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Conserved domains on  [gi|30693691|ref|NP_850685|]
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alpha carbonic anhydrase 1 [Arabidopsis thaliana]

Protein Classification

carbonic anhydrase family protein( domain architecture ID 275)

carbonic anhydrase family protein similar to carbonic anhydrase, which catalyzes the reversible hydration of gaseous carbon dioxide to carbonic acid

CATH:  3.10.200.10
Gene Ontology:  GO:0004089|GO:0008270|GO:0006730
PubMed:  10978542|18336305
SCOP:  4002732

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
alpha_CA super family cl00012
Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are ...
 1-228 2.68e-170

Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionary distinct groups - alpha, beta and gamma carbonic anhydrases - which show no significant sequence identity or structural similarity. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidine residues and a fourth conserved histidine plays a potential role in proton transfer.


The actual alignment was detected with superfamily member PLN02202:

Pssm-ID: 469577 [Multi-domain]  Cd Length: 284  Bit Score: 469.92  E-value: 2.68e-170
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30693691    1 MKIMMMIKLCFFSMSLICIAPADAQTEGVVFGYKGKNGPNQWGHLNPHFTTCAVGKLQSPIDIQRRQIFYNHKLNSIHRE 80
Cdd:PLN02202   1 MKIMMMIKLCFFAIALICIAPADAQTEGVVFGYKGKNGPNQWGHLNPHFTKCAVGKLQSPIDIQRRQIFYNHKLESIHRD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30693691   81 YYFTNATLVNHVCNVAMFFGEGAGDVIIENKNYTLLQMHWHTPSEHHLHGVQYAAELHMVHQAKDGSFAVVASLFKIGTE 160
Cdd:PLN02202  81 YYFTNATLVNHVCNVAMFFGEGAGDVIIDNKNYTLLQMHWHTPSEHHLHGVQYAAELHMVHQAKDGSFAVVASLFKIGTE 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 30693691  161 EPFLSQMKEKLVKLKEERLKGNHTAQVEVGRIDTRHIERKTRKYYRYIGSLTTPPCSENVSWTILGKV 228
Cdd:PLN02202 161 EPFLSQMKDKLVKLKEERFKGNHTAQVEVGKIDTRHIERKTRKYFRYIGSLTTPPCSENVSWTILGKV 228
 
Name Accession Description Interval E-value
PLN02202 PLN02202
carbonate dehydratase
 1-228 2.68e-170

carbonate dehydratase


Pssm-ID: 177853 [Multi-domain]  Cd Length: 284  Bit Score: 469.92  E-value: 2.68e-170
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30693691    1 MKIMMMIKLCFFSMSLICIAPADAQTEGVVFGYKGKNGPNQWGHLNPHFTTCAVGKLQSPIDIQRRQIFYNHKLNSIHRE 80
Cdd:PLN02202   1 MKIMMMIKLCFFAIALICIAPADAQTEGVVFGYKGKNGPNQWGHLNPHFTKCAVGKLQSPIDIQRRQIFYNHKLESIHRD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30693691   81 YYFTNATLVNHVCNVAMFFGEGAGDVIIENKNYTLLQMHWHTPSEHHLHGVQYAAELHMVHQAKDGSFAVVASLFKIGTE 160
Cdd:PLN02202  81 YYFTNATLVNHVCNVAMFFGEGAGDVIIDNKNYTLLQMHWHTPSEHHLHGVQYAAELHMVHQAKDGSFAVVASLFKIGTE 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 30693691  161 EPFLSQMKEKLVKLKEERLKGNHTAQVEVGRIDTRHIERKTRKYYRYIGSLTTPPCSENVSWTILGKV 228
Cdd:PLN02202 161 EPFLSQMKDKLVKLKEERFKGNHTAQVEVGKIDTRHIERKTRKYFRYIGSLTTPPCSENVSWTILGKV 228
alpha_CA_prokaryotic_like cd03124
Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are ...
 38-229 1.72e-77

Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidines. This sub-family includes bacterial carbonic anhydrase alpha, as well as plant enzymes such as tobacco nectarin III and yam dioscorin and, carbonic anhydrases from molluscs, such as nacrein, which are part of the organic matrix layer in shells. Other members of this family may be involved in maintaining pH balance, in facilitating transport of carbon dioxide or carbonic acid, or in sensing carbon dioxide levels in the environment. Dioscorin is the major storage protein of yam tubers and may play a role as an antioxidant. Tobacco Nectarin may play a role in the maintenace of pH and oxidative balance in nectar. Mollusc nacrein may participate in calcium carbonate crystal formation of the nacreous layer. This subfamily also includes three alpha carbonic anhydrases from Chlamydomonas reinhardtii (CAH 1-3). CAHs1-2 are localized in the periplasmic space. CAH1 faciliates the movement of carbon dioxide across the plasma membrane when the medium is alkaline. CAH3 is localized to the thylakoid lumen and provides CO2 to Rubisco.


