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    CCN2 cellular communication network factor 2 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 714520, updated on 17-Aug-2024

    Summary

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    Official Symbol
    CCN2provided by VGNC
    Official Full Name
    cellular communication network factor 2provided by VGNC
    Primary source
    VGNC:VGNC:70854
    See related
    Ensembl:ENSMMUG00000014150
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Also known as
    CTGF
    Orthologs
    human mouse all
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    Genomic context

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    See CCN2 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 4 NC_041757.1 (35499610..35502866, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 4 NC_027896.1 (135512757..135515963)

    Chromosome 4 - NC_041757.1Genomic Context describing neighboring genes Neighboring gene selenoprotein K pseudogene Neighboring gene volume-regulated anion channel subunit LRRC8B pseudogene Neighboring gene ectonucleotide pyrophosphatase/phosphodiesterase 1 Neighboring gene uncharacterized LOC106998148 Neighboring gene uncharacterized LOC106998147

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Increased Expression of Connective Tissue Growth Factor (CTGF) in Multiple Organs After Exposure of Non-Human Primates (NHP) to Lethal Doses of Radiation. Zhang P, et al. Health Phys, 2015 Nov. PMID 26425899, Free PMC Article
    2. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These data suggest that CTGF levels are increased in multiple organs after radiation exposure and that inflammatory cell infiltration may contribute to the elevated levels of CTGF in multiple organs.
      Title: Increased Expression of Connective Tissue Growth Factor (CTGF) in Multiple Organs After Exposure of Non-Human Primates (NHP) to Lethal Doses of Radiation.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables heparin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables integrin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    connective tissue growth factor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041757.1 Reference Mmul_10 Primary Assembly

      Range
      35499610..35502866 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015137431.2 → XP_014992917.2  connective tissue growth factor isoform X2

      UniProtKB/TrEMBL
      A0A1D5QB22, G7MQD1, H9FQD5
      Related
      ENSMMUP00000045240.2, ENSMMUT00000061232.2
      Conserved Domains (4) summary
      pfam00093
      Location:103 → 163
      VWC; von Willebrand factor type C domain
      pfam00219
      Location:29 → 82
      IGFBP; Insulin-like growth factor binding protein
      pfam19035
      Location:199 → 242
      TSP1_CCN; CCN3 Nov like TSP1 domain
      cl21545
      Location:253 → 345
      GHB_like; Glycoprotein hormone beta chain homologues

    2. XM_028847128.1 → XP_028702961.1  connective tissue growth factor isoform X1

      Conserved Domains (4) summary
      smart00209
      Location:240 → 281
      TSP1; Thrombospondin type 1 repeats
      pfam00093
      Location:141 → 201
      VWC; von Willebrand factor type C domain
      pfam00007
      Location:291 → 383
      Cys_knot; Cystine-knot domain
      pfam00219
      Location:67 → 120
      IGFBP; Insulin-like growth factor binding protein
    Nucleotide Protein
    Heading Accession and Version

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