znfl1 zinc finger-like gene 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: znfl1provided by ZNC
Official Full Name: zinc finger-like gene 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-030828-6
See related: Ensembl:ENSDARG00000037914 AllianceGenome:ZFIN:ZDB-GENE-030828-6
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb17; YF-50; sb:cb17
Summary: Predicted to enable nucleic acid binding activity and zinc ion binding activity. Acts upstream of or within hindbrain development. Is expressed in several structures, including margin; mesoderm; neural tube; neuroectoderm; and notochord. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

Location:: chromosome: 3

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	3	NC_007114.7 (34653623..34655008, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	3	NC_007114.6 (34524115..34525500, complement)

Chromosome 3 - NC_007114.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

knockdown of znfl1s using morpholinos in whole embryos or dorsal forerunner cells interrupted left-right asymmetry and normal development of the heart, liver, and pancreas
Title: Zebrafish znfl1s regulate left-right asymmetry patterning through controlling the expression of fgfr1a.
Data suggest that, in developing gastrula, Znfl1 controls developmental gene expression of Hoxb1b in embryonic posterior neuroectoderm by acting upstream of Pou5f3 and Sall4; these proteins appear to be involved in neurogenesis. (Znfl1 = zinc finger-like gene 1; Hoxb1b = homeobox B1b protein; Pou5f3 = POU domain class 5 transcription factor 3; Sall4 = spalt-like transcription factor 4)
Title: Zebrafish Znfl1 proteins control the expression of hoxb1b gene in the posterior neuroectoderm by acting upstream of pou5f3 and sall4 genes.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within hindbrain development	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: zinc finger-like gene 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.