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    Rnf180 ring finger protein 180 [ Mus musculus (house mouse) ]

    Gene ID: 71816, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rnf180provided by MGI
    Official Full Name
    ring finger protein 180provided by MGI
    Primary source
    MGI:MGI:1919066
    See related
    Ensembl:ENSMUSG00000021720 AllianceGenome:MGI:1919066
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rines; 3110001E11Rik
    Summary
    Enables ubiquitin conjugating enzyme binding activity and ubiquitin protein ligase activity. Acts upstream of or within several processes, including norepinephrine metabolic process; positive regulation of protein metabolic process; and serotonin metabolic process. Located in endoplasmic reticulum membrane. Is expressed in several structures, including adrenal medulla; central nervous system; genitourinary system; lens; and thymus. Orthologous to human RNF180 (ring finger protein 180). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in genital fat pad adult (RPKM 6.2), CNS E18 (RPKM 4.7) and 15 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rnf180 in Genome Data Viewer
    Location:
    13 56.92 cM; 13 D1
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (105267075..105431406, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (105130567..105294818, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene regulator of G-protein signalling 7 binding protein Neighboring gene 5' nucleotidase, ecto-like Neighboring gene STARR-positive B cell enhancer ABC_E7275 Neighboring gene STARR-seq mESC enhancer starr_35548 Neighboring gene STARR-seq mESC enhancer starr_35549 Neighboring gene predicted gene, 25631 Neighboring gene STARR-seq mESC enhancer starr_35551 Neighboring gene predicted gene, 41049 Neighboring gene predicted gene, 31130

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. E3 ubiquitin ligase RNF180 mediates the ALKBH5/SMARCA5 axis to promote colon inflammation and Th17/Treg imbalance in ulcerative colitis mice. Wang K, et al. Arch Pharm Res, 2024 Jul. PMID 39060657
    2. RING finger gene 180 inhibits osteosarcoma progression through regulating chromobox homolog 4 ubiquitination. Zhao Q, et al. Cell Cycle, 2023 May. PMID 37095741, Free PMC Article
    3. Rines E3 ubiquitin ligase regulates MAO-A levels and emotional responses. Kabayama M, et al. J Neurosci, 2013 Aug 7. PMID 23926250, Free PMC Article
    4. Rines/RNF180, a novel RING finger gene-encoded product, is a membrane-bound ubiquitin ligase. Ogawa M, et al. Genes Cells, 2008 Apr. PMID 18363970
    5. A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract. Wiese CB, et al. Front Neurosci, 2012. PMID 22988430, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. E3 ubiquitin ligase RNF180 mediates the ALKBH5/SMARCA5 axis to promote colon inflammation and Th17/Treg imbalance in ulcerative colitis mice.
      Title: E3 ubiquitin ligase RNF180 mediates the ALKBH5/SMARCA5 axis to promote colon inflammation and Th17/Treg imbalance in ulcerative colitis mice.
    2. RING finger gene 180 inhibits osteosarcoma progression through regulating chromobox homolog 4 ubiquitination.
      Title: RING finger gene 180 inhibits osteosarcoma progression through regulating chromobox homolog 4 ubiquitination.
    3. Rines is a critical regulator of the monoaminergic system and emotional behavior and identify a promising candidate drug target for treating diseases associated with emotion.
      Title: Rines E3 ubiquitin ligase regulates MAO-A levels and emotional responses.
    4. The involvement of RNF180 in the ubiquitin-proteasome pathway was further supported by its binding to the UbcH6 ubiquitin-conjugating enzyme and by its trans-ubiquitination enhancing activities.
      Title: Rines/RNF180, a novel RING finger gene-encoded product, is a membrane-bound ubiquitin ligase.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin conjugating enzyme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin conjugating enzyme binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within adult behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in norepinephrine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within norepinephrine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of proteasomal ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within protein polyubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of catalytic activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in serotonin metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within serotonin metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear envelope IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase RNF180
    Names
    RING-type E3 ubiquitin transferase RNF180
    NP_001347819.1
    NP_001347820.1
    NP_082210.1
    XP_006517819.1
    XP_006517822.1
    XP_006517823.1
    XP_006517824.4
    XP_011242998.2
    XP_017171096.1
    XP_030103272.1
    XP_030103273.1
    XP_030103274.1
    XP_036014060.1
    XP_036014061.1
    XP_036014062.1
    XP_036014063.1
    XP_036014064.1
    XP_036014065.1
    XP_036014066.1
    XP_036014067.1
    XP_036014068.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360890.1 → NP_001347819.1  E3 ubiquitin-protein ligase RNF180 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC154203, BC075700
      Consensus CDS
      CCDS88517.1
      Related
      ENSMUSP00000153478.2, ENSMUST00000226044.2
      Conserved Domains (1) summary
      cd16554
      Location:431 → 473
      RING-HC_RNF180; RING finger, HC subclass, found in RING finger protein 180 (RNF180) and similar proteins

