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    PLDDELTA phospholipase D delta [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 829733, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PLDDELTA
    Official Full Name
    phospholipase D delta
    Primary source
    TAIR:AT4G35790
    Locus tag
    AT4G35790
    See related
    Araport:AT4G35790
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS THALIANA PHOSPHOLIPASE D DELTA; ATPLDDELTA; F4B14.60; F4B14_60; PHOSPHOLIPASE D; phospholipase D delta
    Summary
    Encodes a protein with phospholipase D activity. Involved in phospolipase metabolism. Mutants are affected in hydrogen peroxide mediated cell death.
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    Genomic context

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    See PLDDELTA in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    10
    Sequence:
    Chromosome: 4; NC_003075.7 (16955415..16960407, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene RNA-binding (RRM/RBD/RNP motifs) family protein Neighboring gene ROTUNDIFOLIA like 6 Neighboring gene RNA polymerase II large subunit Neighboring gene 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The plasma membrane-bound phospholipase Ddelta enhances freezing tolerance in Arabidopsis thaliana. Li W, et al. Nat Biotechnol, 2004 Apr. PMID 15004566
    2. Phospholipase Dδ regulates pollen tube growth by modulating actin cytoskeleton organization in Arabidopsis. Jia Q, et al. Plant Signal Behav, 2021 Jul 3. PMID 33853512, Free PMC Article
    3. Osmotic stress-triggered stomatal closure requires Phospholipase Dδ and hydrogen sulfide in Arabidopsis thaliana. Liu Q, et al. Biochem Biophys Res Commun, 2021 Jan 1. PMID 33187643
    4. Involvement of Arabidopsis phospholipase D δ in regulation of ROS-mediated microtubule organization and stomatal movement upon heat shock. Song P, et al. J Exp Bot, 2020 Oct 22. PMID 32725150
    5. Secretion of Phospholipase Dδ Functions as a Regulatory Mechanism in Plant Innate Immunity. Xing J, et al. Plant Cell, 2019 Dec. PMID 31597687, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Populus euphratica GLABRA3 Binds PLDdelta Promoters to Enhance Salt Tolerance.
      Title: Populus euphratica GLABRA3 Binds PLDδ Promoters to Enhance Salt Tolerance.
    2. Phosphatidic acid modulates MPK3- and MPK6-mediated hypoxia signaling in Arabidopsis.
      Title: Phosphatidic acid modulates MPK3- and MPK6-mediated hypoxia signaling in Arabidopsis.
    3. Phospholipase Ddelta regulates pollen tube growth by modulating actin cytoskeleton organization in Arabidopsis.
      Title: Phospholipase Dδ regulates pollen tube growth by modulating actin cytoskeleton organization in Arabidopsis.
    4. Involvement of Arabidopsis phospholipase D delta in regulation of ROS-mediated microtubule organization and stomatal movement upon heat shock.
      Title: Involvement of Arabidopsis phospholipase D δ in regulation of ROS-mediated microtubule organization and stomatal movement upon heat shock.
    5. Osmotic stress-triggered stomatal closure requires Phospholipase Ddelta and hydrogen sulfide in Arabidopsis thaliana.
      Title: Osmotic stress-triggered stomatal closure requires Phospholipase Dδ and hydrogen sulfide in Arabidopsis thaliana.
    6. The translocation of PLDdelta to papillae is modulated by exocytosis, thus triggering phosphatidic acid-mediated signaling in plant innate immunity.
      Title: Secretion of Phospholipase Dδ Functions as a Regulatory Mechanism in Plant Innate Immunity.
    7. The results demonstrate that PLDalpha1 and PLDdelta oppositely modulate basal, post-penetration resistance against powdery mildew through a non-canonical mechanism that is independent of EDS1/PAD4, SA, and JA.
      Title: Arabidopsis phospholipase Dα1 and Dδ oppositely modulate EDS1- and SA-independent basal resistance against adapted powdery mildew.
    8. PLDdelta negatively regulates plant thermotolerance via destabilizing cortical microtubules.
      Title: Phospholipase Dδ negatively regulates plant thermotolerance by destabilizing cortical microtubules in Arabidopsis.
    9. in wt plants PLDdelta disrupt membranes in severe drought stress and, in the absence of the protein (PLDdelta knock-out) might drought-prime the plants, making them more tolerant to severe drought stress.
      Title: Phospholipase D δ knock-out mutants are tolerant to severe drought stress.
    10. PLD is involved in defense signaling in nonhost resistance against powdery mildew fungi and PLDdelta is the main isoform participating in this process.
      Title: Arabidopsis phospholipase dδ is involved in basal defense and nonhost resistance to powdery mildew fungi.
    Submit: New GeneRIF Correction See all GeneRIFs (15)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_119745.3
    NM_179170.3
    NM_179171.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables N-acylphosphatidylethanolamine-specific phospholipase D activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phospholipase D activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phospholipase D activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phospholipase D activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables phospholipase D activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within phosphatidic acid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phosphatidylcholine metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of abscisic acid-activated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within programmed cell death IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of stomatal closure IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to cold IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to cold IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    colocalizes_with microtubule cytoskeleton TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in plant cell papilla IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plant-type vacuole HDA PubMed 
    located_in plasma membrane HDA PubMed 
    colocalizes_with plasma membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in plasma membrane region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasmodesma HDA PubMed 

