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    Zpbp zona pellucida binding protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 498415, updated on 9-Dec-2024

    Summary

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    Symbol
    Zpbpprovided by RGD
    Full Name
    zona pellucida binding proteinprovided by RGD
    Primary source
    RGD:1563985
    See related
    EnsemblRapid:ENSRNOG00000027801 AllianceGenome:RGD:1563985
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in acrosome assembly and binding activity of sperm to zona pellucida. Predicted to be located in cell body. Predicted to be part of zona pellucida receptor complex. Predicted to be active in acrosomal vesicle. Human ortholog(s) of this gene implicated in spermatogenic failure 66. Orthologous to human ZPBP (zona pellucida binding protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 181.9), Thymus (RPKM 23.9) and 3 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zpbp in Genome Data Viewer
    Location:
    14q21
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (90047207..90244727, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (85830971..86030778, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (91360670..91556406, complement)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L9, pseudogene 27 Neighboring gene von Willebrand factor C domain containing 2 Neighboring gene uncharacterized LOC102552528 Neighboring gene small nucleolar RNA SNORA24 Neighboring gene uncharacterized LOC120096664 Neighboring gene sperm microtubule inner protein 7 Neighboring gene phosphoglucomutase 1, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The origin and assembly of a zona pellucida binding protein, IAM38, during spermiogenesis. Yu Y, et al. Microsc Res Tech, 2009 Aug. PMID 19204925
    2. Loss of zona pellucida binding proteins in the acrosomal matrix disrupts acrosome biogenesis and sperm morphogenesis. Lin YN, et al. Mol Cell Biol, 2007 Oct. PMID 17664285, Free PMC Article
    3. The chaperonin containing TCP1 complex (CCT/TRiC) is involved in mediating sperm-oocyte interaction. Dun MD, et al. J Biol Chem, 2011 Oct 21. PMID 21880732, Free PMC Article
    4. Proteomic characterization of the human sperm nucleus. de Mateo S, et al. Proteomics, 2011 Jul. PMID 21630459
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in acrosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within acrosome assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in binding of sperm to zona pellucida IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within binding of sperm to zona pellucida ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in acrosomal vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in acrosomal vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of zona pellucida receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of zona pellucida receptor complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zona pellucida-binding protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025139.1 → NP_001020310.1  zona pellucida-binding protein 1

      See identical proteins and their annotated locations for NP_001020310.1

      Status: PROVISIONAL

      Source sequence(s)
      BC079315
      UniProtKB/TrEMBL
      F1LRM9, Q6AXU2
      Related
      ENSRNOP00000030318.6, ENSRNOT00000039182.7
      Conserved Domains (1) summary
      pfam07354
      Location:145 → 408
      Sp38; Zona-pellucida-binding protein (Sp38)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      90047207..90244727 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063273482.1 → XP_063129552.1  zona pellucida-binding protein 1 isoform X2

    2. XM_063273483.1 → XP_063129553.1  zona pellucida-binding protein 1 isoform X3

    3. XM_039092302.2 → XP_038948230.1  zona pellucida-binding protein 1 isoform X4

      Conserved Domains (1) summary
      pfam07354
      Location:178 → 306
      Sp38; Zona-pellucida-binding protein (Sp38)

    4. XM_006251505.5 → XP_006251567.1  zona pellucida-binding protein 1 isoform X5

      See identical proteins and their annotated locations for XP_006251567.1

      UniProtKB/TrEMBL
      A0A8J8XCE4, A6KJ99
      Conserved Domains (1) summary
      pfam07354
      Location:88 → 351
      Sp38; Zona-pellucida-binding protein (Sp38)

    5. XM_039092301.2 → XP_038948229.1  zona pellucida-binding protein 1 isoform X1

      Conserved Domains (1) summary
      pfam07354
      Location:235 → 363
      Sp38; Zona-pellucida-binding protein (Sp38)

    6. XM_039092305.2 → XP_038948233.1  zona pellucida-binding protein 1 isoform X8

      Conserved Domains (1) summary
      pfam07354
      Location:102 → 230
      Sp38; Zona-pellucida-binding protein (Sp38)

    7. XM_063273485.1 → XP_063129555.1  zona pellucida-binding protein 1 isoform X9

    8. XM_039092304.2 → XP_038948232.1  zona pellucida-binding protein 1 isoform X6

      Conserved Domains (1) summary
      pfam07354
      Location:108 → 236
      Sp38; Zona-pellucida-binding protein (Sp38)

    9. XM_063273484.1 → XP_063129554.1  zona pellucida-binding protein 1 isoform X7

    10. XM_039092306.2 → XP_038948234.1  zona pellucida-binding protein 1 isoform X8

      Conserved Domains (1) summary
      pfam07354
      Location:102 → 230
      Sp38; Zona-pellucida-binding protein (Sp38)
    Nucleotide Protein Strain
    Heading Accession and Version

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