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Conserved domains on  [gi|30680066|ref|NP_187349|]
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protein arginine methyltransferase 4B [Arabidopsis thaliana]

Protein Classification

SAM-dependent methyltransferase( domain architecture ID 1905023)

SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

EC:  2.1.1.-
Gene Ontology:  GO:1904047|GO:0008168
PubMed:  12826405|12504684
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG4076 super family cl44002
Predicted RNA methylase [General function prediction only];
150-348 2.17e-45

Predicted RNA methylase [General function prediction only];


The actual alignment was detected with superfamily member COG4076:

Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 159.43  E-value: 2.17e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680066 150 HYYGQLLH---QQNMLQDYVRTGTYYAAVMenHSDFAGRVVVDVGAGSGILSMFAAQAGAKHVYAVEASE-MAEYARKLI 225
Cdd:COG4076   1 DYLMQFFVprwHHPMLNDVERNDAFKAAIE--RVVKPGDVVLDIGTGSGLLSMLAARAGAKKVYAVEVNPdIAAVARRII 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680066 226 AGNPLfADRITVIKGKVEDIELPEKADILISEPMGTLLVNERMLESYVIARDRFMTPKGKMFPTVGRIHMAPfsdeflfI 305
Cdd:COG4076  79 AANGL-SDRITVINADATDLDLPEKADVIISEMLDTALLDEGQVPILNHARKRLLKPGGRIIPERITNAAQP-------V 150

                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 30680066 306 EMANKAMFWQQQNYYGVDltpLYGSAHQGYFSQPVVDAFDPRL 348
Cdd:COG4076 151 ESPVDAEGFEDWQFDGFD---FRLFGFLLYAEPLLHLTRLVRT 190
 
Name Accession Description Interval E-value
COG4076 COG4076
Predicted RNA methylase [General function prediction only];
150-348 2.17e-45

Predicted RNA methylase [General function prediction only];


Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 159.43  E-value: 2.17e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680066 150 HYYGQLLH---QQNMLQDYVRTGTYYAAVMenHSDFAGRVVVDVGAGSGILSMFAAQAGAKHVYAVEASE-MAEYARKLI 225
Cdd:COG4076   1 DYLMQFFVprwHHPMLNDVERNDAFKAAIE--RVVKPGDVVLDIGTGSGLLSMLAARAGAKKVYAVEVNPdIAAVARRII 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680066 226 AGNPLfADRITVIKGKVEDIELPEKADILISEPMGTLLVNERMLESYVIARDRFMTPKGKMFPTVGRIHMAPfsdeflfI 305
Cdd:COG4076  79 AANGL-SDRITVINADATDLDLPEKADVIISEMLDTALLDEGQVPILNHARKRLLKPGGRIIPERITNAAQP-------V 150

                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 30680066 306 EMANKAMFWQQQNYYGVDltpLYGSAHQGYFSQPVVDAFDPRL 348
Cdd:COG4076 151 ESPVDAEGFEDWQFDGFD---FRLFGFLLYAEPLLHLTRLVRT 190
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 187-264 2.54e-11

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 60.52  E-value: 2.54e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680066 187 VVDVGAGSGILSMFAAQAGAKHVYAVEASE-MAEYARKLIAGnpLFADRITVIKGKVEDIEL--PEKADILISEPMGTLL 263
Cdd:cd02440   2 VLDLGCGTGALALALASGPGARVTGVDISPvALELARKAAAA--LLADNVEVLKGDAEELPPeaDESFDVIISDPPLHHL 79


                .
gi 30680066 264 V 264
Cdd:cd02440  80 V 80
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 187-256 3.67e-10

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 56.80  E-value: 3.67e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 30680066   187 VVDVGAGSGILSMFAAQAGAKHVYAVEASE-MAEYARKLIAGNPLfadRITVIKGKVEDIELP-EKADILIS 256
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGGARVTGVDLSPeMLERARERAAEAGL---NVEFVQGDAEDLPFPdGSFDLVVS 69
prmA PRK00517
50S ribosomal protein L11 methyltransferase;
181-255 1.00e-06

50S ribosomal protein L11 methyltransferase;


