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    Maf1 Maf1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 3354925, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Maf1provided by FlyBase
    Official Full Name
    Maf1provided by FlyBase
    Primary source
    FLYBASE:FBgn0267861
    Locus tag
    Dmel_CG40196
    See related
    AllianceGenome:FB:FBgn0267861
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG40196; CR41604; dMaf1; Dmel\CG40196; Maf; maf1
    Summary
    Predicted to enable RNA polymerase III core binding activity. Involved in negative regulation of transcription by RNA polymerase III. Predicted to be active in nucleus. Orthologous to human MAF1 (MAF1 homolog, negative regulator of RNA polymerase III). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Maf1 in Genome Data Viewer
    Location:
    41A1-41A1; 2-55 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (1512810..1527095, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44042 Neighboring gene long non-coding RNA:CR44043 Neighboring gene lethal (2) 41Ab Neighboring gene Branched chain keto acid dehydrogenase E1 subunit beta Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NT_033778.4 Chromosome 2R Reference Release 6 plus ISO1 MT Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Emerging Roles for Maf1 beyond the Regulation of RNA Polymerase III Activity. Khanna A, et al. J Mol Biol, 2015 Aug 14. PMID 26173035, Free PMC Article
    2. Why should cancer biologists care about tRNAs? tRNA synthesis, mRNA translation and the control of growth. Grewal SS. Biochim Biophys Acta, 2015 Jul. PMID 25497380
    3. Trametinib ameliorates aging-associated gut pathology in Drosophila females by reducing Pol III activity in intestinal stem cells. Ureña E, et al. Proc Natl Acad Sci U S A, 2024 Jan 23. PMID 38241436, Free PMC Article
    4. RNA polymerase III limits longevity downstream of TORC1. Filer D, et al. Nature, 2017 Dec 14. PMID 29186112, Free PMC Article
    5. Nutrient/TOR-dependent regulation of RNA polymerase III controls tissue and organismal growth in Drosophila. Marshall L, et al. EMBO J, 2012 Apr 18. PMID 22367393, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Drosophila RNA polymerase III repressor Maf1 (CG40196) controls body size and developmental timing by modulating tRNAiMet synthesis and systemic insulin signaling.
      Title: Drosophila RNA polymerase III repressor Maf1 controls body size and developmental timing by modulating tRNAiMet synthesis and systemic insulin signaling.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    • Annotated by Drosophila Heterochromatin Genome Project, Lawrence Berkeley National Lab, http://www.dhgp.org

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA polymerase III core binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase III IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase III IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase III IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Maf1
    Names
    CG40196-PA
    CG40196-PB
    CG40196-PC
    CG40196-PD
    CG40196-PE
    Maf1-PA
    Maf1-PB
    Maf1-PC
    Maf1-PD
    Maf1-PE

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      1512810..1527095 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001110544.3 → NP_001104014.1  Maf1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001104014.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NL53, Q7PL26
      Conserved Domains (1) summary
      pfam09174
      Location:25 → 204
      Maf1; Maf1 regulator

    2. NM_001015168.4 → NP_001015168.2  Maf1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001015168.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NL53, Q7PL26
      Conserved Domains (1) summary
      pfam09174
      Location:25 → 204
      Maf1; Maf1 regulator

    3. NM_001300720.1 → NP_001287649.1  Maf1, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287649.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NL53, Q7PL26
      Conserved Domains (1) summary
      pfam09174
      Location:25 → 204
      Maf1; Maf1 regulator

    4. NM_001170411.1 → NP_001163882.1  Maf1, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163882.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NL53, Q7PL26
      Conserved Domains (1) summary
      pfam09174
      Location:25 → 204
      Maf1; Maf1 regulator

    5. NM_001015167.3 → NP_001015167.2  Maf1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001015167.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NL53, Q7PL26
      Conserved Domains (1) summary
      pfam09174
      Location:25 → 204
      Maf1; Maf1 regulator
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7PL26 Q7PL26

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