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Conserved domains on  [gi|442633773|ref|NP_001262126|]
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HP1 and insulator partner protein 1, isoform B [Drosophila melanogaster]

Protein Classification

enoyl-CoA hydratase/isomerase family protein( domain architecture ID 10158671)

enoyl-CoA hydratase/isomerase family protein similar to enoyl-CoA hydratase, which catalyzes the second step in the beta-oxidation pathway of fatty acid metabolism, the syn-addition of a water molecule across the double bond of a trans-2-enoyl-CoA thioester, resulting in the formation of a beta-hydroxyacyl-CoA thioester

CATH:  1.10.12.10
Gene Ontology:  GO:0003824
PubMed:  18470480|11263873
SCOP:  4000036

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
crotonase-like cd06558
Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse ...
 671-868 8.15e-28

Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. Many of these play important roles in fatty acid metabolism. In addition to a conserved structural core and the formation of trimers (or dimers of trimers), a common feature in this superfamily is the stabilization of an enolate anion intermediate derived from an acyl-CoA substrate. This is accomplished by two conserved backbone NH groups in active sites that form an oxyanion hole.


:

Pssm-ID: 119339 [Multi-domain]  Cd Length: 195  Bit Score: 111.50  E-value: 8.15e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442633773 671 LHKVNKVAHLVIHteRGNFGHTYSKQLLEQLNDTLSSVARKGEFNTVLLTVEGPQFCQGIDCQELiqGSLEKRKDSASQL 750
Cdd:cd06558    3 VERDGGVATITLN--RPEKRNALSLEMLDELAAALDEAEADPDVRVVVLTGAGKAFCAGADLKEL--AALSDAGEEARAF 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442633773 751 AVALKCYLRTLATFPKPLVAGIVGSQINLGVMQLPFADYVVASDDCSFETNYAKLGQLPEGYALWHGHQRVSSEVHSRLF 830
Cdd:cd06558   79 IRELQELLRALLRLPKPVIAAVNGAALGGGLELALACDIRIAAEDAKFGLPEVKLGLVPGGGGTQRLPRLVGPARARELL 158

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 442633773 831 LMGERLFATELLESNsFVDKICKARNVNEMALAKAKQI 868
Cdd:cd06558  159 LTGRRISAEEALELG-LVDEVVPDEELLAAALELARRL 195
 
Name Accession Description Interval E-value
crotonase-like cd06558
Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse ...
 671-868 8.15e-28

Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. Many of these play important roles in fatty acid metabolism. In addition to a conserved structural core and the formation of trimers (or dimers of trimers), a common feature in this superfamily is the stabilization of an enolate anion intermediate derived from an acyl-CoA substrate. This is accomplished by two conserved backbone NH groups in active sites that form an oxyanion hole.


Pssm-ID: 119339 [Multi-domain]  Cd Length: 195  Bit Score: 111.50  E-value: 8.15e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442633773 671 LHKVNKVAHLVIHteRGNFGHTYSKQLLEQLNDTLSSVARKGEFNTVLLTVEGPQFCQGIDCQELiqGSLEKRKDSASQL 750
Cdd:cd06558    3 VERDGGVATITLN--RPEKRNALSLEMLDELAAALDEAEADPDVRVVVLTGAGKAFCAGADLKEL--AALSDAGEEARAF 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442633773 751 AVALKCYLRTLATFPKPLVAGIVGSQINLGVMQLPFADYVVASDDCSFETNYAKLGQLPEGYALWHGHQRVSSEVHSRLF 830
Cdd:cd06558   79 IRELQELLRALLRLPKPVIAAVNGAALGGGLELALACDIRIAAEDAKFGLPEVKLGLVPGGGGTQRLPRLVGPARARELL 158

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 442633773 831 LMGERLFATELLESNsFVDKICKARNVNEMALAKAKQI 868
Cdd:cd06558  159 LTGRRISAEEALELG-LVDEVVPDEELLAAALELARRL 195
CaiD COG1024
Enoyl-CoA hydratase/carnithine racemase [Lipid transport and metabolism]; Enoyl-CoA hydratase ...
 675-910 2.96e-17

