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Conserved domains on  [gi|1958648811|ref|XP_038943797|]
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leucine-rich repeat-containing protein 27 isoform X1 [Rattus norvegicus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
50-156 2.58e-18

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 86.91  E-value: 2.58e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648811  50 ILDLSQKGLRHLGK-FFKIPNLQQLHLQRNLLSEIPQDFFQLlPNLTWLDLRYNKIRVLPPGIGSHKHLKTLLLERNPIK 128
Cdd:COG4886   140 ELDLSNNQLTDLPEpLGNLTNLKSLDLSNNQLTDLPEELGNL-TNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLT 218

                          90       100
                  ....*....|....*....|....*...
gi 1958648811 129 ALPVELGQVTTLTALNLRHCPLEFPPYL 156
Cdd:COG4886   219 DLPEPLANLTNLETLDLSNNQLTDLPEL 246
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
50-156 2.58e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 86.91  E-value: 2.58e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648811  50 ILDLSQKGLRHLGK-FFKIPNLQQLHLQRNLLSEIPQDFFQLlPNLTWLDLRYNKIRVLPPGIGSHKHLKTLLLERNPIK 128
Cdd:COG4886   140 ELDLSNNQLTDLPEpLGNLTNLKSLDLSNNQLTDLPEELGNL-TNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLT 218

                          90       100
                  ....*....|....*....|....*...
gi 1958648811 129 ALPVELGQVTTLTALNLRHCPLEFPPYL 156
Cdd:COG4886   219 DLPEPLANLTNLETLDLSNNQLTDLPEL 246
LRR_8 pfam13855
Leucine rich repeat;
68-127 1.92e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 59.08  E-value: 1.92e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958648811  68 PNLQQLHLQRNLLSEIPQDFFQLLPNLTWLDLRYNKIRVLPPGIGSH-KHLKTLLLERNPI 127
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGlPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 51-127 6.74e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 47.09  E-value: 6.74e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958648811  51 LDLSQKGLRHLGKFFKIPNLQQLHLQRNLLSEIPQdfFQLLPNLTWLDLRYNKIRVLpPGIGSHKHLKTLLLERNPI 127
Cdd:cd21340     7 LYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKI-ENLENLVNLKKLYLGGNRI 80
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 30-173 4.37e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 42.91  E-value: 4.37e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648811  30 SFSRDNDQVDFEGVIYSSSP---ILDLSQKGLRhlGK----FFKIPNLQQLHLQRNLLS-EIPQDFFQLLPNLTWLDLRY 101
Cdd:PLN00113   50 NWNSSADVCLWQGITCNNSSrvvSIDLSGKNIS--GKissaIFRLPYIQTINLSNNQLSgPIPDDIFTTSSSLRYLNLSN 127

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958648811 102 NKIRVLPPGiGSHKHLKTLLLERNPIKA-LPVELGQVTTLTALNLRHCPL--EFPPYLivqkGLVSILTFLRICS 173
Cdd:PLN00113  128 NNFTGSIPR-GSIPNLETLDLSNNMLSGeIPNDIGSFSSLKVLDLGGNVLvgKIPNSL----TNLTSLEFLTLAS 197
LRR smart00370
Leucine-rich repeats, outliers;
91-114 1.83e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 35.79  E-value: 1.83e-03
                           10        20
                   ....*....|....*....|....
gi 1958648811   91 LPNLTWLDLRYNKIRVLPPGIGSH 114
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
50-156 2.58e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 86.91  E-value: 2.58e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648811  50 ILDLSQKGLRHLGK-FFKIPNLQQLHLQRNLLSEIPQDFFQLlPNLTWLDLRYNKIRVLPPGIGSHKHLKTLLLERNPIK 128
Cdd:COG4886   140 ELDLSNNQLTDLPEpLGNLTNLKSLDLSNNQLTDLPEELGNL-TNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLT 218

                          90       100
                  ....*....|....*....|....*...
gi 1958648811 129 ALPVELGQVTTLTALNLRHCPLEFPPYL 156
Cdd:COG4886   219 DLPEPLANLTNLETLDLSNNQLTDLPEL 246
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
25-151 6.71e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 79.59  E-value: 6.71e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648811  25 KSLPDSFSRDNDQVDFEGVIYSSSPILDLSQKGLRHLGKFFKIPNLQQLHLQRNLLSEIPQDFFQLlPNLTWLDLRYNKI 104
Cdd:COG4886    70 SLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLPEELANL-TNLKELDLSNNQL 148

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1958648811 105 RVLPPGIGSHKHLKTLLLERNPIKALPVELGQVTTLTALNLRHCPLE 151
Cdd:COG4886   149 TDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQIT 195
LRR_8 pfam13855
Leucine rich repeat;
68-127 1.92e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 59.08  E-value: 1.92e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958648811  68 PNLQQLHLQRNLLSEIPQDFFQLLPNLTWLDLRYNKIRVLPPGIGSH-KHLKTLLLERNPI 127
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGlPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
51-239 5.14e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 61.49  E-value: 5.14e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648811  51 LDLSQKGLRHLGKFF-KIPNLQQLHLQRNLLSEIPQdfFQLLPNLTWLDLRYNKIRVLPPgIGSHKHLKTLLLERNPIKA 129
Cdd:COG4886   210 LDLSGNQLTDLPEPLaNLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPP-LANLTNLKTLDLSNNQLTD 286

