PRMT4B protein arginine methyltransferase 4B [Arabidopsis thaliana (thale cress)] - Gene

Summary

Go to the top of the page Help

Official Symbol: PRMT4B
Official Full Name: protein arginine methyltransferase 4B
Primary source: TAIR:AT3G06930
Locus tag: AT3G06930
See related: Araport:AT3G06930
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ARABIDOPSIS THALIANA PROTEIN ARGININE METHYLTRANSFERASE 4B; ATPRMT4B; protein arginine methyltransferase 4B
Summary: Encodes an type I protein arginine methyltransferase. PRMT4b can catalyze the asymmetric dimethylation of arginines 2,17, and 26 on histone 3 and can also methylate myelin basic protein in vitro. Double mutants lacking PRMT4a and 4b have reduced levels of histone 3 methylated at R17. These double mutants flower late due to defects in the autonomous pathway and they have elevated levels of FLC transcripts.
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See PRMT4B in Genome Data Viewer

Location:: chromosome: 3

Exon count:: 15

Sequence:: Chromosome: 3; NC_003074.8 (2185129..2189434, complement)

Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

required for proper regulation of flowering time mainly through the FLOWERING LOCUS C-dependent pathway
Title: Redundant requirement for a pair of PROTEIN ARGININE METHYLTRANSFERASE4 homologs for the proper regulation of Arabidopsis flowering time.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

Orthologs from OrthoDB

NM_111573.5

Supported by ESTs:

NM_180197.2

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables histone H3R17 methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone H3R17 methyltransferase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables histone H3R2 methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone H3R26 methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables protein-arginine N-methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein-arginine omega-N asymmetric methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein-arginine omega-N monomethyltransferase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in epigenetic regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within peptidyl-arginine methylation, to asymmetrical-dimethyl arginine	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of flower development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to cadmium ion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to salt stress	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within vegetative to reproductive phase transition of meristem	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	HDA more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: protein arginine methyltransferase 4B

NP_187349.2

protein arginine methyltransferase 4B (PRMT4B); CONTAINS InterPro DOMAIN/s: Skb1 methyltransferase (InterPro:IPR007857); BEST Arabidopsis thaliana protein match is: protein arginine methyltransferase 4A (TAIR:AT5G49020.1); Has 2741 Blast hits to 2716 proteins in 617 species: Archae - 50; Bacteria - 577; Metazoa - 1205; Fungi - 251; Plants - 344; Viruses - 1; Other Eukaryotes - 313 (source: NCBI BLink).

NP_850528.1

protein arginine methyltransferase 4B (PRMT4B); CONTAINS InterPro DOMAIN/s: Skb1 methyltransferase (InterPro:IPR007857); BEST Arabidopsis thaliana protein match is: protein arginine methyltransferase 4A (TAIR:AT5G49020.1); Has 2741 Blast hits to 2716 proteins in 617 species: Archae - 50; Bacteria - 577; Metazoa - 1204; Fungi - 251; Plants - 344; Viruses - 1; Other Eukaryotes - 314 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003074.8 Reference assembly

Range

2185129..2189434 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_111573.5 → NP_187349.2 protein arginine methyltransferase 4B [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_187349.2

Status: REVIEWED

UniProtKB/TrEMBL

A0A178VEK8, A0A5S9XA67, A0A7G2EGI3

Conserved Domains (1) summary

cl17173
Location:157 → 297

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
NM_180197.2 → NP_850528.1 protein arginine methyltransferase 4B [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_850528.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q0WRU3, Q66GI8, Q84W92, Q9M906

UniProtKB/TrEMBL

A0A7G2EGI3

Conserved Domains (2) summary

pfam05185
Location:186 → 436

PRMT5; PRMT5 arginine-N-methyltransferase

cl17173
Location:157 → 297

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...