Pssm-ID: 234786 [Multi-domain]  Cd Length: 250  Bit Score: 50.15  E-value: 1.00e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 30680066  181 DFAGRVVVDVGAGSGILSMFAAQAGAKHVYAVEASEMA-EYARKLIAGNPLfadritvikgkVEDIELPE---KADILI 255
Cdd:PRK00517 117 VLPGKTVLDVGCGSGILAIAAAKLGAKKVLAVDIDPQAvEAARENAELNGV-----------ELNVYLPQgdlKADVIV 184
fkbM_fam TIGR01444
methyltransferase, FkbM family; Members of this family are characterized by two well-conserved ...
 186-230 5.51e-05

methyltransferase, FkbM family; Members of this family are characterized by two well-conserved short regions separated by a variable in both sequence and length. The first of the two regions is found in a large number of proteins outside this subfamily, a number of which have been characterized as methyltransferases. One member of the present family, FkbM, was shown to be required for a specific methylation in the biosynthesis of the immunosuppressant FK506 in Streptomyces strain MA6548.


Pssm-ID: 273628  Cd Length: 143  Bit Score: 43.45  E-value: 5.51e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 30680066   186 VVVDVGAGSGILSMFAAQAGAK-HVYAVEAS-EMAEYARKLIAGNPL 230
Cdd:TIGR01444   1 VVIDVGANIGDTSLYFARKGAEgRVIAFEPLpDAYEILEENVKLNNL 47
rADc smart00650
Ribosomal RNA adenine dimethylases;
184-255 5.87e-03

Ribosomal RNA adenine dimethylases;


Pssm-ID: 128898  Cd Length: 169  Bit Score: 37.88  E-value: 5.87e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 30680066    184 GRVVVDVGAGSGILSMFAAQAGAKhVYAVEA-SEMAEYARKLIAGnplfADRITVIKGKVEDIELPEKADILI 255
Cdd:smart00650  14 GDTVLEIGPGKGALTEELLERAKR-VTAIEIdPRLAPRLREKFAA----ADNLTVIHGDALKFDLPKLQPYKV 81
 
Name Accession Description Interval E-value
COG4076 COG4076
Predicted RNA methylase [General function prediction only];
150-348 2.17e-45

Predicted RNA methylase [General function prediction only];


Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 159.43  E-value: 2.17e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680066 150 HYYGQLLH---QQNMLQDYVRTGTYYAAVMenHSDFAGRVVVDVGAGSGILSMFAAQAGAKHVYAVEASE-MAEYARKLI 225
Cdd:COG4076   1 DYLMQFFVprwHHPMLNDVERNDAFKAAIE--RVVKPGDVVLDIGTGSGLLSMLAARAGAKKVYAVEVNPdIAAVARRII 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680066 226 AGNPLfADRITVIKGKVEDIELPEKADILISEPMGTLLVNERMLESYVIARDRFMTPKGKMFPTVGRIHMAPfsdeflfI 305
Cdd:COG4076  79 AANGL-SDRITVINADATDLDLPEKADVIISEMLDTALLDEGQVPILNHARKRLLKPGGRIIPERITNAAQP-------V 150

                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 30680066 306 EMANKAMFWQQQNYYGVDltpLYGSAHQGYFSQPVVDAFDPRL 348
Cdd:COG4076 151 ESPVDAEGFEDWQFDGFD---FRLFGFLLYAEPLLHLTRLVRT 190
COG2263 COG2263
Predicted RNA methylase [General function prediction only];
181-258 5.59e-12

Predicted RNA methylase [General function prediction only];


Pssm-ID: 441864 [Multi-domain]  Cd Length: 199  Bit Score: 64.93  E-value: 5.59e-12
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 30680066 181 DFAGRVVVDVGAGSGILSMFAAQAGAKHVYAVEASE-MAEYARKLIagnPLFADRITVIKGKVEDIELPEKADILISEP 258
Cdd:COG2263  43 DIEGKTVLDLGCGTGMLAIGAALLGAKKVVGVDIDPeALEIARENA---ERLGVRVDFIRADVTRIPLGGSVDTVVMNP 118
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 187-264 2.54e-11