    2. NM_001360891.1 → NP_001347820.1  E3 ubiquitin-protein ligase RNF180 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC154203, AC175380, AK151379, CJ302269
      Consensus CDS
      CCDS88518.1
      UniProtKB/Swiss-Prot
      Q3U827, Q3UW39, Q80ZX1, Q8CCR1, Q9CXV6
      Related
      ENSMUSP00000153506.2, ENSMUST00000224662.2
      Conserved Domains (1) summary
      cd16554
      Location:432 → 474
      RING-HC_RNF180; RING finger, HC subclass, found in RING finger protein 180 (RNF180) and similar proteins

    3. NM_027934.2 → NP_082210.1  E3 ubiquitin-protein ligase RNF180 isoform 1

      See identical proteins and their annotated locations for NP_082210.1

      Status: VALIDATED

      Source sequence(s)
      AK136632
      Consensus CDS
      CCDS36775.1
      UniProtKB/Swiss-Prot
      Q3U827
      Related
      ENSMUSP00000153678.2, ENSMUST00000224011.2
      Conserved Domains (1) summary
      cd00162
      Location:431 → 477
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      105267075..105431406 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030247413.2 → XP_030103273.1  E3 ubiquitin-protein ligase RNF180 isoform X5

      UniProtKB/Swiss-Prot
      Q3U827, Q3UW39, Q80ZX1, Q8CCR1, Q9CXV6
      Conserved Domains (1) summary
      cd16554
      Location:432 → 474
      RING-HC_RNF180; RING finger, HC subclass, found in RING finger protein 180 (RNF180) and similar proteins

    2. XM_017315607.3 → XP_017171096.1  E3 ubiquitin-protein ligase RNF180 isoform X6

      UniProtKB/Swiss-Prot
      Q3U827
      Conserved Domains (1) summary
      cd16554
      Location:431 → 473
      RING-HC_RNF180; RING finger, HC subclass, found in RING finger protein 180 (RNF180) and similar proteins

    3. XM_006517759.5 → XP_006517822.1  E3 ubiquitin-protein ligase RNF180 isoform X5

      See identical proteins and their annotated locations for XP_006517822.1

      UniProtKB/Swiss-Prot
      Q3U827, Q3UW39, Q80ZX1, Q8CCR1, Q9CXV6
      Conserved Domains (1) summary
      cd16554
      Location:432 → 474
      RING-HC_RNF180; RING finger, HC subclass, found in RING finger protein 180 (RNF180) and similar proteins

    4. XM_030247414.1 → XP_030103274.1  E3 ubiquitin-protein ligase RNF180 isoform X6

      Conserved Domains (1) summary
      cd16554
      Location:431 → 473
      RING-HC_RNF180; RING finger, HC subclass, found in RING finger protein 180 (RNF180) and similar proteins