Enoyl-CoA hydratase/carnithine racemase [Lipid transport and metabolism]; Enoyl-CoA hydratase/carnithine racemase is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440647 [Multi-domain]  Cd Length: 249  Bit Score: 82.52  E-value: 2.96e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442633773 675 NKVAHLVIHT-ERGNfghTYSKQLLEQLNDTLSSVARKGEFNTVLLTVEGPQFCQGIDCQELIQGSlekrkDSASQLAVA 753
Cdd:COG1024    7 GGVATITLNRpEKLN---ALSLEMLAELAAALDEAEADPDVRVVVLTGAGKAFCAGADLKELAAAA-----DPEEARAFA 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442633773 754 LKCY--LRTLATFPKPLVAGIVGSQINLGV-MQLpFADYVVASDDCSFETNYAKLGQLPEGYALWHGHQRVSSEVHSRLF 830
Cdd:COG1024   79 RGLQrlFRALRRLPKPVIAAVNGAALGGGLeLAL-ACDLRIAAEDARFGLPEVRLGLIPGGGGTQRLPRLVGLARAKELL 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442633773 831 LMGERLFATELLESNsFVDKICKARNVNEMALAKAKQISTSSAEMYRTLKKLNHSAVNVTKFPRLDEELKVIGEQWVTAD 910
Cdd:COG1024  158 LTGRRIDAEEALELG-LVNRVVPDDELLAAALALAARLAAGPPLALAATKRALNAALEAPLDEALELEAEAFAELFASED 236
PRK06688 PRK06688
enoyl-CoA hydratase; Provisional
 694-910 4.29e-13

enoyl-CoA hydratase; Provisional


Pssm-ID: 235852 [Multi-domain]  Cd Length: 259  Bit Score: 70.28  E-value: 4.29e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442633773 694 SKQLLEQLNDTLSSVARKGEFNTVLLTVEGPQFCQGIDcqelIQGSLEKRKDSASQLAVALKCyLRTLATFPKPLVAGIV 773
Cdd:PRK06688  30 TAAMYQALADALEAAATDPAVRVVVLTGAGRAFSAGGD----IKDFPKAPPKPPDELAPVNRF-LRAIAALPKPVVAAVN 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442633773 774 GSQINLGVMQLPFADYVVASDDCSFETNYAKLGQLPEGYALWH-----GHQRVssevhSRLFLMGERLFATELLESNsFV 848
Cdd:PRK06688 105 GPAVGVGVSLALACDLVYASESAKFSLPFAKLGLCPDAGGSALlprliGRARA-----AEMLLLGEPLSAEEALRIG-LV 178

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 442633773 849 DKICKARNVNEMALAKAKQISTSSAEMYRTLKKLNHSAVNVTKFPRLDEELKVIGEQWVTAD 910
Cdd:PRK06688 179 NRVVPAAELDAEADAQAAKLAAGPASALRYTKRAINAATLTELEEALAREAAGFGRLLRTPD 240
ECH_1 pfam00378
Enoyl-CoA hydratase/isomerase; This family contains a diverse set of enzymes including: ...
 692-904 6.96e-12

Enoyl-CoA hydratase/isomerase; This family contains a diverse set of enzymes including: enoyl-CoA hydratase, napthoate synthase, carnitate racemase, 3-hydroxybutyryl-CoA dehydratase and dodecanoyl-CoA delta-isomerase.


Pssm-ID: 395302 [Multi-domain]  Cd Length: 251  Bit Score: 66.61  E-value: 6.96e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442633773  692 TYSKQLLEQLNDTLSSVARKGEFNTVLLTVEGPQFCQGIDCQELIQGSLekRKDSASQLAVaLKCYLRtLATFPKPLVAG 771
Cdd:pfam00378  19 ALSAELITELIQALEKLRTDPSVRAVVLTGGDKAFCAGADLKEMYGEGP--AHQALYRENV-LDLWTL-LYTCPKPVIAA 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442633773  772 IVGSQINLGVMQLPFADYVVASDDCSFETNYAKLGQLPEGYALWH-----GHQRVssevhSRLFLMGERLFATELLESnS 846
Cdd:pfam00378  95 VNGYAIGGGCELALACDIIIAADNASFGLNETKLGIIPGAGGTDRlpriiGHSKA-----MEMLLLGRRISAQEALKW-G 168