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 60.52  E-value: 2.54e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680066 187 VVDVGAGSGILSMFAAQAGAKHVYAVEASE-MAEYARKLIAGnpLFADRITVIKGKVEDIEL--PEKADILISEPMGTLL 263
Cdd:cd02440   2 VLDLGCGTGALALALASGPGARVTGVDISPvALELARKAAAA--LLADNVEVLKGDAEELPPeaDESFDVIISDPPLHHL 79


                .
gi 30680066 264 V 264
Cdd:cd02440  80 V 80
PrmA COG2264
Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];
181-255 3.71e-11

Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441865 [Multi-domain]  Cd Length: 284  Bit Score: 64.04  E-value: 3.71e-11
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 30680066 181 DFAGRVVVDVGAGSGILSMFAAQAGAKHVYAVEASEMA-EYARKLIAGNPLfADRITVIKGkveDIELPEKADILI 255
Cdd:COG2264 146 LKPGKTVLDVGCGSGILAIAAAKLGAKRVLAVDIDPVAvEAARENAELNGV-EDRIEVVLG---DLLEDGPYDLVV 217
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 183-262 3.22e-10

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 57.72  E-value: 3.22e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680066 183 AGRVVVDVGAGSGILSMFAAQAGAkHVYAVEASE-MAEYARKLIAgnplfADRITVIKGKVEDIELP-EKADILISepMG 260
Cdd:COG2227  24 AGGRVLDVGCGTGRLALALARRGA-DVTGVDISPeALEIARERAA-----ELNVDFVQGDLEDLPLEdGSFDLVIC--SE 95


                ..
gi 30680066 261 TL 262
Cdd:COG2227  96 VL 97
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 187-256 3.67e-10

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 56.80  E-value: 3.67e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 30680066   187 VVDVGAGSGILSMFAAQAGAKHVYAVEASE-MAEYARKLIAGNPLfadRITVIKGKVEDIELP-EKADILIS 256
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGGARVTGVDLSPeMLERARERAAEAGL---NVEFVQGDAEDLPFPdGSFDLVVS 69
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 183-258 6.09e-10

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 59.77  E-value: 6.09e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680066 183 AGRVVVDVGAGSGILSMFAAQ-AGAKHVYAVEASE-MAEYARKLIAGNPLfADRITVIKGKVEDIE---LPEKADILISE 257
Cdd:COG4123  37 KGGRVLDLGTGTGVIALMLAQrSPGARITGVEIQPeAAELARRNVALNGL-EDRITVIHGDLKEFAaelPPGSFDLVVSN 115


                .
gi 30680066 258 P 258
Cdd:COG4123 116 P 116
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 183-256 1.68e-08

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 53.78  E-value: 1.68e-08
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 30680066 183 AGRVVVDVGAGSGILSMFAAQAGAKHVYAVEAS-EMAEYARKLIAGNPLfADRITVIKGKVEDIELPEKADILIS 256
Cdd:COG2230  51 PGMRVLDIGCGWGGLALYLARRYGVRVTGVTLSpEQLEYARERAAEAGL-ADRVEVRLADYRDLPADGQFDAIVS 124
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 172-256 1.94e-08

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 53.07  E-value: 1.94e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680066 172 YAAVMENHSDFAGRVVVDVGAGSGILSMFAAQAGAkHVYAVEAS-EMAEYARKLIAGNPLfadRITVIKGKVEDIELPEK 250
Cdd:COG2226  11 REALLAALGLRPGARVLDLGCGTGRLALALAERGA-RVTGVDISpEMLELARERAAEAGL---NVEFVVGDAEDLPFPDG 86


                ....*..
gi 30680066 251 A-DILIS 256
Cdd:COG2226  87 SfDLVIS 93
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
183-256 2.08e-08

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 51.75  E-value: 2.08e-08
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 30680066 183 AGRVVVDVGAGSGILS-MFAAQAGAKHVYAVEAS-EMAEYARKLiagnplfADRITVIKGKVEDIELPEKADILIS 256
Cdd:COG4106   1 PPRRVLDLGCGTGRLTaLLAERFPGARVTGVDLSpEMLARARAR-------LPNVRFVVADLRDLDPPEPFDLVVS 69
prmA PRK00517
50S ribosomal protein L11 methyltransferase;
181-255 1.00e-06

