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Conserved domains on  [gi|15240313|ref|NP_198006|]
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Major facilitator superfamily protein [Arabidopsis thaliana]

Protein Classification

sugar porter family MFS transporter( domain architecture ID 13024241)

sugar porter family major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of sugar or polyol substrates such as glucose, galactose, trehalose, and arabinose, among others

CATH:  1.20.1250.20
SCOP:  3000310
TCDB:  2.A.1.1

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MFS_STP cd17361
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; ...
29-475 0e+00

Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; The plant Sugar transport protein (STP) subfamily includes STP1-STP14; they are also called hexose transporters. They mediate the active uptake of hexoses such as glucose, 3-O-methylglucose, fructose, xylose, mannose, galactose, fucose, 2-deoxyglucose and arabinose, by sugar/hydrogen symport. Several STP family transporters are expressed in a tissue-specific manner, or at specific developmental stages. STP1 is the member with the highest expression level of all members and high expression is detected in photosynthetic tissues, such as leaves and stems, while roots, siliques, and flowers show lower expression levels. It plays a major role in the uptake and response of Arabidopsis seeds and seedlings to sugars. The STP subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340919 [Multi-domain]  Cd Length: 390  Bit Score: 609.64  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313  29 MAATGGLMFGYDVGVSGGVTSMPDFLEKFFPVVYRKvvAGADKDSNYCKYDNQGLQLFTSSLYLAGLTATFFASYTTRTL 108
Cdd:cd17361   1 VAALGGLIFGYDIGISGGVTSMDPFLEKFFPSVYEK--KKGASENNYCKYDDQLLQLFTSSLYLAGLVASLLASYVTRKW 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 109 GRRLTMLIAGVFFIIGVALNAGAQDLAMLIAGRILLGCGVGFANQAVPLFLSEIAPTRIRGGLNILFQLNVTIGILFANL 188
Cdd:cd17361  79 GRKPSMLIGGVLFLVGAALNAAAQNIAMLIVGRILLGFGVGFGNQAVPLYLSEMAPAKLRGALNIGFQLAITIGILIANL 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 189 VNYGTAKIKGgWGWRLSLGLAGIPALLLTVGALLVTETPNSlvergrldegkavlrrirgtdnvepefadlleasrlake 268
Cdd:cd17361 159 INYGTSKIKP-NGWRLSLGLAAVPALILLLGSLFLPETPNS--------------------------------------- 198
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 269 vkhpfrnllqrrnrPQLVIAVALQIFQQCTGINAIMFYAPVLFSTLGFGSDASLYSAVVTGAVNVLSTLVSIYSVDKVGR 348
Cdd:cd17361 199 --------------PQLVIAILIPFFQQLTGINVIMFYAPVLFQTLGFGSDASLISAVITGAVNVVSTLVSIYLVDRFGR 264
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 349 RVLLLEAGVQMFFSQVVIAIILGVKVTDTSTnLSKGFAILVVVMICTYVAAFAWSWGPLGWLIPSETFPLETRSAGQSVT 428
Cdd:cd17361 265 RFLLLEGGVQMLASQVAIGILLAVKFGDGGE-LPKAYAIAVVVLICLYVAAFAWSWGPLGWLVPSEIFPLETRSAGQSLT 343
                       410       420       430       440
                ....*....|....*....|....*....|....*....|....*..
gi 15240313 429 VCVNLLFTFIIAQAFLSMLCHFKFGIFIFFSAWVLIMSVFVMFLLPE 475
Cdd:cd17361 344 VAVNFLFTFVIAQAFLSMLCAMKFGIFLFFAGWVVVMSLFVYFLLPE 390
 
Name Accession Description Interval E-value
MFS_STP cd17361
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; ...
29-475 0e+00

Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; The plant Sugar transport protein (STP) subfamily includes STP1-STP14; they are also called hexose transporters. They mediate the active uptake of hexoses such as glucose, 3-O-methylglucose, fructose, xylose, mannose, galactose, fucose, 2-deoxyglucose and arabinose, by sugar/hydrogen symport. Several STP family transporters are expressed in a tissue-specific manner, or at specific developmental stages. STP1 is the member with the highest expression level of all members and high expression is detected in photosynthetic tissues, such as leaves and stems, while roots, siliques, and flowers show lower expression levels. It plays a major role in the uptake and response of Arabidopsis seeds and seedlings to sugars. The STP subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340919 [Multi-domain]  Cd Length: 390  Bit Score: 609.64  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313  29 MAATGGLMFGYDVGVSGGVTSMPDFLEKFFPVVYRKvvAGADKDSNYCKYDNQGLQLFTSSLYLAGLTATFFASYTTRTL 108
Cdd:cd17361   1 VAALGGLIFGYDIGISGGVTSMDPFLEKFFPSVYEK--KKGASENNYCKYDDQLLQLFTSSLYLAGLVASLLASYVTRKW 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 109 GRRLTMLIAGVFFIIGVALNAGAQDLAMLIAGRILLGCGVGFANQAVPLFLSEIAPTRIRGGLNILFQLNVTIGILFANL 188
Cdd:cd17361  79 GRKPSMLIGGVLFLVGAALNAAAQNIAMLIVGRILLGFGVGFGNQAVPLYLSEMAPAKLRGALNIGFQLAITIGILIANL 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 189 VNYGTAKIKGgWGWRLSLGLAGIPALLLTVGALLVTETPNSlvergrldegkavlrrirgtdnvepefadlleasrlake 268
Cdd:cd17361 159 INYGTSKIKP-NGWRLSLGLAAVPALILLLGSLFLPETPNS--------------------------------------- 198
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 269 vkhpfrnllqrrnrPQLVIAVALQIFQQCTGINAIMFYAPVLFSTLGFGSDASLYSAVVTGAVNVLSTLVSIYSVDKVGR 348
Cdd:cd17361 199 --------------PQLVIAILIPFFQQLTGINVIMFYAPVLFQTLGFGSDASLISAVITGAVNVVSTLVSIYLVDRFGR 264
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 349 RVLLLEAGVQMFFSQVVIAIILGVKVTDTSTnLSKGFAILVVVMICTYVAAFAWSWGPLGWLIPSETFPLETRSAGQSVT 428
Cdd:cd17361 265 RFLLLEGGVQMLASQVAIGILLAVKFGDGGE-LPKAYAIAVVVLICLYVAAFAWSWGPLGWLVPSEIFPLETRSAGQSLT 343
                       410       420       430       440
                ....*....|....*....|....*....|....*....|....*..
gi 15240313 429 VCVNLLFTFIIAQAFLSMLCHFKFGIFIFFSAWVLIMSVFVMFLLPE 475
Cdd:cd17361 344 VAVNFLFTFVIAQAFLSMLCAMKFGIFLFFAGWVVVMSLFVYFLLPE 390
Sugar_tr pfam00083
Sugar (and other) transporter;
27-486 4.25e-120

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 360.82  E-value: 4.25e-120
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313    27 CIMAATGGLMFGYDVGVSGGVTSMPDFLEKFfpvvyrkvvaGADKDSNYCKYDNQGLQLFTSSLYLAGLTATFFASYTTR 106
Cdd:pfam00083   2 ALVAALGGFLFGYDTGVIGAFLTLIDFFKNF----------GLSKSVSSLAALSVLSGLIVSIFSVGCFIGSLFAGKLGD 71
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313   107 TLGRRLTMLIAGVFFIIGVALNAGAQDLA---MLIAGRILLGCGVGFANQAVPLFLSEIAPTRIRGGLNILFQLNVTIGI 183
Cdd:pfam00083  72 RFGRKKSLLIANVLFVIGAVLQGAAKGKWsvyQLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQLAITFGI 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313   184 LFANLVNYGTAKIKGGWGWRLSLGLAGIPALLLTVGALLVTETPNSLVERGRLDEGKAVLRRIRGTDNVEPEFADLLEAS 263
Cdd:pfam00083 152 LLAYIFGLGLNKTSNSDGWRIPLGLQLVPALLLIIGLLFLPESPRWLVEKGRLEEAREVLAKLRGVPDVDRELDEIKDSL 231
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313   264 -RLAKEVKHPFRNLLQRRNRPQ-LVIAVALQIFQQCTGINAIMFYAPVLFSTLGFgsDASLYSAVVTGAVNVLSTLVSIY 341
Cdd:pfam00083 232 eAGQEAEKASWKELFSTKTRRQrLLIGVMLQIFQQLTGINAIFYYSTTIFENLGL--SDSFLVTIIVGVVNFVFTFIAIF 309
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313   342 SVDKVGRRVLLLEAGVQMFFSQVVIAIilgvkVTDTSTNLSKGFAILVVVMICTYVAAFAWSWGPLGWLIPSETFPLETR 421
Cdd:pfam00083 310 LVDRFGRRPLLLLGAAGMAICFVILGI-----VALLGVSKSDWAGIVAIVFIALFIAFFAMGWGPVPWVIVSELFPLSVR 384
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15240313   422 SAGQSVTVCVNLLFTFIIAQAFLSMLCHFK-FGIFIFFSAWVLIMSVFVMFLLPETKNIPIEEMTE 486
Cdd:pfam00083 385 SKAMALATAANWLANFLIGFLFPIITDAIGlGYTFFIFAGLLVLFIIFVFFFVPETKGRTLEEIDE 450
SP TIGR00879
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ...
27-484 2.41e-114

MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273317 [Multi-domain]  Cd Length: 481  Bit Score: 347.02  E-value: 2.41e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313    27 CIMAATGGLMFGYDVGVSGGVTSMPDFLEKFFPVvyrkvvagadkdsNYCKYDNQGLQLFTSSLYLAGLTATFFASYTTR 106
Cdd:TIGR00879  30 SLIAAIGGLMFGYDTGVIGGALALPAFEFKFTSA-------------NSDSYSSSLWGLVVSIFLVGGFIGALFAGWLSD 96
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313   107 TLGRRLTMLIAGVFFIIGVALN---AGAQDLAMLIAGRILLGCGVGFANQAVPLFLSEIAPTRIRGGLNILFQLNVTIGI 183
Cdd:TIGR00879  97 RFGRKKSLLIIALLFVIGAILMglaAFALSVEMLIVGRVLLGIGVGIASALVPMYLSEIAPKALRGALTSLYQLAITFGI 176
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313   184 LFANLVNYGTAKIKGGWGWRLSLGLAGIPALLLTVGALLVTETPNSLVERGRLDEGKAVLRRIRGTDNVEPEFADLLEAS 263
Cdd:TIGR00879 177 LVAYGFGSGKVSLNNTLGWRIPLGLQLIPAGLLFLGLFFLPESPRWLVGKGRVEEARKSLARLRGTSGEDKELLDELELI 256
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313   264 RLAKEVKHPFRNL-------LQRRNRPQLVIAVALQIFQQCTGINAIMFYAPVLFSTLGFGSDASLYSAVVTGAVNVLST 336
Cdd:TIGR00879 257 DIKRSIEKRSVQPswgslfsSTRRIRRRLFLGVVLQWFQQFTGINAIMYYSPTIFENAGVSTDHAFLVSIIVGAVNFAFT 336
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313   337 LVSIYSVDKVGRRVLLLEAGVQMFFSQVVIAIILGVKVTDTSTNLSKGFailvVVMICTYVAAFAWSWGPLGWLIPSETF 416
Cdd:TIGR00879 337 FVAIFLVDRFGRRPLLLIGAAGMAICLFVLGILGASFVTGSSKSSGNVA----IVFILLFIAFFAMGWGPVPWVIVSEIF 412
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15240313   417 PLETRSAGQSVTVCVNLLFTFIIAQAFLSMLCHFKFG-IFIFFSAWVLIMSVFVMFLLPETKNIPIEEM 484
Cdd:TIGR00879 413 PLSLRPKGISIAVAANWLANFIVGFLFPTMLESIGVGgVFIFFGGLNVLGLIFVYFFLPETKGRTLEEI 481
xylE PRK10077
D-xylose transporter XylE; Provisional
24-491 1.04e-61

D-xylose transporter XylE; Provisional


Pssm-ID: 182225 [Multi-domain]  Cd Length: 479  Bit Score: 209.93  E-value: 1.04e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313   24 IISCIMAAT-GGLMFGYDVGV-SGGVTSmpdfLEKFFpvvyrkvVAGADKDSNYCKydnqGLQLFTSSLYLAG-LTATFF 100
Cdd:PRK10077  10 IFSITLVATlGGLLFGYDTAViSGTVES----LNTVF-------VAPQNLSESAAN----SLLGFCVASALIGcIIGGAL 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313  101 ASYTTRTLGRRLTMLIAGVFFIIGvALNA----------GAQDLAMLIA---GRILLGCGVGFANQAVPLFLSEIAPTRI 167
Cdd:PRK10077  75 GGYCSNRFGRRDSLKIAAVLFFIS-ALGSawpefgftsiGPDNTGYVPEfviYRIIGGIGVGLASMLSPMYIAEIAPAHI 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313  168 RGGLNILFQLNVTIGILFANLVNYGTAKIKGG-W----GWRLSLGLAGIPALLLTVGALLVTETPNSLVERGRLDEGKAV 242
Cdd:PRK10077 154 RGKLVSFNQFAIIFGQLVVYFVNYFIARSGDAsWlntdGWRYMFASEAIPALLFLMLLYFVPETPRYLMSRGKQEQAEGI 233
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313  243 LRRIRGTDNVEPEFADLLEASRLAKEVKHPfrnlLQRRNRPQLVIAVALQIFQQCTGINAIMFYAPVLFSTLGFGSDASL 322
Cdd:PRK10077 234 LRKIMGNTLATQALQEIKHSLDHGRKTGGK----LLMFGVGVIVIGVMLSVFQQFVGINVVLYYAPEIFKTLGASTDIAL 309
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313  323 YSAVVTGAVNVLSTLVSIYSVDKVGRRVLLLEAGVQMFFSQVVIAIILgvkvtdtSTNLSkgfAILVVVMICTYVAAFAW 402
Cdd:PRK10077 310 LQTIIVGVINLTFTVLAIMTVDKFGRKPLQIIGALGMAIGMFSLGTAF-------YTQAP---GIVALLSMLFYVAAFAM 379
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313  403 SWGPLGWLIPSETFPLETRSAGQSVTVCVNLLFTFIIAQAFLSM------LCHFKFGififFSAWVL-IMSV----FVMF 471
Cdd:PRK10077 380 SWGPVCWVLLSEIFPNAIRGKALAIAVAAQWIANYFVSWTFPMMdknswlVAHFHNG----FSYWIYgCMGVlaalFMWK 455
                        490       500
                 ....*....|....*....|
gi 15240313  472 LLPETKNIPIEEMtERVWKK 491
Cdd:PRK10077 456 FVPETKGKTLEEM-EALWEP 474
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
83-427 1.75e-16

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 80.79  E-value: 1.75e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313  83 LQLFTSSLYLAGLTATFFASYTTRTLGRRLTMLIAGVFFIIGVALNAGAQDLAMLIAGRILLGCGVGFANQAVPLFLSEI 162
Cdd:COG2814  47 AGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADL 126
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 163 APTRIRGGLNILFQLNVTIGILFANLVNYGtakIKGGWGWRLSLGLAGIPALLLTVGALLVTetPNSLVERgrldegkav 242
Cdd:COG2814 127 VPPERRGRALGLLGAGLGLGPALGPLLGGL---LADLFGWRWVFLVNAVLALLALLLLLRLL--PESRPAA--------- 192
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 243 lrrirgtdnvepefadlleASRLAKEVKHPFRnllqrrnRPQLVIAVALQIFQQCTGINAIMFYAPVLFSTLGFGSDASL 322
Cdd:COG2814 193 -------------------RARLRGSLRELLR-------RPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAG 246
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 323 YSAVVTGAVNVLSTLVSIYSVDKVGRRVLLLEAGVQMFFSQVVIAIILGvkvtdtstnlskgfaiLVVVMICTYVAAFAW 402
Cdd:COG2814 247 LLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGS----------------LWLLLLALFLLGFGF 310
                       330       340
                ....*....|....*....|....*.
gi 15240313 403 S-WGPLGWLIPSETFPLETRSAGQSV 427
Cdd:COG2814 311 GlLFPLLQALVAELAPPEARGRASGL 336
 
Name Accession Description Interval E-value
MFS_STP cd17361
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; ...
29-475 0e+00

Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; The plant Sugar transport protein (STP) subfamily includes STP1-STP14; they are also called hexose transporters. They mediate the active uptake of hexoses such as glucose, 3-O-methylglucose, fructose, xylose, mannose, galactose, fucose, 2-deoxyglucose and arabinose, by sugar/hydrogen symport. Several STP family transporters are expressed in a tissue-specific manner, or at specific developmental stages. STP1 is the member with the highest expression level of all members and high expression is detected in photosynthetic tissues, such as leaves and stems, while roots, siliques, and flowers show lower expression levels. It plays a major role in the uptake and response of Arabidopsis seeds and seedlings to sugars. The STP subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340919 [Multi-domain]  Cd Length: 390  Bit Score: 609.64  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313  29 MAATGGLMFGYDVGVSGGVTSMPDFLEKFFPVVYRKvvAGADKDSNYCKYDNQGLQLFTSSLYLAGLTATFFASYTTRTL 108
Cdd:cd17361   1 VAALGGLIFGYDIGISGGVTSMDPFLEKFFPSVYEK--KKGASENNYCKYDDQLLQLFTSSLYLAGLVASLLASYVTRKW 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 109 GRRLTMLIAGVFFIIGVALNAGAQDLAMLIAGRILLGCGVGFANQAVPLFLSEIAPTRIRGGLNILFQLNVTIGILFANL 188
Cdd:cd17361  79 GRKPSMLIGGVLFLVGAALNAAAQNIAMLIVGRILLGFGVGFGNQAVPLYLSEMAPAKLRGALNIGFQLAITIGILIANL 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 189 VNYGTAKIKGgWGWRLSLGLAGIPALLLTVGALLVTETPNSlvergrldegkavlrrirgtdnvepefadlleasrlake 268
Cdd:cd17361 159 INYGTSKIKP-NGWRLSLGLAAVPALILLLGSLFLPETPNS--------------------------------------- 198
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 269 vkhpfrnllqrrnrPQLVIAVALQIFQQCTGINAIMFYAPVLFSTLGFGSDASLYSAVVTGAVNVLSTLVSIYSVDKVGR 348
Cdd:cd17361 199 --------------PQLVIAILIPFFQQLTGINVIMFYAPVLFQTLGFGSDASLISAVITGAVNVVSTLVSIYLVDRFGR 264
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 349 RVLLLEAGVQMFFSQVVIAIILGVKVTDTSTnLSKGFAILVVVMICTYVAAFAWSWGPLGWLIPSETFPLETRSAGQSVT 428
Cdd:cd17361 265 RFLLLEGGVQMLASQVAIGILLAVKFGDGGE-LPKAYAIAVVVLICLYVAAFAWSWGPLGWLVPSEIFPLETRSAGQSLT 343
                       410       420       430       440
                ....*....|....*....|....*....|....*....|....*..
gi 15240313 429 VCVNLLFTFIIAQAFLSMLCHFKFGIFIFFSAWVLIMSVFVMFLLPE 475
Cdd:cd17361 344 VAVNFLFTFVIAQAFLSMLCAMKFGIFLFFAGWVVVMSLFVYFLLPE 390
Sugar_tr pfam00083
Sugar (and other) transporter;
27-486 4.25e-120

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 360.82  E-value: 4.25e-120
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313    27 CIMAATGGLMFGYDVGVSGGVTSMPDFLEKFfpvvyrkvvaGADKDSNYCKYDNQGLQLFTSSLYLAGLTATFFASYTTR 106
Cdd:pfam00083   2 ALVAALGGFLFGYDTGVIGAFLTLIDFFKNF----------GLSKSVSSLAALSVLSGLIVSIFSVGCFIGSLFAGKLGD 71
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313   107 TLGRRLTMLIAGVFFIIGVALNAGAQDLA---MLIAGRILLGCGVGFANQAVPLFLSEIAPTRIRGGLNILFQLNVTIGI 183
Cdd:pfam00083  72 RFGRKKSLLIANVLFVIGAVLQGAAKGKWsvyQLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQLAITFGI 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313   184 LFANLVNYGTAKIKGGWGWRLSLGLAGIPALLLTVGALLVTETPNSLVERGRLDEGKAVLRRIRGTDNVEPEFADLLEAS 263
Cdd:pfam00083 152 LLAYIFGLGLNKTSNSDGWRIPLGLQLVPALLLIIGLLFLPESPRWLVEKGRLEEAREVLAKLRGVPDVDRELDEIKDSL 231
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313   264 -RLAKEVKHPFRNLLQRRNRPQ-LVIAVALQIFQQCTGINAIMFYAPVLFSTLGFgsDASLYSAVVTGAVNVLSTLVSIY 341
Cdd:pfam00083 232 eAGQEAEKASWKELFSTKTRRQrLLIGVMLQIFQQLTGINAIFYYSTTIFENLGL--SDSFLVTIIVGVVNFVFTFIAIF 309
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313   342 SVDKVGRRVLLLEAGVQMFFSQVVIAIilgvkVTDTSTNLSKGFAILVVVMICTYVAAFAWSWGPLGWLIPSETFPLETR 421
Cdd:pfam00083 310 LVDRFGRRPLLLLGAAGMAICFVILGI-----VALLGVSKSDWAGIVAIVFIALFIAFFAMGWGPVPWVIVSELFPLSVR 384
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15240313   422 SAGQSVTVCVNLLFTFIIAQAFLSMLCHFK-FGIFIFFSAWVLIMSVFVMFLLPETKNIPIEEMTE 486
Cdd:pfam00083 385 SKAMALATAANWLANFLIGFLFPIITDAIGlGYTFFIFAGLLVLFIIFVFFFVPETKGRTLEEIDE 450
SP TIGR00879
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ...
27-484 2.41e-114

MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273317 [Multi-domain]  Cd Length: 481  Bit Score: 347.02  E-value: 2.41e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313    27 CIMAATGGLMFGYDVGVSGGVTSMPDFLEKFFPVvyrkvvagadkdsNYCKYDNQGLQLFTSSLYLAGLTATFFASYTTR 106
Cdd:TIGR00879  30 SLIAAIGGLMFGYDTGVIGGALALPAFEFKFTSA-------------NSDSYSSSLWGLVVSIFLVGGFIGALFAGWLSD 96
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313   107 TLGRRLTMLIAGVFFIIGVALN---AGAQDLAMLIAGRILLGCGVGFANQAVPLFLSEIAPTRIRGGLNILFQLNVTIGI 183
Cdd:TIGR00879  97 RFGRKKSLLIIALLFVIGAILMglaAFALSVEMLIVGRVLLGIGVGIASALVPMYLSEIAPKALRGALTSLYQLAITFGI 176
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313   184 LFANLVNYGTAKIKGGWGWRLSLGLAGIPALLLTVGALLVTETPNSLVERGRLDEGKAVLRRIRGTDNVEPEFADLLEAS 263
Cdd:TIGR00879 177 LVAYGFGSGKVSLNNTLGWRIPLGLQLIPAGLLFLGLFFLPESPRWLVGKGRVEEARKSLARLRGTSGEDKELLDELELI 256
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313   264 RLAKEVKHPFRNL-------LQRRNRPQLVIAVALQIFQQCTGINAIMFYAPVLFSTLGFGSDASLYSAVVTGAVNVLST 336
Cdd:TIGR00879 257 DIKRSIEKRSVQPswgslfsSTRRIRRRLFLGVVLQWFQQFTGINAIMYYSPTIFENAGVSTDHAFLVSIIVGAVNFAFT 336
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313   337 LVSIYSVDKVGRRVLLLEAGVQMFFSQVVIAIILGVKVTDTSTNLSKGFailvVVMICTYVAAFAWSWGPLGWLIPSETF 416
Cdd:TIGR00879 337 FVAIFLVDRFGRRPLLLIGAAGMAICLFVLGILGASFVTGSSKSSGNVA----IVFILLFIAFFAMGWGPVPWVIVSEIF 412
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15240313   417 PLETRSAGQSVTVCVNLLFTFIIAQAFLSMLCHFKFG-IFIFFSAWVLIMSVFVMFLLPETKNIPIEEM 484
Cdd:TIGR00879 413 PLSLRPKGISIAVAANWLANFIVGFLFPTMLESIGVGgVFIFFGGLNVLGLIFVYFFLPETKGRTLEEI 481
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
30-475 1.04e-93

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 289.86  E-value: 1.04e-93
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313  30 AATGGLMFGYDVGVSGGVTSmpdFLEKFFPvvyrkvvagadkdsnyCKYDNQGLQLFTSSLYLAGLTATFFASYTTRTLG 109
Cdd:cd17315   2 AALGGLLFGYDLGVINGALL---YIAKDLG----------------FGLSTSLQGLVVSSLLLGAAIGSLFGGPLADRFG 62
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 110 RRLTMLIAGVFFIIGVALNAGAQDLAMLIAGRILLGCGVGFANQAVPLFLSEIAPTRIRGGLNILFQLNVTIGILFANLV 189
Cdd:cd17315  63 RRKSLLIAAVLYVIGALLSALAPNVWVLIVGRFLLGLGVGLASVLVPLYISEIAPAKIRGALGTLNQLMITFGILLAYLL 142
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 190 NYGTAKIKGGWgWRLSLGLAGIPALLLtvgALLVTETPNSLVergrldegkavlrrirgtdnvepefadlleasrlakev 269
Cdd:cd17315 143 GLALSLSPPGW-WRLMFALAAVPALLQ---LLLMFFLPESRA-------------------------------------- 180
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 270 khpfrnllqrrnrpqLVIAVALQIFQQCTGINAIMFYAPVLFSTLGfGSDASLYSAVVTGAVNVLSTLVSIYSVDKVGRR 349
Cdd:cd17315 181 ---------------LLVGVGLQLLQQLTGINAVMYYAPTIFKSAG-GGTASILASIIVGVVNLLATLVAIRLVDKVGRR 244
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 350 VLLLEAGVQMFFSQVVIAIILGVKVtdtstnLSKGFAILVVVMICTYVAAFAWSWGPLGWLIPSETFPLETRSAGQSVTV 429
Cdd:cd17315 245 PLLLIGFAGMAASLLLLAIAFLLPA------LAKAAGWLALLGILLYIAAFAMGAGPVPWLLLSEIFPLRIRGKGMAIAT 318
                       410       420       430       440
                ....*....|....*....|....*....|....*....|....*..
gi 15240313 430 CVNLLFTFIIAQAFLSMLCHF-KFGIFIFFSAWVLIMSVFVMFLLPE 475
Cdd:cd17315 319 LVNWIFNFIVGLTFLIMVSTIgLAGVFIFFAAVCLLALVFVFFFVPE 365
MFS_HXT cd17356
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ...
27-484 1.19e-85

Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340914 [Multi-domain]  Cd Length: 403  Bit Score: 270.28  E-value: 1.19e-85
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313  27 CIMAATGGLMFGYDVGVSGGVTSMPDFLEKFfpvvyrkvvagaDKDSNYCKYDNQGLQLFTSSLYLAGLTATFFASYTTR 106
Cdd:cd17356   3 CAFVSLGGFLFGYDTGSISGILNMKSFQKYF------------ADNTGTYYPSSSRQGLIVSIVNLGSFFGALISSFLSD 70
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 107 TLGRRLTMLIAGVFFIIGVALNAGAQD-LAMLIAGRILLGCGVGFANQAVPLFLSEIAPTRIRGGLNILFQLNVTIGILF 185
Cdd:cd17356  71 RIGRKKSIQIGCVIYIIGAIIQVAAIGkWYQLIVGRIIAGLGVGFASVLVPVYQSEVAPKHIRGTLVSLYQLAITIGILV 150
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 186 ANLVNYGTAKIKGGWGWRLSLGLAGIPALLLTVGALLVTETPNslvergrldegkavlrrirgtdnvepefadlleasrl 265
Cdd:cd17356 151 AYCINYGTHKLDGSAQWRIPLGLQIVWGLLLLIGMFFLPESPR------------------------------------- 193
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 266 akevkhpfrnLLQRrnrpqLVIAVALQIFQQCTGINAIMFYAPVLFSTLGFGSDASLYSAVVTGAVNVLSTLVSIYSVDK 345
Cdd:cd17356 194 ----------WLYR-----TILGIMLQLFQQLTGINYFFYYGTTIFQSTGLTGSSPLLTSIILYIVNFVSTIPGLFFVDK 258
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 346 VGRRVLLLEAGVQMFFSQVVIAIILGVKVTDTSTNL--SKGFAILVVVMICTYVAAFAWSWGPLGWLIPSETFPLETRSA 423
Cdd:cd17356 259 FGRRTCLLIGAAGMSICLFIYAAVGVRYLIPNPQSGtsNKSAGNGMIVFICLFIFSFATTWGPIAWVYVAEVFPLRVRSK 338
                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15240313 424 GQSVTVCVNLLFTFIIAQAFLSMLCHFKFGIFIFFSAWVLIMSVFVMFLLPETKNIPIEEM 484
Cdd:cd17356 339 GMALATAFNWLWNFLISFFTPFIIGSIGFKYYYIFAGCNLLAFIVVFFFVPETKGLTLEEI 399
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
85-483 2.66e-78