Pssm-ID: 239398 [Multi-domain]  Cd Length: 216  Bit Score: 232.16  E-value: 1.72e-77
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30693691  38 GPNQWGHLNPHFTTCAVGKLQSPIDIQRRQIFYNHkLNSIHREYYFTNATLVNHVCNVAMFFGEGAGDVIIENKNYTLLQ 117
Cdd:cd03124   1 GPEHWGNLDPEFALCATGKNQSPIDITTKAVVSDK-LPPLNYNYKPTSATLVNNGHTIQVNFEGNGGTLTIDGETYQLLQ 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30693691 118 MHWHTPSEHHLHGVQYAAELHMVHQAKDGSFAVVASLFKIGTEEPFLSQMKEKLVKLKEErlkgnhTAQVEVGrIDTRHI 197
Cdd:cd03124  80 FHFHSPSEHLINGKRYPLEAHLVHKSKDGQLAVVAVLFEEGKENPFLKKILDNMPKKEGT------EVNLPAI-LDPNEL 152

                       170       180       190
                ....*....|....*....|....*....|..
gi 30693691 198 ERKTRKYYRYIGSLTTPPCSENVSWTILGKVI 229
Cdd:cd03124 153 LPESRSYYRYEGSLTTPPCSEGVRWIVLKQPI 184
Cah COG3338
Carbonic anhydrase [Inorganic ion transport and metabolism];
4-225 4.63e-61

Carbonic anhydrase [Inorganic ion transport and metabolism];


Pssm-ID: 442567 [Multi-domain]  Cd Length: 247  Bit Score: 191.64  E-value: 4.63e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30693691   4 MMMIKLCFFSMSLICIAPADAQTEGVVFGYKGKNGPNQWGHLNPHFTTCAVGKLQSPIDIQRrqiFYNHKLNSIHREYYF 83
Cdd:COG3338   1 MKKRLLLALLLAAALPAAAAAAASAPHWSYEGETGPEHWGELSPEFATCATGKNQSPIDIRT---AIKADLPPLKFDYKP 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30693691  84 TNATLVN--HVCNVAMffgeGAGDVI-IENKNYTLLQMHWHTPSEHHLHGVQYAAELHMVHQAKDGSFAVVASLFKIGTE 160
Cdd:COG3338  78 TPLEIVNngHTIQVNV----DPGSTLtVDGKRYELKQFHFHTPSEHTINGKSYPMEAHLVHKDADGELAVVGVLFEEGAE 153

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 30693691 161 EPFLSQMKEKLVKLKEERLKGNHTaqvevgrIDTRHIERKTRKYYRYIGSLTTPPCSENVSWTIL 225
Cdd:COG3338 154 NPALAKLWANLPLEAGEEVALDAT-------IDLNDLLPEDRSYYRYSGSLTTPPCSEGVLWIVL 211
Carb_anhydrase smart01057
Eukaryotic-type carbonic anhydrase; Carbonic anhydrases are zinc metalloenzymes which catalyse ...
 31-229 5.99e-55

Eukaryotic-type carbonic anhydrase; Carbonic anhydrases are zinc metalloenzymes which catalyse the reversible hydration of carbon dioxide to bicarbonate.. CAs have essential roles in facilitating the transport of carbon dioxide and protons in the intracellular space, across biological membranes and in the layers of the extracellular space; they are also involved in many other processes, from respiration and photosynthesis in eukaryotes to cyanate degradation in prokaryotes. There are five known evolutionarily distinct CA families (alpha, beta, gamma, delta and epsilon) that have no significant sequence identity and have structurally distinct overall folds. Some CAs are membrane-bound, while others act in the cytosol; there are several related proteins that lack enzymatic activity. The active site of alpha-CAs is well described, consisting of a zinc ion coordinated through 3 histidine residues and a water molecule/hydroxide ion that acts as a potent nucleophile. The enzyme employs a two-step mechanism: in the first step, there is a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide; in the second step, the active site is regenerated by the ionisation of the zinc-bound water molecule and the removal of a proton from the active site. Beta- and gamma-CAs also employ a zinc hydroxide mechanism, although at least some beta-class enzymes do not have water directly coordinated to the metal ion.


Pssm-ID: 215000 [Multi-domain]  Cd Length: 247  Bit Score: 175.97  E-value: 5.99e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30693691     31 FGYKGKNGPNQWGHLNPHfttCAVGKLQSPIDIQRRQIFYNHKLNSIHREYYF-TNATLVNHVCNVAMFFGEGagDVIIE 109
Cdd:smart01057   1 WGYEGKNGPEHWGKLDPP---FCGGKRQSPIDIVTAEAQYDPSLKPLKLSYDQpTAKRILNNGHTVQVNFDDD--GSTLS 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30693691    110 NKN----YTLLQMHWHTP------SEHHLHGVQYAAELHMVHQAKDGSF----------AVVASLFKIGTEEPFLSQmke 169
Cdd:smart01057  76 GGPlpgrYRLKQFHFHWGgsdsegSEHTIDGKRFPLELHLVHYNSKGSFseavskpgglAVVAVFFKVGAEENPALQ--- 152

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 30693691    170 KLV-KLKEERLKGNhtaQVEVGRIDTRH-IERKTRKYYRYIGSLTTPPCSENVSWTILGKVI 229
Cdd:smart01057 153 AILdHLPLIKYKGQ---ETELTPFDLSSlLPASTRHYYTYNGSLTTPPCSEGVTWIVFKEPI 211
Carb_anhydrase pfam00194
Eukaryotic-type carbonic anhydrase;
37-229 9.51e-39

Eukaryotic-type carbonic anhydrase;


Pssm-ID: 459707 [Multi-domain]  Cd Length: 252  Bit Score: 134.32  E-value: 9.51e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30693691    37 NGPNQWGHlnpHFTTCAvGKLQSPIDIQRRQIFYNHKLNSIHREYY---FTNATLVN--HVCNVAMffgEGAGDVIIE-- 109
Cdd:pfam00194   1 LGPEHWGK---VYPSCG-GKRQSPINIDTRKVRYDPSLPPLTFQGYdvpPGKNTLTNngHTVQVSL---DDGDPSTISgg 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30693691   110 --NKNYTLLQMHWH------TPSEHHLHGVQYAAELHMVHQAKD-GSF----------AVVASLFKIGTEE-PFLsqmkE 169
Cdd:pfam00194  74 plATRYRLVQFHFHwgstdsRGSEHTIDGKRYPAELHIVHYNSKyKSFdeaakhpdglAVLGVFFEVGDENnPYL----Q 149

