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    L4 capsid protein precursor pVIII;encapsidation protein 22K;hexon assembly protein 100K;protein 33K [ Human mastadenovirus C ]

    Gene ID: 2653005, updated on 6-Jun-2024

    Summary

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    Gene symbol
    L4
    Gene description
    capsid protein precursor pVIII;encapsidation protein 22K;hexon assembly protein 100K;protein 33K
    Locus tag
    HAdVC_gp07
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Human mastadenovirus C (serotype: Human adenovirus 2, acronym: HAdV-2, acronym: HAdV-C, nat-host: Homo sapiens)
    Lineage
    Viruses; Varidnaviria; Bamfordvirae; Preplasmiviricota; Tectiliviricetes; Rowavirales; Adenoviridae; Mastadenovirus
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    Genomic context

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    Sequence:
    NC_001405.1 (6008..28223)

    NC_001405.1Genomic Context describing neighboring genes Neighboring gene control protein E1A;control protein E1A 243R Neighboring gene control protein E1B 19K;control protein E1B 55K Neighboring gene encapsidation protein IVa2 Neighboring gene capsid protein IX Neighboring gene DNA polymerase;terminal protein precursor pTP Neighboring gene fiber Neighboring gene capsid protein precursor pVI;hexon;protease Neighboring gene core protein V;core protein precursor pVII;core protein precursor pX;penton base Neighboring gene capsid protein precursor pIIIa;encapsidation protein 52K;protein 13.6K Neighboring gene miscRNA Neighboring gene miscRNA Neighboring gene single-stranded DNA-binding protein Neighboring gene Neighboring gene control protein E3 12.5K;membrane glycoprotein E3 CR1-alpha;membrane glycoprotein E3 CR1-beta;membrane glycoprotein E3 gp19K Neighboring gene control protein E3 14.7K;membrane protein E3 RID-alpha;membrane protein E3 RID-beta Neighboring gene protein U Neighboring gene control protein E4 34K;control protein E4orf1;control protein E4orf2;control protein E4orf3;control protein E4orf4;control protein E4orf6/7

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001405.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The adenovirus L4-22K protein has distinct functions in the posttranscriptional regulation of gene expression and encapsidation of the viral genome. Guimet D, et al. J Virol, 2013 Jul. PMID 23637408, Free PMC Article
    2. The adenovirus L4-22K protein is multifunctional and is an integral component of crucial aspects of infection. Wu K, et al. J Virol, 2012 Oct. PMID 22811519, Free PMC Article
    3. Adenovirus serotype 5-specific neutralizing antibodies target multiple hexon hypervariable regions. Bradley RR, et al. J Virol, 2012 Jan. PMID 22072746, Free PMC Article
    4. Adenovirus late-phase infection is controlled by a novel L4 promoter. Morris SJ, et al. J Virol, 2010 Jul. PMID 20444889, Free PMC Article
    5. Arginine methylation of human adenovirus type 5 L4 100-kilodalton protein is required for efficient virus production. Koyuncu OO, et al. J Virol, 2009 May. PMID 19264777, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The adenovirus L4-22K protein has distinct functions in the posttranscriptional regulation of gene expression and encapsidation of the viral genome.
      Title: The adenovirus L4-22K protein has distinct functions in the posttranscriptional regulation of gene expression and encapsidation of the viral genome.
    2. Amino acid substitutions in the potential nuclear export signal in L4-100K resulted in severely diminished progeny virus production, seemingly by precluding proper hexon biogenesis.
      Title: Amino acid exchanges in the putative nuclear export signal of adenovirus type 5 L4-100K severely reduce viral progeny due to effects on hexon biogenesis.
    3. the adenovirus L4-22K protein is multifunctional and an integral component of crucial aspects of infect
      Title: The adenovirus L4-22K protein is multifunctional and is an integral component of crucial aspects of infection.
    4. Neutralizing antibodies target multiple hexon hypervariable regions.
      Title: Adenovirus serotype 5-specific neutralizing antibodies target multiple hexon hypervariable regions.
    5. findings show that 2 key positive regulators of the major late gene, L4-22K and L4-33K initially are expressed from a novel promoter embedded within the major late gene and dedicated to their expression; this promoter is required for late gene expression
      Title: Adenovirus late-phase infection is controlled by a novel L4 promoter.
    6. Arginine-to-glycine exchanges in the RGG boxes significantly diminished L4-100K methylation and substantially reduced virus growth.
      Title: Arginine methylation of human adenovirus type 5 L4 100-kilodalton protein is required for efficient virus production.
    7. These results indicate that L4-22K plays a key role in the early-late switch in MLTU expression, additional to and distinct from the role of L4-33K.
      Title: Adenovirus serotype 5 L4-22K and L4-33K proteins have distinct functions in regulating late gene expression.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    prim_transcript

