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Conserved domains on  [gi|112984278|ref|NP_001037692|]
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complement factor H-related protein 1 precursor [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PHA02927 super family cl33700
secreted complement-binding protein; Provisional
 77-271 8.36e-13

secreted complement-binding protein; Provisional


The actual alignment was detected with superfamily member PHA02927:

Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 66.60  E-value: 8.36e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112984278  77 CTEAGWSPVPKCL-RICFFP-SVENGHSTSSGQTHkeGDIVQIVCNQGYSL-QNNQSTITCGEEGWSI----PPKCISPn 149
Cdd:PHA02927  70 CTGTGWTLFNQCIkRRCPSPrDIDNGQLDIGGVDF--GSSITYSCNSGYQLiGESKSYCELGSTGSMVwnpeAPICESV- 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112984278 150 sagKCGPPPSIDNGDITSLSlPEYAPLSSVEYQCQNYFLLKGNKIITCRNGKWSDPPTC-LHACVIPedilekhNIVLRW 228
Cdd:PHA02927 147 ---KCQSPPSISNGRHNGYE-DFYTDGSVVTYSCNSGYSLIGNSGVLCSGGEWSDPPTCqIVKCPHP-------TISNGY 215

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 112984278 229 RENG--RIYSQSgENIEFMCKPGYrKLRGSPpfRSKCIDGHINYP 271
Cdd:PHA02927 216 LSSGfkRSYSYN-DNVDFKCKYGY-KLSGSS--SSTCSPGNTWQP 256
 
Name Accession Description Interval E-value
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 77-271 8.36e-13

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 66.60  E-value: 8.36e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112984278  77 CTEAGWSPVPKCL-RICFFP-SVENGHSTSSGQTHkeGDIVQIVCNQGYSL-QNNQSTITCGEEGWSI----PPKCISPn 149
Cdd:PHA02927  70 CTGTGWTLFNQCIkRRCPSPrDIDNGQLDIGGVDF--GSSITYSCNSGYQLiGESKSYCELGSTGSMVwnpeAPICESV- 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112984278 150 sagKCGPPPSIDNGDITSLSlPEYAPLSSVEYQCQNYFLLKGNKIITCRNGKWSDPPTC-LHACVIPedilekhNIVLRW 228
Cdd:PHA02927 147 ---KCQSPPSISNGRHNGYE-DFYTDGSVVTYSCNSGYSLIGNSGVLCSGGEWSDPPTCqIVKCPHP-------TISNGY 215

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 112984278 229 RENG--RIYSQSgENIEFMCKPGYrKLRGSPpfRSKCIDGHINYP 271
Cdd:PHA02927 216 LSSGfkRSYSYN-DNVDFKCKYGY-KLSGSS--SSTCSPGNTWQP 256
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 154-208 8.84e-10

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 53.62  E-value: 8.84e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 112984278 154 CGPPPSIDNGDITSlSLPEYAPLSSVEYQCQNYFLLKGNKIITCR-NGKWSD-PPTC 208
Cdd:cd00033    1 CPPPPVPENGTVTG-SKGSYSYGSTVTYSCNEGYTLVGSSTITCTeNGGWSPpPPTC 56
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 154-208 5.00e-08

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 48.68  E-value: 5.00e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 112984278   154 CGPPPSIDNGDITSLSlPEYAPLSSVEYQCQNYFLLKGNKIITCR-NGKWSDP-PTC 208
Cdd:smart00032   1 CPPPPDIENGTVTSSS-GTYSYGDTVTYSCDPGYTLIGSSTITCLeNGTWSPPpPTC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
154-208 2.18e-06

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 44.03  E-value: 2.18e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 112984278  154 CGPPPSIDNGDITSLSlPEYAPLSSVEYQCQNYFLLKGNKIITCR-NGKWSDP-PTC 208
Cdd:pfam00084   1 CPPPPDIPNGKVSATK-NEYNYGASVSYECDPGYRLVGSPTITCQeDGTWSPPfPEC 56
 
Name Accession Description Interval E-value
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 77-271 8.36e-13

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 66.60  E-value: 8.36e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112984278  77 CTEAGWSPVPKCL-RICFFP-SVENGHSTSSGQTHkeGDIVQIVCNQGYSL-QNNQSTITCGEEGWSI----PPKCISPn 149
Cdd:PHA02927  70 CTGTGWTLFNQCIkRRCPSPrDIDNGQLDIGGVDF--GSSITYSCNSGYQLiGESKSYCELGSTGSMVwnpeAPICESV- 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112984278 150 sagKCGPPPSIDNGDITSLSlPEYAPLSSVEYQCQNYFLLKGNKIITCRNGKWSDPPTC-LHACVIPedilekhNIVLRW 228
Cdd:PHA02927 147 ---KCQSPPSISNGRHNGYE-DFYTDGSVVTYSCNSGYSLIGNSGVLCSGGEWSDPPTCqIVKCPHP-------TISNGY 215