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 442633773  847 FVDKICKARNVNEMALAKAKQISTSSAEMYRTLKKLNHSAVNVTKFPRLDEELKVIGE 904
Cdd:pfam00378 169 LVDKVVPEDQLLDEARELAEKLAEKSPAALAQLKKALNAKLEDALPTQLEAEARLFYS 226
 
Name Accession Description Interval E-value
crotonase-like cd06558
Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse ...
 671-868 8.15e-28

Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. Many of these play important roles in fatty acid metabolism. In addition to a conserved structural core and the formation of trimers (or dimers of trimers), a common feature in this superfamily is the stabilization of an enolate anion intermediate derived from an acyl-CoA substrate. This is accomplished by two conserved backbone NH groups in active sites that form an oxyanion hole.


Pssm-ID: 119339 [Multi-domain]  Cd Length: 195  Bit Score: 111.50  E-value: 8.15e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442633773 671 LHKVNKVAHLVIHteRGNFGHTYSKQLLEQLNDTLSSVARKGEFNTVLLTVEGPQFCQGIDCQELiqGSLEKRKDSASQL 750
Cdd:cd06558    3 VERDGGVATITLN--RPEKRNALSLEMLDELAAALDEAEADPDVRVVVLTGAGKAFCAGADLKEL--AALSDAGEEARAF 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442633773 751 AVALKCYLRTLATFPKPLVAGIVGSQINLGVMQLPFADYVVASDDCSFETNYAKLGQLPEGYALWHGHQRVSSEVHSRLF 830
Cdd:cd06558   79 IRELQELLRALLRLPKPVIAAVNGAALGGGLELALACDIRIAAEDAKFGLPEVKLGLVPGGGGTQRLPRLVGPARARELL 158

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 442633773 831 LMGERLFATELLESNsFVDKICKARNVNEMALAKAKQI 868
Cdd:cd06558  159 LTGRRISAEEALELG-LVDEVVPDEELLAAALELARRL 195
CaiD COG1024
Enoyl-CoA hydratase/carnithine racemase [Lipid transport and metabolism]; Enoyl-CoA hydratase ...
 675-910 2.96e-17

Enoyl-CoA hydratase/carnithine racemase [Lipid transport and metabolism]; Enoyl-CoA hydratase/carnithine racemase is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440647 [Multi-domain]  Cd Length: 249  Bit Score: 82.52  E-value: 2.96e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442633773 675 NKVAHLVIHT-ERGNfghTYSKQLLEQLNDTLSSVARKGEFNTVLLTVEGPQFCQGIDCQELIQGSlekrkDSASQLAVA 753
Cdd:COG1024    7 GGVATITLNRpEKLN---ALSLEMLAELAAALDEAEADPDVRVVVLTGAGKAFCAGADLKELAAAA-----DPEEARAFA 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442633773 754 LKCY--LRTLATFPKPLVAGIVGSQINLGV-MQLpFADYVVASDDCSFETNYAKLGQLPEGYALWHGHQRVSSEVHSRLF 830
Cdd:COG1024   79 RGLQrlFRALRRLPKPVIAAVNGAALGGGLeLAL-ACDLRIAAEDARFGLPEVRLGLIPGGGGTQRLPRLVGLARAKELL 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442633773 831 LMGERLFATELLESNsFVDKICKARNVNEMALAKAKQISTSSAEMYRTLKKLNHSAVNVTKFPRLDEELKVIGEQWVTAD 910
Cdd:COG1024  158 LTGRRIDAEEALELG-LVNRVVPDDELLAAALALAARLAAGPPLALAATKRALNAALEAPLDEALELEAEAFAELFASED 236
PRK06688 PRK06688
enoyl-CoA hydratase; Provisional
 694-910 4.29e-13

