NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|9055212|ref|NP_061251|]
View 

early growth response protein 3 isoform 1 [Mus musculus]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
DUF3446 pfam11928
Early growth response N-terminal domain; Proteins containing this domain include early growth ...
 87-173 7.25e-10

Early growth response N-terminal domain; Proteins containing this domain include early growth response protein 1/2/3 (EGR1/2/3). EGR1 is a transcriptional regulator that binds specifically to 9-bp target sequences containing two CpG sites that can potentially be methylated at four cytosine bases. EGR2, also known as Krox20, is an E3 ligase that sumoylates its Nab coregulators. This domain has a single completely conserved residue P that may be functionally important. Furthermore, it is found associated with pfam00096.


:

Pssm-ID: 463400  Cd Length: 104  Bit Score: 55.61  E-value: 7.25e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9055212     87 GKFAFDSP----SNWCQDNIISLMSaGILGV-PPASGALSTQTSTAS-----------MVQPPQGDVEAMYPALPPY--S 148
Cdd:pfam11928   1 GKFSIDPQypggGSLWPEGLISLVS-GLVGMaNPPSSSSSSSPSSSSspnssgplctmSCSVQSSEMEHIYSAPPPYpsS 79

                          90       100
                  ....*....|....*....|....*
gi 9055212    149 NCGDLYSEPVSFHDPQGNPGLAYSP 173
Cdd:pfam11928  80 GCGDLYQDPSAFLSTPSGPPLAYPP 104
zf-H2C2_2 pfam13465
Zinc-finger double domain;
319-344 1.45e-06

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 44.28  E-value: 1.45e-06
                          10        20
                  ....*....|....*....|....*.
gi 9055212    319 HLTTHIRTHTGEKPFACEFCGRKFAR 344
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
303-375 3.45e-06

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.92  E-value: 3.45e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 9055212  303 KPFQCRICMRSFSRSDHLTTHIRTHTGEKPFACEFCGRKFARSD--ERKRHAKIHLKQKEKKSEKGGAPSASSAP 375
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRplELSRHLRTHHNNPSDLNSKSLPLSNSKAS 106
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 275-299 1.53e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


:

Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.74  E-value: 1.53e-03
                          10        20
                  ....*....|....*....|....*
gi 9055212    275 HACPaeGCDRRFSRSDELTRHLRIH 299
Cdd:pfam00096   1 YKCP--DCGKSFSRKSNLKRHLRTH 23
 
Name Accession Description Interval E-value
DUF3446 pfam11928
Early growth response N-terminal domain; Proteins containing this domain include early growth ...
 87-173 7.25e-10

Early growth response N-terminal domain; Proteins containing this domain include early growth response protein 1/2/3 (EGR1/2/3). EGR1 is a transcriptional regulator that binds specifically to 9-bp target sequences containing two CpG sites that can potentially be methylated at four cytosine bases. EGR2, also known as Krox20, is an E3 ligase that sumoylates its Nab coregulators. This domain has a single completely conserved residue P that may be functionally important. Furthermore, it is found associated with pfam00096.


Pssm-ID: 463400  Cd Length: 104  Bit Score: 55.61  E-value: 7.25e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9055212     87 GKFAFDSP----SNWCQDNIISLMSaGILGV-PPASGALSTQTSTAS-----------MVQPPQGDVEAMYPALPPY--S 148
Cdd:pfam11928   1 GKFSIDPQypggGSLWPEGLISLVS-GLVGMaNPPSSSSSSSPSSSSspnssgplctmSCSVQSSEMEHIYSAPPPYpsS 79