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 112984278 229 RENG--RIYSQSgENIEFMCKPGYrKLRGSPpfRSKCIDGHINYP 271
Cdd:PHA02927 216 LSSGfkRSYSYN-DNVDFKCKYGY-KLSGSS--SSTCSPGNTWQP 256
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 154-208 8.84e-10

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 53.62  E-value: 8.84e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 112984278 154 CGPPPSIDNGDITSlSLPEYAPLSSVEYQCQNYFLLKGNKIITCR-NGKWSD-PPTC 208
Cdd:cd00033    1 CPPPPVPENGTVTG-SKGSYSYGSTVTYSCNEGYTLVGSSTITCTeNGGWSPpPPTC 56
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 154-208 5.00e-08

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 48.68  E-value: 5.00e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 112984278   154 CGPPPSIDNGDITSLSlPEYAPLSSVEYQCQNYFLLKGNKIITCR-NGKWSDP-PTC 208
Cdd:smart00032   1 CPPPPDIENGTVTSSS-GTYSYGDTVTYSCDPGYTLIGSSTITCLeNGTWSPPpPTC 56
PHA02954 PHA02954
EEV membrane glycoprotein; Provisional
 15-169 1.09e-06

EEV membrane glycoprotein; Provisional


Pssm-ID: 165263 [Multi-domain]  Cd Length: 317  Bit Score: 48.93  E-value: 1.09e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112984278  15 TSWFSSAKGEGIHCDFPKIRHGIVYDEKKYEPFspvpgGKILYYSCEYNFASPSSSFwnpIICTEAGWSPVPKCLRICFF 94
Cdd:PHA02954 117 TSWNDTVTCPNAECQPLQLEHGSCQPVKEKYSF-----GEHITINCDVGYEVIGASY---ISCTANSWNVIPSCQQKCDI 188

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 112984278  95 PSVENGhsTSSGQTHKEGDIVQIVCNQGYSLQNNQSTiTCGEEGWS-IPPKCISPNSAGKCGPPPSIDNGDITSLS 169
Cdd:PHA02954 189 PSLSNG--LISGSTFSIGGVIHLSCKSGFTLTGSPSS-TCIDGKWNpVLPICVRSNEEFDPVDDGPDDETDLSKLS 261
Sushi pfam00084
Sushi repeat (SCR repeat);
154-208 2.18e-06

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 44.03  E-value: 2.18e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 112984278  154 CGPPPSIDNGDITSLSlPEYAPLSSVEYQCQNYFLLKGNKIITCR-NGKWSDP-PTC 208
Cdd:pfam00084   1 CPPPPDIPNGKVSATK-NEYNYGASVSYECDPGYRLVGSPTITCQeDGTWSPPfPEC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 95-146 2.81e-06

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 43.61  E-value: 2.81e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 112984278  95 PSVENGHSTSSGQTHKEGDIVQIVCNQGYSLQNNqSTITCGEEG-WS-IPPKCI 146
Cdd:cd00033    5 PVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVGS-STITCTENGgWSpPPPTCE 57
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 95-145 8.86e-06

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 42.13  E-value: 8.86e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 112984278    95 PSVENGHSTSSGQTHKEGDIVQIVCNQGYSLQNNqSTITCGEEG-WSIP-PKC 145
Cdd:smart00032   5 PDIENGTVTSSSGTYSYGDTVTYSCDPGYTLIGS-STITCLENGtWSPPpPTC 56
PHA02639 PHA02639
EEV host range protein; Provisional
 24-209 1.20e-05

EEV host range protein; Provisional


Pssm-ID: 165022 [Multi-domain]  Cd Length: 295  Bit Score: 45.81  E-value: 1.20e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112984278  24 EGIHCDFPK-IRHGIVYD-EKKYEPfspvpgGKILYYSCEYNFASPSSSFWNPII-CTEAGWS-PVPKC-LRICFFP-SV 97
Cdd:PHA02639  18 KSIYCDKPDdISNGFITElMEKYEI------GKLIEYTCNTDYALIGDRFRTCIKdKNNAIWSnKAPFCmLKECNDPpSI 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112984278  98 ENGHSTSSGQTHKEGDIVQIVCNQ----GYSLQNNQSTITCGEEGWSI-PPKCISPNSAGkcgppPSIDNGDITSL-SLP 171
Cdd:PHA02639  92 INGKIYNKREMYKVGDEIYYVCNEhkgvQYSLVGNEKITCIQDKSWKPdPPICKMINCRF-----PALQNGYINGIpSNK 166

