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    Lrrc27 leucine rich repeat containing 27 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 499281, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Lrrc27provided by RGD
    Official Full Name
    leucine rich repeat containing 27provided by RGD
    Primary source
    RGD:1559981
    See related
    EnsemblRapid:ENSRNOG00000017538 AllianceGenome:RGD:1559981
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1559981
    Summary
    Predicted to enable actin binding activity. Predicted to be involved in cardiac muscle cell development. Predicted to be active in cytoskeleton and sarcomere. Orthologous to human LRRC27 (leucine rich repeat containing 27). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 273.5) and Heart (RPKM 29.8) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Lrrc27 in Genome Data Viewer
    Location:
    1q41
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (203433463..203464683)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (194004967..194035087)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (211543751..211575823)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene dihydropyrimidinase-like 4 Neighboring gene serine/threonine kinase 32C Neighboring gene uncharacterized LOC120099954 Neighboring gene PWWP domain containing 2B Neighboring gene uncharacterized LOC134485192 Neighboring gene uncharacterized LOC134485193

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    General protein information

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    Preferred Names
    leucine-rich repeat-containing protein 27

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001113789.2 → NP_001107261.2  leucine-rich repeat-containing protein 27 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has a distinct 3' coding region compared to variant 1. The resulting isoform (b) has a shorter and distinct C-terminus, compared to isoform a.
      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A6HXB1, D3ZDV5
      Conserved Domains (3) summary
      sd00031
      Location:50 → 69
      LRR_1; leucine-rich repeat [structural motif]
      pfam13855
      Location:68 → 127
      LRR_8; Leucine rich repeat
      cl26793
      Location:30 → 173
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

    2. NM_001143756.2 → NP_001137228.1  leucine-rich repeat-containing protein 27 isoform a

      See identical proteins and their annotated locations for NP_001137228.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      BC158629, JAXUCZ010000001
      UniProtKB/TrEMBL
      B0BN00
      Related
      ENSRNOP00000099036.1, ENSRNOT00000125021.1
      Conserved Domains (3) summary
      PLN00113
      Location:30 → 173
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      sd00031
      Location:50 → 69
      LRR_1; leucine-rich repeat [structural motif]
      pfam13855
      Location:68 → 127
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      203433463..203464683
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039087869.2 → XP_038943797.1  leucine-rich repeat-containing protein 27 isoform X1

      UniProtKB/TrEMBL
      B0BN00
      Conserved Domains (3) summary
      PLN00113
      Location:30 → 173
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      sd00031
      Location:50 → 69
      LRR_1; leucine-rich repeat [structural motif]
      pfam13855
      Location:68 → 127
      LRR_8; Leucine rich repeat

    2. XM_063271537.1 → XP_063127607.1  leucine-rich repeat-containing protein 27 isoform X1

      UniProtKB/TrEMBL
      B0BN00

    3. XM_063271539.1 → XP_063127609.1  leucine-rich repeat-containing protein 27 isoform X2

      UniProtKB/TrEMBL
      A6HXB1

    4. XM_063271541.1 → XP_063127611.1  leucine-rich repeat-containing protein 27 isoform X3

      UniProtKB/TrEMBL
      A6HXB1, D3ZDV5

    5. XM_063271548.1 → XP_063127618.1  leucine-rich repeat-containing protein 27 isoform X3

      UniProtKB/TrEMBL
      A6HXB1, D3ZDV5
      Related
      ENSRNOP00000048246.3, ENSRNOT00000049631.6

    6. XM_063271536.1 → XP_063127606.1  leucine-rich repeat-containing protein 27 isoform X1

      UniProtKB/TrEMBL
      B0BN00
      Related
      ENSRNOP00000023610.4, ENSRNOT00000023610.9

    7. XM_063271545.1 → XP_063127615.1  leucine-rich repeat-containing protein 27 isoform X3

      UniProtKB/TrEMBL
      A6HXB1, D3ZDV5
    Nucleotide Protein Strain
    Heading Accession and Version

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