267 LILTSVVPPELPmelsLAVNTSLIALAKLYIFCTEPFRipfagKVDIC---------CFDKTGTLTSDDL-VVEGVAGLN 336
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  486 HYRQ-IPKPDDLPPNVLDLIVnsiCINSaytskiLPPEKEGGLprqVGNKTECGLLGFV--TDLKQDYQAVRSE-MPEEK 561
Cdd:cd07543  337 DGKEvIPVSSIEPVETILVLA---SCHS------LVKLDDGKL---VGDPLEKATLEAVdwTLTKDEKVFPRSKkTKGLK 404
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  562 LFKVYTFNSVRKSMSTV--IRKPEGG---FRVFSKGASEI---MLRKCdrilnkeggivpfkTKDRDNMVRNviepMASE 633
Cdd:cd07543  405 IIQRFHFSSALKRMSVVasYKDPGSTdlkYIVAVKGAPETlksMLSDV--------------PADYDEVYKE----YTRQ 466
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  634 GLRTIGIAYRDFDGEEPSWENE---NEIFTGLVCIAVVGIEDPVRPEVPDAINKCKRAGITVRMVTGDNVNTARAIATKC 710
Cdd:cd07543  467 GSRVLALGYKELGHLTKQQARDykrEDVESDLTFAGFIVFSCPLKPDSKETIKELNNSSHRVVMITGDNPLTACHVAKEL 546
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  711 GILTpgddflclegKEFNRLIRNEKGEVEQEKLdkvWPRLRVLARSSPTDKHTLVkgiidSNIGEQRQVVAVTGDGTNDG 790
Cdd:cd07543  547 GIVD----------KPVLILILSEEGKSNEWKL---IPHVKVFARVAPKQKEFII-----TTLKELGYVTLMCGDGTNDV 608
                        650
                 ....*....|..
gi 54312088  791 PALKKADVGFAM 802
Cdd:cd07543  609 GALKHAHVGVAL 620
Cation_ATPase pfam13246
Cation transport ATPase (P-type); This domain is found in cation transport ATPases, including ...
508-604 1.05e-19

Cation transport ATPase (P-type); This domain is found in cation transport ATPases, including phospholipid-transporting ATPases, calcium-transporting ATPases, and sodium-potassium ATPases.


Pssm-ID: 463817 [Multi-domain]  Cd Length: 91  Bit Score: 84.96  E-value: 1.05e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    508 ICINSAytskILPPEKEGGLPRQVGNKTECGLLGFVTDLKQDYQAVRSEMPeeKLFkVYTFNSVRKSMSTVIRKP-EGGF 586
Cdd:pfam13246    1 ALCNSA----AFDENEEKGKWEIVGDPTESALLVFAEKMGIDVEELRKDYP--RVA-EIPFNSDRKRMSTVHKLPdDGKY 73
                           90
                   ....*....|....*...
gi 54312088    587 RVFSKGASEIMLRKCDRI 604
Cdd:pfam13246   74 RLFVKGAPEIILDRCTTI 91
P-type_ATPase_K cd02078
potassium-transporting ATPase ATP-binding subunit, KdpB, a subunit of the prokaryotic ...
667-834 4.75e-19

potassium-transporting ATPase ATP-binding subunit, KdpB, a subunit of the prokaryotic high-affinity potassium uptake system KdpFABC; similar to Escherichia coli KdpB; KdpFABC is a prokaryotic high-affinity potassium uptake system. It is expressed under K(+) limiting conditions when the other potassium transport systems are not able to provide a sufficient flow of K(+) into the bacteria. The KdpB subunit represents the catalytic subunit performing ATP hydrolysis. KdpB is comprised of four domains: the transmembrane domain, the nucleotide-binding domain, the phosphorylation domain, and the actuator domain. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319773 [Multi-domain]  Cd Length: 667  Bit Score: 92.71  E-value: 4.75e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  667 VVGIEDPVRPEVPDAINKCKRAGITVRMVTGDNVNTARAIATKCGIltpgDDFLclegkefnrlirnekgeveqekldkv 746
Cdd:cd02078  430 VIYLKDIIKPGIKERFAELRKMGIKTVMITGDNPLTAAAIAAEAGV----DDFL-------------------------- 479
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  747 wprlrvlARSSPTDKHTLVKgiidsNIGEQRQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDDNFTSI 826
Cdd:cd02078  480 -------AEAKPEDKLELIR-----KEQAKGKLVAMTGDGTNDAPALAQADVGVAMN-SGTQAAKEAGNMVDLDSDPTKL 546

                 ....*...
gi 54312088  827 VKAVMWGR 834
Cdd:cd02078  547 IEVVEIGK 554
P-type_ATPase_APLT_Neo1-like cd07541
Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Neo1p and human ...
399-846 1.40e-16

Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Neo1p and human putative APLT, ATP9B; Aminophospholipid translocases (APLTs), also known as type 4 P-type ATPases, act as a flippases, and translocate specific phospholipids from the exoplasmic leaflet to the cytoplasmic leaflet of biological membranes. The yeast Neo1 gene is an essential gene; Neo1p localizes to the endoplasmic reticulum and the Golgi complex and plays a role in membrane trafficking within the endomembrane system. Also included in this sub family is human putative ATPase phospholipid transporting 9B, ATP9B, which localizes to the trans-golgi network in a CDC50 protein-independent manner. Levels of ATP9B, along with levels of other ATPase genes, may contribute to expressivity of and atypical presentations of Hailey-Hailey disease (HHD), and the ATP9B gene has recently been identified as a putative Alzheimer's disease loci. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319841 [Multi-domain]  Cd Length: 792  Bit Score: 85.15  E-value: 1.40e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  399 TPVYIQYFvKFFIIGVTVLVVAvpeglpLAVTISLAYSV--KKMMKDNNL----VRHLDACETMGNATAICSDKTGTLTM 472
Cdd:cd07541  267 GPWYIYLF-RFLILFSSIIPIS------LRVNLDMAKIVysWQIEHDKNIpgtvVRTSTIPEELGRIEYLLSDKTGTLTQ 339
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  473 NRMTVVQAYIGGTHYRqipkpddlppnvldLIVNSICInsaytskilppekegglprqvgnktecgllgfvtdlkqdyqa 552
Cdd:cd07541  340 NEMVFKKLHLGTVSYG--------------GQNLNYEI------------------------------------------ 363
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  553 vrsempeeklFKVYTFNSVRKSMSTVIRKPE-GGFRVFSKGASEIM--LRKCDRILNKEGGivpfktkdrdNMVRnviep 629
Cdd:cd07541  364 ----------LQIFPFTSESKRMGIIVREEKtGEITFYMKGADVVMskIVQYNDWLEEECG----------NMAR----- 418
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  630 masEGLRTIGIA--------YRDFDGE----EPSWENENE--------IFTGLVCIAVVGIEDPVRPEVPDAINKCKRAG 689
Cdd:cd07541  419 ---EGLRTLVVAkkklseeeYQAFEKRynaaKLSIHDRDLkvaevvesLERELELLCLTGVEDKLQEDVKPTLELLRNAG 495
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  690 ITVRMVTGDNVNTARAIATKCGILTPGDDF-----LCLEGKEFNRL--IRNEK---------------GEVEQEKLDKVW 747
Cdd:cd07541  496 IKIWMLTGDKLETATCIAKSSKLVSRGQYIhvfrkVTTREEAHLELnnLRRKHdcalvidgeslevclKYYEHEFIELAC 575
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  748 PRLRVLA-RSSPTDKHTLVKGIIDSNigeQRQVVAVtGDGTNDGPALKKADVGfaMGIAGTDvAKEAS---DIILTDdnF 823
Cdd:cd07541  576 QLPAVVCcRCSPTQKAQIVRLIQKHT---GKRTCAI-GDGGNDVSMIQAADVG--VGIEGKE-GKQASlaaDFSITQ--F 646
                        490       500
                 ....*....|....*....|....
gi 54312088  824 TSIVKAVMW-GRNVYDSISKFLQF 846
Cdd:cd07541  647 SHIGRLLLWhGRNSYKRSAKLAQF 670
P-type_ATPase_FixI-like cd02092
Rhizobium meliloti FixI and related proteins; belongs to P-type heavy metal-transporting ...
195-872 1.56e-16

Rhizobium meliloti FixI and related proteins; belongs to P-type heavy metal-transporting ATPase subfamily; FixI may be a pump of a specific cation involved in symbiotic nitrogen fixation. The Rhizobium fixI gene is part of an operon conserved among rhizobia, fixGHIS. FixG, FixH, FixI, and FixS may participate in a membrane-bound complex coupling the FixI cation pump with a redox process catalyzed by FixG, an iron-sulfur protein. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319782 [Multi-domain]  Cd Length: 605  Bit Score: 84.72  E-value: 1.56e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  195 NGQLIQLPVAEIVVGDIAQVKYGDLLPADGILIQGNDLkIDESSLTGESDHVkkTLDKDPMLLSGTHVMEGSGRMVVTAV 274
Cdd:cd02092  134 DGSREYVPVAEIRPGDRVLVAAGERIPVDGTVVSGTSE-LDRSLLTGESAPV--TVAPGDLVQAGAMNLSGPLRLRATAA 210
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  275 GINSQTGIIFTLLganeeeddekkkkgkkqgvsENRNKAKTqdgvaleiqplnsqegldseekekkaskgpkkeksvlqg 354
Cdd:cd02092  211 GDDTLLAEIARLM--------------------EAAEQGRS--------------------------------------- 231
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  355 KLTRLAvqiGKAGLIMSILTVLILILYFVvdnfviqrrAWlpectpVYIQYFVKF-FIIGVTVLVVAVPEGLPLAVTISL 433
Cdd:cd02092  232 RYVRLA---DRAARLYAPVVHLLALLTFV---------GW------VAAGGDWRHaLLIAVAVLIITCPCALGLAVPAVQ 293
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  434 AYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTMNRMTVVQAyiggthyrqipkpDDLPPNVLDLIvnsicinsa 513
Cdd:cd02092  294 VVASGRLFRRGVLVKDGTALERLAEVDTVVFDKTGTLTLGSPRLVGA-------------HAISADLLALA--------- 351
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  514 ytskilppekeGGLprqvgnktecgllgfvtdlkqdyqAVRSEMPeeklfkvytfnsvrksMSTVIRKPEGGFRVFSKGA 593
Cdd:cd02092  352 -----------AAL------------------------AQASRHP----------------LSRALAAAAGARPVELDDA 380
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  594 SEImlrkcdrilnkeggivpfktkdrdnmvrnviepmASEGL--RTIGIAYR----DFDG--EEPSWENENEIFTGLVCI 665
Cdd:cd02092  381 REV----------------------------------PGRGVegRIDGARVRlgrpAWLGasAGVSTASELALSKGGEEA 426
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  666 AVVGIEDPVRPEVPDAINKCKRAGITVRMVTGDNVNTARAIATKCGIltpgddflclegkefnrlirnekgeveqekldk 745
Cdd:cd02092  427 ARFPFEDRPRPDAREAISALRALGLSVEILSGDREPAVRALARALGI--------------------------------- 473
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  746 vwprLRVLARSSPTDKHTLVKGiidsnIGEQRQVVAVTGDGTNDGPALKKADVGFAMGIAgTDVAKEASDIILTDDNFTS 825
Cdd:cd02092  474 ----EDWRAGLTPAEKVARIEE-----LKAQGRRVLMVGDGLNDAPALAAAHVSMAPASA-VDASRSAADIVFLGDSLAP 543
                        650       660       670       680
                 ....*....|....*....|....*....|....*....|....*..
gi 54312088  826 IVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFSGacitQDSPLKA 872
Cdd:cd02092  544 VPEAIEIARRARRLIRQNFALAIGYNVIAVPLAIAG----YVTPLIA 586
zntA PRK11033
zinc/cadmium/mercury/lead-transporting ATPase; Provisional
665-819 4.83e-16

