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    tp73 tumor protein p73 [ Danio rerio (zebrafish) ]

    Gene ID: 368221, updated on 9-Dec-2024

    Summary

    Official Symbol
    tp73provided by ZNC
    Official Full Name
    tumor protein p73provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030814-2
    See related
    Ensembl:ENSDARG00000017953 AllianceGenome:ZFIN:ZDB-GENE-030814-2
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    TAp73; sb:eu652; zp73theta
    Summary
    Enables DNA-binding transcription factor activity. Acts upstream of or within embryonic cranial skeleton morphogenesis and regulation of DNA-templated transcription. Predicted to be located in cytoplasm and nucleus. Predicted to be part of transcription regulator complex. Is expressed in several structures, including gonad; musculature system; nervous system; pharynx; and renal system. Human ortholog(s) of this gene implicated in several diseases, including Epstein-Barr virus infectious disease; cervical cancer; colorectal cancer; kidney cancer (multiple); and lung cancer (multiple). Orthologous to human TP73 (tumor protein p73). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See tp73 in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (48848233..48935476)
    105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (48859431..48947191)

    Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene tumor protein p63 regulated 1-like Neighboring gene WD repeat containing, antisense to TP73 Neighboring gene retention in endoplasmic reticulum sorting receptor 1 Neighboring gene AP2 associated kinase 1a

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables transcription cis-regulatory region binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    part_of transcription regulator complex IC
    Inferred by Curator
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_183340.1NP_899183.1  tumor protein p73

      See identical proteins and their annotated locations for NP_899183.1

      Status: PROVISIONAL

      Source sequence(s)
      AY233269
      UniProtKB/TrEMBL
      A0A8M3AVI5, Q801Z7
      Related
      ENSDARP00000109684.2, ENSDART00000124737.3
      Conserved Domains (4) summary
      smart00454
      Location:498556
      SAM; Sterile alpha motif
      pfam00870
      Location:120316
      P53; P53 DNA-binding domain
      pfam07710
      Location:352391
      P53_tetramer; P53 tetramerization motif
      cl15755
      Location:498557
      SAM_superfamily; SAM (Sterile alpha motif )

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007119.7 Reference GRCz11 Primary Assembly

      Range
      48848233..48935476
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005167294.4XP_005167351.1  tumor protein p73 isoform X1

      See identical proteins and their annotated locations for XP_005167351.1

      UniProtKB/TrEMBL
      A0A8M2BER5, A0A8M3AVI5, B0S576
      Related
      ENSDARP00000109674.2, ENSDART00000130673.4
      Conserved Domains (4) summary
      smart00454
      Location:498556
      SAM; Sterile alpha motif
      pfam00870
      Location:120316
      P53; P53 DNA-binding domain
      pfam07710
      Location:352391
      P53_tetramer; P53 tetramerization motif
      cl15755
      Location:498557
      SAM_superfamily; SAM (Sterile alpha motif )
    2. XM_068222888.1XP_068078989.1  tumor protein p73 isoform X2

      UniProtKB/TrEMBL
      A0A8M2BEL8, B0S577
      Related
      ENSDARP00000074096.5, ENSDART00000079644.6