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    Plekha5 pleckstrin homology domain containing A5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 246237, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Plekha5provided by RGD
    Official Full Name
    pleckstrin homology domain containing A5provided by RGD
    Primary source
    RGD:621175
    See related
    EnsemblRapid:ENSRNOG00000008747 AllianceGenome:RGD:621175
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    TRS1; Pepp2
    Summary
    Predicted to enable phosphatidylinositol phosphate binding activity. Predicted to act upstream of or within reproductive system development. Predicted to be located in nucleoplasm. Predicted to be active in cytosol; glutamatergic synapse; and postsynaptic density. Orthologous to human PLEKHA5 (pleckstrin homology domain containing A5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 141.5), Kidney (RPKM 85.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Plekha5 in Genome Data Viewer
    Location:
    4q44
    Exon count:
    38
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (175065011..175234672)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (173333891..173503546)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (174605462..174774692)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene capping actin protein of muscle Z-line subunit alpha 3 Neighboring gene uncharacterized LOC108350783 Neighboring gene uncharacterized LOC134486859 Neighboring gene uncharacterized LOC120102424 Neighboring gene uncharacterized LOC134486860 Neighboring gene AE binding protein 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cloning and characterization of temperature-related gene TRS1. Han XB, et al. Arch Androl, 2002 Jul-Aug. PMID 12137588
    2. Identification and characterization of splicing variants of PLEKHA5 (Plekha5) during brain development. Yamada K, et al. Gene, 2012 Jan 15. PMID 22037487
    3. Correlation profiling of brain sub-cellular proteomes reveals co-assembly of synaptic proteins and subcellular distribution. Pandya NJ, et al. Sci Rep, 2017 Sep 21. PMID 28935861, Free PMC Article
    4. Two novel human X-linked homeobox genes, hPEPP1 and hPEPP2, selectively expressed in the testis. Wayne CM, et al. Gene, 2002 Nov 13. PMID 12490318
    5. Sertoli cell androgen receptor DNA binding domain is essential for the completion of spermatogenesis. Lim P, et al. Endocrinology, 2009 Oct. PMID 19574395

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables phosphatidylinositol-3,5-bisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-3,5-bisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol-3-phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-3-phosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol-4-phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-4-phosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol-5-phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-5-phosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within reproductive system development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    pleckstrin homology domain-containing family A member 5
    Names
    phosphoinositol 3-phosphate-binding protein 2
    pleckstrin homology domain containing, family A member 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_139340.3 → NP_647556.1  pleckstrin homology domain-containing family A member 5

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A0A8I5ZYP4, E9PTG5
      Related
      ENSRNOP00000047573.4, ENSRNOT00000042291.8
      Conserved Domains (3) summary
      cd13248
      Location:165 → 268
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00169
      Location:171 → 267
      PH; PH domain
      pfam00397
      Location:59 → 88
      WW; WW domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      175065011..175234672
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008763358.3 → XP_008761580.1  pleckstrin homology domain-containing family A member 5 isoform X4

      UniProtKB/TrEMBL
      A0A8I5ZYP4
      Related
      ENSRNOP00000111067.1, ENSRNOT00000124707.1
      Conserved Domains (3) summary
      cd13248
      Location:165 → 268
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00169
      Location:171 → 267
      PH; PH domain
      pfam00397
      Location:59 → 88
      WW; WW domain

    2. XM_008763357.3 → XP_008761579.1  pleckstrin homology domain-containing family A member 5 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZYP4
      Related
      ENSRNOP00000011770.7, ENSRNOT00000011770.7
      Conserved Domains (3) summary
      cd13248
      Location:165 → 268
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00169
      Location:171 → 267
      PH; PH domain
      pfam00397
      Location:59 → 88
      WW; WW domain

    3. XM_063285534.1 → XP_063141604.1  pleckstrin homology domain-containing family A member 5 isoform X6

      UniProtKB/TrEMBL
      A0A8I5ZYP4

    4. XM_017592456.3 → XP_017447945.1  pleckstrin homology domain-containing family A member 5 isoform X16

      UniProtKB/TrEMBL
      D3ZSV9

    5. XM_017592457.3 → XP_017447946.1  pleckstrin homology domain-containing family A member 5 isoform X19

      UniProtKB/TrEMBL
      D3ZSV9

    6. XM_017592452.3 → XP_017447941.1  pleckstrin homology domain-containing family A member 5 isoform X7

      UniProtKB/TrEMBL
      A0A8I5ZYP4

    7. XM_017592453.3 → XP_017447942.1  pleckstrin homology domain-containing family A member 5 isoform X8

      UniProtKB/TrEMBL
      A0A8I5ZYP4

    8. XM_063285535.1 → XP_063141605.1  pleckstrin homology domain-containing family A member 5 isoform X9

      UniProtKB/TrEMBL
      A0A8I5ZYP4

    9. XM_017592449.3 → XP_017447938.1  pleckstrin homology domain-containing family A member 5 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZYP4