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 30693691   170 KLVKLKEERLKGNHTAQVEVGRIDTRhIERKTRKYYRYIGSLTTPPCSENVSWTILGKVI 229
Cdd:pfam00194 150 PIVSALDNIKYKGKSVLLPPFDLSDL-LPEDLTSYYTYNGSLTTPPCSESVTWIVFKEPI 208
 
Name Accession Description Interval E-value
PLN02202 PLN02202
carbonate dehydratase
 1-228 2.68e-170

carbonate dehydratase


Pssm-ID: 177853 [Multi-domain]  Cd Length: 284  Bit Score: 469.92  E-value: 2.68e-170
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30693691    1 MKIMMMIKLCFFSMSLICIAPADAQTEGVVFGYKGKNGPNQWGHLNPHFTTCAVGKLQSPIDIQRRQIFYNHKLNSIHRE 80
Cdd:PLN02202   1 MKIMMMIKLCFFAIALICIAPADAQTEGVVFGYKGKNGPNQWGHLNPHFTKCAVGKLQSPIDIQRRQIFYNHKLESIHRD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30693691   81 YYFTNATLVNHVCNVAMFFGEGAGDVIIENKNYTLLQMHWHTPSEHHLHGVQYAAELHMVHQAKDGSFAVVASLFKIGTE 160
Cdd:PLN02202  81 YYFTNATLVNHVCNVAMFFGEGAGDVIIDNKNYTLLQMHWHTPSEHHLHGVQYAAELHMVHQAKDGSFAVVASLFKIGTE 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 30693691  161 EPFLSQMKEKLVKLKEERLKGNHTAQVEVGRIDTRHIERKTRKYYRYIGSLTTPPCSENVSWTILGKV 228
Cdd:PLN02202 161 EPFLSQMKDKLVKLKEERFKGNHTAQVEVGKIDTRHIERKTRKYFRYIGSLTTPPCSENVSWTILGKV 228
alpha_CA_prokaryotic_like cd03124
Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are ...
 38-229 1.72e-77

Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidines. This sub-family includes bacterial carbonic anhydrase alpha, as well as plant enzymes such as tobacco nectarin III and yam dioscorin and, carbonic anhydrases from molluscs, such as nacrein, which are part of the organic matrix layer in shells. Other members of this family may be involved in maintaining pH balance, in facilitating transport of carbon dioxide or carbonic acid, or in sensing carbon dioxide levels in the environment. Dioscorin is the major storage protein of yam tubers and may play a role as an antioxidant. Tobacco Nectarin may play a role in the maintenace of pH and oxidative balance in nectar. Mollusc nacrein may participate in calcium carbonate crystal formation of the nacreous layer. This subfamily also includes three alpha carbonic anhydrases from Chlamydomonas reinhardtii (CAH 1-3). CAHs1-2 are localized in the periplasmic space. CAH1 faciliates the movement of carbon dioxide across the plasma membrane when the medium is alkaline. CAH3 is localized to the thylakoid lumen and provides CO2 to Rubisco.


Pssm-ID: 239398 [Multi-domain]  Cd Length: 216  Bit Score: 232.16  E-value: 1.72e-77
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30693691  38 GPNQWGHLNPHFTTCAVGKLQSPIDIQRRQIFYNHkLNSIHREYYFTNATLVNHVCNVAMFFGEGAGDVIIENKNYTLLQ 117
Cdd:cd03124   1 GPEHWGNLDPEFALCATGKNQSPIDITTKAVVSDK-LPPLNYNYKPTSATLVNNGHTIQVNFEGNGGTLTIDGETYQLLQ 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30693691 118 MHWHTPSEHHLHGVQYAAELHMVHQAKDGSFAVVASLFKIGTEEPFLSQMKEKLVKLKEErlkgnhTAQVEVGrIDTRHI 197
Cdd:cd03124  80 FHFHSPSEHLINGKRYPLEAHLVHKSKDGQLAVVAVLFEEGKENPFLKKILDNMPKKEGT------EVNLPAI-LDPNEL 152

                       170       180       190
                ....*....|....*....|....*....|..
gi 30693691 198 ERKTRKYYRYIGSLTTPPCSENVSWTILGKVI 229
Cdd:cd03124 153 LPESRSYYRYEGSLTTPPCSEGVRWIVLKQPI 184
Cah COG3338
Carbonic anhydrase [Inorganic ion transport and metabolism];
4-225 4.63e-61

Carbonic anhydrase [Inorganic ion transport and metabolism];


Pssm-ID: 442567 [Multi-domain]  Cd Length: 247  Bit Score: 191.64  E-value: 4.63e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30693691   4 MMMIKLCFFSMSLICIAPADAQTEGVVFGYKGKNGPNQWGHLNPHFTTCAVGKLQSPIDIQRrqiFYNHKLNSIHREYYF 83
Cdd:COG3338   1 MKKRLLLALLLAAALPAAAAAAASAPHWSYEGETGPEHWGELSPEFATCATGKNQSPIDIRT---AIKADLPPLKFDYKP 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30693691  84 TNATLVN--HVCNVAMffgeGAGDVI-IENKNYTLLQMHWHTPSEHHLHGVQYAAELHMVHQAKDGSFAVVASLFKIGTE 160
Cdd:COG3338  78 TPLEIVNngHTIQVNV----DPGSTLtVDGKRYELKQFHFHTPSEHTINGKSYPMEAHLVHKDADGELAVVGVLFEEGAE 153

