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    ACA1 alpha carbonic anhydrase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 824438, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ACA1
    Official Full Name
    alpha carbonic anhydrase 1
    Primary source
    TAIR:AT3G52720
    Locus tag
    AT3G52720
    See related
    Araport:AT3G52720
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    A. THALIANA ALPHA CARBONIC ANHYDRASE 1; alpha carbonic anhydrase 1; ATACA1; CAH1; CARBONIC ANHYDRASE 1
    Summary
    Encodes an alpha carbonic anhydrase (CAH1) located in the chloroplast stroma. Most chloroplast proteins are encoded by the nuclear genome and imported with the help of sorting signals that are intrinsic parts of the polypeptides. CAH1 takes an alternative route through the secretory pathway, and becomes N-glycosylated before entering the chloroplast. Glycosylation and intra-molecular disulfide bridge fromation are necessary for the correct folding, ER export, trafficking and activity of the protein.
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    Genomic context

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    See ACA1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    7
    Sequence:
    Chromosome: 3; NC_003074.8 (19538540..19542286, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene pseudo Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene ubiquinol-cytochrome C reductase UQCRX/QCR9-like family protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Importance of post-translational modifications for functionality of a chloroplast-localized carbonic anhydrase (CAH1) in Arabidopsis thaliana. Burén S, et al. PLoS One, 2011. PMID 21695217, Free PMC Article
    2. Evidence for a protein transported through the secretory pathway en route to the higher plant chloroplast. Villarejo A, et al. Nat Cell Biol, 2005 Dec. PMID 16284624
    3. Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana. Salanoubat M, et al. Nature, 2000 Dec 14. PMID 11130713

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the importance of post-translational modifications such as N-glycosylation and intramolecular disulphide bridge formation in folding and trafficking of CAH1
      Title: Importance of post-translational modifications for functionality of a chloroplast-localized carbonic anhydrase (CAH1) in Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    General gene information

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    NM_001339583.1
    NM_001339584.1
    NM_115132.3
    NM_180354.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables carbonate dehydratase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chloroplast stroma IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    alpha carbonic anhydrase 1
    NP_001319732.1
    • alpha carbonic anhydrase 1 (ACA1); FUNCTIONS IN: carbonate dehydratase activity, zinc ion binding; INVOLVED IN: one-carbon metabolic process; LOCATED IN: chloroplast stroma; EXPRESSED IN: 20 plant structures; EXPRESSED DURING: 11 growth stages; CONTAINS InterPro DOMAIN/s: Carbonic anhydrase, alpha-class, catalytic domain (InterPro:IPR001148), Carbonic anhydrase, CAH1-like (InterPro:IPR018340), Carbonic anhydrase, alpha-class, conserved site (InterPro:IPR018338); BEST Arabidopsis thaliana protein match is: alpha carbonic anhydrase 7 (TAIR:AT1G08080.1); Has 3348 Blast hits to 3336 proteins in 547 species: Archae - 0; Bacteria - 715; Metazoa - 2044; Fungi - 83; Plants - 327; Viruses - 0; Other Eukaryotes - 179 (source: NCBI BLink).
    NP_850685.1
    • alpha carbonic anhydrase 1 (ACA1); FUNCTIONS IN: carbonate dehydratase activity, zinc ion binding; INVOLVED IN: one-carbon metabolic process; LOCATED IN: chloroplast stroma; EXPRESSED IN: 20 plant structures; EXPRESSED DURING: 11 growth stages; CONTAINS InterPro DOMAIN/s: Carbonic anhydrase, alpha-class, catalytic domain (InterPro:IPR001148), Carbonic anhydrase, CAH1-like (InterPro:IPR018340), Carbonic anhydrase, alpha-class, conserved site (InterPro:IPR018338); BEST Arabidopsis thaliana protein match is: alpha carbonic anhydrase 2 (TAIR:AT2G28210.1); Has 3162 Blast hits to 3153 proteins in 518 species: Archae - 0; Bacteria - 691; Metazoa - 1922; Fungi - 83; Plants - 314; Viruses - 0; Other Eukaryotes - 152 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      19538540..19542286 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001339583.1 → NP_001319732.1  alpha carbonic anhydrase 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B9DH12, F4J831, O04846, Q940K9
      UniProtKB/TrEMBL
      A0A178V615, A0A5S9XKG2
      Conserved Domains (1) summary
      cl00012
      Location:1 → 284
      alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...

    2. NM_115132.3 → NP_566971.2  alpha carbonic anhydrase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_566971.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B9DH12, F4J831, O04846, Q940K9
      UniProtKB/TrEMBL
      A0A178V615, A0A5S9XKG2
      Conserved Domains (1) summary
      cl00012
      Location:1 → 284
      alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...

    3. NM_001339584.1 → NP_001326182.1  alpha carbonic anhydrase 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B9DH12, F4J831, O04846, Q940K9
      UniProtKB/TrEMBL
      A0A178V615, A0A5S9XKG2
      Conserved Domains (1) summary
      cl00012
      Location:1 → 284
      alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...

    4. NM_180354.2 → NP_850685.1  alpha carbonic anhydrase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_850685.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O04846
      Conserved Domains (2) summary
      PLN02179
      Location:2 → 230
      PLN02179; carbonic anhydrase
      cl00012
      Location:1 → 228
      alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O04846.2

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