    10. XM_017592455.3 → XP_017447944.1  pleckstrin homology domain-containing family A member 5 isoform X10

      UniProtKB/TrEMBL
      D3ZSV9
      Related
      ENSRNOP00000078444.2, ENSRNOT00000103935.2

    11. XM_039107036.2 → XP_038962964.1  pleckstrin homology domain-containing family A member 5 isoform X15

      UniProtKB/TrEMBL
      D3ZSV9
      Conserved Domains (3) summary
      COG1196
      Location:623 → 852
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd13248
      Location:165 → 268
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00397
      Location:59 → 88
      WW; WW domain

    12. XM_063285542.1 → XP_063141612.1  pleckstrin homology domain-containing family A member 5 isoform X29

      UniProtKB/TrEMBL
      A0A8I5ZYP4

    13. XM_008763359.3 → XP_008761581.1  pleckstrin homology domain-containing family A member 5 isoform X20

      UniProtKB/TrEMBL
      A0A8I5ZYP4
      Conserved Domains (3) summary
      cd13248
      Location:165 → 268
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00169
      Location:171 → 267
      PH; PH domain
      pfam00397
      Location:59 → 88
      WW; WW domain

    14. XM_063285537.1 → XP_063141607.1  pleckstrin homology domain-containing family A member 5 isoform X14

      UniProtKB/TrEMBL
      A0A8I5ZYP4

    15. XM_063285541.1 → XP_063141611.1  pleckstrin homology domain-containing family A member 5 isoform X24

      UniProtKB/TrEMBL
      A0A8I5ZYP4

    16. XM_017592465.3 → XP_017447954.1  pleckstrin homology domain-containing family A member 5 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZYP4

    17. XM_063285540.1 → XP_063141610.1  pleckstrin homology domain-containing family A member 5 isoform X22

      UniProtKB/TrEMBL
      D3ZSV9

    18. XM_008763360.3 → XP_008761582.1  pleckstrin homology domain-containing family A member 5 isoform X25

      UniProtKB/TrEMBL
      A0A8I5ZYP4
      Conserved Domains (3) summary
      cd13248
      Location:165 → 268
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00169
      Location:171 → 267
      PH; PH domain
      pfam00397
      Location:59 → 88
      WW; WW domain

    19. XM_063285536.1 → XP_063141606.1  pleckstrin homology domain-containing family A member 5 isoform X11

      UniProtKB/TrEMBL
      A0A8I5ZYP4

    20. XM_063285544.1 → XP_063141614.1  pleckstrin homology domain-containing family A member 5 isoform X31

      UniProtKB/TrEMBL
      A0A8I5ZYP4

    21. XM_039107033.2 → XP_038962961.1  pleckstrin homology domain-containing family A member 5 isoform X12

      UniProtKB/TrEMBL
      D3ZSV9
      Conserved Domains (3) summary
      COG1196
      Location:617 → 858
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd13248
      Location:165 → 268
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00397
      Location:59 → 88
      WW; WW domain

    22. XM_039107037.2 → XP_038962965.1  pleckstrin homology domain-containing family A member 5 isoform X21

      UniProtKB/TrEMBL
      D3ZSV9
      Conserved Domains (3) summary
      COG1196
      Location:617 → 846
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd13248
      Location:165 → 268
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00397
      Location:59 → 88
      WW; WW domain

    23. XM_039107038.2 → XP_038962966.1  pleckstrin homology domain-containing family A member 5 isoform X23

      UniProtKB/TrEMBL
      A0A8I5ZYP4
      Conserved Domains (3) summary
      COG1196
      Location:650 → 821
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd13248
      Location:165 → 268
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00397
      Location:59 → 88
      WW; WW domain

    24. XM_063285539.1 → XP_063141609.1  pleckstrin homology domain-containing family A member 5 isoform X18

      UniProtKB/TrEMBL
      A0A8I5ZYP4

    25. XM_017592459.3 → XP_017447948.1  pleckstrin homology domain-containing family A member 5 isoform X27

      UniProtKB/TrEMBL
      D3ZSV9

    26. XM_039107039.2 → XP_038962967.1  pleckstrin homology domain-containing family A member 5 isoform X26

      UniProtKB/TrEMBL
      A0A8I5ZYP4
      Conserved Domains (3) summary
      COG1196
      Location:632 → 803
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd13248
      Location:165 → 268
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00397
      Location:59 → 88
      WW; WW domain

