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Conserved domains on  [gi|1622930805|ref|XP_028702961|]
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connective tissue growth factor isoform X1 [Macaca mulatta]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
TSP1_CCN pfam19035
CCN3 Nov like TSP1 domain; This entry represents a sub-type of TSP1 domains found in ...
237-280 4.62e-19

CCN3 Nov like TSP1 domain; This entry represents a sub-type of TSP1 domains found in matricellular CCN proteins that have an alternative disulphide binding pattern compared to the canonical TSP1 domains.


:

Pssm-ID: 465952  Cd Length: 44  Bit Score: 79.68  E-value: 4.62e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1622930805 237 CLVQTTEWSACSKTCGMGISTRVTNDNASCRLEKQSRLCMVRPC 280
Cdd:pfam19035   1 CEEQSTEWSPCSKTCGMGVSTRVSNDNAECKLVTETRLCQLRPC 44
Cys_knot pfam00007
Cystine-knot domain; The family comprises glycoprotein hormones and the C-terminal domain of ...
291-383 2.50e-15

Cystine-knot domain; The family comprises glycoprotein hormones and the C-terminal domain of various extracellular proteins. It is believed to be involved in disulfide-linked dimerization.


:

Pssm-ID: 394966  Cd Length: 105  Bit Score: 71.28  E-value: 2.50e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622930805 291 GKKCIRTPKiskPIKFELSGCTSVKTYRAKFC-GVCT-------DGR-------CCTPHRTTTLPVEFKCPDGEVMKKNM 355
Cdd:pfam00007   1 RKKCIPTNY---TISVEKEGCTSCKTINTTICaGYCYtrdpvykDGRravsqrvCTYRDVTYETVVLPGCPPGVDPTVTY 77
                          90       100
                  ....*....|....*....|....*...
gi 1622930805 356 MFIKTCACHyNCPGDNDIFESLYYRKMY 383
Cdd:pfam00007  78 PVALSCHCG-NCPTDNSDCTRLSLQPDS 104
IGFBP pfam00219
Insulin-like growth factor binding protein;
67-120 4.69e-09

Insulin-like growth factor binding protein;


:

Pssm-ID: 459717  Cd Length: 53  Bit Score: 51.94  E-value: 4.69e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1622930805  67 CSGPC---RCPAEqAPRCPAGVslVLDGCGCCRVCAKQLGELCTERD-PCDphKGLFC 120
Cdd:pfam00219   1 CPPPCdpeRCPPP-PPGCPAGV--VLDGCGCCKVCARQEGEPCGVYTpPCG--KGLRC 53
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
141-201 3.77e-08

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


:

Pssm-ID: 278520  Cd Length: 57  Bit Score: 49.35  E-value: 3.77e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622930805 141 CIFGGTVYRSGESFQSSCKYQCTCLDGAVGCMPlcsmdVRLPSPDCPFPRRVKLPGKCCEE 201
Cdd:pfam00093   1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDK-----IICPPLDCPNPRLEIPPGECCPV 56
 
Name Accession Description Interval E-value
TSP1_CCN pfam19035
CCN3 Nov like TSP1 domain; This entry represents a sub-type of TSP1 domains found in ...
237-280 4.62e-19

CCN3 Nov like TSP1 domain; This entry represents a sub-type of TSP1 domains found in matricellular CCN proteins that have an alternative disulphide binding pattern compared to the canonical TSP1 domains.


Pssm-ID: 465952  Cd Length: 44  Bit Score: 79.68  E-value: 4.62e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1622930805 237 CLVQTTEWSACSKTCGMGISTRVTNDNASCRLEKQSRLCMVRPC 280
Cdd:pfam19035   1 CEEQSTEWSPCSKTCGMGVSTRVSNDNAECKLVTETRLCQLRPC 44
Cys_knot pfam00007
Cystine-knot domain; The family comprises glycoprotein hormones and the C-terminal domain of ...
291-383 2.50e-15

Cystine-knot domain; The family comprises glycoprotein hormones and the C-terminal domain of various extracellular proteins. It is believed to be involved in disulfide-linked dimerization.