enoyl-CoA hydratase; Provisional


Pssm-ID: 235852 [Multi-domain]  Cd Length: 259  Bit Score: 70.28  E-value: 4.29e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442633773 694 SKQLLEQLNDTLSSVARKGEFNTVLLTVEGPQFCQGIDcqelIQGSLEKRKDSASQLAVALKCyLRTLATFPKPLVAGIV 773
Cdd:PRK06688  30 TAAMYQALADALEAAATDPAVRVVVLTGAGRAFSAGGD----IKDFPKAPPKPPDELAPVNRF-LRAIAALPKPVVAAVN 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442633773 774 GSQINLGVMQLPFADYVVASDDCSFETNYAKLGQLPEGYALWH-----GHQRVssevhSRLFLMGERLFATELLESNsFV 848
Cdd:PRK06688 105 GPAVGVGVSLALACDLVYASESAKFSLPFAKLGLCPDAGGSALlprliGRARA-----AEMLLLGEPLSAEEALRIG-LV 178

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 442633773 849 DKICKARNVNEMALAKAKQISTSSAEMYRTLKKLNHSAVNVTKFPRLDEELKVIGEQWVTAD 910
Cdd:PRK06688 179 NRVVPAAELDAEADAQAAKLAAGPASALRYTKRAINAATLTELEEALAREAAGFGRLLRTPD 240
ECH_1 pfam00378
Enoyl-CoA hydratase/isomerase; This family contains a diverse set of enzymes including: ...
 692-904 6.96e-12

Enoyl-CoA hydratase/isomerase; This family contains a diverse set of enzymes including: enoyl-CoA hydratase, napthoate synthase, carnitate racemase, 3-hydroxybutyryl-CoA dehydratase and dodecanoyl-CoA delta-isomerase.


Pssm-ID: 395302 [Multi-domain]  Cd Length: 251  Bit Score: 66.61  E-value: 6.96e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442633773  692 TYSKQLLEQLNDTLSSVARKGEFNTVLLTVEGPQFCQGIDCQELIQGSLekRKDSASQLAVaLKCYLRtLATFPKPLVAG 771
Cdd:pfam00378  19 ALSAELITELIQALEKLRTDPSVRAVVLTGGDKAFCAGADLKEMYGEGP--AHQALYRENV-LDLWTL-LYTCPKPVIAA 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442633773  772 IVGSQINLGVMQLPFADYVVASDDCSFETNYAKLGQLPEGYALWH-----GHQRVssevhSRLFLMGERLFATELLESnS 846
Cdd:pfam00378  95 VNGYAIGGGCELALACDIIIAADNASFGLNETKLGIIPGAGGTDRlpriiGHSKA-----MEMLLLGRRISAQEALKW-G 168

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 442633773  847 FVDKICKARNVNEMALAKAKQISTSSAEMYRTLKKLNHSAVNVTKFPRLDEELKVIGE 904
Cdd:pfam00378 169 LVDKVVPEDQLLDEARELAEKLAEKSPAALAQLKKALNAKLEDALPTQLEAEARLFYS 226
PRK07511 PRK07511
enoyl-CoA hydratase; Provisional
 705-872 1.66e-10

enoyl-CoA hydratase; Provisional


Pssm-ID: 181009 [Multi-domain]  Cd Length: 260  Bit Score: 62.71  E-value: 1.66e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442633773 705 LSSVARKGEFNTVLLTVEGPQFCQGIDCQELiqgsLEKRKDSASQLAV---ALKCYLRTLATFPKPLVAGIVGSQINLGv 781
Cdd:PRK07511  39 LNTAERDPSIRAVVLTGAGGFFCAGGNLNRL----LENRAKPPSVQAAsidGLHDWIRAIRAFPKPVIAAVEGAAAGAG- 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442633773 782 MQLPFA-DYVVASDDCSFETNYAKLGQLPEGYALWHGHQRVSSEVHSRLFLMGERLFAtELLESNSFVDKICKARNVNEM 860
Cdd:PRK07511 114 FSLALAcDLLVAARDAKFVMAYVKVGLTPDGGGSWFLARALPRQLATELLLEGKPISA-ERLHALGVVNRLAEPGQALAE 192