50S ribosomal protein L11 methyltransferase;


Pssm-ID: 234786 [Multi-domain]  Cd Length: 250  Bit Score: 50.15  E-value: 1.00e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 30680066  181 DFAGRVVVDVGAGSGILSMFAAQAGAKHVYAVEASEMA-EYARKLIAGNPLfadritvikgkVEDIELPE---KADILI 255
Cdd:PRK00517 117 VLPGKTVLDVGCGSGILAIAAAKLGAKKVLAVDIDPQAvEAARENAELNGV-----------ELNVYLPQgdlKADVIV 184
PrmA pfam06325
Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal ...
 183-255 1.33e-06

Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal protein L11 methyltransferase (EC:2.1.1.-) sequences.


Pssm-ID: 428888 [Multi-domain]  Cd Length: 294  Bit Score: 50.34  E-value: 1.33e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 30680066   183 AGRVVVDVGAGSGILSMFAAQAGAKHVYAVEASEMA-EYARKLIAGNPLfADRITVikgKVEDIELPEKADILI 255
Cdd:pfam06325 161 PGESVLDVGCGSGILAIAALKLGAKKVVGVDIDPVAvRAAKENAELNGV-EARLEV---YLPGDLPKEKADVVV 230
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 183-258 3.72e-06

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 47.49  E-value: 3.72e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 30680066 183 AGRVVVDVGAGSGILSMFAAQAGAK-HVYAVEASEMA-EYARKLIAGNPLfaDRITVIKGKV-EDIElPEKADILISEP 258
Cdd:COG2813  49 LGGRVLDLGCGYGVIGLALAKRNPEaRVTLVDVNARAvELARANAAANGL--ENVEVLWSDGlSGVP-DGSFDLILSNP 124
Gcd14 COG2519
tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 ...
 182-255 1.11e-05

tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 N-methylase Trm61 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442009 [Multi-domain]  Cd Length: 249  Bit Score: 47.08  E-value: 1.11e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 30680066 182 FAGRVVVDVGAGSGILSMFAAQA-GAK-HVYAVEASE-MAEYARKLIAgNPLFADRITVIKGKVEDIELPEKADILI 255
Cdd:COG2519  90 FPGARVLEAGTGSGALTLALARAvGPEgKVYSYERREdFAEIARKNLE-RFGLPDNVELKLGDIREGIDEGDVDAVF 165
TrmA COG2265
tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure ...
 172-255 1.30e-05

tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure and biogenesis]; tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 441866 [Multi-domain]  Cd Length: 377  Bit Score: 47.48  E-value: 1.30e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680066 172 YAAVMENHSDFAGRVVVDVGAGSGILSMFAAQAgAKHVYAVEAS-EMAEYARKLIAGNPLfaDRITVIKGKVEDI----E 246
Cdd:COG2265 222 YAAALEWLDLTGGERVLDLYCGVGTFALPLARR-AKKVIGVEIVpEAVEDARENARLNGL--KNVEFVAGDLEEVlpelL 298


                ....*....
gi 30680066 247 LPEKADILI 255
Cdd:COG2265 299 WGGRPDVVV 307
ksgA PRK14896
16S ribosomal RNA methyltransferase A;
184-256 1.59e-05

16S ribosomal RNA methyltransferase A;


Pssm-ID: 237852 [Multi-domain]  Cd Length: 258  Bit Score: 46.43  E-value: 1.59e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 30680066  184 GRVVVDVGAGSGILSMFAAQAgAKHVYAVEASE-MAEYARKLIAGnplfADRITVIKGKVEDIELPEkADILIS 256
Cdd:PRK14896  30 GDPVLEIGPGKGALTDELAKR-AKKVYAIELDPrLAEFLRDDEIA----AGNVEIIEGDALKVDLPE-FNKVVS 97
HemK COG2890
Methylase of polypeptide chain release factors [Translation, ribosomal structure and ...
 174-258 2.59e-05

Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis];