Pssm-ID: 394966  Cd Length: 105  Bit Score: 71.28  E-value: 2.50e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622930805 291 GKKCIRTPKiskPIKFELSGCTSVKTYRAKFC-GVCT-------DGR-------CCTPHRTTTLPVEFKCPDGEVMKKNM 355
Cdd:pfam00007   1 RKKCIPTNY---TISVEKEGCTSCKTINTTICaGYCYtrdpvykDGRravsqrvCTYRDVTYETVVLPGCPPGVDPTVTY 77
                          90       100
                  ....*....|....*....|....*...
gi 1622930805 356 MFIKTCACHyNCPGDNDIFESLYYRKMY 383
Cdd:pfam00007  78 PVALSCHCG-NCPTDNSDCTRLSLQPDS 104
CT smart00041
C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta ...
299-368 3.94e-13

C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta (TGFbeta), nerve growth factor (NGF), platelet-derived growth factor (PDGF) and gonadotropin all form 2 highly twisted antiparallel pairs of beta-strands and contain three disulphide bonds. The domain is non-globular and little is conserved among these presumed homologues except for their cysteine residues. CT domains are predicted to form homodimers.


Pssm-ID: 214482  Cd Length: 82  Bit Score: 64.35  E-value: 3.94e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622930805  299 KISKPIKFELSGCTSVkTYRAKFC-GVCTD------------GRCCTPHRTTTLPVEFKCPDGEVMKKNMMFIKTCACHY 365
Cdd:smart00041   1 KSPVRQTITYNGCTSV-TVKNAFCeGKCGSassysiqdvqhsCSCCQPHKTKTRQVRLRCPDGSTVKKTVMHIEECGCEP 79

                   ...
gi 1622930805  366 NCP 368
Cdd:smart00041  80 NCP 82
IGFBP pfam00219
Insulin-like growth factor binding protein;
67-120 4.69e-09

Insulin-like growth factor binding protein;


Pssm-ID: 459717  Cd Length: 53  Bit Score: 51.94  E-value: 4.69e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1622930805  67 CSGPC---RCPAEqAPRCPAGVslVLDGCGCCRVCAKQLGELCTERD-PCDphKGLFC 120
Cdd:pfam00219   1 CPPPCdpeRCPPP-PPGCPAGV--VLDGCGCCKVCARQEGEPCGVYTpPCG--KGLRC 53
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
141-201 3.77e-08

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 49.35  E-value: 3.77e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622930805 141 CIFGGTVYRSGESFQSSCKYQCTCLDGAVGCMPlcsmdVRLPSPDCPFPRRVKLPGKCCEE 201
Cdd:pfam00093   1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDK-----IICPPLDCPNPRLEIPPGECCPV 56
VWC smart00214
von Willebrand factor (vWF) type C domain;
141-200 7.68e-08

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 48.67  E-value: 7.68e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622930805  141 CIFGGTVYRSGESFQSSCKYQCTCLDGA-VGCMPL-CSmdvrlPSPDCPFPRRVKLPGKCCE 200
Cdd:smart00214   1 CVHNGRVYNDGETWKPDPCQICTCLDGTtVLCDPVeCP-----PPPDCPNPERVKPPGECCP 57
IB smart00121
Insulin growth factor-binding protein homologues; High affinity binding partners of ...
72-131 2.75e-07

Insulin growth factor-binding protein homologues; High affinity binding partners of insulin-like growth factors.


Pssm-ID: 197525  Cd Length: 75  Bit Score: 47.46  E-value: 2.75e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622930805   72 RCPAEQAPRCPAG--VSLVLDGCGCCRVCAKQLGELCT-ERDPCdpHKGLFCDFGSPANRKIG 131
Cdd:smart00121   5 PCDPARCPPCPPGcaELVRLDGCGCCPVCARQEGEPCGvYTPRC--APGLRCQPPPGEERPLR 65
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
240-281 2.22e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 36.03  E-value: 2.22e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1622930805  240 QTTEWSACSKTCGMGISTRV--------TNDNASCR-LEKQSRLCMVRPCE 281
Cdd:smart00209   3 EWSEWSPCSVTCGGGVQTRTrsccspppQNGGGPCTgEDVETRACNEQPCP 53
 
Name Accession Description Interval E-value
TSP1_CCN pfam19035
CCN3 Nov like TSP1 domain; This entry represents a sub-type of TSP1 domains found in ...
237-280 4.62e-19

CCN3 Nov like TSP1 domain; This entry represents a sub-type of TSP1 domains found in matricellular CCN proteins that have an alternative disulphide binding pattern compared to the canonical TSP1 domains.


Pssm-ID: 465952  Cd Length: 44  Bit Score: 79.68  E-value: 4.62e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1622930805 237 CLVQTTEWSACSKTCGMGISTRVTNDNASCRLEKQSRLCMVRPC 280
Cdd:pfam19035   1 CEEQSTEWSPCSKTCGMGVSTRVSNDNAECKLVTETRLCQLRPC 44
Cys_knot pfam00007
Cystine-knot domain; The family comprises glycoprotein hormones and the C-terminal domain of ...
291-383 2.50e-15

Cystine-knot domain; The family comprises glycoprotein hormones and the C-terminal domain of various extracellular proteins. It is believed to be involved in disulfide-linked dimerization.