zinc/cadmium/mercury/lead-transporting ATPase; Provisional


Pssm-ID: 236827 [Multi-domain]  Cd Length: 741  Bit Score: 83.50  E-value: 4.83e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088   665 IAVVGIEDPVRPEVPDAINKCKRAGITVRMVTGDNVNTARAIATKCGIltpgdDFlclegkefnrlirnekgeveqekld 744
Cdd:PRK11033  560 LGLIALQDTLRADARQAISELKALGIKGVMLTGDNPRAAAAIAGELGI-----DF------------------------- 609
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 54312088   745 kvwprlrvlaRSS--PTDKhtlVKGIIDSNigeQRQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILT 819
Cdd:PRK11033  610 ----------RAGllPEDK---VKAVTELN---QHAPLAMVGDGINDAPAMKAASIGIAMG-SGTDVALETADAALT 669
P-type_ATPase-Cd_Zn_Co_like cd07548
P-type heavy metal-transporting ATPase, similar to Bacillus subtilis CadA which appears to ...
670-834 5.49e-16

P-type heavy metal-transporting ATPase, similar to Bacillus subtilis CadA which appears to transport cadmium, zinc and cobalt but not copper out of the cell; Bacillus subtilis CadA/YvgW appears to transport cadmium, zinc and cobalt but not copper, out of the cell. Functions in metal ion resistance and cellular metal ion homeostasis. CadA/YvgW is also important for sporulation in B. subtilis, the significant specific expression of the cadA/yvgW gene during the late stage of sporulation, is controlled by forespore-specific sigma factor, sigma G, and mother cell-specific sigma factor, sigma E. This subfamily also includes Helicobacter pylori CadA an essential resistance pump with ion specificity towards Cd(2+), Zn(2+) and Co(2+), and Zn-transporting ATPase, ZiaA(N) in Synechocystis PCC 6803. Transcription of ziaA is induced by Zn under the control of the Zn responsive repressor ZiaR. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319847 [Multi-domain]  Cd Length: 604  Bit Score: 82.67  E-value: 5.49e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  670 IEDPVRPEVPDAINKCKRAGIT-VRMVTGDNVNTARAIATKCGIltpgddflclegkefnrlirnekgeveqeklDKVWP 748
Cdd:cd07548  426 ISDEIKEDAKEAIKGLKELGIKnLVMLTGDRKSVAEKVAKKLGI-------------------------------DEVYA 474
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  749 RLrvlarsSPTDKHTLVKGIIDSNIGEqrqvVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVK 828
Cdd:cd07548  475 EL------LPEDKVEKVEELKAESKGK----VAFVGDGINDAPVLARADVGIAMGGLGSDAAIEAADVVLMNDEPSKVAE 544

                 ....*.
gi 54312088  829 AVMWGR 834
Cdd:cd07548  545 AIKIAR 550
kdpB TIGR01497
K+-transporting ATPase, B subunit; This model describes the P-type ATPase subunit of the ...
195-834 1.20e-15

