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tp73 tumor protein p73 [ Danio rerio (zebrafish) ]

Gene ID: 368221, updated on 9-Dec-2024

Summary

Official Symbol
tp73provided by ZNC
Official Full Name
tumor protein p73provided by ZNC
Primary source
ZFIN:ZDB-GENE-030814-2
See related
Ensembl:ENSDARG00000017953 AllianceGenome:ZFIN:ZDB-GENE-030814-2
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
TAp73; sb:eu652; zp73theta
Summary
Enables DNA-binding transcription factor activity. Acts upstream of or within embryonic cranial skeleton morphogenesis and regulation of DNA-templated transcription. Predicted to be located in cytoplasm and nucleus. Predicted to be part of transcription regulator complex. Is expressed in several structures, including gonad; musculature system; nervous system; pharynx; and renal system. Human ortholog(s) of this gene implicated in several diseases, including Epstein-Barr virus infectious disease; cervical cancer; colorectal cancer; kidney cancer (multiple); and lung cancer (multiple). Orthologous to human TP73 (tumor protein p73). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

See tp73 in Genome Data Viewer
Location:
chromosome: 8
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (48848233..48935476)
105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (48859431..48947191)

Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene tumor protein p63 regulated 1-like Neighboring gene WD repeat containing, antisense to TP73 Neighboring gene retention in endoplasmic reticulum sorting receptor 1 Neighboring gene AP2 associated kinase 1a

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Pathways from PubChem

General gene information

Gene Ontology Provided by ZFIN

Component Evidence Code Pubs
located_in cytoplasm  
located_in nucleus  
part_of transcription regulator complex PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_183340.1NP_899183.1  tumor protein p73

    See identical proteins and their annotated locations for NP_899183.1

    Status: PROVISIONAL

    Source sequence(s)
    AY233269
    UniProtKB/TrEMBL
    A0A8M3AVI5, Q801Z7
    Related
    ENSDARP00000109684.2, ENSDART00000124737.3
    Conserved Domains (4) summary
    smart00454
    Location:498556
    SAM; Sterile alpha motif
    pfam00870
    Location:120316
    P53; P53 DNA-binding domain
    pfam07710
    Location:352391
    P53_tetramer; P53 tetramerization motif
    cl15755
    Location:498557
    SAM_superfamily; SAM (Sterile alpha motif )

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007119.7 Reference GRCz11 Primary Assembly

    Range
    48848233..48935476
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005167294.4XP_005167351.1  tumor protein p73 isoform X1

    See identical proteins and their annotated locations for XP_005167351.1

    UniProtKB/TrEMBL
    A0A8M2BER5, A0A8M3AVI5, B0S576
    Related
    ENSDARP00000109674.2, ENSDART00000130673.4
    Conserved Domains (4) summary
    smart00454
    Location:498556
    SAM; Sterile alpha motif
    pfam00870
    Location:120316
    P53; P53 DNA-binding domain
    pfam07710
    Location:352391
    P53_tetramer; P53 tetramerization motif
    cl15755
    Location:498557
    SAM_superfamily; SAM (Sterile alpha motif )
  2. XM_068222888.1XP_068078989.1  tumor protein p73 isoform X2

    UniProtKB/TrEMBL
    A0A8M2BEL8, B0S577
    Related
    ENSDARP00000074096.5, ENSDART00000079644.6
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