    5. XM_030247412.1 → XP_030103272.1  E3 ubiquitin-protein ligase RNF180 isoform X4

      Conserved Domains (1) summary
      cd16554
      Location:432 → 474
      RING-HC_RNF180; RING finger, HC subclass, found in RING finger protein 180 (RNF180) and similar proteins

    6. XM_006517756.4 → XP_006517819.1  E3 ubiquitin-protein ligase RNF180 isoform X3

      Conserved Domains (1) summary
      cd16554
      Location:433 → 475
      RING-HC_RNF180; RING finger, HC subclass, found in RING finger protein 180 (RNF180) and similar proteins

    7. XM_006517760.3 → XP_006517823.1  E3 ubiquitin-protein ligase RNF180 isoform X5

      See identical proteins and their annotated locations for XP_006517823.1

      UniProtKB/Swiss-Prot
      Q3U827, Q3UW39, Q80ZX1, Q8CCR1, Q9CXV6
      Conserved Domains (1) summary
      cd16554
      Location:432 → 474
      RING-HC_RNF180; RING finger, HC subclass, found in RING finger protein 180 (RNF180) and similar proteins

    8. XM_006517761.5 → XP_006517824.4  E3 ubiquitin-protein ligase RNF180 isoform X1

      Conserved Domains (1) summary
      cd16554
      Location:481 → 523
      RING-HC_RNF180; RING finger, HC subclass, found in RING finger protein 180 (RNF180) and similar proteins

    9. XM_011244696.4 → XP_011242998.2  E3 ubiquitin-protein ligase RNF180 isoform X2

      Conserved Domains (1) summary
      cd16554
      Location:480 → 522
      RING-HC_RNF180; RING finger, HC subclass, found in RING finger protein 180 (RNF180) and similar proteins

    10. XM_036158170.1 → XP_036014063.1  E3 ubiquitin-protein ligase RNF180 isoform X9

      Conserved Domains (1) summary
      cd16554
      Location:431 → 473
      RING-HC_RNF180; RING finger, HC subclass, found in RING finger protein 180 (RNF180) and similar proteins

    11. XM_036158171.1 → XP_036014064.1  E3 ubiquitin-protein ligase RNF180 isoform X9

      Conserved Domains (1) summary
      cd16554
      Location:431 → 473
      RING-HC_RNF180; RING finger, HC subclass, found in RING finger protein 180 (RNF180) and similar proteins

    12. XM_036158168.1 → XP_036014061.1  E3 ubiquitin-protein ligase RNF180 isoform X8

      Conserved Domains (1) summary
      cd16554
      Location:480 → 522
      RING-HC_RNF180; RING finger, HC subclass, found in RING finger protein 180 (RNF180) and similar proteins

    13. XM_036158169.1 → XP_036014062.1  E3 ubiquitin-protein ligase RNF180 isoform X7

      Conserved Domains (1) summary
      cd16554
      Location:432 → 474
      RING-HC_RNF180; RING finger, HC subclass, found in RING finger protein 180 (RNF180) and similar proteins

    14. XM_036158167.1 → XP_036014060.1  E3 ubiquitin-protein ligase RNF180 isoform X7

      Conserved Domains (1) summary
      cd16554
      Location:432 → 474
      RING-HC_RNF180; RING finger, HC subclass, found in RING finger protein 180 (RNF180) and similar proteins

    15. XM_036158175.1 → XP_036014068.1  E3 ubiquitin-protein ligase RNF180 isoform X12

    16. XM_036158172.1 → XP_036014065.1  E3 ubiquitin-protein ligase RNF180 isoform X10

    17. XM_036158174.1 → XP_036014067.1  E3 ubiquitin-protein ligase RNF180 isoform X12

    18. XM_036158173.1 → XP_036014066.1  E3 ubiquitin-protein ligase RNF180 isoform X11

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3U827.2 GenPept UniProtKB/Swiss-Prot:Q3U827

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