                        170
                 ....*....|..
gi 442633773 861 ALAKAKQISTSS 872
Cdd:PRK07511 193 ALALADQLAAGS 204
PRK05870 PRK05870
enoyl-CoA hydratase; Provisional
 666-843 3.70e-09

enoyl-CoA hydratase; Provisional


Pssm-ID: 180298  Cd Length: 249  Bit Score: 58.58  E-value: 3.70e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442633773 666 SELVCLHKVNKVAHLVIHT-ERGNfghTYSKQLLEQLNDTLSSVARKGEFNTVLLTVEGPQFCQGIDCQELIQGSLEKRK 744
Cdd:PRK05870   2 MDPVLLDVDDGVALITVNDpDRRN---AVTAEMSAQLRAAVAAAEADPDVHALVVTGAGKAFCAGADLTALGAAPGRPAE 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442633773 745 DS-----ASQLAVAlKCYLRTLATfpkplVAGI-VGSQINLGVMqlpfADYVVASDDCSFETNYAKLGQLPEGYALWHGH 818
Cdd:PRK05870  79 DGlrriyDGFLAVA-SCPLPTIAA-----VNGAaVGAGLNLALA----ADVRIAGPKALFDARFQKLGLHPGGGATWMLQ 148

                        170       180
                 ....*....|....*....|....*
gi 442633773 819 QRVSSEVHSRLFLMGERLFATELLE 843
Cdd:PRK05870 149 RAVGPQVARAALLFGMRFDAEAAVR 173
PRK07827 PRK07827
enoyl-CoA hydratase family protein;
694-840 2.16e-08

enoyl-CoA hydratase family protein;


Pssm-ID: 236109 [Multi-domain]  Cd Length: 260  Bit Score: 56.23  E-value: 2.16e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442633773 694 SKQLLEQLNDTLSSVARKGEFNTVLLTVEGPQFCQGIDCQElIQGSLEKRKDSASQLAVALKCYLRTLATFPKPLVAGIV 773
Cdd:PRK07827  31 SARLVAQLHDGLRAAAADPAVRAVVLTHTGGTFCAGADLSE-AGGGGGDPYDAAVARAREMTALLRAIVELPKPVIAAID 109

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 442633773 774 GsQINLGVMQLPFA-DYVVASDDCSFETNYAKLGQLPEGYALwHGHQRVSSEVHSRLFLMGERLFATE 840
Cdd:PRK07827 110 G-HVRAGGFGLVGAcDIVVAGPESTFALTEARIGVAPAIISL-TLLPRLSPRAAARYYLTGEKFGAAE 175
PRK07658 PRK07658
enoyl-CoA hydratase; Provisional
 667-910 3.96e-08

enoyl-CoA hydratase; Provisional


Pssm-ID: 181070 [Multi-domain]  Cd Length: 257  Bit Score: 55.41  E-value: 3.96e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442633773 667 ELVCLHKVNKVAHLVIHTERGNfghTYSKQLLEQLNDTLSSVARKGEFNTVLLTVEGPQFCQGIDCQELIqgSLEKRKDs 746
Cdd:PRK07658   2 KFLSVRVEDHVAVITLNHPPAN---ALSSQVLHELSELLDQVEKDDNVRVVVIHGEGRFFSAGADIKEFT--SVTEAEQ- 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442633773 747 ASQLAVALKCYLRTLATFPKPLVAGIVGSQINLGvmqLPFAdyvvASDDCSFETNYAKLGqLPE-------GYAlwhGHQ 819
Cdd:PRK07658  76 ATELAQLGQVTFERVEKFSKPVIAAIHGAALGGG---LELA----MSCHIRFATESAKLG-LPElnlglipGFA---GTQ 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442633773 820 RVSSEVHS----RLFLMGERLFATELLESnSFVDKICKARNVNEMALAKAKQISTSSAEMYRTLKKLNHSAVNVTKFPRL 895
Cdd:PRK07658 145 RLPRYVGKakalEMMLTSEPITGAEALKW-GLVNGVFPEETLLDDAKKLAKKIAGKSPATTRAVLELLQTTKSSSYYEGV 223