K+-transporting ATPase, B subunit; This model describes the P-type ATPase subunit of the complex responsible for translocating potassium ions across biological membranes in microbes. In E. coli and other species, this complex consists of the proteins KdpA, KdpB, KdpC and KdpF. KdpB is the ATPase subunit, while KdpA is the potassium-ion translocating subunit. The function of KdpC is unclear, although cit has been suggested to couple the ATPase subunit to the ion-translocating subunit, while KdpF serves to stabilize the complex. The potassium P-type ATPases have been characterized as Type IA based on a phylogenetic analysis which places this clade closest to the heavy-metal translocating ATPases (Type IB). Others place this clade closer to the Na+/K+ antiporter type (Type IIC) based on physical characteristics. This model is very clear-cut, with a strong break between trusted hits and noise. All members of the seed alignment, from Clostridium, Anabaena and E. coli are in the characterized table. One sequence above trusted, OMNI|NTL01TA01282, is apparently mis-annotated in the primary literature, but properly annotated by TIGR. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 130561 [Multi-domain]  Cd Length: 675  Bit Score: 81.85  E-value: 1.20e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    195 NGQLIQLPVAEIVVGDIAQVKYGDLLPADGILIQGNdLKIDESSLTGESDHVKKTLDKD-PMLLSGTHVMEGSGRMVVTA 273
Cdd:TIGR01497  113 DGAIDKVPADQLKKGDIVLVEAGDVIPCDGEVIEGV-ASVDESAITGESAPVIKESGGDfASVTGGTRILSDWLVVECTA 191
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    274 vgiNSQTGIIFTLLGaneeeddekkkkgkkqgVSENRNKAKTQDGVALEIqplnsqegldseekekkaskgpkkeksvlq 353
Cdd:TIGR01497  192 ---NPGETFLDRMIA-----------------LVEGAQRRKTPNEIALTI------------------------------ 221
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    354 gkltrlavqigkaglimsILTVLILILYFVVDNFVIQRrAWLPECTPVYIQyfvkffiigVTVLVVAVPE---GLPLAVT 430
Cdd:TIGR01497  222 ------------------LLIALTLVFLLVTATLWPFA-AYGGNAISVTVL---------VALLVCLIPTtigGLLSAIG 273
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    431 ISlaySVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTM-NRMTVVQAYIGGTHYRQIpkpddlppnvldlivnsic 509
Cdd:TIGR01497  274 IA---GMDRVLGFNVIATSGRAVEACGDVDTLLLDKTGTITLgNRLASEFIPAQGVDEKTL------------------- 331
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    510 INSAYTSKILPPEKEGGLPRQVGNKtecglLGFVTDLKQDYQAVRSEMpeeklfkvytfnSVRKSMSTVirKPEGGfRVF 589
Cdd:TIGR01497  332 ADAAQLASLADDTPEGKSIVILAKQ-----LGIREDDVQSLHATFVEF------------TAQTRMSGI--NLDNG-RMI 391
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    590 SKGASEIMLRKcdriLNKEGGIVPfktKDRDNMVRNViepmASEGLRTIGIAYrdfdgeepswenENEIFtglvciAVVG 669
Cdd:TIGR01497  392 RKGAVDAIKRH----VEANGGHIP---TDLDQAVDQV----ARQGGTPLVVCE------------DNRIY------GVIY 442
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    670 IEDPVRPEVPDAINKCKRAGITVRMVTGDNVNTARAIATKCGIltpgDDFLclegkefnrlirnekgeveqekldkvwpr 749
Cdd:TIGR01497  443 LKDIVKGGIKERFAQLRKMGIKTIMITGDNRLTAAAIAAEAGV----DDFI----------------------------- 489
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    750 lrvlARSSPTDKHTLVKGIIDsnigeQRQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDDNFTSIVKA 829
Cdd:TIGR01497  490 ----AEATPEDKIALIRQEQA-----EGKLVAMTGDGTNDAPALAQADVGVAMN-SGTQAAKEAANMVDLDSDPTKLIEV 559

                   ....*
gi 54312088    830 VMWGR 834
Cdd:TIGR01497  560 VHIGK 564
P-type_ATPase_HM cd07553
P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily ...
158-872 5.15e-15