    General protein information

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    Preferred Names
    phospholipase D delta
    NP_567989.1
    • phospholipase D delta (PLDDELTA); FUNCTIONS IN: phospholipase D activity; INVOLVED IN: response to water deprivation, response to cold, hyperosmotic salinity response, phosphatidic acid metabolic process, programmed cell death; LOCATED IN: microtubule cytoskeleton, plasma membrane, vacuole, membrane; EXPRESSED IN: 31 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: C2 membrane targeting protein (InterPro:IPR018029), C2 calcium/lipid-binding domain, CaLB (InterPro:IPR008973), Phospholipase D (InterPro:IPR015679), Phospholipase D, plant (InterPro:IPR011402), Phospholipase D/Transphosphatidylase (InterPro:IPR001736), C2 calcium-dependent membrane targeting (InterPro:IPR000008); BEST Arabidopsis thaliana protein match is: phospholipase D beta 1 (TAIR:AT2G42010.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
    NP_849501.1
    • ARABIDOPSIS THALIANA PHOSPHOLIPASE D DELTA (ATPLDDELTA); FUNCTIONS IN: phospholipase D activity; INVOLVED IN: response to water deprivation, response to cold, hyperosmotic salinity response, phosphatidic acid metabolic process, programmed cell death; LOCATED IN: microtubule cytoskeleton, plasma membrane, vacuole, membrane; EXPRESSED IN: 31 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: C2 membrane targeting protein (InterPro:IPR018029), C2 calcium/lipid-binding domain, CaLB (InterPro:IPR008973), Phospholipase D (InterPro:IPR015679), Phospholipase D, plant (InterPro:IPR011402), Phospholipase D/Transphosphatidylase (InterPro:IPR001736), C2 calcium-dependent membrane targeting (InterPro:IPR000008); BEST Arabidopsis thaliana protein match is: phospholipase D beta 1 (TAIR:AT2G42010.1); Has 2426 Blast hits to 1986 proteins in 434 species: Archae - 0; Bacteria - 499; Metazoa - 513; Fungi - 443; Plants - 789; Viruses - 0; Other Eukaryotes - 182 (source: NCBI BLink).
    NP_849502.1
    • ARABIDOPSIS THALIANA PHOSPHOLIPASE D DELTA (ATPLDDELTA); FUNCTIONS IN: phospholipase D activity; INVOLVED IN: response to water deprivation, response to cold, hyperosmotic salinity response, phosphatidic acid metabolic process, programmed cell death; LOCATED IN: microtubule cytoskeleton, plasma membrane, vacuole, membrane; EXPRESSED IN: 31 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: C2 membrane targeting protein (InterPro:IPR018029), C2 calcium/lipid-binding domain, CaLB (InterPro:IPR008973), Phospholipase D (InterPro:IPR015679), Phospholipase D, plant (InterPro:IPR011402), Phospholipase D/Transphosphatidylase (InterPro:IPR001736), C2 calcium-dependent membrane targeting (InterPro:IPR000008); BEST Arabidopsis thaliana protein match is: phospholipase D beta 1 (TAIR:AT2G42010.1); Has 2145 Blast hits to 1885 proteins in 404 species: Archae - 0; Bacteria - 362; Metazoa - 509; Fungi - 323; Plants - 775; Viruses - 0; Other Eukaryotes - 176 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      16955415..16960407 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_179170.3 → NP_849501.1  phospholipase D delta [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_849501.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UUU1
      Conserved Domains (1) summary
      PLN03008
      Location:1 → 857
      PLN03008; Phospholipase D delta

    2. NM_179171.2 → NP_849502.1  phospholipase D delta [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_849502.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F4JNU6
      Conserved Domains (2) summary
      cd04015
      Location:9 → 177
      C2_plant_PLD; C2 domain present in plant phospholipase D (PLD)
      cl15239
      Location:231 → 408
      PLDc_SF; Catalytic domain of phospholipase D superfamily proteins

    3. NM_119745.3 → NP_567989.1  phospholipase D delta [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_567989.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0WUE7, Q8L891, Q944P8, Q947R2, Q9C5Y0, Q9FS18, Q9SZS7
      UniProtKB/TrEMBL
      A0A5S9XYZ0
      Conserved Domains (1) summary
      PLN03008
      Location:1 → 868
      PLN03008; Phospholipase D delta
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9C5Y0.2

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