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Conserved domains on  [gi|160714822|ref|NP_001015168|]
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Maf1, isoform B [Drosophila melanogaster]

Protein Classification

repressor of RNA polymerase III transcription MAF1( domain architecture ID 10557763)

repressor of RNA polymerase III transcription MAF1 plays a role in the repression of RNA polymerase III-mediated transcription in response to changing nutritional, environmental and cellular stress conditions

CATH:  3.40.1000.50
Gene Ontology:  GO:0016480|GO:0000994|GO:0000992

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Maf1 pfam09174
Maf1 regulator; Maf1 is a negative regulator of RNA polymerase III. It targets the initiation ...
25-204 3.39e-86

Maf1 regulator; Maf1 is a negative regulator of RNA polymerase III. It targets the initiation factor TFIIIB.


:

Pssm-ID: 462704  Cd Length: 174  Bit Score: 252.55  E-value: 3.39e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160714822   25 IFGRIESYSCKMVAAEKVLYKRFTAD-------SHGHDLQALS-PPQTLADFSPNFrrnnsqsgdegiTLCDTISRKTLF 96
Cdd:pfam09174   1 ITGRLELYSCKAAGSDKKLYKSIEKElesqyesLLPLSASLSSaPSLNLSSSSPFG------------PLSDTSSRKTLA 68
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160714822   97 YLIATLNASFePDYDFSEAKSHEFSKEPSLQWVMNSIHANLSALAGDkYQAIRQPLWSAVDDEVILSECDIYSYNPDLSC 176
Cdd:pfam09174  69 YLIATLNASF-PDYDFSHLRPDDFSKEPSLRSVMNNIDSTLSNILGD-YSSLRPKLWAAIDEEISLKDCDIYSYNPDDDS 146
                         170       180
                  ....*....|....*....|....*...
gi 160714822  177 DPFGEPGCLWSFNYFFYNKKLKRIVFFT 204
Cdd:pfam09174 147 DPFGEEGALWSFNYFFYNKKLKRVLFFY 174
 
Name Accession Description Interval E-value
Maf1 pfam09174
Maf1 regulator; Maf1 is a negative regulator of RNA polymerase III. It targets the initiation ...
25-204 3.39e-86

Maf1 regulator; Maf1 is a negative regulator of RNA polymerase III. It targets the initiation factor TFIIIB.


Pssm-ID: 462704  Cd Length: 174  Bit Score: 252.55  E-value: 3.39e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160714822   25 IFGRIESYSCKMVAAEKVLYKRFTAD-------SHGHDLQALS-PPQTLADFSPNFrrnnsqsgdegiTLCDTISRKTLF 96
Cdd:pfam09174   1 ITGRLELYSCKAAGSDKKLYKSIEKElesqyesLLPLSASLSSaPSLNLSSSSPFG------------PLSDTSSRKTLA 68
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160714822   97 YLIATLNASFePDYDFSEAKSHEFSKEPSLQWVMNSIHANLSALAGDkYQAIRQPLWSAVDDEVILSECDIYSYNPDLSC 176
Cdd:pfam09174  69 YLIATLNASF-PDYDFSHLRPDDFSKEPSLRSVMNNIDSTLSNILGD-YSSLRPKLWAAIDEEISLKDCDIYSYNPDDDS 146
                         170       180
                  ....*....|....*....|....*...
gi 160714822  177 DPFGEPGCLWSFNYFFYNKKLKRIVFFT 204
Cdd:pfam09174 147 DPFGEEGALWSFNYFFYNKKLKRVLFFY 174
MAF1 COG5046
Protein involved in Mod5 protein sorting [Posttranslational modification, protein turnover, ...
91-202 6.88e-19

Protein involved in Mod5 protein sorting [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227379  Cd Length: 282  Bit Score: 82.74  E-value: 6.88e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160714822  91 SRKTLFYLIATLNASFePDYDFSEAKSHEFSKEPSLQWVMNSIHANLsalagdkYQAIRQPL-----WSAVDDEVILSEC 165
Cdd:COG5046  130 SRSKFNYLFAKLNASY-PDHDFSSEAPTDFSKRRSLGRFVEKPLGTL-------LSAGRLRFpydfcWESIGSHRRLSDC 201
                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 160714822 166 DIYSYNPDLSCDPFGEPGCLWSFNYFFYNKKLKRIVF 202
Cdd:COG5046  202 EVLNYMPYSISTTHKNSDDVWEFVGFLENILHKRVSY 238
 
Name Accession Description Interval E-value
Maf1 pfam09174
Maf1 regulator; Maf1 is a negative regulator of RNA polymerase III. It targets the initiation ...
25-204 3.39e-86

Maf1 regulator; Maf1 is a negative regulator of RNA polymerase III. It targets the initiation factor TFIIIB.


Pssm-ID: 462704  Cd Length: 174  Bit Score: 252.55  E-value: 3.39e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160714822   25 IFGRIESYSCKMVAAEKVLYKRFTAD-------SHGHDLQALS-PPQTLADFSPNFrrnnsqsgdegiTLCDTISRKTLF 96
Cdd:pfam09174   1 ITGRLELYSCKAAGSDKKLYKSIEKElesqyesLLPLSASLSSaPSLNLSSSSPFG------------PLSDTSSRKTLA 68
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160714822   97 YLIATLNASFePDYDFSEAKSHEFSKEPSLQWVMNSIHANLSALAGDkYQAIRQPLWSAVDDEVILSECDIYSYNPDLSC 176
Cdd:pfam09174  69 YLIATLNASF-PDYDFSHLRPDDFSKEPSLRSVMNNIDSTLSNILGD-YSSLRPKLWAAIDEEISLKDCDIYSYNPDDDS 146
                         170       180
                  ....*....|....*....|....*...
gi 160714822  177 DPFGEPGCLWSFNYFFYNKKLKRIVFFT 204
Cdd:pfam09174 147 DPFGEEGALWSFNYFFYNKKLKRVLFFY 174
MAF1 COG5046
Protein involved in Mod5 protein sorting [Posttranslational modification, protein turnover, ...
91-202 6.88e-19

Protein involved in Mod5 protein sorting [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227379  Cd Length: 282  Bit Score: 82.74  E-value: 6.88e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160714822  91 SRKTLFYLIATLNASFePDYDFSEAKSHEFSKEPSLQWVMNSIHANLsalagdkYQAIRQPL-----WSAVDDEVILSEC 165
Cdd:COG5046  130 SRSKFNYLFAKLNASY-PDHDFSSEAPTDFSKRRSLGRFVEKPLGTL-------LSAGRLRFpydfcWESIGSHRRLSDC 201
                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 160714822 166 DIYSYNPDLSCDPFGEPGCLWSFNYFFYNKKLKRIVF 202
Cdd:COG5046  202 EVLNYMPYSISTTHKNSDDVWEFVGFLENILHKRVSY 238
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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