P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily of the heavy metal-transporting ATPases (Type IB ATPases) which transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319851 [Multi-domain]  Cd Length: 610  Bit Score: 79.87  E-value: 5.15e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  158 SVIIVVFVTAFNDWSKEKQ-----FRGLQSRIELEQKFSIIRNGQLIQLPVAEIVVGDIAQVKYGDLLPADGILIQGNdL 232
Cdd:cd07553   93 SLSVLVFLMLVGRWLQVVTqernrNRLADSRLEAPITEIETGSGSRIKTRADQIKSGDVYLVASGQRVPVDGKLLSEQ-A 171
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  233 KIDESSLTGESdhVKKTLDKDPMLLSGTHVMEGSGRMVVTAVGINSQTGIIFtllganeeeddekkkkgkkQGVSEnrnk 312
Cdd:cd07553  172 SIDMSWLTGES--LPRIVERGDKVPAGTSLENQAFEIRVEHSLAESWSGSIL-------------------QKVEA---- 226
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  313 aktqdgvaleiqplnsqegldseekeKKASKGPkkeksvlqgkLTRLAVQIGKAGLIMSILTVLILILYFVVDNFVIQrr 392
Cdd:cd07553  227 --------------------------QEARKTP----------RDLLADKIIHYFTVIALLIAVAGFGVWLAIDLSIA-- 268
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  393 awlpectpvyiqyfVKFFIigvTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTM 472
Cdd:cd07553  269 --------------LKVFT---SVLIVACPCALALATPFTDEIALARLKKKGVLIKNASSLERLSRVRTIVFDKTGTLTR 331
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  473 NRMTVVQAyiggthyrqipKPDDLPPNVLDLIVNsICINSaytskilppekegglPRQVGNktecgllgfvtdlkqdyqA 552
Cdd:cd07553  332 GKSSFVMV-----------NPEGIDRLALRAISA-IEAHS---------------RHPISR------------------A 366
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  553 VRSEMPEEKLFKVytfnsvrkSMSTVIRKPEGGFRVFSKGASEIMLRKCDRILNKEGGIvpfktkdrdnmvrnviepmas 632
Cdd:cd07553  367 IREHLMAKGLIKA--------GASELVEIVGKGVSGNSSGSLWKLGSAPDACGIQESGV--------------------- 417
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  633 eglrtigIAYRDfdgeepswenenEIFTGLVCIavvgiEDPVRPEVPDAINKCKRAGITVRMVTGDNVNTARAIATKCGI 712
Cdd:cd07553  418 -------VIARD------------GRQLLDLSF-----NDLLRPDSNREIEELKKGGLSIAILSGDNEEKVRLVGDSLGL 473
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  713 ltpGDDflclegkefnrlirnekgeveqekldkvwprlRVLARSSPTDKHTLVKGIIDSNigeqrqvVAVTGDGTNDGPA 792
Cdd:cd07553  474 ---DPR--------------------------------QLFGNLSPEEKLAWIESHSPEN-------TLMVGDGANDALA 511
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  793 LKKADVGFAMGiAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFSGACitqdSPLKA 872
Cdd:cd07553  512 LASAFVGIAVA-GEVGVSLEAADIYYAGNGIGGIRDLLTLSKQTIKAIKGLFAFSLLYNLVAIGLALSGWI----SPLVA 586
copA PRK10671
copper-exporting P-type ATPase CopA;
665-830 6.02e-14

copper-exporting P-type ATPase CopA;


Pssm-ID: 182635 [Multi-domain]  Cd Length: 834  Bit Score: 76.70  E-value: 6.02e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088   665 IAVVGIEDPVRPEVPDAINKCKRAGITVRMVTGDNVNTARAIATKCGIltpgddflclegkefnrlirnekgeveqeklD 744
Cdd:PRK10671  642 AALLAIRDPLRSDSVAALQRLHKAGYRLVMLTGDNPTTANAIAKEAGI-------------------------------D 690
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088   745 kvwprlRVLARSSPTDKHTLVKgiidsNIGEQRQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDDNFT 824
Cdd:PRK10671  691 ------EVIAGVLPDGKAEAIK-----RLQSQGRQVAMVGDGINDAPALAQADVGIAMG-GGSDVAIETAAITLMRHSLM 758

                  ....*.
gi 54312088   825 SIVKAV 830
Cdd:PRK10671  759 GVADAL 764
PLN03190 PLN03190
aminophospholipid translocase; Provisional
410-714 1.02e-13

aminophospholipid translocase; Provisional


Pssm-ID: 215623 [Multi-domain]  Cd Length: 1178  Bit Score: 76.09  E-value: 1.02e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088   410 FIIGVTVLVVAVPEGLPLA---VTISLAYSvkkMMKDNNL----------VRHLDACETMGNATAICSDKTGTLTMNRMT 476
Cdd:PLN03190  394 FLMSVIVFQIMIPISLYISmelVRVGQAYF---MIRDDQMydeasnsrfqCRALNINEDLGQIKYVFSDKTGTLTENKME 470
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088   477 VVQAYIGGTHYRQIPKPDDLPPNVLDLIVNSICINSAYTSKILPPEKEggLPRQvGNKTE--------------CG-LLG 541
Cdd:PLN03190  471 FQCASIWGVDYSDGRTPTQNDHAGYSVEVDGKILRPKMKVKVDPQLLE--LSKS-GKDTEeakhvhdfflalaaCNtIVP 547
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088   542 FVTDLKQD-------YQAvrsEMPEEK---------------------------------LFKVYTFNSVRKSMSTVIRK 581
Cdd:PLN03190  548 IVVDDTSDptvklmdYQG---ESPDEQalvyaaaaygfmliertsghividihgerqrfnVLGLHEFDSDRKRMSVILGC 624
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088   582 PEGGFRVFSKGASEIMLRKCDRILNKeggivpfktkdrdNMVRNV---IEPMASEGLRTIGIAYRDFDGEE-PSWENENE 657
Cdd:PLN03190  625 PDKTVKVFVKGADTSMFSVIDRSLNM-------------NVIRATeahLHTYSSLGLRTLVVGMRELNDSEfEQWHFSFE 691
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 54312088   658 -------------------IFTGLVCIAVVGIEDPVRPEVPDAINKCKRAGITVRMVTGDNVNTARAIATKCGILT 714
Cdd:PLN03190  692 aastaligraallrkvasnVENNLTILGASAIEDKLQQGVPEAIESLRTAGIKVWVLTGDKQETAISIGYSSKLLT 767
Cation_ATPase_N pfam00690
Cation transporter/ATPase, N-terminus; Members of this families are involved in Na+/K+, H+/K+, ...
46-110 6.81e-11

Cation transporter/ATPase, N-terminus; Members of this families are involved in Na+/K+, H+/K+, Ca++ and Mg++ transport.