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 30693691 161 EPFLSQMKEKLVKLKEERLKGNHTaqvevgrIDTRHIERKTRKYYRYIGSLTTPPCSENVSWTIL 225
Cdd:COG3338 154 NPALAKLWANLPLEAGEEVALDAT-------IDLNDLLPEDRSYYRYSGSLTTPPCSEGVLWIVL 211
Carb_anhydrase smart01057
Eukaryotic-type carbonic anhydrase; Carbonic anhydrases are zinc metalloenzymes which catalyse ...
 31-229 5.99e-55

Eukaryotic-type carbonic anhydrase; Carbonic anhydrases are zinc metalloenzymes which catalyse the reversible hydration of carbon dioxide to bicarbonate.. CAs have essential roles in facilitating the transport of carbon dioxide and protons in the intracellular space, across biological membranes and in the layers of the extracellular space; they are also involved in many other processes, from respiration and photosynthesis in eukaryotes to cyanate degradation in prokaryotes. There are five known evolutionarily distinct CA families (alpha, beta, gamma, delta and epsilon) that have no significant sequence identity and have structurally distinct overall folds. Some CAs are membrane-bound, while others act in the cytosol; there are several related proteins that lack enzymatic activity. The active site of alpha-CAs is well described, consisting of a zinc ion coordinated through 3 histidine residues and a water molecule/hydroxide ion that acts as a potent nucleophile. The enzyme employs a two-step mechanism: in the first step, there is a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide; in the second step, the active site is regenerated by the ionisation of the zinc-bound water molecule and the removal of a proton from the active site. Beta- and gamma-CAs also employ a zinc hydroxide mechanism, although at least some beta-class enzymes do not have water directly coordinated to the metal ion.


Pssm-ID: 215000 [Multi-domain]  Cd Length: 247  Bit Score: 175.97  E-value: 5.99e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30693691     31 FGYKGKNGPNQWGHLNPHfttCAVGKLQSPIDIQRRQIFYNHKLNSIHREYYF-TNATLVNHVCNVAMFFGEGagDVIIE 109
Cdd:smart01057   1 WGYEGKNGPEHWGKLDPP---FCGGKRQSPIDIVTAEAQYDPSLKPLKLSYDQpTAKRILNNGHTVQVNFDDD--GSTLS 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30693691    110 NKN----YTLLQMHWHTP------SEHHLHGVQYAAELHMVHQAKDGSF----------AVVASLFKIGTEEPFLSQmke 169
Cdd:smart01057  76 GGPlpgrYRLKQFHFHWGgsdsegSEHTIDGKRFPLELHLVHYNSKGSFseavskpgglAVVAVFFKVGAEENPALQ--- 152

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 30693691    170 KLV-KLKEERLKGNhtaQVEVGRIDTRH-IERKTRKYYRYIGSLTTPPCSENVSWTILGKVI 229
Cdd:smart01057 153 AILdHLPLIKYKGQ---ETELTPFDLSSlLPASTRHYYTYNGSLTTPPCSEGVTWIVFKEPI 211
PLN02179 PLN02179
carbonic anhydrase
 2-230 6.75e-52

carbonic anhydrase


Pssm-ID: 177835  Cd Length: 235  Bit Score: 167.85  E-value: 6.75e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30693691    2 KIMMMIKLCFFSMSLICIAPADAQTEG--VVFGYKGKN--GPNQWGHLNPHFTTCAVGKLQSPIDIQRRQIFYNHKlNSI 77
Cdd:PLN02179   6 KTIFFFVVFFIDLFFPNILLVYAREIGnkPLFTYKQKTekGPAEWGKLNPQWKVCSTGKYQSPIDLTDERVSLIHD-QAL 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30693691   78 HREYYFTNATLVNHVCNVAMFFGEGAGDVIIENKNYTLLQMHWHTPSEHHLHGVQYAAELHMVHQAKDGSFAVVASLFKI 157
Cdd:PLN02179  85 SRHYKPAPAVIQSRGHDVMVSWKGDAGKITIHQTDYKLVQCHWHSPSEHTINGTSYDLELHMVHTSASGKTAVVGVLYKL 164

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 30693691  158 GTEEPFLSQMKEKlvklkeerLKGNHTAQVEVGRIDTRHIERKTRKYYRYIGSLTTPPCSENVSWTILGKVIF 230
Cdd:PLN02179 165 GEPDEFLTKLLNG--------IKGVGKKEINLGIVDPRDIRFETNNFYRYIGSLTIPPCTEGVIWTVVKRVVW 229
alpha_CA cd00326
Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are ...
 55-229 2.08e-50

Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionary distinct groups - alpha, beta and gamma carbonic anhydrases - which show no significant sequence identity or structural similarity. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidine residues and a fourth conserved histidine plays a potential role in proton transfer.


Pssm-ID: 238200  Cd Length: 227  Bit Score: 163.61  E-value: 2.08e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30693691  55 GKLQSPIDIQRRQIFYNHKLNSIHREYY-FTNATLVNHVCNVAMFFGEGAGDVIIEN--KNYTLLQMHWHT------PSE 125
Cdd:cd00326   1 GKRQSPINIVTSAVVYDPSLPPLNFDYYpTTSLTLVNNGHTVQVNFDDDGGTLSGGGlpGRYKLVQFHFHWgsenspGSE 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30693691 126 HHLHGVQYAAELHMVHQ----------AKDGSFAVVASLFKIGTEE-PFLSQMKEKLvklkeeRLKGNHTAQVEVGRIDT 194
Cdd:cd00326  81 HTIDGKRYPLELHLVHYnsdyysseaaKKPGGLAVLGVFFEVGEKEnPFLKKILDAL------PKIKYKGKETTLPPFDL 154