Pssm-ID: 442135 [Multi-domain]  Cd Length: 282  Bit Score: 45.91  E-value: 2.59e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680066 174 AVMENHSDFAGRVVVDVGAGSGI--LSMFAAQAGAkHVYAVEASEMA-EYARKLIAGNPLfADRITVIKGKV-EDIELPE 249
Cdd:COG2890 103 LALALLPAGAPPRVLDLGTGSGAiaLALAKERPDA-RVTAVDISPDAlAVARRNAERLGL-EDRVRFLQGDLfEPLPGDG 180


                ....*....
gi 30680066 250 KADILISEP 258
Cdd:COG2890 181 RFDLIVSNP 189
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 188-256 3.53e-05

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 42.65  E-value: 3.53e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 30680066   188 VDVGAGSGILSMFAAQAGAkHVYAVEAS-EMAEYARKLIAGNPLfadriTVIKGKVEDIELPEKA-DILIS 256
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGA-RVTGVDISpEMLELAREKAPREGL-----TFVVGDAEDLPFPDNSfDLVLS 65
fkbM_fam TIGR01444
methyltransferase, FkbM family; Members of this family are characterized by two well-conserved ...
 186-230 5.51e-05

methyltransferase, FkbM family; Members of this family are characterized by two well-conserved short regions separated by a variable in both sequence and length. The first of the two regions is found in a large number of proteins outside this subfamily, a number of which have been characterized as methyltransferases. One member of the present family, FkbM, was shown to be required for a specific methylation in the biosynthesis of the immunosuppressant FK506 in Streptomyces strain MA6548.


Pssm-ID: 273628  Cd Length: 143  Bit Score: 43.45  E-value: 5.51e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 30680066   186 VVVDVGAGSGILSMFAAQAGAK-HVYAVEAS-EMAEYARKLIAGNPL 230
Cdd:TIGR01444   1 VVIDVGANIGDTSLYFARKGAEgRVIAFEPLpDAYEILEENVKLNNL 47
FtsJ pfam01728
FtsJ-like methyltransferase; This family consists of FtsJ from various bacterial and archaeal ...
 184-256 1.30e-04

FtsJ-like methyltransferase; This family consists of FtsJ from various bacterial and archaeal sources FtsJ is a methyltransferase, but actually has no effect on cell division. FtsJ's substrate is the 23S rRNA. The 1.5 A crystal structure of FtsJ in complex with its cofactor S-adenosylmethionine revealed that FtsJ has a methyltransferase fold. This family also includes the N terminus of flaviviral NS5 protein. It has been hypothesized that the N-terminal domain of NS5 is a methyltransferase involved in viral RNA capping.


Pssm-ID: 426399  Cd Length: 179  Bit Score: 42.96  E-value: 1.30e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680066   184 GRVVVDVGAGSGILSMFAAQAGAKHVYAVEASEMAEYArkliagnPLFADRITVIKGKVEDIE--------LPEKADILI 255
Cdd:pfam01728  22 GKTVLDLGAAPGGWSQVALQRGAGKVVGVDLGPMQLWK-------PRNDPGVTFIQGDIRDPEtldlleelLGRKVDLVL 94


                  .
gi 30680066   256 S 256
Cdd:pfam01728  95 S 95
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 184-287 1.30e-04

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 42.58  E-value: 1.30e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680066   184 GRVVVDVGAGSGILSMFAAQAGAK-HVYAVEASEMA-EYARKLIAGNPLfaDRITVIKGKVEDIELPEKADILISEP--- 258
Cdd:pfam05175  32 SGKVLDLGCGAGVLGAALAKESPDaELTMVDINARAlESARENLAANGL--ENGEVVASDVYSGVEDGKFDLIISNPpfh 109