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648811 130 LpvelgQVTTLTALNLRHCPLEFPPYLIVQKGLVSILTFLRICSVENAFPGDESLPGVPTAKSDLLLPLPHKDLSSENGL 209
Cdd:COG4886   287 L-----KLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSL 361

                         170       180       190
                  ....*....|....*....|....*....|
gi 1958648811 210 NVLDQEAAVVKEKGDFFPPMDRLDLSELRK 239
Cdd:COG4886   362 LLTLLLTLGLLGLLEATLLTLALLLLTLLL 391
LRR_8 pfam13855
Leucine rich repeat;
50-104 4.97e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 46.75  E-value: 4.97e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958648811  50 ILDLSQKGLRHLGK--FFKIPNLQQLHLQRNLLSEIPQDFFQLLPNLTWLDLRYNKI 104
Cdd:pfam13855   5 SLDLSNNRLTSLDDgaFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 51-127 6.74e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 47.09  E-value: 6.74e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958648811  51 LDLSQKGLRHLGKFFKIPNLQQLHLQRNLLSEIPQdfFQLLPNLTWLDLRYNKIRVLpPGIGSHKHLKTLLLERNPI 127
Cdd:cd21340     7 LYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKI-ENLENLVNLKKLYLGGNRI 80
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 68-124 1.12e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 46.70  E-value: 1.12e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958648811  68 PNLQQLHLQRNLLSEIpqDFFQLLPNLTWLDLRYNKIRVLpPGIGSHKHLKTLLLER 124
Cdd:cd21340    46 TNLTHLYLQNNQIEKI--ENLENLVNLKKLYLGGNRISVV-EGLENLTNLEELHIEN 99
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
50-238 7.87e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 44.92  E-value: 7.87e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648811  50 ILDLSQKGLRHLGKFFKIPNLQQLHLQRNLLSEIPQDFFqlLPNLTWLDLRYNKIRVLppgigSHKHLKTLLLERNPIKA 129
Cdd:COG4886   232 TLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLAN--LTNLKTLDLSNNQLTDL-----KLKELELLLGLNSLLLL 304

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648811 130 LPVELGQVTTLTALNLRHCPLEFPPYLIVQKGLVSILTFLRICSVENAFPGDESLPGVPTAKSDLLLPLPHKDLSSENGL 209
Cdd:COG4886   305 LLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLAL 384

                         170       180
                  ....*....|....*....|....*....
gi 1958648811 210 NVLDQEAAVVKEKGDFFPPMDRLDLSELR 238
Cdd:COG4886   385 LLLTLLLLLLTTTAGVLLLTLALLDAVNT 413
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 30-173 4.37e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 42.91  E-value: 4.37e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648811  30 SFSRDNDQVDFEGVIYSSSP---ILDLSQKGLRhlGK----FFKIPNLQQLHLQRNLLS-EIPQDFFQLLPNLTWLDLRY 101
Cdd:PLN00113   50 NWNSSADVCLWQGITCNNSSrvvSIDLSGKNIS--GKissaIFRLPYIQTINLSNNQLSgPIPDDIFTTSSSLRYLNLSN 127

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958648811 102 NKIRVLPPGiGSHKHLKTLLLERNPIKA-LPVELGQVTTLTALNLRHCPL--EFPPYLivqkGLVSILTFLRICS 173
Cdd:PLN00113  128 NNFTGSIPR-GSIPNLETLDLSNNMLSGeIPNDIGSFSSLKVLDLGGNVLvgKIPNSL----TNLTSLEFLTLAS 197
LRR smart00370
Leucine-rich repeats, outliers;
91-114 1.83e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 35.79  E-value: 1.83e-03
                           10        20
                   ....*....|....*....|....
gi 1958648811   91 LPNLTWLDLRYNKIRVLPPGIGSH 114
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
91-114 1.83e-03

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 35.79  E-value: 1.83e-03
                           10        20
                   ....*....|....*....|....
gi 1958648811   91 LPNLTWLDLRYNKIRVLPPGIGSH 114
Cdd:smart00369   1 LPNLRELDLSNNQLSSLPPGAFQG 24
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 50-165 4.66e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 39.83  E-value: 4.66e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648811  50 ILDLSQ-KGLRHLGKFFKIPNLQQLHLQRNLLSE-IPQDFFQlLPNLTWLDLRYNKIR-VLPPGIGSHKHLKTLLLERNP 126
Cdd:PLN00113  456 MLSLARnKFFGGLPDSFGSKRLENLDLSRNQFSGaVPRKLGS-LSELMQLKLSENKLSgEIPDELSSCKKLVSLDLSHNQ 534

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1958648811 127 IKA-LPVELGQVTTLTALNLRHCPL--EFPPYLIVQKGLVSI 165
Cdd:PLN00113  535 LSGqIPASFSEMPVLSQLDLSQNQLsgEIPKNLGNVESLVQV 576
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 50-150 5.77e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 38.88  E-value: 5.77e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958648811  50 ILDLSQKGLRHLGkffkiPNLQQLHLQRNLLSEIPQD----FFQLLPNLTWLDLRYNK-----IRVLPPGIGSHKHLKTL 120
Cdd:cd00116   124 GLRLLAKGLKDLP-----PALEKLVLGRNRLEGASCEalakALRANRDLKELNLANNGigdagIRALAEGLKANCNLEVL 198

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1958648811 121 LLERNPI-----KALPVELGQVTTLTALNLRHCPL 150
Cdd:cd00116   199 DLNNNGLtdegaSALAETLASLKSLEVLNLGDNNL 233
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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