                        250
                 ....*....|....*
gi 442633773 896 DEELKVIGEQWVTAD 910
Cdd:PRK07658 224 KREAKIFGEVFTSED 238
PRK06190 PRK06190
enoyl-CoA hydratase; Provisional
 694-910 5.54e-07

enoyl-CoA hydratase; Provisional


Pssm-ID: 235733  Cd Length: 258  Bit Score: 51.90  E-value: 5.54e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442633773 694 SKQLLEQLNDTLSSVARKGEFNTVLLTVEGPQFCQGIDCQELIQGSLEKRKDSASQLAValkcylRTLATFPKPLVAGIV 773
Cdd:PRK06190  29 SAALRRALFAALAEADADDDVDVVVLTGADPAFCAGLDLKELGGDGSAYGAQDALPNPS------PAWPAMRKPVIGAIN 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442633773 774 GSQINlGVMQLPFA-DYVVASDDCSFETNYAKLGQLPEgyalWHGHQRVSSEV----HSRLFLMGERLFATELLESnSFV 848
Cdd:PRK06190 103 GAAVT-GGLELALAcDILIASERARFADTHARVGILPG----WGLSVRLPQKVgigrARRMSLTGDFLDAADALRA-GLV 176

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 442633773 849 DKICKARNVNEMALAKAKQISTSSAEMYRTLKKLNHSAVNVTKFPRLDEELKVIGEQWVTAD 910
Cdd:PRK06190 177 TEVVPHDELLPRARRLAASIAGNNPAAVRALKASYDDGAAAQTGDALALEAEAARAHNRSVS 238
PRK06023 PRK06023
crotonase/enoyl-CoA hydratase family protein;
716-919 8.09e-07

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 168351  Cd Length: 251  Bit Score: 51.33  E-value: 8.09e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442633773 716 TVLLTVEGpQFCQGIDCQELIQGSLekrkdSASQLAVALKCYLRTLATFPKPLVAGIVGSQINLGVMQLPFADYVVASDD 795
Cdd:PRK06023  54 HVFLGTEG-CFSAGNDMQDFLAAAM-----GGTSFGSEILDFLIALAEAEKPIVSGVDGLAIGIGTTIHLHCDLTFASPR 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442633773 796 CSFETNYAKLGQLPEGYA-----LWHGHQRVSSevhsrLFLMGERLFATELLESnSFVDKICKARNVNEMALAKAKQIST 870
Cdd:PRK06023 128 SLFRTPFVDLALVPEAGSsllapRLMGHQRAFA-----LLALGEGFSAEAAQEA-GLIWKIVDEEAVEAETLKAAEELAA 201

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 442633773 871 SSAE---MYRTLKKLNHSAVnvtkFPRLDEELKVIGEQWVTADCLANFKRYL 919
Cdd:PRK06023 202 KPPQalqIARDLMRGPREDI----LARIDEEAKHFAARLKSAEARAAFEAFM 249
PRK06210 PRK06210
enoyl-CoA hydratase; Provisional
 717-870 8.88e-07

enoyl-CoA hydratase; Provisional


Pssm-ID: 180472  Cd Length: 272  Bit Score: 51.63  E-value: 8.88e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442633773 717 VLLTVEGPQFCQGIDCQEL--IQGSLEKRKDSASQLAVALKCYLRTLATF----PKPLVAGIVGSQINLGVMQLPFADYV 790
Cdd:PRK06210  54 IVLTGAGRGFCAGADMGELqtIDPSDGRRDTDVRPFVGNRRPDYQTRYHFltalRKPVIAAINGACAGIGLTHALMCDVR 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442633773 791 VASDDCSFETNYAKLGQLPEgyalwHGHQ----RVSSEVHSRLFLMGERLFATELLESNSFVDKICKARNVNEMALAKAK 866
Cdd:PRK06210 134 FAADGAKFTTAFARRGLIAE-----HGISwilpRLVGHANALDLLLSARTFYAEEALRLGLVNRVVPPDELMERTLAYAE 208