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 252.11  E-value: 2.66e-78
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313  85 LFTSSLYLAGLTATFFASYTTRTLGRRLTMLIAGVFFIIGVALNAGAQDLAMLIAGRILLGCGVGFANQAVPLFLSEIAP 164
Cdd:cd17358  45 WFGSLLTLGALIGALLSGKLADRIGRKRTLLISAIPCILGWLLIAFAKDVWMLYLGRFLAGFGGGAASVVVPVYIAEIAP 124
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 165 TRIRGGLNILFQLNVTIGILFANLVNYGTAkikggwgWRLSLGLAGIPALLLTVGALLVTETPNSLVERGRLDEGKAVLR 244
Cdd:cd17358 125 KNVRGALGSLNQLLVNIGILLGYVLGSFLP-------WRTLALIGAIPPVVFLILLFFIPESPRWLAKKGREEEAEKSLQ 197
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 245 RIRGTD-NVEPEFADLLEA----SRLAKEVKhpFRNLLQRRNRPQLVIAVALQIFQQCTGINAIMFYAPVLFSTLGFGSD 319
Cdd:cd17358 198 FLRGKDaDISKEAAEIQEElaelEKEAKESS--FSDLFQRKYLKPLVIGLGLMLFQQLSGINAVIFYASSIFDEAGSGLD 275
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 320 ASLySAVVTGAVNVLSTLVSIYSVDKVGRRVLLLEAGVQMFFSQVVIAIILGVKvtdTSTNLSKGFAILVVVMICTYVAA 399
Cdd:cd17358 276 PNT-ATIIIGVVQVVGTLVATLLVDRLGRRPLLLVSAIGMGIGLLALGLYFYLQ---EHGALLSSVSWLPLVGLVIYIIS 351
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 400 FAWSWGPLGWLIPSETFPLETRSAGQSVTVCVNLLFTFIIAQAFLSMLCHFK-FGIFIFFSAWVLIMSVFVMFLLPETKN 478
Cdd:cd17358 352 FSIGLGPLPWVIMSEIFPAKIKGLAGSLVTLVNWLFAFIVTKTFPFLTLAWGaSGTFWIFAGICGLALVFVLLFVPETKG 431

                ....*
gi 15240313 479 IPIEE 483
Cdd:cd17358 432 KSLEE 436
MFS_XylE_like cd17359
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...
27-475 9.68e-74

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340917 [Multi-domain]  Cd Length: 383  Bit Score: 238.62  E-value: 9.68e-74
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313  27 CIMAATGGLMFGYDVGVSGGVTsmpDFLEKFFPVvyrkvvagadkdsnyckyDNQGLQLFTSSLYLAGLTATFFASYTTR 106
Cdd:cd17359   3 SLVAALGGLLFGYDTGVINGAL---PFLQTDFNL------------------TPFLEGLVVSSALLGAAIGALFAGRLAD 61
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 107 TLGRRLTMLIAGVFFIIGVALNAGAQDLAMLIAGRILLGCGVGFANQAVPLFLSEIAPTRIRGGLNILFQLNVTIGILFA 186
Cdd:cd17359  62 RFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARIIGGLAVGGASALVPMYIAEVAPAEIRGRLVSLNQLMIVFGQLLA 141
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 187 NLVNYGTAKIKGGW-----GWRLSLGLAGIPALLLTVGALLVTETPNSLVERGRldegkavlrrirgtdnvepefadlle 261
Cdd:cd17359 142 YIVNYLIANAGGADwlgaeGWRWMLGLEAIPAILFLLGMLFIPESPRWLVSKGK-------------------------- 195
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 262 asrlakevkhpfrnllqrrnrPQLVIAVALQIFQQCTGINAIMFYAPVLFSTLGFGSDASLYSAVVTGAVNVLSTLVSIY 341
Cdd:cd17359 196 ---------------------PILIIGIGLAIFQQFVGINVIFYYGPEIFQNAGFSENAALLQTIGIGVVNVIFTIIAIL 254
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 342 SVDKVGRRVLLLEAGVQMFFSQVVIAIILgvkvtdTSTNLSKGFAILVVVMICTYVAAFAWSWGPLGWLIPSETFPLETR 421
Cdd:cd17359 255 LVDKVGRKPLLLIGSIGMAISLLLIGTAF------YFAPGSQASGIVALVLILLFVAFFAMSWGPVTWVLLSEIFPNRIR 328
                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|....*
gi 15240313 422 SAGQSVTVCVNLLFTFIIAQAFLSMLCHFKFG-IFIFFSAWVLIMSVFVMFLLPE 475
Cdd:cd17359 329 GLAMGIAVFFLWIANFLVSLTFPILLAAFGLAfTFLIFAVICVLAFLFVWKFVPE 383
MFS_HMIT_like cd17360
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ...
30-475 3.19e-67

H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340918 [Multi-domain]  Cd Length: 362  Bit Score: 220.99  E-value: 3.19e-67
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313  30 AATGGLMFGYDVGV-SGGVTSMPDFLEKFfpvvyrkvvagadkdsnycKYDNQGLQLFTSSLYLAGLTATFFASYTTRTL 108
Cdd:cd17360   2 AGIGGFLFGYDTGViSGALLYIKDDLGEV-------------------VLSTGWQELIVSSTVAGAAVGAAIGGWLNDRF 62
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 109 GRRLTMLIAGVFFIIGVALNAGAQDLAMLIAGRILLGCGVGFANQAVPLFLSEIAPTRIRGGLNILFQLNVTIGILFANL 188
Cdd:cd17360  63 GRRPCILLADALFTIGAIVMAAAPNKEVLIVGRVLVGLGVGIASMTVPLYIAEAAPPRIRGRLVTINVLFITGGQFVAYV 142
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 189 VNYGTAKIKGGWgwRLSLGLAGIPALLLTVGALLVTETPnslvergrldegkavlRRirgtdnvepefadlleasrlake 268
Cdd:cd17360 143 INGAFSYLPGGW--RWMLGLAAVPAVLQFIGLLFLPESP----------------RW----------------------- 181
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 269 vkhpfrnllqRRNRPQLVIAVALQIFQQCTGINAIMFYAPVLFSTLGFGSDA-SLYSAVVTGAVNVLSTLVSIYSVDKVG 347
Cdd:cd17360 182 ----------PSTRRALIVGCGLQAFQQFSGINTVMYYSATILQMAGFKDNQnAIWLSLIVAGTNFIFTIVGMYLIDKFG 251
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 348 RRVLLLEAGVQMFFSQVVIAIILgvkvtdtstnlskgfailVVVMICTYVAAFAWSWGPLGWLIPSETFPLETRSAGQSV 427
Cdd:cd17360 252 RRKLLLISLFGVIVALVVLAVWL------------------ALVGLILYLAFFAPGMGPVPWTVNSEIYPLWARGTGGGC 313
                       410       420       430       440
                ....*....|....*....|....*....|....*....|....*....
gi 15240313 428 TVCVNLLFTFIIAQAFLSMLCHF-KFGIFIFFSAWVLIMSVFVMFLLPE 475
Cdd:cd17360 314 AAAVNWVFNLLVSQTFLTLTQAIgPYGTFLLFAGLAVLGLIFIYFCVPE 362
xylE PRK10077
D-xylose transporter XylE; Provisional
24-491 1.04e-61

D-xylose transporter XylE; Provisional


Pssm-ID: 182225 [Multi-domain]  Cd Length: 479  Bit Score: 209.93  E-value: 1.04e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313   24 IISCIMAAT-GGLMFGYDVGV-SGGVTSmpdfLEKFFpvvyrkvVAGADKDSNYCKydnqGLQLFTSSLYLAG-LTATFF 100
Cdd:PRK10077  10 IFSITLVATlGGLLFGYDTAViSGTVES----LNTVF-------VAPQNLSESAAN----SLLGFCVASALIGcIIGGAL 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313  101 ASYTTRTLGRRLTMLIAGVFFIIGvALNA----------GAQDLAMLIA---GRILLGCGVGFANQAVPLFLSEIAPTRI 167
Cdd:PRK10077  75 GGYCSNRFGRRDSLKIAAVLFFIS-ALGSawpefgftsiGPDNTGYVPEfviYRIIGGIGVGLASMLSPMYIAEIAPAHI 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313  168 RGGLNILFQLNVTIGILFANLVNYGTAKIKGG-W----GWRLSLGLAGIPALLLTVGALLVTETPNSLVERGRLDEGKAV 242
Cdd:PRK10077 154 RGKLVSFNQFAIIFGQLVVYFVNYFIARSGDAsWlntdGWRYMFASEAIPALLFLMLLYFVPETPRYLMSRGKQEQAEGI 233
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313  243 LRRIRGTDNVEPEFADLLEASRLAKEVKHPfrnlLQRRNRPQLVIAVALQIFQQCTGINAIMFYAPVLFSTLGFGSDASL 322
Cdd:PRK10077 234 LRKIMGNTLATQALQEIKHSLDHGRKTGGK----LLMFGVGVIVIGVMLSVFQQFVGINVVLYYAPEIFKTLGASTDIAL 309
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313  323 YSAVVTGAVNVLSTLVSIYSVDKVGRRVLLLEAGVQMFFSQVVIAIILgvkvtdtSTNLSkgfAILVVVMICTYVAAFAW 402
Cdd:PRK10077 310 LQTIIVGVINLTFTVLAIMTVDKFGRKPLQIIGALGMAIGMFSLGTAF-------YTQAP---GIVALLSMLFYVAAFAM 379
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313  403 SWGPLGWLIPSETFPLETRSAGQSVTVCVNLLFTFIIAQAFLSM------LCHFKFGififFSAWVL-IMSV----FVMF 471
Cdd:PRK10077 380 SWGPVCWVLLSEIFPNAIRGKALAIAVAAQWIANYFVSWTFPMMdknswlVAHFHNG----FSYWIYgCMGVlaalFMWK 455
                        490       500
                 ....*....|....*....|
gi 15240313  472 LLPETKNIPIEEMtERVWKK 491
Cdd:PRK10077 456 FVPETKGKTLEEM-EALWEP 474
MFS_GLUT_Class1 cd17431
Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ...
30-478 4.16e-61

Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-4 are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT1, also called solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1), displays broad substrate specificity and can transport a wide range of pentoses and hexoses including glucose, galactose, mannose, and glucosamine. It is found in the brain, erythrocytes, and in many fetal tissues. GLUT2 (or SLC2A2) is found in the liver, islet of Langerhans, intestine, and kidney, and is the isoform that likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by beta cells. GLUT3 (or SLC2A3) is found in the brain and can mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and dehydroascorbate. GLUT4 (or SLC2A4) is an insulin-regulated facilitative glucose transporter found in adipose tissues, and in skeletal and cardiac muscle. GLUT14 (or SLC2A14) is an orphan transporter expressed mainly in the testis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340989 [Multi-domain]  Cd Length: 445  Bit Score: 207.57  E-value: 4.16e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313  30 AATGGLMFGYDVGV---SGGVtsMPDFLEKFFPVVYRKVVAGADKDSNYckydnqglQLFTSSLYLAGLTATFFASYTTR 106
Cdd:cd17431   6 AVLGSLQFGYNTGVinaPQKV--IEEFYNKTLGDRYGEPISPETLTTLW--------SLSVAIFSVGGMIGSFSVGLFVN 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 107 TLGRRLTMLIAGVFFIIGVALnAGAQDLA----MLIAGRILLGCGVGFANQAVPLFLSEIAPTRIRGGLNILFQLNVTIG 182
Cdd:cd17431  76 RFGRRNSMLYNNLLAFAGAAL-MGLSKLAksyeMLILGRFIIGLYCGLTTGLVPMYIGEISPTALRGALGTLHQLGIVVG 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 183 ILFANLvnYGTAKIKG-GWGWRLSLGLAGIPALLLTVGALLVTETPNSL-VERGRLDEGKAVLRRIRGTDNVEPEFADLL 260
Cdd:cd17431 155 ILISQI--FGLEFILGtEELWPLLLGFTIVPAILQLALLPFCPESPRYLlINRNEEEEAKSVLKKLRGTTDVSEDIQEMK 232
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 261 EASRLAKEVKHP-----FRNllqRRNRPQLVIAVALQIFQQCTGINAIMFYAPVLFSTLGFGSdaSLYSAVVTGAVNVLS 335
Cdd:cd17431 233 EESRQMMREKKVtilelFRS---SSYRQPIIIAIVLQLSQQLSGINAVFYYSTSIFEKAGVQQ--PVYATIGAGVVNTIF 307
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 336 TLVSIYSVDKVGRRVLLLEAGVQMFFSQVVIAIILGVKVTDtstnlsKGFAILVVVMICTYVAAFAWSWGPLGWLIPSET 415
Cdd:cd17431 308 TVVSLFLVERAGRRTLHLIGLGGMAICAILMTIALLLLEGY------PWMSYVSIVAIFGFVAFFEIGPGPIPWFIVAEL 381
                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15240313 416 FPLETRSAGQSVTVCVNLLFTFIIAQAFLSM--LCHFKfgIFIFFSAWVLIMSVFVMFLLPETKN 478
Cdd:cd17431 382 FSQGPRPAAMAVAGFSNWTSNFIVGMCFQYIanLCGPY--VFIIFTVFLLTFFIFTYFKVPETKG 444
MFS_GLUT10_12_Class3_like cd17362
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ...
30-484 6.71e-61

Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340920 [Multi-domain]  Cd Length: 389  Bit Score: 205.28  E-value: 6.71e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313  30 AATGGLMFGYDVGVSGGVTSmpdflekffpvvyrKVVAGADKDSNYCKYDNQGLQLFTSSLYLAGLTATFFASYTTRTLG 109
Cdd:cd17362   2 PALGGLLFGYDIGATSGALL--------------SITSPALSGTDWYNLSSLQSGLVVSGSLLGALLGSLVAGALIDRLG 67
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 110 RRLTMLIAGVFFIIGVALNAGAQDLAMLIAGRILLGCGVGFANQAVPLFLSEIAPTRIRGGLNILFQLNVTIGILFANLV 189
Cdd:cd17362  68 RRKELILAALLYLVGSLVTGLAPSYPVLLVGRLIYGVGIGLAMHAAPVYIAETSPSHIRGLLVSLKELFIVLGILLGYVS 147
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 190 NYGTAKIKggWGWRLSLGLAGIPALLLTVGALLVTETPNslvergrldegkavlrrirgtdnvepefadlleasrlakev 269
Cdd:cd17362 148 GYAFADVV--GGWRYMYGLAAPPALLLGIGMWFLPPSPR----------------------------------------- 184
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 270 khpfrnlLQRRNRPQLVIAVALQIFQQCTGINAIMFYAPVLFSTLGF--GSDASLYSaVVTGAVNVLSTLVSIYSVDKVG 347
Cdd:cd17362 185 -------WQGNYRKPLIIGLGLVLFQQITGQPSVLYYAATIFKSAGFsaASDATLVS-VGLGVFKLLMTIVAVLLVDKLG 256
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 348 RRVLLLEAGVQMFFSQVVIAIILGVKVTDTStnlskGFAILVVVMICTYVAAFAWSWGPLGWLIPSETFPLETRSAGQSV 427
Cdd:cd17362 257 RRPLLLGGVSGMVVSLFLLAAYNLFVQMGPA-----GLAWLSLVALLLYVGAYQISFGPISWLMVSEIFPLRVRGRAIAL 331
                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15240313 428 TVCVNLLFTFIIAQAFLSM-------LCHFKFGIFIFFSAWvlimsvFVMFLLPETKNIPIEEM 484
Cdd:cd17362 332 AVLVNFGSNALVSLAFLPLqeliglpGTFLGFGVIGVLALL------FIYFTVPETKGLSLEEI 389
MFS_PLT cd17437
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The ...
29-484 7.59e-61

Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The plant Polyol transporter (PLT) subfamily includes PLT1-6 from Arabidopsis thaliana and similar transporters. The best characterized member of the group is Polyol transporter 5, also called Sugar-proton symporter PLT5, which mediates the H+-symport of numerous substrates including linear polyols (such as sorbitol, xylitol, erythritol or glycerol), cyclic polyol myo-inositol, and different hexoses, pentoses (including ribose), tetroses, and sugar alcohols. It functions to transport a wide range of substrates into specific sink tissues in the plant. The PLT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340995 [Multi-domain]  Cd Length: 387  Bit Score: 204.94  E-value: 7.59e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313  29 MAATGGLMFGYDVGV-SGGVTSMPDFLekffpvvyrkvvagadkdsnycKYDNQGLQLFTSSLYLAGLTATFFASYTTRT 107
Cdd:cd17437   1 LASLNSILLGYDIGVmSGAVIFIKEDL----------------------KISDVQEEVLIGSLNIISLVGSLAAGRTSDW 58
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 108 LGRRLTMLIAGVFFIIGVALNAGAQDLAMLIAGRILLGCGVGFANQAVPLFLSEIAPTRIRGGLNILFQLNVTIGILFAN 187
Cdd:cd17437  59 IGRRYTIALAALIFFVGALLMGVAPNYPVLMVGRFVAGIGVGFALMIAPVYTAEVAPASSRGFLTSFPEIFINIGILLGY 138
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 188 LVNYGTAKIKGGWGWRLSLGLAGIPALLLTVGALLVTETPnslvergrldegkavlrriRGTDNVepefadlleasrlak 267
Cdd:cd17437 139 VSNYAFSGLPLHVGWRLMLGVGAVPSLFLAIGVLAMPESP-------------------RWTPAV--------------- 184
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 268 evkhpfrnllqrrnRPQLVIAVALQIFQQCTGINAIMFYAPVLFSTLGFGSDASLYSAVV-TGAVNVLSTLVSIYSVDKV 346
Cdd:cd17437 185 --------------RRMLIAALGIHFFQQASGIDAVVLYSPRIFKKAGIKSKDKLLLATVaVGVTKTLFILVATFLLDKV 250
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 347 GRRVLLLEAGVQMFFSQVVIAIilGVKVTDTSTNLSKGFAILVVVMICTYVAAFAWSWGPLGWLIPSETFPLETRSAGQS 426
Cdd:cd17437 251 GRRPLLLTSTGGMTLSLTALAT--SLTFIDRNGGGLTWALVLAITAVCSFVAFFSIGAGPITWVYSSEIFPLRLRAQGAS 328
                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 15240313 427 VTVCVNLLFTFIIAQAFLSMLCHFKF-GIFIFFSAWVLIMSVFVMFLLPETKNIPIEEM 484
Cdd:cd17437 329 LGVVVNRLMSGTVSMTFLSMSKAITTgGTFFLFAGVAAAAWVFFYFFLPETKGKSLEEI 387
MFS_GLUT_Class1_2_like cd17357
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ...
85-478 2.97e-59

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340915 [Multi-domain]  Cd Length: 447  Bit Score: 202.49  E-value: 2.97e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313  85 LFTSSLYLAGLTATFFASYTTRTLGRRLTMLIAGVFFIIGvALNAGAQDLA----MLIAGRILLGCGVGFANQAVPLFLS 160
Cdd:cd17357  53 LIVSIFFIGGAIGSFISAFLANRFGRKNGLLISNALLVVS-SLLMFLSKSAkspeLLIFGRFLVGIACGLSTGFVPMYLQ 131
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 161 EIAPTRIRGGLNILFQLNVTIGILFANLvnYGTAKIKGGW-GWRLSLGLAGIPALLLTVGALLVTETPNSLV-ERGRLDE 238
Cdd:cd17357 132 EISPSELRGALGSLTQIGVTLGILLGQV--FGLPSVLGTEtLWPYLLFFPGIPALLQLAALPFFPESPKFLLiSKGDEEE 209
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 239 GKAVLRRIRG-TDNVEPEFADLL-----EASRLAKEVKHPFRNllqRRNRPQLVIAVALQIFQQCTGINAIMFYAPVLFS 312
Cdd:cd17357 210 AEKSLKFLRGiEDDVDQELEEIKkeseqMGDQKQVSLMQLLRD---PSLRLPLLLVLVVSASQQFSGINAIFFYSTFIFE 286
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 313 TLGFGSDASLYSAVVTGAVNVLSTLVSIYSVDKVGRRVLLLEAgvqmFFSQVVIAIILGVKVTDTSTNLSKGFaiLVVVM 392
Cdd:cd17357 287 NAGFSPQLAEWANLGIGIVNVLSTIVGPFLIEKVGRRPLLLIS----LSVCAVALLLMSVFLFLSEQNSWMSY--GCIVA 360
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 393 ICTYVAAFAWSWGPLGWLIPSETFPLETRSAGQSVTVCVNLLFTFIIAQAFLSMLCHFKFGIFIFFSAWVLIMSVFVMFL 472
Cdd:cd17357 361 IFLFIFFFAIGLGPIPWFIGAELFPQAPRSAAQSLGSSVNWTSNFIVGMAFPPLQSIGGGFVFIIFAIPCALFLLYLYRY 440

                ....*.
gi 15240313 473 LPETKN 478
Cdd:cd17357 441 LPETKG 446
MFS_GLUT8_Class3 cd17433
Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of ...
25-483 3.07e-55

Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 8 (GLUT8) is also called Solute carrier family 2, facilitated glucose transporter member 8 (SLC2A8) or glucose transporter type X1 (GLUTX1). It is classified as a Class 3 GLUT protein and is an insulin-regulated facilitative glucose transporter predominantly expressed in testis and brain. It can also transport fructose and galactose. SLC2A8 knockout mice were viable, developed normally, and display only a very mild phenotype, including mild alterations in the brain (increased proliferation of hippocampal neurons), heart (impaired transmission of electrical wave through the atrium), and sperm cells (reduced number of motile sperm cells). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340991 [Multi-domain]  Cd Length: 416  Bit Score: 191.24  E-value: 3.07e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313  25 ISCIMAATGGLMFGYDVGVSGgvTSMPDfLEKFFPVVYRkvvagadkdsnyckYDNQGLQLFTSSLYLAGLTATFFASYT 104
Cdd:cd17433   2 LATFAAVLGPLSFGFVLGYSS--PAIPS-LQRIADPALR--------------LDDAAASWFGSVVTLGAAAGGVLGGWI 64
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 105 TRTLGRRLTMLIAGVFFIIGVALNAGAQDLAMLIAGRILLGCGVGFANQAVPLFLSEIAPTRIRGGLNILFQLNVTIGIL 184
Cdd:cd17433  65 VDRAGRKLSLMLCSVPFIAGFTVITAAQNVWMLYVGRLLTGLASGVTSLVVPVYISEIAHPRVRGTLGSCVQLMVVIGIM 144
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 185 FANLVnygtakikgGW--GWRLSLGLAGIPALLLTVGALLVTETPNSLVERGRLDEGKAVLRRIRGTDNVEPEFADLLEA 262
Cdd:cd17433 145 GAYLA---------GLvlDWRWLAVLGSIPPTLMLLLMCFMPETPRFLLTQHRRQEAMAALRFLRGPDQGWEWECIGIEQ 215
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 263 SRLAKEVKHPFRNLLQRRNRPQLVIAVALQIFQQCTGINAIMFYAPVLFSTLGFGSdaSLYSAVVTGAVNVLSTLVSIYS 342
Cdd:cd17433 216 SFHLEEQSFSLALLKQPGIYKPLIIGVSLMAFQQLTGINAVMFYAETIFEEAKFKD--SSVASVIVAAIQVLFTAVAALI 293
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 343 VDKVGRRVLLLEAGVQMFFSQVViaiilgvkvtdtstnlskgFAILVVVMICTYVAAFAWSWGPLGWLIPSETFPLETRS 422
Cdd:cd17433 294 MDRAGRKVLLVLSGVVMVFSTAA-------------------FGWLAVGSMGFFIAGFAVGWGPIPWLVMSEIFPLHVRG 354
                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15240313 423 AGQSVTVCVNLLFTFIIAQAFLSMLCHFK-FGIFIFFSAWVLIMSVFVMFLLPETKNIPIEE 483
Cdd:cd17433 355 VASGICVLTNWLMAFLVTKEFSSLMEVLSsYGTFWLFSAFCAFSVLFTLFCVPETKGKTLEQ 416
MFS_GLUT_Class2 cd17432
Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ...
86-478 9.98e-50

Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT5, also called Solute carrier family 2, facilitated glucose transporter member 5 (SLC2A5), is a well-established fructose transporter found in the small intestine. GLUT7 (or SLC2A7) is a high-affinity glucose and fructose transporter expressed in the small intestine and colon. GLUT9 (or SLC2A9) transports urate and fructose, and is most strongly expressed in the basolateral membranes of proximal renal tubular cells, liver and placenta. It may play a role in urate reabsorption by proximal tubules. GLUT11 (or SLC2A11) is a facilitative glucose transporter expressed in heart and skeletal muscle. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340990 [Multi-domain]  Cd Length: 452  Bit Score: 177.04  E-value: 9.98e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313  86 FTSSLY-LAGLTATFFASYTTRTLGRRLTMLIAGVFFIIGvALNAGAQDLA----MLIAGRILLGCGVGFANQAVPLFLS 160
Cdd:cd17432  54 LTVSIFpLGGLFGSLLVGPLVIRLGRKGTLLLNNIFAIVA-AILMGLSKIAksfeMIIVGRFLVGINAGISLNVVPMYLG 132
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 161 EIAPTRIRGGLNILFQLNVTIGILFANLVnyGTAKIKGG-WGWRLSLGLAGIPALLLTVGALLVTETPN-SLVERGRLDE 238
Cdd:cd17432 133 ESAPKNLRGAVGLVPAIFITLGILLGQVL--GLRELLGNeEGWPLLLALTGVPALLQLLTLPFFPESPRyLLIEKGDEEA 210
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 239 GKAVLRRIRGTDNVEPEFADLLEASRLAKEVKH-PFRNLLQRRN-RPQLVIAVALQIFQQCTGINAIMFYAPVLFSTLGF 316
Cdd:cd17432 211 ARKALQRLRGKEDVDDEMEEMLEEQRAEKGVGTvSVLELFRDRSvRWQLISIIVLMAGQQLCGINAIYFYADSIFLEAGI 290
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 317 GSDASLYSAVVTGAVNVLSTLVSIYSVDKVGRRVLLLEAGVQMFFSQVVIAIILGVKvtDTSTNLSkgfaILVVVMICTY 396
Cdd:cd17432 291 PEDKIQYVTVGTGACEVLATITCVLVIERLGRRPLLIGGFGLMAVWCAVLTVALSLQ--NTVSWMP----YLSIVCIFAY 364
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 397 VAAFAWSWGPLGWLIPSETFPLETRSAGQSVTVCVNLLFTFIIAQAFLSMLCHFKFGIFIFFSAWVLIMSVFVMFLLPET 476
Cdd:cd17432 365 IASFGIGPAGVPFILTTEIFDQSSRPAAFMVAGSLNWLSNFLVGLLFPFIQEGLGAYCFLVFAVICLLTAIYIFFVLPET 444

                ..
gi 15240313 477 KN 478
Cdd:cd17432 445 KG 446
MFS_GLUT6_Class3 cd17434
Glucose transporter type 6, a Class 3 GLUT, of the Major Facilitator Superfamily of ...
77-483 2.08e-37

