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    pgp-9 P-GlycoProtein related [ Caenorhabditis elegans ]

    Gene ID: 180165, updated on 9-Dec-2024

    Summary

    Official Symbol
    pgp-9
    Official Full Name
    P-GlycoProtein related
    Primary source
    WormBase:WBGene00004003
    Locus tag
    CELE_C47A10.1
    See related
    AllianceGenome:WB:WBGene00004003
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ATPase-coupled transmembrane transporter activity and efflux transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in plasma membrane. Predicted to be active in membrane. Is expressed in intestine; nervous system; and pharynx. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); cholestasis (multiple); drug dependence (multiple); and human immunodeficiency virus infectious disease (multiple). Orthologous to several human genes including ABCB1 (ATP binding cassette subfamily B member 1); ABCB4 (ATP binding cassette subfamily B member 4); and ABCB5 (ATP binding cassette subfamily B member 5). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See pgp-9 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    11
    Sequence:
    Chromosome: V; NC_003283.11 (17755892..17764751)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Conjugal transfer protein TraR Neighboring gene tRNA Neighboring gene Serpentine Receptor, class H

    Interactions

    General gene information

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ABC-type transporter activity  
    enables ATP binding  
    enables ATP hydrolysis activity  
    enables ATPase-coupled transmembrane transporter activity  
    enables efflux transmembrane transporter activity  
    Process Evidence Code Pubs
    involved_in response to chemical  
    involved_in siderophore transmembrane transport  
    involved_in siderophore-dependent iron import into cell  
    involved_in transmembrane transport  
    involved_in transmembrane transport  
    Component Evidence Code Pubs
    is_active_in membrane  
    located_in membrane  
    located_in plasma membrane  

    General protein information

    Preferred Names
    P-GlycoProtein related
    NP_507487.1
    • Product from WormBase gene class pgp;
      Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      17755892..17764751
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_075086.6NP_507487.1  P-GlycoProtein related [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_507487.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EG58
      Conserved Domains (3) summary
      cd03249
      Location:10301269
      ABC_MTABC3_MDL1_MDL2; ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins
      PTZ00265
      Location:281262
      PTZ00265; multidrug resistance protein (mdr1); Provisional
      pfam00664
      Location:50334
      ABC_membrane; ABC transporter transmembrane region
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