    • Loc: 6039-14113 experiment = transcript mapping
    • Loc: 6039-17969 experiment = transcript mapping
    • Loc: 6039-22443 experiment = transcript mapping
    • Loc: 6039-28223 experiment = transcript mapping

    regulatory

    • Loc: 14092-14097 regulatory_class = polyA_signal_sequence
    • Loc: 17949-17954 regulatory_class = polyA_signal_sequence
    • Loc: 22418-22423 regulatory_class = polyA_signal_sequence
    • Loc: 27580-27585 regulatory_class = TATA_box
    • Loc: 28205-28210 regulatory_class = polyA_signal_sequence
    • Loc: 6008-6013 regulatory_class = TATA_box

    General protein information

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    Preferred Names
    capsid protein precursor pVIII;encapsidation protein 22K;hexon assembly protein 100K;protein 33K
    NP_040528.1
    • genus-common

    VOG classification

    Description:

    • VOGd0018 [A] 100 kd late nonstructural protein, cytoplasm_to_nucleus hexon transport protein
    • Auxilary Proteins
    NP_040529.1
    • genus-common

    VOG classification

    Description:

    • VOGd0166 [A] Virion morphogenesis-associated protein
    • Auxilary Proteins
    NP_040530.1
    • genus-common

    VOG classification

    Description:

    • VOGd0020 [S] Hexon associated protein VIII
    • Structural Proteins
    YP_001551767.1
    • genus-common

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001405.1 Reference assembly

      Range
      6008..28223
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_040528.1 hexon assembly protein 100K [Human mastadenovirus C]

      See identical proteins and their annotated locations for NP_040528.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P03268, P24932
      UniProtKB/TrEMBL
      A0A3Q9HKB6, A0A3Q9HKK0, A0A3Q9HLE9, A0A3S9SN30, A0A3S9SS18, A0A3S9SSQ5, A0A4V0NN52, A0A8F9RAI3, A0A8F9RBS7, A0AAF1BYC0, J9Z3W9, T1UEZ9
      Conserved Domains (1) summary
      pfam02438
      Location:98 → 691
      Adeno_100; Late 100kD protein

    2. NP_040529.1 protein 33K [Human mastadenovirus C]

      See identical proteins and their annotated locations for NP_040529.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P24939
      UniProtKB/TrEMBL
      A0A2H4PJ85, A0A3Q9HK88, A0A4P2SJE6, A0A6M5EBJ4, A0AAF0YYQ2, J9Z3F1, T1UHM3
      Conserved Domains (1) summary
      pfam11081
      Location:1 → 225
      DUF2890; Protein of unknown function (DUF2890)

    3. YP_001551767.1 encapsidation protein 22K [Human mastadenovirus C]

      See identical proteins and their annotated locations for YP_001551767.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P0DJX1
      UniProtKB/TrEMBL
      A0A2H4PJ81, A0A3Q9HJN2, A0A3Q9HK29, A0A3Q9HK85, A0A3Q9HL30, A0A3S9SNT7, A0A481ZK42, A0A4P2SH07, A0A8F9RB47, A0AAF0YXE6, A0AAF0YYU8, J9Z545, T1UF31
      Conserved Domains (1) summary
      pfam11081
      Location:15 → 176
      DUF2890; Protein of unknown function (DUF2890)

    4. NP_040530.1 capsid protein precursor pVIII [Human mastadenovirus C]

      See identical proteins and their annotated locations for NP_040530.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P03280
      UniProtKB/TrEMBL
      A0A0U5BNW0, A0A1U9ALM1, A0A3Q9HLK9, A0A3S9SS30, A0A5J6SGP3, A0A6M5E6N7, A0A6M6AAD0, A0A7D6XQT4, A0AA52I2C2, A0AAF0YUB7, A0AAF0Z333, E1ARR7, E1U5P6, J7IDL8, J9Z5R3, Q2KS02, Q6VGU2, Q71BW3, T1UM71
      Conserved Domains (1) summary
      pfam01310
      Location:3 → 223
      Adeno_PVIII; Adenovirus hexon associated protein, protein VIII
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    AAA92218.1
    AAA92219.1
    AAA92220.1

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