HIPP1 HP1 and insulator partner protein 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: HIPP1provided by FlyBase
Official Full Name: HP1 and insulator partner protein 1provided by FlyBase
Primary source: FLYBASE:FBgn0037027
Locus tag: Dmel_CG3680
See related: AllianceGenome:FB:FBgn0037027
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG3680; Dmel\CG3680; Hipp1; HiPP1
Summary: Enables chromatin insulator sequence binding activity and euchromatin binding activity. Located in nucleus. Is expressed in adult head. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 77E8-77E8; 3-47 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (20809669..20813332)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (20802769..20806432)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A Drosophila insulator interacting protein suppresses enhancer-blocking function and modulates replication timing.
Title: A Drosophila insulator interacting protein suppresses enhancer-blocking function and modulates replication timing.
HIPP1 stabilizes the interaction between CP190 and Su(Hw) in the Drosophila insulator complex.
Title: HIPP1 stabilizes the interaction between CP190 and Su(Hw) in the Drosophila insulator complex.
HIPP1 is dispensable for the transcriptional and insulator functions of Su(Hw), indicating that HIPP1 is not a critical Su(Hw) cofactor.
Title: Investigation of the Developmental Requirements of Drosophila HP1 and Insulator Protein Partner, HIPP1.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables chromatin insulator sequence binding	IDA Inferred from Direct Assay more info	PubMed
enables crotonyl-CoA hydratase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables euchromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: HP1 and insulator partner protein 1

Names: CG3680-PA; CG3680-PB; CG3680-PC; CG3680-PD; HIPP1-PA; HIPP1-PB; HIPP1-PC; HIPP1-PD; HP1 and insulator partner protein-1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

20809669..20813332

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_141004.3 → NP_649261.1 HP1 and insulator partner protein 1, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_649261.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9VPB0

Related

FBpp0077914

Conserved Domains (1) summary

cd06558
Location:673 → 870

crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...
NM_001275198.1 → NP_001262127.1 HP1 and insulator partner protein 1, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262127.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PG20

Conserved Domains (1) summary

cd06558
Location:673 → 869

crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...
NM_001275197.1 → NP_001262126.1 HP1 and insulator partner protein 1, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262126.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PG82

Conserved Domains (1) summary

cd06558
Location:671 → 868

crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...
NM_001275199.1 → NP_001262128.1 HP1 and insulator partner protein 1, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262128.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PID3

Conserved Domains (1) summary

cd06558
Location:671 → 867

crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...