                       170       180       190
                ....*....|....*....|....*....|....*.
gi 30693691 195 RH-IERKTRKYYRYIGSLTTPPCSENVSWTILGKVI 229
Cdd:cd00326 155 SDlLPSSLRDYYTYEGSLTTPPCSEGVTWIVFKEPI 190
Carb_anhydrase pfam00194
Eukaryotic-type carbonic anhydrase;
37-229 9.51e-39

Eukaryotic-type carbonic anhydrase;


Pssm-ID: 459707 [Multi-domain]  Cd Length: 252  Bit Score: 134.32  E-value: 9.51e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30693691    37 NGPNQWGHlnpHFTTCAvGKLQSPIDIQRRQIFYNHKLNSIHREYY---FTNATLVN--HVCNVAMffgEGAGDVIIE-- 109
Cdd:pfam00194   1 LGPEHWGK---VYPSCG-GKRQSPINIDTRKVRYDPSLPPLTFQGYdvpPGKNTLTNngHTVQVSL---DDGDPSTISgg 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30693691   110 --NKNYTLLQMHWH------TPSEHHLHGVQYAAELHMVHQAKD-GSF----------AVVASLFKIGTEE-PFLsqmkE 169
Cdd:pfam00194  74 plATRYRLVQFHFHwgstdsRGSEHTIDGKRYPAELHIVHYNSKyKSFdeaakhpdglAVLGVFFEVGDENnPYL----Q 149

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 30693691   170 KLVKLKEERLKGNHTAQVEVGRIDTRhIERKTRKYYRYIGSLTTPPCSENVSWTILGKVI 229
Cdd:pfam00194 150 PIVSALDNIKYKGKSVLLPPFDLSDL-LPEDLTSYYTYNGSLTTPPCSESVTWIVFKEPI 208
alpha_CA_VI_IX_XII_XIV cd03123
Carbonic anhydrase alpha, isozymes VI, IX, XII and XIV. Carbonic anhydrases (CAs) are ...
 38-225 1.18e-31

Carbonic anhydrase alpha, isozymes VI, IX, XII and XIV. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionary distinct groups - alpha, beta and gamma carbonic anhydrases - which show no significant sequence identity or structural similarity. Alpha CAs are mostly monomeric enzymes. The zinc ion is complexed by three histidine residues. This sub-family comprises the secreted CA VI, which is found in saliva, for example, and the membrane proteins CA IX, XII, and XIV.


Pssm-ID: 239397 [Multi-domain]  Cd Length: 248  Bit Score: 115.87  E-value: 1.18e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30693691  38 GPNQWGHlnpHFTTCAvGKLQSPIDIQRRQIFYNHKLNSIHREYYFTNA----TLVNHVCNV------AMFFGEGAGDVi 107
Cdd:cd03123   1 GEDHWPK---KYPACG-GKRQSPIDIQTDIVQFDPSLPPLELVGYDLPGteefTLTNNGHTVqlslppTMHIRGGPGTE- 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30693691 108 ienknYTLLQMHWH------TP-SEHHLHGVQYAAELHMVH----------QAKD--GSFAVVASLFKIG-TEEPFLSQM 167
Cdd:cd03123  76 -----YTAAQLHLHwggrgsLSgSEHTIDGIRFAAELHIVHynsdkyssfdEAADkpDGLAVLAILIEVGyPENTYYEKI 150

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 30693691 168 kekLVKLKEERLKGNHTaqvEVGRIDTRH-IERKTRKYYRYIGSLTTPPCSENVSWTIL 225
Cdd:cd03123 151 ---ISHLHEIKYKGQET---TVPGFNVRElLPEDLSHYYRYEGSLTTPPCYESVLWTVF 203
alpha_CA_I_II_III_XIII cd03119
Carbonic anhydrase alpha, isozymes I, II, and III and XIII. Carbonic anhydrases (CAs) are ...
 30-225 1.20e-29

Carbonic anhydrase alpha, isozymes I, II, and III and XIII. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidines. This vertebrate subgroup comprises isozymes I, II, and III, which are cytoplasmic enzymes. CA I, for example, is expressed in erythrocyes of many vertebrates; CA II is the most active cytosolic isozyme; while it is being expressed nearly ubiquitously, it comprises 95% of the renal carbonic anhydrase and is required for renal acidification; CA III has been implicated in protection from the damaging effect of oxidizing agents in hepatocytes. CAXIII may play important physiological roles in several organs.


Pssm-ID: 239393 [Multi-domain]  Cd Length: 259  Bit Score: 110.99  E-value: 1.20e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30693691  30 VFGYKGKNGPNQWGHLNPhfttCAVGKLQSPIDIQRRQIFYNHKLNSIHREYYFTNA-TLVN--HVCNVAmfFGEGAGDV 106
Cdd:cd03119   4 HWGYDSHNGPEHWHELFP----IAKGDRQSPIDIKTKDAKHDPSLKPLSVSYDPATAkTILNngHSFNVE--FDDTDDRS 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30693691 107 IIE----NKNYTLLQMHWH------TPSEHHLHGVQYAAELHMVH-QAKDGSF----------AVVASLFKIGTEEPFLS 165
Cdd:cd03119  78 VLRggplTGSYRLRQFHFHwgssddHGSEHTVDGVKYAAELHLVHwNSKYGSFgeaakqpdglAVVGVFLKVGEANPELQ 157

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 30693691 166 QMKEKLVKLKEerlKGNhtaQVEVGRIDTRHIERKTRKYYRYIGSLTTPPCSENVSWTIL 225
Cdd:cd03119 158 KVLDALDSIKT---KGK---QAPFTNFDPSCLLPASLDYWTYPGSLTTPPLLECVTWIVL 211
alpha_CA_VI cd03125
Carbonic anhydrase alpha, isozyme VI. Carbonic anhydrases (CAs) are zinc-containing enzymes ...
 41-225 2.31e-28

Carbonic anhydrase alpha, isozyme VI. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionary distinct groups - alpha, beta and gamma carbonic anhydrases - which show no significant sequence identity or structural similarity. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidine residues. This sub-family comprises the secreted CA VI, which is found in saliva.