    27. XM_017592461.3 → XP_017447950.1  pleckstrin homology domain-containing family A member 5 isoform X41

    28. XM_063285548.1 → XP_063141618.1  pleckstrin homology domain-containing family A member 5 isoform X38

      UniProtKB/TrEMBL
      A0A8I5ZYP4
      Related
      ENSRNOP00000110325.1, ENSRNOT00000134221.1

    29. XM_063285546.1 → XP_063141616.1  pleckstrin homology domain-containing family A member 5 isoform X36

      UniProtKB/TrEMBL
      A0A8I5ZYP4

    30. XM_039107042.2 → XP_038962970.1  pleckstrin homology domain-containing family A member 5 isoform X34

      UniProtKB/TrEMBL
      A0A8I5ZYP4
      Conserved Domains (3) summary
      cd13248
      Location:165 → 268
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      TIGR02168
      Location:607 → 842
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam00397
      Location:59 → 88
      WW; WW domain

    31. XM_039107041.2 → XP_038962969.1  pleckstrin homology domain-containing family A member 5 isoform X33

      UniProtKB/TrEMBL
      A0A8I5ZYP4
      Conserved Domains (3) summary
      COG1196
      Location:650 → 818
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd13248
      Location:165 → 268
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00397
      Location:59 → 88
      WW; WW domain

    32. XM_063285545.1 → XP_063141615.1  pleckstrin homology domain-containing family A member 5 isoform X32

      UniProtKB/TrEMBL
      A0A8I5ZYP4

    33. XM_008763362.4 → XP_008761584.1  pleckstrin homology domain-containing family A member 5 isoform X35

      UniProtKB/TrEMBL
      A0A8I5ZKV5, A0A8I5ZYP4
      Related
      ENSRNOP00000095265.2, ENSRNOT00000103410.2
      Conserved Domains (3) summary
      cd13248
      Location:165 → 268
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00169
      Location:171 → 267
      PH; PH domain
      pfam00397
      Location:59 → 88
      WW; WW domain

    34. XM_063285547.1 → XP_063141617.1  pleckstrin homology domain-containing family A member 5 isoform X37

      UniProtKB/TrEMBL
      A0A8I5ZYP4

    35. XM_063285549.1 → XP_063141619.1  pleckstrin homology domain-containing family A member 5 isoform X39

      UniProtKB/TrEMBL
      A0A8I5ZYP4
      Related
      ENSRNOP00000084216.1, ENSRNOT00000095631.2

    36. XM_017592462.3 → XP_017447951.1  pleckstrin homology domain-containing family A member 5 isoform X42

    37. XM_039107040.2 → XP_038962968.1  pleckstrin homology domain-containing family A member 5 isoform X28

      UniProtKB/TrEMBL
      D3ZSV9
      Conserved Domains (2) summary
      COG1196
      Location:514 → 755
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd13248
      Location:56 → 159
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain

    38. XM_063285543.1 → XP_063141613.1  pleckstrin homology domain-containing family A member 5 isoform X30

      UniProtKB/TrEMBL
      D3ZSV9

    39. XM_063285538.1 → XP_063141608.1  pleckstrin homology domain-containing family A member 5 isoform X17

      UniProtKB/TrEMBL
      D3ZSV9

    40. XM_039107035.2 → XP_038962963.1  pleckstrin homology domain-containing family A member 5 isoform X13

      UniProtKB/TrEMBL
      D3ZSV9
      Conserved Domains (2) summary
      COG1196
      Location:554 → 795
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd13248
      Location:96 → 199
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain

    41. XM_039107034.2 → XP_038962962.1  pleckstrin homology domain-containing family A member 5 isoform X13

      UniProtKB/TrEMBL
      D3ZSV9
      Conserved Domains (2) summary
      COG1196
      Location:554 → 795
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd13248
      Location:96 → 199
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain

    42. XM_017592451.3 → XP_017447940.1  pleckstrin homology domain-containing family A member 5 isoform X5

      UniProtKB/TrEMBL
      D3ZSV9

    43. XM_008763361.4 → XP_008761583.1  pleckstrin homology domain-containing family A member 5 isoform X28

      UniProtKB/TrEMBL
      D3ZSV9
      Conserved Domains (2) summary
      COG1196
      Location:514 → 755
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd13248
      Location:56 → 159
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain

    44. XM_008763363.4 → XP_008761585.1  pleckstrin homology domain-containing family A member 5 isoform X40

      UniProtKB/TrEMBL
      D3ZSV9
      Conserved Domains (1) summary
      cl17171
      Location:11 → 40
      PH-like; Pleckstrin homology-like domain

    RNA

    1. XR_010065614.1 RNA Sequence

    2. XR_005503147.2 RNA Sequence

    3. XR_592304.3 RNA Sequence

    4. XR_001837479.3 RNA Sequence

    5. XR_010065613.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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