                          90       100       110
                  ....*....|....*....|....*....|..
gi 30680066   259 ---MGTLLVNERMLESyviARdRFMTPKGKMF 287
Cdd:pfam05175 110 aglATTYNVAQRFIAD---AK-RHLRPGGELW 137
PRK14967 PRK14967
putative methyltransferase; Provisional
 184-258 1.51e-04

putative methyltransferase; Provisional


Pssm-ID: 184931 [Multi-domain]  Cd Length: 223  Bit Score: 43.12  E-value: 1.51e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 30680066  184 GRVVVDVGAGSGILSMFAAQAGAKHVYAVEASEMA-EYARkliaGNPLFAD-RITVIKGKVEDIELPEKADILISEP 258
Cdd:PRK14967  37 GRRVLDLCTGSGALAVAAAAAGAGSVTAVDISRRAvRSAR----LNALLAGvDVDVRRGDWARAVEFRPFDVVVSNP 109
PRMT5 pfam05185
PRMT5 arginine-N-methyltransferase; The human homolog of yeast Skb1 (Shk1 kinase-binding ...
 186-266 1.55e-04

PRMT5 arginine-N-methyltransferase; The human homolog of yeast Skb1 (Shk1 kinase-binding protein 1) is PRMT5, an arginine-N-methyltransferase. These proteins appear to be key mitotic regulators. They play a role in Jak signalling in higher eukaryotes.


Pssm-ID: 428356  Cd Length: 171  Bit Score: 42.58  E-value: 1.55e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680066   186 VVVDVGAGSGIL---SMFAAQ-AGAK-HVYAVEASEMA-EYARKLIAgNPLFADRITVIKGKVEDIELPEKADILISEPM 259
Cdd:pfam05185  66 VILVVGAGRGPLvdrALRAAEeTGTKvKIYAVEKNPNAyVTLQKRIN-FEKWGDKVTIISSDMREWQGPEKADILVSELL 144


                  ....*..
gi 30680066   260 GTLLVNE 266
Cdd:pfam05185 145 GSFGDNE 151
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
148-256 1.66e-04

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 42.68  E-value: 1.66e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680066 148 YFHYYGQLLHQQNmlqDYVRTGTYYAAVMENHSDFAGRVVVDVGAGSGILSMFAAQAGaKHVYAVEASE-MAEYARKLIA 226
Cdd:COG4976  14 YADSYDAALVEDL---GYEAPALLAEELLARLPPGPFGRVLDLGCGTGLLGEALRPRG-YRLTGVDLSEeMLAKAREKGV 89

                        90       100       110
                ....*....|....*....|....*....|
gi 30680066 227 GNPLFADRITvikgkvEDIELPEKADILIS 256
Cdd:COG4976  90 YDRLLVADLA------DLAEPDGRFDLIVA 113
CobL COG2242
Precorrin-6B methylase 2 [Coenzyme transport and metabolism]; Precorrin-6B methylase 2 is part ...
 183-249 7.17e-04

Precorrin-6B methylase 2 [Coenzyme transport and metabolism]; Precorrin-6B methylase 2 is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 441843 [Multi-domain]  Cd Length: 403  Bit Score: 42.08  E-value: 7.17e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 30680066 183 AGRVVVDVGAGSGILSMFAAQAGAK-HVYAVEASEMaeyARKLIAGNplfADR-----ITVIKGKVEDI--ELPE 249
Cdd:COG2242 247 PGDVLWDIGAGSGSVSIEAARLAPGgRVYAIERDPE---RAALIRAN---ARRfgvpnVEVVEGEAPEAlaDLPD 315
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 187-284 8.60e-04

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 40.67  E-value: 8.60e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680066 187 VVDVGAGSGILSMFAAQAGAKHVYAVEAS-EMAEYARKLIAGNPLfaDRITVIKGKVEDIE--LPEKADILISepMGTL- 262
Cdd:COG0500  30 VLDLGCGTGRNLLALAARFGGRVIGIDLSpEAIALARARAAKAGL--GNVEFLVADLAELDplPAESFDLVVA--FGVLh 105

                        90       100
                ....*....|....*....|..
gi 30680066 263 LVNERMLESYVIARDRFMTPKG 284
Cdd:COG0500 106 HLPPEEREALLRELARALKPGG 127
PRK07580 PRK07580
Mg-protoporphyrin IX methyl transferase; Validated
 176-246 1.13e-03