Glucose transporter type 6, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 6 (GLUT6) is also called Solute carrier family 2, facilitated glucose transporter member 6 (SLC2A6). It is classified as a Class 3 GLUT protein, and is a facilitative glucose transporter that binds cytochalasin B with low affinity. It is found in the brain, spleen, and leucocytes. GLUT6 may function in oxalate secretion. SLC2A6 has been identified as an oxalate nephrolithiasis gene in mice; its deletion causes spontaneous calcium oxalate nephrolithiasis in the setting of hyperoxalaemia, hyperoxaluria, and nephrocalcinosis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340992 [Multi-domain]  Cd Length: 417  Bit Score: 142.66  E-value: 2.08e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313  77 KYDNQGLQL-------FTSSLYLAGLTATFFASYTTRTLGRRLTMLIAGVFFIIGVALNAGAQDLAMLIAGRILLGCGVG 149
Cdd:cd17434  30 QGDDPRLHLnvhqiswFGSVFTLGAAAGGLSAMFLNDRLGRKLSIMFSAVPSALGYLLMGSAQGIWMLLLGRFLTGFAGG 109
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 150 FANQAVPLFLSEIAPTRIRGGLNILFQlnvtIGILFANLVNYGTAKIKgGWGWrlsLGLAG-IPALLLTVGALLVTETPN 228
Cdd:cd17434 110 ITAASIPVYVSEISHPGVRGALGACPQ----IMAVFGSLALYALGLLL-PWRW---LAVAGeVPVVIMILLLCFMPNSPR 181
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 229 SLVERGRLDEGKAVLRRIRGTD-NVEPEFaDLLEASRLAKEVKHPFRNLLQRRNRPQLVIAVALQIFQQCTGINAIMFYA 307
Cdd:cd17434 182 FLISKGKDEKALKALAWLRGPNtDYMTEF-EQIKDNIRKQSSRLSWAELKTPSYYKPILIAVVMRFLQQLTGITPILVYL 260
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 308 PVLFSTLGFGSDASlYSAVVTGAVNVLSTLVSIYSVDKVGRRVLLLEAGVQMFFSqvviaiilgvkvtdtstNLSKGFAI 387
Cdd:cd17434 261 EPIFHLTAVILEPK-YDAALVGAVRLLSVAIAASLMDKAGRKILLFTSAFLMFAA-----------------NLSMGLIP 322
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 388 LVVVMIctYVAAFAWSWGPLGWLIPSETFPLETRSAGQSVTVCVNLLFTFIIAQAFLSMLCHFKFGI-FIFFSAWVLIMS 466
Cdd:cd17434 323 LIAAML--FIMGYAMGWGPITWLLMSEILPLKARGVASGLCVVVSWITAFVLTQLFLPVVVTFGLQVpFLFFAAVCAVSI 400
                       410
                ....*....|....*..
gi 15240313 467 VFVMFLLPETKNIPIEE 483
Cdd:cd17434 401 IFTACCVPETKGRTLEQ 417
MFS_GLUT12_Class3 cd17435
Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of ...
25-484 9.39e-37

Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 12 (GLUT12) is also called Solute carrier family 2, facilitated glucose transporter member 12 (SLC2A12). It is a facilitative glucose transporter, classified as a Class 3 GLUT, and is expressed in the heart, skeletal muscle, prostate, and small intestine, and is highly upregulated in breast ductal cell carcinoma. It plays a role as a secondary insulin-sensitive glucose transporter in insulin-dependent tissues. The GLUT12 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340993 [Multi-domain]  Cd Length: 376  Bit Score: 139.93  E-value: 9.39e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313  25 ISCIMAATGGLMFGYDVG-VSGGVTSMPDFLEkffpvvyrkvvagadkdsnyckYDNQGLQLFTSSLYLAGLTATFFASY 103
Cdd:cd17435   1 LSSVTAAVSGLLVGYELGiISGALLQLRTLLA----------------------LSCHEQEMVVSSLLIGALLASLTGGV 58
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 104 TTRTLGRRLTMLIAGVFFIIGVALNAGAQDLAMLIAGRILLGCGVGFANQAVPLFLSEIAPTRIRGGLNILFQLNVTIGI 183
Cdd:cd17435  59 LIDRYGRRTAIILTSCLLVLGSLLLVCSVSYTVLIVGRIAIGVSISLSSIATCVYIAEIAPQHRRGLLVSLNELMIVIGI 138
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 184 LFANLVNYGTAKIKGGWgwRLSLGLAGIPALLLTVGALLVTETPNSLVERgrldegkavlrrirgtDNVepefadlleas 263
Cdd:cd17435 139 LLAYISNYAFANVSNGW--KYMFGLVIPLAALQAIAMYFLPPSPRFLVMK----------------DNM----------- 189
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 264 rlakevkhpfrnllqrrnRPQLVIAVALQIFQQCTGINAIMFYAPVLFSTLGFGSD--ASLYSAVVtGAVNVLSTLVSIY 341
Cdd:cd17435 190 ------------------RARLLIGLTLVFFVQITGQPNILFYASTVLKSVGFQSNeaASLASTGV-GVVKVVSTIPAIF 250
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 342 SVDKVGRRVLLLEAGVQMFFSQVVIAIILGVkvtdtstnlskgfAILVVvmictYVAAFAWSWGPLGWLIPSETFPLETR 421
Cdd:cd17435 251 LVDKVGSKTFLCIGSSVMAVSLVTMGLWLSL-------------ASLLV-----YVAAFSIGLGPMPWLVLSEIFPGGIR 312
                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15240313 422 SAGQSVTVCVNLLFTFIIAQAFLSMLCHFKFGIFIF-FSAWVLIMSVFVMFLLPETKNIPIEEM 484
Cdd:cd17435 313 GRAMALTSSMNWGINLLISLTFLTVTELIGLPWVCFiYTAMSLASLVFVIMFVPETKGCSLEQI 376
MFS_GLUT10_Class3 cd17436
Glucose transporter type 10 (GLUT10), a Class 3 GLUT, of the Major Facilitator Superfamily of ...
88-484 3.47e-29

Glucose transporter type 10 (GLUT10), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 10 (GLUT10) is also called Solute carrier family 2, facilitated glucose transporter member 10 (SLC2A10). It is classified as a Class 3 GLUT and is a facilitative glucose transporter that exhibits a wide tissue distribution. It is expressed in pancreas, placenta, heart, lung, liver, brain, fat, muscle, and kidney. GLUT10 facilitates the transport of dehydroascorbic acid (DHA), the oxidized form of vitamin C, into mitochondria, and also increases cellular uptake of DHA, which in turn protects cells against oxidative stress. Loss-of-function mutations in SLC2A10 cause arterial tortuosity syndrome (ATS), an autosomal recessive connective tissue disorder characterized by twisting and lengthening of the major arteries, hypermobility of the joints, and laxity of skin. The GLUT10 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340994 [Multi-domain]  Cd Length: 376  Bit Score: 118.75  E-value: 3.47e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313  88 SSLYLAGLTATFFASYTTRTLGRRLTMLIAGVFFIIGVALNAGAQDLAMLIAGRILLGCGVGFANQAVPLFLSEIAPTRI 167
Cdd:cd17436  43 SALLIGALLASLIGGFLIDRHGRRTSILGSNLVLLAGSLILTLAGSFFWLVIGRAVVGFAISVSSMACCIYVSEMVTPHQ 122
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 168 RGGLNILFQLNVTIGILFANLVNYGTAKIKggWGWRLSLGLAGIPALLLTVGALLVTETPNSLVERgrldegkavlrrir 247
Cdd:cd17436 123 RGLLVSLYEAGITVGILISYALNYFFSNVL--TGWRYMFGLAIIPAAIQFASILLLPKKPEVLNIK-------------- 186
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 248 gtDNVepefadlleasrlakevkhpfrnllqrrnRPQLVIAVALQIFQQCTGINAIMFYAPVLFSTLGFGSDAS-LYSAV 326
Cdd:cd17436 187 --DNM-----------------------------RRRTLVGLGLVLFQQFTGQPNVLCYASTIFRSVGFQSNSSaVLASV 235
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 327 VTGAVNVLSTLVSIYSVDKVGRRVLLLEAGVQMFFSQVVIaiilgvkvtdtstnlskGFAILVVVMIcTYVAAFAWSWGP 406
Cdd:cd17436 236 GLGVVKVIATLLAMLFADRAGRRSLLIAGCSVMAVSVSGI-----------------GLWITLLCLM-AFVSAFSIGFGP 297
                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15240313 407 LGWLIPSETFPLETRSAGQSVTVCVNLLFTFIIAQAFLSMLCHFKFG-IFIFFSAWVLIMSVFVMFLLPETKNIPIEEM 484
Cdd:cd17436 298 MTWLVLSEIYPADIRGRAFSFCNSFNWAANLLITLSFLDLIDVIGLSwTFLLYGVVGVAGVVFIYLFVPETKGQSLEEI 376
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
83-427 1.75e-16

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 80.79  E-value: 1.75e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313  83 LQLFTSSLYLAGLTATFFASYTTRTLGRRLTMLIAGVFFIIGVALNAGAQDLAMLIAGRILLGCGVGFANQAVPLFLSEI 162
Cdd:COG2814  47 AGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADL 126
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 163 APTRIRGGLNILFQLNVTIGILFANLVNYGtakIKGGWGWRLSLGLAGIPALLLTVGALLVTetPNSLVERgrldegkav 242
Cdd:COG2814 127 VPPERRGRALGLLGAGLGLGPALGPLLGGL---LADLFGWRWVFLVNAVLALLALLLLLRLL--PESRPAA--------- 192
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 243 lrrirgtdnvepefadlleASRLAKEVKHPFRnllqrrnRPQLVIAVALQIFQQCTGINAIMFYAPVLFSTLGFGSDASL 322
Cdd:COG2814 193 -------------------RARLRGSLRELLR-------RPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAG 246
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 323 YSAVVTGAVNVLSTLVSIYSVDKVGRRVLLLEAGVQMFFSQVVIAIILGvkvtdtstnlskgfaiLVVVMICTYVAAFAW 402
Cdd:COG2814 247 LLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGS----------------LWLLLLALFLLGFGF 310
                       330       340
                ....*....|....*....|....*.
gi 15240313 403 S-WGPLGWLIPSETFPLETRSAGQSV 427
Cdd:COG2814 311 GlLFPLLQALVAELAPPEARGRASGL 336
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
85-468 9.32e-15

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 75.93  E-value: 9.32e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313  85 LFTSSLYLAGLTATFFASYTTRTLGRRLTMLIAGVFFIIGVALNAGAQDLAMLIAGRILLGCGVGFANQAVPLFLSEIAP 164
Cdd:cd06174  35 LLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFP 114
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 165 TRIRGGLNILFQLNVTIGILFANLVNYGTAKIkGGWGWRLSLGLAGIPALLLTVGALLVTETPNSLVERGrldegkavlr 244
Cdd:cd06174 115 ERERGRALGLLQAFGSVGGILGPLLGGILASS-LGFGWRAVFLIAAALALLAAILLLLVVPDPPESARAK---------- 183
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 245 rirgtdnvepefadllEASRLAKEVKHPFRNLLQRRNrpqLVIAVALQIFQQCTGINAIMFYAPVLFSTLGFGSDASLYS 324
Cdd:cd06174 184 ----------------NEEASSKSVLKLLKRVLKNPG---LWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLL 244
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 325 AVVTGAVNVLSTLVSIYSVDKVGRRVLLLEAGvqmFFSQVVIAIILGvkvtdtstnLSKGFAILVVVMICtyVAAFAWSW 404
Cdd:cd06174 245 LSLFGLAGALGSLLLGLLSDRLIGRKPLLLIG---LLLMALGLALLL---------LAPSLLLLLLLLLL--LGFGLGGL 310
                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15240313 405 GPLGWLIPSETFPLETRSAGQSVTVCVNLLFTFIIAQAFLSMLCHFK--FGIFIFFSAWVLIMSVF 468
Cdd:cd06174 311 LPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFglTGAFLVLAVLLLLAAIL 376
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
85-471 7.42e-14

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 73.02  E-value: 7.42e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313  85 LFTSSLYLAGLTATFFASYTTRTLGRRLTMLIAGVFFIIGVALNAGAQDLAMLIAGRILLGCGVGFANQAVPLFLSEIAP 164
Cdd:cd17316  40 LLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAP 119
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 165 TRIRGGLNILFQLNVTIGILFANLVNYG-TAKIKGGWGWRLSLGLAGIPALLLtvgallvtetpnslvergrldegkavl 243
Cdd:cd17316 120 SKRRGFALGLLQSGWALGALLAALVASLlIPLLSGDWGWRILFLIGALPALLA--------------------------- 172
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 244 rrirgtdnvepefadlleasrlakevkhpfrnLLQRRNrpqlVIAVALQIFQQCTGINAIMFYAPVLFST-LGFGSDASL 322
Cdd:cd17316 173 --------------------------------LLLRRR----TLLLILLWFFISFGYYGLTTFLPTYLQTvLGLSPATSS 216
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 323 YSAVVTGAVNVLSTLVSIYSVDKVGRRVLLLEAGVQMFFSQVVIAIILGVKVTdtstnlskgfaiLVVVMICTYVAAFAW 402
Cdd:cd17316 217 LYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSGSPT------------LLLLLLFILSFFVGG 284
                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15240313 403 SWGPLgWLIPSETFPLETRSAGQSVT----VCVNLLFTFIIAQAFLSMLChfkFGIFIFFSAWVLIMSVFVMF 471
Cdd:cd17316 285 VWGAL-YAYLAELFPTEVRATGVGLSynlgRLGGGGAPPLIALLLASTGG---TGVPALILALLAIVALIVAL 353
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
79-483 9.15e-14

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 73.51  E-value: 9.15e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313    79 DNQGLQLFTSSLYLAGLTATFFASYTTRTLGRR----LTMLIAGVFfiiGVaLNAGAQDLAMLIAGRILLGCGV-GFANQ 153
Cdd:TIGR00898 125 DAWKVDLTQSCFFVGVLLGSFVFGYLSDRFGRKkvllLSTLVTAVS---GV-LTAFSPNYTVFLVFRLLVGMGIgGIWVQ 200
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313   154 AVPLFLsEIAPTRIRGGLNILFQLNVTIGILFANLVNYGTAkikggwGWRLSLGLAGIPALLLTVGALLVTETPNSLVER 233
Cdd:TIGR00898 201 AVVLNT-EFLPKKQRAIVGTLIQVFFSLGLVLLPLVAYFIP------DWRWLQLAVSLPTFLFFLLSWFVPESPRWLISQ 273
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313   234 GRLDEGKAVLRRIRGTDNVEP--EFADL-LEASRLAKEVKHPFRNLLQRRNRPQLVIAVALQIFqqctgINAIMFYAPVL 310
Cdd:TIGR00898 274 GRIEEALKILQRIAKINGKKLpaEVLSLsLEKDLSSSKKQYSFLDLFRTPNLRKTTLCLMMLWF-----TTAFSYYGLVL 348
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313   311 FSTLGFGSDasLYSAVVTGAVNVLSTLVSIYSVDKVGRR----VLLLEAGVQMFFSQVVI----AIILGVKVtdtstnLS 382
Cdd:TIGR00898 349 DLGNLGGNI--YLDLFISGLVELPAKLITLLLIDRLGRRytmaASLLLAGVALLLLLFVPvdlyFLRTALAV------LG 420
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313   383 KGFAILVVVMICTYVAafawswgplgwlipsETFPLETRSAGqsVTVCVNLL-FTFIIAQAFLSMLCHFKFGIFIFFSAW 461
Cdd:TIGR00898 421 KFGITSAFQMVYLYTA---------------ELYPTVVRNLG--VGVCSTMArVGSIISPFLVYLGEKWLFLPLVLFGGL 483
                         410       420
                  ....*....|....*....|..
gi 15240313   462 VLIMSVFVMFlLPETKNIPIEE 483
Cdd:TIGR00898 484 ALLAGILTLF-LPETKGVPLPE 504
MFS_1 pfam07690
Major Facilitator Superfamily;
83-438 7.07e-13