Pssm-ID: 239399  Cd Length: 249  Bit Score: 107.56  E-value: 2.31e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30693691  41 QWGHlnpHFTTCAvGKLQSPIDIQRRQIFYNHKLNSIHREYYFTNA---TLVNHVCNV------AMFFGEGAGDViienk 111
Cdd:cd03125   4 HWPE---KYPACG-GKRQSPIDIQRREVRFNPSLLQLELVGYEKEQgefTMTNNGHTVqidlppTMSITTGDGTV----- 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30693691 112 nYTLLQMHWH--------TPSEHHLHGVQYAAELHMVH---------QAKD--GSFAVVASLFKIG--TEEPFLSQMKEK 170
Cdd:cd03125  75 -YTAVQMHFHwggrdseiSGSEHTIDGMRYVAELHIVHynskyksyeEAKDkpDGLAVLAFLYKVGhyAENTYYSDFISK 153

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 30693691 171 LVKLkeeRLKGNHTaqvEVGRIDTRH-IERKTRKYYRYIGSLTTPPCSENVSWTIL 225
Cdd:cd03125 154 LAKI---KYAGQTT---TLTSLDVRDmLPENLHHYYTYQGSLTTPPCTENVLWFVF 203
alpha_CA_IV_XV_like cd03117
Carbonic anhydrase alpha, CA_IV, CA_XV, like isozymes. Carbonic anhydrases (CAs) are ...
 55-229 1.67e-22

Carbonic anhydrase alpha, CA_IV, CA_XV, like isozymes. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionary distinct groups - alpha, beta and gamma carbonic anhydrases - which show no significant sequence identity or structural similarity. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidine residues. This subgroup, restricted to animals, contains isozyme IV and similar proteins such as mouse CA XV. Isozymes IV is attached to membranes via a glycosylphosphatidylinositol (GPI) tail. In mammals, Isozyme IV plays crucial roles in kidney and lung function, amongst others. This subgroup also contains the dual domain CA from the giant clam, Tridacna gigas. T. gigas CA plays a role in the movement of inorganic carbon from the surrounding seawater to the symbiotic algae found in the clam's tissues. CA XV is expressed in several species but not in humans or chimps. Similar to isozyme CA IV, CA XV attaches to membranes via a GPI tail.


Pssm-ID: 239391  Cd Length: 234  Bit Score: 91.56  E-value: 1.67e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30693691  55 GKLQSPIDIQRRQIFYNHKLNSIHREYY---FTNATLVNHVCNVAMFFGEGA----GDVIIEnknYTLLQMHWH-----T 122
Cdd:cd03117   1 GKRQSPINIVTKKVQYDENLTPFTFTGYddtTTNWTITNNGHTVQVTLPDGAkisgGGLPGT---YKALQFHFHwgsngS 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30693691 123 P-SEHHLHGVQYAAELHMVH---------QAKDGS--FAVVASLFKIGTE-----EPFLSQMKEKLVKLKEERLKGNHTA 185
Cdd:cd03117  78 PgSEHTIDGERYPMELHIVHikesynsllEALKDSdgLAVLGFFIEEGEEentnfDPLISALSNIPQKGGSTNLTPFSLR 157

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....
gi 30693691 186 QVEVGridtrhiERKTrKYYRYIGSLTTPPCSENVSWTILGKVI 229
Cdd:cd03117 158 SLLPS-------VLLT-KYYRYNGSLTTPGCNEAVIWTVFEEPI 193
alpha_CA_IX cd03150
Carbonic anhydrase alpha, isozyme IX. Carbonic anhydrases (CAs) are zinc-containing enzymes ...
 38-229 1.59e-20

Carbonic anhydrase alpha, isozyme IX. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionary distinct groups - alpha, beta and gamma carbonic anhydrases - which show no significant sequence identity or structural similarity. Alpha CAs are strictly monomeric enzymes. The zinc ion is complexed by three histidine residues. This sub-family comprises the membrane protein CA IX. CA IX is functionally implicated in tumor growth and survival. CA IX is mainly present in solid tumors and its expression in normal tissues is limited to the mucosa of alimentary tract. CA IX is a transmembrane protein with two extracellular domains: carbonic anhydrase and, a proteoglycan-like segment mediating cell-cell adhesion. There is evidence for an involvement of the MAPK pathway in the regulation of CA9 expression.