                 ....
gi 442633773 867 QIST 870
Cdd:PRK06210 209 DLAR 212
PRK07468 PRK07468
crotonase/enoyl-CoA hydratase family protein;
694-840 2.27e-06

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 180987 [Multi-domain]  Cd Length: 262  Bit Score: 50.06  E-value: 2.27e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442633773 694 SKQLLEQLNDTLSSVARKGEFNTVLLTVEGPQFCQGIDC---QELIQGSLEKRKDSASQLAVALkcylRTLATFPKPLVA 770
Cdd:PRK07468  30 SARMIAELTTAARRLAADAAVRVVVLTGAGKSFCAGGDLgwmRAQMTADRATRIEEARRLAMML----KALNDLPKPLIG 105

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 442633773 771 GIVGSQINLGVMQLPFADYVVASDDCSFETNYAKLGQLPEG---YALwhghQRVsSEVHSRLFLMGERLFATE 840
Cdd:PRK07468 106 RIQGQAFGGGVGLISVCDVAIAVSGARFGLTETRLGLIPATispYVV----ARM-GEANARRVFMSARLFDAE 173
PRK07110 PRK07110
polyketide biosynthesis enoyl-CoA hydratase; Validated
 666-810 5.69e-06

polyketide biosynthesis enoyl-CoA hydratase; Validated


Pssm-ID: 235936  Cd Length: 249  Bit Score: 48.81  E-value: 5.69e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442633773 666 SELVCLHKVNK-VAHLVIH-TERGNfghTYSKQLLEQLNDTLSSVARKGEFNTVLLTVEGPQFCQGIDCQEL--IQGSLE 741
Cdd:PRK07110   3 MKVVELREVEEgIAQVTMQdRVNKN---AFSDELCDQLHEAFDTIAQDPRYKVVILTGYPNYFATGGTQEGLlsLQTGKG 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442633773 742 KRKDsASQLAVALKCylrtlatfPKPLVAGIVGSQINLG-VMQLpFADYVVASDDCSFETNYAKLGQLPE 810
Cdd:PRK07110  80 TFTE-ANLYSLALNC--------PIPVIAAMQGHAIGGGlVLGL-YADIVVLSRESVYTANFMKYGFTPG 139
PRK05995 PRK05995
enoyl-CoA hydratase; Provisional
 696-843 6.82e-06

enoyl-CoA hydratase; Provisional


Pssm-ID: 235664 [Multi-domain]  Cd Length: 262  Bit Score: 48.77  E-value: 6.82e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442633773 696 QLLEQLNDTLSSVARKGEFNTVLLTVEGPQFCQGIDCQ---ELIQGSLEKRKDSASQLAValkcYLRTLATFPKPLVAGI 772
Cdd:PRK05995  31 TVIAELTAAFRALDADDSVRAVVLAGAGKAFCAGADLNwmkKMAGYSDDENRADARRLAD----MLRAIYRCPKPVIARV 106

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 442633773 773 VGSQINLGVMQLPFADYVVASDDCSFETNYAKLGQLP---EGYALWHGHQRVSsevhSRLFLMGERLFATELLE 843
Cdd:PRK05995 107 HGDAYAGGMGLVAACDIAVAADHAVFCLSEVRLGLIPatiSPYVIRAMGERAA----RRYFLTAERFDAAEALR 176
PRK07938 PRK07938
enoyl-CoA hydratase family protein;
701-883 2.26e-05

enoyl-CoA hydratase family protein;


Pssm-ID: 181174  Cd Length: 249  Bit Score: 46.89  E-value: 2.26e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442633773 701 LNDTLSSVARKGEFNTVLLTVEGPQFCQGIDCQEliqgsLEKRKDSASQLAVALKCYlrtlATF------PKPLVAGIVG 774
Cdd:PRK07938  33 LADAITAAGADPDTRVVVLRAEGRGFNAGVDIKE-----LQATPGFTALIDANRGCF----AAFravyecAVPVIAAVHG 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442633773 775 SQINLGVMQLPFADYVVASDDCSF---ETNYAKLGqlpegyALWHGHQRVSSEVHSRLFLMGERLFATELLESNSfVDKI 851
Cdd:PRK07938 104 FCLGGGIGLVGNADVIVASDDATFglpEVDRGALG------AATHLQRLVPQHLMRALFFTAATITAAELHHFGS-VEEV 176