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 69.75  E-value: 7.07e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313    83 LQLFTSSLYLAGLTATFFASYTTRTLGRRLTMLIAGVFFIIGVALNAGAQDLAMLIAGRILLGCGVGFANQAVPLFLSEI 162
Cdd:pfam07690  34 IGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADW 113
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313   163 APTRIRGGLNILFQLNVTIGILFANLVNYGTAKIkggWGWRLSLGLAGIPALLLTVGALLVTETPNSLVERGRLDEGKAV 242
Cdd:pfam07690 114 FPPEERGRALGLVSAGFGLGAALGPLLGGLLASL---FGWRAAFLILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSL 190
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313   243 LRRIRgtdnvepefadlleasrlakevkhpfrnlLQRRNRPQLVIAVALQIFqqcTGINAIMFYAPVLFSTLGFGSDASL 322
Cdd:pfam07690 191 IVAWK-----------------------------ALLRDPVLWLLLALLLFG---FAFFGLLTYLPLYQEVLGLSALLAG 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313   323 YSAVVTGAVNVLSTLVSIYSVDKVGRRVLLLEAGVQMFFSQVVIAIILGvkvtdtstnLSKGFAILVVVMICTYVAAFAW 402
Cdd:pfam07690 239 LLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSL---------TLSSLWLLLALLLLGFGFGLVF 309
                         330       340       350
                  ....*....|....*....|....*....|....*.
gi 15240313   403 swgPLGWLIPSETFPLETRSAGQSVTVCVNLLFTFI 438
Cdd:pfam07690 310 ---PALNALVSDLAPKEERGTASGLYNTAGSLGGAL 342
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
79-477 8.03e-13

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 69.90  E-value: 8.03e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313  79 DNQGLQLFTSSLYLAGLTATFFASYTTRTLGRRLTMLIAGVFFIIGVALNAGAQDLAMLIAGRILLGCGVGFANQAVPLF 158
Cdd:COG2271  43 SAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKL 122
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 159 LSEIAPTRIRGGLNILFQLNVTIGILFANLVnygTAKIKGGWGWRLSLGLAGIPALLLTVGAllvtetpnslvergrlde 238
Cdd:COG2271 123 IAEWFPPKERGRALGIFNAGGPLGGALAPPL---LGWLLAAFGWRAAFLILGLPGLLLALLR------------------ 181
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 239 gkavlrrirgtdnvepefadlleasrlakevkhpfrnllqrrnrpqlVIAVALQIFQQCTGINAIMFYAPVLF-STLGFG 317
Cdd:COG2271 182 -----------------------------------------------FWLLALAYFLVYFALYGFLTWLPTYLvEVRGLS 214
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 318 SDASLYSAVVTGAVNVLSTLVSIYSVDKVGRRVLLLeagvqMFFSQVVIAIILGVkvtdtsTNLSKGFAILVVVMICTYV 397
Cdd:COG2271 215 LAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLV-----LAIGLLLAALALLL------LALLPSPALAIALLFLAGF 283
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 398 AAFAWSwgPLGWLIPSETFPLETRSAGQSVTVCVNLLFTFIIAQAFLSMLCHFKF-GIFIFFSAWVLIMSVFVMFLLPET 476
Cdd:COG2271 284 GLGGAF--GLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYqAAFLLLAALALLAALLALLLLRET 361

                .
gi 15240313 477 K 477
Cdd:COG2271 362 R 362
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
79-248 1.19e-11

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 65.60  E-value: 1.19e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313  79 DNQGLQLFTSSLYLAGLTATFFASYTTRTLGRRLTMLIAGVFFIIGVALNAGAQDLAMLIAGRILLGCGVGFANQAVPLF 158
Cdd:COG0477  47 SSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALAL 126
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 159 LSEIAPTRIRGGLNILFQLNVTIGILFANLVNYGtakIKGGWGWRLSLGLAGIPALLLTVGALLVTETPNSLVERGRLDE 238
Cdd:COG0477 127 IAELFPARERGRALGLWGAAIGLGLALGPLLGGL---LVAALGWRWIFLINAPLGLLALVLRLRLPESRGLLLALLALAL 203
                       170
                ....*....|
gi 15240313 239 GKAVLRRIRG 248
Cdd:COG0477 204 AALLLAALAL 213
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
85-353 1.28e-11

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 66.44  E-value: 1.28e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313  85 LFTSSLYLAGLTATFFASYTTRTLGRRLTMLIAGVFFIIGVALNAGAQDLAMLIAGRILLGCGVGFANQAVPLFLSEIAP 164
Cdd:COG2807  57 LLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFP 136
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 165 TRIrGGLNILFQLNVTIGILFANLVnygTAKIKGGWGWRLSLGLAGIPALLLTVGALLvtetpnslvergrldegkaVLR 244
Cdd:COG2807 137 DRV-GLMTGLYTAAMGLGAALAAGL---TVPLAAALGWRGALAVWALLALLALLLWLP-------------------LLR 193
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 245 RIRgtdnvepefadlleASRLAKEVKHPFRNLLQRRnrpqLVIAVALQIFQQCTGINAIMFYAPVLFSTLGFGSDASLYS 324
Cdd:COG2807 194 RRP--------------AAAAAAPAAASLRSLWRSP----LAWLLTLFFGLQSLLYYAVVAWLPPILRDAGLSAATAGLL 255
                       250       260
                ....*....|....*....|....*....
gi 15240313 325 AVVTGAVNVLSTLVSIYSVDKVGRRVLLL 353
Cdd:COG2807 256 LSLFQLAGIPGSLLVPLLADRLGDRRPLL 284
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
83-476 2.40e-11

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 65.40  E-value: 2.40e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313  83 LQLFTSSLYLAGLTATF----------FASYTTRTLGRRLTMLIAGVFFIIGVALNAGAQDLAMLIAGRILLGCGVG--F 150
Cdd:cd17371  26 IAEFGLDEAEAGLLGTVtlaggaiggiLGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGLGFGgeW 105
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 151 ANQAVplFLSEIAPTRIRGGLNILFQLNVTIGILFANLVNYGTAKIKGG-WGWRLSLGLAGIPALLLTVGALLVTETPNS 229
Cdd:cd17371 106 AAGAA--LMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFPLLPPeIAWRVLFLLGALPALLVLFIRRFVKEPPQW 183
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 230 LVERGRLDEGKAvlrrirgtdnvepefadlleasrlakevkHPF-RNLLQRRNRPQLVIAVALQIFQQCTGINAIMFYAP 308
Cdd:cd17371 184 QAARAARRHFAD-----------------------------RPSlRELFSPPLLRTTLLASLLATGALGGYYGITTWLPS 234
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 309 VLFSTLGFGSDASLYSAVVTGAVNVLSTLVSIYSVDKVGRRVLLLeagvqMFFSQVVIAIILGVKVTDTSTNLskgfAIL 388
Cdd:cd17371 235 YLTGERGLSFEGSAGYLVVTILGGFLGYLAGGFLADRIGRRNNFA-----LFALGSAISILLYFFLPLSPTLI----LIL 305
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 389 VVVMICTYVAAFAwSWGPLgwliPSETFPLETRSAGQSVTVCVNLLFTFIIAQAFLSMLCHFKFGI-FIFFSAWVLIMSV 467
Cdd:cd17371 306 GFPLGFFASGPFS-GMGAY----LTELFPTAVRATAQGFCYNVGRIIGALFPFLVGFLATSGSLGTaIAVFAAVYYIAGL 380

                ....*....
gi 15240313 468 FVMFLLPET 476
Cdd:cd17371 381 VLALLLPET 389
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
83-478 3.11e-11

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 65.29  E-value: 3.11e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313  83 LQLFTSSLYLAGLTATFFASYTTRTLGRRLTMLIAGVFFIIGVALNAGAQDLAMLIAGRILLGCGVGFANQAVPLFLSEI 162
Cdd:COG2223  42 LGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKW 121
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 163 APTRIRGglnILFQLNVTIGILFANLVNYGTAKIKGGWGWRLSLGLAGIPALLLTVGALLVTETPnslvergrldegkav 242
Cdd:COG2223 122 FPPDRRG---LALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAWLFLRDP--------------- 183
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 243 lrrirgtdnvePEFADLLEASRLaKEVKHPFRNllqrrnrPQLVIAVALQIFQQCTGINAIMFYAPVLFSTLGFGSDASL 322
Cdd:COG2223 184 -----------PAGAAAAAKASL-RDQLEALRD-------PRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAG 244
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 323 YSAVVTGAVNVLSTLVSIYSVDKVGRRVLLLEAGVQMFFSQVVIAIILGvkvtdtstnlskGFAILVVVMICTYVAAFAW 402
Cdd:COG2223 245 LLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALG------------SLWLFLVLFLLLGLALGGG 312
                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15240313 403 SwGPLGWLIPsETFPLETRSAGQSVTVCVNLLFTFIIAQAFLSMLCHFKF--GIFIFFSAWVLIMSVFVMFLLPETKN 478
Cdd:COG2223 313 N-GAVFALVP-DIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSytAAFLVFAVLALVALVLTLLLYRRPRR 388
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
99-372 6.98e-11

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 63.91  E-value: 6.98e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313    99 FFASYTTRTLGRRLTMLIAGVFFIIGVALNAGAQDLAMLIAGRILLGCGVGFANQAVPLFLSEIAPTRIRGGLNILFQLN 178
Cdd:TIGR00895  70 LFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCG 149
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313   179 VTIGILFANLVnygTAKIKGGWGWRLSLGLAGI-PALLLTVGALLVTETPNSLVERgRLDEGKAVLRRIRGTDNVEPEFA 257
Cdd:TIGR00895 150 YPIGAAVGGFL---AGWLIPVFGWRSLFYVGGIaPLLLLLLLMRFLPESIDFLVSK-RPETVRRIVNAIAPQMQAEAQSA 225
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313   258 dLLEASRLAKEVKHPFRNLLQRRNRPQLVIAVALQIFQQcTGINAIMFYAPVLFSTLGFGSDASLYSAVVTGAVNVLSTL 337
Cdd:TIGR00895 226 -LPEQKSTQGTKRSVFKALFQGKTARITVLLWLLYFMLL-VGVYFLTNWLPKLMVELGFSLSLAATGGALFNFGGVIGSI 303
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 15240313   338 VSIYSVDKVGRRV---LLLEAGVQMF-----FSQVVIAIILGV 372
Cdd:TIGR00895 304 IFGWLADRLGPRVtalLLLLGAVFAVlvgstLFSPTLLLLLGA 346
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
85-216 2.49e-08

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 56.48  E-value: 2.49e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313  85 LFTSSLYLAGLTATFFASYTTRTLGRRLTMLIAGVFFIIGVALNAGAQDLAMLIAGRILLGCGVGfANQAVPLFLSEIAP 164
Cdd:cd06179  36 WISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAGTAKSVNMLIGGQALIGIGAG-TQGLGAAVASELVP 114
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 15240313 165 TRIRGGLNILFQLNVTIGILFANLVNYGTAKIKGG---WGWRLSLGLAGIPALLL 216
Cdd:cd06179 115 NKYRGLVQGVVNLVASPGSALGPLIAGALVEANAAgwrWIFYINAIFNALALILL 169
MFS_PhT cd17364
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ...
108-477 5.03e-08

Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340922 [Multi-domain]  Cd Length: 389  Bit Score: 54.98  E-value: 5.03e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 108 LGRRLTMLIAGVFFIIGVALNAGAQD------LAMLIAGRILLGCGVGFANQAVPLFLSEIAPTRIRGGLNILFQLNVTI 181
Cdd:cd17364  66 FGRKRVYGVELIIMIIGTILSALSPGstplgvMGWLIFFRFLLGIGIGGDYPLSATIMSEYANKKRRGALIAAVFAMQGF 145
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 182 GILFANLVNYGTAKIKGGW-----------GWRLSLGLAGIPALLLtvgallvtetpnslvergrldegkavlrrirgtd 250
Cdd:cd17364 146 GILAGAIVTLILSAIFEHPlpagtyhhadlVWRIVLGLGAIPALSV---------------------------------- 191
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 251 nvepefadlleasrlakevkhpfrnLLQRRnrpqLVIAVALQIFqqctgINAIMFYA-----PVLFSTLGFGSDASLYSA 325
Cdd:cd17364 192 -------------------------LYFRK----HLLGTAGTWF-----LLDIAFYGqnlfqSTIISAIGFSKTMNAYQE 237
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 326 ---------VVTGAVNVLSTLVSIYSVDKVGRRVLLLeagvQMFFSQVVIAIILGVKVTDTSTNLSKGFAIlvvVMICTY 396
Cdd:cd17364 238 lfniavgqlIIALAGTVPGYWFTVFLIDRIGRKKIQM----MGFFGMTIFLLILAGPYDHWKISTIGFFVL---YGLTFF 310
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 397 VAAFawswGPLG--WLIPSETFPLETRSAGQSVTVCVNLLFTFIIAQAFLSMLCHFKFGIFIFFSAWVLIMSVFVMFLLP 474
Cdd:cd17364 311 FSNF----GPNTttFIVPAEVFPARVRSTCHGISAASGKIGAIVGSFLFLSLTQNIGVRNVLIILAGVALLGIILTLLFP 386

                ...
gi 15240313 475 ETK 477
Cdd:cd17364 387 EEK 389
MFS_ShiA_like cd17369
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ...
135-427 5.58e-08

Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340927 [Multi-domain]  Cd Length: 408  Bit Score: 54.84  E-value: 5.58e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 135 AMLIAGRILLGCGVGFANQAVPLFLSEIAPTRIRGGLNILFQLNVTIGILFANLVNYGTAKIKG-----GWGWRlslgla 209
Cdd:cd17369 106 ILLVLLRLLQGLALGGEWGGAVLMAVEHAPPKRRGFYGSFPQLGAPVGLLLATGVFLLLSALLSdeaflSWGWR------ 179
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 210 gIP----ALLLTVGallvtetpnsLVERGRLDEgkavlrrirgtdnvEPEFADLLEAsrlAKEVKHPFRNLLqRRNRPQL 285
Cdd:cd17369 180 -IPfllsAVLVAVG----------LYIRLRLEE--------------TPVFRRAKEA---GQVVRAPLVEVL-RRHWRAL 230
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 286 VIAVALQIFQQCTGINAIMFYAPVLFSTLGFGSDASLYSAVVTGAVNVLSTLVSIYSVDKVGRRVLLLEAGVQMffsqvV 365
Cdd:cd17369 231 LLAIGLRLAENVLFYLFTTFALSYATQTLGVDRSTVLLAVLIASVVAAITIPLFGWLSDRVGRRPVYLAGALLA-----A 305
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15240313 366 IAIILGVKVTDTStnlskGFAILVVVMICTYVAAFAWSWGPLGWLIPsETFPLETRSAGQSV 427
Cdd:cd17369 306 LFAFPFFWLLDTG-----STWLIVLAAVVVLGVLHGMMYGPQAAFLA-ELFPTRVRYTGASL 361
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
85-398 6.51e-07

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 51.42  E-value: 6.51e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313  85 LFTSSLYLAGLTATFFASYTTRTLGRRLTMLIAGVFFIIGVALNAGAQDLAMLIAGRILLGCGVGFANQAVPLFLSEIAP 164
Cdd:cd17325  35 LIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWPAAMALIADIAP 114
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 165 TRIRGGLNILFQLNVTIGILFANLVnygtakikGG-----WGWRLSLGLAGIPALLLTVGALLVTETPNSLVERGRldeg 239
Cdd:cd17325 115 PEERGRAMGIFSSAIGLGFLIGPLL--------GGlladaLGYRAPFLVCAALALLALVLALLLLPEPRPPPNKRA---- 182
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 240 kavlrrirgtdnvepefadlleasRLAKEVKHPFRNLLQRRNrpqlVIAVALQIFQQCTGINAIMFYAPVLFSTLgFGSD 319
Cdd:cd17325 183 ------------------------VSAARLRSGLRLLLRDRR----LLALFLAIFVLAFAFGALEPFLPLYAAEL-GGLS 233
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 320 ASLYSAVVT--GAVNVLSTLVSIYSVDKVGRRVLlleagvqMFFSQVVIAIILGVkvtdtsTNLSKGFAILVVVMICTYV 397
Cdd:cd17325 234 PAQIGLLFGaqGLASALSQPPAGKLSDRIGRKPL-------ILIGLLLSAVALLL------LPLATSFWLLLLLLALLGL 300

                .
gi 15240313 398 A 398
Cdd:cd17325 301 G 301
MFS_KgtP cd17367
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ...
109-477 1.01e-06

Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340925 [Multi-domain]  Cd Length: 407  Bit Score: 51.14  E-value: 1.01e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 109 GRRLTM-----LIAGVFFIIGVA---LNAGAQDLAMLIAGRILLGCGVGFANQAVPLFLSEIAPTRIRGGLNILFQLNVT 180
Cdd:cd17367  68 GRRAALtlsvsLMAAGSLVIAVTptyATIGIWAPIILLLARLLQGLSVGGEYGTSATYLSEVAPPGRRGFYSSFQYVTLI 147
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 181 IGILFANLVNYGTAKIKGG-----WGWRlslglagIPALLLTVGALLVtetpnslvergrldegkAVLRRIRgtdnvePE 255
Cdd:cd17367 148 GGQLLALGVLLVLQHTLGEdqmaaWGWR-------IPFLLGGVLAVVV-----------------LWLRRGL------EE 197
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 256 FADLLEASRLAKEVKHPFRNLlqRRNRPQLVIAVALqifqqcTGINAIMFYAPV------LFSTLGFGSDASLYSAVVTG 329
Cdd:cd17367 198 TESFEAIAESNEASAGTLREL--RRHPRELLLVVGL------TAGGTLAFYTWTtylqkfLVNTAGFSKGDATWITTAAL 269
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 330 AV-NVLSTLVSIYSvDKVGRRVLLLEAGVqmFFSQVVIAIILGVKVTDTSTNLskgFAILVV--VMICTYVAAFAwswgp 406
Cdd:cd17367 270 LVfMLLQPLGGRLS-DRIGRRPLLLFFGI--GGTLATVPLLSALDHTDSPYTA---FALVLVglVFLSGYTSINA----- 338
                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15240313 407 lgwLIPSETFPLETRSAGQSVTVCV-NLLF---TFIIAQAFLSmlcHFKFGIFIFFSAWVLIMSVFVMFLLPETK 477
Cdd:cd17367 339 ---VVKAELFPTHVRALGVGLPYALaVAIFggtAPYVALWLKS---IGHEWVFFWYVAGLIAISLVVYLRMPETR 407
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
85-236 1.51e-06

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 50.29  E-value: 1.51e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313  85 LFTSSLYLAGLTATFFASYTTRTLGRRLTMLIAGVFFIIGVALNAGAQDLAMLIAGRILLGCGVGFANQAVPLFLSEIAP 164
Cdd:cd17489  35 LVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIP 114
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15240313 165 TRIRGGLNILFQLNVTIG-ILFANLVNYgtakIKGGWGWRLSLGLAGIPALLLTVGALLVTETPNSLVERGRL 236
Cdd:cd17489 115 PSRRGEGIGYYGLATTLAmALGPALGLF----LYQHLGFAVLFIVAAVLALLALLLVFLVKDPPPVAAEEAEA 183
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
83-223 3.72e-06

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 49.08  E-value: 3.72e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313  83 LQLFTSSLYLAGLTATFFASYTTRTLGRRLTMLIAGVFFIIGVALNAGAQDLAMLIAGRILLGCGVGFANQAVPLFLSEI 162
Cdd:COG0738  45 AGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAAL 124
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15240313 163 AP---TRIRGGLNILFQLNVTIGILFANLVnygtAKIKGGWGWRLSLGLAGIPALLLTVGALLV 223
Cdd:COG0738 125 GPetaASRLNLLHAFFSLGALLGPLLGGLL----ILLGLSLSWHLPYLILAVLLLLLALLFLRS 184
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
85-218 6.04e-06

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 48.35  E-value: 6.04e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313  85 LFTSSLYLAGLTATFFASYTTRtLGRRLTMLIAGVFFIIGVALNAGAQDLAMLIAGRILLGCGVGFANQAVPLFLSEIAP 164
Cdd:cd17365  39 VGSAALFGMAIGALLAGPLADR-FGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLGLGAAMPNAITLVSEYAP 117
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 15240313 165 TRIRGGLNILFQLNVTIGilfANLVNYGTAKIKGGWGWRLSLGLAGIPALLLTV 218
Cdd:cd17365 118 ARRRSLAVTLMFCGYPLG---AALGGFLAAALIPAFGWRSVFLLGGVPPLILLP 168
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
78-183 5.56e-05

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 45.35  E-value: 5.56e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313  78 YDNQGLQLFTSSLYLAGLTATFFASYTTRTLGRRLTMLIAGVFFIIGVALNAGAQDLAMLIAGRILLGCGVGFANQAVPL 157
Cdd:COG2814 240 LSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQA 319
                        90       100
                ....*....|....*....|....*.
gi 15240313 158 FLSEIAPTRIRGGLNILFQLNVTIGI 183
Cdd:COG2814 320 LVAELAPPEARGRASGLYNSAFFLGG 345
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
80-169 1.13e-04

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 44.49  E-value: 1.13e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313  80 NQGLQLFTSSLY--LAGLTATFFASYTTRTLGRR----LTMLIAGVFFIIGVALNAGAQDLAMLIAgriLLG-CGVGFAN 152
Cdd:cd17317 188 NLGGNLYLNFFLsgLVEIPAYFLALLLLDRLGRRwtlsGSLLLAGLACLVTALLPDDENTLALTLA---LVGkFAISAAF 264
                        90
                ....*....|....*..
gi 15240313 153 QAVPLFLSEIAPTRIRG 169
Cdd:cd17317 265 SVIYLYTAELYPTVVRN 281
synapt_SV2 TIGR01299
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ...
46-250 1.45e-04

synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.


Pssm-ID: 130366 [Multi-domain]  Cd Length: 742  Bit Score: 44.58  E-value: 1.45e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313    46 GVTSMPDFLEKFfpvVYRKVVAGADKDsnYCkYDNQGLQLFTSSLYLAGLTATFFASYTTRTLGRRLTMLIA----GVFF 121
Cdd:TIGR01299 173 GLALMADGVEVF---VVGFVLPSAEKD--LC-IPDSGKGMLGLIVYLGMMVGAFFWGGLADKLGRKQCLLIClsvnGFFA 246
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313   122 IigvaLNAGAQDLAMLIAGRILLGCGVGFANQAVPLFLSEIAPTRIRGGLNILFQLNVTIGILFANLVNYGtakIKGGWG 201
Cdd:TIGR01299 247 F----FSSFVQGYGFFLFCRLLSGFGIGGAIPIVFSYFAEFLAQEKRGEHLSWLCMFWMIGGIYAAAMAWA---IIPHYG 319
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15240313   202 WRLSLGLA-------------GIPALLLTVGALLVTETPNSLVERGRLDEGKAVLRRIRGTD 250
Cdd:TIGR01299 320 WSFQMGSAyqfhswrvfvivcAFPCVFAIGALTFMPESPRFFLENGKHDEAWMILKLIHDTN 381
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
85-223 1.66e-04

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 44.10  E-value: 1.66e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313  85 LFTSSLYLAGLTATFFASYTTRTLGRRLTMLIAGVFFIIGVALNAGAQDLAMLIAGRILLGCGVGFANQAVPLFLSEIAP 164
Cdd:cd17473 237 LALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVP 316
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 15240313 165 TRIRGGLNILFQLNVTIGILFANLVnyGTAKIKGGWGWRLSLGLAGIPALLLTVGALLV 223
Cdd:cd17473 317 PELRGRAMGIVTSAFFLGQFLSPLV--LGPLVNLTGGLSGAFLILGVLALVLAIVLLLL 373
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
93-372 1.87e-04

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 43.69  E-value: 1.87e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313  93 AGLTATFFASYTTRtLGRRLTMLIAGVFFIIGVALNAGAQDLAMLIAGRILLGCGVGFANQAVPLFLSEIAPTRIRGGLN 172
Cdd:cd17324  47 YALGALLLGPLSDR-IERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAI 125
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 173 ILFQLNVTIGILFANLVnygTAKIKGGWGWRLSLGLAGIPALLLTVGALLvtetpnslvergrldegkaVLRRIRGTDNV 252
Cdd:cd17324 126 GLVFSGLTLGLVLGRPL---GGLLGQLLGWRAAFLAIAVLALLAALLLWR-------------------LLPSLPPKKPG 183
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 253 EPefadlleasrlakevkHPFRNLLQRRNRPQLVIAVALQIFQQCTGINAIMFYAPVLFSTLGFGSDASLYSAVVTGAVN 332
Cdd:cd17324 184 SL----------------GLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAG 247
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 15240313 333 VLSTLVSIYSVDKVGRRVLLLEAGVQM-------FFSQVVIAIILGV 372
Cdd:cd17324 248 VVGSPLAGRLADRGGRRALLIALLLLAaalllltLLGPSPLLLLVGL 294
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
85-223 2.49e-04

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 43.74  E-value: 2.49e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313  85 LFTSSLYLAGLTATFFASYTTRTLGRRLTMLIAGVFFIIGVALN--AGAQDLAMLIAGRILLGCGVGFANQAVPLFLSEI 162
Cdd:COG2211 268 LLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLffLGPGNLWLLLVLAALAGIGLGAILVLPWAMLADV 347
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15240313 163 AP-------TRIRG---GLNILFQ-LNVTIGILFA----NLVNY-GTAKIKGGWGWRLSLGLAGIPALLLTVGALLV 223
Cdd:COG2211 348 VDydewktgRRREGlyfGIFTFAIkLGQALAGALAglllALFGYvAGAAQSPSALTGIRLLFFLLPAVLLLLAALLL 424
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
108-169 3.89e-04

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 42.55  E-value: 3.89e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15240313 108 LGRRLTMLIAGVFFIIGVALNAGAQDLAMLIAGRILLGCGVGFANQAVPLFLSEIAPTRIRG 169
Cdd:cd17502  57 FGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERG 118
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
108-223 4.68e-04

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 42.56  E-value: 4.68e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 108 LGRRLTMLIAGVFFIIGVALNAGAQDLAMLIAGRILLGCGVGFANQAVPLFLSEIAPTRIRGGLNILFQLNVTIGILFAN 187
Cdd:cd17319  65 FGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGP 144
                        90       100       110
                ....*....|....*....|....*....|....*.
gi 15240313 188 LVnygTAKIKGGWGWRLSLGLAGIPALLLTVGALLV 223
Cdd:cd17319 145 PL---SGWLLLLFGWRWAFIIEGLLGLLLAVLWWFY 177
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
109-223 5.80e-04

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 42.18  E-value: 5.80e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 109 GRRLTMLIAGVFFIIGVALNAGAQDLAMLIAGRILLGCGVGfanqAVPLFLS----EIAPTRIRGGLNIL---FQLNVTI 181
Cdd:cd17504  59 GRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRALQGIGGA----VFPLAFAlvreEFPPERVPVAQGILsatFGIGAGI 134
                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 15240313 182 GILF-ANLVNYgtakikggWGWRLSLGLAGIPALLLTVGALLV 223
Cdd:cd17504 135 GLPLgGWIVQH--------LGWRWIFWTAAPVAVLLAALVPLI 169
MFS_SVOP_like cd17372
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ...
85-218 5.90e-04

Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340930 [Multi-domain]  Cd Length: 367  Bit Score: 42.14  E-value: 5.90e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313  85 LFTSSLYLAGLTATFFASYTTRTLGRRLTMLIAGVFFIIGVALNAGAQDLAMLIAGRILLGCGVGFANQAVPLFLsEIAP 164
Cdd:cd17372  38 LITSVVFAGMMIGSYLWGIVSDKYGRRKGLIISALWTFYAGFLSAFAPNYMWLIILRCLVGLGLGGGPQLASWYL-EFLP 116
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 15240313 165 TRIRGGLNILFQLNVTIGILF-ANLVNYGTAKIkggwGWRLSLGLAGIPALLLTV 218
Cdd:cd17372 117 AKSRGTWMVLFSVFWTVGTIFeASLAWLVMPRL----GWRWLLAFSSVPSSLLLV 167
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
100-182 7.16e-04