Pssm-ID: 459907 [Multi-domain]  Cd Length: 68  Bit Score: 59.11  E-value: 6.81e-11
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 54312088     46 AHYGSVQEICARLKTSPVEGLSgnPADLEKRRLVFGKNMIPPKKPKTFLELVWEALQDVTLIILE 110
Cdd:pfam00690    1 WHALSVEEVLKKLGTDLEKGLT--EAEAEKRLKKYGPNELPEKKPKSLWKLFLRQFKDPLIIILL 63
ATP_Ca_trans_C pfam12424
Plasma membrane calcium transporter ATPase C terminal; This domain family is found in ...
1089-1126 8.13e-11

Plasma membrane calcium transporter ATPase C terminal; This domain family is found in eukaryotes, and is approximately 60 amino acids in length. The family is found in association with pfam00689, pfam00122, pfam00702, pfam00690. There is a conserved QTQ sequence motif. This family is the C terminal of a calcium transporting ATPase located in the plasma membrane.


Pssm-ID: 463575  Cd Length: 47  Bit Score: 58.19  E-value: 8.13e-11
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 54312088   1089 GQILWVRGLNRIQTQIEVINKFQTGAsFKGVLRRQNLS 1126
Cdd:pfam12424    1 GQILWFRGLNRIQTQIRVVKAFQSSL-REGIQKPYLRN 37
PRK14010 PRK14010
K(+)-transporting ATPase subunit B;
155-852 8.37e-11

K(+)-transporting ATPase subunit B;


Pssm-ID: 184448 [Multi-domain]  Cd Length: 673  Bit Score: 66.26  E-value: 8.37e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088   155 ILASVIIVVFVTAFNDWSKEKQFRGL-QSRIELEQKfSIIRNGQLIQLPVAEIVVGDIAQVKYGDLLPADGILIQGNdLK 233
Cdd:PRK14010   72 LLLTLVFANFSEALAEGRGKAQANALrQTQTEMKAR-RIKQDGSYEMIDASDLKKGHIVRVATGEQIPNDGKVIKGL-AT 149
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088   234 IDESSLTGESDHVKKTLDKD-PMLLSGTHVMEGSGRMVVTAVGINSQTGIIFTLLganeeeddekkkkgkkqgvsENRNK 312
Cdd:PRK14010  150 VDESAITGESAPVIKESGGDfDNVIGGTSVASDWLEVEITSEPGHSFLDKMIGLV--------------------EGATR 209
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088   313 AKTQDGVALeiqplnsqegldseekekkaskgpkkeksvlqgkltrlavqigkaglIMSILTVLILILYFVVDNFviqrr 392
Cdd:PRK14010  210 KKTPNEIAL-----------------------------------------------FTLLMTLTIIFLVVILTMY----- 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088   393 awlPECTPVYIQYFVKFFIIGVTVLVVAVPEGLPLAVTISlaySVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTM 472
Cdd:PRK14010  238 ---PLAKFLNFNLSIAMLIALAVCLIPTTIGGLLSAIGIA---GMDRVTQFNILAKSGRSVETCGDVNVLILDKTGTITY 311
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088   473 -NRMTVVQAYIGGTHYRQIpkpddlppnvldlivnsicINSAYTSKILPPEKEGGLPRQVGNKTEcgllgfvTDLKQDYQ 551
Cdd:PRK14010  312 gNRMADAFIPVKSSSFERL-------------------VKAAYESSIADDTPEGRSIVKLAYKQH-------IDLPQEVG 365
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088   552 AVRSEMPEEKLFKVYTFNsvrksmstvirkpeggfRVFSKGASEIMLRKcdriLNKEGGIVPfktKDRDNMVRNVIEpma 631
Cdd:PRK14010  366 EYIPFTAETRMSGVKFTT-----------------REVYKGAPNSMVKR----VKEAGGHIP---VDLDALVKGVSK--- 418
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088   632 seglrtigiayrdfDGEEPSWENENEIFTGlvciaVVGIEDPVRPEVPDAINKCKRAGITVRMVTGDNVNTARAIATKCG 711
Cdd:PRK14010  419 --------------KGGTPLVVLEDNEILG-----VIYLKDVIKDGLVERFRELREMGIETVMCTGDNELTAATIAKEAG 479
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088   712 ILtpgddflclegkefnrlirnekgeveqekldkvwprlRVLARSSPTDKHTLVKGiidsnigEQRQ--VVAVTGDGTND 789
Cdd:PRK14010  480 VD-------------------------------------RFVAECKPEDKINVIRE-------EQAKghIVAMTGDGTND 515
                         650       660       670       680       690       700
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 54312088   790 GPALKKADVGFAMGiAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNV 852
Cdd:PRK14010  516 APALAEANVGLAMN-SGTMSAKEAANLIDLDSNPTKLMEVVLIGKQLLMTRGSLTTFSIANDI 577
Hydrolase pfam00702
haloacid dehalogenase-like hydrolase; This family is structurally different from the alpha ...
636-797 1.00e-08

haloacid dehalogenase-like hydrolase; This family is structurally different from the alpha/beta hydrolase family (pfam00561). This family includes L-2-haloacid dehalogenase, epoxide hydrolases and phosphatases. The structure of the family consists of two domains. One is an inserted four helix bundle, which is the least well conserved region of the alignment, between residues 16 and 96 of Swiss:P24069. The rest of the fold is composed of the core alpha/beta domain. Those members with the characteriztic DxD triad at the N-terminus are probably phosphatidylglycerolphosphate (PGP) phosphatases involved in cardiolipin biosynthesis in the mitochondria.


