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    Cfhr1 complement factor H-related 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 289057, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cfhr1provided by RGD
    Official Full Name
    complement factor H-related 1provided by RGD
    Primary source
    RGD:1310510
    See related
    EnsemblRapid:ENSRNOG00000042901 AllianceGenome:RGD:1310510
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Cfhl1
    Summary
    Predicted to enable complement component C3b binding activity and identical protein binding activity. Predicted to be involved in complement activation and cytolysis by host of symbiont cells. Predicted to be part of protein-containing complex. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in acute myeloid leukemia; age related macular degeneration 1; atypical hemolytic-uremic syndrome; and multiple myeloma. Orthologous to several human genes including CFHR1 (complement factor H related 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 2152.1) See more
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    Genomic context

    See Cfhr1 in Genome Data Viewer
    Location:
    13q13
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (53946298..53961282, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (51395583..51410571, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (56862666..56877650, complement)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene complement factor H-like Neighboring gene complement factor H-related 1, pseudogene 1 Neighboring gene POU domain, class 5, transcription factor 1 pseudogene Neighboring gene complement factor H-related 4 Neighboring gene vomeronasal 2 receptor, pseudogene 111

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables complement component C3b binding  
    enables identical protein binding  
    Process Evidence Code Pubs
    involved_in biological_process  
    involved_in complement activation  
    involved_in cytolysis by host of symbiont cells  
    Component Evidence Code Pubs
    is_active_in extracellular space  
    part_of protein-containing complex  

    General protein information

    Preferred Names
    complement factor H-related protein 1
    Names
    complement component factor h-like 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001044227.2 → NP_001037692.1  complement factor H-related protein 1 precursor

      See identical proteins and their annotated locations for NP_001037692.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      F7ESI5, Q5I0M3
      Related
      ENSRNOP00000017195.6, ENSRNOT00000017195.9
      Conserved Domains (1) summary
      cd00033
      Location:154 → 208
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      53946298..53961282 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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