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 41.79  E-value: 7.16e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 100 FASYTTRTLGRRLTMLIAGVFFIIGVALNAGAQDLAMLIAGRILLGCGVGFANQAVPLFLSEIAPTRIRGGLNILFQLNV 179
Cdd:cd17503  50 LSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVI 129

                ...
gi 15240313 180 TIG 182
Cdd:cd17503 130 LLA 132
MFS_SV2 cd17363
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic ...
46-250 7.20e-04

Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. The SV2 family belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340921 [Multi-domain]  Cd Length: 474  Bit Score: 42.09  E-value: 7.20e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313  46 GVTSMPDFLEKFfpvVYRKVVAGADKDsnYCkYDNQGLQLFTSSLYLAGLTATFFASYTTRTLGRRLTMLIAGVFFIIGV 125
Cdd:cd17363   5 GLALMADGVEVF---VVGFVLPSAEKD--MC-LSNSNKGMLGLIVYLGMMVGAFVWGGLADKLGRKQCLLIALSVNGVFA 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 126 ALNAGAQDLAMLIAGRILLGCGVGFANQAVPLFLSEIAPTRIRGGLNILFQLNVTIGILFANLVNYGTAKiKGGWG---- 201
Cdd:cd17363  79 FLSSFVQGYGFFLFCRLLSGIGIGGSIPIVFSYFAEFLAREKRGEHLSWLCMFWMIGGLYASAMAWAIIP-HYGWGfsmg 157
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 15240313 202 -------WRLSLGLAGIPALLLTVGALLVTETPNSLVERGRLDEGKAVLRRIRGTD 250
Cdd:cd17363 158 tayqfhsWRVFVIVCALPSVASVVALTFMPESPRFLLEVGKHDEAWMILKQVHDTN 213
2A0109 TIGR00887
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the ...
99-484 7.88e-04

phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the major facilitator superfamily (pfam00083). [Transport and binding proteins, Anions]


Pssm-ID: 129965 [Multi-domain]  Cd Length: 502  Bit Score: 42.02  E-value: 7.88e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313    99 FFASYTTRTLGRR----LTMLIAgVFFIIGVALNAGAQDL---AMLIAGRILLGCGVGFANQAVPLFLSEIAPTRIRG-- 169
Cdd:TIGR00887  74 LFFGWLADKLGRKrvygMELIIM-IIATVASGLSPGSSPKsvmATLCFWRFWLGVGIGGDYPLSAIITSEFATKKWRGam 152
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313   170 --------GLNILFQLNVTIGIL--FANLVNY--------GTAKIKGGWGWRLSLGLAGIPALLLTVGALLVTETP--NS 229
Cdd:TIGR00887 153 maavfamqGFGILAGAIVALIVLagFKHSLEAaadeasctGSCVPAVDYMWRILIGFGAVPALLALYFRLTIPETPryTA 232
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313   230 LVERGRLDEGKAVLRRIRGTDNVEPEfadllEASRLAKEVKHP-------FRNLLQRRNrPQLVIAVALQIFqqctgINA 302
Cdd:TIGR00887 233 DVAKDVEQAASDMSAVLQVKIEAEPD-----EVEKASTAVEVPkaswsdfFTHFFKWRH-GKHLLGTAGSWF-----LLD 301
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313   303 IMFYA-----PVLFSTLGFGSDAS---LYSAVVTGAV-NVLSTL--------VSIYSVDKVGRRVLLLeagvQMFFSQVV 365
Cdd:TIGR00887 302 IAFYGvnlnqKVILSAIGYSPPAAtnnAYEELYKTAVgNLIIALagtvpgywVTVFLVDIIGRKPIQL----MGFFILTV 377
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313   366 IAIILGVKVTDTSTnlsKGFAILVVVmictyvAAFAWSWGP--LGWLIPSETFPLETRSAGQSVTVCVNLLFTFIIAQAF 443
Cdd:TIGR00887 378 LFFVLGFAYNHLST---HGFLAIYVL------AQFFANFGPnaTTFIVPGEVFPTRYRSTAHGISAASGKAGAIIGQFGF 448
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|..
gi 15240313   444 LSMLCH------FKFGIF-----IFFSAWVLImSVFVMFLLPETKNIPIEEM 484
Cdd:TIGR00887 449 LYLAQHgdptkgYPTGIWmghvlEIFALFMFL-GILFTLLIPETKGKSLEEL 499
MFS_SV2B cd17438
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ...
46-250 1.27e-03

Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340996 [Multi-domain]  Cd Length: 477  Bit Score: 41.45  E-value: 1.27e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313  46 GVTSMPDFLEKFfpvVYRKVVAGADKDSNYCKYDNQGLQLFtssLYLAGLTATFFASYTTRTLGRRLTMLIAGVFFIIGV 125
Cdd:cd17438   5 GLALMADGVEVF---VVGFVLPSAEKDMCLSSSNKGMLGLI---VYLGMMAGAFIWGGLADKLGRKRCLIISLAINASFA 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 126 ALNAGAQDLAMLIAGRILLGCGVGFANQAVPLFLSEIAPTRIRGGLNILFQLNVTIGILFANLVNYGTAKiKGGWG---- 201
Cdd:cd17438  79 FLSSFVQGYGAFLFCRLISGFGIGGSLPIVFAYFSEFLAREKRGEHLSWLCMFWMIGGLYASAMAWSIIP-HYGWGfsmg 157
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 15240313 202 -------WRLSLGLAGIPALLLTVGALLVTETPNSLVERGRLDEGKAVLRRIRGTD 250
Cdd:cd17438 158 tnyhfhsWRVFVIICALPCIASIIALKFMPESPRFLLEMGKHDEAWMILKNIHDTN 213
MFS_unc93_like cd17338
Unc-93 family of the Major Facilitator Superfamily of transporters; The Unc-93 family is ...
90-366 1.46e-03

Unc-93 family of the Major Facilitator Superfamily of transporters; The Unc-93 family is composed of Caenorhabditis elegans uncoordinated protein 93 (also called putative potassium channel regulatory protein unc-93) and similar proteins including three vertebrate members: protein unc-93 homolog A (UNC93A), protein unc-93 homolog B1 (UNC93B1), and UNC93-like protein MFSD11 (also called major facilitator superfamily domain-containing protein 11 or protein ET). Unc-93 acts as a regulatory subunit of a multi-subunit potassium channel complex that may function in coordinating muscle contraction in C. elegans. The human UNC93A gene is located in a region of the genome that is frequently associated with ovarian cancer, however, there is no evidence that UNC93A has a tumor suppressor function. UNC93B1 controls intracellular trafficking and transport of a subset of Toll-like receptors (TLRs), including TLR3, TLR7 and TLR9, from the endoplasmic reticulum to endolysosomes where they can engage pathogen nucleotides and activate signaling cascades. MFSD11 is ubiquitously expressed in the periphery and the central nervous system of mice, where it is expressed in excitatory and inhibitory mouse brain neurons. The unc93-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340896 [Multi-domain]  Cd Length: 388  Bit Score: 41.18  E-value: 1.46e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313  90 LYLAGLTATFFASYTTRTLGRRLTMLIAGVFFIIGVALNAGAQDLAMLIAGrILLGCGVGFANQAVPLFLSEIAPTRIRG 169
Cdd:cd17338  38 LYSSFAVSSFIAPLLVKLLGEKITLVLGGLGYAIFIASNIFPIWGTLVPAS-IILGFAAAILWTAQGTYITRISDESNIG 116
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 170 GLNILFQLNVTIGILFANLVNYGTAKIKGGWGWRLSLGLA-GIPALLLTVGALLvtetpnslvergrldegkavLRRIRG 248
Cdd:cd17338 117 RNFGIFWSIFQLSQVFGNLISLALLNHSKGSSGTTILFIVfMAIMLVGIILLFF--------------------LRGPDN 176
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 249 TDNVEPEFADLLEASRLAKEVKHPFRNLLQRRNRpQLVIAVALQIFQQ---CTGINAIMFYAPVLFSTLGfgsdaslYSA 325
Cdd:cd17338 177 EVITEIESSSVGESMEKKNLFKLPFTLLKDKRFL-LLIPLLIYSGLEQtffSGVFTLIIGTPTTGIARVG-------YVM 248
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 15240313 326 VVTGAVNVLSTLV-SIYSVDKVGRRVLLLEAGVQMFFSQVVI 366
Cdd:cd17338 249 AVYGFGDALGSLVaGLLSDWRFGRIVLAVIGAFVHIASLILL 290
MFS_2 pfam13347
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ...
75-222 1.47e-03

MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.


Pssm-ID: 433134 [Multi-domain]  Cd Length: 427  Bit Score: 41.14  E-value: 1.47e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313    75 YCKY---DNQGLQLFTSSLYLAGLTATFFASYTTRTLGRR----LTMLIAGVFFIIGVALnaGAQDLAMLIAGRILLGCG 147
Cdd:pfam13347 250 YFRYvlgNGFAASAFPLVFTIGALLGIPLWPPLAKRIGKKntyiLGALITIAGFALALLL--GPNNTLLFLVLYIIIGFG 327
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313   148 VGFANQAVPLFLSEIA-------PTRIRGGLNILFQLNVTIGILFANLV----------NYGTAKIKGGWGWRLSLGLAG 210
Cdd:pfam13347 328 YGSSFFLPWSMLADVVdygelrtGKRREGTFFAMWSFISKLATGVGLGVsglllsafgyNAGDSVQSPQAVTAIRLLYAV 407
                         170
                  ....*....|..
gi 15240313   211 IPALLLTVGALL 222
Cdd:pfam13347 408 LPAVLFLVALLL 419
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
92-222 1.67e-03

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 40.64  E-value: 1.67e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313  92 LAGLTATFFASYTTRTLGRRLTMLIAGVFFIIGVALNAGAQDLAMLIAGRILLGCGVGFANQAVPLFLSEIAPTRIRGGL 171
Cdd:cd17325 246 LASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTA 325
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 15240313 172 NILFQLNVTIGILFANLVnygTAKIKGGWGWRLSLGLAGIPALLLTVGALL 222
Cdd:cd17325 326 MGLFNTAFSLGMVLGPLL---GGFLYDAFGFATPFLAAAALLLLAAVLFLL 373
MFS_NIMT_CynX_like cd17339
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator ...
100-222 3.36e-03

2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340897 [Multi-domain]  Cd Length: 374  Bit Score: 39.87  E-value: 3.36e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 100 FASYTTRTLGRRLTMLIAGVFFIIGVALNAGAQdLAMLIAGRILLGCGVGFANQAVPLFLSEIAPTRIrGGLNILFQLNV 179
Cdd:cd17339  53 LAPRLARRFGLERTLLLALLLLAAGILLRSLGG-IALLFLGTALAGAGIAVGNVLLPSLIKRDFPRRV-GLMTGLYTTSM 130
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 15240313 180 TIGilfANLVNYGTAKI--KGGWGWRLSLGLAGIPALLLTVGALL 222
Cdd:cd17339 131 NLG---AALASGLSVPLaqALGGGWRGALAIWALPALLALLIWLP 172
MFS_SV2C cd17440
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; ...
80-250 3.78e-03

Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2C exhibits enriched expression in several basal ganglia nuclei, and has been found to be involved in normal operation of the basal ganglia network and could be also be involved in system adaptation in basal ganglia pathological conditions. SV2C belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340998 [Multi-domain]  Cd Length: 479  Bit Score: 39.90  E-value: 3.78e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313  80 NQGLQLFTSSLYLAGLTATFFASYTTRTLGRRLTMLIAGVFFIIGVALNAGAQDLAMLIAGRILLGCGVGFANQAVPLFL 159
Cdd:cd17440  33 NSGSGWLGSIVYLGMMVGAFFWGGLADKVGRRQSLLICMSVNGFFAFLSSFVQGYGLFLFCRLLSGFGIGGAVPTVFSYF 112
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313 160 SEIAPTRIRGGLNILFQLNVTIGILFANLVNYGtakIKGGWGWRLSLGLA-------------GIPALLLTVGALLVTET 226
Cdd:cd17440 113 AEVLAREKRGEHLSWLCMFWMIGGIYASAMAWA---IIPHYGWSFSMGSAyqfhswrvfvivcALPCVSSVVALTFMPES 189
                       170       180
                ....*....|....*....|....
gi 15240313 227 PNSLVERGRLDEGKAVLRRIRGTD 250
Cdd:cd17440 190 PRFLLEVGKHDEAWMILKQIHDTN 213
MFS_SVOP cd17441
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic ...
85-226 5.14e-03

Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein (SVOP) is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. This SVOP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340999 [Multi-domain]  Cd Length: 372  Bit Score: 39.41  E-value: 5.14e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313  85 LFTSSLYLAGLTATFFASYTTRTLGRRLTMLIAGVFFIIGVALNAGAQDLAMLIAGRILLGCGVGFANQAVPLFlSEIAP 164
Cdd:cd17441  38 LLTSVVFIGMMLSSSLWGNISDQYGRKTGLKISVLWTLYYGILSAFAPIYSWILVLRGLVGFGIGGVPQSVTLY-AEFLP 116
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15240313 165 TRIRGGLNILFQLNVTIGILFANLVNYgtaKIKGGWGWRLSLGLAGIPALLLTVGALLVTET 226
Cdd:cd17441 117 MKSRAKCILLIEVFWALGTVFEVLLAV---FVMPTLGWRWLLILSALPLLIFAVLCFWLPES 175
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
91-224 5.26e-03

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 39.07  E-value: 5.26e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240313  91 YLAGLTATFFASYTTRTLGRRLTMLIAGVFFIIGVALNAGAQDLAMLIAGRILLGCGVGFANQAVPLFLSEIAPtRIRGG 170
Cdd:cd17324 244 GVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAP-EARGL 322
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 15240313 171 LNILFQLNVTIGILFANLVnygtakikGGWGW-RLSLGLAGIPALLLTVGALLVT 224
Cdd:cd17324 323 ASSLYLAAYNLGGALGAAL--------GGLVLdHGGWAGVGWVGAALLLLALLLA 369
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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