Pssm-ID: 459910 [Multi-domain]  Cd Length: 191  Bit Score: 56.44  E-value: 1.00e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    636 RTIGIAYRDFDGEEPSWENENEIFTG---------LVCIAVVGIEDPVRPEVPDAINKCKRAGITVRMVTGDNVNTARAI 706
Cdd:pfam00702   52 ARLLLGKRDWLEELDILRGLVETLEAegltvvlveLLGVIALADELKLYPGAAEALKALKERGIKVAILTGDNPEAAEAL 131
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    707 ATKCGILTPGDDFLCLEGKEFnrlirnekgeveqekldkvwprlrvlARSSPTDKHTLVKgiidsNIGEQRQVVAVTGDG 786
Cdd:pfam00702  132 LRLLGLDDYFDVVISGDDVGV--------------------------GKPKPEIYLAALE-----RLGVKPEEVLMVGDG 180
                          170
                   ....*....|.
gi 54312088    787 TNDGPALKKAD 797
Cdd:pfam00702  181 VNDIPAAKAAG 191
SerB COG0560
Phosphoserine phosphatase [Amino acid transport and metabolism]; Phosphoserine phosphatase is ...
673-801 1.09e-05

Phosphoserine phosphatase [Amino acid transport and metabolism]; Phosphoserine phosphatase is part of the Pathway/BioSystem: Serine biosynthesis


Pssm-ID: 440326 [Multi-domain]  Cd Length: 221  Bit Score: 47.91  E-value: 1.09e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  673 PVRPEVPDAINKCKRAGITVRMVTGDNVNTARAIATKCGIltpgDDFLClegkefNRL-IRNEK--GEVEQEKLD---KV 746
Cdd:COG0560   88 RLYPGARELIAEHRAAGHKVAIVSGGFTFFVEPIAERLGI----DHVIA------NELeVEDGRltGEVVGPIVDgegKA 157
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 54312088  747 WpRLRVLARSsptdkhtlvKGIidsnigEQRQVVAVtGDGTNDGPALKKADVGFA 801
Cdd:COG0560  158 E-ALRELAAE---------LGI------DLEQSYAY-GDSANDLPMLEAAGLPVA 195
Cation_ATPase_N smart00831
Cation transporter/ATPase, N-terminus; This entry represents the conserved N-terminal region ...
47-119 4.25e-05

Cation transporter/ATPase, N-terminus; This entry represents the conserved N-terminal region found in several classes of cation-transporting P-type ATPases, including those that transport H+, Na+, Ca2+, Na+/K+, and H+/K+. In the H+/K+- and Na+/K+-exchange P-ATPases, this domain is found in the catalytic alpha chain. In gastric H+/K+-ATPases, this domain undergoes reversible sequential phosphorylation inducing conformational changes that may be important for regulating the function of these ATPases.


Pssm-ID: 214842 [Multi-domain]  Cd Length: 75  Bit Score: 42.96  E-value: 4.25e-05
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 54312088      47 HYGSVQEICARLKTSPVEGLSgnPADLEKRRLVFGKNMIPPKKPKTFLELVWEALQDVTLIILEIAAIISLVL 119
Cdd:smart00831    5 HALSLEEVLERLQTDLEKGLS--SEEAARRLERYGPNELPPPKKTSPLLRFLRQFHNPLIYILLAAAVLSALL 75
Cof COG0561
Hydroxymethylpyrimidine pyrophosphatase and other HAD family phosphatases [Coenzyme transport ...
676-822 2.05e-04

Hydroxymethylpyrimidine pyrophosphatase and other HAD family phosphatases [Coenzyme transport and metabolism, General function prediction only];


Pssm-ID: 440327 [Multi-domain]  Cd Length: 192  Bit Score: 43.59  E-value: 2.05e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  676 PEVPDAINKCKRAGITVRMVTGDNVNTARAIATKCGILTPgddFLCLEGKefnrLIRNEKGEV------EQEKLDKVWPR 749
Cdd:COG0561   22 PRTKEALRRLREKGIKVVIATGRPLRSALPLLEELGLDDP---LITSNGA----LIYDPDGEVlyerplDPEDVREILEL 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088  750 LR-------VLARSSPT---------DKHTLVKGIIDS-NIgEQRQVVAVtGDGTNDGPALKKADVGFAMGIAgTDVAKE 812
Cdd:COG0561   95 LRehglhlqVVVRSGPGfleilpkgvSKGSALKKLAERlGI-PPEEVIAF-GDSGNDLEMLEAAGLGVAMGNA-PPEVKA 171
                        170
                 ....*....|
gi 54312088  813 ASDIIlTDDN 822
Cdd:COG0561  172 AADYV-TGSN 180
Cof-subfamily TIGR00099
Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; This subfamily of ...
713-822 5.99e-04

Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; This subfamily of sequences falls within the Class-IIB subfamily (TIGR01484) of the Haloacid Dehalogenase superfamily of aspartate-nucleophile hydrolases. The use of the name "Cof" as an identifier here is arbitrary and refers to the E. coli Cof protein. This subfamily is notable for the large number of recent paralogs in many species. Listeria, for instance, has 12, Clostridium, Lactococcus and Streptococcus pneumoniae have 8 each, Enterococcus and Salmonella have 7 each, and Bacillus subtilus, Mycoplasma, Staphylococcus and E. coli have 6 each. This high degree of gene duplication is limited to the gamma proteobacteria and low-GC gram positive lineages. The profusion of genes in this subfamily is not coupled with a high degree of divergence, so it is impossible to determine an accurate phylogeny at the equivalog level. Considering the relationship of this subfamily to the other known members of the HAD-IIB subfamily (TIGR01484), sucrose and trehalose phosphatases and phosphomannomutase, it seems a reasonable hypothesis that these enzymes act on phosphorylated sugars. Possibly the diversification of genes in this subfamily represents the diverse sugars and polysaccharides that various bacteria find in their biological niches. The members of this subfamily are restricted almost exclusively to bacteria (one sequences from S. pombe scores above trusted, while another is between trusted and noise). It is notable that no archaea are found in this group, the closest relations to the archaea found here being two Deinococcus sequences. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 272905 [Multi-domain]  Cd Length: 256  Bit Score: 43.03  E-value: 5.99e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    713 LTPGDDF----LCLEGKEFNRLIRNEKGEVEQEKLDKVWPR---LRVLARSspTDKHTLVKGIIDsNIGEQRQVVAVTGD 785
Cdd:TIGR00099  136 YLPDDILkillLFLDPEDLDLLIEALNKLELEENVSVVSSGpysIEITAKG--VSKGSALQSLAE-ALGISLEDVIAFGD 212
                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 54312088    786 GTNDGPALKKADVGFAMGIAgTDVAKEASDIIlTDDN 822
Cdd:TIGR00099  213 GMNDIEMLEAAGYGVAMGNA-DEELKALADYV-TDSN 247
HAD-SF-IB TIGR01488
Haloacid Dehalogenase superfamily, subfamily IB, phosphoserine phosphatase-like; This model ...
673-796 4.28e-03

Haloacid Dehalogenase superfamily, subfamily IB, phosphoserine phosphatase-like; This model represents a subfamily of the Haloacid Dehalogenase superfamily of aspartate-nucleophile hydrolases. Subfamily IA, B, C and D are distinguished from the rest of the superfamily by the presence of a variable domain between the first and second conserved catalytic motifs. In subfamilies IA and IB, this domain consists of an alpha-helical bundle. It was necessary to model these two subfamilies separately, breaking them at a an apparent phylogenetic bifurcation, so that the resulting model(s) are not so broadly defined that members of subfamily III (which lack the variable domain) are included. Subfamily IA includes the enzyme phosphoserine phosphatase (TIGR00338) as well as three hypothetical equivalogs. Many members of these hypothetical equivalogs have been annotated as PSPase-like or PSPase-family proteins. In particular, the hypothetical equivalog which appears to be most closely related to PSPase contains only Archaea (while TIGR00338 contains only eukaryotes and bacteria) of which some are annotated as PSPases. Although this is a reasonable conjecture, none of these sequences has sufficient evidence for this assignment. If such should be found, this model should be retired while the PSPase model should be broadened to include these sequences. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 273653 [Multi-domain]  Cd Length: 177  Bit Score: 39.64  E-value: 4.28e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54312088    673 PVRPEVPDAINKCKRAGITVRMVTGDNVNTARAIATKCGIltpgDDFLC--LEGKEFNRLIRNEKGEVEQEKLDKVwPRL 750
Cdd:TIGR01488   73 ALRPGARELISWLKERGIDTVIVSGGFDFFVEPVAEKLGI----DDVFAnrLEFDDNGLLTGPIEGQVNPEGECKG-KVL 147
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 54312088    751 RVLARSSPTDKhtlvkgiidsnigeqRQVVAVtGDGTNDGPALKKA 796
Cdd:TIGR01488  148 KELLEESKITL---------------KKIIAV-GDSVNDLPMLKLA 177
Hydrolase_3 pfam08282
haloacid dehalogenase-like hydrolase; This family contains haloacid dehalogenase-like ...
778-829 7.18e-03

haloacid dehalogenase-like hydrolase; This family contains haloacid dehalogenase-like hydrolase enzymes.


Pssm-ID: 429897 [Multi-domain]  Cd Length: 255  Bit Score: 39.53  E-value: 7.18e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 54312088    778 QVVAVtGDGTNDGPALKKADVGFAMGIAgTDVAKEASDIILTDDNFTSIVKA 829
Cdd:pfam08282  205 EVIAF-GDGENDIEMLEAAGLGVAMGNA-SPEVKAAADYVTDSNNEDGVAKA 254
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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