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 112984278 172 EYAPLSSVEYQCQNYFLLKGNKIITCR-NGKW-SDPPTCL 209
Cdd:PHA02639 167 KFYYKTRVGFSCKSGFDLVGEKYSTCNiNATWfPSIPTCV 206
PHA02817 PHA02817
EEV Host range protein; Provisional
 153-250 2.01e-04

EEV Host range protein; Provisional


Pssm-ID: 165167 [Multi-domain]  Cd Length: 225  Bit Score: 41.46  E-value: 2.01e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112984278 153 KCGPPPSIDNGDITSlSLPEYAPLSSVEYQCQNY-----FLLKGNKIITC-RNGKWS-DPPTC-LHACVIPEdilEKHNI 224
Cdd:PHA02817  23 KCCYPPSIKNGYIYN-KKTEYNIGSNVTFFCGNNtrgvrYTLVGEKNIICeKDGKWNkEFPVCkIIRCRFPA---LQNGF 98

                         90       100
                 ....*....|....*....|....*.
gi 112984278 225 VLRWRENGRIYSQSgeNIEFMCKPGY 250
Cdd:PHA02817  99 VNGIPDSKKFYYES--EVSFSCKPGF 122
PHA02954 PHA02954
EEV membrane glycoprotein; Provisional
 53-211 5.15e-04

EEV membrane glycoprotein; Provisional


Pssm-ID: 165263 [Multi-domain]  Cd Length: 317  Bit Score: 40.84  E-value: 5.15e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112984278  53 GKILYYSCEYNFASPSssfWN-PIICTEAGWSPVpkclricffpSVENGHSTSSGQTHKEGDIVQIVCNQGYSLQNnQST 131
Cdd:PHA02954 103 DETKYFRCEEKNGNTS---WNdTVTCPNAECQPL----------QLEHGSCQPVKEKYSFGEHITINCDVGYEVIG-ASY 168

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112984278 132 ITCGEEGWSIPPKCispnsAGKCGPPpSIDNGDITSLSlpeYAPLSSVEYQCQNYFLLKGNKIITCRNGKWSDP-PTCLH 210
Cdd:PHA02954 169 ISCTANSWNVIPSC-----QQKCDIP-SLSNGLISGST---FSIGGVIHLSCKSGFTLTGSPSSTCIDGKWNPVlPICVR 239


                 .
gi 112984278 211 A 211
Cdd:PHA02954 240 S 240
Sushi pfam00084
Sushi repeat (SCR repeat);
95-145 2.42e-03

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 35.55  E-value: 2.42e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 112984278   95 PSVENGHSTSSGQTHKEGDIVQIVCNQGYSLQNNqSTITCGEEG-WSIP-PKC 145
Cdd:pfam00084   5 PDIPNGKVSATKNEYNYGASVSYECDPGYRLVGS-PTITCQEDGtWSPPfPEC 56
PHA02831 PHA02831
EEV host range protein; Provisional
 53-146 3.42e-03

EEV host range protein; Provisional


Pssm-ID: 165176 [Multi-domain]  Cd Length: 268  Bit Score: 38.05  E-value: 3.42e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112984278  53 GKILYYSCEYNFASPSSSFWNPII-CTEAGWSP-VPKCLRI-CFFPSVENGHSTSSGQTHKEGDIVQIVCNQGYSLQNNq 129
Cdd:PHA02831  99 GDSVTYACKVNKLEKYSIVGNETVkCINKQWVPkYPVCKLIrCKYPALQNGFLNVFEKKFYYGDIVNFKCKKGFILLGS- 177

                         90
                 ....*....|....*....
gi 112984278 130 STITCGEEGWSIP--PKCI 146
Cdd:PHA02831 178 SVSTCDINSIWYPgiPKCV 196
PHA02831 PHA02831
EEV host range protein; Provisional
 37-197 7.13e-03

EEV host range protein; Provisional


Pssm-ID: 165176 [Multi-domain]  Cd Length: 268  Bit Score: 37.28  E-value: 7.13e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112984278  37 IVYDEKKYEPfspvpgGKILYYSCEYNFaspSSSFwnpIICTEAGWSPVPKCL--RICFFP-SVENGHSTSSGQTHKEGD 113
Cdd:PHA02831  33 DSYENKVYEE------NENLEYKCNNNF---DKVF---VTCNNGSWSTKNMCIgkRNCKDPvTILNGYIKNKKDQYSFGD 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112984278 114 IVQIVCN----QGYSLQNNQsTITCGEEGWsIP--PKCispnSAGKCgPPPSIDNGDITSLSLPEYAPlSSVEYQCQNYF 187
Cdd:PHA02831 101 SVTYACKvnklEKYSIVGNE-TVKCINKQW-VPkyPVC----KLIRC-KYPALQNGFLNVFEKKFYYG-DIVNFKCKKGF 172

                        170
                 ....*....|
gi 112984278 188 LLKGNKIITC 197
Cdd:PHA02831 173 ILLGSSVSTC 182
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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