Pssm-ID: 239403  Cd Length: 247  Bit Score: 86.55  E-value: 1.59e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30693691  38 GPNQWGHLNPHfttCAvGKLQSPIDIQRRQIFYNHKLNSIHREYY----FTNATLVNHVCNVAMFFGEGAGDVIIENKNY 113
Cdd:cd03150   1 GQPPWPSVSPA---CA-GRFQSPVDIRPHLVAFCPALRPLELLGFdlppSPSLRLLNNGHTVQLSLPSGLRMALGPGQEY 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30693691 114 TLLQMHWH-----TP-SEHHLHGVQYAAELHMVH-----------QAKDGSFAVVASLFKIGTEEPflSQMKEKLVKLKE 176
Cdd:cd03150  77 RALQLHLHwgaagRPgSEHTVDGHRFPAEIHVVHlstafanldeaLGRPGGLAVLAAFLAEGLHEN--SAYEQLLSRLSE 154

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....
gi 30693691 177 ERLKGNHTaqvEVGRIDTRHI-ERKTRKYYRYIGSLTTPPCSENVSWTILGKVI 229
Cdd:cd03150 155 ISEEESET---VVPGLDVSALlPSDLSRYFRYEGSLTTPPCAQGVIWTVFNQTV 205
alpha_CA_VII cd03149
Carbonic anhydrase alpha, CA isozyme VII_like subgroup. Carbonic anhydrases (CAs) are ...
 55-229 1.72e-19

Carbonic anhydrase alpha, CA isozyme VII_like subgroup. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidines. This vertebrate subgroup comprises isozyme VII. CA VII is the most active cytosolic enzyme after CA II, and may be highly expressed in the brain. Human CA VII may be a target of antiepileptic sulfonamides/sulfamates.


Pssm-ID: 239402  Cd Length: 236  Bit Score: 83.73  E-value: 1.72e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30693691  55 GKLQSPIDIQRRQIFYNHKLNSIHREY-YFTNATLVNHVCNVAMFFGEGAGDVII-----ENKnYTLLQMHWH------T 122
Cdd:cd03149   1 GNRQSPIDIVSSEAVYDPKLKPLSLSYdPCTSLSISNNGHSVMVEFDDSDDKTVItggplENP-YRLKQFHFHwgakhgS 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30693691 123 PSEHHLHGVQYAAELHMVH-------------QAKDGsFAVVASLFKIGTEEPFLSQMKEKLVKLkeeRLKGnhtAQVEV 189
Cdd:cd03149  80 GSEHTVDGKTFPSELHLVHwnakkyksfgeaaAAPDG-LAVLGVFLETGDEHPGLNRLTDALYMV---RFKG---TKAQF 152

                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 30693691 190 GRIDTRHIERKTRKYYRYIGSLTTPPCSENVSWTILGKVI 229
Cdd:cd03149 153 LDFNPKCLLPKSLDYWTYPGSLTTPPLNESVTWIVLKEPI 192
alpha_CA_XII_XIV cd03126
Carbonic anhydrase alpha, isozymes XII and XIV. Carbonic anhydrases (CAs) are zinc-containing ...
 38-224 1.03e-18

Carbonic anhydrase alpha, isozymes XII and XIV. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionary distinct groups - alpha, beta and gamma carbonic anhydrases - which show no significant sequence identity or structural similarity. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidine residues. This sub-family comprises the membrane proteins CA XII and XIV.


Pssm-ID: 239400  Cd Length: 249  Bit Score: 81.81  E-value: 1.03e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30693691  38 GPNQWGHLNPhftTCAvGKLQSPIDIQRRQIFYNHKLNSIHREYYFTNAT----LVNHVCNVAMFFgegAGDVIIEN--K 111
Cdd:cd03126   1 GENSWPKKYP---FCG-GVAQSPIDIHTDILQYDSSLPPLEFHGYNVSGTeqftLTNNGHTVQLSL---PPTMHIGGlpF 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30693691 112 NYTLLQMHWH-----TP--SEHHLHGVQYAAELHMVHQAKDG------------SFAVVASLFKIGTEEPFLSQMkekLV 172
Cdd:cd03126  74 KYTASQLHLHwgqrgSPegSEHTISGKHFAAELHIVHYNSDKypdistamnksqGLAVLGILIEVGPFNPSYEKI---FS 150

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|...
gi 30693691 173 KLKEERLKGNhtaQVEVGRIDTRHI-ERKTRKYYRYIGSLTTPPCSENVSWTI 224
Cdd:cd03126 151 HLHEVKYKDQ---KVSVPGFNVQELlPKRLDEYYRYEGSLTTPPCYPSVLWTV 200
alpha_CA_V cd03118
Carbonic anhydrase alpha, CA isozyme V_like subgroup. Carbonic anhydrases (CAs) are ...
 55-229 9.75e-18

Carbonic anhydrase alpha, CA isozyme V_like subgroup. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidines. This vertebrate subgroup comprises isozyme V. CA V is the mitochondrial isozyme, which may play a role in gluconeogenesis and ureagenesis and possibly also in lipogenesis.


Pssm-ID: 239392  Cd Length: 236  Bit Score: 78.73  E-value: 9.75e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30693691  55 GKLQSPIDIQRRQIFYNHKLNSIHREYyftNATLVNHVCNVAMFF----GEGAGDVII-----ENKnYTLLQMHWH---- 121
Cdd:cd03118   1 GTRQSPINIQWRDSVYDPQLAPLRVSY---DPATCLYIWNNGYSFqvefDDSTDKSGIsggplENH-YRLKQFHFHwgan 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30693691 122 --TPSEHHLHGVQYAAELHMVHQAKD------------GSFAVVASLFKIGTEEPFLsqmkEKLVK-LKEERLKgnhTAQ 186
Cdd:cd03118  77 neWGSEHTVDGHTYPAELHLVHWNSVkyenfeeavmeeNGLAVIGVFLKLGAHHEGL----QKLVDaLPEVRHK---DTV 149

                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 30693691 187 VEVGRIDTRHIERKTRKYYRYIGSLTTPPCSENVSWTILGKVI 229
Cdd:cd03118 150 VEFNPFDPSCLLPACRDYWTYPGSLTTPPLTESVTWIIQKQPI 192
alpha_CARP_X_XI_like cd03121
Carbonic anhydrase alpha related protein: groups X, XI and related proteins. This subgroup ...
 38-230 1.05e-17

Carbonic anhydrase alpha related protein: groups X, XI and related proteins. This subgroup contains carbonic anhydrase related proteins (CARPs) X and XI, which have been implicated in various biological processes of the central nervous system. CARPs are sequence similar to carbonic anhydrases. Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism. CARPs have lost conserved histidines involved in zinc binding and consequently their catalytic activity. CARP XI plays a role in the development of gastrointestinal stromal tumors.