                        170       180       190
                 ....*....|....*....|....*....|...
gi 442633773 852 CKARNVNEMALAKAKQISTSSAEMYRTLKK-LN 883
Cdd:PRK07938 177 VPRDQLDEAALEVARKIAAKDTRVIRAAKEaLN 209
PRK07854 PRK07854
enoyl-CoA hydratase; Provisional
 717-843 5.19e-03

enoyl-CoA hydratase; Provisional


Pssm-ID: 236115 [Multi-domain]  Cd Length: 243  Bit Score: 39.62  E-value: 5.19e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442633773 717 VLLTVEGPQFCQGIDcqelIQGSLekrkdSASQLAVALKCYLRTLATFPKPLVAGIVGSQINLGVmQLPFA-DYVVASDD 795
Cdd:PRK07854  47 IVLTGQGTVFCAGAD----LSGDV-----YADDFPDALIEMLHAIDAAPVPVIAAINGPAIGAGL-QLAMAcDLRVVAPE 116

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 442633773 796 CSFETNYAKLgqlpeGYAL--WhGHQRVSSEV-HSR---LFLMGERLFATELLE 843
Cdd:PRK07854 117 AYFQFPVAKY-----GIALdnW-TIRRLSSLVgGGRaraMLLGAEKLTAEQALA 164
PRK07659 PRK07659
enoyl-CoA hydratase; Provisional
 667-843 5.49e-03

enoyl-CoA hydratase; Provisional


Pssm-ID: 236073 [Multi-domain]  Cd Length: 260  Bit Score: 39.63  E-value: 5.49e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442633773 667 ELVCLHKVNKVAHLVIHteRGNFGHTYSKQLLEQLNDTLSSVARKgEFNTVLLTVEGPQFCQGIDCQELIQGSLEKRKDS 746
Cdd:PRK07659   6 ESVVVKYEGRVATIMLN--RPEALNALDEPMLKELLQALKEVAES-SAHIVVLRGNGRGFSAGGDIKMMLSSNDESKFDG 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442633773 747 ASQL--AVALkcylrTLATFPKPLVAGIVGSQINLGvmqLPFA---DYVVASDDCSFETNYAKLGQLPEGYALWHGHQRV 821
Cdd:PRK07659  83 VMNTisEIVV-----TLYTMPKLTISAIHGPAAGLG---LSIAltaDYVIADISAKLAMNFIGIGLIPDGGGHFFLQKRV 154

                        170       180
                 ....*....|....*....|..
gi 442633773 822 SSEVHSRLFLMGERLFATELLE 843
Cdd:PRK07659 155 GENKAKQIIWEGKKLSATEALD 176
PRK08140 PRK08140
enoyl-CoA hydratase; Provisional
 709-838 9.39e-03

enoyl-CoA hydratase; Provisional


Pssm-ID: 236163  Cd Length: 262  Bit Score: 39.13  E-value: 9.39e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442633773 709 ARKGEFNTVLLTVEGPQFCQGIDCQELIQGSLEKRKDSASQLAVALKCYLRTLATFPKPLVAGIVGSQINLGVmQLPFA- 787
Cdd:PRK08140  43 VEDDGARALLLTGAGRGFCAGQDLADRDVTPGGAMPDLGESIETFYNPLVRRLRALPLPVIAAVNGVAAGAGA-NLALAc 121

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 442633773 788 DYVVASDDCSFETNYAKLGQLPEGYALWHGHQRVSSEVHSRLFLMGERLFA 838
Cdd:PRK08140 122 DIVLAARSASFIQAFVKIGLVPDSGGTWFLPRLVGMARALGLALLGEKLSA 172
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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