                          90       100
                  ....*....|....*....|....*
gi 9055212    149 NCGDLYSEPVSFHDPQGNPGLAYSP 173
Cdd:pfam11928  80 GCGDLYQDPSAFLSTPSGPPLAYPP 104
zf-H2C2_2 pfam13465
Zinc-finger double domain;
319-344 1.45e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 44.28  E-value: 1.45e-06
                          10        20
                  ....*....|....*....|....*.
gi 9055212    319 HLTTHIRTHTGEKPFACEFCGRKFAR 344
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
303-375 3.45e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.92  E-value: 3.45e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 9055212  303 KPFQCRICMRSFSRSDHLTTHIRTHTGEKPFACEFCGRKFARSD--ERKRHAKIHLKQKEKKSEKGGAPSASSAP 375
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRplELSRHLRTHHNNPSDLNSKSLPLSNSKAS 106
zf-H2C2_2 pfam13465
Zinc-finger double domain;
291-316 7.30e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 42.36  E-value: 7.30e-06
                          10        20
                  ....*....|....*....|....*.
gi 9055212    291 ELTRHLRIHTGHKPFQCRICMRSFSR 316
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 275-299 1.53e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.74  E-value: 1.53e-03
                          10        20
                  ....*....|....*....|....*
gi 9055212    275 HACPaeGCDRRFSRSDELTRHLRIH 299
Cdd:pfam00096   1 YKCP--DCGKSFSRKSNLKRHLRTH 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
269-333 5.33e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 38.91  E-value: 5.33e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 9055212  269 PLHERPHACPaeGCDRRFSRSDELTRHLRIHTGHKPFQCRICMR--SFSRSDHLTTHIRTHTGEKPF 333
Cdd:COG5048  28 SNAPRPDSCP--NCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCdkSFSRPLELSRHLRTHHNNPSD 92
ZnF_C2H2 smart00355
zinc finger;
305-327 7.36e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 33.59  E-value: 7.36e-03
                           10        20
                   ....*....|....*....|...
gi 9055212     305 FQCRICMRSFSRSDHLTTHIRTH 327
Cdd:smart00355   1 YRCPECGKVFKSKSALREHMRTH 23
PHA00733 PHA00733
hypothetical protein
 304-351 9.98e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 36.01  E-value: 9.98e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 9055212   304 PFQCRICMRSFSRSDHLTTHIRTHTGEKpfACEFCGRKFARSDERKRH 351
Cdd:PHA00733  73 PYVCPLCLMPFSSSVSLKQHIRYTEHSK--VCPVCGKEFRNTDSTLDH 118
 
Name Accession Description Interval E-value
DUF3446 pfam11928
Early growth response N-terminal domain; Proteins containing this domain include early growth ...
 87-173 7.25e-10

Early growth response N-terminal domain; Proteins containing this domain include early growth response protein 1/2/3 (EGR1/2/3). EGR1 is a transcriptional regulator that binds specifically to 9-bp target sequences containing two CpG sites that can potentially be methylated at four cytosine bases. EGR2, also known as Krox20, is an E3 ligase that sumoylates its Nab coregulators. This domain has a single completely conserved residue P that may be functionally important. Furthermore, it is found associated with pfam00096.


Pssm-ID: 463400  Cd Length: 104  Bit Score: 55.61  E-value: 7.25e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9055212     87 GKFAFDSP----SNWCQDNIISLMSaGILGV-PPASGALSTQTSTAS-----------MVQPPQGDVEAMYPALPPY--S 148
Cdd:pfam11928   1 GKFSIDPQypggGSLWPEGLISLVS-GLVGMaNPPSSSSSSSPSSSSspnssgplctmSCSVQSSEMEHIYSAPPPYpsS 79

                          90       100
                  ....*....|....*....|....*
gi 9055212    149 NCGDLYSEPVSFHDPQGNPGLAYSP 173
Cdd:pfam11928  80 GCGDLYQDPSAFLSTPSGPPLAYPP 104
zf-H2C2_2 pfam13465
Zinc-finger double domain;
319-344 1.45e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 44.28  E-value: 1.45e-06
                          10        20
                  ....*....|....*....|....*.
gi 9055212    319 HLTTHIRTHTGEKPFACEFCGRKFAR 344
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
303-375 3.45e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.92  E-value: 3.45e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 9055212  303 KPFQCRICMRSFSRSDHLTTHIRTHTGEKPFACEFCGRKFARSD--ERKRHAKIHLKQKEKKSEKGGAPSASSAP 375
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRplELSRHLRTHHNNPSDLNSKSLPLSNSKAS 106
zf-H2C2_2 pfam13465
Zinc-finger double domain;
291-316 7.30e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 42.36  E-value: 7.30e-06
                          10        20
                  ....*....|....*....|....*.
gi 9055212    291 ELTRHLRIHTGHKPFQCRICMRSFSR 316
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 260-353 2.11e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 46.25  E-value: 2.11e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9055212  260 KYPNRPSKTpLHERPHACPAEGCDRRFSRSDELTRHlRIHtGHK-----PFQCRICMRSFSRSDhltthirthtgeKPFA 334
Cdd:COG5189 336 DTPSRMLKV-KDGKPYKCPVEGCNKKYKNQNGLKYH-MLH-GHQnqklhENPSPEKMNIFSAKD------------KPYR 400