Pssm-ID: 239395 [Multi-domain]  Cd Length: 256  Bit Score: 78.99  E-value: 1.05e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30693691  38 GPNQWGHLNPHFTTCAVGKLQSPIDIQRRQIFYNHKLNSIHREYYF-TNATLVN---HVcnvaMFFGEGAGDVIIENK-- 111
Cdd:cd03121   1 GPSFWGLVNSAWNLCSKGRRQSPVDIEPSRLLFDPFLTPLRIDTGRkVSGTFYNtgrHV----SFRPDKDPVVNISGGpl 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30693691 112 --NYTLLQMHWH------TPSEHHLHGVQYAAELHMVHQAKD--GSFA---------VVASLF-KIG-TEEPFLSQMkek 170
Cdd:cd03121  77 syRYRLEEIRLHfgredeQGSEHTVNGQAFPGEVQLIHYNSElyPNFSeaskspnglVIVSLFvKIGeTSNPELRRL--- 153

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 30693691 171 LVKLKEERLK-GNHTAQVEVGRIDTRHIErkTRKYYRYIGSLTTPPCSENVSWTILGKVIF 230
Cdd:cd03121 154 TNRDTITSIRyKGDAYFLQDLSIELLLPE--TDHYITYEGSLTSPGCHETVTWIILNKPIY 212
alpha_CARP_receptor_like cd03122
Carbonic anhydrase alpha related protein, receptor_like subfamily. Carbonic anhydrase related ...
 38-224 3.15e-16

Carbonic anhydrase alpha related protein, receptor_like subfamily. Carbonic anhydrase related proteins (CARPs) are sequence similar to carbonic anhydrases. Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism. CARPs have lost conserved histidines involved in zinc binding and consequently their catalytic activity. This sub-family of carbonic anhydrase-related domains found in tyrosine phosphatase receptors may play a role in cell adhesion.


Pssm-ID: 239396 [Multi-domain]  Cd Length: 253  Bit Score: 75.08  E-value: 3.15e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30693691  38 GPNQWGHLNPHfttCAVGKLQSPIDIQR-RQIFYNHKLNSIHREYY-FTNATLV----NHV-----CNVAMFFGEGAGDV 106
Cdd:cd03122   1 NPKHWAKKYPA---CGEGRQQSPIDIVEdTQVQRQGLQPLHFDGYEeLTASTTLentgKTVilrleGNSSDPFVSGGPLL 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30693691 107 iienKNYTLLQMHWH------TPSEHHLHGVQYAAELHMVHQAKD-----------GSFAVVASLFKIGTEE-PFLSQMK 168
Cdd:cd03122  78 ----GRYKFSEITFHwgtcnsDGSEHSIDGHKFPLEMQILHRNTDffdsfeaikspGGVLALAYLFELSHEDnPFLDPII 153

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 30693691 169 E--KLVKLKEErlkgnhtaQVEVGRIDTRHI-ERKTRKYYRYIGSLTTPPCSENVSWTI 224
Cdd:cd03122 154 EglRNVSRPGK--------EVELPPFPLSDLlPPFTDKYYSYEGSLTTPPCSETVEWIV 204
alpha_CARP_VIII cd03120
Carbonic anhydrase alpha related protein, group VIII. Carbonic anhydrase related proteins ...
 41-225 4.47e-10

Carbonic anhydrase alpha related protein, group VIII. Carbonic anhydrase related proteins (CARPs) are sequence similar to carbonic anhydrases. Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism. CARPs have lost conserved histidines involved in zinc binding and consequently their catalytic activity. CARP VIII may play roles in various biological processes of the central nervous system, and could be involved in protein-protein interactions. CARP VIII has been shown to bind inositol 1,4,5-triphosphate (IP3) receptor type I (IP3RI), reducing the affinity of the receptor for IP3. IP3RI is an intracellular IP3-gated Ca2+ channel located on intracellular Ca2+ stores. IP3RI converts IP3 signaling into Ca2+ signaling thereby participating in a variety of cell functions.


Pssm-ID: 239394  Cd Length: 256  Bit Score: 57.94  E-value: 4.47e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30693691  41 QWGHLNPHfttcAVGKLQSPIDIQRRQIFYNHKLNSIHREYYFT---NATLVNHVCNVAMFFGEGA---GDVIIENKNYT 114
Cdd:cd03120   3 EWGLLFPE----ANGEYQSPINLNSREARYDPSLLEVRLSPNYVvcrDCEVINDGHTIQIILKSKSvlsGGPLPQGHEFE 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30693691 115 L--LQMHW----HTPSEHHLHGVQYAAELHMVH------------QAKDGSFAVVASLFKIGTEEPFLSQMKEKLVKLKe 176
Cdd:cd03120  79 LaeVRFHWgrenQRGSEHTVNFKAFPMELHLIHwnstlyssleeaMGKPHGIAIIALFVQIGKEHVGLKAVTEILQDIQ- 157

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 30693691 177 erLKGNhTAQVEVGRIDTRHIERKTRKYYRYIGSLTTPPCSENVSWTIL 225
Cdd:cd03120 158 --YKGK-SKTIPCFNPNTLLPDPLLRDYWVYEGSLTTPPCSEGVTWILF 203
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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