Mg-protoporphyrin IX methyl transferase; Validated


Pssm-ID: 236059 [Multi-domain]  Cd Length: 230  Bit Score: 40.59  E-value: 1.13e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 30680066  176 MENHSDFAGRVVVDVGAGSGILSMFAAQAGAKhVYAVEASE-MAEYARK-----LIAGNPLFAdritvikgkVEDIE 246
Cdd:PRK07580  56 LPADGDLTGLRILDAGCGVGSLSIPLARRGAK-VVASDISPqMVEEARErapeaGLAGNITFE---------VGDLE 122
YqxC COG1189
Predicted rRNA methylase YqxC, contains S4 and FtsJ domains [Translation, ribosomal structure ...
 181-212 3.35e-03

Predicted rRNA methylase YqxC, contains S4 and FtsJ domains [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440802 [Multi-domain]  Cd Length: 248  Bit Score: 39.27  E-value: 3.35e-03
                        10        20        30
                ....*....|....*....|....*....|..
gi 30680066 181 DFAGRVVVDVGAGSGILSMFAAQAGAKHVYAV 212
Cdd:COG1189  75 DVAGKVCLDIGASTGGFTDCLLQRGAAKVYAV 106
PRK09328 PRK09328
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional
 174-258 3.74e-03

N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional


Pssm-ID: 236467 [Multi-domain]  Cd Length: 275  Bit Score: 39.37  E-value: 3.74e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680066  174 AVMENHSDFAGRVVVDVGAGSGILS-MFAAQAGAKHVYAVEASEMA-EYARKliagN--PLFADRITVIKGKV-EDIElP 248
Cdd:PRK09328  99 WALEALLLKEPLRVLDLGTGSGAIAlALAKERPDAEVTAVDISPEAlAVARR----NakHGLGARVEFLQGDWfEPLP-G 173

                         90
                 ....*....|
gi 30680066  249 EKADILISEP 258
Cdd:PRK09328 174 GRFDLIVSNP 183
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 186-256 3.81e-03

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 38.17  E-value: 3.81e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 30680066   186 VVVDVGAGSGILSMFAAQ--AGAKHVYAVEASE-MAEYARKLIAGNPLfaDRITVIKGKVEDIEL---PEKADILIS 256
Cdd:pfam13847   6 RVLDLGCGTGHLSFELAEelGPNAEVVGIDISEeAIEKARENAQKLGF--DNVEFEQGDIEELPElleDDKFDVVIS 80
PRK14968 PRK14968
putative methyltransferase; Provisional
 176-240 4.14e-03

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 38.34  E-value: 4.14e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 30680066  176 MENHSDFAGRVVVDVGAGSGILSMFAAQAGAKhVYAVEASEMA-EYARKLIAGNPLFADRITVIKG 240
Cdd:PRK14968  16 AENAVDKKGDRVLEVGTGSGIVAIVAAKNGKK-VVGVDINPYAvECAKCNAKLNNIRNNGVEVIRS 80
RsmA COG0030
16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase ...
 183-240 4.19e-03

16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase/AP lyase activity) [Translation, ribosomal structure and biogenesis]; 16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase/AP lyase activity) is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 439801 [Multi-domain]  Cd Length: 270  Bit Score: 39.34  E-value: 4.19e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 30680066 183 AGRVVVDVGAGSGILSMFAAQAgAKHVYAVEA-SEMAEYARKLIAGNPlfadRITVIKG 240
Cdd:COG0030  37 PGDTVLEIGPGLGALTRALLER-AARVTAVEIdRRLAAILRETFAAYP----NLTVIEG 90
rADc smart00650
Ribosomal RNA adenine dimethylases;
184-255 5.87e-03

Ribosomal RNA adenine dimethylases;


Pssm-ID: 128898  Cd Length: 169  Bit Score: 37.88  E-value: 5.87e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 30680066    184 GRVVVDVGAGSGILSMFAAQAGAKhVYAVEA-SEMAEYARKLIAGnplfADRITVIKGKVEDIELPEKADILI 255
Cdd:smart00650  14 GDTVLEIGPGKGALTEELLERAKR-VTAIEIdPRLAPRLREKFAA----ADNLTVIHGDALKFDLPKLQPYKV 81
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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