                        90
                ....*....|....*....
gi 9055212  335 CEFCGRKFARSDERKRHAK 353
Cdd:COG5189 401 CEVCDKRYKNLNGLKYHRK 419
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 305-327 2.42e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 38.05  E-value: 2.42e-04
                          10        20
                  ....*....|....*....|...
gi 9055212    305 FQCRICMRSFSRSDHLTTHIRTH 327
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2_4 pfam13894
C2H2-type zinc finger; This family contains a number of divergent C2H2 type zinc fingers.
 305-327 1.41e-03

C2H2-type zinc finger; This family contains a number of divergent C2H2 type zinc fingers.


Pssm-ID: 464025  Cd Length: 24  Bit Score: 35.70  E-value: 1.41e-03
                          10        20
                  ....*....|....*....|...
gi 9055212    305 FQCRICMRSFSRSDHLTTHIRTH 327
Cdd:pfam13894   1 FKCPICGKSFSSKKSLKRHLKTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 275-299 1.53e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.74  E-value: 1.53e-03
                          10        20
                  ....*....|....*....|....*
gi 9055212    275 HACPaeGCDRRFSRSDELTRHLRIH 299
Cdd:pfam00096   1 YKCP--DCGKSFSRKSNLKRHLRTH 23
COG5236 COG5236
Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only];
277-356 2.08e-03

Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only];


Pssm-ID: 227561 [Multi-domain]  Cd Length: 493  Bit Score: 40.00  E-value: 2.08e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9055212  277 CPAEGCDRRFSRSDELTRHLRIHtgHKPFQCRICMR---------SFSRSDHLTTHIRTHTGEKPFA----CEFCGRKFA 343
Cdd:COG5236 154 CPKSKCHRRCGSLKELKKHYKAQ--HGFVLCSECIGnkkdfwneiRLFRSSTLRDHKNGGLEEEGFKghplCIFCKIYFY 231

                        90
                ....*....|....*...
gi 9055212  344 RSDE-----RKRHAKIHL 356
Cdd:COG5236 232 DDDElrrhcRLRHEACHI 249
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
269-333 5.33e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 38.91  E-value: 5.33e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 9055212  269 PLHERPHACPaeGCDRRFSRSDELTRHLRIHTGHKPFQCRICMR--SFSRSDHLTTHIRTHTGEKPF 333
Cdd:COG5048  28 SNAPRPDSCP--NCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCdkSFSRPLELSRHLRTHHNNPSD 92
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
282-373 5.86e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 38.52  E-value: 5.86e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9055212  282 CDRRFSRSDELTRHLR--IHTG--HKPFQCRI--CMRSFSRSDHLTTHIRTHTGEKPFAC--EFCGRKFARSDERKRHAK 353
Cdd:COG5048 295 CNISFSRSSPLTRHLRsvNHSGesLKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQS 374

                        90       100
                ....*....|....*....|
gi 9055212  354 IHLKQKEKKSEKGGAPSASS 373
Cdd:COG5048 375 LQQYKDLKNDKKSETLSNSC 394
ZnF_C2H2 smart00355
zinc finger;
305-327 7.36e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 33.59  E-value: 7.36e-03
                           10        20
                   ....*....|....*....|...
gi 9055212     305 FQCRICMRSFSRSDHLTTHIRTH 327
Cdd:smart00355   1 YRCPECGKVFKSKSALREHMRTH 23
PHA00733 PHA00733
hypothetical protein
 304-351 9.98e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 36.01  E-value: 9.98e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 9055212   304 PFQCRICMRSFSRSDHLTTHIRTHTGEKpfACEFCGRKFARSDERKRH 351
Cdd:PHA00733  73 PYVCPLCLMPFSSSVSLKQHIRYTEHSK--VCPVCGKEFRNTDSTLDH 118
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH