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    Egr3 early growth response 3 [ Mus musculus (house mouse) ]

    Gene ID: 13655, updated on 27-Nov-2024

    Summary

    Official Symbol
    Egr3provided by MGI
    Official Full Name
    early growth response 3provided by MGI
    Primary source
    MGI:MGI:1306780
    See related
    Ensembl:ENSMUSG00000033730 AllianceGenome:MGI:1306780
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    EGR-3; Pilot
    Summary
    Enables DNA-binding transcription activator activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within neuromuscular synaptic transmission; peripheral nervous system development; and regulation of T cell differentiation. Predicted to be located in nucleoplasm. Is expressed in several structures, including ganglionic eminence; genitourinary system; limb musculature; tooth; and vibrissa. Orthologous to human EGR3 (early growth response 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in cortex adult (RPKM 18.1), testis adult (RPKM 16.4) and 7 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Egr3 in Genome Data Viewer
    Location:
    14 D2; 14 36.2 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (70314766..70320062)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (70077317..70082613)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene phosphatidylethanolamine binding protein 4 Neighboring gene STARR-seq mESC enhancer starr_37071 Neighboring gene predicted gene, 41198 Neighboring gene predicted gene, 33524 Neighboring gene STARR-seq mESC enhancer starr_37072 Neighboring gene STARR-positive B cell enhancer mm9_chr14:70468715-70469016 Neighboring gene STARR-positive B cell enhancer mm9_chr14:70469146-70469446 Neighboring gene STARR-positive B cell enhancer ABC_E8569 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:70499772-70499955 Neighboring gene bridging integrator 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:70553578-70553761 Neighboring gene cell cycle activator and apoptosis regulator 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (6)  1 citation

    General gene information

    Markers

    Clone Names

    • MGC124006, MGC124009

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in cell migration involved in sprouting angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell migration involved in sprouting angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to fibroblast growth factor stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to fibroblast growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to vascular endothelial growth factor stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to vascular endothelial growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endothelial cell chemotaxis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in endothelial cell chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within neuromuscular synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within peripheral nervous system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of T cell differentiation in thymus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of endothelial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of endothelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within regulation of gamma-delta T cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    early growth response protein 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289925.2NP_001276854.1  early growth response protein 3 isoform 2

      See identical proteins and their annotated locations for NP_001276854.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate exon compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AC123867
      Consensus CDS
      CCDS88701.1
      UniProtKB/TrEMBL
      Q3ZB14, Q3ZB15
      Related
      ENSMUSP00000037042.3, ENSMUST00000035908.3
      Conserved Domains (3) summary
      COG5048
      Location:265337
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:239261
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam11928
      Location:49109
      DUF3446; Domain of unknown function (DUF3446)
    2. NM_001289927.1NP_001276856.1  early growth response protein 3 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate first exon compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AC123867, BY238697
      UniProtKB/TrEMBL
      Q3ZB15
      Conserved Domains (3) summary
      COG5048
      Location:249321
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:223245
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam11928
      Location:3393
      DUF3446; Domain of unknown function (DUF3446)
    3. NM_018781.4NP_061251.1  early growth response protein 3 isoform 1

      See identical proteins and their annotated locations for NP_061251.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC123867
      Consensus CDS
      CCDS27246.1
      UniProtKB/Swiss-Prot
      P43300, Q9R276
      UniProtKB/TrEMBL
      Q496R7
      Related
      ENSMUSP00000153491.2, ENSMUST00000225200.2
      Conserved Domains (3) summary
      COG5048
      Location:303375
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:277299
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam11928
      Location:87147
      DUF3446; Domain of unknown function (DUF3446)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      70314766..70320062
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)