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    MSS1 Major facilitator superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 832703, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MSS1
    Official Full Name
    Major facilitator superfamily protein
    Primary source
    TAIR:AT5G26340
    Locus tag
    AT5G26340
    See related
    Araport:AT5G26340
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATSTP13; F9D12.17; F9D12_17; STP13; SUGAR TRANSPORT PROTEIN 13
    Summary
    Encodes a protein with high affinity, hexose-specific/H+ symporter activity. The activity of the transporter appears to be negatively regulated by phosphorylation. Importantly, microarray analysis, as well as the study of the expression of this gene in mutants involved in programmed cell death (PCD) demonstrated a tight correlation between this gene's expression and PCD.
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    Genomic context

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    See MSS1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    4
    Sequence:
    Chromosome: 5; NC_003076.8 (9243398..9247540, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene TRAF-like family protein Neighboring gene Cupredoxin superfamily protein Neighboring gene pseudo Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transcriptional activation of SUGAR TRANSPORT PROTEIN 13 mediates biotic and abiotic stress signaling. Lee HG, et al. Plant Signal Behav, 2021 Aug 3. PMID 33899679, Free PMC Article
    2. Regulation of sugar transporter activity for antibacterial defense in Arabidopsis. Yamada K, et al. Science, 2016 Dec 16. PMID 27884939
    3. Expression of Arabidopsis sugar transport protein STP13 differentially affects glucose transport activity and basal resistance to Botrytis cinerea. Lemonnier P, et al. Plant Mol Biol, 2014 Jul. PMID 24817131
    4. Over-expression of STP13, a hexose transporter, improves plant growth and nitrogen use in Arabidopsis thaliana seedlings. Schofield RA, et al. Plant Cell Environ, 2009 Mar. PMID 19054349
    5. Expression of the Arabidopsis high-affinity hexose transporter STP13 correlates with programmed cell death. Norholm MH, et al. FEBS Lett, 2006 Apr 17. PMID 16616142

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Transcriptional activation of SUGAR TRANSPORT PROTEIN 13 mediates biotic and abiotic stress signaling.
      Title: Transcriptional activation of SUGAR TRANSPORT PROTEIN 13 mediates biotic and abiotic stress signaling.
    2. Stimulation of STP13 activity suppresses bacterial effector delivery, thereby reducing bacterial virulence.
      Title: Regulation of sugar transporter activity for antibacterial defense in Arabidopsis.
    3. This study showed that STP13-deficient plants exhibited an enhanced susceptibility to B. cinerea and a reduced rate of glucose uptake.
      Title: Expression of Arabidopsis sugar transport protein STP13 differentially affects glucose transport activity and basal resistance to Botrytis cinerea.
    4. The results indicate that STP13 can reabsorb the monosaccharides that are released by damaged cells under high salinity conditions.
      Title: Monosaccharide absorption activity of Arabidopsis roots depends on expression profiles of transporter genes under high salinity conditions.
    5. Transgenic seedlings over-expressing STP13 had increased rates of glucose uptake, higher endogenous sucrose levels, accumulated more total C and biomass per plant, and and had higher levels of expression of the nitrate transporter NRT2.2.
      Title: Over-expression of STP13, a hexose transporter, improves plant growth and nitrogen use in Arabidopsis thaliana seedlings.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_122535.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables carbohydrate transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables hexose:proton symporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables high-affinity D-glucose:proton symporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables monosaccharide transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within monosaccharide transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to abscisic acid IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to salt stress IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to water deprivation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasma membrane HDA PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasmodesma HDA PubMed 
    located_in plastid HDA PubMed 

    General protein information

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    Preferred Names
    Major facilitator superfamily protein
    NP_198006.1
    • MSS1; FUNCTIONS IN: carbohydrate transmembrane transporter activity, high-affinity hydrogen:glucose symporter activity, sugar:hydrogen symporter activity, hexose:hydrogen symporter activity; INVOLVED IN: response to salt stress, apoptosis, phosphorylation; LOCATED IN: plasma membrane, membrane; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 10 growth stages; CONTAINS InterPro DOMAIN/s: Sugar transporter, conserved site (InterPro:IPR005829), Major facilitator superfamily (InterPro:IPR020846), General substrate transporter (InterPro:IPR005828), Sugar/inositol transporter (InterPro:IPR003663), Major facilitator superfamily, general substrate transporter (InterPro:IPR016196); BEST Arabidopsis thaliana protein match is: sugar transporter protein 7 (TAIR:AT4G02050.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      9243398..9247540 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_122535.4 → NP_198006.1  Major facilitator superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_198006.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O81501, Q0WM12, Q94AZ2
      UniProtKB/TrEMBL
      A0A178UHA7, A0A5S9Y7X2
      Conserved Domains (1) summary
      cd17361
      Location:29 → 475
      MFS_STP; Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q94AZ2.2

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