Pssm-ID: 394966  Cd Length: 105  Bit Score: 71.28  E-value: 2.50e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622930805 291 GKKCIRTPKiskPIKFELSGCTSVKTYRAKFC-GVCT-------DGR-------CCTPHRTTTLPVEFKCPDGEVMKKNM 355
Cdd:pfam00007   1 RKKCIPTNY---TISVEKEGCTSCKTINTTICaGYCYtrdpvykDGRravsqrvCTYRDVTYETVVLPGCPPGVDPTVTY 77
                          90       100
                  ....*....|....*....|....*...
gi 1622930805 356 MFIKTCACHyNCPGDNDIFESLYYRKMY 383
Cdd:pfam00007  78 PVALSCHCG-NCPTDNSDCTRLSLQPDS 104
CT smart00041
C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta ...
299-368 3.94e-13

C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta (TGFbeta), nerve growth factor (NGF), platelet-derived growth factor (PDGF) and gonadotropin all form 2 highly twisted antiparallel pairs of beta-strands and contain three disulphide bonds. The domain is non-globular and little is conserved among these presumed homologues except for their cysteine residues. CT domains are predicted to form homodimers.


Pssm-ID: 214482  Cd Length: 82  Bit Score: 64.35  E-value: 3.94e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622930805  299 KISKPIKFELSGCTSVkTYRAKFC-GVCTD------------GRCCTPHRTTTLPVEFKCPDGEVMKKNMMFIKTCACHY 365
Cdd:smart00041   1 KSPVRQTITYNGCTSV-TVKNAFCeGKCGSassysiqdvqhsCSCCQPHKTKTRQVRLRCPDGSTVKKTVMHIEECGCEP 79

                   ...
gi 1622930805  366 NCP 368
Cdd:smart00041  80 NCP 82
IGFBP pfam00219
Insulin-like growth factor binding protein;
67-120 4.69e-09

Insulin-like growth factor binding protein;


Pssm-ID: 459717  Cd Length: 53  Bit Score: 51.94  E-value: 4.69e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1622930805  67 CSGPC---RCPAEqAPRCPAGVslVLDGCGCCRVCAKQLGELCTERD-PCDphKGLFC 120
Cdd:pfam00219   1 CPPPCdpeRCPPP-PPGCPAGV--VLDGCGCCKVCARQEGEPCGVYTpPCG--KGLRC 53
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
141-201 3.77e-08

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 49.35  E-value: 3.77e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622930805 141 CIFGGTVYRSGESFQSSCKYQCTCLDGAVGCMPlcsmdVRLPSPDCPFPRRVKLPGKCCEE 201
Cdd:pfam00093   1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDK-----IICPPLDCPNPRLEIPPGECCPV 56
VWC smart00214
von Willebrand factor (vWF) type C domain;
141-200 7.68e-08

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 48.67  E-value: 7.68e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622930805  141 CIFGGTVYRSGESFQSSCKYQCTCLDGA-VGCMPL-CSmdvrlPSPDCPFPRRVKLPGKCCE 200
Cdd:smart00214   1 CVHNGRVYNDGETWKPDPCQICTCLDGTtVLCDPVeCP-----PPPDCPNPERVKPPGECCP 57
IB smart00121
Insulin growth factor-binding protein homologues; High affinity binding partners of ...
72-131 2.75e-07

Insulin growth factor-binding protein homologues; High affinity binding partners of insulin-like growth factors.


Pssm-ID: 197525  Cd Length: 75  Bit Score: 47.46  E-value: 2.75e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622930805   72 RCPAEQAPRCPAG--VSLVLDGCGCCRVCAKQLGELCT-ERDPCdpHKGLFCDFGSPANRKIG 131
Cdd:smart00121   5 PCDPARCPPCPPGcaELVRLDGCGCCPVCARQEGEPCGvYTPRC--APGLRCQPPPGEERPLR 65
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
242-280 1.82e-04

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 38.80  E-value: 1.82e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1622930805 242 TEWSACSKTCGMGISTRV-------TNDNASCRLEKQSRLCMVRPC 280
Cdd:pfam19028   7 SEWSECSVTCGGGVQTRTrtvivepQNGGRPCPELLERRPCNLPPC 52
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
240-281 2.22e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 36.03  E-value: 2.22e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1622930805  240 QTTEWSACSKTCGMGISTRV--------TNDNASCR-LEKQSRLCMVRPCE 281
Cdd:smart00209   3 EWSEWSPCSVTCGGGVQTRTrsccspppQNGGGPCTgEDVETRACNEQPCP 53
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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