NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|9626181|ref|NP_040529|]
View 

protein 33K [Human mastadenovirus C]

Protein Classification

splicing factor family protein( domain architecture ID 10567434)

splicing factor family protein is a DUF2890 domain-containing protein; similar to Human adenovirus protein 33K and packaging protein 2

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
Adeno_L433K_22K pfam11081
Adenovirus L4-33K/L4-22K; Adenoviruses express up to 20 distinct mRNAs from five major late ...
1-225 1.03e-54

Adenovirus L4-33K/L4-22K; Adenoviruses express up to 20 distinct mRNAs from five major late transcription unit (MLTU) regions, L1 to L5. The L4 region expresses L4-33K and a related protein, L4-22K. L4-22K and L4-33K have complementary but not redundant functions that provide the normal pattern of mRNA production during the late phase of infection. L4-33K is an alternative RNA splicing factor that up-regulates several MLTU splice acceptor sites as the late phase progresses. L4-22K plays a role in genome packaging via its binding, in association with IVa2, to the A2 sequence within the packaging signal. Additionally, L4-22K plays an important role in the temporal switch from the early to late phase of infection by regulating both early and late gene expression.


:

Pssm-ID: 314108  Cd Length: 168  Bit Score: 172.88  E-value: 1.03e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9626181      1 MAPKKKLQLPPPPPTDEEEYWDSQAEEVLDEEEEMMEDWDSLDEASEAEEVSDETPSPSVAFPSPAPQKLATVPSIATTS 80
Cdd:pfam11081   1 MAPKKKLQLPPPPPTDEEEYWDSQAEEVLDEEEEMMEDWDSLDEASEAEEVSDETPSPSVAFPSPAPQKLATVPSIATTS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9626181     81 APQAPPALPVRRPNRRWDTTGTRAAptapaaaaaaataavtqKQRRPdsktltkpkkstaaaaagggalrlapnepvstr 160
Cdd:pfam11081  81 APQAPPALPVRRPNRRWDTTGTRAG-----------------KSKQP--------------------------------- 110
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 9626181    161 elrnrifPTLYAIFQQSRGQEQELKIKNRSLRSLTRSCLYHKSEDQLRRTLEDAEALFSKYCALT 225
Cdd:pfam11081 111 -------PPLAQEQQQRQGYRSWRGIKNRTPASLTRRYLYHRDLKKLRQYLEDAKKLYSKYCTQS 168
 
Name Accession Description Interval E-value
Adeno_L433K_22K pfam11081
Adenovirus L4-33K/L4-22K; Adenoviruses express up to 20 distinct mRNAs from five major late ...
1-225 1.03e-54

Adenovirus L4-33K/L4-22K; Adenoviruses express up to 20 distinct mRNAs from five major late transcription unit (MLTU) regions, L1 to L5. The L4 region expresses L4-33K and a related protein, L4-22K. L4-22K and L4-33K have complementary but not redundant functions that provide the normal pattern of mRNA production during the late phase of infection. L4-33K is an alternative RNA splicing factor that up-regulates several MLTU splice acceptor sites as the late phase progresses. L4-22K plays a role in genome packaging via its binding, in association with IVa2, to the A2 sequence within the packaging signal. Additionally, L4-22K plays an important role in the temporal switch from the early to late phase of infection by regulating both early and late gene expression.


Pssm-ID: 314108  Cd Length: 168  Bit Score: 172.88  E-value: 1.03e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9626181      1 MAPKKKLQLPPPPPTDEEEYWDSQAEEVLDEEEEMMEDWDSLDEASEAEEVSDETPSPSVAFPSPAPQKLATVPSIATTS 80
Cdd:pfam11081   1 MAPKKKLQLPPPPPTDEEEYWDSQAEEVLDEEEEMMEDWDSLDEASEAEEVSDETPSPSVAFPSPAPQKLATVPSIATTS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9626181     81 APQAPPALPVRRPNRRWDTTGTRAAptapaaaaaaataavtqKQRRPdsktltkpkkstaaaaagggalrlapnepvstr 160
Cdd:pfam11081  81 APQAPPALPVRRPNRRWDTTGTRAG-----------------KSKQP--------------------------------- 110
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 9626181    161 elrnrifPTLYAIFQQSRGQEQELKIKNRSLRSLTRSCLYHKSEDQLRRTLEDAEALFSKYCALT 225
Cdd:pfam11081 111 -------PPLAQEQQQRQGYRSWRGIKNRTPASLTRRYLYHRDLKKLRQYLEDAKKLYSKYCTQS 168
 
Name Accession Description Interval E-value
Adeno_L433K_22K pfam11081
Adenovirus L4-33K/L4-22K; Adenoviruses express up to 20 distinct mRNAs from five major late ...
1-225 1.03e-54

Adenovirus L4-33K/L4-22K; Adenoviruses express up to 20 distinct mRNAs from five major late transcription unit (MLTU) regions, L1 to L5. The L4 region expresses L4-33K and a related protein, L4-22K. L4-22K and L4-33K have complementary but not redundant functions that provide the normal pattern of mRNA production during the late phase of infection. L4-33K is an alternative RNA splicing factor that up-regulates several MLTU splice acceptor sites as the late phase progresses. L4-22K plays a role in genome packaging via its binding, in association with IVa2, to the A2 sequence within the packaging signal. Additionally, L4-22K plays an important role in the temporal switch from the early to late phase of infection by regulating both early and late gene expression.


Pssm-ID: 314108  Cd Length: 168  Bit Score: 172.88  E-value: 1.03e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9626181      1 MAPKKKLQLPPPPPTDEEEYWDSQAEEVLDEEEEMMEDWDSLDEASEAEEVSDETPSPSVAFPSPAPQKLATVPSIATTS 80
Cdd:pfam11081   1 MAPKKKLQLPPPPPTDEEEYWDSQAEEVLDEEEEMMEDWDSLDEASEAEEVSDETPSPSVAFPSPAPQKLATVPSIATTS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9626181     81 APQAPPALPVRRPNRRWDTTGTRAAptapaaaaaaataavtqKQRRPdsktltkpkkstaaaaagggalrlapnepvstr 160
Cdd:pfam11081  81 APQAPPALPVRRPNRRWDTTGTRAG-----------------KSKQP--------------------------------- 110
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 9626181    161 elrnrifPTLYAIFQQSRGQEQELKIKNRSLRSLTRSCLYHKSEDQLRRTLEDAEALFSKYCALT 225
Cdd:pfam11081 111 -------PPLAQEQQQRQGYRSWRGIKNRTPASLTRRYLYHRDLKKLRQYLEDAKKLYSKYCTQS 168
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH